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https://www.readbyqxmd.com/read/29623671/one-and-two-stage-surgical-revision-of-peri-prosthetic-joint-infection-of-the-hip-a-pooled-individual-participant-data-analysis-of-44-cohort-studies
#1
Setor K Kunutsor, Michael R Whitehouse, Ashley W Blom, Tim Board, Peter Kay, B Mike Wroblewski, Valérie Zeller, Szu-Yuan Chen, Pang-Hsin Hsieh, Bassam A Masri, Amir Herman, Jean-Yves Jenny, Ran Schwarzkopf, John-Paul Whittaker, Ben Burston, Ronald Huang, Camilo Restrepo, Javad Parvizi, Sergio Rudelli, Emerson Honda, David E Uip, Guillem Bori, Ernesto Muñoz-Mahamud, Elizabeth Darley, Alba Ribera, Elena Cañas, Javier Cabo, José Cordero-Ampuero, Maria Luisa Sorlí Redó, Simon Strange, Erik Lenguerrand, Rachael Gooberman-Hill, Jason Webb, Alasdair MacGowan, Paul Dieppe, Matthew Wilson, Andrew D Beswick
One-stage and two-stage revision strategies are the two main options for treating established chronic peri-prosthetic joint infection (PJI) of the hip; however, there is uncertainty regarding which is the best treatment option. We aimed to compare the risk of re-infection between the two revision strategies using pooled individual participant data (IPD). Observational cohort studies with PJI of the hip treated exclusively by one- or two-stage revision and reporting re-infection outcomes were retrieved by searching MEDLINE, EMBASE, Web of Science, The Cochrane Library, and the WHO International Clinical Trials Registry Platform; as well as email contact with investigators...
April 5, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29606857/the-reliability-of-lung-ultrasound-in-assessment-of-idiopathic-pulmonary-fibrosis
#2
REVIEW
Diana Manolescu, Lavinia Davidescu, Daniel Traila, Cristian Oancea, Voicu Tudorache
Idiopathic pulmonary fibrosis (IPF) is the severest form of idiopathic interstitial pneumonia, with a median survival time estimated at 2-5 years from the time of diagnosis. It occurs mainly in elderly adults, suggesting a strong link between the fibrosis process and aging. Although chest high-resolution computed tomography (HRCT) is currently the method of choice in IPF assessment, diagnostic imaging with typical usual interstitial pneumonia (UIP) provides definitive results in only 55%, requiring an invasive surgical procedure such as lung biopsy or cryobiopsy for the final diagnostic analysis...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29590152/clinical-spectrum-and-prognostic-factors-of-possible-uip-pattern-on-high-resolution-ct-in-patients-who-underwent-surgical-lung-biopsy
#3
Yasuhiro Kondoh, Hiroyuki Taniguchi, Kensuke Kataoka, Taiki Furukawa, Ayumi Shintani, Tomoyuki Fujisawa, Takafumi Suda, Machiko Arita, Tomohisa Baba, Kazuya Ichikado, Yoshikazu Inoue, Kazuma Kishi, Tomoo Kishaba, Osamu Nishiyama, Takashi Ogura, Keisuke Tomii, Sakae Homma
BACKGROUND: Few studies have reported the diagnostic variability in patients with a possible usual interstitial pneumonia (UIP) pattern on high-resolution CT (HRCT) who underwent surgical lung biopsy (SLB), and the prognostic factors for these patients have not been fully evaluated. We retrospectively investigated the frequency of idiopathic pulmonary fibrosis (IPF) and prognostic factors in patients with possible UIP pattern on HRCT. METHODS: Consecutive patients who had a possible UIP pattern on HRCT, underwent SLB, and had a diagnosis of IIPs before SLB were retrospectively recruited from 10 hospitals...
2018: PloS One
https://www.readbyqxmd.com/read/29547052/ct-pathologic-correlation-of-major-types-of-pulmonary-fibrosis-insights-for-revisions-to-current-guidelines
#4
Jonathan H Chung, Justin M Oldham, Steven M Montner, Rekha Vij, Ayodeji Adegunsoye, Aliya N Husain, Imre Noth, David A Lynch, Mary E Strek
OBJECTIVE: The purpose of this study was to assess the diagnostic significance of CT patterns that cannot be classified according to current idiopathic pulmonary fibrosis (IPF) guidelines and of specific findings of the inconsistent with usual interstitial pneumonitis (UIP) pattern. MATERIALS AND METHODS: Subjects with a multidisciplinary diagnosis of interstitial lung disease who had undergone surgical lung biopsy and chest CT within 1 year of each other were included in the study...
March 16, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29507864/distinct-profiles-of-cd163-positive-macrophages-in-idiopathic-interstitial-pneumonias
#5
Masahiro Yamashita, Ryoko Saito, Shinji Yasuhira, Yuh Fukuda, Hironobu Sasamo, Tamotsu Sugai, Kohei Yamauchi, Makoto Maemondo
Background: The types of cells most significantly linked to individual subtypes of idiopathic interstitial pneumonias (IIPs) remain unclear. Few studies have examined CD163+ macrophages in IIPs. Objective: We retrospectively aimed to immunohistochemically characterize the CD163+ macrophages in IIPs. Methods: Paraffin-embedded lung tissue samples were obtained from 47 patients with IIPs, including idiopathic pulmonary fibrosis (IPF), idiopathic nonspecific interstitial pneumonia (NSIP), and cryptogenic organizing pneumonia (COP), and 12 normal controls were immunohistochemically analyzed, using primary antibodies against CD68 and CD163 as indicators of pan and M2 macrophages, respectively...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29468722/podoplanin-positive-myofibroblasts-a-pathologic-hallmark-of-pleuroparenchymal-fibroelastosis
#6
Yasunori Enomoto, Sayomi Matsushima, Shiori Meguro, Hideya Kawasaki, Isao Kosugi, Tomoyuki Fujisawa, Noriyuki Enomoto, Naoki Inui, Yutaro Nakamura, Takafumi Suda, Toshihide Iwashita
Pathologic differential diagnoses of pleuroparenchymal fibroelastosis (PPFE) include usual interstitial pneumonia (UIP) and pulmonary apical cap (PAC); however, there are no specific immunostaining makers to distinguish between these diseases. We performed immunohistochemistry using several pleural mesothelial cell-related markers, including cytokeratin-5/6, CAM5.2, WT-1, calretinin, desmin and podoplanin, for PPFE (n = 4), UIP (n = 10) and PAC (n = 3) lung sections. Among the examined markers, in PPFE and PAC lungs, podoplanin commonly showed positivity for spindle cells both in thickened pleura and subpleural fibroelastosis lesions; these cells were also stained with α-smooth muscle actin, a marker of myofibroblasts...
February 22, 2018: Histopathology
https://www.readbyqxmd.com/read/29464753/grade-4-asbestosis-does-not-extend-directly-from-the-respiratory-bronchiole-to-the-peripheral-lung
#7
Yoshinori Kawabata, Takahiko Kasai, Yoichiro Kobashi, Kunimitsu Kawahara, Toshimasa Uekusa, Kazuyoshi Kurashima, Yoshihiko Shimizu
AIM: To confirm whether or not grade 4 asbestosis progresses from the respiratory bronchiole to the peripheral lung. METHODS AND RESULTS: We retrospectively examined the autopsy or lobectomy specimens from 31 cases (29 males; mean age 64 years) satisfying the pathological criteria of grade 4 asbestosis. Asbestos bodies (ABs) were quantified in samples of dissolved lung and in tissue preparations on glass slides. Respiratory bronchiolar lesions were graded as 0, 1, and ≥ grade 2...
February 21, 2018: Histopathology
https://www.readbyqxmd.com/read/29446698/radiological-fibrosis-score-is-strongly-associated-with-worse-survival-in-rheumatoid-arthritis-related-interstitial-lung-disease
#8
Yuhei Ito, Machiko Arita, Shogo Kumagai, Reoto Takei, Maki Noyama, Fumiaki Tokioka, Keisuke Nishimura, Takashi Koyama, Hiromasa Tachibana, Tadashi Ishida
OBJECTIVES: High-resolution computed tomography (HRCT) parenchymal patterns have been used to predict prognosis in patients with interstitial lung disease (ILD). In idiopathic pulmonary fibrosis, the fibrosis score (i.e. the combined extent of reticulation and honeycombing) has been associated with worse survival. This study aimed to identify HRCT patterns and patient characteristics that can predict poor prognosis in rheumatoid arthritis-related ILD (RA-ILD). METHODS: We retrospectively analysed 65 patients with newly diagnosed RA-ILD from 2007 to 2016 at Kurashiki Central hospital...
March 13, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29438171/analysis-of-the-histologic-features-associated-with-interobserver-variation-in-idiopathic-pulmonary-fibrosis
#9
Kati Mäkelä, Ulla Hodgson, Anneli Piilonen, Katariina Kelloniemi, Risto Bloigu, Eva Sutinen, Kaisa Salmenkivi, Mikko Rönty, Elisa Lappi-Blanco, Marjukka Myllärniemi, Riitta Kaarteenaho
The histologic manifestation of idiopathic pulmonary fibrosis (IPF) is usual interstitial pneumonia (UIP), which is a good prognostic determinant of survival compared with other histologic interstitial lung disease patterns. According to the current international guidelines, the histologic features of suspected IPF/UIP are divided into 4 categories: UIP, probable UIP, possible UIP, and not UIP pattern. Four pulmonary pathologists who were blinded to clinicoradiologic information reevaluated 50 surgical lung biopsies (83...
May 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29435735/immunosuppressive-tumor-microenvironment-of-usual-interstitial-pneumonia-associated-squamous-cell-carcinoma-of-the-lung
#10
Takuya Ueda, Keiju Aokage, Hiroyoshi Nishikawa, Shinya Neri, Hiroshi Nakamura, Masato Sugano, Kenta Tane, Tomohiro Miyoshi, Motohiro Kojima, Satoshi Fujii, Takeshi Kuwata, Atsushi Ochiai, Masahiko Kusumoto, Kenji Suzuki, Masahiro Tsuboi, Genichiro Ishii
PURPOSE: Patients with usual interstitial pneumonia (UIP) often develop lung cancer. However, the biological features of lung cancer associated with UIP remain unknown. The aim of this study was to elucidate the clinicopathological characteristics of UIP-associated squamous cell carcinoma (SqCC). METHODS: A total of 244 patients with p-stage I lung SqCC who underwent complete surgical resection were enrolled in this study. Clinicopathological differences between UIP-associated SqCC and non-UIP SqCC were examined...
February 12, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29422289/prevalence-and-effects-of-emphysema-in-never-smokers-with-rheumatoid-arthritis-interstitial-lung-disease
#11
Joseph Jacob, Jin Woo Song, Hee-Young Yoon, Gary Cross, Joseph Barnett, Wen Ling Woo, Fern Adams, Maria Kokosi, Anand Devaraj, Elisabetta Renzoni, Toby M Maher, Dong Soon Kim, Athol U Wells
AIMS: Autoimmune conditions such as rheumatoid arthritis-related interstitial lung disease (RA-ILD) have been linked to the existence of emphysema in never-smokers. We aimed to quantify emphysema prevalence in RA-ILD never-smokers and investigate whether combined pulmonary fibrosis and emphysema (CPFE) results in a worsened prognosis independent of baseline disease extent. METHODS: RA-ILD patients presenting to the Royal Brompton Hospital (n=90) and Asan Medical Center (n=155) had CT's evaluated for a definite usual interstitial pneumonia (UIP) pattern, and visual extents of emphysema and ILD...
January 31, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29422061/n-acetylcysteine-exposure-is-associated-with-improved-survival-in-anti-nuclear-antibody-seropositive-patients-with-usual-interstitial-pneumonia
#12
Justin M Oldham, Leah J Witt, Ayodeji Adegunsoye, Jonathan H Chung, Cathryn Lee, Scully Hsu, Lena W Chen, Aliya Husain, Steven Montner, Rekha Vij, Mary E Strek, Imre Noth
BACKGROUND: Mortality is similarly high among individuals with usual interstitial pneumonia (UIP) due to idiopathic pulmonary fibrosis (IPF) and interstitial pneumonia with autoimmune features (IPAF). Circulating anti-nuclear antibodies (ANA) are commonly found in this patient population, suggesting possible aberrant immune activation. Because an environment of oxidative stress can result from immunologic activation, we hypothesized that ANA positive patients with UIP would have improved outcome when exposed to the antioxidant N-acetylcysteine (NAC) compared to ANA negative patients...
February 8, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29413504/several-high-resolution-computed-tomography-findings-associate-with-survival-and-clinical-features-in-rheumatoid-arthritis-associated-interstitial-lung-disease
#13
Hanna M Nurmi, Hannu-Pekka Kettunen, Sanna-Katja Suoranta, Minna K Purokivi, Miia S Kärkkäinen, Tuomas A Selander, Riitta L Kaarteenaho
OBJECTIVE: To compare the presence and extent of several high-resolution computed tomography (HRCT) observations in different subtypes of rheumatoid arthritis-related interstitial lung disease (RA-ILD) and to examine associations between radiological findings, hospitalization, age, RA duration, pulmonary function tests (PFT) and survival. MATERIALS AND METHODS: HRCTs from 60 RA-ILD patients were independently evaluated and re-categorized into usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP), organizing pneumonia (OP), diffuse alveolar damage (DAD) and unclassified subtypes by two radiologists...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29394349/the-impact-of-coexisting-lung-diseases-on-outcomes-in-patients-with-pathological-stage-i-non-small-cell-lung-cancer
#14
Hiroyuki Tao, Hideko Onoda, Kazunori Okabe, Tsuneo Matsumoto
OBJECTIVES: Cigarette smoking is a well-known cause of interstitial lung disease (ILD), pulmonary emphysema and lung cancer. Coexisting pulmonary disease can affect prognosis in patients with lung cancer. The aim of this study was to determine the influence of pulmonary disease on outcomes in patients with a smoking history who had undergone surgery for pathological Stage I non-small-cell lung cancer. METHODS: Medical records of 257 patients with a smoking history who underwent surgery for pathological Stage I non-small-cell lung cancer between June 2009 and December 2014 were reviewed...
January 31, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29344688/inflammation-based-prognostic-score-predicts-postoperative-survival-of-patients-with-interstitial-pneumonia-after-undergoing-lung-cancer-resection
#15
Satoru Kobayashi, Yuji Matsumura, Yoko Karube, Morimichi Nishihira, Takashi Inoue, Osamu Araki, Sumiko Maeda, Masayuki Chida
OBJECTIVES: Idiopathic interstitial pneumonias (IIPs) are associated with an increased risk of lung cancer. Glasgow prognostic score (GPS), which uses serum C-reactive protein (CRP) and albumin levels to indicate systemic inflammatory response and nutrition level, has been reported to be a predictor of overall survival in patients with various types of cancer. We evaluated the usefulness of GPS for prediction of survival of patients with both lung cancer and IIPs following a lung resection procedure...
January 17, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29330249/is-it-idiopathic-pulmonary-fibrosis-or-not
#16
REVIEW
Mary Salvatore, Genta Ishikawa, Maria Padilla
Pulmonary fibrosis is not uncommon. Usual interstitial pneumonitis (UIP)/idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic pulmonary fibrotic diseases and has the worst prognosis with a mean life expectancy of 3.8 years. The American Thoracic Society has provided guidelines for the accurate diagnosis of IPF.In 2014, 2 antifibrotic medications were approved in the United States that target the multiple fibrotic pathways of UIP, which increased the need for early and accurate diagnosis of IPF...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29320807/overlap-of-interstitial-pneumonia-with-autoimmune-features-with-undifferentiated-connective-tissue-disease-and-contribution-of-uip-to-mortality
#17
Bryan T Kelly, Teng Moua
BACKGROUND AND OBJECTIVE: Criteria for interstitial pneumonia with autoimmune features (IPAF) were recently established for research purposes in a joint statement from the European Respiratory Society (ERS) and American Thoracic Society (ATS). We reviewed the utility of these criteria in patients previously diagnosed as broadly defined undifferentiated connective tissue disease (UCTD) and noted overlapping IPAF findings. Additional review was given to IPAF patients with usual interstitial pneumonia (UIP) on histopathology or radiology in terms of survival and outcome...
January 10, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29304775/thin-section-computed-tomography-determined-usual-interstitial-pneumonia-pattern-affects-the-decision-making-process-for-resection-in-newly-diagnosed-lung-cancer-patients-a-retrospective-study
#18
Naozumi Hashimoto, Akira Ando, Shingo Iwano, Koji Sakamoto, Shotaro Okachi, Asuka Matsuzaki, Yu Okada, Kenji Wakai, Kohei Yokoi, Yoshinori Hasegawa
BACKGROUND: There is only limited information on the impact of thin-section computed tomography (TSCT)-determined usual interstitial pneumonia (UIP) pattern in the decision-making for resection in newly diagnosed lung cancer patients. METHODS: In this retrospective analysis, data were reviewed from 499 newly diagnosed lung cancer patients who received bronchoscopy between 2010 and 2014. The clinical impact of TSCT-determined UIP pattern on the decision-making process for resection in this cohort was evaluated...
January 5, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29289932/vaccination-marketing-by-private-healthcare-sector-glaring-malpractices
#19
LETTER
Vipin M Vashishtha
No abstract text is available yet for this article.
January 2018: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/29286173/ipf-and-cpfe-the-two-different-entities-or-two-different-presentations-of-the-same-disease
#20
Sylwia Kwiatkowska
In this article the co-existence of pulmonary emphysema with lung fibrosis of typical pattern and distribution for usual interstitial pneumonia (UIP) was compared with idiopathic pulmonary fibrosis (IPF) alone. Author discusses the etiopathogenesis of these diseases, differences in signaling pathways and the role of senescent cells. Moreover, clinical course, pulmonary function tests as well as main complications are reviewed. However, the lack of well-established diagnostic criteria for CPFE along with mainly retrospective character of the studies make current knowledge about this entity rather deficient...
2018: Advances in Respiratory Medicine
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