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https://www.readbyqxmd.com/read/29136233/a-simple-method-for-calibrating-pixel-values-of-the-ct-localizer-radiograph-for-calculating-water-equivalent-diameter-and-size-specific-dose-estimate
#1
Choirul Anam, Toshioh Fujibuchi, Takatoshi Toyoda, Naoki Sato, Freddy Haryanto, Rena Widita, Idam Arif, Geoff Dougherty
The purpose of this study is to establish the relationship between the pixel value (I) of the CT localizer radiograph and water-equivalent thickness (tw) in a straightforward procedure. We used a body CTDI phantom, which was scanned in the AP and LAT projections. After transformation from the pixel values of the images to tw, water-equivalent diameter (Dw) and size-specific dose estimate were calculated on an anthropomorphic phantom and 30 patients retrospectively. We found a linear correlation between I and tw, with R2 ≥ 0...
November 9, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29132393/interferon-%C3%AE-inducible-protein-16-ifi16-is-required-for-the-maintenance-of-epstein-barr-virus-latency
#2
Gina Pisano, Arunava Roy, Mairaj Ahmed Ansari, Binod Kumar, Leela Chikoti, Bala Chandran
BACKGROUND: Epstein-Barr virus (EBV) exhibits both lytic and latent (Lat. I, II, and III) phases in an infected individual. It's during the latent phase of EBV that all EBV-associated cancers, including Burkitt's lymphoma, nasopharyngeal carcinoma and lymphoproliferative disease arise. Interferon-γ-inducible protein 16 (IFI16) is a well-established innate immune sensor and viral transcriptional regulator involved in response to invading DNA viruses. During latency, IFI16 remains in the nucleus, in part bound to the EBV genome; however, neither its role in EBV lytic cycle or latency has been established...
November 13, 2017: Virology Journal
https://www.readbyqxmd.com/read/29116649/wwc-proteins-regulate-hepatic-cell-differentiation-and-tumorigenesis-via-the-hippo-signaling-pathway
#3
Anke Hermann, Dirk Oliver Wennmann, Sascha Gromnitza, Maria Edeling, Veerle Van Marck, Marius Sudol, Liliana Schaefer, Kerstin Duning, Thomas Weide, Hermann Pavenstädt, Joachim Kremerskothen
The Hippo pathway regulates cell differentiation, proliferation and apoptosis. Upon activation, it inhibits the import of the transcriptional co-activator YAP into the nucleus, thus suppressing transcription of pro-proliferative genes. Hence, dynamic and precise control of the Hippo pathway is crucial for organ size control and the prevention of tumor formation. Hippo signaling is controlled by a growing number of upstream regulators - including WWC proteins - which trigger a serine/threonine kinase pathway...
November 8, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29106546/clinical-validation-of-automatic-local-activation-time-annotation-during-focal-premature-ventricular-complex-ablation-procedures
#4
Juan Acosta, David Soto-Iglesias, Juan Fernández-Armenta, Manuel Frutos-López, Beatriz Jáuregui, Eduardo Arana-Rueda, Marcos Fernández, Diego Penela, Alejandro Alcaine, Lucas Cano, Alonso Pedrote, Antonio Berruezo
Aims: Current navigation systems incorporate algorithms for automatic identification of local activation time (LAT). However, data about their utility and accuracy in premature ventricular complex (PVC) ablation procedures are scarce. This study analyses the accuracy of an algorithmic method based on automatic annotation of the maximal negative slope of the unipolar electrogram within the window demarcated by the bipolar electrogram compared with conventional manual annotation during PVC ablation procedures...
November 2, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29104896/non-radioactive-lats-in-vitro-kinase-assay
#5
Audrey W Hong, Kun-Liang Guan
This protocol describes a method to directly measure LATS activity by an in vitro kinase assay using YAP as a substrate.
July 20, 2017: Bio-protocol
https://www.readbyqxmd.com/read/29097690/ruling-out-dark-matter-interpretation-of-the-galactic-gev-excess-by-gamma-ray-data-of-galaxy-clusters
#6
Man Ho Chan, Chung Hei Leung
Recently, some very tight constraints of annihilating dark matter have been obtained from gamma-ray data of the Milky Way and Milky Way dwarf spheroidal satellite galaxies. In this article, we report that there are two excellent galaxy clusters (A2877 and Fornax) which can provide interesting constraints for annihilating dark matter. The lower limits of the dark matter mass for the thermal relic annihilation cross section are 25 GeV, 6 GeV, 130 GeV and 100 GeV respectively for the e (+) e (-), μ (+) μ (-), τ (+) τ (-) and [Formula: see text] channels...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29094246/multi-approach-analysis-of-the-diversity-in-colletotrichum-cliviae-sensu-lato
#7
C Douanla-Meli, J-G Unger, E Langer
Colletotrichum cliviae is a fungal species reported both as pathogen and endophyte with broad geographical distribution. Some purported isolates of this species have been assigned to different taxa, including Colletotrichum aracearum, Colletotrichum orchidearum and Colletotrichum. sichuanensis, for which a preliminary analysis of extensive multilocus (ACT, GAPDH, ITS, TUB2) data in this study revealed high sequence similarity with C. cliviae. We further reassessed the species delineation by using the coalescent method of the generalized mixed Yule-coalescent (GMYC) and Poisson Tree Processes (PTP)...
November 1, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29083489/ottia-meiospora-ottiaceae-rhodophyta-a-new-genus-and-family-endophytic-within-the-thallus-of-nothocladus-batrachospermales-rhodophyta
#8
Timothy J Entwisle, Joshua R Evans, Morgan L Vis, Gary W Saunders
A new genus, Ottia, and family, Ottiaceae, are proposed within the Acrochaetiales to accommodate the uniseriate red algal endophyte of batrachspermalean taxa previously named Balbiania meiospora. Prior to this study Balbiania investiens was transferred to its own family and order (Balbianiales) based on comparative DNA sequence data and a distinctive reproductive morphology. However, the second species described in this genus, Balbiania meiospora, continued to be treated as a species of Audouinella (A. meiospora) pending further investigation...
October 30, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/29082287/flow-cytometric-analysis-of-hiv-1-transcriptional-activity-in-response-to-shrna-knockdown-in-a2-and-a72-j-lat-cell-lines
#9
Daniela Boehm, Melanie Ott
The main obstacle to eradicating HIV-1 from patients is post-integration latency (Finzi et al., 1999). Antiretroviral treatments target only actively replicating virus, while latent infections that have low or no transcriptional activity remain untreated (Sedaghat et al., 2007). To eliminate viral reservoirs, one strategy focuses on reversing HIV-1 latency via 'shock and kill' (Deeks, 2012). The basis of this strategy is to overcome the molecular mechanisms of HIV-1 latency by therapeutically inducing viral gene and protein expression under antiretroviral therapy and to cause selective cell death via the lytic properties of the virus, or the immune system now recognizing the infected cells...
June 5, 2017: Bio-protocol
https://www.readbyqxmd.com/read/29063833/sav1-promotes-hippo-kinase-activation-through-antagonizing-the-pp2a-phosphatase-stripak
#10
Sung Jun Bae, Lisheng Ni, Adam Osinski, Diana R Tomchick, Chad A Brautigam, Xuelian Luo
The Hippo pathway controls tissue growth and homeostasis through a central MST-LATS kinase cascade. The scaffold protein SAV1 promotes the activation of this kinase cascade, but the molecular mechanisms remain unknown. Here, we discover SAV1-mediated inhibition of the PP2A complex STRIPAK(SLMAP) as a key mechanism of MST1/2 activation. SLMAP binding to autophosphorylated MST2 linker recruits STRIPAK and promotes PP2A-mediated dephosphorylation of MST2 at the activation loop. Our structural and biochemical studies reveal that SAV1 and MST2 heterodimerize through their SARAH domains...
October 24, 2017: ELife
https://www.readbyqxmd.com/read/29062310/analysis-of-the-protective-immunity-induced-by-herpes-simplex-virus-1-strain-m3-with-an-attenuated-phenotype-due-to-mutations-in-the-viral-ul7-ul41-and-lat-genes
#11
Xingli Xu, Shengtao Fan, Xi Wang, Yunguang Hu, Min Feng, Lichun Wang, Ying Zhang, Yun Liao, Xiaolong Zhang, Qihan Li
Herpes simplex virus 1 (HSV1) is an important pathogen with a worldwide epidemic trend that affects populations of various ages. It has a high morbidity, particularly in juveniles, but a successful HSV1 vaccine is not currently available. Thus, our study systematically observed the immune responses induced in mice immunized with the attenuated HSV1 M3 mutant strain, which has mutations in the genes encoding the UL7 and Vhs tegument proteins and the latency-associated transcript. The immunity induced by the M3 mutant strain can control acute viral infection during HSV1 wild-type strain infection...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29062049/the-role-of-grain-boundary-scattering-in-reducing-the-thermal-conductivity-of-polycrystalline-xnisn-x%C3%A2-%C3%A2-hf-zr-ti-half-heusler-alloys
#12
Matthias Schrade, Kristian Berland, Simen N H Eliassen, Matylda N Guzik, Cristina Echevarria-Bonet, Magnus H Sørby, Petra Jenuš, Bjørn C Hauback, Raluca Tofan, Anette E Gunnæs, Clas Persson, Ole M Løvvik, Terje G Finstad
Thermoelectric application of half-Heusler compounds suffers from their fairly high thermal conductivities. Insight into how effective various scattering mechanisms are in reducing the thermal conductivity of fabricated XNiSn compounds (X = Hf, Zr, Ti, and mixtures thereof) is therefore crucial. Here, we show that such insight can be obtained through a concerted theory-experiment comparison of how the lattice thermal conductivity κ Lat(T) depends on temperature and crystallite size. Comparing theory and experiment for a range of Hf0...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29059485/clinical-assessment-and-comparison-of-annotation-algorithms-in-high-density-mapping-of-regular-atrial-tachycardias
#13
Jan De Pooter, Milad El Haddad, Michael Wolf, Thomas Phlips, Frederic van Heuverswyn, Liesbeth Timmers, René Tavernier, Sebastien Knecht, Yves Vandekerckhove, Mattias Duytschaever
BACKGROUND: High-density automated mapping of regular atrial tachycardias (AT) requires accurate assessment of local activation times (LAT). OBJECTIVE: To evaluate high density mapping of ATs and compare the accuracy of different automated LAT annotation algorithms. METHODS: Fifteen patients underwent AT ablation guided by the automated ConfiDENSEۛ high-density mapping module (Carto 3 v4) allowing manual reannotation (edited maps). For each AT, unedited automated maps were re-constructed offline by three algorithms: maximum unipolar slope (LATSlope ), bipolar peak (LATPeak ) and a new hybrid annotation algorithm (LATHybrid )...
October 23, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29058874/multibranched-gold-nanoparticles-with-intrinsic-lat-1-targeting-capabilities-for-selective-photothermal-therapy-of-breast-cancer
#14
Zhan Yuin Ong, Shu Chen, Elham Nabavi, Anna Regoutz, David J Payne, Daniel S Elson, David T Dexter, Iain E Dunlop, Alexandra E Porter
Because of the critical role of the large neutral amino acid transporter-1 (LAT-1) in promoting tumor growth and proliferation, it is fast emerging as a highly attractive biomarker for the imaging and treatment of human malignancies, including breast cancer. While multibranched gold nanoparticles (AuNPs) have emerged as a promising modality in the photothermal therapy (PTT) of cancers, some of the key challenges limiting their clinical translation lie in the need to develop reproducible and cost-effective synthetic methods as well as the selective accumulation of sufficient AuNPs at tumor sites...
November 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29052597/syk-expression-in-monomorphic-epitheliotropic-intestinal-t-cell-lymphoma
#15
Grit Mutzbauer, Katja Maurus, Clara Buszello, Jordan Pischimarov, Sabine Roth, Andreas Rosenwald, Andreas Chott, Eva Geissinger
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), formerly known as type II enteropathy associated T-cell lymphoma (type II EATL), is a rare, aggressive primary intestinal T-cell lymphoma with a poor prognosis and an incompletely understood pathogenesis. We collected 40 cases of MEITL and 27 cases of EATL, formerly known as type I EATL, and comparatively investigated the T-cell receptor (TCR) itself and associated signaling molecules using immunohistochemistry, amplicon deep sequencing and bisulfite pyrosequencing...
October 20, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29045874/dynamic-scaling-analysis-of-molecular-motion-within-the-lat-grb2-sos-protein-network-on%C3%A2-membranes
#16
William Y C Huang, Han-Kuei Chiang, Jay T Groves
Biochemical signaling pathways often involve proteins with multiple, modular interaction domains. Signaling activates binding sites, such as by tyrosine phosphorylation, which enables protein recruitment and growth of networked protein assemblies. Although widely observed, the physical properties of the assemblies, as well as the mechanisms by which they function, remain largely unknown. Here we examine molecular mobility within LAT:Grb2:SOS assemblies on supported membranes by single-molecule tracking. Trajectory analysis reveals a discrete temporal transition to subdiffusive motion below a characteristic timescale, indicating that the LAT:Grb2:SOS assembly has the dynamical structure of a loosely entangled polymer...
October 17, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29043465/comparison-of-strain-imaging-techniques-in-crt-candidates-cmr-tagging-cmr-feature-tracking-and-speckle-tracking-echocardiography
#17
Wouter M van Everdingen, Alwin Zweerink, Robin Nijveldt, Odette A E Salden, Mathias Meine, Alexander H Maass, Kevin Vernooy, Frederik J De Lange, Albert C van Rossum, Pierre Croisille, Patrick Clarysse, Bastiaan Geelhoed, Michiel Rienstra, Isabelle C Van Gelder, Marc A Vos, Cornelis P Allaart, Maarten J Cramer
Parameters using myocardial strain analysis may predict response to cardiac resynchronization therapy (CRT). As the agreement between currently available strain imaging modalities is unknown, three different modalities were compared. Twenty-seven CRT-candidates, prospectively included in the MARC study, underwent cardiac magnetic resonance (CMR) imaging and echocardiographic examination. Left ventricular (LV) circumferential strain was analysed with CMR tagging (CMR-TAG), CMR feature tracking (CMR-FT), and speckle tracking echocardiography (STE)...
October 17, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29040707/effective-radiation-dose-in-the-wrist-resulting-from-a-radiographic-device-two-cbct-devices-and-one-msct-device-a-comparative-study
#18
Juha Koivisto, Maureen van Eijnatten, Timo Kiljunen, Xie-Qi Shi, Jan Wolff
The objective of the present study was to assess and compare the effective doses in the wrist region resulting from conventional radiography device, multislice computed tomography (MSCT) device and two cone beam computed tomography (CBCT) devices using MOSFET dosemeters and a custom made anthropomorphic RANDO phantom according to the ICRP 103 recommendation. The effective dose for the conventional radiography was 1.0 μSv. The effective doses for the NewTom 5 G CBCT ranged between 0.7 μSv and 1.6 μSv, for the Planmed Verity CBCT 2...
October 13, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29031436/detection-of-concentric-left-ventricular-wall-hypertrophy-by-contrast-enhanced-non-electrocardiogram-gated-chest-computed-tomography
#19
Andrew Yen, Jennifer Feneis, Luis R Castellanos
BACKGROUND: No established measure of concentric left ventricular wall hypertrophy (cLVH) on routine computed tomography (CT) of the adult chest currently exists. The objective of this study was to identify and test linear measures for the detection of cLVH using transthoracic echocardiography (TTE) as the reference standard. METHODS: Contrast-enhanced non-electrocardiogram-gated chest CTs acquired within two weeks of TTE were retrospectively evaluated. Two radiologists independently made trans-axial measurements in the proximal half of the left ventricle at its approximate widest internal diameter: maximum septal thickness (sept), maximum lateral wall thickness (lat), and inner (Id) and outer (Od) wall-wall diameters at the level of greatest combined myocardial thickness...
September 23, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29030653/lateral-unicompartmental-knee-replacement-a-systematic-review-of-reasons-for-failure
#20
REVIEW
Lukas Ernstbrunner, Mohamed A Imam, Octavian Andronic, Tabea Perz, Karl Wieser, Sandro F Fucentese
PURPOSE: Currently, individual studies lack the power to successively illustrate different failure modes; therefore, we undertook a systematic review to examine lateral unicompartmental knee replacement (lat UKR) failure modes. Furthermore, we compared early with midterm and late failures and fixed-bearing with mobile-bearing implants. METHODS: A search using the databases of PubMed, EMBASE, Cochrane, and annual registries was performed to search for failed lat UKRs...
October 13, 2017: International Orthopaedics
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