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CMV colitis

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https://www.readbyqxmd.com/read/27875354/antiviral-treatment-for-colonic-cytomegalovirus-infection-in-ulcerative-colitis-patients-significantly-improved-their-surgery-free-survival
#1
Yinghong Wang, Pankaj Aggarwal, Xiuli Liu, Haiyan Lu, Lei Lian, Xianrui Wu, Shibin Guo, Nitin Aggarwal, Bret Lashner, Bo Shen
BACKGROUND: The frequency of cytomegalovirus (CMV) colitis in steroid-refractory inflammatory bowel disease has been reported to range from 15.8% to 34.0%. Infected patients are more likely to become hospitalized, have longer lengths of stay, and higher mortality rates. Current data are limited to small scale studies and showed conflicting result regarding the role of antiviral therapy. AIMS: (1) To investigate the role of antiviral treatment in ulcerative colitis (UC) patients with CMV infection...
November 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27811628/a-national-survey-of-the-prevalence-and-impact-of-cytomegalovirus-infection-among-hospitalized-patients-with-ulcerative-colitis
#2
Laurie B Grossberg, Ghideon Ezaz, Douglas Grunwald, Jonah Cohen, Kenneth R Falchuk, Joseph D Feuerstein
GOALS: To estimate the effect of cytomegalovirus (CMV) in patients with ulcerative colitis (UC), and compare these outcomes to patients with CMV without UC. BACKGROUND: The impact of CMV infection in UC is not well understood. STUDY: We analyzed records from the Nationwide Inpatient Sample (NIS) of patients with UC and CMV between 2006 and 2012. Differences in outcomes were determined between patients with UC and CMV and those with UC without CMV...
November 2, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27763950/toward-an-algorithm-for-the-diagnosis-and-management-of-cmv-in-patients-with-colitis
#3
Lauren Beswick, Bei Ye, Daniel R van Langenberg
INTRODUCTION: Concurrent cytomegalovirus (CMV) in inflammatory bowel disease-related colitis is an important yet complex clinical scenario associated with high rates of colectomy and other morbidity. This review aimed to examine the literature to produce a comprehensive diagnostic and treatment algorithm for the management of CMV in patients with colitis. METHODS: A systematic literature review was conducted via PubMed/Medline databases until August 31, 2015, using multiple keywords in English language and where original data only presented...
December 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27714898/review-of-cytomegalovirus-coinfection-in-hiv-infected-individuals-in-africa
#4
Helene Ladefoged Grønborg, Sanne Jespersen, Bo Langhoff Hønge, Søren Jensen-Fangel, Christian Wejse
BACKGROUND: Cytomegalovirus (CMV) infection among HIV-infected individuals may cause end-organ disease, which is an AIDS-defining condition. Evidence from high-income countries suggests that CMV may alter the outcome of HIV infection, other than causing end-organ diseases. We reviewed literature on HIV and CMV coinfection in Africa. METHODS: Systematic review of published studies on HIV and CMV coinfection in Africa using the PubMed database. RESULTS: High CMV seroprevalence was found throughout Africa, exceeding 90% in most populations...
October 7, 2016: Reviews in Medical Virology
https://www.readbyqxmd.com/read/27580384/fecal-microbiota-transplantation-is-safe-and-efficacious-for-recurrent-or-refractory-clostridium-difficile-infection-in-patients-with-inflammatory-bowel-disease
#5
Monika Fischer, Dina Kao, Colleen Kelly, Aishwarya Kuchipudi, Syed-Mohammed Jafri, Mark Blumenkehl, Douglas Rex, Mark Mellow, Nirmal Kaur, Harry Sokol, Gwen Cook, Matthew J Hamilton, Emmalee Phelps, Brian Sipe, Huiping Xu, Jessica R Allegretti
BACKGROUND: New treatments are needed as Clostridium difficile infection (CDI) is becoming increasingly formidable. Fecal microbiota transplantation (FMT) has a 90% success rate in the treatment of recurrent CDI. However, evidence regarding its safety, efficacy, and effect on disease activity in patients with inflammatory bowel disease (IBD) is lacking. METHODS: This cohort study used data from 8 national and international academic centers. Patients with established IBD who underwent FMT for recurrent CDI were followed for a minimum of 3 months...
October 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27569944/extended-low-dose-valganciclovir-is-effective-prophylaxis-against-cytomegalovirus-in-high-risk-kidney-transplant-recipients-with-near-complete-eradication-of-late-onset-disease
#6
S A Fayek, E Beshears, R Lieber, N Alvey, A Sauer, J Poirier, E F Hollinger, O K Olaitan, S Jensik, J Geyston, M M Brokhof, A C Hodowanec, M Hertl, D M Simon
BACKGROUND: Cytomegalovirus (CMV)-seronegative kidney transplant (KTx) recipients of organs from CMV-seropositive donors (D+/R-) are at increased risk for CMV infection. Despite valganciclovir (VGCV) prophylaxis (900 mg daily for 200 days), late-onset CMV (LO-CMV) occurs at excessive rates. VGCV-associated cost and toxicities remain problematic. METHODS: We retrospectively evaluated 50 D+/R- adult KTx recipients from August 2008 to August 2014 who received low-dose VGCV (450 mg daily) prophylaxis for an extended duration...
July 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27471608/anti-tnf-refractory-colitis-after-checkpoint-inhibitor-therapy-possible-role-of-cmv-mediated-immunopathogenesis
#7
Katharina Lankes, Gheorghe Hundorfean, Thomas Harrer, Ansgar J Pommer, Abbas Agaimy, Irena Angelovska, Azadeh Tajmir-Riahi, Jonas Göhl, Gerold Schuler, Markus F Neurath, Werner Hohenberger, Lucie Heinzerling
Immune-related adverse events (irAEs) induced by checkpoint inhibitors are well known. Since fatal outcomes have been reported early detection and adequate management are crucial. In particular, colitis is frequently observed and can result in intestinal perforation. This is the first report of an autoimmune colitis that was treated according to algorithms but became resistant due to a CMV reactivation. The 32-y-old male patient with metastatic melanoma treated within an anti-PD-1/ipilimumab combination study developed severe immune-mediated colitis (CTCAE grade 3) with up to 18 watery stools per day starting 2 weeks after treatment initiation...
June 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27462259/bilateral-cytomegalovirus-retinitis-in-a-patient-with-systemic-lupus-erythematosus
#8
Masaya Haze, Takatoshi Kobayashi, Keigo Kakurai, Hiromi Shoda, Nanae Takai, Sayako Takeda, Rei Tada, Kouichi Maruyama, Teruyo Kida, Tsunehiko Ikeda
PURPOSE: The purpose of this study was to report the case of a patient who underwent vitrectomy for bilateral rhegmatogenous retinal detachment caused by cytomegalovirus (CMV) retinitis while undergoing steroid and immunosuppressant therapy for systemic lupus erythematosus (SLE). CASE REPORT: We report on a 29-year-old female who was undergoing steroids and immunosuppressants treatment for SLE at Osaka Medical College Hospital, Takatsuki City, Japan. Examination of the patient due to prolonged and worsening diarrhea revealed positive test results for C7-HRP, and she was diagnosed with CMV colitis...
May 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/27346662/dasatinib-induced-colitis-after-allogeneic-stem-cell-transplantation-for-philadelphia-chromosome-positive-acute-lymphoblastic-leukemia
#9
Ibrahim Aldoss, Karl Gaal, Monzr M Al Malki, Haris Ali, Ryotaro Nakamura, Stephen J Forman, Vinod Pullarkat
The tyrosine kinase inhibitor dasatinib is often used after allogeneic hematopoietic cell transplantation to treat minimal residual disease in Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). Colitis, sometimes hemorrhagic, has occasionally been described with the use of dasatinib for both chronic myeloid leukemia and Ph+ ALL. The pathogenesis of dasatinib-induced colitis is unclear but may be related to effects of dasatinib on immune function. We describe a series of 5 patients who had 7 episodes of colitis during dasatinib use...
October 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27285991/cytomegalovirus-disease-in-children-with-acute-lymphoblastic-leukemia
#10
Richa Jain, Amita Trehan, Baijyantimala Mishra, Ramandeep Singh, Bhuvan Saud, Deepak Bansal
Viral infections are an underrecognized problem in children on standard chemotherapy for acute lymphoblastic leukemia (ALL). In countries with high baseline seroprevalence of cytomegalovirus (CMV) such as India, it may be an important pathogen leading to fever, end-organ damage, and cytopenia. Data regarding the incidence and manifestations of CMV disease in pediatric ALL patients are scanty. The authors prospectively assessed all children on chemotherapy for ALL with prolonged febrile neutropenia (FN) for CMV disease over a 3-year period...
May 2016: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/27243020/cytomegalovirus-colitis-cytomegalovirus-hepatitis-and-systemic-cytomegalovirus-infection-common-features-and-differences
#11
Hiroshi Nakase, Hans Herfarth
Cytomegalovirus (CMV) is a ubiquitous human herpes virus, which, after often asymptomatic primary infection, establishes a lifelong latent infection that can periodically be reactivated in both immunocompetent and immunosuppressed carriers. Whereas the diagnostic approach in case of a suspicion of CMV reactivation is well defined, the indication for antiviral therapy can often only be made in the context of an extent of organ involvement, the immune status, and comorbidities of the patient. This article reviews the epidemiology, diagnosis, and therapy of CMV reactivation with a focus on inflammatory bowel diseases and potentially different diagnostic and therapeutic approaches in Asia and the Western world...
April 2016: Inflammatory Intestinal Diseases
https://www.readbyqxmd.com/read/27234770/effects-of-granulocyte-and-monocyte-adsorptive-apheresis-in-renal-transplantation-recipients-with-concomitant-cytomegalovirus-infection
#12
T Naganuma, Y Takemoto, T Iwai, N Kuwabara, J Uchida, T Nakatani, K Kitamura, A Masuda, K Ohmori, M Matsuura, H Nakase
BACKGROUND: Granulocyte and monocyte adsorptive apheresis (GMAA) is widely used as a treatment for active ulcerative colitis (UC) in Japan. Much attention has been paid to the possibility of GMAA for the treatment and control of cytomegalovirus (CMV) reactivation in patients with refractory UC and concomitant CMV infection. In this study, the effects of the combination of GMAA and antiviral therapy were examined in renal transplant recipients with concomitant CMV infection. METHODS: Combination therapy of GMAA and antiviral drugs was performed 9 times in 7 renal transplant recipients with concomitant CMV infection...
April 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27211020/targeting-cytomegalovirus-during-ulcerative-colitis-flare-ups
#13
Hiroshi Nakase, Kei Onodera
Human cytomegalovirus (CMV) is a common cause of opportunistic infection leading to severe and fatal disease in immune-compromised individuals. In inflammatory bowel disease patients, particularly those with ulcerative colitis (UC), CMV is often reactivated because these patients are frequently treated with immunosuppressive agents. Many reports have described the relationship between CMV reactivation and UC exacerbation, however, a therapeutic strategy for CMV infection in UC patients has not been established...
May 21, 2016: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27190660/cmv-colitis-in-immunocompetent-patients-2-cases-of-a-diagnostic-challenge
#14
Maria Paparoupa, Viola Schmidt, Helgard Weckauf, Huy Ho, Frank Schuppert
CMV infections are generally thought to be opportunistic by immunosuppression. Many literature cases though indicate that CMV infections can be also observed in immunocompetent patients. We present an unusual case of an extensive concentric benign stenosis due to CMV colitis and a case of coexistence with Crohn's Disease, both observed in nonimmunosuppressed individuals. The right diagnosis was set after implementation of multiple unsuccessful treatment strategies. Our purpose is therefore to familiarize clinicians involved with the diagnosis and treatment of gastroenterological diseases with this entity...
2016: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/27175121/pulmonary-embolism-in-an-immunocompetent-patient-with-acute-cytomegalovirus-colitis
#15
Jen-Wei Chou, Ken-Sheng Cheng
Acute cytomegalovirus (CMV) infection occurs commonly in immunocompromised and immunocompetent patients, but is usually asymptomatic in the latter. Vascular events associated with acute CMV infection have been described, but are rare. Hence, such events are rarely reported in the literature. We report a case of pulmonary embolism secondary to acute CMV colitis in an immunocompetent 78-year-old man. The patient presented with fever and diarrhea. Colonic ulcers were diagnosed based on colonoscopy findings, and CMV was the proven etiology on pathological examination...
April 2016: Intestinal Research
https://www.readbyqxmd.com/read/27166009/cytomegalovirus-colitis-mimicking-rectal-carcinoma-in-an-immunocompetent-elderly-woman
#16
Elena Chidlovskii, Alban Deroux, Sylvain Bernard, Pascal Couturier
Cytomegalovirus (CMV) colitis is uncommon in immunocompetent patients, despite a high seroprevalence rate of CMV in the general population. CMV infection has been described in individuals with compromised immune systems: in AIDS, under corticosteroid and immune modulating treatment, with cancer or haematological malignancies. Its most frequent clinical presentation is a necrotising ulcerative form; pseudotumoural CMV colitis has been described as highly exceptional. We report a case of CMV colitis mimicking rectal carcinoma in an immunocompetent elderly woman...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27093690/colonic-perforation-in-a-patient-with-systemic-lupus-erythematosus-accompanied-by-cytomegalovirus-infection-a-case-report
#17
Yuichi Tachikawa, Hiroaki Nozawa, Junichiro Tanaka, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Shinsuke Kazama, Hironori Yamaguchi, Soichiro Ishihara, Eiji Sunami, Joji Kitayama, Madoka Fujisawa, Katutoshi Takahashi, Yoshiki Sakaguchi, Tetsuo Ushiku, Masashi Fukayama, Toshiaki Watanabe
INTRODUCTION: Cytomegalovirus (CMV) infection of the gastrointestinal tract is an uncommon illness, but can be observed in immunocompromised patients. Systemic lupus erythematosus (SLE) patients are generally at high risk of CMV infection. Here we report a subacute progressive case of colitis in SLE accompanied by cytomegalovirus infection. PRESENTATION OF CASE: The patient, a 79-year-old woman, was hospitalized complaining of fever, polyarthritis, and skin ulcer that had lasted seven days...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27015999/primary-colorectal-lymphoma-comprising-both-components-of-diffuse-large-b-cell-lymphoma-and-mucosa-associated-lymphoid-tissue-lymphoma-combined-with-cytomegalovirus-colitis
#18
Ryo Katsumata, Hiroshi Matsumoto, Osawa Motoyasu, Takahisa Murao, Manabu Ishii, Minoru Fujita, Hirotoshi Tokunaga, Takashi Akiyama, Hideho Wada, Takashi Sugihara, Akiko Shiotani, Ken Haruma
A 16-year-old girl presented to our hospital with diarrhea and abdominal pain. The macroscopic findings of colonoscopy revealed multiple submucosal tumors and multiple ulcers, which were localized in the sigmoid colon, and diffuse granular mucosa which extended to the total colon. The pathological diagnosis was malignant lymphoma comprising both components of diffuse large B-cell lymphoma (DLBCL) and mucosa-associated lymphoid tissue (MALT) lymphoma, because the large lymphoma cells were CD20+, CD10-, and CD5-...
April 2016: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/27014426/characteristic-endoscopic-findings-and-risk-factors-for-cytomegalovirus-associated-colitis-in-patients-with-active-ulcerative-colitis
#19
Yutaka Hirayama, Takafumi Ando, Yoshiki Hirooka, Osamu Watanabe, Ryoji Miyahara, Masanao Nakamura, Takeshi Yamamura, Hidemi Goto
AIM: To identify characteristic endoscopic findings and risk factors for cytomegalovirus (CMV)-associated colitis in patients with active ulcerative colitis (UC). METHODS: A total of 149 UC patients admitted to the Department of Gastroenterology, Nagoya University Hospital, from January 2004 to December 2013 with exacerbation of UC symptoms were enrolled in this retrospective study. All medical records, including colonoscopy results, were reviewed. CMV infection was determined by the presence of CMV antigen, CMV inclusion bodies in biopsy specimens, or positive specific immunohistochemical staining for CMV...
March 25, 2016: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27010142/steroid-refractory-inflammatory-bowel-disease-is-a-risk-factor-for-cmv-infection
#20
A C Ormeci, F Akyuz, B Baran, O M Soyer, S Gokturk, M Onel, D Onel, A Agacfidan, M Demirci, G Yegen, M Gulluoglu, C Karaca, K Demir, F Besisik, S Kaymakoglu
OBJECTIVE: Patients with inflammatory bowel disease (IBD) show increased the prevalence of cytomegalovirus (CMV) infection due to the severity of the disease and the immunosuppressive treatments they receive. The aim of this study was to determine the prevalence of CMV infection in IBD patients and identify the risk factors for CMV infection with different demographic characteristics in IBD patients. PATIENTS AND METHODS: We enrolled 85 patients diagnosed with IBD (43 with ulcerative colitis (UC) and 42 with Crohn's disease (CD)) in this prospective study...
March 2016: European Review for Medical and Pharmacological Sciences
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