keyword
MENU ▼
Read by QxMD icon Read
search

SRIF

keyword
https://www.readbyqxmd.com/read/27611866/differentiating-smoking-related-interstitial-fibrosis-srif-from-usual-interstitial-pneumonia-uip-with-emphysema-using-ct-features-based-on-pathologically-proven-cases
#1
Kum Ju Chae, Gong Yong Jin, Hyun Nyeong Jung, Keun Sang Kwon, Hyemi Choi, Yong Chul Lee, Myoung Ja Chung, Ho Sung Park
OBJECTIVE: To differentiate smoking-related interstitial fibrosis (SRIF) from usual interstitial pneumonia (UIP) with emphysema on CT in combined pulmonary fibrosis and emphysema (CPFE) patients. MATERIALS AND METHODS: This study was approved by the institutional review board and informed consent was waived. We included 65 patients who underwent lung biopsy under the suspicion of UIP pattern on HRCT, and after radiologic-pathologic correlation, they were divided into three groups: UIP without emphysema (n = 30), UIP with emphysema (n = 26), and SRIF (n = 9)...
2016: PloS One
https://www.readbyqxmd.com/read/27445472/smoking-related-interstitial-fibrosis-combined-with-pulmonary-emphysema-computed-tomography-pathologic-correlative-study-using-lobectomy-specimens
#2
Hideji Otani, Tomonori Tanaka, Kiyoshi Murata, Junya Fukuoka, Norihisa Nitta, Yukihiro Nagatani, Akinaga Sonoda, Masashi Takahashi
PURPOSE: To evaluate the incidence and pathologic correlation of thin-section computed tomography (TSCT) findings in smoking-related interstitial fibrosis (SRIF) with pulmonary emphysema. PATIENTS AND METHODS: Our study included 172 consecutive patients who underwent TSCT and subsequent lobectomy. TSCT findings including clustered cysts with visible walls (CCVW) and ground-glass attenuation with/without reticulation (GGAR) were evaluated and compared in nonsmokers and smokers and among lung locations...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27271737/peptide-aromatic-interactions-modulated-by-fluorinated-residues-synthesis-structure-and-biological-activity-of-somatostatin-analogs-containing-3-3-5-difluorophenyl-alanine
#3
Pablo Martín-Gago, Álvaro Rol, Toni Todorovski, Eric Aragón, Pau Martin-Malpartida, Xavier Verdaguer, Mariona Vallès Miret, Jimena Fernández-Carneado, Berta Ponsati, Maria J Macias, Antoni Riera
Somatostatin is a 14-residue peptide hormone that regulates the endocrine system by binding to five G-protein-coupled receptors (SSTR1-5). We have designed six new Somatostatin analogs with L-3-(3',5'-difluorophenyl)-alanine (Dfp) as a substitute of Phe and studied the effect of an electron-poor aromatic ring in the network of aromatic interactions present in Somatostatin. Replacement of each of the Phe residues (positions 6, 7 and 11) by Dfp and use of a D-Trp8 yielded peptides whose main conformations could be characterized in aqueous solution by NMR...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26969240/signalling-mechanism-for-somatostatin-receptor-5-mediated-suppression-of-ampa-responses-in-rat-retinal-ganglion-cells
#4
Qin-Qin Deng, Wen-Long Sheng, Gong Zhang, Shi-Jun Weng, Xiong-Li Yang, Yong-Mei Zhong
Somatostatin (SRIF) is involved in a variety of physiological functions via the activation of five subtypes of specific receptors (sst1-5). Here, we investigated the effects of SRIF on AMPA receptor (AMPAR)-mediated currents (AMPA currents) in isolated rat retinal ganglion cells (GCs) using patch-clamp techniques. Immunofluorescence double labelling demonstrated the expression of sst5 in rat GCs. Consistent to this, whole cell AMPA currents of GCs were dose-dependently suppressed by SRIF, and the effect was reversed by the sst5 antagonist BIM-23056...
August 2016: Neuropharmacology
https://www.readbyqxmd.com/read/26631476/parallel-inhibition-of-dopamine-amacrine-cells-and-intrinsically-photosensitive-retinal-ganglion-cells-in-a-non-image-forming-visual-circuit-of-the-mouse-retina
#5
Helen E Vuong, Claudia N Hardi, Steven Barnes, Nicholas C Brecha
An inner retinal microcircuit composed of dopamine (DA)-containing amacrine cells and melanopsin-containing, intrinsically photosensitive retinal ganglion cells (M1 ipRGCs) process information about the duration and intensity of light exposures, mediating light adaptation, circadian entrainment, pupillary reflexes, and other aspects of non-image-forming vision. The neural interaction is reciprocal: M1 ipRGCs excite DA amacrine cells, and these, in turn, feed inhibition back onto M1 ipRGCs. We found that the neuropeptide somatostatin [somatotropin release inhibiting factor (SRIF)] also inhibits the intrinsic light response of M1 ipRGCs and postulated that, to tune the bidirectional interaction of M1 ipRGCs and DA amacrine cells, SRIF amacrine cells would provide inhibitory modulation to both cell types...
December 2, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26526981/in-vitro-effects-of-somatostatin-on-the-growth-hormone-insulin-like-growth-factor-axis-in-orange-spotted-grouper-epinephelus-coioides
#6
Bin Wang, Jirong Jia, Guokun Yang, Jingkai Qin, Cong Zhang, Qiuping Zhang, Caiyun Sun, Wensheng Li
Growth in vertebrates is mainly mediated by the growth hormone (GH)-insulin-like growth factor (IGF) axis, and somatostatin (SRIF) inhibits growth by decreasing GH release at the pituitary level and antagonizing the release and action of GHRH in the hypothalamus. However, the effects of SRIF on the regulation of growth at levels other than GH release from the pituitary gland are less well known. In the present study, we comprehensively examined the pituitary and peripheral actions of SRIF on the GH-IGF axis in grouper using a primary pituitary and hepatocyte cell culture system...
October 1, 2016: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/26442444/effect-of-deletion-of-ghrelin-o-acyltransferase-on-the-pulsatile-release-of-growth-hormone-in-mice
#7
T Y Xie, S T Ngo, J D Veldhuis, P L Jeffery, L K Chopin, M Tschöp, M J Waters, V Tolle, J Epelbaum, C Chen, F J Steyn
Ghrelin, a gut hormone originating from the post-translational cleavage of preproghrelin, is the endogenous ligand of growth hormone secretagogue receptor 1a (GHS-R1a). Within the growth hormone (GH) axis, the biological activity of ghrelin requires octanoylation by ghrelin-O-acyltransferase (GOAT), conferring selective binding to the GHS-R1a receptor via acylated ghrelin. Complete loss of preproghrelin-derived signalling (through deletion of the Ghrl gene) contributes to a decline in peak GH release; however, the selective contribution of endogenous acyl-ghrelin to pulsatile GH release remains to be established...
December 2015: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/26311777/trans-modulation-of-the-somatostatin-type-2a-receptor-trafficking-by-insulin-regulated-aminopeptidase-decreases-limbic-seizures
#8
Dimitri De Bundel, Assia Fafouri, Zsolt Csaba, Ellen Loyens, Sophie Lebon, Vincent El Ghouzzi, Stéphane Peineau, Guilan Vodjdani, Foteini Kiagiadaki, Najat Aourz, Jessica Coppens, Laura Walrave, Jeanelle Portelli, Patrick Vanderheyden, Siew Yeen Chai, Kyriaki Thermos, Véronique Bernard, Graham Collingridge, Stéphane Auvin, Pierre Gressens, Ilse Smolders, Pascal Dournaud
UNLABELLED: Within the hippocampus, the major somatostatin (SRIF) receptor subtype, the sst2A receptor, is localized at postsynaptic sites of the principal neurons where it modulates neuronal activity. Following agonist exposure, this receptor rapidly internalizes and recycles slowly through the trans-Golgi network. In epilepsy, a high and chronic release of somatostatin occurs, which provokes, in both rat and human tissue, a decrease in the density of this inhibitory receptor at the cell surface...
August 26, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26243033/pegvisomant-in-combination-with-long-acting-somatostatin-analogues-in-acromegaly-the-role-of-the-gh-receptor-deletion-of-exon-3
#9
S E Franck, A J van der Lely, P J D Delhanty, J O L Jørgensen, S J C M M Neggers
BACKGROUND: Doses of the GH receptor (GHR) antagonist pegvisomant (PEGV) that normalize insulin-like growth factor 1 (IGF1) levels vary widely among acromegaly patients. Predictors for PEGV response are baseline IGF1 levels, sex, body weight and previous radiotherapy. A GHR polymorphism lacking exon 3 (d3-GHR) is frequent in the general population. The influence of d3-GHR on PEGV responsiveness in acromegaly is unclear. OBJECTIVE: To assess the influence of d3-GHR on IGF1 levels and PEGV responsiveness in acromegaly patients using combined PEGV and long-acting somatostatin receptor ligand (LA-SRIF) treatment...
November 2015: European Journal of Endocrinology
https://www.readbyqxmd.com/read/25950084/somatostatin-agonist-pasireotide-promotes-a-physiological-state-resembling-short-day-acclimation-in-the-photoperiodic-male-siberian-hamster-phodopus-sungorus
#10
R A Dumbell, F Scherbarth, V Diedrich, H A Schmid, S Steinlechner, P Barrett
The timing of growth in seasonal mammals is inextricably linked to food availability. This is exemplified in the Siberian hamster (Phodopus sungorus), which uses the annual cycle of photoperiod to optimally programme energy expenditure in anticipation of seasonal fluctuations in food resources. During the autumn, energy expenditure is progressively minimised by physiological adaptations, including a 30% reduction in body mass, comprising a reduction in both fat and lean tissues. However, the mechanistic basis of this adaptation is still unexplained...
July 2015: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/25471570/actions-of-npy-and-its-y1-and-y2-receptors-on-pulsatile-growth-hormone-secretion-during-the-fed-and-fasted-state
#11
Lili Huang, Hwee Y Tan, Matthew J Fogarty, Zane B Andrews, Johannes D Veldhuis, Herbert Herzog, Frederik J Steyn, Chen Chen
The hypothalamic NPY system plays an important role in regulating food intake and energy expenditure. Different biological actions of NPY are assigned to NPY receptor subtypes. Recent studies demonstrated a close relationship between food intake and growth hormone (GH) secretion; however, the mechanism through which endogenous NPY modulates GH release remains unknown. Moreover, conclusive evidence demonstrating a role for NPY and Y-receptors in regulating the endogenous pulsatile release of GH does not exist...
December 3, 2014: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/25437387/som230-a-new-therapeutic-modality-for-cushing-s-disease
#12
Ian Lewis, Herbert A Schmid, Rainer Kneuer, Daniel Hoyer, Antonio P Silva, Gisbert Weckbecker, Christian Bruns, Janos Pless
A rational drug design approach involving transposition of functional groups from SRIF into a reduced size cyclohexapeptide template has led to the discovery of SOM230, a novel, stable cyclohexapeptide somatostatin mimic which exhibits unique high affinity binding to human somatostatin receptors (sst1-5). This unique receptor subtype binding profile, in particular the exceptional high affinity binding to sst5, led to SOM230 being approved by EMEA and FDA in 2012 as the first effective pituitary directed therapeutic modality for Cushing's disease...
2014: Chimia
https://www.readbyqxmd.com/read/25230948/republished-smoking-related-interstitial-fibrosis-srif-pathologic-findings-and-distinction-from-other-chronic-fibrosing-lung-diseases
#13
Anna-Luise A Katzenstein
Smoking-related interstitial fibrosis (SRIF) is a common, histologically striking finding in smokers that must be distinguished from the idiopathic interstitial pneumonias and other chronic interstitial fibrosing lesions. It is characterised by marked thickening of alveolar septa by fibrosis composed of thick collagen bundles that have a distinctive hyalinised quality and often are admixed with variable numbers of hyperplastic smooth muscle fibres. There is minimal accompanying inflammation. This fibrosis is usually most prominent in subpleural and centrilobular parenchyma, but can be present elsewhere as well...
October 2014: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/25066934/usual-interstitial-pneumonia-and-smoking-related-interstitial-fibrosis-display-epithelial-to-mesenchymal-transition-in-fibroblastic-foci
#14
Alexandre Todorovic Fabro, Igor Otavio Minatel, Maristela Peres Rangel, Iris Halbwedl, Edwin Roger Parra, Vera Luiza Capelozzi, Helmut Popper
BACKGROUND: Fibroblastic foci (FF) are a major histological feature of usual interstitial pneumonia (UIP) in idiopathic pulmonary fibrosis (IPF) and collagen vascular diseases (non-IPF). In addition, FF are occasionally associated with smoking-related interstitial fibrosis (SRIF). Recent studies have suggested a role for epithelial to mesenchymal transition (EMT) in pulmonary fibrogenesis. METHODS: Here, we investigated whether EMT was present in patients with IPF (n = 19), non-IPF (n = 17), and SRIF (n = 16) using morphometric immunohistochemistry, electron microscopy, and confocal microscopy...
September 2014: Respiratory Medicine
https://www.readbyqxmd.com/read/24937542/long-term-efficacy-and-safety-of-pegvisomant-in-combination-with-long-acting-somatostatin-analogs-in-acromegaly
#15
S J C M M Neggers, S E Franck, F W M de Rooij, A H G Dallenga, R M L Poublon, R A Feelders, J A M J L Janssen, M Buchfelder, L J Hofland, J O L Jørgensen, A J van der Lely
BACKGROUND: Treatment for acromegaly patients with long-acting somatotropin release-inhibiting factor (LA-SRIF) often does not result in complete normalization of IGF-1. Addition of pegvisomant (PEGV), a GH receptor antagonist, could improve this; however, the literature has not described long-term follow-up. OBJECTIVE: To assess long-term efficacy and safety of this combined treatment in the largest current single-center cohort of patients, from 2004-2013. DESIGN: Acromegaly patients were treated for at least 6 months with a high-dose LA-SRIF...
October 2014: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/24920890/pulmonary-adenocarcinoma-mutation-profile-in-smokers-with-smoking-related-interstitial-fibrosis
#16
Andrea Primiani, Dora Dias-Santagata, A John Iafrate, Richard L Kradin
Cigarette smoking is an established cause of lung cancer. However, pulmonary fibrosis is also an independent risk factor for the development of lung cancer. Smoking-related interstitial fibrosis (SRIF) has recently been reported. We hypothesized that adenocarcinomas in lungs with SRIF might show distinct molecular changes and examined the molecular phenotype of 168 resected lung adenocarcinomas in lungs with and without SRIF. The diagnosis of SRIF was determined by histological examination, based on the presence of alveolar septal thickening, due to pauci-inflamed, hyalinized, "ropy" collagen, in areas of lung greater than 1 cm away from the tumor...
2014: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/24846611/somatostatin-receptor-mediated-suppression-of-gabaergic-synaptic-transmission-in-cultured-rat-retinal-amacrine-cells
#17
W Chen, J B Ke, H J Wu, Y Miao, F Li, X L Yang, Z Wang
Somatostatin (SRIF) modulates neurotransmitter release by activating the specific receptors (sst1-sst5). Our previous study showed that sst5 receptors are expressed in rat retinal GABAergic amacrine cells. Here, we investigated modulation of GABA release by SRIF in cultured amacrine cells, using patch-clamp techniques. The frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) in the amacrine cells was significantly reduced by SRIF, which was partially reversed by BIM 23056, an sst5 receptor antagonist, and was further rescued by addition of CYN-154806, an sst2 receptor antagonist...
July 25, 2014: Neuroscience
https://www.readbyqxmd.com/read/24780840/somatostatin-system-molecular-mechanisms-regulating-anterior-pituitary-hormones
#18
REVIEW
Tamar Eigler, Anat Ben-Shlomo
The somatostatin (SRIF) system, which includes the SRIF ligand and receptors, regulates anterior pituitary gland function, mainly inhibiting hormone secretion and to some extent pituitary tumor cell growth. SRIF-14 via its cognate G-protein-coupled receptors (subtypes 1-5) activates multiple cellular signaling pathways including adenylate cyclase/cAMP, MAPK, ion channel-dependent pathways, and others. In addition, recent data have suggested SRIF-independent constitutive SRIF receptor activity responsible for GH and ACTH inhibition in vitro...
August 2014: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/24685142/cortistatin-14-mediates-its-anticonvulsant-effects-via-sst2-and-sst3-but-not-ghrelin-receptors
#19
Najat Aourz, Jeanelle Portelli, Jessica Coppens, Dimitri De Bundel, Giuseppe Di Giovanni, Ann Van Eeckhaut, Yvette Michotte, Ilse Smolders
Cortistatin (CST)-14, a neuropeptide that is structurally and functionally related to somatostatin-14 (SRIF) binds all five somatostatin receptor subtypes (sst1-sst5). Using in vivo microdialysis and telemetry-based electroencephalographic recordings, we provide the first experimental evidence for anticonvulsive effects of CST-14 in a pilocarpine-induced seizure model in rats and mice and for the involvement of sst2 and sst3 receptors in these anticonvulsant actions of CST-14. Both receptor subtypes are required for the anticonvulsant effects of CST-14 given that co-perfusion of a selective sst2 antagonist (cyanamid15486) or a selective sst3 antagonist (SST3-ODN-8) reversed anticonvulsant effect of CST-14, and this, independently of each other...
July 2014: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/24221949/growth-hormone-secretion-during-longterm-incubation-of-the-pituitary-of-the-japanese-eel-anguilla-japonica
#20
R Suzuki, M Kishida, T Hirano
Growth hormone (GH) secretion from organ-cultured pituitaries of the eel (Anguilla japonica) was studied during incubation in a defined medium for 2 weeks, using a homologous radioimmunoassay which does not distinguish between the two molecular forms of eel GH. The total amount of GH secreted increased gradually during the incubation period; so that the amount of GH released on day 14 was about 30 times greater than that on day 1. On day 14, the proportion of GH released relative to the total amount of GH present (the sum of GH released into the medium and residual content in the pituitary) was 96% and the amount produced on day 14 was 4 times greater than the content in the unincubated pituitary...
March 1990: Fish Physiology and Biochemistry
keyword
keyword
55397
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"