Dimitri De Bundel, Assia Fafouri, Zsolt Csaba, Ellen Loyens, Sophie Lebon, Vincent El Ghouzzi, Stéphane Peineau, Guilan Vodjdani, Foteini Kiagiadaki, Najat Aourz, Jessica Coppens, Laura Walrave, Jeanelle Portelli, Patrick Vanderheyden, Siew Yeen Chai, Kyriaki Thermos, Véronique Bernard, Graham Collingridge, Stéphane Auvin, Pierre Gressens, Ilse Smolders, Pascal Dournaud
UNLABELLED: Within the hippocampus, the major somatostatin (SRIF) receptor subtype, the sst2A receptor, is localized at postsynaptic sites of the principal neurons where it modulates neuronal activity. Following agonist exposure, this receptor rapidly internalizes and recycles slowly through the trans-Golgi network. In epilepsy, a high and chronic release of somatostatin occurs, which provokes, in both rat and human tissue, a decrease in the density of this inhibitory receptor at the cell surface...
August 26, 2015: Journal of Neuroscience