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Chronic kidney disease immune

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https://www.readbyqxmd.com/read/29910038/idiopathic-nephrotic-syndrome-in-children
#1
REVIEW
Damien G Noone, Kazumoto Iijima, Rulan Parekh
The incidence of idiopathic nephrotic syndrome (NS) is 1·15-16·9 per 100 000 children, varying by ethnicity and region. The cause remains unknown but the pathogenesis of idiopathic NS is thought to involve immune dysregulation, systemic circulating factors, or inherited structural abnormalities of the podocyte. Genetic risk is more commonly described among children with steroid-resistant disease. The mainstay of therapy is prednisone for the vast majority of patients who are steroid responsive; however, the disease can run a frequently relapsing course, necessitating the need for alternative immunosuppressive agents...
June 14, 2018: Lancet
https://www.readbyqxmd.com/read/29904385/dysregulation-of-b-cell-activity-during-proliferative-kidney-disease-in-rainbow-trout
#2
Beatriz Abos, Itziar Estensoro, Pedro Perdiguero, Marc Faber, Yehfang Hu, Patricia Díaz Rosales, Aitor G Granja, Christopher J Secombes, Jason W Holland, Carolina Tafalla
Proliferative kidney disease (PKD) is a widespread disease caused by the endoparasite Tetracapsuloides bryosalmonae (Myxozoa: Malacosporea). Clinical disease, provoked by the proliferation of extrasporogonic parasite stages, is characterized by a chronic kidney pathology with underlying transcriptional changes indicative of altered B cell responses and dysregulated T-helper cell-like activities. Despite the relevance of PKD to European and North American salmonid aquaculture, no studies, to date, have focused on further characterizing the B cell response during the course of this disease...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29888042/somatic-t-cell-receptor-diversity-in-a-chronic-kidney-disease-patientpopulation-linked-to-electronic-health-records
#3
Dana C Crawford, Jessica N Cooke Bailey, Kristy Miskimen, Penelope Miron, Jacob L McCauley, John R Sedor, John F ƠToole, William S Bush
Germline and somatic genomic variation represent the bulk of 'omics data available for precision medicine research. These data, however, may fail to capture the dynamic biological processes that underlie disease development, particularly for chronic diseases of aging such as chronic kidney disease (CKD). To demonstrate the value of additional dynamic precision medicine data, we sequenced somatic T-cell receptor rearrangements, markers of the adaptive immune response, from genomic DNA collected during a clinical encounter from 15 participants with CKD and associated co-morbidities...
2018: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/29887267/-immunizations-for-patients-with-kidney-disease
#4
Claire Trivin-Avillach, Éric Thervet
Chronic kidney disease (CKD) is associated with significant infectious complications leading to adverse health outcomes. This increased susceptibility to infection can be related to the nephropathy itself as observed in nephrotic syndrome, to the treatment especially in situations requiring immunosuppressive drugs or related to dialysis. Despite a less effective response to vaccination, some data emphasize similar benefits from immunization among people with CKD to the general population. However, some situations encountered in nephrology require adaptation of immunization practices...
June 7, 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29887266/intracellular-organelles-in-health-and-kidney-disease
#5
Fateme Shamekhi Amiri
Subcellular organelles consist of smaller substructures called supramolecular assemblies and these in turn consist of macromolecules. Various subcellular organelles have critical functions that consist of genetic disorders of organelle biogenesis and several metabolic disturbances that occur during non-genetic diseases e.g. infection, intoxication and drug treatments. Mitochondrial damage can cause renal dysfunction as ischemic acute renal injury, chronic kidney disease progression. Moreover, mitochondrial dysfunction is an early event in aldosterone-induced podocyte injury and cardiovascular disease due to oxidative stress in chronic kidney disease...
June 7, 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29868892/murine-renal-transcriptome-profiles-upon-leptospiral-infection-implications-for-chronic-kidney-diseases
#6
Li-Fang Chou, Ting-Wen Chen, Huang-Yu Yang, Ming-Yang Chang, Shen-Hsing Hsu, Chung-Ying Tsai, Yi-Ching Ko, Chiung-Tseng Huang, Ya-Chung Tian, Cheng-Chieh Hung, Chih-Wei Yang
Background: Leptospirosis caused by pathogenic Leptospira spp. leads to kidney damage that may progress to chronic kidney disease. However, how leptospiral infections-induced renal damage is unclear. Methods: We apply microarray and RNA-seq technologies to investigate the first murine transcriptome-wide, leptospires-mediated changes in renal gene expression to identify biological pathways associated with kidney damage. Results: Leptospiral genes were detected in renal transcriptomes of mice infected with Leptospira interrogans at day 28 post-infection, suggesting colonization of leptospires within the kidney with propensity of chronicity...
June 2, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29868033/aberrant-t-cell-signaling-and-subsets-in-systemic-lupus-erythematosus
#7
REVIEW
Takayuki Katsuyama, George C Tsokos, Vaishali R Moulton
Systemic lupus erythematosus (SLE) is a chronic multi-organ debilitating autoimmune disease, which mainly afflicts women in the reproductive years. A complex interaction of genetics, environmental factors and hormones result in the breakdown of immune tolerance to "self" leading to damage and destruction of multiple organs, such as the skin, joints, kidneys, heart and brain. Both innate and adaptive immune systems are critically involved in the misguided immune response against self-antigens. Dendritic cells, neutrophils, and innate lymphoid cells are important in initiating antigen presentation and propagating inflammation at lymphoid and peripheral tissue sites...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29843384/alcoholism-a-multi-systemic-cellular-insult-to-organs
#8
REVIEW
Ucee Dguzeh, Natasha C Haddad, Kathia T S Smith, John O Johnson, Angelia A Doye, Judith K Gwathmey, Georges E Haddad
Alcohol abuse can affect more than the heart and the liver. Many observers often do not appreciate the complex and differing aspects of alcohol's effects in pathophysiologies that have been reported in multiple organs. Chronic alcohol abuse is known to be associated with pathophysiological changes that often result in life-threatening clinical outcomes, e.g., breast and colon cancer, pancreatic disease, cirrhosis of the liver, diabetes, osteoporosis, arthritis, kidney disease, immune system dysfunction, hypertension, coronary artery disease, cardiomyopathy, and can be as far-reaching as to cause central nervous system disorders...
May 28, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29808448/transcriptome-analysis-supports-viral-infection-and-fluoride-toxicity-as-contributors-to-chronic-kidney-disease-of-unknown-etiology-ckdu-in-sri-lanka
#9
Saravanabavan Sayanthooran, Lishanthe Gunerathne, Tilak D J Abeysekera, Dhammika N Magana-Arachchi
PURPOSE: Chronic kidney disease of unknown etiology (CKDu), having epidemic characteristics, is being diagnosed increasingly in certain tropical regions of the world, mainly Latin America and Sri Lanka. They have been observed primarily in farming communities and current hypotheses point toward many environmental and occupational triggers. CKDu does not have common etiologies of chronic kidney disease (CKD) such as hypertension, diabetes, or autoimmune disease. We aimed to understand the molecular processes underlying CKDu in Sri Lanka using transcriptome analysis...
May 28, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29797446/immune-cell-trafficking-lymphatics-and-hypertension
#10
REVIEW
Dakshnapriya Balasubbramanian, Catalina A Lopez Gelston, Joseph M Rutkowski, Brett M Mitchell
Activated immune cell infiltration into organs contributes to the development and maintenance of hypertension. Studies targeting specific immune cell populations or reducing their inflammatory signaling have demonstrated a reduction in blood pressure. Lymphatic vessels play a role in immune cell trafficking and resolving inflammation, but little is known about their role in hypertension. Studies from our laboratory and others suggest that inflammation-associated or induction of lymphangiogenesis is organ protective and anti-hypertensive...
May 24, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29768353/correlation-of-increased-th17-treg-cell-ratio-with-endoplasmic-reticulum-stress-in-chronic-kidney-disease
#11
Xiaojing Zhu, Shuiqin Li, Qiaona Zhang, Dan Zhu, Yang Xu, Pengqian Zhang, Jin Han, Zhaoyang Duan, Jie Gao, Yan Ou
To investigate the relationship between the regulatory immune network and endoplasmic reticulum stress (ERS) in patients with different stages of chronic kidney disease (CKD).A total of 91 patients diagnosed with CKD were divided into different groups according to the stage of disease and treatment with hemodialysis (HD) or peritoneal dialysis (PD). Routine blood and biochemical tests were performed in patients in the different CKD groups and in healthy controls (n = 20). The frequencies of T helper type 17 (Th17) and regulatory T (Treg) cells in the overall T cell population were measured by flow cytometric analysis...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29760448/the-gut-microbiota-and-the-brain-gut-kidney-axis-in-hypertension-and-chronic-kidney-disease
#12
REVIEW
Tao Yang, Elaine M Richards, Carl J Pepine, Mohan K Raizada
Crosstalk between the gut microbiota and the host has attracted considerable attention owing to its involvement in diverse diseases. Chronic kidney disease (CKD) is commonly associated with hypertension and is characterized by immune dysregulation, metabolic disorder and sympathetic activation, which are all linked to gut dysbiosis and altered host-microbiota crosstalk. In this Review, we discuss the complex interplay between the brain, the gut, the microbiota and the kidney in CKD and hypertension and explain our brain-gut-kidney axis hypothesis for the pathogenesis of these diseases...
May 14, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29745904/structural-analysis-of-a-petri-net-model-of-oxidative-stress-in-atherosclerosis
#13
Adam Kozak, Dorota Formanowicz, Piotr Formanowicz
Atherosclerosis is a complex process of gathering sub-endothelial plaques decreasing lumen of the blood vessels. This disorder affects people of all ages, but its progression is asymptomatic for many years. It is regulated by many typical and atypical factors including the immune system response, a chronic kidney disease, a diet rich in lipids, a local inflammatory process and a local oxidative stress that is here one of the key factors. In this study, a Petri net model of atherosclerosis regulation is presented...
June 2018: IET Systems Biology
https://www.readbyqxmd.com/read/29745362/does-dietary-nitrate-say-no-to-cardiovascular-ageing-current-evidence-and-implications-for-research
#14
Mario Siervo, Filippo Scialò, Oliver M Shannon, Blossom C M Stephan, Ammar W Ashor
CVD are characterised by a multi-factorial pathogenesis. Key pathogenetic steps in the development of CVD are the occurrence of endothelial dysfunction and formation of atherosclerotic lesions. Reduced nitric oxide (NO) bioavailability is a primary event in the initiation of the atherosclerotic cascade. NO is a free radical with multiple physiological functions including the regulation of vascular resistance, coagulation, immunity and oxidative metabolism. The synthesis of NO proceeds via two distinct pathways identified as enzymatic and non-enzymatic...
May 2018: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29742283/vaccination-practices-in-dialysis-patients-a-narrative-review
#15
REVIEW
Georges Kosmadakis, Julie Albaret, Enrique Da Costa Correia, Frederic Somda, Didier Aguilera
In a period of turmoil concerning vaccination practices, there is a serious conflict between scientifically reasonable, evidence-based guidelines and the far-fetched rumors or misconceptions concerning the vaccination practices in the general population. When a significant portion of the medical and paramedical personnel may be deliberately unvaccinated against common biological agents, achieving effective vaccination rates in the dialysis population may be complicated. Vaccination rates are unacceptably low in dialysis patients and seroconversion rates are even lower; further, serological follow-up is generally poor...
May 9, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29742060/renal-involvement-in-autoinflammatory-diseases-and-inflammasome-mediated-chronic-kidney-damage
#16
REVIEW
Roberto Scarpioni, Laura Obici
Unprovoked activation of innate immune pathways and increased secretion of interleukin (IL)-1β and IL-18 are responsible for the protean clinical manifestations and the marked inflammatory response that characterise most hereditary autoinflammatory disorders. The kidney is a major target organ of this inflammatory process. The deposition of the acute-phase reactant serum amyloid A (SAA) as amyloid causes progressive glomerular and vascular damage and leads to organ failure. In this review we focus on the potential impact of hereditary autoinflammatory diseases on renal function, provide red flags that may guide the clinical suspicion of amyloid kidney damage and discuss the relevance of close renal monitoring for early diagnosis and prompt treatment...
January 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29738027/hydralazine-associated-adverse-events-a-report-of-two-cases-of-hydralazine-induced-anca-vasculitis
#17
Roman Zuckerman, Mayurkumar Patel, Eric J Costanzo, Harry Dounis, Rany Al Haj, Seyedehsara Seyedali, Arif Asif
Hydralazine is a direct-acting vasodilator, which has been used in treatment for hypertension (HTN) since the 1950s. While it is well known to cause drug-induced lupus (DIL), recent reports are indicating the emergence of the drug-induced anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (DIV). Herein, we describe two patients (aged 57 and 87 years) who presented with severe acute kidney injury (AKI), proteinuria, and hematuria. Both were receiving hydralazine for the treatment of hypertension...
May 7, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29733407/bone-inflammation-and-the-bone-marrow-niche-in-chronic-kidney-disease-what-do-we-know
#18
Sandro Mazzaferro, Giuseppe Cianciolo, Antonio De Pascalis, Chiara Guglielmo, Pablo A Urena Torres, Jordi Bover, Lida Tartaglione, Marzia Pasquali, Gaetano La Manna
Recent improvements in our understanding of physiology have altered the way in which bone is perceived: no longer is it considered as simply the repository of divalent ions, but rather as a sophisticated endocrine organ with potential extraskeletal effects. Indeed, a number of pathologic conditions involving bone in different ways can now be reconsidered from a bone-centred perspective. For example, in metabolic bone diseases like osteoporosis (OP) and renal osteodystrophy (ROD), the association with a worse cardiovascular outcome can be tentatively explained by the possible derangements of three recently discovered bone hormones (osteocalcin, fibroblast growth factor 23 and sclerostin) and a bone-specific enzyme (alkaline phosphatase)...
May 4, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29730854/renal-involvement-in-antiphospholipid-syndrome
#19
REVIEW
Francisco Vileimar Andrade de Azevedo, Diego Germano Maia, Jozelio Freire de Carvalho, Carlos Ewerton Maia Rodrigues
This is a review of scientific publications on renal involvement in antiphospholipid syndrome (APS), with focus on clinical and histopathological findings and treatment. A search for English-language articles on renal involvement in APS covering the period 1980-2017 was conducted in Medline/PubMed and Scopus databases using the MeSH terms "antiphospholipid syndrome", "antiphospholipid antibodies", "glomerulonephritis" and "thrombotic microangiopathy" (TMA). APS nephropathy is primarily the result of thromboses in renal arteries or veins, intraparenchymatous arteries and glomerular capillaries...
May 5, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29729216/exacta-skeletal-muscle-in-the-fight-against-chronic-diseases
#20
EDITORIAL
Anika Westphal, Ralf Mrowka
The causes for the development of chronic diseases like diabetes, cardiovascular disease or cancer are multifactorial and often influence each other. With increasing age the risk for developing type 2 diabetes increases and the risk to suffer from cardiovascular and chronic kidney disease is increased once a patient is diabetic. Besides pharmacological treatment there is one strategy to combat the development or progress of most chronic disease: physical activity. Research is going on to understand the impact of skeletal muscle and exercise on improving the health status in e...
May 5, 2018: Acta Physiologica
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