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https://www.readbyqxmd.com/read/28223152/pathological-findings-and-prognosis-in-a-large-prospective-cohort-of-chronic-hypersensitivity-pneumonitis
#1
Ping Wang, Kirk D Jones, Anatoly Urisman, Brett M Elicker, Thomas Urbania, Kerri A Johannson, Deborah Assayag, Joyce Lee, Paul J Wolters, Harold R Collard, Laura L Koth
BACKGROUND: The ability of specific histopathological features to predict mortality or lung transplant in chronic hypersensitivity pneumonitis patients is unknown. METHODS: Patients with chronic hypersensitivity pneumonitis diagnosed by surgical lung biopsy were identified from an ongoing longitudinal cohort. The surgical lung biopsy slides were evaluated prospectively by an experienced thoracic pathologist using a standardized checklist to differentiate the major pathologic patterns and score the presence of specific histopathological features...
February 18, 2017: Chest
https://www.readbyqxmd.com/read/28207496/recent-advances-in-the-pathogenesis-prediction-and-management-of-rheumatoid-arthritis-associated-interstitial-lung-disease
#2
Cheilonda Johnson
PURPOSE OF REVIEW: To provide an overview of recently published articles covering interstitial lung disease associated with rheumatoid arthritis (RA-ILD). RECENT FINDINGS: Over the past year, many studies replicated previous findings in more diverse and occasionally larger populations internationally. Specifically, the association among cigarette smoking, high rheumatoid factor titer, elevated anticitrullinated protein antibody (ACPA) levels, and RA-ILD was strengthened...
February 15, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28191607/retrospective-study-of-the-clinical-characteristics-and-risk-factors-of-rheumatoid-arthritis-associated-interstitial-lung-disease
#3
Yongfeng Zhang, Hongbin Li, Nawei Wu, Xin Dong, Yi Zheng
This study aims to explore the clinical characteristics and risk factors of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD). This is a retrospective study of 550 patients with RA. All patients underwent chest high-resolution computed tomography (HRCT) scanning. (1) Two hundred thirty-seven out of five hundred fifty (43.1%) patients with RA were diagnose with ILD. 13.5% ILD occurred before RA onset, 69.6% ILD occurred within 10 years of RA onset, and 16.9% ILD occurred more than 10 years after RA onset...
February 12, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28149568/recommendations-for-the-management-of-idiopathic-pulmonary-fibrosis-in-south-africa-a-position-statement-of-the-south-african-thoracic-society
#4
REVIEW
Coenraad F N Koegelenberg, Gillian M Ainslie, Keertan Dheda, Brian W Allwood, Michelle L Wong, Umesh G Lalloo, Mohamed S Abdool-Gaffar, Hoosain Khalfey, Elvis M Irusen
Idiopathic pulmonary fibrosis (IPF) is a very specific form of a chronic, progressive fibroproliferative interstitial pneumonia of unknown aetiology. The disease is generally associated with a poor prognosis. Several international evidence-based guidelines on the diagnosis and management of IPF and other interstitial lung diseases (ILDs) have been published and updated in the last decade, and while the body of evidence for the use of some treatment modalities has grown, others have been shown to be futile and even harmful to patients...
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28120410/restrictive-allograft-syndrome-and-idiopathic-pleuroparenchymal-fibroelastosis-do-they-really-have-the-same-histology
#5
M Angeles Montero, Tina Osadolor, Reena Khiroya, M Teresa Salcedo, Jan Lukas Robertus, Alexandra Rice, Andrew G Nicholson, Antonio Roman, Victor Monforte
AIMS: Restrictive Allograft Syndrome (RAS) and idiopathic pleuroparenchymal fibroelastosis (IPPFE) are two different diseases reported to share the same histology. RAS relates to chronic allograft dysfunction in lung transplantation with IPPFE being a rare condition in native lungs. Our aim is to compare their histologies, alongside biopsies of usual interstitial pneumonia (UIP), to determine if there are differences that might help to elucidate the pathogenesis. METHODS AND RESULTS: We selected 4 post-mortem allograft lungs from patients who developed clear clinical RAS pattern, 5 biopsies diagnosed as IPPFE, 5 UIP biopsies and 5 sections of normal lung...
January 25, 2017: Histopathology
https://www.readbyqxmd.com/read/28118995/idiopathic-pulmonary-fibrosis-current-and-future-directions
#6
E Soo, H Adamali, A J Edey
Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonia and is increasingly recognised. Prior to the advent of effective therapies, achieving an early diagnosis was arguably of little prognostic consequence given IPF was considered an untreatable and uniformly fatal disease. The advent of new drug treatments has given hope for the future and raised the profile of IPF. International management guidelines highlight the critical role of radiology as part of an interstitial lung disease multidisciplinary team approach in reaching an accurate and early diagnosis of IPF...
January 21, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28073522/antisynthetase-syndrome-analysis-of-11-cases
#7
Ester Zamarrón-de Lucas, Luis Gómez Carrera, Gema Bonilla, Dessiree Petit, Alberto Mangas, Rodolfo Álvarez-Sala
INTRODUCTION: Antisynthetase syndrome (ASS) is characterised by a series of clinical manifestations such as myositis, fever, mechanic's hands and diffuse interstitial lung disease (ILD), all associated with positivity to antisynthetase antibodies. The presence of ILD will be that, to a great extent it will mark the response to treatment and prognosis. PATIENTS AND METHODS: Eleven cases of patients with ASS and pulmonary involvement in monitoring at a Pulmonary monographic consult in a third level hospital consult are described...
February 23, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/27888985/azathioprine-response-in-patients-with-fibrotic-connective-tissue-disease-associated-interstitial-lung-disease
#8
Justin M Oldham, Cathryn Lee, Eleanor Valenzi, Leah J Witt, Ayodeji Adegunsoye, Scully Hsu, Lena Chen, Steven Montner, Jonathan H Chung, Imre Noth, Rekha Vij, Mary E Strek
BACKGROUND: Azathioprine is a commonly prescribed therapy for connective tissue disease-associated interstitial lung disease (CTD-ILD). Combination therapy that included azathioprine was recently shown to increase the risk of death and hospitalization in patients with idiopathic pulmonary fibrosis. Whether azathioprine increases the risk of adverse outcomes in patients with fibrotic CTD-ILD, including those with CTD-associated usual interstitial pneumonia (UIP), remains unknown. METHODS: A retrospective cohort analysis was performed to determine the combined incidence rate of death, transplant and respiratory hospitalization associated with azathioprine exposure...
December 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27886856/a-retrospective-cohort-study-of-outcome-in-systemic-sclerosis-associated-interstitial-lung-disease
#9
Masaki Okamoto, Kiminori Fujimoto, Junko Sadohara, Kiyomi Furuya, Shinjiro Kaieda, Tomoya Miyamura, Eiichi Suematsu, Yasuhiko Kitasato, Tomotaka Kawayama, Hiroaki Ida, Masao Ichiki, Tomoaki Hoshino
BACKGROUND: The relationship between the histological pattern and survival in systemic sclerosis-associated interstitial lung disease (SSc-ILD) is unclear. In patients with SSc-ILD, we investigated whether the clinical data obtained by non-invasive examinations could be used for prognostic evaluation, and attempted to clarify whether complicating acute exacerbation (AE) and the selection of pharmacological therapy were associated with survival. METHODS: Thirty-five patients with SSc-ILD, who had not been diagnosed by surgical lung biopsy were analyzed, retrospectively...
November 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27865876/interstitial-lung-disease-in-the-elderly
#10
Karen C Patterson, Rupal J Shah, Mary K Porteous, Jason D Christie, Carly D'Errico, Matthew Chadwick, Matthew Triano, Charuhas Deshpande, Milton D Rossman, Leslie A Litzky, Maryl E Kreider, Wallace T Miller
BACKGROUND: Despite the relationship of idiopathic pulmonary fibrosis (IPF) with advancing age, little is known about the epidemiology of interstitial lung diseases (ILD) in the elderly. Here we describe the diagnoses, clinical characteristics, and outcomes of patients who were elderly at the time of ILD diagnosis. METHODS: Among subjects from a prospective cohort study of ILD, elderly was defined as age > 70. Diagnoses were derived from a multi-disciplinary review...
November 16, 2016: Chest
https://www.readbyqxmd.com/read/27829068/clinical-course-and-changes-in-high-resolution-computed-tomography-findings-in-patients-with-idiopathic-pulmonary-fibrosis-without-honeycombing
#11
Hiroyoshi Yamauchi, Masashi Bando, Tomohisa Baba, Kensuke Kataoka, Yoshihito Yamada, Hiroshi Yamamoto, Atsushi Miyamoto, Soichiro Ikushima, Takeshi Johkoh, Fumikazu Sakai, Yasuhiro Terasaki, Akira Hebisawa, Yoshinori Kawabata, Yukihiko Sugiyama, Takashi Ogura
Some patients with idiopathic pulmonary fibrosis (IPF) do not have honeycombing on high-resolution computed tomography (HRCT) at their initial evaluation. The clinical course and sequential changes in HRCT findings in these patients are not fully understood. We reviewed the cases of 43 patients with IPF without honeycombing on initial HRCT from institutions throughout Japan. All patients were diagnosed with IPF based on a surgical lung biopsy. Multidisciplinary discussions were held five times between 2011 and 2014, to exclude alternative etiologies...
2016: PloS One
https://www.readbyqxmd.com/read/27809901/combined-pulmonary-fibrosis-and-emphysema-a-retrospective-analysis-of-clinical-characteristics-treatment-and-prognosis
#12
Lijuan Zhang, Chunling Zhang, Fushi Dong, Qi Song, Fangzhou Chi, Lu Liu, Yupeng Wang, Chunli Che
BACKGROUND: Combined pulmonary fibrosis and emphysema (CPFE) is increasingly acknowledged as a separate syndrome with distinct clinical, physiological and radiological characteristics. We sought to identify physiologic and radiographic indices that predict mortality in CPFE. METHODS: Data on clinical characteristics, pulmonary function, high-resolution computed tomography (HRCT) and treatment were compared between patients with usual interstitial pneumonia (UIP) plus emphysema (CPFE group) and those with IPF alone (IPF group)...
November 3, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27801489/diagnostic-value-of-the-bronchoalveolar-lavage-in-interstitial-lung-disease
#13
Mona Mlika, Mouna Ben Kilani, Anissa Berraies, Emna Braham, Agnes Hamzaoui, Faouzi Mezni
Background The bronchoalveolar lavage (BAL) cellular analysis is an invasive method of exploration of the lung. Its diagnostic value in interstitial lung disease (ILD) is integrated to a multi-disciplianry approach implicating clinicians, radiologists and pathologists. Aim We targeted to evaluate the diagnostic value of the BAL. Methods We reported a retrospective study about patients hospitalized for an ILD since the 1st January 2011 to the 31th December 2013. Thirty three patients were admitted in the Department of Pulmonology and the BAL analyses were studied in the Department of Pathology of the same hospital...
May 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/27791236/the-ats-ers-jrs-alat-statement-ipf-by-hrct-could-predict-acute-exacerbation-of-interstitial-lung-disease-in-non-small-cell-lung-cancer
#14
Nobuhiro Asai, Eisuke Katsuda, Rie Hamanaka, Kenshi Kosaka, Ayako Matsubara, Masaki Nishimura, Hiroyuki Tanaka, Norihito Yokoe, Ayumu Takahashi, Etsuro Yamaguchi, Akihito Kubo
INTRODUCTION: Patients with non-small cell lung cancer (NSCLC) and interstitial lung disease (ILD) are at high risk of acute exacerbation of ILD (AE-ILD) when treated with systemic chemotherapy. Standard treatment for NSCLC complicated by ILD has not been established. PURPOSE AND METHODS: To examine whether the type of ILD categorized by the official ATS/ERS/JRS/ALAT statement as "idiopathic pulmonary fibrosis (IPF) by high-resolution computed tomography (HRCT)" could predict chemotherapy-induced AE-ILD in NSCLC patients with ILD, we retrospectively reviewed all patients with NSCLC complicated by ILD who had received chemotherapy at our institute from January 2007 until December 2013...
January 21, 2017: Tumori
https://www.readbyqxmd.com/read/27788297/progressive-decline-of-lung-function-in-rheumatoid-arthritis-associated-interstitial-lung-disease
#15
Jorge A Zamora-Legoff, Megan L Krause, Cynthia S Crowson, Jay H Ryu, Eric L Matteson
OBJECTIVE: Interstitial lung disease (ILD) is associated with substantial morbidity in rheumatoid arthritis (RA), but very little is known about its long-term progression. METHODS: All patients with RA-ILD seen at Mayo Clinic in 1998-2014 with at least 4 weeks follow-up and at least 1 pulmonary function test (PFT) were identified and manually screened for study inclusion. Progression was defined as a diffusing capacity for carbon monoxide (DLCO) <40% predicted or too ill to perform, or a forced vital capacity (FVC) <50% predicted...
October 27, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27758986/the-value-of-biomarkers-as-predictors-of-outcome-in-patients-with-rheumatoid-arthritis-associated-usual-interstitial-pneumonia
#16
Young Seok Lee, Ho Cheol Kim, Bo Young Lee, Chang Keun Lee, Mi-Young Kim, Se Jin Jang, Hye Sun Lee, Jieun Moon, Thomas V Colby, Dong Soon Kim
BACKGROUND: Because of the highly variable clinical course of rheumatoid arthritis-associated usual interstitial pneumonia (RA-UIP), the prediction of patient prognosis is important. OBJECTIVE: The aim of this study was to investigate the role of blood biomarkers as prognostic predictors in the patients with RA-UIP. METHODS: The blood levels of biomarkers (Krebs von den Lungen-6 [KL-6], surfactant protein-A [SP-A], matrix metalloproteinase-7 [MMP-7], interleukin-6 [IL-6], and interleukin-32 [IL-32]) were retrospectively compared with the clinical courses of 62 patients with RA-UIP...
October 7, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/27748306/current-costs-projected-financial-needs-of-india-s-universal-immunization-programme
#17
Susmita Chatterjee, Manish Pant, Pradeep Haldar, Mahesh Kumar Aggarwal, Ramanan Laxminarayan
BACKGROUND & OBJECTIVES: India's Universal Immunization Programme (UIP) is one of the largest programmes in the world in terms of quantities of vaccines administered, number of beneficiaries, number of immunization sessions, and geographical extent and diversity of areas covered. Strategic planning for the Programme requires credible information on the cost of achieving the objectives and the financial resources needed at national, State, and district levels. We present here expenditures on immunization services in India in 2012 (baseline) and projected costs for five years (2013-2017)...
June 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27729263/utility-of-transbronchial-versus-surgical-lung-biopsy-in-the-diagnosis-of-suspected-fibrotic-interstitial-lung-disease
#18
Jamie S Sheth, John A Belperio, Michael C Fishbein, Ella A Kazerooni, Amir Lagstein, Susan Murray, Jeff L Myers, Richard H Simon, Thomas H Sisson, Baskaran Sundaram, Eric S White, Meng Xia, David Zisman, Kevin R Flaherty
BACKGROUND: Surgical lung biopsy (SLB) is invasive and not possible in all patients with undiagnosed interstitial lung diseases (ILD). We hypothesized that transbronchial biopsy (TBB) findings combined with clinical and high resolution computed tomography (HRCT) data leads to a confident diagnosis congruent to SLB, and therefore avoids the need for SLB in some patients. METHODS: We evaluated 33 patients being evaluated for suspected ILD who underwent HRCT, TBB and SLB...
October 8, 2016: Chest
https://www.readbyqxmd.com/read/27719984/imaging-of-idiopathic-pulmonary-fibrosis
#19
REVIEW
Joanna E Kusmirek, Maria Daniela Martin, Jeffrey P Kanne
Idiopathic interstitial pneumonias are a heterogeneous group of diffuse lung diseases characterized by distinct clinicopathologic entities with the usual interstitial pneumonia (UIP) being the most common. The pattern of UIP can be seen in idiopathic pulmonary fibrosis (IPF) as well as in secondary causes, most commonly in connective tissue diseases. IPF is usually progressive and associated with a very poor prognosis, and newer therapies pose a risk of serious complications; therefore, diagnostic certainty is crucial...
November 2016: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/27659711/-pulmonary-manifestations-in-collagen-vascular-diseases
#20
M N A Vogel, M Kreuter, H-U Kauczor, C-P Heußel
CLINICAL/METHODICAL ISSUE: Pulmonary complications are frequent in patients with collagen vascular diseases (CVD). Frequent causes are a direct manifestation of the underlying disease, side effects of specific medications and lung infections. STANDARD RADIOLOGICAL METHODS: The standard radiological procedure for the work-up of pulmonary pathologies in patients with CVD is multidetector computed tomography (MDCT) with thin-slice high-resolution reconstruction. PERFORMANCE: The accuracy of thin-slice CT for the identification of particular disease patterns is very high...
October 2016: Der Radiologe
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