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Hanieh Meteran, Erik Vindbjerg, Sigurd Wiingaard Uldall, Birte Glenthøj, Jessica Carlsson, Bob Oranje
BACKGROUND: Impairments in mechanisms underlying early information processing have been reported in posttraumatic stress disorder (PTSD); however, findings in the existing literature are inconsistent. This current study capitalizes on technological advancements of research on electroencephalographic event-related potential and applies it to a novel PTSD population consisting of trauma-affected refugees. METHODS: A total of 25 trauma-affected refugees with PTSD and 20 healthy refugee controls matched on age, gender, and country of origin completed the study...
May 17, 2018: Psychological Medicine
Lau M Andersen
An important aim of an analysis pipeline for magnetoencephalographic (MEG) data is that it allows for the researcher spending maximal effort on making the statistical comparisons that will answer his or her questions. The example question being answered here is whether the so-called beta rebound differs between novel and repeated stimulations. Two analyses are presented: going from individual sensor space representations to, respectively, an across-group sensor space representation and an across-group source space representation...
2018: Frontiers in Neuroscience
Jeffery Schafer, William Reindel, Robert Steffen, Gary Mosehauer, Joseph Chinn
Background: Sustained digital display viewing reduces eye blink frequency and tear film stability. To retain water and preserve a smooth optical surface, contact lens manufacturers have integrated the humectant polyvinylpyrrolidone (PVP) into silicone hydrogel contact lenses. In this study, extended blink time (EBT) was used to assess visual stability over a prolonged blink interval of two PVP-containing silicone hydrogel lenses, samfilcon A (SAM) and senofilcon A (SEN). Materials and methods: This randomized, bilateral, masked, crossover study assessed lens performance in ten subjects after 16 hours of wear...
2018: Clinical Ophthalmology
Pamela Dalton, Brianna Soreth, Christopher Maute, Carolyn Novaleski, Marcy Banton
OBJECTIVE: Propylene glycol (PG) is a widely used solvent, chemical intermediate and carrier substance for foods, pharmaceutical and cosmetic products. Professional and occupational exposure to PG aerosol and vapor may occur from theatrical smoke generators and during application of deicing products to airplanes. While PG is considered to have low toxicity, the results of one study suggested that brief (1-min) exposure to PG mist elicited ocular and respiratory effects in humans. Because the high concentrations and brief exposure duration in that study were not representative of most occupational exposures, a controlled experimental exposure study was conducted to clarify or confirm the earlier findings...
May 15, 2018: Inhalation Toxicology
Bruce H Thiers
No abstract text is available yet for this article.
June 2018: Journal of the American Academy of Dermatology
Giorgia Sciacca, Alessandra Nicoletti, Giovanni Mostile, Antonina Luca, Loredana Raciti, Valeria Dibilio, Filippo Drago, Salvatore Salomone, Mario Zappia
BACKGROUND: Progressive Supranuclear Palsy (PSP) and Cortico-basal syndrome (CBS) may share similar clinical findings and peculiar tests to distinguish between the two disorders could be useful. We evaluated Blink Reflex (BR) and R2 Blink Reflex Recovery Cycle (R2BRRC), determining diagnostic sensitivity, specificity, positive and negative predictive value of R2BRRC in differentiating PSP from CBS patients. METHODS: This was a prospective data collection study investigating BR and R2BRRC at interstimulus intervals (ISIs) of 100, 150, 200, 300, 400, 500, 750 ms in 12 PSP patients, 8 CBS patients, and 10 controls...
May 13, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Peter D Drummond, Ashlea Bell, Lechi Vo
Exposure to moderate levels of ultraviolet B radiation (UVB) is painless but nevertheless induces an inflammatory response that sensitizes primary afferent nociceptors. Subsequently, heating the UVB-treated site can sensitize spinal nociceptors. We used a repeated-measures design to determine whether heating the UVB-treated site also triggers ipsilateral inhibitory controls. Specifically, a 2-cm diameter site on the forearm of 20 participants was exposed to UVB at twice the minimum erythema dose. 48 h later mechanical and thermal sensitivity had increased at the UVB-treated site, indicating primary hyperalgesia...
May 12, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Benoit Roubinet, Matthias Bischoff, Shamil Nizamov, Sergey Yan, Claudia Geisler, Stefan Stoldt, Gyuzel Y Mitronova, Vladimir N Belov, Mariano L Bossi, Stefan W Hell
Photoactivatable rhodamine spiroamides and spirocyclic diazoketones emerged recently as synthetic markers applicable in multicolor superresolution microscopy. However, their applicability in single molecule localization microscopy (SMLM) is often limited by aggregation, unspecific adhesion and low reactivity caused by insufficient solubility and precipitation from aqueous solutions. We report here two synthetic modifications increasing the polarity of compact polycyclic and hydrophobic labels decorated with a reactive group: attachment of 3-sulfo-L-alanyl - beta-alanine dipeptide (a "universal hydrophilizer") or allylic hydroxylation in photosensitive rhodamine diazoketones (and spiroamides)...
May 11, 2018: Journal of Organic Chemistry
P Heukels, J A C van Hulst, M van Nimwegen, C E Boorsma, B N Melgert, L M van den Toorn, K A T Boomars, M S Wijsenbeek, H Hoogsteden, J H von der Thüsen, R W Hendriks, M Kool, B van den Blink
BACKGROUND: Fibrocytes are implicated in Idiopathic Pulmonary Fibrosis (IPF) pathogenesis and increased proportions in the circulation are associated with poor prognosis. Upon tissue injury, fibrocytes migrate to the affected organ. In IPF patients, circulating fibrocytes are increased especially during exacerbations, however fibrocytes in the lungs have not been examined. Therefore, we sought to evaluate if fibrocytes can be detected in IPF lungs and we compare percentages and phenotypic characteristics of lung fibrocytes with circulating fibrocytes in IPF...
May 10, 2018: Respiratory Research
Kevin Dent, Geoff G Cole
No abstract text is available yet for this article.
January 1, 2018: Quarterly Journal of Experimental Psychology: QJEP
Dawei Shen, Dominique T Vuvan, Claude Alain
Attentional blink (AB) refers to the situation where correctly identifying a target impairs the processing of a subsequent probe in a sequence of stimuli. Although the AB often coincides with a modulation of scalp-recorded cognitive event-related potentials (ERPs), the neural sources of this effect remain unclear. In two separate experiments, we used Classical LORETA Analysis Recursively Applied (CLARA) to estimate the neural sources of ERPs elicited by an auditory probe when it immediately followed an auditory target (i...
May 9, 2018: Journal of Neurophysiology
James Wolffsohn, Lee Hall, Graeme Young
PURPOSE: To compare the clinical performance of large diameter lenses with optimally fit lenses in the same material and monocurve back surface design. METHOD: In a four-visit, randomised, bilateral, crossover, study, 25 myopic subjects wore optimum diameter lenses (control) and large diameter lenses (test) in random succession for 1 week each. Both study lenses were made of methafilcon A and of an identical design. Trial fittings with Frequency 55 (Coopervision) lenses modified with a design algorithm were used to determine the appropriate custom-made study lenses...
May 5, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
Julián Espinosa, Begoña Domenech, Carmen Vázquez, Jorge Pérez, David Mas
The evaluation of eye blinking has been used for the diagnosis of neurological disorders and fatigue. Despite the extensive literature, no objective method has been found to analyze its kinematic and dynamic behavior. A non-contact technique based on the high-speed recording of the light reflected by the eyelid in the blinking process and the off-line processing of the sequence is presented. It allows for objectively determining the start and end of a blink, besides obtaining different physical magnitudes: position, speed, eyelid acceleration as well as the power, work and mechanical impulse developed by the muscles involved in the physiological process...
2018: PloS One
Maria Miura-Karasawa, Hiroshi Toshida, Toshihiko Ohta, Akira Murakami
Objective: To report a case of coincidence of sebaceous gland hyperplasia and papilloma with detection of human papillomavirus-51 in the apical portion by in situ hybridization. Case presentation: A 75-year-old man noted discomfort at the inner canthus of his left eye when he blinked. A tumor of the lacrimal caruncle was identified and resected. The base of the tumor had a smooth surface and was whitish. In addition, a "navel-like structure" was seen, and the findings strongly suggested sebaceous gland hyperplasia of the lacrimal caruncle...
2018: International Medical Case Reports Journal
Atser Damsma, Robbert van der Mijn, Hedderik van Rijn
In contrast to the paradigms used in most laboratory experiments on interval timing, everyday tasks often involve tracking multiple, concurrent intervals without an explicit starting signal. As these characteristics are problematic for most existing clock-based models of interval timing, here we explore an alternative notion that suggests that time perception and working memory encoding might be closely connected. In this integrative model, the consolidation of a new item in working memory initiates cortical oscillations that also signal the onset of a time interval...
May 3, 2018: Neuropsychologia
Marci L DeRamus, Timothy W Kraft
A visual response to flickering light requires complex retinal computation, and thus ERG measures are an excellent test of retinal circuit fidelity. Critical flicker frequency (CFF) is the frequency at which the retinal response is no longer modulated. Traditionally, CFF is obtained with a series of steady flicker stimuli with increasing frequencies. However, this method is slow and susceptible to experimental drift and/or adaptational effects. The current study compares the steady flicker method to CFF measurements obtained using a frequency sweep protocol...
2018: Advances in Experimental Medicine and Biology
Kelvin Chung, Yu H Leung, Chap H To, Aleksandra B Djurišić, Snjezana Tomljenovic-Hanic
Fluorescence properties of crystallographic point defects within different morphologies of titanium dioxide were investigated. For the first time, room-temperature single-photon emission in titanium dioxide optical defects was discovered in thin films and commercial nanoparticles. Three-level defects were identified because the g (2) correlation data featured prominent shoulders around the antibunching dip. Stable and blinking photodynamics were observed for the single-photon emitters. These results reveal a new room-temperature single-photon source within a wide bandgap semiconductor...
2018: Beilstein Journal of Nanotechnology
Ulrike Hampel, Fabian Garreis, Fabian Burgemeister, Nicole Eßel, Friedrich Paulsen
PURPOSE: The aim of this study was to establish and to evaluate an in vitro model for culturing human telomerase-immortalized corneal epithelial (hTCEpi) cells under adjustable medium flow mimicking the movements of the tear film on the ocular surface. METHODS: Using an IBIDI pump system, cells were cultured under unidirectional, continuous or oscillating, discontinuous medium flow. Cell surface and cytoskeletal architecture were investigated by scanning electron microscopy and immunofluorescence...
April 27, 2018: Ocular Surface
Oya Öztürk, Ayşegül Gündüz, Meral E Kızıltan
OBJECTIVE: In healthy subjects, magnitude of hand-evoked blink reflex (BR) is increased if the stimulated hand is positioned in the peripersonal space. Here, we aimed to investigate the modulation of hand-evoked BR in peripersonal space to understand alterations of cortical modulations of subcortical structures in cervical dystonia. PATIENTS AND METHOD: We recruited 23 patients with idiopathic cervical dystonia and 21 healthy subjects, all of whom had hand-evoked BR...
April 25, 2018: Neuroscience Letters
I-Hsin Ma, Bo-I Kuo, Yu-Chih Hou
PURPOSE: To present recurrent corneal erosion (RCE) caused by late suture exposure after blepharoplasty. METHODS: Four patients who have unilateral RCE were found to have previous blepharoplasty. The RCE was associated with late suture exposure. The clinical courses, characteristics, methods to identify the suture exposure and treatment were presented. RESULTS: The clinical presentations including local erosion of upper bulbar conjunctiva, corneal abrasion lines, local corneal epithelial defects with rough border, and subepithelial opacity were noticed in all four patients...
April 27, 2018: International Ophthalmology
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