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https://www.readbyqxmd.com/read/28937699/electron-transfer-dynamics-from-single-near-infrared-emitting-lead-sulfide-cadmium-sulfide-nanocrystals-to-titanium-dioxide
#1
Huidong Zang, Prahlad K Routh, Qingping Meng, Mircea Cotlet
In this study we report the first successful demonstration of electron transfer between single near infrared emitting PbS/CdS nanocrystals and an external acceptor, titanium dioxide (TiO2). We demonstrate distance-dependent electron transfer from single nanocrystals to TiO2 and explore the effect of this process on the photoluminescence dynamics of these nanocrystals. Isolated PbS/CdS QDs are found to exhibit blinking dynamics similar to other nanocrystals like CdSe/ZnS; however, their photoluminescence follows a quasi two-state pattern with heterogeneous photoluminescence lifetimes which may be the result of their emission originating from different energy states...
September 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/28935579/mechanisms-imaging-and-structure-of-tear-film-breakup
#2
REVIEW
P Ewen King-Smith, Carolyn G Begley, Richard J Braun
Tear film breakup (BU) is an important aspect of dry eye disease, as a cause of ocular aberrations, irritation and ocular surface inflammation and disorder. Additionally, measurement of breakup time, BUT, is a common clinical test for dry eye. The current definition of BUT is subjective; here, a more objective concept of "touchdown" - the moment when the lipid layer touches down on the corneal surface - is proposed as an aid to understanding processes in early and late stages of BU development. Models of BU have generally been based on the assumption that a single mechanism is involved...
September 18, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28929131/spontaneous-eye-blink-rate-ebr-is-uncorrelated-with-dopamine-d2-receptor-availability-and-unmodulated-by-dopamine-agonism-in-healthy-adults
#3
Linh C Dang, Gregory R Samanez-Larkin, Jaime J Castrellon, Scott F Perkins, Ronald L Cowan, Paul A Newhouse, David H Zald
Spontaneous eye blink rate (EBR) has been proposed as a noninvasive, inexpensive marker of dopamine functioning. Support for a relation between EBR and dopamine function comes from observations that EBR is altered in populations with dopamine dysfunction and EBR changes under a dopaminergic manipulation. However, the evidence across the literature is inconsistent and incomplete. A direct correlation between EBR and dopamine function has so far been observed only in nonhuman animals. Given significant interest in using EBR as a proxy for dopamine function, this study aimed to verify a direct association in healthy, human adults...
September 2017: ENeuro
https://www.readbyqxmd.com/read/28925372/an-automatic-algorithm-for-blink-artifact-suppression-based-on-iterative-template-matching-application-to-single-channel-recording-of-cortical-auditory-evoked-potentials
#4
Joaquin T Valderrama, Angel de la Torre, Bram Van Dun
Artifact reduction in electroencephalogram (EEG) signals is usually necessary to carry out data analysis appropriately. Despite the large amount of denoising techniques available with a multichannel setup, there is a lack of efficient algorithms that remove (not only detect) blink-artifacts from a single channel EEG, which is of interest in many clinical and research applications. This paper describes and evaluates the Iterative Template Matching and Suppression (ITMS), a new method proposed for detecting and suppressing the artifact associated with the blink activity from a single channel EEG...
September 19, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28924663/quantitative-single-molecule-localization-microscopy-qsmlm-of-membrane-proteins-based-on-kinetic-analysis-of-fluorophore-blinking-cycles
#5
Franziska Fricke, Joel Beaudouin, Sebastian Malkusch, Roland Eils, Mike Heilemann
Photoswitchable or photoactivatable fluorophores are the key in single-molecule localization microscopy. Next to providing fluorescence images with subdiffraction spatial resolution, additional information is available from observing single fluorophores over time. This includes the characteristic photophysical phenomenon of "blinking" that is exhibited by single fluorescent proteins or fluorophores and follows well-defined kinetic laws. Analyzing the kinetics of "blinking" allows determining the number of fluorophores in a multi-molecular complex...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28919238/post-blink-tear-film-dynamics-in-healthy-and-dry-eyes-during-spontaneous-blinking
#6
Dorota Szczesna-Iskander
PURPOSE: The aim was to investigate the dynamics of post-blink tear film leveling in natural blinking conditions (NBC) for healthy subjects and those diagnosed with dry eye syndrome (DES) and to relate this phase to the tear film surface quality (TFSQ) before the following blink. METHODS: The study included 19 healthy persons and 10 with dry eye, grouped according to symptoms and signs observed during examination. Lateral shearing interferometry was used to examine TFSQ...
September 14, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28913308/new-treatment-in-facial-nerve-palsy-caused-by-sagittal-split-ramus-osteotomy-of-mandible
#7
Jin Hoon Lee, Kyung Ah Lee
A 25-years-old woman with mandibular prognathism underwent a mandibular setback by way of mandibular sagittal split ramus osteotomy (MSSRO). After 2 days of operation, she developed difficulty of closing her right eye. The blink reflex test and motor nerve conduction study of the right orbicularis oris muscle were revealed right facial neuropathy of unknown origin and House-Brackmann facial nerve grading system (HBFNGS) grade V. For treatment, we initially prescribed oral prednisolone and nimodipine including physical therapy...
March 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28895398/nearly-blinking-free-high-purity-single-photon-emission-by-colloidal-inp-znse-quantum-dots
#8
Vigneshwaran Chandrasekaran, Mickaël D Tessier, Dorian Dupont, Pieter Geiregat, Zeger Hens, Edouard Brainis
Colloidal core/shell InP/ZnSe quantum dots (QDs), recently produced using an improved synthesis method, have a great potential in life-science applications as well as in integrated quantum photonics and quantum information processing as single-photon emitters. Single-particle spectroscopy of 10 nm QDs with 3.2 nm cores reveals strong photon antibunching attributed to fast (70 ps) Auger recombination of multiple excitons. The QDs exhibit very good photostability under strong optical excitation. We demonstrate that the antibunching is preserved when the QDs are excited above the saturation intensity of the fundamental-exciton transition...
September 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/28894829/the-effect-of-n-acetyl-cysteine-on-recovery-of-the-facial-nerve-after-crush-injury
#9
Andrew Rivera, Mallory Raymond, Ariel Grobman, Marianne Abouyared, Simon I Angeli
OBJECTIVE: Facial nerve dysfunction can vary in severity and recovery is dependent on the character of the injury. N-acetyl-cysteine prevents oxidative stress and cellular damage, and its use in the setting of nerve dysfunction from crush injury has not yet been established. In this study, rats with facial nerve crush injury will be treated with n-acetyl-cysteine or control and functional recovery and electrophysiologic outcome will be compared. STUDY DESIGN: Prospective, randomized animal study...
June 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28893588/resting-state-fmri-observations-of-baseline-brain-functional-activities-and-connectivities-in-primary-blepharospasm
#10
Ming-Fei Ni, Xiao-Feng Huang, Yan-Wei Miao, Zhan-Hua Liang
Primary blepharospasm (BPS) is a focal dystonia characterized by involuntary eyelid spasms and blinking. The pathophysiology of BPS remains unclear. Several functional and structural neuroimaging studies have demonstrated abnormalities of sensorimotor structures such as the sensorimotor cortex, the basal ganglia, the thalamus and the cerebellum in BPS patients. However, some of the results of these studies were inconsistent. In addition, the relationship between the motor and sensory structures in patients with BPS still needs to be investigated...
September 8, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28893553/caffeine-has-no-effect-on-eyeblink-conditioning-in-mice
#11
Anders Rasmussen, Anna C H G Ijpelaar, Chris I De Zeeuw, Henk-Jan Boele
Caffeine is one of the most widely used drugs in the world. In the brain, caffeine acts as an antagonist for the adenosine A1 and A2B receptors. Since A1 receptors are highly concentrated in the cortex of the cerebellum, we hypothesized that caffeine could potentially affect learning tasks that require the cerebellar cortex, such as eyeblink conditioning. To test this hypothesis, we examined the effect of low (5mg/kg) and high (50mg/kg) doses of caffeine, injected intraperitoneally before training, on eyeblink conditioning in mice...
September 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28892950/riley-day-syndrome-in-a-hispanic-infant-of-non-jewish-ashkenazi-descent
#12
Abel Ramírez-Estudillo, Gerardo González-Saldivar, Itzel Espinosa-Soto, Jesús González-Cortez, Alejandro Salcido-Montenegro
Riley-Day syndrome is an autosomal recessive sensory and autonomic neuropathy. Patients present a lack of fungiform papilla, alacrima and usually feeding difficulties. It is present almost exclusively in Ashkenazi Jewish individuals and has a poor prognosis. We describe an unusual case of Riley-Day syndrome with pseudostrabismus in a non-Ashkenazi Jewish patient. A one-year-old female infant was referred for evaluation of strabismus, absence of fungiform papillae, feeding difficulty, gastroesophageal reflux and episodes of self-mutilation...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28891467/removal-of-inhibition-uncovers-latent-movement-potential-during-preparation
#13
Uday K Jagadisan, Neeraj J Gandhi
The motor system prepares for movements well in advance of their execution. In the gaze control system, the dynamics of preparatory neural activity have been well described by stochastic accumulation-to-threshold models. However, it is unclear whether this activity has features indicative of a hidden movement command. We explicitly tested whether preparatory neural activity in premotor neurons of the primate superior colliculus has "motor potential". We removed downstream inhibition on the saccadic system using the trigeminal blink reflex, triggering saccades at earlier-than-normal latencies...
September 11, 2017: ELife
https://www.readbyqxmd.com/read/28890182/transient-heart-rate-acceleration-in-association-with-spontaneous-eyeblinks
#14
Tamami Nakano, Chiho Kuriyama
The reason why people spontaneously blink several times more frequently than is necessary for ocular lubrication has been a mystery. However, spontaneous eyeblinks selectively occur at attentional breakpoints of information processing, suggesting the involvement of spontaneous eyeblink in attentional disengagement from external stimuli. Physiological activity also changes considerably according to attention state. Heart rate decreases when attention is directed at stimuli, while it increases as attention is released...
September 7, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28888467/early-electrophysiological-findings-in-fisher-bickerstaff-syndrome
#15
M A Alberti, M Povedano, J Montero, C Casasnovas
INTRODUCTION: The term Fisher-Bickerstaff syndrome (FBS) has been proposed to describe the clinical spectrum encompassing Miller-Fisher syndrome (MFS) and Bickerstaff brainstem encephalitis. The pathophysiology of FBS and the nature of the underlying neuropathy (demyelinating or axonal) are still subject to debate. This study describes the main findings of an early neurophysiological study on 12 patients diagnosed with FBS. PATIENTS AND METHODS: Retrospective evaluation of clinical characteristics and electrophysiological findings of 12 patients with FBS seen in our neurology department within 10 days of disease onset...
September 6, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28887471/spatially-encoded-fast-single-molecule-fluorescence-spectroscopy-with-full-field-of-view
#16
Jialei Tang, Yangyang Sun, Shuo Pang, Kyu Young Han
We report a simple single-molecule fluorescence imaging method that increases the temporal resolution of any type of array detector by >5-fold with full field-of-view. We spread single-molecule spots to adjacent pixels by rotating a mirror in the detection path during the exposure time of a single frame, which encodes temporal information into the spatial domain. Our approach allowed us to monitor fast blinking of an organic dye, the dissociation kinetics of very short DNA and conformational changes of biomolecules with much improved temporal resolution than the conventional method...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28886090/relation-of-accommodative-microfluctuation-with-dry-eye-symptoms-in-short-tear-break-up-time-dry-eye
#17
Minako Kaido, Motoko Kawashima, Yuta Shigeno, Yoshiaki Yamada, Kazuo Tsubota
PURPOSE: To investigate accommodative microfluctuations (AMFs) and visual function in short tear break-up time (BUT)-type dry eye (DE) and non-DE subjects. METHODS: This prospective comparative study included 48 volunteers with DE symptoms (mean age 34.8 ± 5.5 years, age range 25-42 years) and 73 without DE symptoms (mean age 30.6 ± 4.7 years, age range 25-42 years). The eyes were divided into two groups: (1) DE group with DE symptoms and BUT ≤ 5 s and (2) non-DE group without DE symptoms and BUT > 5 s...
2017: PloS One
https://www.readbyqxmd.com/read/28886085/meibomian-gland-features-in-a-norwegian-cohort-of-patients-with-primary-sj%C3%A3-gren%C3%A2-s-syndrome
#18
Xiangjun Chen, Øygunn Aass Utheim, Jiaxin Xiao, Muhammed Yasin Adil, Aleksandar Stojanovic, Behzod Tashbayev, Janicke Liaaen Jensen, Tor Paaske Utheim
PURPOSE: To assess the tear film and meibomian gland (MG) features in a Norwegian cohort of patients with primary Sjögren´s syndrome (pSS) and in age- and gender-matched control subjects. METHODS: Thirty-four female patients with pSS (age 52.9±11.9 years) and 32 female control subjects (age 49.0±11.5 years) were recruited. After completion of Ocular Surface Disease Index (OSDI) questionnaire and McMonnies Dry Eye Questionaire, participants underwent measurements of tear osmolarity, tear break-up time (TBUT), ocular surface and corneal staining, Schirmer I test, corneal sensitivity, MG expressibility evaluations, and lid margin morphology examination using slitlamp microscopy...
2017: PloS One
https://www.readbyqxmd.com/read/28871786/fast-background-free-dna-paint-imaging-using-fret-based-probes
#19
Alexander Auer, Maximilian Thomas Strauss, Thomas Schlichthaerle, Ralf Jungmann
DNA points accumulation in nanoscale topography (DNA-PAINT) enables super-resolution microscopy by harnessing the predictable, transient hybridization between short dye-labeled 'imager' and complementary target-bound 'docking' strands. DNA-PAINT microscopy allows sub-5-nm spatial resolution, spectrally unlimited multiplexing and quantitative image analysis. However, these abilities come at the cost of non-fluorogenic imager strands, also emitting fluorescence when not bound to their docking strands. This has thus far prevented rapid image acquisition with DNA-PAINT, as the blinking rate of probes is limited by an upper-bound of imager strand concentrations, which in turn is dictated by the necessity to facilitate detection of single-molecule binding events over the background of unbound, freely diffusion probes...
September 5, 2017: Nano Letters
https://www.readbyqxmd.com/read/28870569/measurement-of-spontaneous-blinks-in-patients-with-parkinson-s-disease-using-a-new-high-speed-blink-analysis-system
#20
Naoko Kimura, Akihide Watanabe, Kazutaka Suzuki, Haruyoshi Toyoda, Naotoshi Hakamata, Hideki Fukuoka, Yukihiko Washimi, Yutaka Arahata, Akinori Takeda, Masaki Kondo, Toshiki Mizuno, Shigeru Kinoshita
INTRODUCTION: Parkinson's disease (PD) patients often have a blinking abnormality. In this study, we examined the kinematic features of spontaneous blinking in 65 PD patients and 62 healthy controls by a new research method utilizing an intelligent vision sensor camera prototype with a 1kHz sampling rate. METHODS: Spontaneous blinks were measured by use of a non-stress 'intelligent vision sensor' camera prototype. RESULTS: The mean spontaneous blink rate was 17...
September 15, 2017: Journal of the Neurological Sciences
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