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Acute coronary syndroms

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https://www.readbyqxmd.com/read/29666900/polymer-free-biolimus-a9-coated-stent-for-primary-percutaneous-coronary-intervention
#1
D J H Lee, J K K Loh, F H Jafary, H H Ho, T Watson, H-P Stoll, P J L Ong
BACKGROUND: The polymer-free biolimus-A9 drug-coated stent (DCS) was reported to have superior safety and efficacy outcomes compared with a bare metal stent in the LEADERS FREE trial of high-bleeding-risk patients with acute coronary syndrome and on dual antiplatelet treatment (DAPT) for 1 month. The aim of this investigation was to evaluate the DCS in a consecutive cohort of patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PPCI)...
April 17, 2018: Herz
https://www.readbyqxmd.com/read/29666606/commentary-baseline-adiponectin-concentration-and-clinical-outcomes-among-patients-with-diabetes-and-recent-acute-coronary-syndrome-in-the-examine-trial
#2
COMMENT
Jan Brož, Marek Brabec, Milan Kvapil, Jan Polák
No abstract text is available yet for this article.
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29664430/-kounis-syndrome-a-paradoxal-non-st-elevation-myocardial-infarction-case-after-triamcinolone-treatment-for-dermatitis
#3
Mücahid Yılmaz, Hasan Korkmaz
Kounis syndrome is defined as the clinical development of acute coronary syndrome caused by the activation of inflammatory cells due to an allergy, hypersensitivity, anaphylaxis, or anaphylactic reaction. Corticosteroids that are used in the treatment of many inflammatory conditions may paradoxically cause allergic reactions and even anaphylaxis. This article is a description of the case of a 52-yearold female patient who had a non-ST elevation myocardial infarction after the administration of triamcinolone that was relieved with antihistaminic treatment...
April 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29664423/long-term-follow-up-of-antithrombotic-management-patterns-in-acute-coronary-syndrome-patients
#4
Fatih Sinan Ertaş, Lale Tokgozoglu
OBJECTIVE: The aim of this study was to evaluate the longterm, post-discharge follow-up of antithrombotic management patterns (AMPs), clinical outcomes, and real-life health status of patients hospitalized acute coronary syndrome (ACS). METHODS: A total of 1034 patients hospitalized for ACS within 24 hours of symptom onset who survived to discharge were included. Of those, 514 had ST-segment elevation myocardial infarction (STEMI) and 520 had unstable angina (UA)/non-STEMI (NSTEMI)...
April 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29664343/peripheral-arterial-disease-changes-in-clinical-outcomes-and-therapeutic-strategies-in-two-cohorts-from-2002-to-2008-and-from-2008-to-2014-a-population-based-study
#5
Marta Baviera, Vittorio Bertelè, Fausto Avanzini, Tommaso Vannini, Mauro Tettamanti, Ida Fortino, Angela Bortolotti, Luca Merlino, Maria Carla Roncaglioni
Background The aim of our study was to evaluate whether treatments for peripheral artery disease changed in two different cohorts identified in 2002 and 2008, and whether this had an impact on mortality and major clinical outcomes after six years of follow-up. Methods Using administrative health databases of the largest region in Northern Italy, we identified patients admitted to hospital for peripheral artery disease in 2002 and 2008. Both cohorts were followed for six years. All cause death, acute coronary syndrome, stroke and major amputations, cardiovascular prevention drugs and revascularization procedures were collected...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29663994/-predictive-value-of-early-phrase-echocardiography-and-cardiac-biological-markers-in-patients-with-severe-sepsis-a-five-year-single-center-retrospective-study
#6
Xuefeng Zang, Wei Chen, Bo Sheng, Lei Zhao, Xuyun Gu, Jie Zhen, Ping Liu
OBJECTIVE: To assess the predictive value of early phrase echocardiography and cardiac biomarkers in patients with severe sepsis. METHODS: A retrospective analysis of severe septic patients (patients with acute coronary syndrome and end stage renal disease were excluded) in department of intensive care unit of Capital Medical University Affiliated Beijing Shijitan Hospital from January 2013 to December 2017 was conducted. The acute physiology and chronic health evaluation II (APACHE II) score, N-terminal prohormone of brain natriuretic peptide (NT-proBNP), cardiac troponin I (cTnI), myoglobin (MYO), creatine kinase (CK), MB isoenzyme of creatine kinase (CK-MB) within 6 hours after admission, and bedside echocardiography indexes [left ventricular ejection fraction (LVEF), the ratio of the peak blood flow velocity in the early stage of the mitral valve and the peak blood flow rate of the mitral valve (E/A ratio)] within 6 hours after diagnosis were recorded...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29663124/regional-variations-in-hospital-management-and-post-discharge-mortality-in-patients-with-non-st-segment-elevation-acute-coronary-syndrome
#7
Héctor Bueno, Xavier Rossello, Stuart Pocock, Frans Van de Werf, Chee Tang Chin, Nicolas Danchin, Stephen W-L Lee, Jesús Medina, Ana Vega, Yong Huo
BACKGROUND: Therapeutic variability not explained by patient clinical characteristics is a potential source of avoidable morbidity and mortality. We aimed to explore regional variability in the management and mortality of patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS). METHODS AND RESULTS: 11,931 NSTE-ACS hospital survivors enrolled in two prospective registries: EPICOR [5625 patients, 555 hospitals, 20 countries in Europe (E) and Latin America (LA), September 2010-March 2011] and EPICOR Asia (6306 patients, 218 hospitals, 8 countries, June 2011-May 2012) were compared among eight pre-defined regions: Northern E (NE), Southern E (SE), Eastern E (EE); Latin America (LA); China (CN), India (IN), South-East Asia (SA), and South Korea, Hong Kong and Singapore (KS)...
April 16, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29662511/treatment-of-coronary-in-stent-restenosis-a-systematic-review
#8
REVIEW
Leos Pleva, Pavel Kukla, Ota Hlinomaz
Coronary stent implantation has significantly improved percutaneous coronary intervention and enabled the management of early complications of plain balloon angioplasty. However, a new complication has accompanied these improvements: in-stent restenosis (ISR) arising from neointimal hyperplasia. ISR after coronary angioplasty is currently one of the main limitations of this method, leading to the recurrence of exertional angina pectoris or acute coronary syndromes. The clinical incidence of ISR after bare-metal stent (BMS) implantation is approximately 20%-35%...
February 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29662508/obstructive-sleep-apnea-is-associated-with-severity-and-long-term-prognosis-of-acute-coronary-syndrome
#9
Shuo Jia, Yu-Jie Zhou, Yi Yu, Si-Jing Wu, Yan Sun, Zhi-Jian Wang, Xiao-Li Liu, Bright Eric King, Ying-Xin Zhao, Dong-Mei Shi, Yu-Yang Liu, Zhi-Ming Zhou
Background: Obstructive sleep apnea (OSA) is a common disease in patients with acute coronary syndrome (ACS) and associated with an increased risk of fatal and nonfatal cardiovascular events. However, most patients in previous study were treated with bare metal stents and the sample sizes were relatively low. The goal of this study was to evaluate the influence of OSA on the severity and prognosis of patients admitted for ACS. Methods: In this prospective cohort study, we enrolled patients with ACS who were hospitalized for coronary angiogram/percutaneous coronary intervention and undergone polysomnography...
February 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29661666/pseudo-wellens-syndrome-and-intermittent-left-bundle-branch-block-in-a-case-of-acute-cholecystitis
#10
Steffen Grautoff, Martin Balog, Guenther Winde
We present a case of a 54-year-old male patient who was admitted to our Emergency Department (ED) with localized epigastric pain. Inflammation markers, ultrasound, and CT scan were inconsistent with an initial diagnosis of cholecystitis. However, there was additional evidence of cholecystolithiasis. The ECG showed new anterior biphasic T waves typical for a Wellens' type A ECG. Additionally, the patient had an intermittent left bundle branch block (LBBB). The diagnostic challenges in differentiating possible diagnoses will be described, to which in this case, were either acute cholecystitis or acute coronary syndrome (ACS)...
April 7, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29659887/homeostasis-model-assessment-of-insulin-resistance-and-survival-in-patients-with-diabetes-and-acute-coronary-syndrome
#11
Barbara E Stähli, Anna Nozza, Ilse C Schrieks, John B Buse, Klas Malmberg, Linda Mellbin, Bruce Neal, Stephen J Nicholls, Lars Rydén, Anders Svensson, Hans Wedel, Arlette Weichert, A Michael Lincoff, Diederick E Grobbee, Jean-Claude Tardif, Gregory G Schwartz
Purpose: Insulin resistance has been linked to development and progression of atherosclerosis and is present in most patients with type 2 diabetes (T2D). Whether the degree of insulin resistance predicts adverse outcomes in patients with T2D and acute coronary syndrome (ACS) is uncertain. Methods: The AleCardio trial compared the peroxisome proliferator-activated receptor-α/γ agonist aleglitazar with placebo in patients with T2D and recent ACS. In participants not treated with insulin, we determined whether baseline homeostasis model assessment of insulin resistance (HOMA-IR, n=4303) or the change in HOMA-IR on assigned study treatment (n=3568) was related to the risk of death or major adverse cardiovascular events (MACE: cardiovascular death, myocardial infarction, and stroke) in unadjusted and adjusted models...
April 6, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29659846/is-administration-of-dual-antiplatelet-therapy-beneficial-for-patients-following-off-pump-coronary-artery-bypass-grafting
#12
Maciej Peksa, Sleiman Sebastian Aboul-Hassan, Jakub Marczak, Romuald Cichon
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether administration of dual-antiplatelet therapy (DAPT) following off-pump coronary artery bypass grafting (OPCAB) would improve postoperative clinical outcomes or minimize the incidence of postoperative graft failure. In total, 101 papers were found using the reported search, 14 of which represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated...
April 5, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29657734/treatment-of-a-patient-with-acute-aortic-dissection-using-extracorporeal-cardiopulmonary-resuscitation-after-an-out-of-hospital-cardiac-arrest-a-case-report
#13
Takahiro Yukawa, Kazuhiro Sugiyama, Kazuki Miyazaki, Takahiro Tanabe, Susumu Ishikawa, Yuichi Hamabe
Case: Circulatory support using veno-arterial extracorporeal membrane oxygenation for aortic disease is conventionally contraindicated. In this case, a 66-year-old man experienced cardiopulmonary arrest caused by acute aortic dissection. When exercising in the gym, he experienced chest discomfort, so the staff immediately called an ambulance. While in the ambulance, he experienced cardiopulmonary arrest. His initial electrocardiogram showed ventricular fibrillation. At the emergency department, we immediately performed extracorporeal cardiopulmonary resuscitation...
April 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29656987/differential-prognostic-impact-on-mortality-of-myocardial-infarction-compared-with-bleeding-severity-in-contemporary-acute-coronary-syndrome-patients
#14
Berenice Caneiro-Queija, Emad Abu-Assi, Sergio Raposeiras-Roubín, Sergio Manzano-Fernández, Pedro Flores Blanco, Ángel López-Cuenca, Rafael Cobas-Paz, Miriam Gómez-Molina, José Manuel Rodríguez-Rodríguez, Francisco Calvo-Iglesias, Mariano Valdés-Chávarri, Andrés Íñiguez-Romo
INTRODUCTION AND OBJECTIVES: The impact on mortality of myocardial infarction (MI) compared with the specific degree of bleeding severity occurring after discharge in acute coronary syndrome is poorly characterized. Defining this relationship may help to achieve a favorable therapeutic risk-benefit balance. METHODS: Using Cox-based shared frailty models, we assessed the relationship between mortality and postdischarge MI and bleeding severity-graded according to Bleeding Academic Research Consortium (BARC)-in 4229 acute coronary syndrome patients undergoing in-hospital coronary arteriography between January 2012 and December 2015...
April 12, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29655953/risk-factors-predisposing-to-acute-coronary-syndromes-in-young-women-%C3%A2-45-years-of-age
#15
Maciej Bęćkowski, Marek Gierlotka, Mariusz Gąsior, Lech Poloński, Tomasz Zdrojewski, Rafał Dąbrowski, Jarosław Karwowski, Ilona Kowalik, Wojciech Drygas, Hanna Szwed
BACKGROUND: Acute coronary syndromes (ACS) are rare in young women. The purpose of this study was to characterize risk factors (RF) predisposing to ACS in young women and evaluate possible age-related differences. METHODS AND RESULTS: We studied 1941 young women with ACS aged ≤45 years (≤45ACS) from the PL-ACS registry and compared them with two control groups: 4275 women aged 63-64 years with ACS (63-64ACS) from the PL-ACS registry and 1170 young healthy women aged ≤45 years (≤45H) without confirmed coronary artery disease (CAD), from two national, representative, cross-sectional population health surveys, NATPOL 2011 and WOBASZ...
April 4, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29655952/population-level-incidence-and-outcomes-of-myocardial-infarction-with-non-obstructive-coronary-arteries-minoca-insights-from-the-alberta-contemporary-acute-coronary-syndrome-patients-invasive-treatment-strategies-coapt-study
#16
Kevin R Bainey, Robert C Welsh, Wendimagegn Alemayehu, Cynthia M Westerhout, Dean Traboulsi, Todd Anderson, Neil Brass, Paul W Armstrong, Padma Kaul
BACKGROUND: Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a known clinical conundrum with limited investigation. Using a large population-based cohort, we examined the incidence, demographic profile, use of evidence-based medicines (EBM) and clinical outcomes of MINOCA patients. METHODS: Patients hospitalized with a primary diagnosis of MI who underwent coronary angiography between 01/04/2002 and 31/03/2014 in Alberta, Canada, were included in the study...
April 4, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29655881/racial-differences-in-quality-of-care-and-outcomes-after-acute-coronary-syndrome
#17
Celina M Yong, Leo Ungar, Freddy Abnousi, Steven M Asch, Paul A Heidenreich
Guideline adherence and variation in acute coronary syndrome (ACS) outcomes by race in the modern era of drug-eluting stents (DES) are not well understood. Previous studies also fail to capture rapidly growing minority populations, such as Asians. A retrospective analysis of 689,238 hospitalizations for ACS across all insurance types from 2008 to 2011 from the Healthcare Cost and Utilization Project database was performed to determine whether quality of ACS care and mortality differ by race (white, black, Asian, Hispanic, or Native American), with adjustment for patient clinical and demographic characteristics and clustering by hospital...
March 13, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29655571/a-rapid-access-chest-pain-clinic-racpc-initial-australian-experience
#18
C Yu, M J Sheriff, A C C Ng, S Brazete, J Gullick, D B Brieger, L Kritharides, H C Lowe
Chest pain is the second most common presenting symptom to emergency departments (ED) in Australia, although up to 85% of these patients do not have an acute coronary syndrome (ACS). Cardiologist-led rapid access chest pain clinics (RACPC) have been proposed overseas to assist in the management of such patients, with prompt outpatient assessment if patients are deemed low risk and discharged from the ED. The use of RACPCs in Australia has been only recently proposed; we therefore sought to examine one such RACPC in an Australian context...
December 11, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29655567/acute-coronary-syndrome-relationship-between-genetic-variants-and-timi-risk
#19
Viviane do Carmo Vasconcelos de Carvalho, Lílian Caroliny Amorim Silva, Romário Martins Araújo, Fábia Carla da Silva Soares, Maria José Ribeiro Bezerra, Sávio Augusto Vieira de Oliveira, Alex José de Melo Silva, Sérgio Tavares Montenegro, Roberto Pereira Werkhauser, Carlos Gustavo Régis da Silva, Adriana Vieira Gomes, Clarice Neuenschwander Lins de Morais, Silvia Maria Lucena Montenegro
Acute Coronary Syndrome (ACS) is a multifactorial disease, including the genetic factor, caused by coronary artery obstruction by atheroma. Some genetic variants have been described as risk factors for this disease. Its early diagnosis and stratification of risk of death by Thrombolysis in Myocardial Infarction (TIMI) are important. Therefore, we evaluated variants in the IL6R (c950-1722C>T), TNFa (c.-488G>A), LEPR (c.2673+1118C>T) and IL1b (c.-598T>C) genes in relation to TIMI risk, cytokine serum levels, and risk factors for ACS...
April 11, 2018: Cytokine
https://www.readbyqxmd.com/read/29652672/early-discontinuation-of-prasugrel-or-clopidogrel-in-acute-coronary-syndromes-insights-from-the-trilogy-acs-trial
#20
Andrew T Yan, Matthew T Roe, Megan Neely, Derek D Cyr, Harvey White, Keith A A Fox, Dorairaj Prabhakaran, Paul W Armstrong, Erik M Ohman, Shaun G Goodman
BACKGROUND: In the Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes (TRILOGY ACS) trial of patients with non-ST-segment elevation acute coronary syndrome managed medically without revascularization, treated with prasugrel versus clopidogrel for less than or equal to 30 months after index acute coronary syndrome, post-hoc analyses showed a divergence of treatment effect in favor of prasugrel after 12 months. Potential influential factors, including a potential late treatment effect after early study drug discontinuation in the intention-to-treat analysis, have not been explored...
April 12, 2018: Coronary Artery Disease
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