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colorectal cancer And cancer stem cell

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https://www.readbyqxmd.com/read/29765532/chemopreventive-activity-of-celastrol-in-drug-resistant-human-colon-carcinoma-cell-cultures
#1
Helena Moreira, Anna Szyjka, Kazimierz Gąsiorowski
Celastrol (tripterine) a pentacyclic triterpenoid extracted from the roots of Tripterygium wilfordii Hook f., exhibits potent antioxidant and anti-inflammatory activity and also exerts important anti-cancer effects, as induction of apoptosis and lowering the level of drug resistance of several cancers. Increased level of cellular resistance to cytostatic drugs is typical for colorectal cancers, and largely determines the failure of chemotherapy for this tumor. The purpose of our research was to evaluate the chemopreventive effect of celastrol on cultures of colon cancer cells resistant to doxorubicin (LOVO/DX)...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29760071/prdm1-silences-stem-cell-related-genes-and-inhibits-proliferation-of-human-colon-tumor-organoids
#2
Changlong Liu, Carolyn E Banister, Charles C Weige, Diego Altomare, Joseph H Richardson, Carlo M Contreras, Phillip J Buckhaults
PRDM1 is a tumor suppressor that plays an important role in B and T cell lymphomas. Our previous studies demonstrated that PRDM1β is a p53-response gene in human colorectal cancer cells. However, the function of PRDM1β in colorectal cancer cells and colon tumor organoids is not clear. Here we show that PRDM1β is a p53-response gene in human colon organoids and that low PRDM1 expression predicts poor survival in colon cancer patients. We engineered PRDM1 knockouts and overexpression clones in RKO cells and characterized the PRDM1-dependent transcript landscapes, revealing that both the α and β transcript isoforms repress MYC-response genes and stem cell-related genes...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29755667/a-set-of-cancer-stem-cell-homing-peptides-associating-with-the-glycan-moieties-of-glycosphingolipids
#3
Yu-Hsiu Su, Tai-Yun Lin, Hung-Jen Liu, Chin-Kai Chuang
Cancer stem cells (CSCs) are currently believed to be involved in tumor metastasis and relapse. And treatments against CSCs are well concerned issues. Peptides targeting to mouse and human CSCs were screened from an M13 phage display library. The first subset of cancer stem cell homing peptides (CSC HPs), CSC HP-1 to -12, were screened with mouse EMT6 breast cancer stem cells. Among them, CSC HP-1, CSC HP-3, CSC HP-8, CSC HP-9, and CSC HP-10 can bind to mouse CT26 colon CSCs; CSC HP-1, CSC HP-2, CSC HP-3, and CSC HP-8 can bind to mouse Hepa1-6 liver CSCs; as well as CSC HP-1, CSC HP-2, CSC HP-3, CSC HP-8, CSC HP-9, CSC HP-10, and CSC HP-11 can bind to human PANC-1 pancreatic CSCs...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29755662/hotspot-kras-exon-2-mutations-in-cd166-positive-colorectal-cancer-and-colorectal-adenoma-cells
#4
Hung Lai Wong, Lawrence Po Wah Ng, Su Pin Koh, Lawrence Wing Chi Chan, Evelyn Yin Kwan Wong, Vivian Weiwen Xue, Hin Fung Andy Tsang, Amanda Kit Ching Chan, Ka Yue Chiu, Wah Cheuk, Sze Chuen Cesar Wong
Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer deaths worldwide. Recent studies have shown that cancer stem cells (CSCs) are an important cause of tumor recurrence and metastasis. We hypothesized that CSCs marker CD166-positive CRC and colorectal adenoma (CAD) cells consist of more hotspot mutations than CD166-negative CRC and colorectal adenoma cells. To verify this, formalin fixed paraffin embedded tissue specimens from 42 patients each with CRC and CAD were recruited and CD166 immunohistochemical (IHC) staining followed by macrodissection was performed...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29749477/long-non-coding-rna-hoxd-as1-promotes-tumor-progression-and-predicts-poor-prognosis-in-colorectal-cancer
#5
Xiang Li, Xinhan Zhao, Binhui Yang, Yuqing Li, Tao Liu, Linyuan Pang, Zhigang Fan, Wu Ma, Zhongqiu Liu, Zeng Li
Mounting evidence has indicated that long non‑coding RNAs (lncRNA) serve important roles in tumor development. Previous studies have demonstrated that the lncRNA HOXD cluster antisense RNA 1 (HOXD‑AS1) promotes tumor progression in numerous types of cancer; however, the role of HOXD‑AS1 in colorectal cancer (CRC) remains unclear. In the present study, the expression levels of HOXD‑AS1 were detected in CRC tissues and cell lines using quantitative polymerase chain reaction. In addition, the biological effects of HOXD‑AS1 on CRC were evaluated in vitro by cell counting kit‑8, colony formation and Transwell assays, and in vivo by tumorigenesis and metastasis assays...
May 9, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29748374/the-microrna-371-373-cluster-represses-colon-cancer-initiation-and-metastatic-colonization-by-inhibiting-the-tgfbr2-id1-signaling-axis
#6
Pit Ullmann, Fabien Rodriguez, Martine Schmitz, Steffen K Meurer, Komal Qureshi-Baig, Paul Felten, Aurélien Ginolhac, Laurent Antunes, Sonia Frasquilho, Nikolaus Zügel, Ralf Weiskirchen, Serge Haan, Elisabeth Letellier
The vast majority of colorectal cancer (CRC)-related deaths can be attributed to metastatic spreading of the disease. Therefore, deciphering molecular mechanisms of metastatic dissemination is a key prerequisite to improve future treatment options. With this aim, we took advantage of different CRC cell lines and recently established primary cultures enriched in colon cancer stem cells (CSCs) - also known as tumor-initiating cells (TICs) - to identify genes and microRNAs (miRNAs) with regulatory functions in CRC progression...
May 10, 2018: Cancer Research
https://www.readbyqxmd.com/read/29718672/evaluation-of-anti-lgr5-antibodies-by-immunopet-for-imaging-colorectal-tumors-and-development-of-antibody-drug-conjugates
#7
Ali Azhdarinia, Julie Voss, Sukhen C Ghosh, Jo A Simien, Servando Hernandez Vargas, Jie Cui, Wangsheng A Yu, Qingyun Liu, Kendra S Carmon
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) is highly expressed in colorectal tumors and marks colon cancer stem cells that drive tumor growth and metastasis. Recently, we showed that LGR5 is a promising target for antibody-drug conjugate (ADC) therapy. However, it is important to identify LGR5-positive tumors that would respond ADC treatment. Prior to drug conjugation, we evaluated two different anti-LGR5 monoclonal antibodies (mAbs), 8F2 and 9G5, using 89Zr-immunoPET to select the optimal mAb for ADC development and tumor imaging...
May 2, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29715083/effect-of-tissue-factor-on-colorectal-cancer-stem-cells
#8
Hamish William Clouston, Peter Adam Rees, Rebecca Lamb, Sarah Elizabeth Duff, Cliona Clare Kirwan
BACKGROUND/AIM: Tissue factor (TF) expression increases cancer stem cell (CSC) activity in breast and lung cancer. There are ongoing studies focused on targeting CSCs via anti-TF treatment, for breast and lung cancer therapy. Herein, the aim was to determine whether targeting TF could have an anti-CSC therapeutic role in colorectal cancer (CRC). MATERIALS AND METHODS: Evaluation of colonosphere-forming efficiency (CFE) and aldehyde dehydrogenase (ALDH) expression level was used to quantify CSC activity in two CRC cell lines, after TF knockdown (TFKD) or TF over-expression (TFOE)...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29713750/correction-to-wnt-%C3%AE-catenin-signaling-mediates-the-suppressive-effects-of-diallyl-trisulfide-on-colorectal-cancer-stem-cells
#9
Qi Zhang, Xiao-Ting Li, Yue Chen, Jia-Qi Chen, Jian-Yun Zhu, Yu Meng, Xiao-Qian Wang, Yuan Li, Shan-Shan Geng, Chun-Feng Xie, Jie-Shu Wu, Cai-Yun Zhong, Hong-Yu Han
Unfortunately, the online published article has error in Figure 4. The correct Figure 4 is given here.
April 30, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29700375/jib-04-a-small-molecule-histone-demethylase-inhibitor-selectively-targets-colorectal-cancer-stem-cells-by-inhibiting-the-wnt-%C3%AE-catenin-signaling-pathway
#10
Min Seong Kim, Hye In Cho, Hee Jung Yoon, Ye-Hyeon Ahn, Eun Jung Park, Yan Hua Jin, Yeun Kyu Jang
Although several epigenetic modulating drugs are suggested to target cancer stem cells (CSCs), additional identification of anti-CSC drugs is still necessary. Here we showed that JIB-04, a pan-selective inhibitor of histone demethylase(s), was identified as a small molecule that selectively target colorectal CSCs. Our data showed that JIB-04 is capable of reducing self-renewal and stemness of colorectal CSCs in three different colorectal cancer cell lines. JIB-04 significantly attenuated CSC tumorsphere formation, growth/relapse, invasion, and migration in vitro...
April 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29700002/zika-virus-selectively-kills-aggressive-human-embryonal-cns-tumor-cells-in-vitro-and-in-vivo
#11
Carolini Kaid, Ernesto Goulart, Luiz Carlos Caires-Júnior, Bruno Henrique Silva Araujo, Alessandra Soares-Schanoski, Heloisa Maria Siqueira Bueno, Kayque Alves Telles Silva, Renato M Astray, Amanda F Assoni, Antonio F Ribeiro Júnior, Daniella Cristina Ventini, Ana L P Puglia, Roselane P Gomes, Mayana Zatz, Oswaldo K Okamoto
Zika virus (ZIKV) is largely known for causing brain abnormalities due to its ability to infect neural progenitor stem cells (NPC) during early development. Here we show that ZIKV is also capable of infecting and destroying stem-like cancer cells from aggressive human embryonal tumors of the central nervous system (CNS). When evaluating the oncolytic properties of Brazilian Zika virus strain (ZIKVBR) against human breast, prostate, colorectal, and embryonal CNS tumor cell lines, we verified a selective infection of CNS tumor cells followed by massive tumor cell death...
April 26, 2018: Cancer Research
https://www.readbyqxmd.com/read/29693702/glycine-and-succinic-acid-are-effective-indicators-of-the-suppression-of-epithelial-mesenchymal-transition-by-fucoxanthinol-in-colorectal-cancer-stem-like-cells
#12
Masaru Terasaki, Masatoshi Mima, Satoki Kudoh, Tetsuya Endo, Hayato Maeda, Junichi Hamada, Kazumi Osada, Kazuo Miyashita, Michihiro Mutoh
Fucoxanthinol (FxOH) is a strong anticancer metabolite of fucoxanthin that accumulates in abundance in edible brown algae and promises human health benefits. FxOH has been shown to suppress tumorigenicity and sphere formation in human colorectal cancer stem cell (CCSC)-like spheroids (colonospheres, Csps). In the present study, we aimed to clarify the inhibitory activity of FxOH on epithelial-mesenchymal transition (EMT), which is essential for cancer recurrence and distant metastasis, and to identify intracellular low-molecular-weight metabolites that may be useful for evaluating the cellular effects of FxOH on CCSCs...
April 24, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29690669/-lincrna-ror-functions-as-a-cerna-to-regulate-oct4-sox2-and-nanog-expression-by-sponging-mir-145-and-its-effect-on-biologic-characteristics-of-colonic-cancer-stem-cells
#13
Z Y Yan, X C Sun
Objective: To investigate the impact of lincRNA-ROR, a ceRNA by binding miR-145 on the expression of the downstream genes Oct4, Sox2 and Nanog, and related biological characteristics of colon cancer stem cells, and to elucidate the clinical significance of this molecular regulatory network. Methods: Fifty-two cases of colorectal cancer tissue and adjacent tissue were collected at Nanyang City Central Hospital and Nanyang Second Hospital, Henan Province, from 2014 to 2016. Real-time quantitative polymerase chain reaction (qPCR) was used to detect the expression of lincRNA-ROR and miR-145 in colorectal cancer tissue and isolated colon cancer cells...
April 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29689565/ubiquitin-specific-peptidase-22-contributes-to-colorectal-cancer-stemness-and-chemoresistance-via-wnt-%C3%AE-catenin-pathway
#14
Shixiong Jiang, Chenxin Song, Xinyu Gu, Muhong Wang, Dazhuang Miao, Jiachen Lv, Yanlong Liu
BACKGROUND/AIMS: Two major barriers to the successful treatment of colorectal cancer (CRC) are the development of stem cell-like characteristics (stemness) and chemoresistance. Ubiquitin-specific peptidase 22 (USP22) is a deubiquitinating enzyme and putative CRC marker that has emerged as a potential cause of both phenomena in CRC. There is evidence that USP22 acts through the Wnt/β-catenin pathway and that downregulation of the latter may reduce chemoresistance. METHODS: In this study, we used CRC tissue specimens from human patients as well as human CRC cell lines to evaluate the role of USP22 in CRC stemness and chemoresistance in vitro and in vivo...
April 18, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29674637/ube2s-stabilizes-%C3%AE-catenin-through-k11-linked-polyubiquitination-to-promote-mesendoderm-specification-and-colorectal-cancer-development
#15
Zhaoyan Li, Yan Wang, Yadan Li, Wanqi Yin, Libin Mo, Xianghao Qian, Yiran Zhang, Guifen Wang, Fan Bu, Zhiling Zhang, Xiaofang Ren, Baochang Zhu, Chang Niu, Wei Xiao, Weiwei Zhang
The canonical Wnt/β-Catenin signaling pathway is widely involved in regulating diverse biological processes. Dysregulation of the pathway results in severe consequences, such as developmental defects and malignant cancers. Here, we identified Ube2s as a novel activator of the Wnt/β-Catenin signaling pathway. It modified β-Catenin at K19 via K11-linked polyubiquitin chain. This modification resulted in an antagonistic effect against the destruction complex/β-TrCP cascade-orchestrated β-Catenin degradation...
April 19, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29672847/loss-of-n-wasp-drives-early-progression-in-an-apc-model-of-intestinal-tumourigenesis
#16
Hayley T Morris, Loic Fort, Heather J Spence, Rachana Patel, David F Vincent, James H Park, Scott B Snapper, Francis A Carey, Owen J Sansom, Laura M Machesky
N-WASP (WASL) is a widely expressed cytoskeletal signalling and scaffold protein also implicated in regulation of Wnt signalling and homeostatic maintenance of skin epithelial architecture. N-WASP mediates invasion of cancer cells in vitro and its depletion reduces invasion and metastatic dissemination of breast cancer. Given this role in cancer invasion and universal expression in the gastrointestinal tract, we explored a role for N-WASP in the initiation and progression of colorectal cancer. While deletion of N-wasp is not detectably harmful in the murine intestinal tract, numbers of Paneth cells increased, indicating potential changes in the stem cell niche and migration up the crypt-villus axis was enhanced...
April 19, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29667344/concise-review-aggressive-colorectal-cancer-role-of-epithelial-cell-adhesion-molecule-in-cancer-stem-cells-and-epithelial-to-mesenchymal-transition
#17
REVIEW
Maximilian Boesch, Gilbert Spizzo, Andreas Seeber
Colorectal cancer (CRC) is one of the most common malignancies worldwide. In spite of various attempts to ameliorate outcome by escalating treatment, significant improvement is lacking particularly in the adjuvant setting. It has been proposed that cancer stem cells (CSCs) and the epithelial-to-mesenchymal transition (EMT) are at least partially responsible for therapy resistance in CRC. The epithelial cell adhesion molecule (EpCAM) was one of the first CSC antigens to be described. Furthermore, an EpCAM-specific antibody (edrecolomab) has the merit of having launched the era of monoclonal antibody treatment in oncology in the 1990s...
April 17, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29666172/genetic-editing-of-colonic-organoids-provides-a-molecularly-distinct-and-orthotopic-preclinical-model-of-serrated-carcinogenesis
#18
Tamsin R M Lannagan, Young K Lee, Tongtong Wang, Jatin Roper, Mark L Bettington, Lochlan Fennell, Laura Vrbanac, Lisa Jonavicius, Roshini Somashekar, Krystyna Gieniec, Miao Yang, Jia Q Ng, Nobumi Suzuki, Mari Ichinose, Josephine A Wright, Hiroki Kobayashi, Tracey L Putoczki, Yoku Hayakawa, Simon J Leedham, Helen E Abud, Ömer H Yilmaz, Julie Marker, Sonja Klebe, Pratyaksha Wirapati, Siddhartha Mukherjee, Sabine Tejpar, Barbara A Leggett, Vicki L J Whitehall, Daniel L Worthley, Susan L Woods
OBJECTIVE: Serrated colorectal cancer (CRC) accounts for approximately 25% of cases and includes tumours that are among the most treatment resistant and with worst outcomes. This CRC subtype is associated with activating mutations in the mitogen-activated kinase pathway gene, BRAF , and epigenetic modifications termed the CpG Island Methylator Phenotype, leading to epigenetic silencing of key tumour suppressor genes. It is still not clear which (epi-)genetic changes are most important in neoplastic progression and we begin to address this knowledge gap herein...
April 17, 2018: Gut
https://www.readbyqxmd.com/read/29663476/mir-200c-a-tumor-suppressor-that-modulate-the-expression-of-cancer-stem-cells-markers-and-epithelial-mesenchymal-transition-in-colorectal-cancer
#19
Fateme Karimi Dermani, Razieh Amini, Massoud Saidijam, Rezvan Najafi
Colorectal cancer (CRC) is the most frequently diagnosed cancer and the most common gastrointestinal cancer worldwide. Due to the presence of populations of cancer stem cells (CSCs) that cause recurrence, the possibility of cancer treatment is very low. The aim of current study was to evaluate the inhibitory role of miR-200c on EMT, CSCs markers and β-catenin in HCT-116 and SW48 cell lines. The expression of miR-200c, EMT-related genes, CSCs markers, and β-catenin were quantified by qRT-PCR. Further, expression of β-catenin and EMT-related proteins, and migration were analyzed by Western blot, and migration assay kit, respectively...
April 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29662620/promotion-of-malignant-phenotype-after-disruption-of-the-three-dimensional-structure-of-cultured-spheroids-from-colorectal-cancer
#20
Jose M Piulats, Jumpei Kondo, Hiroko Endo, Hiromasa Ono, Takeshi Hagihara, Hiroaki Okuyama, Yasuko Nishizawa, Yasuhiko Tomita, Masayuki Ohue, Kouki Okita, Hidejiro Oyama, Hidemasa Bono, Takashi Masuko, Masahiro Inoue
Individual and small clusters of cancer cells may detach from the edges of a main tumor and invade vessels, which can act as the origin of metastasis; however, the mechanism for this phenomenon is not well understood. Using cancer tissue-originated spheroids, we studied whether disturbing the 3D architecture of cancer spheroids can provoke the reformation process and progression of malignancy. We developed a mechanical disruption method to achieve homogenous disruption of the spheroids while maintaining cell-cell contact...
March 23, 2018: Oncotarget
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