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https://www.readbyqxmd.com/read/27932918/salix-transect-of-europe-variation-in-ploidy-and-genome-size-in-willow-associated-common-nettle-urtica-dioica-l-sens-lat-from-greece-to-arctic-norway
#1
Quentin Cronk, Oriane Hidalgo, Jaume Pellicer, Diana Percy, Ilia J Leitch
BACKGROUND: The common stinging nettle, Urtica dioica L. sensu lato, is an invertebrate "superhost", its clonal patches maintaining large populations of insects and molluscs. It is extremely widespread in Europe and highly variable, and two ploidy levels (diploid and tetraploid) are known. However, geographical patterns in cytotype variation require further study. NEW INFORMATION: We assembled a collection of nettles in conjunction with a transect of Europe from the Aegean to Arctic Norway (primarily conducted to examine the diversity of Salix and Salix-associated insects)...
2016: Biodiversity Data Journal
https://www.readbyqxmd.com/read/27928016/promising-role-of-toll-like-receptor-8-agonist-in-concert-with-prostratin-for-activation-of-silent-hiv
#2
M A Rochat, E Schlaepfer, R F Speck
: The persistence of latently HIV-infected cells in patients under combined anti-retroviral treatment (cART) remains the major hurdle for HIV eradication. Thus far, individual compounds have not been sufficiently potent to reactivate latent virus and guarantee its elimination in vivo Thus, we hypothesized that transcriptional enhancers, in concert with compounds triggering the innate immune system, are more efficient in reversing latency by creating a Th1 supportive milieu that acts against latently HIV-infected cells at various levels...
December 7, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27917060/antarctotrechus-balli-sp-n-carabidae-trechini-the-first-ground-beetle-from-antarctica
#3
Allan C Ashworth, Terry L Erwin
Fossil elytra of a small trechine carabid are reported from the Oliver Bluffs on the Beardmore Glacier at lat. 85°S. They were compared with counterparts from the extant genera Trechisibus, Tasmanorites, Oxytrechus and Pseudocnides. The fossils share some characters but are sufficiently different to be described as a new genus and species. We named the new species Antarctotrechus balli in honour of George E. Ball who made major contributions to the study of carabids through his own research and the training of students while at the University of Alberta, Edmonton, Alberta, Canada...
2016: ZooKeys
https://www.readbyqxmd.com/read/27916025/the-role-of-the-extracellular-biophysical-cues-in-modulating-hippo-yap-pathway
#4
Jung-Soon Mo
The Hippo signaling pathway plays an essential role in adult tissue homeostasis and organ size control. In Drosophila and vertebrates, it consists of a highly conserved kinase cascade, which involve MST and Lats that negatively regulate the activity of downstream transcription coactivators, YAP and TAZ. Through its interaction with TEADs and other transcription factors, they mediate both proliferative and antiapoptotic gene expression and thus regulate tissue repair and regeneration. Dysregulation or mutation of the Hippo pathway is linked to tumorigenesis and cancer development...
December 5, 2016: BMB Reports
https://www.readbyqxmd.com/read/27911113/a-tribute-to-professor-steven-l-wechsler-1948-2016-the-man-and-the-scientist
#5
Anthony B Nesburn, Lbachir BenMohamed
Professor Steven L. Wechsler, a world-renowned eye researcher and virologist, passed away unexpectedly on June 12, 2016 at the age of 68. Many scientists came to know Professor Wechsler as a gifted researcher in the field of ocular Herpes Simplex Virus (HSV-1) latency, reactivation, and pathogenesis. Professor Wechsler published over 150 peer-reviewed scientific papers during his career, pushing forward the frontiers of his field eye research. His colleagues would say, 'Steve literally wrote the book on herpes latency and reactivation...
December 2, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27900521/-18-f-fluorodihydroxyphenylalanine-pet-ct-in-pheochromocytoma-and-paraganglioma-relation-to-genotype-and-amino-acid-transport-system-l
#6
Chloé C Feral, Floriane S Tissot, Lionel Tosello, Nicolas Fakhry, Fréderic Sebag, Karel Pacak, David Taïeb
PURPOSE: F-FDOPA is a highly sensitive and specific radiopharmaceutical for pheochromocytoma and paraganglioma (PPGL) imaging. However, (18)F-FDOPA might be falsely negative in these tumors, especially those related to mutations in succinate dehydrogenase genes (SDHx). The aim of the present study was to evaluate the relationship between expression of L-DOPA transporters and (18)F-FDOPA PET imaging results in PPGL. METHODS: From 2007 to 2015, 175 patients with non-metastatic PPGL were evaluated by (18)F-FDOPA PET/CT for initial diagnosis/staging and follow-up...
November 29, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27896837/cd6-and-linker-of-activated-t-cells-are-potential-interaction-partners-for-t-cell-specific-adaptor-protein
#7
Cecilie Dahl Hem, Marianne Ekornhol, Stine Granum, Vibeke Sundvold-Gjerstad, Anne Spurkland
The T cell specific adaptor protein (TSAd) contains several protein interaction domains, and is merging as a modulator of T cell activation. Several interaction partners for the TSAd proline rich region and phosphotyrosines have been identified, including the Src and Tec family kinases Lymphocyte specific protein tyrosine kinase (Lck) and Interleukin 2-Inducible T-cell kinase (Itk). Via its Src homology 2 (SH2) domain, TSAd may thus function as a link between these enzymes and other signaling molecules. However, few binding partners to the TSAd SH2 domain in T cells are hitherto known...
November 29, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27895016/are-prophylactic-and-therapeutic-target-concentrations-different-the-case-of-lopinavir-ritonavir-or-lamivudine-administered-to-infants-for-the-prevention-of-mother-to-child-hiv-1-transmission-during-breastfeeding
#8
Frantz Foissac, Jörn Blume, Jean-Marc Tréluyer, Thorkild Tylleskär, Chipepo Kankasa, Nicolas Meda, James K Tumwine, Mandisa Singata-Madliki, Kim Harper, Silvia M Illamola, Naïm Bouazza, Nicolas Nagot, Philippe Van de Perre, Stéphane Blanche, Déborah Hirt
The ANRS 12174 trial assessed the efficacy and tolerance of LPV/r versus 3TC prophylaxis administered to breastfed infants, whose HIV-infected mothers were not on ART. In this sub-study, we assessed LPV/r and 3TC pharmacokinetics to evaluate the percentage of infants with therapeutic plasma concentrations and to discuss these data in the context of a prophylactic treatment. Infants from the South African trial site underwent blood sampling for pharmacokinetic study at week 6, 26 and 38 of life. We applied a Bayesian approach to derive the 3TC and LPV pharmacokinetic parameters based on previously published pharmacokinetic models for HIV-infected children...
November 28, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27894387/-effect-of-hydrocinnamoyl-l-valyl-pyrrolidine-on-healing-quality-of-deep-partial-thickness-scald-wound-in-mice
#9
M L Yang, Y H Li, Q Tan, J T Li, L L Que
Objective: To observe the effect of Toll interleukin-1 recptor homology/BB-loop mimetic hydrocinnamoyl-L-valyl pyrrolidine (AS-1) on the healing quality of deep partial-thickness scald wound in mice. Methods: Forty-two adult C57BL/6 mice were divided into sham injury group (SI), scald group (S), early AS-1 treatment group (EAT), early dimethyl sulfoxide (DMSO) control group (EDC), late AS-1 treatment group (LAT), late DMSO control group (LDC) according to the random number table, with 7 mice in each group. Mice in group SI were sham injured without other treatment...
November 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/27893478/loads-and-movement-speeds-dictate-differences-in-power-output-during-circuit-training
#10
Kirk B Roberson, Sean Chowdhari, Morgan White, Joseph F Signorile
Power training has become a common exercise intervention for improving muscle strength, power, and physical function, while reducing injury risk. Few studies, however, have evaluated acute load changes on power output during traditional resistance-training protocols. Therefore, the aim of this study was to quantify the effects of different loading patterns on power output during a single session of circuit resistance training (CRT). Nine males (age=19.4±0.9 y) and eleven females (age=20.6±1.6 y) completed three CRT protocols during separate testing sessions using seven pneumatic exercises...
November 16, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27885631/the-glutamine-transporters-and-their-role-in-the-glutamate-gaba-glutamine-cycle
#11
Renata Leke, Arne Schousboe
Glutamine is a key amino acid in the CNS, playing an important role in the glutamate/GABA-glutamine cycle (GGC). In the GGC, glutamine is transferred from astrocytes to neurons, where it will replenish the inhibitory and excitatory neurotransmitter pools. Different transporters participate in this neural communication, i.e., the transporters responsible for glutamine efflux from astrocytes and influx into the neurons, such as the members of the SNAT, LAT, y(+)LAT, and ASC families of transporters. The SNAT family consists of the transporter isoforms SNAT3 and SNAT5 that are related to efflux from the astrocytic compartment, and SNAT1 and SNAT2 that are associated with glutamine uptake into the neuronal compartment...
2016: Advances in Neurobiology
https://www.readbyqxmd.com/read/27879624/transcriptome-analysis-identifies-key-candidate-genes-mediating-purple-ovary-coloration-in-asiatic-hybrid-lilies
#12
Leifeng Xu, Panpan Yang, Suxia Yuan, Yayan Feng, Hua Xu, Yuwei Cao, Jun Ming
Lily tepals have a short lifespan. Once the tepals senesce, the ornamental value of the flower is lost. Some cultivars have attractive purple ovaries and fruits which greatly enhance the ornamental value of Asiatic hybrid lilies. However, little is known about the molecular mechanisms of anthocyanin biosynthesis in Asiatic hybrid lily ovaries. To investigate the transcriptional network that governs purple ovary coloration in Asiatic hybrid lilies, we obtained transcriptome data from green ovaries (S1) and purple ovaries (S2) of Asiatic "Tiny Padhye"...
November 20, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27876957/diagnosis-of-cystic-echinococcosis-in-buffaloes-by-native-8%C3%A2-kda-antigen-using-latex-agglutination-test-lat
#13
A Sheeba, A Sangaran, B R Latha
The dog tapeworm Echinococcusgranulosus is the causative agent of cystic hydatid disease in domestic/wild herbivores animals and man. Accurate immunodiagnosis of the infection requires highly specific and sensitive antigens. The aim of this study was to develop and evaluate immunoassays with principles of precipitation, agglutination for the identification of buffaloes infected with hydatid cyst which would allow the monitoring of animals from endemic areas and identifying infected animals prior to slaughter...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27876929/branchial-cymothoids-infesting-the-marine-food-fishes-of-malabar-coast
#14
Aneesh Panakkool-Thamban, Helna Ameri Kottarathil, Sudha Kappalli
Occurrence of cymothoid isopods parasitizing the branchial chamber of marine food fishes along the Malabar coast was investigated. Live and fresh fishes collected from the Ayyikkara fish landing center (Lat. 11°51'N, Long. 75°22'E; Malabar coast, India) were subjected to the thorough observation for the presence of branchial cymothoids for 3 consecutive years (November 2009-November 2012). Among the recovered cymothoids, 11 species were branchial residents belonging to 6 genera; the species include Agarna malayi, Catoessa gruneri, C...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27876472/evaluation-of-recombinant-antigens-in-combination-and-single-formula-for-diagnosis-of-feline-toxoplasmosis
#15
Abdelbaset Eweda Abdelbaset, Hend Alhasan, Doaa Salman, Mohamed Hassan Karram, Mahmoud Abd Ellah Rushdi, Xuan Xuenan, Makoto Igarashi
Cats are the only definitive hosts of Toxoplasma gondii and constitute an essential source of infection to all warm blooded animals and humans. Diagnosis of T. gondii infection in cats is fundamental for proper management and control of infection in humans and animals. In the current study, we have evaluated the diagnostic performance of tachyzoite lysate antigen (TLA) and different T. gondii recombinant antigens including surface antigen 2 (SAG2), dense granule proteins 2, 6, 7, 15 (GRA2, GRA6, GRA7, GRA15) and microneme 10 protein (MIC10) in immunoglobulin G enzyme linked-immunosorbent assay (IgG ELISA) using cat serum samples, with reference to latex agglutination test (LAT)...
November 19, 2016: Experimental Parasitology
https://www.readbyqxmd.com/read/27875277/development-of-nanoscale-structure-in-lat-based-signaling-complexes
#16
Valarie A Barr, Eilon Sherman, Jason Yi, Itoro Akpan, Alexandre K Rouquette-Jazdanian, Lawrence E Samelson
The adapter molecule Linker for Activation of T cells (LAT) plays a critical role in forming signaling complexes induced by stimulation of the T cell receptor (TCR). These multi-molecular complexes are dynamic structures that activate highly regulated signaling pathways. Previously, we demonstrated nanoscale structure in LAT-based complexes where the adapter SLP-76 localizes to the periphery of LAT clusters. In this study, we show that initially LAT and SLP-76 are randomly dispersed throughout the clusters that form upon TCR engagement...
November 10, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/27872946/implementation-of-image-guided-intensity-modulated-accelerated-partial-breast-irradiation-three-year-results-of-a%C3%A2-phase%C3%A2-ii-clinical-study
#17
Norbert Mészáros, Tibor Major, Gábor Stelczer, Zoltán Zaka, Emőke Mózsa, Dávid Pukancsik, Zoltán Takácsi-Nagy, János Fodor, Csaba Polgár
PURPOSE: To report 3‑year results of accelerated partial breast irradiation (APBI) using image-guided intensity-modulated radiotherapy (IG-IMRT) following breast conserving surgery (BCS) for low-risk early invasive breast cancer. PATIENTS AND METHODS: Between July 2011 and March 2014, 60 patients with low-risk early invasive breast cancer underwent BCS and were enrolled in this phase II prospective study. The total dose was 36.9 Gy (9 fractions of 4.1 Gy, two fractions/day)...
November 21, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27871754/farmland-atmosphere-feedbacks-amplify-decreases-in-diffuse-nitrogen-pollution-in-a-freeze-thaw-agricultural-area-under-climate-warming-conditions
#18
Xiang Gao, Wei Ouyang, Zengchao Hao, Yandan Shi, Peng Wei, Fanghua Hao
Although climate warming and agricultural land use changes are two of the primary instigators of increased diffuse pollution, they are usually considered separately or additively. This likely lead to poor decisions regarding climate adaptation. Climate warming and farmland responses have synergistic consequences for diffuse nitrogen pollution, which are hypothesized to present different spatio-temporal patterns. In this study, we propose a modeling framework to simulate the synergistic impacts of climate warming and warming-induced farmland shifts on diffuse pollution...
November 18, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27863277/vitamin-d-supplementation-affects-the-igf-system-in-men-after-acute-exercise
#19
Rachel L Darr, Kathleen J Savage, Mark Baker, Gregory E Wilding, Amy Raswalsky, Todd Rideout, Richard W Browne, Peter J Horvath
OBJECTIVE: Contradictory data between the Insulin-Like Growth Factor System (IGF) system and exercise may be due to alteration in IGF binding proteins. Vitamin D (D) deficiency has been related to muscle weakness and Insulin Like Growth Factor Binding Protein 3 (IGFBP3). A Vit. D and acute exercise merge is proposed to modify the IGF system. DESIGN: D insufficient and deficient men (39.0±8.6yo with serum D (25OH D) 20.0±7.7ng/mL) did 1h of stretching (ST), aerobic (AB), and resistance (RT) exercises, before and after 28d of 4000IU/d Vit...
November 5, 2016: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/27850325/686-telavancin-observational-use-registry-preliminary-results-for-bacteremia-and-endocarditis
#20
Bruce Friedman, Adam Bressler, Kerry Cleveland, Asma Lat, Matthew Helgeson, Claire Sherman, Bibiana Castaneda-Ruiz
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
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