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https://www.readbyqxmd.com/read/29800615/peritransplant-ruxolitinib-prevents-acute-gvhd-in-myelofibrosis-patients-undergoing-allogenic-stem-cell-transplantation
#1
Nicolaus Kröger, Sharifah Shahnaz Syed Abd Kadir, Tatjana Zabelina, Anita Badbaran, Maximilian Christopeit, Francis Ayuk, Christine Wolschke
JAK inhibition by Ruxolitinib is approved for treatment of myelofibrosis and showed efficacy in steroid resistant acute and chronic graft-versus-host disease (GVHD) In twelve patients with a median age of 63 years (range 43-71) and myelofibrosis who were treated with ruxolitinib and underwent allogeneic stem cell transplantation (ASCT) ruxolitinib was continued (2 x 5mg) daily until stable engraftment. No graft failure was observed and leukocyte engraftment was achieved after a median of 12 days (range 11 - 18) One patient developed fever of unknown origin after discontinuation of ruxolitinib, otherwise no case of withdrawal syndrome was observed...
May 22, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29765165/detection-of-cytomegalovirus-dna-in-fecal-samples-as-a-method-for-cmv-enterocolitis-diagnosis-after-allogeneic-stem-cell-transplantation
#2
Alzbeta Zavrelova, Jakub Radocha, Lenka Pliskova, Pavla Paterova, Eva Vejrazkova, Jiri Cyrany, Filip Gabalec, Miroslav Podhola, Pavel Zak
BACKGROUND: Cytomegalovirus enterocolitis is a rare but potentially life threatening complication after allogeneic stem cell transplantation. Its early diagnosis and treatment are essential for a successful outcome. OBJECTIVE: To determine the potential benefit of fecal CMV DNA detection in the diagnosis of CMV colitis among stem cell transplant recipients. STUDY DESIGN: Biopsies from the lower gastrointestinal tract, taken during 69 episodes of diarrhea, were compared with fecal samples previously examined for CMV DNA in 45 patients after allogeneic stem cell transplantation...
May 16, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29755802/cytomegalovirus-colitis-masquerading-as-apple-core-lesion-after-systemic-chemotherapy-in-a-patient-with-relapsed-acute-myeloid-leukemia
#3
Jong An, Jason Brownell, Darrell Barker, Theresa Stockinger, Robert Brady, Katherine Cebe, Russell Baur
We report the case of a 71-year-old male with relapsed acute myeloid leukemia who developed cytomegalovirus (CMV) colitis presenting as an apple-core lesion during induction chemotherapy. CMV infection occurs rarely during induction chemotherapy for acute myeloid leukemia. CMV infection is usually observed in patients with acquired immune deficiency syndrome (AIDS) and in those on immunosuppressive agents following bone marrow transplant. Although rare, CMV colitis should be considered in patients who are critically ill after systemic chemotherapy as it can cause significant morbidity and mortality...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29755533/new-onset-colitis-in-an-adult-patient-with-chronic-granulomatous-disease-treated-with-hematopoietic-stem-cell-transplantation-a-diagnostic-dilemma
#4
Kara Robertson, Stephen Couban, Desmond Leddin, Imran Ahmad, Lori Connors
Background: Chronic granulomatous disease (CGD) is a rare primary immunodeficiency characterized by recurrent life-threatening bacterial and fungal infections, granuloma formation and intestinal disease. This disease is caused by defects in NADPH oxidase, which result in the inability of phagocytes (neutrophils, monocytes and macrophages) to destroy certain microbes. The only established curative therapy for CGD is hematopoietic stem cell transplantation. Case presentation: A 23-year-old Caucasian male with X-linked chronic granulomatous disease underwent a reduced-intensity conditioning, matched unrelated donor peripheral blood stem cell transplant, after which he was started on tacrolimus and mycophenolate for graft-versus-host disease prophylaxis...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29668948/combined-infection-of-human-herpes-viruses-a-risk-factor-for-subsequent-colectomy-in-ulcerative-colitis
#5
Shuhei Hosomi, Kenji Watanabe, Yu Nishida, Hirokazu Yamagami, Tomomi Yukawa, Koji Otani, Yasuaki Nagami, Fumio Tanaka, Koichi Taira, Noriko Kamata, Tetsuya Tanigawa, Masatsugu Shiba, Toshio Watanabe, Hisashi Nagahara, Kiyoshi Maeda, Yasuhiro Fujiwara
Background: Little is known about the prevalence and pathogenicity of human herpes viruses except for cytomegalovirus (CMV) in patients with inflammatory bowel disease (IBD). The aim of this study was to determine the prevalence of human herpes viruses on colonic mucosa in patients with IBD and assess the long-term outcomes in these patients. Methods: We examined the colonic mucosal specimens from 66 patients with ulcerative colitis (UC), 54 patients with Crohn's disease (CD), and 29 healthy patients to identify the 6 most common types of human herpes virus, using multiplex polymerase chain reaction (PCR) technique...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29655972/effectiveness-and-safety-of-anti-tnf-therapy-for-inflammatory-bowel-disease-in-liver-transplant-recipients-for-primary-sclerosing-cholangitis-a-nationwide-case-series
#6
Romain Altwegg, Roman Combes, David Laharie, Victor De Ledinghen, Sylvie Radenne, Filomena Conti, Olivier Chazouilleres, Christophe Duvoux, Jérôme Dumortier, Vincent Leroy, Xavier Treton, François Durand, Sébastien Dharancy, Maria Nachury, Félix Goutorbe, Géraldine Lamblin, Lucile Boivineau, Laurent Peyrin-Biroulet, Georges-Philippe Pageaux
BACKGROUND: There is a lack of consensus regarding the treatment of inflammatory bowel disease (IBD) after liver transplantation (LT) forprimary sclerosing cholangitis (PSC). AIM: To investigate the safety and effectiveness of anti-TNF therapy in patients with IBD after a LT for PSC. METHODS: We reviewed the medical files of all of the IBD patients who underwent a LT for PSC and who were treated with anti-TNF therapy at 23 French liver transplantation centers between 1989 and 2012...
March 13, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29601437/detection-of-cytomegalovirus-in-colonic-mucosa-of-children-with-inflammatory-bowel-disease
#7
Wael El-Matary, Camelia Stefanovici, Paul Van Caeseele, Vini Deora, Jeff McCurdy
The aim of this study was to determine the frequency and management of cytomegalovirus (CMV) detection in colonic mucosa of children with inflammatory bowel disease (IBD). Children with moderate-to-severe colitis who had sigmoid biopsy specimens evaluated for CMV by hematoxylin and eosin (H&E) staining, immunohistochemistry (IHC), and polymerase chain reaction (PCR) were included. A total of 90 sigmoid biopsies were collected from 67 patient encounters from 58 patients with colitis including biopsy samples from colectomy specimens of 8 patients who had colectomy during the study period...
March 29, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29599765/herpesviruses-in-the-activated-phosphatidylinositol-3-kinase-%C3%AE-syndrome
#8
REVIEW
Jeffrey I Cohen
The phosphatidylinositol-3-kinase (PI3K)/Akt pathway is important for multiple stages of herpesvirus replication including virus entry, replication, latency, and reactivation. Recently, patients with gain-of-function mutations in the p110δ-catalytic subunit of PI3K or in the p85-regulatory subunit of PI3K have been reported. These patients have constitutively active PI3K with hyperactivation of Akt. They present with lymphoproliferation and often have infections, particularly recurrent respiratory infections and/or severe virus infections...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29594760/cmv-infection-in-pediatric-ibd
#9
REVIEW
Anat Yerushalmy-Feler, Sharona Kern-Isaacs, Shlomi Cohen
PURPOSE OF REVIEW: Patients with inflammatory bowel disease (IBD) are predisposed to infections. Cytomegalovirus (CMV) colitis in adult IBD patients, particularly ulcerative colitis (UC), is related to severe or steroid-refractory disease. The aim of this review is to summarize the data on the prevalence and role of CMV colitis in children with IBD. RECENT FINDINGS: Data on CMV colitis in children continue to be very limited due to its rarity. As in adults, children with coexisting UC and CMV tend to have more severe colitis, are resistant to corticosteroids, and are at high risk for colectomies on short- and long-term follow-up...
March 28, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29588843/protracted-severe-systemic-cytomegalovirus-disease-in-an-immunosuppressed-patient-with-ulcerative-colitis
#10
Matthew James Armstrong, Tom Thomas, Tariq Iqbal, Ralph Boulton, Jason Goh
A 33-year-old man with ulcerative colitis presented with 5-day history of fever, night sweats, abdominal pain and increased stool frequency. He was on mesalazine M/R 1 g once daily, 6-mercaptopurine (6-MP) 75 mg once daily and prednisolone 40 mg once daily. Examination revealed fever and tachycardia. Blood examinations identified a persistent leucopenia, C reactive protein of 23 mg/L and an initial alanine transaminase of 855 IU/L. Flexible sigmoidoscopy revealed well-demarcated, punched-out ulcers in the proximal rectum and distal sigmoid, with histology pathognomonic of cytomegalovirus (CMV)...
April 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29570919/de-novo-cmv-associated-collapsing-focal-segmental-glomerulosclerosis-in-a-kidney-transplant-recipient
#11
Anup M Patel, Robert D Zenenberg, Ryan J Goldberg
Collapsing focal segmental glomerulosclerosis (FSGS) is a variant of FSGS and is associated with severe nephrotic syndrome and acute kidney injury and can occur after kidney transplantation. The exact mechanism of collapsing FSGS after kidney transplantation is unknown, but potential causes include autoimmune diseases, certain malignancies, bisphosphonates, m-TOR inhibitors, interferon-alpha, HIV infection, and other viruses. We describe a case of de novo Cytomegalovirus (CMV)-associated collapsing FSGS in a kidney transplant recipient with a UL97 phosphotransferase mutation that was successfully treated with intravenous ganciclovir, intravenous immunoglobulin, and steroids...
March 23, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29532267/severe-ischemic-cytomegalovirus-proctocolitis-with-multiple-perforation
#12
Reuban Toby D'cruz, Cheryl Chien-Li Lau, Thomas Paulraj Thamboo
Cytomegalovirus (CMV) typically causes gastrointestinal infections in immunocompetent patients. Colonic perforations secondary to CMV are exceeding rare. We describe a 88-year-old male presenting with a week-long history of intractable abdominal discomfort, bloating, nausea and diarrhea. Flexible sigmoidoscopy revealed significant ulceration with yellowish slough. Emergency surgery was performed subsequently in view of multiple perforations in the rectosigmoid junction. CMV gastrointestinal infections demonstrated an ischemic process secondary to vasculitis, which accelerated the pathway to colonic perforation...
March 12, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29513050/detection-of-cytomegalovirus-by-immunohistochemistry-of-colonic-biopsies-and-quantitative-blood-polymerase-chain-reaction-evaluation-of-agreement-in-ulcerative-colitis
#13
Edyta Zagórowicz, Agnieszka Przybysz, Jakub Szlak, Agnieszka Magdziak, Paulina Wieszczy, Andrzej Mróz
OBJECTIVES: Cytomegalovirus (CMV) often reactivates in ulcerative colitis (UC). In diagnostics, along with immunohistochemistry (IHC) of colonic biopsies, blood CMV polymerase chain reaction (PCR) is gaining increasing application. We aimed to assess agreement between the density of infected colonic cells by IHC and the viral load in the blood by PCR. MATERIAL AND METHODS: We retrospectively identified patients with active UC or indeterminate colitis in whom blood CMV PCR had been performed while biopsies had been taken simultaneously...
April 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29491283/a-case-of-an-hiv-infected-patient-with-confirmed-overlapping-complications-of-severe-amebic-colitis-and-cmv-enteritis
#14
Hiromu Morikubo, Daisuke Saito, Miki Miura, Taro Sato, Shintaro Minowa, Osamu Ikezaki, Tatsuya Mitsui, Akihito Sakuraba, Mari Hayashida, Masachika Fujiwara, Kengo Tokunaga, Junji Shibahara, Hideaki Mori, Tadahiko Masaki, Shin Kawai, Tadakazu Hisamatsu
We herein report a case of simultaneous amebic colitis and cytomegalovirus (CMV) enteritis in an HIV-infected patient. The patient was a 40-year-old man who developed bloody stool and diarrhea. We diagnosed him with severe amebic colitis associated with HIV infection and administered metronidazole. While his symptoms began to improve, the patient then developed CMV enteritis. We administered ganciclovir, and his symptoms improved. However, despite control of the infection, stenosis of the descending colon caused intestinal obstruction, and colostomy was performed...
February 28, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29424814/cytomegalovirus-infection-in-pediatric-severe-ulcerative-colitis-a-multicenter-study-from-the-pediatric-inflammatory-bowel-disease-porto-group-of-the-european-society-of-pediatric-gastroenterology-hepatology-and-nutrition
#15
Shlomi Cohen, Christine Martinez-Vinson, Marina Aloi, Dan Turner, Amit Assa, Lissy de Ridder, Victorien M Wolters, Tim de Meij, Patrizia Alvisi, Jiri Bronsky, Uri Kopylov
BACKGROUND: Data on the clinical course and outcomes of pediatric patients with cytomegalovirus (CMV) infection complicating acute severe ulcerative colitis (ASC) are very limited. The aim of our study was to compare outcomes of children with ASC who were CMV positive or CMV negative. METHODS: This was a multicenter retrospective case-controlled study, from centers affiliated with the Pediatric Inflammatory Bowel Disease Porto Group of European Society of Pediatric Gastroenterology, Hepatology, and Nutrition...
March 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29407298/high-dose-valganciclovir-treatment-for-resistant-cytomegalovirus-colitis-due-to-ul97-and-ul54-mutations
#16
K M Baradhi, R L Aure, J-M El-Amm
We report the first case of a ganciclovir-resistant cytomegalovirus (CMV) involving the gastrointestinal tract that was successfully treated with high-dose valganciclovir. A kidney transplant recipient developed drug-resistant CMV colitis which was initially treated with valganciclovir, but his CMV was found to have major resistance to ganciclovir and cidofovir due to UL97 and UL54 mutations. The patient was switched to intravenous foscarnet 40 mg/kg given every twelve hours. However, foscarnet had to be discontinued after 4 days of treatment due to acute kidney injury...
January 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29403203/diagnostic-utility-of-quantitative-cytomegalovirus-dna-polymerase-chain-reaction-in-intestinal-biopsies-from-patients-with-inflammatory-bowel-disease
#17
Mousumi Paul, Ekta Gupta, Priyanka Jain, Archana Rastogi, Vikram Bhatia
OBJECTIVES: Diagnostic utility of cytomegalovirus (CMV) DNA quantitative polymerase chain reaction (qPCR) in inflammatory bowel disease (IBD) has not been established. We aimed to compare diagnostic utility of qPCR for CMV in biopsy specimens with blood, serology, and histopathology. MATERIALS AND METHODS: A total of 132 patients were included (92 ulcerative colitis [UC], 9 Crohn's disease, and 31 unclassified IBD). Comparison between CMV IgM, CMV DNA qPCR in biopsy, in blood and histopathology was done...
January 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29396069/cytomegalovirus-associated-longitudinally-extensive-transverse-myelitis-and-acute-hepatitis-in-an-immunocompetent-adult
#18
Wai Foong Hooi, Abhishek Malhotra, James Pollard
Cytomegalovirus can cause severe disease in immunocompromised patients including encephalomyelitis, hepatitis, pneumonitis, colitis and retinitis. CMV induced myelitis and hepatitis are rare in immunocompetent patients. Following a thorough search on the literature using pubmed, there were only 10 well documented CMV-induced transverse myelitis cases reported worldwide. We report a healthy young male who developed longitudinal extensive transverse myelitis and acute hepatitis secondary to CMV infection. Our case is different from the other cases as our patient had concurrent acute hepatitis and received plasma exchange therapy (PLEX) in addition to pulsed steroids and antivirals...
April 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29390512/venous-thromboembolism-related-to-cytomegalovirus-infection-a-case-report-and-literature-review
#19
REVIEW
Amar H Kelkar, Kavitha S Jacob, Eman B Yousif, John J Farrell
RATIONALE: Herein, we present a case of seemingly unprovoked portal vein thrombosis (PVT) occurring in the context of an acute cytomegalovirus (CMV) infection and prolonged debilitating fatigue. PATIENT CONCERNS: A 46-year-old male airline pilot presented with a 2 week history of abdominal pain, nausea, vomiting, watery diarrhea, and daily recurrent fevers. This was in the context of progressive, debilitating fatigue for 3 months forcing the patient to leave his job...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29340759/cecum-ulcer-is-a-reliable-endoscopic-finding-in-cytomegalovirus-colitis-concomitant-with-graft-versus-host-disease-after-allogeneic-hematopoietic-stem-cell-transplantation
#20
Kana Matsuda, Shoko Ono, Marin Ishikawa, Shuichi Miyamoto, Satoshi Abiko, Momoko Tsuda, Keiko Yamamoto, Takahiko Kudo, Yuichi Shimizu, Eiko Hayase, Daigo Hashimoto, Takanori Teshima, Yoshihiro Matsuno, Naoya Sakamoto
Although graft-versus-host disease (GVHD) is the major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT), cytomegalovirus (CMV) reactivation also occurs in patients after allo-HSCT and these conditions often clinically overlap. The aim of this study was to determine reliable endoscopic findings of CMV colitis in patients with gastrointestinal graft-versus-host-disease (GI-GVHD). Patients after allo-HSCT who were histologically confirmed to have GI-GVHD with or without CMV colitis and patients with an immunosuppressive condition were retrospectively analyzed...
May 2018: Annals of Hematology
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