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https://www.readbyqxmd.com/read/29353268/non-invasive-diagnostic-criteria-for-hepatocellular-carcinoma-in-hepatitis-b-virus-endemic-areas-is-cirrhosis-indispensable
#1
Xiao-Wen Huang, Bing Liao, Yang Huang, Jin-Yu Liang, Quan-Yuan Shan, Shun-Li Shen, Xiao-Yan Xie, Ming-de Lu, Li-da Chen, Wei Wang
AIM: To confirm whether cirrhosis is indispensable for the non-invasive diagnostic criteria for hepatocellular carcinoma (HCC) in hepatitis B virus (HBV)-endemic areas. METHODS: Between January 2014 and December 2014, a total of 409 patients with pathologically proven focal liver lesions who underwent contrast-enhanced ultrasound (CEUS) were recruited from our institution. Clinical liver cirrhosis, HBV/HCV infection and HCC-typical vascular pattern of the targeted lesion on CEUS were evaluated...
January 19, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29353161/automated-diagnosis-of-focal-liver-lesions-using-bidirectional-empirical-mode-decomposition-features
#2
U Rajendra Acharya, Joel En Wei Koh, Yuki Hagiwara, Jen Hong Tan, Arkadiusz Gertych, Anushya Vijayananthan, Nur Adura Yaakup, Basri Johan Jeet Abdullah, Mohd Kamil Bin Mohd Fabell, Chai Hong Yeong
Liver is the heaviest internal organ of the human body and performs many vital functions. Prolonged cirrhosis and fatty liver disease may lead to the formation of benign or malignant lesions in this organ, and an early and reliable evaluation of these conditions can improve treatment outcomes. Ultrasound imaging is a safe, non-invasive, and cost-effective way of diagnosing liver lesions. However, this technique has limited performance in determining the nature of the lesions. This study initiates a computer-aided diagnosis (CAD) system to aid radiologists in an objective and more reliable interpretation of ultrasound images of liver lesions...
January 3, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29352379/magnetic-resonance-with-diffusion-weighted-imaging-improves-assessment-of-focal-liver-lesions-in-patients-with-potentially-resectable-pancreatic-cancer-on-ct
#3
Sun Kyung Jeon, Jeong Min Lee, Ijin Joo, Dong Ho Lee, Su Joa Ahn, Hyunsik Woo, Myoung Seok Lee, Jin-Young Jang, Joon Koo Han
PURPOSE: To investigate added value of MRI to preoperative staging MDCT for evaluation of focal liver lesions (FLLs) in potentially resectable pancreatic ductal adenocarcinomas (PDACs). MATERIALS AND METHODS: In patients with potentially resectable PDACs after staging MDCT (n=167), characteristics of FLLs were scored as benign, indeterminate or metastases on an MDCT set and combined MDCT and MRI set by two readers, independently. Size of hepatic lesions was measured and detection rate of hepatic metastasis unsuspected by MDCT and diagnostic yield of MRI for FLLs were assessed...
January 19, 2018: European Radiology
https://www.readbyqxmd.com/read/29350068/primary-liver-cancers-part-1-histopathology-differential-diagnoses-and-risk-stratification
#4
Kun Jiang, Sameer Al-Diffhala, Barbara A Centeno
Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the 2 most common primary malignant liver tumors, with hepatocellular and bile ductular differentiation, respectively. This article reviews the key histopathological findings of these 2 primary liver cancers and includes a review of the role of ancillary testing for differential diagnosis, risk stratification according to the American Joint Committee on Cancer (AJCC) staging recommendation, and a review of precancerous lesions. A literature review was conducted to identify articles with information relevant to precancerous precursors, current histopathological classification, ancillary testing, and risk stratification of primary malignant liver tumors...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29349591/radical-resection-of-a-giant-retroperitoneal-calcifying-fibrous-tumor-combined-with-right-hepatectomy-and-reconstruction-of-the-inferior-vena-cava-and-bilateral-renal-veins
#5
Masaki Kimura, Hiroki Kato, Seishiro Sekino, Narihiro Ishida, Katsutoshi Murase, Katsuya Shimabukuro, Takafumi Sekino, Kiyoshi Doi, Masayuki Matsuo
BACKGROUND: We report a case of a giant retroperitoneal calcifying fibrous tumor (CFT) treated by radical tumor resection combined with right hepatectomy and reconstruction of the inferior vena cava (IVC) and bilateral renal veins. Only three case reports of CFT arising in the retroperitoneum have been reported until today. CASE PRESENTATION: In a 19-year-old female patient, computed tomography (CT) images showed a well-demarcated expansile lesion around the IVC accompanied by focal calcification, whereas the IVC that was circumferentially surrounded by the lesion was dilated due to the desmoplastic reaction...
January 18, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29334905/efficacy-comparison-of-multi-phase-ct-and-hepatotropic-contrast-enhanced-mri-in-the-differential-diagnosis-of-focal-nodular-hyperplasia-a-prospective-cohort-study
#6
Tomasz K Nowicki, Karolina Markiet, Ewa Izycka-Swieszewska, Katarzyna Dziadziuszko, Michal Studniarek, Edyta Szurowska
BACKGROUND: Different clinical behaviour influences the importance of differentiating focal nodular hyperplasia (FNH) from other focal liver lesions (FLLs). The aim of this study was to compare the efficacy of contrast-enhanced CT and MRI in the diagnosis of FNH. METHODS: 157 patients with equivocal FLLs detected in ultrasonography subsequently underwent multi-phase CT and MRI with the use of hepatotropic contrast agent (Gd-BOPTA) in a 1.5 T scanner. Examinations were evaluated by three independent readers...
January 15, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29301491/pancreatic-panniculitis-the-bright-side-of-the-moon-in-solid-cancer-patients
#7
Elena Guanziroli, Antonella Colombo, Antonella Coggi, Raffaele Gianotti, Angelo Valerio Marzano
BACKGROUND: Pancreatic panniculitis is a rare complication of pancreas disorders occurring in 0.3-3% of patients, most often accompanied by the pancreatic acinar carcinoma. It presents multiple, painful, deep, ill-defined, red-brown, migratory nodules and plaques of hard elastic consistency; often ulcerated and typically located on the lower proximal and distal extremities. The pathogenesis is not fully understood, but it is thought to result from lipolysis and fat necrosis with secondary tissue inflammation induced by pancreatic enzymes...
January 4, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29299367/contrast-enhanced-ultrasound-guided-biopsies-of-liver-lesions-not-visualized-on-standard-b-mode-ultrasound-preliminary-experience
#8
Sasan Partovi, Ziang Lu, Rivka Kessner, Alice Yu, Yasmine Ahmed, Indravadan J Patel, Dean A Nakamoto, Nami Azar
Background: To assess the technical success of contrast enhanced ultrasound (CEUS) guided biopsies of liver lesions poorly visualized on B-mode ultrasound. Methods: Patients were selected during the procedure based on the real-time clinical scenario of unsatisfactory B-mode ultrasound lesion visualization and all patients would have otherwise undergone CT guided liver lesion biopsy. A total of 26 patients underwent CEUS guided biopsy and were included in this retrospective analysis...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29277461/intra-cranial-granulomatous-disease-in-common-variable-immunodeficiency-case-series-and-review-of-the-literature
#9
REVIEW
Catherine E Najem, Jason Springer, Richard Prayson, Daniel A Culver, James Fernandez, Jinny Tavee, Rula A Hajj-Ali
BACKGROUND/PURPOSE: Common variable immunodeficiency (CVID) is typically characterized by hypogammaglobulinemia and often but not always recurrent infections. Paradoxically, 8-22% of patients with CVID develop granulomatous disease. Granulomata have been described in many organs including the lungs, skin, liver, spleen, kidneys, eyes, lymph nodes, and intestines. Data about central nervous system (CNS) involvement in CVID are extremely rare. We aim to describe a case series and include an extensive literature review of CNS involvement in CVID to understand the different features and patterns of the disease...
October 20, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29258813/novel-ultrasound-based-methods-to-assess-liver-disease-the-game-has-just-begun
#10
REVIEW
Annalisa Berzigotti, Giovanna Ferraioli, Simona Bota, Odd Helge Gilja, Christoph F Dietrich
In the last 10 years the availability of ultrasound elastography allowed to diagnose and stage liver fibrosis in a non-invasive way and changed the clinical practice of hepatology. Newer ultrasound-based techniques to evaluate properties of the liver tissue other than fibrosis are emerging and will lead to a more complete characterization of the full spectrum of diffuse and focal liver disease. Since these methods are currently undergoing validation and go beyond elastography for liver tissue evaluation, they were not included in the recent guidelines regarding elastography issued by the European Federation of Societies in Ultrasound in Medicine and Biology...
December 5, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29235486/free-breathing-3d-liver-perfusion-quantification-using-a-dual-input-two-compartment-model
#11
Satyam Ghodasara, Shivani Pahwa, Sara Dastmalchian, Vikas Gulani, Yong Chen
The purpose of this study is to test the feasibility of applying a dual-input two-compartment liver perfusion model to patients with different pathologies. A total of 7 healthy subjects and 11 patients with focal liver lesions, including 6 patients with metastatic adenocarcinoma and 5 with hepatocellular carcinoma (HCC), were examined. Liver perfusion values were measured from both focal liver lesions and cirrhotic tissues (from the 5 HCC patients). Compared to results from volunteer livers, significantly higher arterial fraction, fractional volume of the interstitial space, and lower permeability-surface area product were observed for metastatic lesions, and significantly higher arterial fraction and lower vascular transit time were observed for HCCs (P < 0...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29221964/inflammatory-hepatic-adenomas-characterization-with-hepatobiliary-mri-contrast-agents
#12
James F Glockner, Christine U Lee, Taofic Mounajjed
PURPOSE: To characterize the MRI appearance of inflammatory hepatic adenomas using hepatobiliary contrast agents. MATERIALS AND METHODS: MRI was performed using hepatobiliary contrast agents (3 with gadobenate dimeglumine and 24 with gadoxetic acid) in 27 patients with immunohistochemistry-confirmed diagnosis of inflammatory hepatic adenoma. The appearance of the lesions on T2 and diffusion-weighted images, pre-gadolinium T1-weighted images, dynamic post-gadolinium images, and hepatobiliary phase images was assessed...
December 5, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29220210/contrast-enhanced-ultrasound-of-the-liver-optimizing-technique-and-clinical-applications
#13
Emily H T Pang, Andy Chan, Stephen G Ho, Alison C Harris
OBJECTIVE: The purpose of this article is to review the general principles, technique, and clinical applications of contrast-enhanced ultrasound of the liver. CONCLUSION: Proper technique and optimization of contrast-enhanced ultrasound require a balance between maintaining the integrity of the microbubble contrast agent and preserving the ultrasound signal. Established and emerging applications in the liver include diagnosis of focal lesions, aiding ultrasound-guided intervention, monitoring of therapy, and aiding surgical management...
December 8, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29219625/utility-of-point-shear-wave-elastography-in-characterisation-of-focal-liver-lesions
#14
Maha Hasab-Allah, Rabab Mamoun Salama, Mohamed Saeed Marie, Ahmed Alsaeed Mohammed Mandur, Heba Omar
No abstract text is available yet for this article.
December 8, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29209117/application-of-superb-microvascular-imaging-in-focal-liver-lesions
#15
Meng-Na He, Ke Lv, Yu-Xin Jiang, Tian-An Jiang
AIM: To explore the ability of superb microvascular imaging (SMI) in differential diagnosis of focal liver lesions (FLLs) and to compare SMI morphology findings to those of color Doppler ultrasound and enhanced imaging. METHODS: Twenty-four patients with 31 FLLs were included in our study, with diagnoses of hemangioma (HE) (n = 17), hepatocellular carcinoma (HCC) (n = 5), metastatic lesions (n = 5), primary hepatic lymphoma (n = 1), focal nodular hyperplasia (FNH) (n = 2), and adenoma (n = 1)...
November 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29199055/bone-marrow-involvement-in-malignant-lymphoma-evaluation-of-quantitative-pet-and-mri-biomarkers
#16
Ulrika Asenbaum, Richard Nolz, Georgios Karanikas, Julia Furtner, Ramona Woitek, Ingrid Simonitsch-Klupp, Markus Raderer, Marius E Mayerhoefer
RATIONALE AND OBJECTIVES: This study aimed to determine the diagnostic utility of standardized uptake values (SUV) and apparent diffusion coefficients (ADC) for assessment of focal and diffuse bone marrow involvement in patients with malignant lymphoma. MATERIALS AND METHODS: Sixty treatment-naive patients (28 males; mean age 51.2 ± 16.7 years) with histologically proven lymphoma, who underwent fludeoxyglucose (18F) positron emission tomography-computed tomography ([F18]-FDG-PET/CT) and whole-body diffusion-weighted imaging (WB-DWI) within 7 days, and also routine bone marrow biopsy, were included in this institutional review board-approved, retrospective study...
November 30, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29197910/detection-and-characterization-of-small-superficially-located-focal-liver-lesions-by-contrast-enhanced-ultrasound-with-high-frequency-transducers
#17
Wen-Ping Wang, Yi Dong, Jiaying Cao, Feng Mao, Yadan Xu, Qin Si, Christoph F Dietrich
AIM: To evaluate the benefits of contrast-enhanced ultrasound (CEUS) with high frequency transducers in the detection and characterization of small superficially located focal liver lesions (FLLs). MATERIAL AND METHODS: From January 2015 to October 2016, 27 superficial FLLs detected by MRI were examined, first with the low frequency convex transducer (1-5 MHz) and afterwards with a high frequency transducer (7.5-12 MHz). High frequency dynamic CEUS was performed after a bolus injection of 2...
November 29, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/29193279/numerical-and-experimental-evaluation-of-high-intensity-focused-ultrasound-induced-lesions-in-liver-tissue-ex-vivo
#18
Samaneh Haddadi, Mohammad Taghi Ahmadian
OBJECTIVES: Recent advances in the field of acoustics and piezoelectric and ultrasound transducers have led to new approaches to the diagnosis and treatment of certain diseases. One method of treatment with ultrasonic waves is high-intensity focused ultrasound (HIFU) treatment, which is a thermal therapeutic method used to treat malignant tumors. Although a variety of treatment-planning strategies using ultrasonic waves have been investigated, little clinical success has been achieved...
November 30, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29189932/contrast-enhanced-us-for-characterization-of-focal-liver-lesions-a-comprehensive-meta-analysis
#19
Menglin Wu, Liang Li, Jiahui Wang, Yanyan Zhang, Qi Guo, Xue Li, Xuening Zhang
OBJECTIVES: This meta-analysis was performed to evaluate the accuracy of contrast-enhanced ultrasound (CEUS) in differentiating malignant from benign focal liver lesions (FLLs). METHODS: Cochrane Library, PubMed and Web of Science databases were systematically searched and checked for studies using CEUS in characterization of FLLs. Data necessary to construct 2×2 contingency tables were extracted from included studies. The QUADAS tool was utilized to assess the methodologic quality of the studies...
November 30, 2017: European Radiology
https://www.readbyqxmd.com/read/29167952/growth-of-focal-nodular-hyperplasia-is-not-a-reason-for-surgical-intervention-but-patients-should-be-referred-to-a-tertiary-referral-centre
#20
Mirelle E E Bröker, Anne J Klompenhouwer, Marcia P Gaspersz, Annick M E Alleleyn, Roy S Dwarkasing, Indra C Pieters, Robert A de Man, Jan N M IJzermans
BACKGROUND: When a liver lesion diagnosed as focal nodular hyperplasia (FNH) increases in size, it may cause doubt about the initial diagnosis. In many cases, additional investigations will follow to exclude hepatocellular adenoma or malignancy. This retrospective cohort study addresses the implications of growth of FNH for clinical management. METHODS: We included patients diagnosed with FNH based on ≥2 imaging modalities between 2002 and 2015. Characteristics of patients with growing FNH with sequential imaging in a 6-month interval were compared to non-growing FNH...
November 22, 2017: World Journal of Surgery
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