keyword
https://read.qxmd.com/read/38546503/efficacy-of-aspiration-assisted-ureteral-access-sheath-clearpetra-in-retrograde-intrarenal-surgery
#1
JOURNAL ARTICLE
Mustafa Erkoc, Muammer Bozkurt, Mehmet Ali Sezgin, Levent Ozcan, Osman Can, Eyyüp Danis, Emre Can Polat, Alper Otunctemur
Backgrounds: In the renal intrarenal stone surgery (RIRS) procedure, ureteral access sheath (UAS) is still used in the majority of surgeries to both protect the flexible ureteroscope (FURS) and reduce intrarenal pressure. ClearPETRA is a new UAS that has an integrated aspiration port. We aimed to evaluate the clinical outcomes and effectiveness of Aspiration-Assisted UAS (ClearPETRA) in the RIRS procedure. Methods: One thousand six hundred twenty patients who underwent RIRS between January 2021 and January 2024 were evaluated retrospectively and 512 patients were included in the study...
March 28, 2024: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://read.qxmd.com/read/38540754/limonene-exerts-anti-inflammatory-effect-on-lps-induced-jejunal-injury-in-mice-by-inhibiting-nf-%C3%AE%C2%BAb-ap-1-pathway
#2
JOURNAL ARTICLE
Sarmed H Kathem, Yasameen Sh Nasrawi, Shihab H Mutlag, Surya M Nauli
The human gastrointestinal system is a complex ecosystem crucial for well-being. During sepsis-induced gut injury, the integrity of the intestinal barrier can be compromised. Lipopolysaccharide (LPS), an endotoxin from Gram-negative bacteria, disrupts the intestinal barrier, contributing to inflammation and various dysfunctions. The current study explores the protective effects of limonene, a natural compound with diverse biological properties, against LPS-induced jejunal injury in mice. Oral administration of limonene at dosages of 100 and 200 mg/kg was used in the LPS mouse model...
March 12, 2024: Biomolecules
https://read.qxmd.com/read/38540188/in-vitro-simulated-hemoperfusion-on-seraph-%C3%A2-100-as-a-promising-strategy-to-counteract-sepsis
#3
JOURNAL ARTICLE
Antonio Lacquaniti, Antonella Smeriglio, Susanna Campo, Erminia La Camera, Giovanni Lanteri, Elena Giunta, Paolo Monardo, Domenico Trombetta
Blood purification represents a treatment option for sepsis, improving inflammation and the hyper-activated immune system. This study investigates the binding efficacy of Seraph® -100 against 108 CFU/mL of Staphylococcus aureus ( S. aureus ), Pseudomonas aeruginosa ( P. aeruginosa ), and Escherichia coli ( E. coli ) during a simulated hemoperfusion treatment. The fluorescence-activated cell sorting (FACS) technique was used to evaluate the bacteria reduction, whereas kinetic analysis and cultures revealed bacterial detection and counting at established time points...
March 5, 2024: Biomedicines
https://read.qxmd.com/read/38534689/daptomycin-use-for-persistent-coagulase-negative-staphylococcal-bacteremia-in-a-neonatal-intensive-care-unit
#4
JOURNAL ARTICLE
Eleni Papachatzi, Despoina Gkentzi, Sotiris Tzifas, Theodore Dassios, Gabriel Dimitriou
During the last two decades, the incidence of late-onset sepsis (LOS) has increased due to improved survival of premature neonates. Persistent bacteremia (PB) in LOS is defined as more than two positive blood cultures obtained on different calendar days during the same infectious episode. Although rare, PB should be treated aggressively to prevent adverse outcomes. Daptomycin, a lipopeptide antibiotic, has been used in neonates with persistent coagulase-negative staphylococci (CoNS) bacteremia with promising results, but studies reporting on the efficacy and safety of the agent are scarce...
March 12, 2024: Antibiotics
https://read.qxmd.com/read/38529931/acute-kidney-injury-in-children-with-lymphoma
#5
JOURNAL ARTICLE
Hejia Zhang, Yanlong Duan, Xiaoxue Li, Zhi Chen, Xiaorong Liu
OBJECTIVE: To analyze the epidemiology of acute kidney injury (AKI) in children with lymphoma and to assess the incidence, risk profile of AKI, and effects on renal function in children with lymphoma during their first 30 days of hospitalization. MATERIALS AND METHODS: This was a retrospective screen of electronic hospital and laboratory databases to select hospitalized children who were first diagnosed and treated for lymphoma at Beijing Children's Hospital between 2020 and 2021...
March 26, 2024: Clinical Nephrology
https://read.qxmd.com/read/38529436/penile-calciphylaxis-a-successfully-treated-case
#6
Narine Misakyan, Amer Abu-Shanab, Shazia Shah
Penile calciphylaxis is a rare presentation of calcific uremic arteriolopathy and can be a life-threatening condition usually seen in patients with end-stage renal failure with hemodialysis. The clear etiopathogenesis of calciphylaxis is not fully understood, but it is postulated to be characterized by the accumulation of calcium in the microvessels of adipose tissue and skin, which leads to ischemia and necrosis, causing painful ulcerations, and could potentially be complicated by sepsis and mortality...
February 2024: Curēus
https://read.qxmd.com/read/38528210/colonoscopy-utilization-in-elderly-patients-with-dementia-characteristics-complications-and-charges-in-a-national-matched-cohort-analysis
#7
JOURNAL ARTICLE
Faris Shweikeh, Gordon Hong, Kathleen Rogers, Mohamad Mouchli, Matthew Hoscheit, Anthony Lembo
BACKGROUND: It is projected that the elderly population will continue to increase. Many will develop chronic conditions such as dementia. AIMS: Our aims are to describe the utilization of colonoscopy among patients with dementia and compare outcomes in those with and without dementia. METHODS: This population-based analysis utilized the National Inpatient Sample (NIS) during 2019. Patients with dementia over the age of 60 years receiving colonoscopy were identified utilizing ICD-10 codes...
March 25, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38524548/sequential-respiratory-support-in-septic-patients-undergoing-continuous-renal-replacement-therapy-a-study-based-on-mimic-iii-database
#8
JOURNAL ARTICLE
Chunxia Wang, Jianli Zheng, Yilin Zhao, Tiantian Liu, Yucai Zhang
OBJECTIVE: Oxygen and hemodynamic management are important for providing a sufficient adequate oxygen-containing blood to the organs for septic patients. In present study, we aimed to explore the application of sequential respiratory support (SRS) and the association of SRS with the outcome of septic patients who needed continuous renal replacement therapy (CRRT). METHODS: We extracted the medical information of septic patients who received CRRT within 24 h of intensive care unit (ICU) admission from the MIMIC-III v1...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38522861/successful-treatment-of-generalized-pustular-psoriasis-with-guselkumab
#9
JOURNAL ARTICLE
Martina Part
The purpose of the article: Generalized pustular psoriasis (GPP) is a rare auto-inflammatory disease. Patients with GPP may develop life-threatening complications, including sepsis, acute renal failure, neutrophilic cholangitis, high-output congestive heart failure, acute respiratory distress syndrome and death. The therapy of GPP is very limited and the course of the disease is unpredictable. Materials and methods: We report a 60-year-old woman presenting with widespread and confluent erythematous-desquamative plaques with numerous small pustules covering almost 70% of the body surface area...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38517232/development-and-validation-of-a-nomogram-for-predicting-28-day-in-hospital-mortality-in-sepsis-patients-based-on-an-optimized-apache-ii-score
#10
JOURNAL ARTICLE
Yamin Yuan, Yanfei Meng, Yihui Li, Jinquan Zhou, Jiaqi Wang, Yujing Jiang, Li Ma
PURPOSE: The objective of this study is to establish a nomogram that correlates optimized APACHE II score with sepsis-related indicators, aiming to provide a robust model for early prediction of sepsis prognosis in clinical practice and serve as a valuable reference for improved diagnosis and treatment strategies. METHODS: This retrospective study extracted sepsis patients meeting the inclusion criteria from the MIMIC-IV database to form the training group. An optimized Acute Physiology and Chronic Health Evaluation (APACHE) II score integrated with relevant indicators was developed using a nomogram for predicting the prognosis of sepsis patients...
February 5, 2024: Shock
https://read.qxmd.com/read/38516467/mortality-analysis-in-geriatric-patients-with-acute-kidney-injury-admitted-in-the-intensive-care-unit-a-single-center-cross-sectional-study
#11
JOURNAL ARTICLE
Girish V Kumthekar, Veena Purandare, Manasi Nagarkar, Shruti Paramshetti
Introduction Acute kidney injury (AKI) is an abrupt reduction in kidney function that causes nitrogenous waste and other waste products to be retained. Methods This cross-sectional study was conducted from February 2015 to January 2016. The study received approval from the Independent Ethics Committee, which included patients over 60 with AKI. The study duration was 12 consecutive months to ascertain the etiology, severity, and hospital outcomes of AKI. Results The common etiologies of AKI included drug-induced (25%), age-related (21...
February 2024: Curēus
https://read.qxmd.com/read/38515313/the-effect-of-thyme-essential-oil-and-endothelial-progenitor-stem-cells-on-lipopolysaccharide-induced-sepsis-in-c57bl-6-mice
#12
JOURNAL ARTICLE
Mohammad Mehdi Soltan Dallal, Maryam Siavashi, Samira Karimaei, Vahid Siavashi, Milad Abdi, Mehdi Yaseri, Seyed Alireza Razavi, Ronak Bakhtiari
Sepsis is a potentially fatal syndrome related to severe systemic inflammation developed by infection. Despite different antimicrobial therapies, morbidity and mortality rates remain high. Herbs along with cell therapy have been introduced as a promising option to improve the symptoms of sepsis. The present study aimed to evaluate the therapeutic effect of simultaneous administration of thyme essential oil (TEO) and endothelial progenitor stem cells (EPCs) on lipopolysaccharide (LPS)-induced sepsis in C57BL/6 mice...
March 21, 2024: Biotechnology and Applied Biochemistry
https://read.qxmd.com/read/38515158/acetyl-coa-synthetase-2-induces-pyroptosis-and-inflammation-of-renal-epithelial-tubular-cells-in-sepsis-induced-acute-kidney-injury-by-upregulating-the-klf5-nf-%C3%AE%C2%BAb-pathway
#13
JOURNAL ARTICLE
Jian Lu, Ya Hou, Si-Xiu Liu, Bo Jin, Jing Liu, Nan Li, Yan Zhu, Qing-Yan Zhang, Cheng Wan, Yuan Feng, Jun Xie, Chun-Ming Jiang
BACKGROUND: Pyroptosis of the renal tubular epithelial cells (RTECs) and interstitial inflammation are central pathological characteristics of acute kidney injury (AKI). Pyroptosis acts as a pro-inflammatory form of programmed cell death and is mainly dependent on activation of the NLRP3 inflammasome. Previous studies revealed that acetyl-CoA synthetase 2 (ACSS2) promotes inflammation during metabolic stress suggesting that ACSS2 might regulate pyroptosis and inflammatory responses of RTECs in AKI...
March 21, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38513598/dexmedetomidine-attenuates-lipopolysaccharide-induced-renal-cell-fibrotic-phenotypic-changes-by-inhibiting-necroinflammation-via-activating-%C3%AE-2-adrenoceptor-a-combined-randomised-animal-and-in-vitro-study
#14
JOURNAL ARTICLE
Qizhe Sun, Priyanka Kamath, Yibing Sun, Min Liang, Lingzhi Wu, Enqiang Chang, Qian Chen, Azeem Alam, Yi Liu, Hailin Zhao, Daqing Ma
BACKGROUND: Acute kidney injury (AKI) was reported to be one of the initiators of chronic kidney disease (CKD) development. Necroinflammation may contribute to the progression from AKI to CKD. Dexmedetomidine (Dex), a highly selective α2 -adrenoreceptor (AR) agonist, has cytoprotective and "anti-" inflammation effects. This study was designed to investigate the anti-fibrotic properties of Dex in sepsis models. METHODS: C57BL/6 mice were randomly treated with an i...
March 19, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38512920/mortality-in-patients-with-normal-left-ventricular-function-requiring-emergency-va-ecmo-for-postcardiotomy-cardiogenic-shock-due-to-coronary-malperfusion
#15
JOURNAL ARTICLE
Jagdip Kang, Mateo Marin-Cuartas, Anna Flo Forner, Priya R Menon, André Ginther, Diyar Saaed, Suzanne de Waha, Massimiliano Meineri, Jörg Ender, Michael A Borger
OBJECTIVES: To analyze outcomes in patients with normal preoperative left ventricular ejection fraction (LVEF) undergoing venoarterial extracorporeal membrane oxygenation (VA-ECMO) therapy due to postcardiotomy cardiogenic shock (PCCS) related to coronary malperfusion. METHODS: Retrospective single-center analysis in patients with normal preoperative LVEF treated with VA-ECMO for coronary malperfusion-related PCCS between May 1998 and May 2018. The primary outcome was 30-day mortality, which was compared using the Kaplan-Meier method and the log-rank test...
2024: PloS One
https://read.qxmd.com/read/38510775/the-use-of-sustained-low-efficiency-dialysis-in-the-treatment-of-sepsis-associated-acute-kidney-injury-in-a-low-income-country-a-prospective-cohort-study
#16
JOURNAL ARTICLE
Abdalla Kamal Abdalla Taha, Mazin Mohammed Taha Shigidi, Nazik Mahmoud Abdulfatah, Rajabia Khidir Alsayed
BACKGROUND: Limited data are available regarding the management and outcomes of patients with sepsis-associated acute kidney injury (SA-AKI) requiring dialysis in Sudan. Continuous renal replacement therapy (CRRT) is a highly favored treatment modality in such patients. However, it stays unavailable and expensive treatment in most low-income countries. We aimed to evaluate the use of sustained low-efficiency dialysis (SLED) in the treatment of hemodynamically unstable patients with SA-AKI admitted to the intensive care unit (ICU)...
January 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38510768/is-sled-efficient-in-sepsis-associated-acute-kidney-injury-hope-but-hold
#17
EDITORIAL
Akshaykumar Amarchand Chhallani
How to cite this article: Chhallani AA. Is SLED Efficient in Sepsis Associated Acute Kidney Injury: Hope but Hold!! Indian J Crit Care Med 2024;28(1):5-7.
January 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38509493/analysis-of-the-incidence-and-risk-factors-of-blood-transfusion-in-total-knee-revision-a-retrospective-nationwide-inpatient-sample-database-study
#18
JOURNAL ARTICLE
Xiaoyin Li, Hao Xie, Shuxia Liu, Jian Wang, Zhanjun Shi, Qiaobing Yao, Qinfeng Yang, Qiuhong Li, Liangxiao Bao
OBJECTIVE: This study sought to determine the incidence and risk factors of blood transfusion among patients undergoing total knee revision (TKR) using a nationwide database. METHODS: A retrospective data analysis was conducted based on the Nationwide Inpatient Sample (NIS), enrolling patients who underwent TKR from 2010 to 2019 with complete information. The patients were divided into two groups based on whether they received blood transfusion or not. The demographic characteristics (race, sex, and age), length of stay (LOS), total charge of hospitalization, hospital characteristics (admission type, insurance type, bed size, teaching status, location, and region of hospital), hospital mortality, comorbidities, and perioperative complications were analyzed...
March 20, 2024: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/38505156/the-challenging-management-of-malignant-ureteral-obstruction-analysis-of-a-series-of-188-cases
#19
JOURNAL ARTICLE
Alberto Artiles Medina, Inés Laso García, Fernando González Tello, Sara Álvarez Rodríguez, Manuel Hevia Palacios, Marina Mata Alcaraz, César Mínguez Ojeda, Fernando Arias Funez, Victoria Gómez Dos Santos, Francisco Javier Burgos Revilla
BACKGROUND: Malignant ureteral obstruction (MUO) is a common condition that complicates the course of advanced malignancies. The aims of this study are to analyze the causes, management, and survival of patients with obstructive nephropathy due to malignant ureteric obstruction and to determine prognostic factors. Furthermore, we studied the complications and outcomes in patients who underwent urinary diversion. MATERIALS AND METHODS: A retrospective study was conducted on patients with computed tomography-confirmed MUO between January 2016 and November 2020...
March 2024: Current Urology
https://read.qxmd.com/read/38505014/more-attention-should-be-paid-to-omicron-associated-sepsis-a-multicenter-retrospective-study-in-south-china
#20
JOURNAL ARTICLE
Ling Sang, Yonghao Xu, Yongbo Huang, Zhengtu Li, Deliang Wen, Changbo Liu, Yichun Wang, Lewu Xian, Linling Cheng, Feng Ye, Hongkai Wu, Xilong Deng, Yueping Li, Weiyan Ye, Nanshan Zhong, Yimin Li, Shiyue Li, Xiaoqing Liu
BACKGROUND: The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly transmissible but causes less severe disease compared to other variants. However, its association with sepsis incidence and outcomes is unclear. This study aimed to investigate the incidence of Omicron-associated sepsis, as per the Sepsis 3.0 definition, in hospitalized patients, and to explore its relationship with clinical characteristics and prognosis. METHODS: This multicenter retrospective study included adults hospitalized with confirmed SARS-CoV-2 infection across six tertiary hospitals in Guangzhou, China from November 2022 to January 2023...
February 29, 2024: Journal of Thoracic Disease
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