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Cecile A Unger, Matthew D Barber, Mark D Walters
OBJECTIVES: The aims of the study were to describe ultrasound findings in women with stress urinary incontinence (SUI) after transurethral injection of Coaptite, to describe symptoms 3 months after injection, and to determine whether there was an association between degree of improvement and sonographic findings. METHODS: This is a prospective cohort study of women with SUI undergoing transurethral Coaptite injection. Subjects completed the Urinary Distress Inventory and Incontinence Severity Index preinjection and 3 months postinjection...
March 2016: Female Pelvic Medicine & Reconstructive Surgery
Tin C Ngo, Ilene Yi-Zhen Wong, William A Kennedy
Purpose. Minimal data exists comparing dextranomer/hyaluronic acid (Dx/HA) and calcium hydroxyapatite (CaHA) for the endoscopic treatment of VUR in the hands of a single user. Materials and Methods. We reviewed our consecutive single-user case series of 27 children (42 ureters) receiving endoscopic treatment with CaHA and 21 children (33 ureters) who received Dx/HA injection. Children receiving CaHA injections were divided into two groups of 13 and 14 patients (Coaptite I and II) to assess the learning curve effects...
2013: Advances in Urology
Z I Hussain, M Lim, S G Stojkovic
BACKGROUND: Injectable bulking agents have been used with varying success for the treatment of faecal incontinence. This systematic review aimed to investigate the various injectable agents and techniques used for the treatment of faecal incontinence, and to assess their safety and efficacy. METHODS: Thirty-nine publications were identified and studied. The following variables were pooled for univariable analysis: type, location, route of bulking agents, and the use of ultrasound guidance, antibiotics, laxatives and anaesthetics...
November 2011: British Journal of Surgery
Murad Alam, Jillian Havey, Natalie Pace, Marisa Pongprutthipan, Simon Yoo
BACKGROUND: Small-particle calcium hydroxylapatite (Radiesse, Merz, Frankfurt, Germany) is safe and effective for facial wrinkle reduction, and has medium-term persistence for this indication. There is patient demand for similar fillers that may be longer lasting. OBJECTIVE: We sought to assess the safety and persistence of effect in vivo associated with use of large-particle calcium hydroxylapatite (Coaptite, Merz) for facial augmentation and wrinkle reduction...
July 2011: Journal of the American Academy of Dermatology
Ayhan Dirim, Huseyin Celik, Eray Hasirci, Cem Aygun, Tahsin Turunc, Hakan Ozkardes, Mehmet Haberal
OBJECTIVES: To evaluate the results of end-stage renal failure in transplanted cases due to vesicoureteral reflux after a subureteric injection of calcium hydroxyapatite (Coaptite). MATERIALS AND METHODS: Twenty-three patients (39 renal units) with end-stage renal failure secondary to vesicoureteral reflux were included. Reflux was bilateral in 16 cases and unilateral in 7 of the cases. There were 3 degrees of reflux according to the distribution of renal units...
March 2010: Experimental and Clinical Transplantation
C Luo, C B Samaranayake, L D Plank, I P Bissett
OBJECTIVE: The aim of this study was to systematically review all published evidence to determine the efficacy and safety of injectable bulking agents for passive faecal incontinence (FI) in adults. METHOD: Electronic searches were performed for MEDLINE, EMBASE, ISI Web of Knowledge and other relevant databases. Hand searching of relevant conference proceedings was undertaken. Studies were considered if they met the predefined inclusion criteria of more than ten adult patients and receiving an injectable bulking agent for passive FI with a validated means of assessing preoperative and postoperative incontinence...
April 2010: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
L Nortes Cano, G Zambudio Carmona, M J Guirao Piñera, J I Ruiz Jiménez
PURPOSE: The primary vesicoureteral reflux (PVUR) is the most common urologic pathology during childhood and affects from 1 to 3% of newborn. It causes acute pyelonephritis (APN) and renal damage in addition to hospital visits with high economic and social costs. Nowadays the endoscopic treatment (ETR) seems to be the most suitable one for the reflux, due to its lower biological cost and its good results. We report our experience in the endoscopic treatment of the primary vesicoureteral reflux (ETR) in Murcia Pediatric Hospital from 1998 to 2007...
July 2008: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
E Ganio, F Marino, I Giani, A Realis Luc, G Clerico, E Novelli, M Trompetto
BACKGROUND: Passive fecal incontinence is a disabling condition caused by internal anal sphincter dysfunction. The aim of the study was to assess prospectively the effects of calcium hydroxylaptatite ceramic microspheres (Coaptite) as a bulking agents to treat patients with passive fecal incontinence. METHODS: Ten patients with passive fecal incontinence were recruited. All patients were assessed by clinical examination, anal ultrasonography and anal manometry. The severity of incontinence and quality of life were assessed using the Fecal Incontinence Scoring System (FISS) and Fecal Incontinence Quality of Life (FIQoL) questionnaire at baseline and at 3, 6 and 12 months after the Coaptite injection...
June 2008: Techniques in Coloproctology
H Henry Lai, Eric A Hurtado, Rodney A Appell
A 67-year-old woman who had failed two prior anti-incontinence surgeries presented with stress urinary incontinence and intrinsic sphincteric deficiency. Calcium hydroxylapatite (Coaptite(R)) was injected cystoscopically into the bladder neck and proximal urethra and resolved her incontinence. Seven months later, she presented with difficulty in voiding and a urethral mass. Physical examination revealed a large prolapse of the urethral mucosa obstructing the external urethral meatus. Surgical exploration revealed local migration of calcium hydroxylapatite particles from the site of injection (bladder neck and proximal urethra) to the distal urethra...
September 2008: International Urogynecology Journal and Pelvic Floor Dysfunction
Erkan Ozudogru, Hamdi Cakli, Esin Asan, Cemal Cingi, Kezban Gurbuz, Aytekin Yaz, Beklen Ure
Adductor paralysis or the pathologies occurring after laryngeal surgery such as scarring or atrophy of the vocal cords cause glottic insufficiency during phonation. Injection laryngoplasty has been a widely accepted technique due to lower morbidity of the procedure and the applicability via endoscope in the treatment of these pathologies. Various materials have been used in injection laryngoplasty. The primary expectations in these techniques are the persistence of injected material long enough, without resorbtion or any cause of serious tissue response and having beneficial effects in reinforcing the glottic tissue...
February 2008: European Archives of Oto-rhino-laryngology
Edmund Y Ko, Bryant F Williams, Steven P Petrou
Urethral prolapse after injection therapy for incontinence is rare. We report a case of early urethral prolapse in an adult woman with urinary incontinence secondary to distal urethrectomy treated with calcium hydroxylapatite (Coaptite).
December 2007: International Urogynecology Journal and Pelvic Floor Dysfunction
R D Mayer, R R Dmochowski, R A Appell, P K Sand, I W Klimberg, K Jacoby, C W Graham, J A Snyder, V W Nitti, J C Winters
OBJECTIVES: To evaluate the safety and effectiveness of soft-tissue augmentation of the urethral sphincter with calcium hydroxylapatite (CaHA; Coaptite) compared with glutaraldehyde cross-linked bovine collagen (Contigen) in female patients with stress urinary incontinence due to intrinsic sphincter deficiency and without associated urethral hypermobility. METHODS: This 12-month prospective, randomized, comparative, multicenter, single-blind, parallel, clinical trial of CaHA and collagen for soft-tissue augmentation of the urethral sphincter in the treatment of stress urinary incontinence enrolled 296 women...
May 2007: Urology
Miguel Julián Mora Durbán, Francisco Javier Navarro Sebastián, María Belén Muñoz Delgado, Jesús Isidoro García González, Pedro Dionisio Paniagua Andrés
OBJECTIVE: To review our experience in the endoscopic treatment of vesicoureteral reflux (VUR) in children with the subureteral injection of calcium hydroxyapatite (Coaptite). METHODS: The serie includes thirteen children whose age ranged between 6 and 13 years. The Coaptite implant was injected subureterally to 20 ureteral units (UU) affected by VUR grades I-IV. VUR was unilateral in six patients (46%), bilateral in seven (54%). There were 7 primary cases and 6 secondary to bladder dysfunction and duplex systems...
June 2006: Archivos Españoles de Urología
Thierry Merrot, Isso Ouedraogo, Géraldine Hery, Pierre Alessandrini
INTRODUCTION: The objective of this study is to compare the short-term and medium-term efficacy of Coaptite versus Deflux in the endoscopic treatment of vesicoureteric reflux in children. MATERIALS AND METHODS: Over a period of 24 months, a cohort of 31 children with 44 refluxing vesicoureteric units were treated alternately by either Deflux implants (Group I, 24 refluxing units) or Coaptite implants (Group II, 20 refluxing units). This series comprised 40 solitary ureteric systems and 2 complete duplications...
December 2005: Progrès en Urologie
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