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https://www.readbyqxmd.com/read/28922441/evaluation-of-2d-shear-wave-elastography-for-characterisation-of-focal-liver-lesions
#1
Ludmila Gerber, Daniel Fitting, Kajana Srikantharajah, Nina Weiler, Georgia Kyriakidou, Joerg Bojunga, Falko Schulze, Dimitra Bon, Stefan Zeuzem, Mireen Friedrich-Rust
BACKGROUND AND AIM: This is a prospective study for evaluation of 2D-shear wave elastography (2D-SWE) for characterisation and differentiation of benign und malignant focal liver lesions (FLLs). METHODS: The patients referred to our ultrasound unit were prospectively included. B-mode ultrasound and 2D-SWE (Aixplorer® France) were performed for one FLL in each patient. Liver histology and/or contrast-enhanced imaging were used as a reference method. RESULTS: 140 patients with FLL were included...
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28921384/can-diffusion-weighted-imaging-distinguish-between-benign-and-malignant-pediatric-liver-tumors
#2
Pablo Caro-Domínguez, Abha A Gupta, Govind B Chavhan
BACKGROUND: There are limited data on utility of diffusion-weighted imaging (DWI) in the evaluation of pediatric liver lesions. OBJECTIVE: To determine whether qualitative and quantitative DWI can be used to differentiate benign and malignant pediatric liver lesions. MATERIALS AND METHODS: We retrospectively reviewed MRIs in children with focal liver lesions to qualitatively evaluate lesions noting diffusion restriction, T2 shine-through, increased diffusion, hypointensity on DWI and apparent diffusion coefficient (ADC) maps, and intermediate signal on both, and to measure ADC values...
September 18, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28905365/iron-storage-in-liver-bone-marrow-and-splenic-gaucheroma-reflects-residual-disease-in-type-1-gaucher-disease-patients-on-treatment
#3
Martine Regenboog, Anneloes E Bohte, Erik M Akkerman, Jaap Stoker, Carla E M Hollak
Gaucher disease (GD) is a lysosomal storage disorder characterized by the storage of glycosphingolipids in macrophages. Despite effective therapy, residual disease is present in varying degrees and may be associated with late complications, such as persistent bone or liver disease and increased cancer risk. Gaucher macrophages are capable of storing iron and locations of residual disease may thus be detectable with iron imaging. Forty type 1 GD (GD1) patients and 40 matched healthy controls were examined using a whole-body magnetic resonance imaging protocol consisting of standard sequences, allowing analysis of iron content per organ, expressed as R2* (Hz)...
September 14, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28902723/evaluation-of-transient-motion-during-gadoxetic-acid-enhanced-multiphasic-liver-magnetic-resonance-imaging-using-free-breathing-golden-angle-radial-sparse-parallel-magnetic-resonance-imaging
#4
Jeong Hee Yoon, Jeong Min Lee, Mi Hye Yu, Bo Yun Hur, Robert Grimm, Kai Tobias Block, Hersh Chandarana, Berthold Kiefer, Yohan Son
OBJECTIVES: The aims of this study were to observe the pattern of transient motion after gadoxetic acid administration including incidence, onset, and duration, and to evaluate the clinical feasibility of free-breathing gadoxetic acid-enhanced liver magnetic resonance imaging using golden-angle radial sparse parallel (GRASP) imaging with respiratory gating. MATERIALS AND METHODS: In this institutional review board-approved prospective study, 59 patients who provided informed consents were analyzed...
September 11, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28901621/objective-comparison-of-high-contrast-spatial-resolution-and-low-contrast-detectability-for-various-clinical-protocols-on-multiple-ct-scanners
#5
Damien Racine, Anaïs Viry, Fabio Becce, Sabine Schmidt, Alexandre Ba, François O Bochud, Sue Edyvean, Alexander Schegerer, Francis R Verdun
PURPOSE: We sought to compare objectively computed tomography (CT) scanner performance for three clinically relevant protocols using a task-based image quality assessment method in order to assess the potential for radiation dose reduction. METHODS: Four CT scanners released between 2003 and 2007 by different manufacturers were compared with four CT scanners released between 2012 and 2014 by the same manufacturers using ideal linear model observers (MO): prewhitening (PW) MO and channelized Hotelling (CHO) MO with Laguerre-Gauss channels for high-contrast spatial resolution and low-contrast detectability (LCD) performance, respectively...
September 2017: Medical Physics
https://www.readbyqxmd.com/read/28898188/contrast-enhanced-us-approach-to-the-diagnosis-of-focal-liver-masses
#6
David P Burrowes, Alexandra Medellin, Allison C Harris, Laurent Milot, Stephanie R Wilson
Focal liver lesions are commonly encountered and often demonstrate nonspecific findings at initial imaging. Although most incidentally discovered liver lesions are benign, their noninvasive diagnosis is necessary, especially if they are large or atypical. Imaging characterization of focal liver lesions and exclusion of malignancy are of prime importance, particularly in high-risk populations. Contrast agent-enhanced ultrasonography of liver lesions is both accurate and reproducible for evaluation of benign and malignant liver tumors...
September 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28894525/evaluation-of-cd44-and-cd133-as-markers-of-liver-cancer-stem-cells-in-egyptian-patients-with-hcv-induced-chronic-liver-diseases-versus-hepatocellular-carcinoma
#7
Mohammed Saeed Rozeik, Olfat Ali Hammam, Ali Ibrahim Ali, Mona Magdy, Heba Khalil, Amgad Anas, Ahmed Abdelaleem Abo El Hassan, Ali Abdel Rahim, Ahmed Ibrahim El-Shabasy
BACKGROUND: Cancer stem cells (CSCs) play a critical role in tumor development, progression, metastasis and recurrence. AIM: To evaluate hepatic expression of CD44 and CD133 in Egyptian patients with HCV-induced chronic liver diseases and hepatocellular carcinomas (HCCs), and to assess its correlation with inflammatory activity scores, stages of fibrosis (in chronic hepatitis with or without cirrhosis) and grades of HCC. METHODS: This prospective case-control study was conducted on eighty subjects who attended the Tropical Diseases Department, Al-Azhar University Hospital, and in collaboration with Theodor Bilharz Research Institute (2014-2016)...
July 2017: Electronic Physician
https://www.readbyqxmd.com/read/28878865/micrornas-and-clinical-implications-in-hepatocellular-carcinoma
#8
Amal Ahmed Mohamed, Zainab A Ali-Eldin, Tamer A Elbedewy, Magdy El-Serafy, Fatma A Ali-Eldin, Hossameldin AbdelAziz
AIM: To assess the role of some circulating miRNAs (miR-23a, miR-203, miR338, miR-34, and miR-16) as tumor markers for diagnosis of hepatocellular carcinoma (HCC). METHODS: One hundred and seventy-one subjects were enrolled, 57 patients with HCC, 57 patients with liver cirrhosis (LC) and 57 healthy subjects as control group. Severity of liver disease was assessed by Child Pugh score. Tumor staging was done using Okuda staging system. Quantification of Micro RNA (miR-23a, miR-203, miR338, miR-34, and miR-16) was performed...
August 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28874958/endoscopic-ultrasonography-emerging-applications-in-hepatology
#9
REVIEW
Joana Magalhães, Sara Monteiro, Sofia Xavier, Sílvia Leite, Francisca Dias de Castro, José Cotter
The inspection of the liver is a valuable part of the upper endoscopic ultrasonography (EUS) studies, regardless of the primary indication for the examination. The detailed images of the liver segments provided by EUS allows the use of this technique in the study of parenchymal liver disease and even in the diagnosis and classification of focal liver lesions. EUS has also emerged as an important tool in understanding the complex collateral circulation in patients with portal hypertension and their clinical and prognostic value...
August 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28871989/long-term-outcomes-of-phase-1-and-2-studies-of-sbrt-for-hepatic-colorectal-metastases
#10
Andrew McPartlin, Anand Swaminath, Ri Wang, Melania Pintilie, James Brierley, John Kim, Jolie Ringash, Rebecca Wong, Rob Dinniwell, Tim Craig, Laura A Dawson
PURPOSE: To report mature outcomes of prospective phase 1 and 2 studies of stereotactic body radiation therapy (SBRT) for the treatment of colorectal liver metastases (CLMs). METHODS AND MATERIALS: Patients with histologically confirmed CLMs unsuitable for resection or standard therapies were eligible for sequential phase 1 and 2 studies conducted from 2003 to 2012. RESULTS: Of 60 patients treated, 82% had received previous chemotherapy, 23% had undergone previous focal liver treatment, and 38% had extrahepatic disease at the time of SBRT...
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28866259/intravoxel-incoherent-motion-diffusion-weighted-imaging-evaluation-of-the-differentiation-of-solid-hepatic-lesions
#11
Ma Luo, Ling Zhang, Xin-Hua Jiang, Wei-Dong Zhang
PURPOSE: To evaluate whether intravoxel incoherent motion (IVIM)-related parameters could be used to differentiate malignant from benign focal liver lesions (FLLs) and to improve diagnostic efficiency. METHODS: Seventy-four patients with 75 lesions, including 51 malignant FLLs and 24 benign FLLs, underwent liver 3.0-T magnetic resonance imaging for routine examination sequences. IVIM diffusion-weighted imaging (DWI) with 11 b values (0-800s/mm(2)) was also acquired concurrently...
August 30, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28859746/oxalosis-in-a-patient-with-livedo-reticularis
#12
Meriam Triki, Meriem Ksentini, Rim Kallel, Emna Bahloul, Faiçal Jarraya, Abderrahmen Masmoudi, Tahya Boudawara
A 27-year-old man with terminal renal failure requiring peritoneal dialysis for the past 2 years was referred to the dermatologist for evaluation of red violaceous macular skin lesions consistent with livedo reticularis. These lesions had appeared suddenly on his legs (Figure 1). He had first experienced recurrent nephrolithiasis at the age of 14. Results from urine analysis and abdominal ultrasound revealed chronic kidney failure. Because the patient had a sister with similar findings, primary hyperoxaluria (PH) was suspected and genetic testing was performed in all members of his family...
2017: Skinmed
https://www.readbyqxmd.com/read/28856283/surgical-treatment-of-liver-tumors-own-experience-and-literature-review
#13
REVIEW
Aliaksandr Tarasik, Jerzy Jaroszewicz, Marcin Januszkiewicz
Despite advances, the treatment of focal liver lesions is still challenging. It requires the experience of a surgeon, improvement of existing and the development of new techniques. The aim of this article is to present a literature review and summarize our experience in liver surgery. Twenty-one patients with various liver tumors were treated in 2015 at the Department of Surgical Oncology of Bialystok Center for Oncology. Mostly patients were diagnosed with colorectal cancer liver metastases or hepatocellular carcinoma...
March 2017: Clin Exp Hepatol
https://www.readbyqxmd.com/read/28853804/-benign-focal-liver-lesions-a-clinical-radiological-and-pathological-review
#14
Karim Abdelrahman, Sabine Schmidt, Amedeo Sciarra, Christine Sempoux
Benign focal liver lesions are a heterogeneous group of tumors of different cellular origin. They might develop from mesenchymal cells, hepatocytes or cholangiocytes. They are more often detected due to the increasing number of imaging investigations and the excellent performance of the new ultrasound machines. The imaging findings have to be interpreted while bearing the patient's clinical context in mind. The aim of this review is to discuss the three most frequent benign focal hepatic lesions : hemangioma, focal nodular hyperplasia and hepatocellular adenoma...
August 30, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28851955/circulating-endothelial-cell-derived-extracellular-vesicles-mediate-the-acute-phase-response-and-sickness-behaviour-associated-with-cns-inflammation
#15
Yvonne Couch, Naveed Akbar, Jay Roodselaar, Matthew C Evans, Chris Gardiner, Ian Sargent, Ignacio A Romero, Adrian Bristow, Alastair M Buchan, Norman Haughey, Daniel C Anthony
Brain injury elicits a systemic acute-phase response (APR), which is responsible for co-ordinating the peripheral immunological response to injury. To date, the mechanisms responsible for signalling the presence of injury or disease to selectively activate responses in distant organs were unclear. Circulating endogenous extracellular vesicles (EVs) are increased after brain injury and have the potential to carry targeted injury signals around the body. Here, we examined the potential of EVs, isolated from rats after focal inflammatory brain lesions using IL-1β, to activate a systemic APR in recipient naïve rats, as well as the behavioural consequences of EV transfer...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28845490/point-shear-wave-speed-measurement-in-differentiating-benign-and-malignant-focal-liver-lesions
#16
Yi Dong, Wen-Ping Wang, Yadan Xu, Jiaying Cao, Feng Mao, Cristoph F Dietrich
AIM: To investigate the value of ElastPQ measurement for differential diagnosis of benign and malignant focal liver lesions (FLLs) by using histologic results as a reference standard. MATERIAL AND METHODS: A total of 154 patients were included. ElastPQ measurement was performed for each lesion in which the shear wave speed (SWS) was measured. The difference in SWS and SWS ratio of FLL to surrounding liver were evaluated, and the cut off value was investigated...
June 26, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/28845489/is-contrast-enhanced-ultrasonography-a-useful-tool-in-a-beginner-s-hand-how-much-can-a-computer-assisted-diagnosis-prototype-help-in-characterizing-the-malignancy-of-focal-liver-lesions
#17
Tudor Voicu Moga, Alina Popescu, Ioan Sporea, Mirela Danila, Ciprian David, Vasile Gui, Nicoleta Iacob, Gratian Miclaus, Roxana Sirli
AIM: Contrast enhanced ultrasound (CEUS) improved the characterization of focal liver lesions (FLLs), but is an operatordependent method. The goal of this paper was to test a computer assisted diagnosis (CAD) prototype and to see its benefit in assisting a beginner in the evaluation of FLLs. MATERIAL AND METHOD: Our cohort included 97 good quality CEUS videos[34% hepatocellular carcinomas (HCC), 12.3% hypervascular metastases (HiperM), 11.3% hypovascular metastases (HipoM), 24...
August 23, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/28830058/contrast-enhanced-ultrasonography-of-the-liver-using-sonovue
#18
Giovanna Ferraioli, Maria Franca Meloni
This review focuses on the use of contrast-enhanced ultrasonography (CEUS) with SonoVue Epub ahead of print (Bracco Imaging) for the diagnosis of focal liver lesions (FLLs), guidance during ablative treatment, and follow-up of liver tumors. Multicenter trials have shown that the performance of CEUS for the characterization of FLLs is similar to that of contrast-enhanced computed tomography or contrast-enhanced magnetic resonance imaging. CEUS with SonoVue has been effectively used for guiding the percutaneous treatment of malignant liver tumors that are invisible or poorly visualized in traditional gray-scale ultrasonography...
July 12, 2017: Ultrasonography
https://www.readbyqxmd.com/read/28813771/hepatic-adenoma-a-case-report
#19
Hasan H Turaihi, Thavam C Thambi-Pillai
Although liver lesions in the young population are relatively rare, clinicians can benefit from being familiar with a subset of common benign liver lesions which include hepatic adenoma, hepatic hemangioma, and focal nodular hyperplasia. This a case report of a 25-year-old Jehovah's Witness female on chronic oral contraception for polycystic ovarian syndrome who presented with progressive right upper quadrant abdominal pain. Ultrasound and MRI findings were consistent with hepatic adenoma. A description of her clinical work up followed by a brief description of the surgical intervention is discussed...
March 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28809681/a-prototype-therapy-system-for-transcutaneous-application-of-boiling-histotripsy
#20
Adam D Maxwell, Petr V Yuldashev, Wayne Kreider, Tatiana D Khokhlova, George R Schade, Timothy L Hall, Oleg A Sapozhnikov, Michael R Bailey, Vera A Khokhlova
Boiling histotripsy is a method of focused ultrasound surgery that noninvasively applies millisecond-length pulses with high-amplitude shock fronts to generate liquefied lesions in tissue. Such a technique requires unique outputs compared to a focused ultrasound thermal therapy apparatus, particularly to achieve high in situ pressure levels through intervening tissue. This article describes the design and characterization of a system capable of producing the necessary pressure to transcutaneously administer boiling histotripsy therapy through clinically relevant overlying tissue paths using pulses with duration up to 10 ms...
August 14, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
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