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https://www.readbyqxmd.com/read/29777523/application-of-cu-64-nodaga-psma-pet-in-prostate-cancer
#1
Sabina Sevcenco, Hans Christoph Klingler, Klaus Eredics, Alexander Friedl, Jenifer Schneeweiss, Peter Knoll, Thomas Kunit, Lukas Lusuardi, Siroos Mirzaei
INTRODUCTION: The high diagnostic potential of 64 Cu-PSMA PET-CT imaging was clinically investigated in prostate cancer patients with recurrent disease and in the primary staging of selected patients with advanced local disease. The aim of our study is to assess the uptake behavior in the clinical setting of 64Copper Prostate-Specific Membrane Antigen (64 Cu PSMA) Positron Emission Tomography/Computed Tomography (PET/CT) in prostate cancer. METHODS: A retrospective study was performed in 23 patients with intermediate, high risk and progressive disease at primary staging of prostate cancer...
May 17, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29769185/unusual-case-of-iron-overload-with-cancer-mimicking-abdominal-splenosis
#2
Giacomo Marchi, Giacomo Avesani, Alberto Zamò, Domenico Girelli
A 48-year-old man, former alcohol abuser and drug addicted, was referred to our tertiary referral centre for iron disorders because of marked hyperferritinaemia. His clinical history revealed chronic hepatitis C, ß-thalassaemia trait and post-traumatic splenectomy at age of 22. MRI-estimated liver iron content was markedly elevated, while first-line genetic test for haemochromatosis was negative. Alpha-fetoprotein was increased but liver ultrasonography did not reveal focal liver lesions. Multiphasic contrast-enhanced CT confirmed this result but showed two abdominal masses (diameter of 9 cm and 7 cm, respectively) among bowel loops, strongly suspicious for cancer...
May 16, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29764827/not-so-mass-effect-finding-of-a-remarkable-incidentaloma-in-a-teenager-with-neurofibromatosis
#3
Daniel John Keen, Hannah Norman-Bruce, Salah Mansy
A 13-year-old boy with neurofibromatosis type 1 presented to the emergency department twice in a fortnight with moderate intermittent abdominal pain, radiating to the back and associated with nausea and vomiting. He examined as a well child with a soft abdomen and minimal tenderness. A history of constipation was identified but he failed to respond to a trial of laxatives. Subsequent ultrasound abdomen demonstrated a large mass surrounding the porta hepatis. MRI further characterised a focal, non-aggressive lesion extending from his liver, encapsulating his pancreas, portal vessels and laterally displacing his spleen and left kidney...
May 14, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29749545/genome%C3%A2-wide-identification-of-long-noncoding-rnas-in-ccl4%C3%A2-induced-liver-fibrosis-via-rna-sequencing
#4
Zhenghua Gong, Jialin Tang, Tianxin Xiang, Jiayu Lin, Chaowen Deng, Yanzhong Peng, Jie Zheng, Guoxin Hu
Liver fibrosis occurs as a result of chronic liver lesions, which may subsequently develop into liver cirrhosis and hepatocellular carcinoma. The involvement of long noncoding RNAs (lncRNAs) in liver fibrosis is being increasingly recognized. However, the exact mechanisms and functions of the majority of lncRNAs are poorly characterized. In the present study, the hepatotoxic substance carbon tetrachloride (CCl4) was employed to induce liver fibrosis in an animal model and agenome‑wide identification of lncRNAs in fibrotic liver tissues compared with CCl4 untreated liver tissues was performed using RNA sequencing...
May 7, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29740826/can-point-shear-wave-elastography-differentiate-focal-nodular-hyperplasia-from-hepatocellular-adenoma
#5
Pavel Taimr, Anne Julia Klompenhouwer, Maarten G J Thomeer, Bettina E Hansen, Jan N M Ijzermans, Robert A de Man, Robert J de Knegt
PURPOSE: Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) are liver tumors that require different management. We assessed the potential of point shear wave elastography (pSWE) to differentiate FNH from HCA and the interobserver and intraobserver reliability of pSWE in the examination of these lesions and of native liver tissue (NLT). METHODS: The study included 88 patients (65 FNH, 23 HCA). pSWE was performed by two experienced liver sonographers (observers 1 [O1] and 2 [O2]) and acquired within the lesion of interest and NLT...
May 8, 2018: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29736844/correction-to-magnetic-resonance-with-diffusion-weighted-imaging-improves-assessment-of-focal-liver-lesions-in-patients-with-potentially-resectable-pancreatic-cancer-on-ct
#6
Sun Kyung Jeon, Jeong Min Lee, Ijin Joo, Dong Ho Lee, Su Joa Ahn, Hyunsik Woo, Myoung Seok Lee, Jin-Young Jang, Joon Koo Han
The original version of this article, published on 19 January 2018, unfortunately contained a mistake.
April 19, 2018: European Radiology
https://www.readbyqxmd.com/read/29725560/fatal-fulminant-hepatitis-from-rituximab-induced-hepatitis-b-reactivation-in-a-patient-with-follicular-lymphoma-a-case-report-and-a-brief-review-of-literature
#7
Zarak H Khan, Kamran Ilyas, Haider Ghazanfar, Hamza H Khan, Qulsoom Hussain, Sahla Hammad, Ahmed Munir, Rizwan Asim
The objective of our study was to recognize hepatitis B reactivation as a complication of rituximab chemotherapy and to realize the importance of screening for prior Hepatitis B virus (HBV) exposure in all patients with hematologic malignancies who will receive rituximab as part of their therapy. Rituximab is a monoclonal antibody targeting CD 20 receptors on the membrane of B cells. In this case report, we described a 79-year-old man who presented to our department with nausea, fatigue, and jaundice. Two months ago, he had received the last dose of the chemotherapy regimen containing rituximab for follicular B cell lymphoma...
March 2, 2018: Curēus
https://www.readbyqxmd.com/read/29718861/hepatic-metastases-from-primary-extremity-leiomyosarcomas-two-case-reports
#8
Naoki Mizoshiri, Toshiharu Shirai, Ryu Terauchi, Shinji Tsuchida, Yuki Mori, Yusei Katsuyama, Daichi Hayashi, Eiichi Konishi, Toshikazu Kubo
INTRODUCTION: Leiomyosarcoma is a highly malignant soft tissue sarcoma. Most leiomyosarcomas of the extremities metastasize initially to the lungs, with few metastasizing to the liver. Also, it is difficult to diagnose metastases to other regions of the lung during follow-up. CASE PRESENTATION: The first patient was a 51-year-old Japanese woman diagnosed with a leiomyosarcoma of the left distal femur. She underwent chemotherapy, followed by wide tumor excision and reconstruction using frozen autograft with total knee arthroplasty...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29714031/an-uncommon-presentation-of-alcoholic-liver-disease
#9
Jordi Gratacós-Ginès, Gerhard Jung, Alba Díaz, Xavier Forns
A 28-year-old man with previous medical history of chronic alcohol intake (>100g/day) was admitted into the hospital with jaundice and asthenia since the last 2 weeks. His alcohol consume had increased lately. Except for jaundice, physical examination was non relevant. Laboratory tests indicated: ASAT/ALAT 936/100 UI/L, Total bilirubin 26 mg/dl (predominantly direct), GGT 1021 UI/L, AP 327 UI/L, total cholesterol 335 mg/dl, triglycerides 515 mg/dl, platelet count 86x10^12/L, INR 1.74; white blood cell count and creatinine levels were normal...
April 30, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29704011/-ceus-diagnosis-of-benign-liver-lesions
#10
REVIEW
K Müller-Peltzer, J Rübenthaler, G Negrao de Figueiredo, D A Clevert
CLINICAL/METHODICAL ISSUE: Focal liver lesions are commonly seen during routine ultrasound examinations. STANDARD RADIOLOGICAL METHODS: With native ultrasound there are lesions that cannot be sufficiently characterized. In these cases additional imaging might be necessary. METHODICAL INNOVATIONS: With contrast-enhanced ultrasound (CEUS), focal liver lesions can be characterized with high diagnostic accuracy. After the ultrasound contrast agent has been injected into a peripheral vein, the examiner saves video loops of the arterial, portal venous and late contrast phases...
April 27, 2018: Der Radiologe
https://www.readbyqxmd.com/read/29675659/interobserver-and-intermodality-agreement-of-standardized-algorithms-for-non-invasive-diagnosis-of-hepatocellular-carcinoma-in-high-risk-patients-ceus-li-rads-versus-mri-li-rads
#11
Barbara Schellhaas, Matthias Hammon, Deike Strobel, Lukas Pfeifer, Christian Kielisch, Ruediger S Goertz, Alexander Cavallaro, Rolf Janka, Markus F Neurath, Michael Uder, Hannes Seuss
OBJECTIVES: We compared the interobserver agreement for the recently introduced contrast-enhanced ultrasound (CEUS)-based algorithm CEUS-LI-RADS (Liver Imaging Reporting and Data System) versus the well-established magnetic resonance imaging (MRI)-LI-RADS for non-invasive diagnosis of hepatocellular carcinoma (HCC) in high-risk patients. METHODS: Focal liver lesions in 50 high-risk patients (mean age 66.2 ± 11.8 years; 39 male) were assessed retrospectively with CEUS and MRI...
April 19, 2018: European Radiology
https://www.readbyqxmd.com/read/29671057/accurate-ivim-model-based-liver-lesion-characterisation-can-be-achieved-with-only-three-b-value-dwi
#12
P Mürtz, A M Sprinkart, M Reick, C C Pieper, A-H Schievelkamp, R König, H H Schild, W A Willinek, G M Kukuk
OBJECTIVE: The objective of this study was to evaluate a simplified intravoxel incoherent motion (IVIM) approach of diffusion-weighted imaging (DWI) with four b-values for liver lesion characterisation at 1.5 T. METHODS: DWI data from a respiratory-gated MRI sequence with b = 0, 50, 250, 800 s/mm2 were retrospectively analysed in 173 lesions and 40 healthy livers. The apparent diffusion coefficient ADC = ADC(0,800) and IVIM-based parameters D1 ' = ADC(50,800), D2 ' =ADC(250,800), f1 ', f2 ', D*', ADClow = ADC(0,50), and ADCdiff =ADClow -D2 ' were calculated voxel-wise without fitting procedures...
April 18, 2018: European Radiology
https://www.readbyqxmd.com/read/29671007/additional-value-of-contrast-enhanced-ultrasonography-for-fusion-guided-percutaneous-biopsies-of-focal-liver-lesions-prospective-feasibility-study
#13
Hyo-Jin Kang, Jung Hoon Kim, Sang Min Lee, Hyun Kyung Yang, Su Joa Ahn, Joon Koo Han
PURPOSE: To determine the value of CEUS for real-time, fusion-guided, percutaneous biopsies of focal liver lesions. MATERIALS AND METHODS: Institutional review board approval and written informed consents were obtained for this study. Forty patients with focal liver lesions identified on CT/MRI were prospectively enrolled. For biopsy planning, real-time fusion of CT/MRI with USG (USG-Fusion) was performed, and subsequently real-time CEUS was fused with CT/MRI (CEUS-Fusion)...
April 18, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29658347/contrast-enhanced-ultrasound-ceus-imaging-of-solid-benign-focal-liver-lesions
#14
Christoph F Dietrich, Claudio Tana, Cosmin Caraiani, Yi Dong
Ultrasound is well accepted worldwide for imaging of the liver. Absences of radiation exposure, low cost and large diffusion are some of the advantages that make this technique the first to be used in the assessment of focal liver lesions (FLL). Areas covered: Contrast enhanced ultrasound (CEUS) has been introduced more than twenty years ago, and its detection rate is comparable to that of contrast enhanced magnetic resonance imaging (CEMRI) and contrast enhanced computed tomography (CECT). In this narrative review, we discuss the main CEUS features of benign liver lesions and controversies in published results including the gold standard chosen and the quality and knowledge of the preferred techniques...
April 16, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29651715/can-tumor-coverage-evaluated-24-h-post-radiofrequency-ablation-predict-local-tumor-progression-of-liver-metastases
#15
Frederik Vandenbroucke, Jef Vandemeulebroucke, Nico Buls, Ruedi F Thoeni, Johan de Mey
PURPOSE: To assess the predictive value for local tumor progression (LTP) of geometrical tumor coverage using the contrast-enhanced (ce-)CT images acquired before and within 24 h after radiofrequency (RF) ablation. METHODS: Twenty patients (6 male and 14 female, median age 62 years) with 45 focal hypovascular liver metastases (16 colorectal carcinoma, 3 melanoma and 1 breast carcinoma) underwent RF ablation under CT-guidance and received a ce-PET/CT scan within 24 h post-procedure...
April 12, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29629518/atypical-presentation-of-pneumocystis-jirovecii-infection-in-hiv-infected-patients-three-different-manifestations
#16
Bongyoung Kim, Jieun Kim, Seung Sam Paik, Hyunjoo Pai
Advances in the treatment and prevention of Pneumocystis jirovecii infection (PJI) in human immunodeficiency virus (HIV) patients decreased incidence and mortality dramatically, however, it may be associated with an increased frequency of unusual manifestation such as cystic formation, pneumothorax, focal infiltration, nodular formation, or extrapulmonary lesions. We report three cases of PJI with atypical manifestations. Each case demonstrates different clinical features: multiple nodular pulmonary lesion (32-year-old man with abnormal chest X-ray finding), subpleural mass-like lesion (43-year-old man with left visual loss and right pleuritic chest pain), and extrapulmonary mass-like lesions in the liver, lymph nodes, and small bowel (39-year-old man with cough, sputum, and dyspnea)...
April 9, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29625858/m2-polarization-of-macrophages-by-oncostatin-m-in-hypoxic-tumor-microenvironment-is-mediated-by-mtorc2-and-promotes-tumor-growth-and-metastasis
#17
Richa Shrivastava, Mohammad Asif, Varsha Singh, Parul Dubey, Showkat Ahmad Malik, Mehraj-U-Din Lone, Brij Nath Tewari, Khemraj Singh Baghel, Subhashis Pal, Geet Kumar Nagar, Naibedya Chattopadhyay, Smrati Bhadauria
Oncostatin M (OSM), an inflammatory cytokine belonging to the interleukin-6 (IL-6) superfamily, plays a vital role in multitude of physiological and pathological processes. Its role in breast tumor progression and metastasis to distant organs is well documented. Recent reports implicate OSM in macrophage M2 polarization, a key pro-tumoral phenomenon. M2 polarization of macrophages is believed to promote tumor progression by potentiating metastasis and angiogenesis. In the current study, we delineated the mechanism underlying OSM induced macrophage M2 polarization...
April 3, 2018: Cytokine
https://www.readbyqxmd.com/read/29571616/laparoscopy-assisted-versus-open-and-pure-laparoscopic-approach-for-liver-resection-and-living-donor-hepatectomy-a-systematic-review-and-meta-analysis
#18
Fabricio F Coelho, Wanderley M Bernardo, Jaime A P Kruger, Vagner B Jeismann, Gilton M Fonseca, Rodrigo L Macacari, Danielle M Cesconetto, Luiz A C D'Albuquerque, Ivan Cecconello, Paulo Herman
BACKGROUND: Laparoscopy-assisted (hybrid) liver surgery is considered a minimally invasive technique, however there are doubts regarding loss of the benefits of laparoscopy due to the use of an auxiliary incision. The aim of this study was to compare perioperative results of hybrid vs. open and hybrid vs. pure laparoscopic approach to liver resection for focal lesions and living donation. METHODS: A systematic review was performed in Medline, EMBASE, Cochrane Library Central and LILACS databases...
March 20, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29571555/diffuse-liver-diseases-role-of-imaging
#19
Adele Taibbi, Dario Picone, Massimo Midiri, Ludovico La Grutta, Tommaso Vincenzo Bartolotta
Nowadays, the most common imaging techniques allow to study focal liver lesions with high diagnostic accuracy but a relatively recent emerging field of interest is represented by diffuse liver disease. They include a variegated series of storage and metabolic pathologies (ie, iron overload disorders and steatosis) requiring a precise diagnosis not always possible at imaging due to the overlapping of findings at conventional ultrasound, CT, or MR studies. In recent years, several imaging tecniques and specific softwares have been developed, especially for ultrasound and MR imaging, in order to identify different parameters useful in the noninvasive recognition and follow-up of these diffuse processes involving the liver...
April 2018: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/29570181/-benign-liver-tumours-current-diagnostics-and-therapeutic-modalities
#20
Gergely Nagy, Katalin Dezsõ, Gergely Kiss, Zsuzsanna Gerlei, Péter Nagy, László Kóbori
The most common benign liver tumours are haemangiomas, focal nodular hyperplasia and hepatocellular adenoma. We perform a review of the literature and show the current diagnostic and therapeutic modalities based on the EASL Clinical Practice Guideline. With the widespread use of ultrasound, the detection of liver lesions is increased. They are usually found in women of childbearing age with atypical abdominal pain or incidentally. Contrast-enhanced US, CT or MRI are usually necessary for differential diagnosis...
March 23, 2018: Magyar Onkologia
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