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https://www.readbyqxmd.com/read/28087475/immunohistochemical-approach-for-the-diagnosis-of-a-liver-mass-on-small-biopsy-specimens
#1
Won-Tak Choi, Rageshree Ramachandran, Sanjay Kakar
Well-differentiated hepatocellular carcinoma (HCC) shares overlapping histological features with benign hepatocellular lesions, including hepatocellular adenoma (HCA) and focal nodular hyperplasia (FNH) in non-cirrhotic liver, and with high-grade dysplastic nodule (HGDN) in cirrhotic liver. Several metastatic tumors, such as neuroendocrine tumor, renal cell carcinoma, adrenocortical carcinoma, melanoma, and epithelioid angiomyolipoma, can be indistinguishable from HCC on histologic grounds. Since this distinction has important therapeutic implications, judicious use of immunohistochemical markers plays an important role in establishing an accurate diagnosis, especially when limited material of tumor is available on cell block or a small core biopsy...
January 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/28078512/the-role-of-apparent-diffusion-coefficient-values-in-characterization-of-solid-focal-liver-lesions-a-prospective-and-comparative-clinical-study
#2
Dawei Yang, Jie Zhang, Dan Han, Erhu Jin, Zhenghan Yang
We evaluated and compared the diagnostic accuracy (DA) of apparent diffusion coefficient (ADC) values with that of lesion-to-liver ADC ratios in the characterization of solid focal liver lesions (FLLs). This prospective study was approved by the Institutional Human Ethics Board, after waiving written informed consent. Diffusion-weighted imaging and other routine magnetic resonance imaging were performed on 142 consecutive patients with suspected liver disease. The mean ADC values and lesion-to-liver ADC ratios were compared between benign and malignant solid FLLs...
January 4, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28078508/prioritization-of-liver-mri-for-distinguishing-focal-lesions
#3
Qinghua Su, Shusheng Bi, Xuedong Yang
Liver cancer is one of the leading causes of cancer-related mortality worldwide. Magnetic resonance imaging (MRI) is a non-invasive imaging technique that is often used by radiologists for diagnosis and surgical planning. Analysis of a large amount of liver MRI data for each patient limits the radiologist's efficiency and may lead to misdiagnoses. The redundant MRI data, especially from dynamic contrast enhanced (DCE) sequences, is also a bottleneck in transmitting the images via the internet or PACS for remote consultancy in a reasonable amount of time...
January 4, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28069221/effects-of-different-hydrostatic-pressure-on-lesions-in-ex-vivo-bovine-livers-induced-by-high-intensity-focused-ultrasound
#4
Min He, Zhiqiang Zhong, Xing Li, Xiaobo Gong, Zhibiao Wang, Faqi Li
It is well-known that acoustic cavitation associated with the high intensity focused ultrasound (HIFU) treatment often would change the morphology and size of lesions in its treatment. In most studies reported in literature, high ambient hydrostatic pressure was used to suppress the cavitation completely. Investigation of the effects by varying the ambient hydrostatic pressure (Pstat) is still lacking. In this paper, the effects of HIFU on lesions in ex vivo bovine liver specimens under various Pstat are systematically investigated...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28062263/the-natural-history-of-streptozotocin-stimulated-non-alcoholic-steatohepatitis-mice-followed-by-gd-eob-dtpa-enhanced-mri-comparison-with-simple-steatosis-mice
#5
Hiroyuki Akai, Shigeru Kiryu, Yasunori Ohta, Koichiro Yasaka, Yoshiyasu Nakano, Yusuke Inoue, Kuni Ohtomo
PURPOSE: To clarify the development of HCC, temporal change of steatosis and Gd-EOB-DTPA enhancement of non-alcoholic steatohepatitis (NASH) model mice by magnetic resonance imaging (MRI). MATERIALS AND METHODS: All animal experiments were approved by the institution's Animal Research Committee. MRI was performed on six NASH and six simple steatosis (SS) model mice every 2weeks from the ages of 8weeks to 16weeks. The sequential changes in the number and size of the focal liver lesions detected on Gd-EOB-DTPA-enhanced MRI were evaluated...
January 3, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28058027/complete-spontaneous-regression-of-giant-focal-nodular-hyperplasia-of-the-liver-magnetic-resonance-imaging-evaluation-with-hepatobiliary-contrast-media
#6
Giuseppe Mamone, Settimo Caruso, Kelvin Cortis, Roberto Miraglia
Focal nodular hyperplasia (FNH) of the liver is a benign lesion occurring in 0.6%-3% of the general population that probably reflects a local hyperplastic response of hepatocytes to a vascular abnormality. Most lesions are diagnosed incidentally and the natural history of the disease remains largely unknown. It has been shown that most FNH remain stable, or even regress, over a long follow-up period. We present a patient with FNH of the liver who was followed up for 7 years. A 26-year-old woman with a 5-year history of oral contraceptive use was referred to our hospital in February 2005 for further examination of a liver tumour...
December 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28027748/intra-individual-comparison-of-caipirinha-vibe-technique-with-conventional-vibe-sequences-in-contrast-enhanced-mri-of-focal-liver-lesions
#7
M H Albrecht, B Bodelle, A Varga-Szemes, P Dewes, A M Bucher, B D Ball, C N De Cecco, U J Schoepf, X Zhu, S Zangos, T Gruber-Rouh, J L Wichmann, T Lehnert, T J Vogl
PURPOSE: To evaluate the impact of controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA) volume interpolated breath-hold examination (VIBE) magnetic resonance imaging (MRI) technique on image quality, reader confidence, and inter-observer agreement for the assessment of focal liver lesions in comparison with the standard VIBE approach. MATERIAL AND METHODS: In this IRB-approved intra-individual comparison study, abdominal arterial and portal-venous contrast-enhanced MRI studies were retrospectively analyzed in 38 patients with malignant liver lesions...
January 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28012338/an-unusual-case-of-left-hepatectomy-for-focal-nodular-hyperplasia-fnh-linked-to-the-use-of-anabolic-androgenic-steroids-aass
#8
Angela Romano, Michele Grassia, Giuseppe Esposito, Marianna Petrillo, Modestino Pezzella, Francesco Maria Romano, Francesco Esposito, Francesco Torelli, Natale Di Martino
INTRODUCTION: Focal Nodular Hyperplasia (FNH) is the second most common benign tumor of the liver. Clinically FNH is asymptomatic and discovered incidentally . The pathogenesis is unclear; FNH is usually asymptomatic. When the tumor is large, it may be painful. Surgery is recommended only in the case of complications such as compression of adjacent organs, lesion progression with tumor size >5cm and presence of symptoms. PRESENTATION OF CASE: A 30 years old man, was evaluated during a routine visit, for diffuse abdominal pain and weight loss; Abdominal ultrasound showed no evidence of biliary obstruction but the US shows a hypoechoic, well defined focal lesion in the left liver...
November 3, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28011890/idiopathic-myelofibrosis-with-disseminated-hepatosplenic-mesenteric-renal-and-pulmonary-extramedullary-haematopoeisis-portal-hypertension-and-tuberculosis-initial-presentation-and-2%C3%A2-years-follow-up
#9
Ananya Panda, Sheragaru Hanumanthappa Chandrashekhara, Aruna Nambirajan, Pravas Mishra
A 35-year-old man with a 12-year history of idiopathic myelofibrosis (IMF) presented in 2014 with fatigue and abdominal distension. CT scan revealed massive hepatosplenomegaly with focal splenic lesions, soft tissue around renal pelvis, mesenteric masses compressing bowel loops and perilymphatic nodules in lungs. There was portal hypertension, ascites, pleural effusion, bilateral psoas abscesses and necrotic retroperitoneal lymphadenopathy. MRI additionally revealed hypointense periportal infiltrative lesions in liver, not seen on CT scan...
December 23, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/28002045/improved-hepatic-arterial-fraction-estimation-using-cardiac-output-correction-of-arterial-input-functions-for-liver-dce-mri
#10
Manil D Chouhan, Alan Bainbridge, David Atkinson, Shonit Punwani, Rajeshwar Mookerjee, Mark Lythgoe, Stuart Taylor
Liver dynamic contrast enhanced (DCE) MRI pharmacokinetic modelling could be useful in the assessment of diffuse liver disease and focal liver lesions, but is compromised by errors in arterial input function (AIF) sampling. In this study, we apply cardiac output correction to arterial input functions (AIFs) for liver dynamic contrast enhanced (DCE) MRI and investigate the effect on dual-input single compartment hepatic perfusion parameter estimation and reproducibility. Thirteen healthy volunteers (28.7±1...
December 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27999887/imaging-patterns-and-focal-lesions-in-fatty-liver-a-pictorial-review
#11
REVIEW
Sudhakar K Venkatesh, Tiffany Hennedige, Geoffrey B Johnson, David M Hough, Joel G Fletcher
Non-alcoholic fatty liver disease is the most common cause of chronic liver disease and affects nearly one-third of US population. With the increasing trend of obesity in the population, associated fatty change in the liver will be a common feature observed in imaging studies. Fatty liver causes changes in liver parenchyma appearance on imaging modalities including ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) and may affect the imaging characteristics of focal liver lesions (FLLs)...
December 20, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27993534/assessment-of-the-link-between-quantitative-biexponential-diffusion-weighted-imaging-and-contrast-enhanced-mri-in-the-liver
#12
Hildebrand Dijkstra, Matthijs Oudkerk, Peter Kappert, Paul E Sijens
PURPOSE: To investigate if intravoxel incoherent motion (IVIM) modeled diffusion-weighted imaging (DWI) can be linked to contrast-enhanced (CE-)MRI in liver parenchyma and liver lesions. METHODS: Twenty-five patients underwent IVIM-DWI followed by multiphase CE-MRI using Gd-EOB-DTPA (n=20) or Gd-DOTA (n=5) concluded with IVIM-DWI. Diffusion (Dslow), microperfusion (Dfast), its fraction (ffast), wash-in-rate (Rearly) and late-enhancement-rate (Rlate) of Gd-EOB-DTPA were calculated voxel-wise for the liver...
December 18, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27986175/contrast-enhanced-ultrasound-in-focal-liver-lesions-where-do-we-stand
#13
Tommaso Vincenzo Bartolotta, Federica Vernuccio, Adele Taibbi, Roberto Lagalla
Contrast-enhanced ultrasound (CEUS) represents a significant breakthrough in sonography, and it is being increasingly used for the evaluation of focal liver lesions (FLLs). Currently, CEUS is included as a part of the suggested diagnostic workup of FLLs, resulting in a better patient management and delivering cost-effective therapy. After a brief technical note, contrast-enhancement patterns of different types of benign and malignant FLLs, along with hepatic pseudolesions, are described and discussed based on our experience and literature data...
December 2016: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/27986174/avoiding-pitfalls-in-the-interpretation-of-gadoxetic-acid-enhanced-magnetic-resonance-imaging
#14
Marco Dioguardi Burgio, Maxime Ronot, Luisa Paulatto, Sylvain Terraz, Valérie Vilgrain, Giuseppe Brancatelli
Gadoxetic acid is extensively used in the following 3 main clinical situations: characterization of small nodules in patients with cirrhosis, preoperative staging of liver metastases, and characterization of incidentally discovered focal liver lesions. Owing to the rapid entry of gadoxetic acid into hepatocytes, the traditional features of liver tumors are modified on magnetic resonance (MR) imaging, especially during delayed phase sequences. Thus, although the added value of gadoxetic acid for the detection and characterization of focal liver lesions is now clear, its unique pharmacokinetics as well as the presence of mimicking and atypical lesions may lead to misdiagnoses...
December 2016: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/27986170/imaging-of-hepatic-focal-nodular-hyperplasia-pictorial-review-and-diagnostic-strategy
#15
Marco Dioguardi Burgio, Maxime Ronot, Giuseppe Salvaggio, Valérie Vilgrain, Giuseppe Brancatelli
Focal nodular hyperplasia (FNH) is the second most common benign solid liver lesion after hemangioma, occurring more frequently in young women. The prime differential diagnoses include hepatocellular adenoma, hepatocellular carcinoma, and hypervascular metastasis. As the management of FNH is typically conservative, imaging plays a key role in diagnostic pathway, and misdiagnosis may have a major clinical effect. In this article, we describe the ultrasound, computed tomography, and magnetic resonance imaging features of FNH, underlining the importance of typical radiological features that allow a specific noninvasive diagnosis...
December 2016: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/27936106/feasibility-of-10-minute-delayed-hepatocyte-phase-imaging-using-a-30%C3%A2-flip-angle-in-gd-eob-dtpa-enhanced-liver-mri-for-the-detection-of-hepatocellular-carcinoma-in-patients-with-chronic-hepatitis-or-cirrhosis
#16
Inhwan Jeon, Eun-Suk Cho, Joo Hee Kim, Dae Jung Kim, Jeong-Sik Yu, Jae-Joon Chung
OBJECTIVES: To compare 10-minute (min) delayed hepatocyte phase imaging (HPI) using a 30° flip angle (FA) (10m-FA30) and 20-min delayed HPI using a 10° FA (20m-FA10) or 30° FA (20m-FA30) in Gd-EOB-DTPA-enhanced MRI in patients with chronic hepatitis or cirrhosis, in terms of lesion-to-liver contrast-to-noise ratio (CNR) for hepatocellular carcinoma (HCC) and detection sensitivity for focal hepatic lesions (FHLs). MATERIALS AND METHODS: One hundred and four patients with 168 HCCs and 55 benign FHLs who underwent Gd-EOB-DTPA-enhanced MRI with 10m-FA30, 20m-FA10, and 20m-FA30 were enrolled...
2016: PloS One
https://www.readbyqxmd.com/read/27913330/ex-vivo-hifu-experiments-using-a-32-times-32-element-cmut-array
#17
Hyo-Seon Yoon, Chienliu Chang, Ji Hoon Jang, Anshuman Bhuyan, Jung Woo Choe, Amin Nikoozadeh, Ronald D Watkins, Douglas N Stephens, Kim Butts Pauly, Butrus T Khuri-Yakub
High-intensity focused ultrasound (HIFU) has been used as noninvasive treatment for various diseases. For these therapeutic applications, capacitive micromachined ultrasonic transducers (CMUTs) have advantages that make them potentially preferred transducers over traditional piezoelectric transducers. In this paper, we present the design and the fabrication process of an 8 ×8 -mm (2) 32 ×32 -element 2-D CMUT array for HIFU applications. To reduce the system complexity for addressing the 1024 transducer elements, we propose to group the CMUT array elements into eight HIFU channels based on the phase delay from the CMUT element to the targeted focal point...
December 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27907063/evaluation-of-focal-liver-reaction-after-proton-beam-therapy-for-hepatocellular-carcinoma-examined-using-gd-eob-dtpa-enhanced-hepatic-magnetic-resonance-imaging
#18
Shigeyuki Takamatsu, Kazutaka Yamamoto, Yoshikazu Maeda, Mariko Kawamura, Satoshi Shibata, Yoshitaka Sato, Kazuki Terashima, Yasuhiro Shimizu, Yuji Tameshige, Makoto Sasaki, Satoko Asahi, Tamaki Kondou, Satoshi Kobayashi, Osamu Matsui, Toshifumi Gabata
BACKGROUND: Proton beam therapy (PBT) achieves good local control for hepatocellular carcinoma (HCC), and toxicity tends to be lower than for photon radiotherapy. Focal liver parenchymal damage in radiotherapy is described as the focal liver reaction (FLR); the threshold doses (TDs) for FLR in the background liver have been analyzed in stereotactic ablative body radiotherapy and brachytherapy. To develop a safer approach for PBT, both TD and liver volume changes are considered clinically important in predicting the extent of damage before treatment, and subsequently in reducing background liver damage...
2016: PloS One
https://www.readbyqxmd.com/read/27903597/impact-of-organic-cation-transporters-oct-slc22a-on-differential-diagnosis-of-intrahepatic-lesions
#19
Michele Visentin, Belle V van Rosmalen, Christian Hiller, Matthanja Bieze, Lia Hofstetter, Joanne Verheij, Gerd A Kullak-Ublick, Hermann Koepsell, Saffire Sks Phoa, Ikumi Tamai, Roelof J Bennink, Thomas M van Gulik, Bruno Stieger
Positron emission tomography (PET) using the cationic compound [(18)F]fluoromethylcholine (FCH) enhances the sensitivity for non-invasive classification of hepatic tumours due to peculiar patterns of accumulation. The underlying transporters are not known. We aim to identify the carriers mediating uptake of FCH in liver and to correlate their expression pattern with PET intrahepatic signal distribution to clarify the role of membrane transporters in FCH accumulation. FCH transport was characterized in cells overexpressing organic cation transporters (OCTs)...
November 30, 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27887203/contrast-enhanced-ultrasound-features-of-hepatic-cystadenoma-and-hepatic-cystadenocarcinoma
#20
Yi Dong, Wen-Ping Wang, Feng Mao, Mei Fan, Andre Ignee, Carla Serra, Zeno Sparchez, Ioan Sporea, Barbara Braden, Christoph F Dietrich
OBJECTIVE: Hepatic (biliary) cystic tumor (HBCT) is a rare focal cystic liver lesion, which has been rarely described in the literature. In our current multicenter, retrospective study, we aimed to analyze contrast enhanced ultrasound (CEUS) features and its diagnostic performance in histologically proved HBCT. MATERIAL AND METHODS: Twenty-three patients with single HBCT were retrospectively analyzed. Histologically, 17 (73.9%) were benign hepatic (biliary) cystadenoma (HBCA), 6 (26...
March 2017: Scandinavian Journal of Gastroenterology
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