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Adham Elsayed, Sebastian Wille, Majed Al-Akhali, Matthias Kern
STATEMENT OF PROBLEM: The whitish color of zirconia (ZrO2) abutments offers favorable esthetics compared with the grayish color of titanium (Ti) abutments. Nonetheless, ZrO2 has greater opacity, making it difficult to achieve natural tooth color. Therefore, lithium disilicate (LaT) abutments have been suggested to replace metal abutments. PURPOSE: The purpose of this in vitro study was to evaluate the fracture strength and failure mode of single-tooth implant restorations using ZrO2 and LaT abutments, and to compare them with titanium (Ti) abutments...
October 18, 2016: Journal of Prosthetic Dentistry
H Abdalla, A Abramowski, F Aharonian, F Ait Benkhali, A G Akhperjanian, T Andersson, E O Angüner, M Arrieta, P Aubert, M Backes, A Balzer, M Barnard, Y Becherini, J Becker Tjus, D Berge, S Bernhard, K Bernlöhr, E Birsin, R Blackwell, M Böttcher, C Boisson, J Bolmont, P Bordas, J Bregeon, F Brun, P Brun, M Bryan, T Bulik, M Capasso, J Carr, S Casanova, N Chakraborty, R Chalme-Calvet, R C G Chaves, A Chen, J Chevalier, M Chrétien, S Colafrancesco, G Cologna, B Condon, J Conrad, C Couturier, Y Cui, I D Davids, B Degrange, C Deil, J Devin, P deWilt, A Djannati-Ataï, W Domainko, A Donath, L O'C Drury, G Dubus, K Dutson, J Dyks, M Dyrda, T Edwards, K Egberts, P Eger, J-P Ernenwein, S Eschbach, C Farnier, S Fegan, M V Fernandes, A Fiasson, G Fontaine, A Förster, S Funk, M Füßling, S Gabici, M Gajdus, Y A Gallant, T Garrigoux, G Giavitto, B Giebels, J F Glicenstein, D Gottschall, A Goyal, M-H Grondin, M Grudzińska, D Hadasch, J Hahn, J Hawkes, G Heinzelmann, G Henri, G Hermann, O Hervet, A Hillert, J A Hinton, W Hofmann, C Hoischen, M Holler, D Horns, A Ivascenko, A Jacholkowska, M Jamrozy, M Janiak, D Jankowsky, F Jankowsky, M Jingo, T Jogler, L Jouvin, I Jung-Richardt, M A Kastendieck, K Katarzyński, U Katz, D Kerszberg, B Khélifi, M Kieffer, J King, S Klepser, D Klochkov, W Kluźniak, D Kolitzus, Nu Komin, K Kosack, S Krakau, M Kraus, F Krayzel, P P Krüger, H Laffon, G Lamanna, J Lau, J-P Lees, J Lefaucheur, V Lefranc, A Lemière, M Lemoine-Goumard, J-P Lenain, E Leser, R Liu, T Lohse, M Lorentz, I Lypova, V Marandon, A Marcowith, C Mariaud, R Marx, G Maurin, N Maxted, M Mayer, P J Meintjes, M Meyer, A M W Mitchell, R Moderski, M Mohamed, K Morå, E Moulin, T Murach, M de Naurois, F Niederwanger, J Niemiec, L Oakes, P O'Brien, H Odaka, S Ohm, M Ostrowski, S Öttl, I Oya, M Padovani, M Panter, R D Parsons, M Paz Arribas, N W Pekeur, G Pelletier, C Perennes, P-O Petrucci, B Peyaud, S Pita, H Poon, D Prokhorov, H Prokoph, G Pühlhofer, M Punch, A Quirrenbach, S Raab, A Reimer, O Reimer, M Renaud, R de Los Reyes, F Rieger, C Romoli, S Rosier-Lees, G Rowell, B Rudak, C B Rulten, V Sahakian, D Salek, D A Sanchez, A Santangelo, M Sasaki, R Schlickeiser, F Schüssler, A Schulz, U Schwanke, S Schwemmer, M Settimo, A S Seyffert, N Shafi, I Shilon, R Simoni, H Sol, F Spanier, G Spengler, F Spies, Ł Stawarz, R Steenkamp, C Stegmann, F Stinzing, K Stycz, I Sushch, J-P Tavernet, T Tavernier, A M Taylor, R Terrier, L Tibaldo, M Tluczykont, C Trichard, R Tuffs, J van der Walt, C van Eldik, B van Soelen, G Vasileiadis, J Veh, C Venter, A Viana, P Vincent, J Vink, F Voisin, H J Völk, T Vuillaume, Z Wadiasingh, S J Wagner, P Wagner, R M Wagner, R White, A Wierzcholska, P Willmann, A Wörnlein, D Wouters, R Yang, V Zabalza, D Zaborov, M Zacharias, A A Zdziarski, A Zech, F Zefi, A Ziegler, N Żywucka
: A search for dark matter linelike signals iss performed in the vicinity of the Galactic Center by the H.E.S.S. experiment on observational data taken in 2014. An unbinned likelihood analysis iss developed to improve the sensitivity to linelike signals. The upgraded analysis along with newer data extend the energy coverage of the previous measurement down to 100 GeV. The 18 h of data collected with the H.E.S.S. array allow one to rule out at 95% C.L. the presence of a 130 GeV line (at l=-1...
October 7, 2016: Physical Review Letters
Michael S Zhang, Jon C D Houtman
Glycerol monolaurate (GML) is a monoglyceride with well characterized anti-microbial properties. Because of these properties, GML is widely used in food, cosmetics, and personal care products and currently being tested as a therapeutic for menstrual associated toxic shock syndrome, superficial wound infections, and HIV transmission. Recently, we have described that GML potently suppresses select T cell receptor (TCR)-induced signaling events, leading to reduced human T cell effector functions. However, how soluble host factors present in the blood and at sites of infection affect GML-mediated human T cell suppression is unknown...
2016: PloS One
Bachir Latli, Michael Stiasni, Matt Hrapchak, Zhibin Li, Nelu Grinberg, Heewon Lee, Carl A Busacca, Chris H Senanayake
Hyosine butyl bromide, the active ingredient in Buscopan, is an anticholinergic and antimuscarinic drug used to treat pain and discomfort caused by abdominal cramps. A straightforward synthesis of carbon-14- and deuterium-labeled Buscopan was developed using scopolamine, n-butyl-1-(14) C bromide, and n-butyl-(2) H9 bromide, respectively. In a second carbon-14 synthesis, the radioactive carbon was incorporated in the tropic acid moiety to follow its metabolism. Herein, we describe the detailed preparations of carbon-14- and deuterium-labeled Buscopan...
October 17, 2016: Journal of Labelled Compounds & Radiopharmaceuticals
Wolfgang Kuchinke, Christian Krauth, René Bergmann, Töresin Karakoyun, Astrid Woollard, Irene Schluender, Benjamin Braasch, Martin Eckert, Christian Ohmann
BACKGROUND: In an unprecedented rate data in the life sciences is generated and stored in many different databases. An ever increasing part of this data is human health data and therefore falls under data protected by legal regulations. As part of the BioMedBridges project, which created infrastructures that connect more than 10 ESFRI research infrastructures (RI), the legal and ethical prerequisites of data sharing were examined employing a novel and pragmatic approach. METHODS: We employed concepts from computer science to create legal requirement clusters that enable legal interoperability between databases for the areas of data protection, data security, Intellectual Property (IP) and security of biosample data...
July 7, 2016: BMC Medical Informatics and Decision Making
Damien Ertz, Bettina Heuchert, Uwe Braun, Colin E Freebury, Ralph S Common, Paul Diederich
Taeniolella is a genus of asexual ascomycetes with saprophytic, endophytic, and lichenicolous life styles. A phylogeny of representative species is presented, with a focus on lichenicolous taxa. We obtained mtSSU and nuLSU sequence data from culture isolates of Taeniolella and from freshly collected specimens of other taxa. Taeniolella is recovered as strongly polyphyletic. The type species, Taeniolella exilis, is placed in Kirschsteiniotheliaceae within Dothideomycetes. Other saprophytic/endophytic Taeniolella species previously assigned to Sordariomycetes based on sequences were found to represent either contaminants or species that cannot be assigned to Taeniolella for morphological reasons...
November 2016: Fungal Biology
Perrine Rasschaert, Thomas Figueroa, Ginette Dambrine, Denis Rasschaert, Sylvie Laurent
Interplay between alternative splicing and the Microprocessor may have differential effects on the expression of intronic miRNAs organised into clusters. We used a viral model - the LAT long non-coding RNA (LAT lncRNA) of Marek's disease oncogenic herpesvirus (MDV-1), which has the mdv1-miR-M8-M6-M7-M10 cluster embedded in its first intron - to assess the impact of splicing modifications on the biogenesis of each of the miRNAs from the cluster. Drosha silencing and alternative splicing of an extended exon 2 of the LAT lncRNA from a newly identified 3' splice site (SS) at the end of the second miRNA of the cluster showed that mdv1-miR-M6 was a 5'-tailed mirtron...
October 7, 2016: RNA Biology
Neel H Shah, Qi Wang, Qingrong Yan, Deepti Karandur, Theresa A Kadlecek, Ian R Fallahee, William P Russ, Rama Ranganathan, Arthur Weiss, John Kuriyan
The sequence of events that initiates T cell signaling is dictated by the specificities and order of activation of the tyrosine kinases that signal downstream of the T cell receptor. Using a platform that combines exhaustive point-mutagenesis of peptide substrates, bacterial surface-display, cell sorting, and deep sequencing, we have defined the specificities of the first two kinases in this pathway, Lck and ZAP-70, for the T cell receptor ζ chain and the scaffold proteins LAT and SLP-76. We find that ZAP-70 selects its substrates by utilizing an electrostatic mechanism that excludes substrates with positively-charged residues and favors LAT and SLP-76 phosphosites that are surrounded by negatively-charged residues...
October 4, 2016: ELife
X Y Zhang, N N Zhang, X P Wan, L L Li, X T Zou
This study was conducted to evaluate gene expression of the amino acid transporter in post-hatch pigeon small intestine and the association of pigeon milk amino acid with the above transporter's gene expression. A total of 48 pigeon breeding families were randomly allocated to 8 groups of 6 replicates of one parental pigeon pair and 2 squabs. Samples of pigeon milk and duodenum, jejunum, and ileum were collected on d 1, 2, 3, 4, 6, 8, 10, and 14 post hatch. The results showed that levels of crude protein (8...
October 2, 2016: Poultry Science
Hideo Otsuki, Toru Kimura, Takashi Yamaga, Takeo Kosaka, Jun-Ichi Suehiro, Hiroyuki Sakurai
BACKGROUND: Leucine stimulates cancer cell proliferation through the mTOR pathway, therefore, inhibiting leucine transporters may be a novel therapeutic target for cancer. L-type amino acid transporter (LAT) 1, a Na(+) -independent amino acid transporter, is highly expressed in many tumor cells. However, leucine transporter(s) in different stages of prostate cancer, particularly in the stages of castration resistance with androgen receptor (AR) expression, is unclear. METHODS: LNCaP and DU145 and PC-3 cell lines were used as a model of androgen dependent, and metastatic prostate cancer...
October 3, 2016: Prostate
W S Nambei, E P Gamba, E Gbangbangai, R M Ouambita, Z Dalengat-Vogbia, R Nana, O Senzongo
OBJECTIVE: The aim of this study was to identify the serogroup and serotypes causing bacterial meningitidis and to determine their prevalence in Bangui, Central African Republic. MATERIALS AND METHODS: Cerebrospinal fluid (CSF) from patients with suspected meningitis were collected and tested with cell counts, Gram staining, cultures, the latex agglutination test (LAT), and real-time PCR that used specific primers and probes for S. pneumoniae, N. meningitidis, and H...
August 1, 2016: Médecine et Santé Tropicales
J Rijckaert, B Pardon, K Verryken, L Van Ham, G van Loon, P Deprez
The aims of this study were to determine reference values for magnetic motor evoked potentials (mMEPs) in calves and the influence of position during examination (standing or lateral recumbency). Reference values were determined using 41 healthy Holstein Friesian bull calves aged 1-10 months; standing and lateral recumbency were examined in 11 calves. Maximal magnetic stimulation was performed at the level of the foramen magnum with a magnetic field of 4 T at the coil surface. In standing position, distinct, reproducible mMEPs were obtained in all calves...
October 2016: Veterinary Journal
D Khoshdel-Navi, A Shabestani-Monfared, M R Deevband, R Abdi, M Nabahati
BACKGROUND: The most efficient application of ionizing radiation is serving medical purposes and using this radiation has caused people to learn that artificial sources of radiation exposure among these resources can be of highest exposure rate. OBIECTIVE: The present study is aimed at initially establishing a baseline for local-reference dose level in Mazandaran, Iran in 12 projections of the most conventional x-ray examination. METHODS: In this study, 13 public hospitals in Mazandaran province were selected for review and required data collected for ten adult patients with mean weight of 70±10kg in each projection...
June 2016: Journal of Biomedical Physics & Engineering
Claire Colas, Peter Man-Un Ung, Avner Schlessinger
The human Solute Carrier (SLC) transporters are important targets for drug development. Structure-based drug discovery for SLC transporters requires the description of their structure, dynamics, and mechanism of interaction with small molecule ligands and ions. The recent determination of atomic structures of human SLC transporters and their homologs, combined with improved computational power and prediction methods have led to an increased applicability of structure-based drug design methods for human SLC members...
June 1, 2016: MedChemComm
Massimo Busin, Claudia Breda, Marina Bertolin, Cristina Bovone, Diego Ponzin, Stefano Ferrari, Vanessa Barbaro, Hossein Mostafa Elbadawy
PURPOSE: To determine whether limbal epithelial stem cells (LESCs) repopulate the site harvested for limbal autograft transplantation (LAT), the expression of LESCs markers was evaluated in bioptic specimens obtained from the donor area 12 months or more after surgery. DESIGN: Interventional case series. PARTICIPANTS: Patients who underwent LAT for unilateral acquired limbal stem cell deficiency after chemical burn. METHODS: Corneal limbal explants were obtained from 2 sites, the harvested area and the untouched control area, in the donor eyes of 6 patients who previously underwent LAT for unilateral acquired limbal stem cell deficiency after chemical burn...
September 21, 2016: Ophthalmology
Y Liu, H L Yang, F F Zhong, J Y Fan
BACKGROUND: The latency-associated transcript (LAT) gene of herpes simplex virus (HSV)-2 is the only detectable viral gene expressed during latent infection in neurons. LAT inhibits apoptosis and maintains latency by promoting the survival of infected neurons. However, whether LAT functions during HSV-2 infection via its encoded RNAs or via its encoded proteins remain unknown. Increasing evidence has indicated that LAT is likely to functionally promote the establishment of latent infection via LAT-encoded microRNAs (miRNAs)...
October 2016: Clinical and Experimental Dermatology
Mariya Stoilova, Sasha Roseneil, Julia Carter, Simon Duncan, Miranda Phillips
This article explores how people who live apart from their partners in Britain describe and understand 'family'. It investigates whether, and how far, non-cohabiting partners, friends, 'blood' and legal ties are seen as 'family', and how practices of care and support, and feelings of closeness are related to these constructions. It suggests that people in LAT relationships creatively draw and re-draw the boundaries of family belonging in ways that involve emotionally subjective understandings of family life, and that also refer to normative constructions of what 'family' ought to be, as well as to practical recognitions of lived family 'realities'...
September 19, 2016: British Journal of Sociology
Xingli Xu, Shengtao Fan, Jienan Zhou, Ying Zhang, Yanchun Che, Hongzhi Cai, Lichun Wang, Lei Guo, Longding Liu, Qihan Li
BACKGROUND: UL7, a tegument protein of Herpes Simplex Virus type I (HSV-1), is highly conserved in viral infection and proliferation and has an unknown mechanism of action. METHODS: A HSV-1 UL7 mutant (UL7-MU) was constructed using the CRISPR-cas9 system. The replication rate and plaque morphology were used to analyze the biological characteristics of the wild-type (WT), UL7-MU and MU-complemented P1 viruses. The virulence of the viruses was evaluated in mice. Real-time RT-qPCR and ChIP assays were used to determine the expression levels of relevant genes...
2016: Virology Journal
Z W de Beer, T A Duong, M J Wingfield
One of the causal agents of human sporotrichosis, Sporothrix schenckii, is the type species of the genus Sporothrix. During the course of the last century the asexual morphs of many Ophiostoma spp. have also been treated in Sporothrix. More recently several DNA-based studies have suggested that species of Sporothrix and Ophiostoma converge in what has become known as Ophiostoma s. lat. Were the one fungus one name principles adopted in the Melbourne Code to be applied to Ophiostoma s. lat., Sporothrix would have priority over Ophiostoma, resulting in more than 100 new combinations...
2016: Studies in Mycology
Francesco Vetrini, Lisa C A D'Alessandro, Zeynep C Akdemir, Alicia Braxton, Mahshid S Azamian, Mohammad K Eldomery, Kathryn Miller, Chelsea Kois, Virginia Sack, Natasha Shur, Asha Rijhsinghani, Jignesh Chandarana, Yan Ding, Judy Holtzman, Shalini N Jhangiani, Donna M Muzny, Richard A Gibbs, Christine M Eng, Neil A Hanchard, Tamar Harel, Jill A Rosenfeld, John W Belmont, James R Lupski, Yaping Yang
Disruption of the establishment of left-right (L-R) asymmetry leads to situs anomalies ranging from situs inversus totalis (SIT) to situs ambiguus (heterotaxy). The genetic causes of laterality defects in humans are highly heterogeneous. Via whole-exome sequencing (WES), we identified homozygous mutations in PKD1L1 from three affected individuals in two unrelated families. PKD1L1 encodes a polycystin-1-like protein and its loss of function is known to cause laterality defects in mouse and medaka fish models...
October 6, 2016: American Journal of Human Genetics
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