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https://www.readbyqxmd.com/read/28634618/ct-and-mri-findings-in-focal-eosinophilic-infiltration-of-the-liver
#1
Bao-Liang Guo, Qiu-Gen Hu, Fu-Sheng Ouyang, Bin Zhang, Yu-Hao Dong, Xiao-Ning Luo, Zhou-Yang Lian, Shui-Xing Zhang
OBJECTIVES: To investigate the findings of computed tomography (CT) and magnetic resonance imaging (MRI) of focal eosinophilic infiltration (FEI) of the liver. METHODS: A retrospective study including 29 patients with confirmed FEI of the liver was performed. We evaluated the lesions' number, distribution, size, shape, margin, attenuation or signal intensity characteristics, the enhancement pattern, and some special features. Spearman correlation analysis was used to analyze the correlation between the number of lesions and the eosinophil counts in peripheral blood...
June 20, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28626584/enteric-multiplex-pcr-panels-a-new-diagnostic-tool-for-amoebic-liver-abscess
#2
T Weitzel, J Cabrera, R Rosas, L M Noriega, G Schiappacasse, V Vollrath, L Porte
Invasive amoebiasis is a life-threatening infection requiring immediate detection and treatment. However, diagnosis is challenging because conventional methods such as light microscopy and serology are unreliable. Molecular techniques are therefore considered the new diagnostic reference standard, but most of the developed assays are research tools and not widely available. Recently commercial multiplex PCR panels have been introduced which permit the simultaneous detection of multiple enteric pathogens including Entamoeba histolytica in stool samples...
July 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/28609188/subtraction-images-of-gadoxetic-acid-enhanced-mri-effect-on-the-diagnostic-performance-for-focal-hepatic-lesions-in-patients-at-risk-for-hepatocellular-carcinoma
#3
Sang Hyun Choi, So Yeon Kim, Seung Soo Lee, Ju Hyun Shim, Jae Ho Byun, Seunghee Baek, Moon-Gyu Lee
OBJECTIVE: The purpose of this study is to evaluate the effect of subtraction images of gadoxetic acid-enhanced MRI on the image interpretation of focal hepatic lesions in patients at risk for hepatocellular carcinoma (HCC). MATERIALS AND METHODS: We retrospectively analyzed 255 malignant nodules from 233 patients with chronic hepatitis or liver cirrhosis (187 men and 46 women; mean age, 55.2 years) who underwent preoperative gadoxetic acid-enhanced MRI and surgical resection...
June 13, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28607606/diagnostic-value-of-gd-eob-dtpa-mri-for-hepatocellular-adenoma-a-meta-analysis
#4
Yongfei Guo, Wenjuan Li, Zhinan Xie, Yi Zhang, Yijie Fang, Wenli Cai, Guobin Hong
Objective: This study aimed to systematically review the gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-DTPA-MRI) findings of hepatocellular adenoma (HCA), especially focusing on the diagnostic value of low signal intensity (SI) in the hepatocyte-phase (HBP) for differentiating HCA from focal nodular hyperplasia (FNH). Methods: A thorough literature search was conducted in PubMed, Excerpta Medica Database (EMBASE) and China National Knowledge Infrastructure databases (CNKI) to identify studies evaluating Gd-EOB-DTPA-MRI presentations of HCA...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28605060/modelling-the-benefits-and-harms-of-surveillance-for-hepatocellular-carcinoma-information-to-support-informed-choices
#5
Eleanor J Taylor, Rebecca L Jones, J Ashley Guthrie, Ian A Rowe
Surveillance by ultrasonography for hepatocellular carcinoma (HCC) for individuals with cirrhosis is recommended. There is debate regarding the effectiveness of surveillance in reducing mortality and there is little information on the harms available to patients considering surveillance. The aim of this study was to provide estimates of both the benefit and harms of surveillance. A Markov model was built to simulate outcomes of individuals entering surveillance. Following identification of a focal lesion by ultrasound surveillance further investigations were defined by the EASL-EORTC recall policy...
June 12, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28583643/utility-of-t1-weighted-mri-as-a-predictor-of-liver-lesion-visibility-on-ultrasound-a-clinical-tool-to-determine-feasibility-of-ultrasound-guided-percutaneous-interventions
#6
Timothy L Miao, Ania Z Kielar, Rebecca M Hibbert, Nicola Schieda
PURPOSE: To determine the utility of fat-suppressed T1-weighted gradient recalled echo (FS-T1W-GRE) MRI to predict visibility of focal liver lesions (FLL) on abdominal ultrasound (US). MATERIALS AND METHODS: With IRB approval, between 2010 and 2013, 109 patients (28.4% females, age 66.9±10.9years) with 177 FLL (hepatocellular carcinoma=132, metastases=44, other=1) underwent MRI and prospective, radiologist-performed treatment-planning US (to determine eligibility for US-guided ablation)...
May 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28583364/a-pictorial-review-of-hepatobiliary-magnetic-resonance-imaging-with-hepatocyte-specific-contrast-agents-uses-findings-and-pitfalls-of-gadoxetate-disodium-and-gadobenate-dimeglumine
#7
REVIEW
Elena P Scali, Triona Walshe, Hina Arif Tiwari, Alison C Harris, Silvia D Chang
Magnetic resonance imaging (MRI) has a well-established role as a highly specific and accurate modality for characterizing benign and malignant focal liver lesions. In particular, contrast-enhanced MRI using hepatocyte-specific contrast agents (HSCAs) improves lesion detection and characterization compared to other imaging modalities and MRI techniques. In this pictorial review, the mechanism of action of gadolinium-based MRI contrast agents, with a focus on HSCAs, is described. The clinical indications, protocols, and emerging uses of the 2 commercially available combined contrast agents available in the United States, gadoxetate disodium and gadobenate dimeglumine, are discussed...
June 2, 2017: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/28582472/18f-fdg-silicon-photomultiplier-pet-ct-a-pilot-study-comparing-semi-quantitative-measurements-with-standard-pet-ct
#8
Lucia Baratto, Sonya Young Park, Negin Hatami, Guido Davidzon, Shyam Srinivas, Sanjiv Sam Gambhir, Andrei Iagaru
PURPOSE: To evaluate if the new Discovery Molecular Insights (DMI) PET/CT scanner provides equivalent results compared to the standard of care PET/CT scanners (GE Discovery 600 or GE Discovery 690) used in our clinic and to explore any possible differences in semi-quantitative measurements. METHODS: The local Institutional Review Board approved the protocol and written informed consent was obtained from each patient. Between September and November 2016, 50 patients underwent a single 18F-FDG injection and two scans: the clinical standard PET/CT followed immediately by the DMI PET/CT scan...
2017: PloS One
https://www.readbyqxmd.com/read/28562394/diagnostic-accuracy-of-contrast-enhanced-ultrasound-for-the-differential-diagnosis-of-hepatocellular-carcinoma-esculap-versus-ceus-li-rads
#9
Barbara Schellhaas, Ruediger S Görtz, Lukas Pfeifer, Christian Kielisch, Markus F Neurath, Deike Strobel
OBJECTIVE: A comparison is made of two contrast-enhanced ultrasound (CEUS) algorithms for the diagnosis of hepatocellular carcinoma (HCC) in high-risk patients: Erlanger Synopsis of Contrast-enhanced Ultrasound for Liver lesion Assessment in Patients at Risk (ESCULAP) and American College of Radiology Contrast-Enhanced Ultrasound-Liver Imaging Reporting and Data System (ACR-CEUS-LI-RADSv.2016). PATIENTS AND METHODS: Focal liver lesions in 100 high-risk patients were assessed using both CEUS algorithms (ESCULAP and CEUS-LI-RADSv...
May 30, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28551024/eus-guided-fine-needle-core-liver-biopsy-using-a-novel-19g-needle-with-modified-one-pass-one-actuation-wet-suction-technique
#10
Jose Nieto, Huda Khaleel, Youssef Challita, Melissa Jimenez, Todd H Baron, Laura Walters, Kelli Hathaway, Ketul Patel, Ali Lankarani, Michael Herman, David Holloman, Sammy Saab
BACKGROUND AND AIMS: EUS-guided fine-needle core biopsy is a safe and effective technique for diagnosis of focal liver lesions. However, data are limited in its role in parenchymal disease. We evaluated the utility of EUS-guided parenchymal liver biopsies (EUS-LB) with a modified one pass wet suction technique (EUS-MLB) in patients with unexplained increase in liver associated tests. METHODS: We retrospectively evaluated the safety and efficacy of EUS-MLB in patients referred for EUS to evaluate for biliary obstruction and pancreatic disorders, but with associated unexplained liver tests...
May 24, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28547764/visibility-of-focal-liver-lesions-comparison-between-kupffer-phase-of-ceus-with-sonazoid-and-hepatobiliary-phase-of-gadoxetic-acid-enhanced-mri
#11
Woo Young Yang, Hee Sun Park, Young Jun Kim, Mi Hye Yu, Sung Il Jung, Hae Jeong Jeon
BACKGROUND: To investigate the agreement between Kupffer phase of Sonazoid contrast-enhanced sonography (CEUS) and hepatobiliary phase of gadoxetic acid-enhanced MRI in the evaluation of focal liver lesions (FLLs). METHODS: One hundred fifty-four FLLs in 154 patients who underwent both Sonazoid CEUS and gadoxetic acid-enhanced liver MRI were included in this retrospective study. FLL visibility on the Kupffer-phase images was graded as one (invisible or isoenhancing), two (vaguely visible or vaguely hypoenhancing), or three (clearly visible or clearly hypoenhancing), and that on the hepatobiliary-phase images of MRI was graded as one (invisible or hyper/isointense), two (vaguely visible or weakly hypointense), or three (clearly visible or strongly hypointense)...
May 26, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28531871/echinococcosis-mimicking-liver-malignancy-a-case-report
#12
Radek Pohnan, Miroslav Ryska, Vladislav Hytych, Radek Matej, Petr Hrabal, Jiri Pudil
INTRODUCTION: Human Alveolar Echinococcosis - Alveolar Hydatid disease (AE) is an omitted zoonotic infection presenting with focal liver lesions. Cause of AE is a larval stage of Echinococcus multilocularis tapeworms. CASE PRESENTATION: In this report an extraordinary case of a 38 year-old female examined due to 2 liver tumors and 2 pulmonary nodules is described. The patient underwent pulmonary and liver surgery for suspected advanced cholangiocellular carcinoma and surprisingly AE was found...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28527201/contrast-enhanced-ultrasound-ceus-prediction-of-focal-liver-lesions-in-patients-after-liver-transplantation-in-comparison-to-histopathology-results
#13
J Rübenthaler, K J Paprottka, E Hameister, K Hoffmann, N Joiko, M Reiser, R Rjosk-Dendorfer, D A Clevert
PURPOSE: To investigate the value of contrast-enhanced ultrasound (CEUS) in histologic prediction of focal liver lesions after liver transplantation. MATERIALS AND METHODS: 10 focal liver lesions in 10 patients after liver transplantation were scanned using CEUS and the CEUS results were compared with the histopathological results. RESULTS: Among 10 focal liver lesions, 7 proofed to be histopathological benign and 3 lesions proofed to be histopathological malignant...
May 19, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28506367/immunohistochemistry-in-the-diagnosis-of-hepatocellular-carcinoma
#14
REVIEW
Won-Tak Choi, Sanjay Kakar
Hepatocellular carcinoma (HCC) can be difficult to distinguish from its mimics, including metastatic tumor, benign hepatocellular lesion, and high-grade dysplastic nodule, especially when limited biopsy material is available. Hence, the judicious use of immunohistochemical stains is necessary to establish a correct diagnosis. This article describes advantages and disadvantages of immunohistochemical markers that are most commonly used to distinguish between these lesions. Diagnostic workup of malignant liver mass (HCC and its histologic variants vs metastatic tumor) as well as well-differentiated hepatocellular lesion (well-differentiated HCC vs focal nodular hyperplasia vs hepatocellular adenoma) is also discussed...
June 2017: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/28497069/characterization-of-focal-liver-lesions-indistinctive-on-b-mode-ultrasound-benefits-of-contrast-enhanced-ultrasound
#15
Yi Dong, Feng Mao, Jiaying Cao, Peili Fan, Wen-Ping Wang
Aim. The aim of this prospective study was to evaluate the additional value of contrast-enhanced ultrasound (CEUS) in identifying and characterizing of focal liver lesions (FLLs) that are indistinctive on B mode ultrasound (BMUS). Methods. The study focused on 70 consecutive patients (male 46, female 24; mean age, 53.1 years ± 10). All lesions were detected by MRI but could not be clearly visualized by BMUS. CEUS was performed by injected SonoVue® (Bracco Imaging Spa, Milan, Italy) as a quick bolus into the antecubital vein...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28495460/dual-energy-computed-tomography-for-the-detection-of-focal-liver-lesions
#16
K N Lago, J Vallejos, C Capuñay, E Salas, E Reynoso, J B Carpio, P M Carrascosa
OBJECTIVE: To qualitatively and quantitatively explore the spectral study of focal liver lesions, comparing it with the usual polychromatic assessment with single-energy computed tomography. MATERIAL AND METHODS: We prospectively studied 50 patients with at least one focal liver lesion who were referred for abdominal multidetector computed tomography with intravenous contrast material. The portal phase was acquired with dual energy sources. The density of the lesions and of the surrounding liver parenchyma was measured both in the baseline polychromatic acquisition and in the posterior monochromatic reconstructions at 40 keV, 70 keV, and 140 keV...
May 8, 2017: Radiología
https://www.readbyqxmd.com/read/28493503/liver-of-the-fish-gymnotus-inaequilabiatus-and-nematode-larvae-infection-histochemical-features-and-expression-of-proliferative-cell-nuclear-antigen
#17
B Sayyaf Dezfuli, M Manera, J A DePasquale, F Pironi, L Giari
Histopathological lesions due to third-larval stage of nematode Brevimulticaecum sp. within the liver of a subpopulation of 31 Gymnotus inaequilabiatus from the Pantanal Region (Brazil) were studied with histochemical and immunohistochemical methods. In 93.5% of fish, livers harboured nematode larvae and the intensity of infection ranged from 8 to 293. In livers with highest number of larvae, the hepatic tissue was occupied primarily by the nematodes. Each larva was encircled by focal inflammatory granulomatous reaction...
May 11, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28491877/nodular-regenerative-hyperplasia-a-case-of-rare-prognosis
#18
Mindy Lee, Manhal Izzy, Ashwin Akki, Kathryn Tanaka, Harmit Kalia
Introduction: Nodular regenerative hyperplasia (NRH) is a known etiology of noncirrhotic portal hypertension. Cases of biopsy-proven NRH in human immunodeficiency virus (HIV)-positive patients have been described. While these patients often have normal synthetic liver function, several reports described disease progression to liver failure. Case: We here present a 26-year-old woman with history of congenital HIV on antiretroviral therapy complicated by Pneumocystis carinii pneumonia at age 14. CD4 counts have been >300 with undetectable viral load...
January 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28486977/rapid-cartesian-versus-radial-acquisition-comparison-of-two-sequences-for-hepatobiliary-phase-mri-at-3-tesla-in-patients-with-impaired-breath-hold-capabilities
#19
Johannes Budjan, Philipp Riffel, Melissa M Ong, Stefan O Schoenberg, Ulrike I Attenberger, Daniel Hausmann
BACKGROUND: Hepatocyte-specific gadolinium based contrast agents (HSCA) provide substantial information for the classification of liver lesions in magnetic resonance imaging (MRI). However, breathing artifacts which reduce image quality and diagnostic confidence of hepatobiliary phase acquisitions are regularly observed in clinical routine. The aim of this study was to evaluate two approaches to reduce breathing artifacts for hepatobiliary phase imaging. METHODS: Twenty minutes after administration of a HSCA (gadoxetic acid), a T1-weighted VIBE sequence with radial k-space sampling (radialVIBE, 180 s acquisition time in free breathing) and a highly accelerated Cartesian VIBE with Dixon fat separation (CD-VIBE, CAIPIRINHA acceleration with r = 2 × 2, breath-hold 8-10 s) were acquired in 35 patients (12 female, 57 ± 13 years), who showed breath-holding difficulties in early phases of the examinations...
May 9, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28486156/typical-and-atypical-benign-liver-lesions-a-review
#20
REVIEW
Mohammad Ali Husainy, Farhina Sayyed, Praveen Peddu
Focal liver lesions are routinely encountered by clinical radiologists and represent a wide spectrum of pathology. Majority of these lesions are likely to be benign in nature, especially in the absence of chronic liver disease or primary cancer. A radiologist must be aware of common and uncommon imaging features of benign lesions across the various imaging modalities. This review discusses pathognomonic imaging features of common benign focal liver lesions seen on ultrasound, computed tomography and magnetic resonance, and adds to existing knowledge with the recent updates to have emerged in this area...
July 2017: Clinical Imaging
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