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diagnostic test interpretation

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https://www.readbyqxmd.com/read/28108979/analysis-of-stress-only-imaging-comparing-upright-and-supine-czt-camera-acquisition-to-conventional-gamma-camera-images-with-and-without-attenuation-correction-with-coronary-angiography-as-a-reference
#1
Zenith A Jameria, Mouhamad Abdallah, Mariano Fernandez-Ulloa, Robert O'Donnell, Alok K Dwivedi, Erica Washburn, Naseer Khan, Mahyar Khaleghi, Nischelle Kalakota, Myron C Gerson
BACKGROUND: Diagnostic performance of stress-only imaging using a Cadmium-Zinc-Telluride (CZT) camera has not been directly compared in the same patients to stress-only attenuation-corrected conventional Anger camera images. METHODS: 112 subjects with correlative coronary angiographic data and 40 subjects with <5% pre-test likelihood of coronary disease completed attenuation-corrected stress-only images on a conventional Anger camera and uncorrected upright and supine stress images on a CZT camera...
January 20, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28108881/diagnostic-performance-of-point-of-care-ultrasonography-in-identifying-the-etiology-of-respiratory-distress-in-neonates
#2
Harish Rachuri, Tejo Pratap Oleti, Srinivas Murki, Sreeram Subramanian, Jayalatha Nethagani
OBJECTIVES: To determine the diagnostic test performance of Point of care ultrasonography (PoC-USG) for identifying the etiology of respiratory distress (RD) in neonates when combination of radiological and clinical criteria is considered as the gold standard. METHODS: A neonate was included in the study if he/she had RD and underwent x-ray chest and ultrasound within 4 h of admission and the age was less than 24 h. The neonates admitted with non-respiratory illness were chosen as controls...
January 21, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28106896/the-2016-bowman-lecture-conjunctival-curses-scarring-conjunctivitis-30-years-on
#3
J K Dart
This review is in two sections. The first section summarises 35 conditions, both common and infrequent, causing cicatrising conjunctivitis. Guidelines for making a diagnosis are given together with the use of diagnostic tests, including direct and indirect immunofluorescence, and their interpretation. The second section evaluates our knowledge of ocular mucous membrane pemphigoid, which is the commonest cause of cicatrizing conjunctivitis in most developed countries. The clinical characteristics, demographics, and clinical signs of the disease are described...
January 20, 2017: Eye
https://www.readbyqxmd.com/read/28105529/upper-gi-disorders-pathophysiology-and-current-therapeutic-approaches
#4
Henry P Parkman
Symptoms referable to the upper digestive tract are associated with abnormalities of upper gastric neuromuscular function including abnormalities of motility, sensation, and absorption. Of the upper digestive tract, the stomach is of particular importance in its role in symptom generation, and is highlighted in this chapter. Gastric symptoms can be associated with alterations in the rates of gastric emptying, impaired accommodation, heightened gastric sensation, or alterations in gastric myoelectrical activity and contractility...
January 20, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28102752/the-importance-of-conditional-probability-in-diagnostic-reasoning-and-clinical-decision-making-a-primer-for-the-eye-care-practitioner
#5
Paul G Sanfilippo, Alex W Hewitt, David A Mackey
PURPOSE: To outline and detail the importance of conditional probability in clinical decision making and discuss the various diagnostic measures eye care practitioners should be aware of in order to improve the scope of their clinical practice. METHODS: We conducted a review of the importance of conditional probability in diagnostic testing for the eye care practitioner. RESULTS: Eye care practitioners use diagnostic tests on a daily basis to assist in clinical decision making and optimizing patient care and management...
January 19, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28096286/diagnosis-of-primary-ciliary-dyskinesia-potential-options-for-resource-limited-countries
#6
REVIEW
Nisreen Rumman, Claire Jackson, Samuel Collins, Patricia Goggin, Janice Coles, Jane S Lucas
Primary ciliary dyskinesia is a genetic disease of ciliary function leading to chronic upper and lower respiratory tract symptoms. The diagnosis is frequently overlooked because the symptoms are nonspecific and the knowledge about the disease in the primary care setting is poor. Additionally, none of the available tests is accurate enough to be used in isolation. These tests are expensive, and need sophisticated equipment and expertise to analyse and interpret results; diagnosis is therefore only available at highly specialised centres...
January 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28095964/f-wave-duration-parameters-as-a-specific-and-sensitive-tool-for-diagnosis-of-restless-legs-syndrome
#7
Patrizia Congiu, Maria Livia Fantini, Giulia Milioli, Paolo Tacconi, Michela Figorilli, Gioia Gioi, Bruno Pereira, Francesco Marrosu, Liborio Parrino, Monica Puligheddu
STUDY OBJECTIVES: Restless legs syndrome, also known as Willis-Ekbom disease (RLS/WED), is a frequent condition, though its pathophysiology is not completely understood. The diagnosis of RLS/WED relies on clinical criteria, and the only instrumental tool, the suggested immobilization test, may lead to equivocal results. Recently, neurophysiological parameters related to F-wave duration have been proposed as a diagnostic aid. The aim of this study is to assess and compare the diagnostic values of these parameters in diagnosis of RLS/WED...
January 11, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28093104/faecal-shedding-of-canine-parvovirus-after-modified-live-vaccination-in-healthy-adult-dogs
#8
M Freisl, S Speck, U Truyen, S Reese, A-L Proksch, K Hartmann
Since little is known about the persistence and faecal shedding of canine parvovirus (CPV) in dogs after modified-live vaccination, diagnostic tests for CPV can be difficult to interpret in the post-vaccination period. The primary aim of this study was to determine the incidence, duration and extent of CPV vaccine virus shedding in adult dogs and to investigate related factors, including the presence of protective antibodies, increase in anti-CPV antibody titres and development of any gastrointestinal side-effects...
January 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28088797/automated-interpretation-of-pulmonary-function-tests-in-adults-with-respiratory-complaints
#9
Marko Topalovic, Stefan Laval, Jean-Marie Aerts, Thierry Troosters, Marc Decramer, Wim Janssens
BACKGROUND: The use of pulmonary function tests is primarily based on expert opinion and international guidelines. Current interpretation strategies are using predefined cutoffs for the description of a typical pattern. OBJECTIVES: We aimed to explore the predicted disease outcome based on the American Thoracic Society/European Respiratory Society (ATS/ERS) interpreting strategy. Subsequently, we investigated whether an unbiased machine learning framework integrating lung function with clinical variables may provide alternative decision trees resulting in a more accurate diagnosis...
January 12, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28087402/accuracy-is-in-the-eyes-of-the-pathologist-the-visual-interpretive-process-and-diagnostic-accuracy-with-digital-whole-slide-images
#10
Tad T Brunyé, Ezgi Mercan, Donald L Weaver, Joann G Elmore
Digital whole slide imaging is an increasingly common medium in pathology, with application to education, telemedicine, and rendering second opinions. It has also made it possible to use eye tracking devices to explore the dynamic visual inspection and interpretation of histopathological features of tissue while pathologists review cases. Using whole slide images, the present study examined how a pathologist's diagnosis is influenced by fixed case-level factors, their prior clinical experience, and their patterns of visual inspection...
January 10, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28071062/accurate-cut-offs-for-predicting-endoscopic-activity-and-mucosal-healing-in-crohn-s-disease-with-fecal-calprotectin
#11
Juan María Vázquez Morón, Héctor Pallarés Manrique, Francisco H Machancoses, Manuel Ramos Lora, Carlos Ruiz Frutos
BACKGROUND: Fecal biomarkers, especially fecal calprotectin, are useful for predicting endoscopic activity in Crohn's disease; however, the cut-off point remains unclear. The aim of this paper was to analyze whether faecal calprotectin and M2 pyruvate kinase are good tools for generating highly accurate scores for the prediction of the state of endoscopic activity and mucosal healing. METHODS: The simple endoscopic score for Crohn's disease and the Crohn's disease activity index was calculated for 71 patients diagnosed with Crohn's...
January 10, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28069517/fast-estimation-of-colles-fracture-load-of-the-distal-section-of-the-radius-by-homogenized-finite-element-analysis-based-on-hr-pqct
#12
Hadi S Hosseini, Andreas Dünki, Jonas Fabech, Martin Stauber, Nicolas Vilayphiou, Dieter Pahr, Michael Pretterklieber, Jasmin Wandel, Bert van Rietbergen, Philippe K Zysset
Fractures of the distal section of the radius (Colles' fractures) occur earlier in life than other osteoporotic fractures. Therefore, they can be interpreted as a warning signal for later, more deleterious fractures of vertebral bodies or the femoral neck. In the past decade, the advent of HR-pQCT allowed a detailed architectural analysis of the distal radius and an automated but time-consuming estimation of its strength with linear micro-finite element (μFE) analysis. Recently, a second generation of HR-pQCT scanner (XtremeCT II, SCANCO Medical, Switzerland) with a resolution beyond 61 μm became available for even more refined biomechanical investigations in vivo...
January 7, 2017: Bone
https://www.readbyqxmd.com/read/28056949/the-treatment-of-non-malarial-febrile-illness-in-papua-new-guinea-findings-from-cross-sectional-and-longitudinal-studies-of-health-worker-practice
#13
Olga P M Saweri, Manuel W Hetzel, Ivo Mueller, Peter M Siba, Justin Pulford
BACKGROUND: The Papua New Guinea Department of Health recently shifted from a presumptive to a 'test and treat' malaria case management policy. This shift was supported by the widespread introduction of malaria rapid diagnostic tests in health facilities across the country. Health workers received training and job-aids detailing how to conduct and interpret a malaria rapid diagnostic test and how to treat test positive cases; however, little instruction on treating non-malaria febrile cases was provided...
January 5, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28056601/a-clinical-decision-support-tool-to-assist-with-the-interpretation-of-the-12-lead-electrocardiogram
#14
Cathal Breen, Raymond Bond, Dewar Finlay
This article reports the design and testing of a novel interactive method, abbreviated to ANALYSE (systemAtic aNALYsiS of Electrocardiography) to assist interpretation of 12-lead electrocardiogram. 15 participants interpreted a total of 150 12-lead electrocardiogram recordings randomly using a standard and this novel (ANALYSE) reporting format. The overall aggregated mean score attained using the standard format was 53% (range = 38-82%, standard deviation = 12). Conversely, the overall aggregated mean score attained using ANALYSE format was 75% (range = 55%-93%, standard deviation = 9)...
January 1, 2017: Health Informatics Journal
https://www.readbyqxmd.com/read/28054915/auditory-processing-disorder-as-the-sole-manifestation-of-a-cerebellopontine-and-internal-auditory-canal-lesion
#15
Vasiliki Vivian Iliadou, Nikos Eleftheriadis
BACKGROUND: Clinical importance of auditory processing disorder (APD) testing is often overlooked and regarded with skepticism given the challenging interpretation of results and the current growing debate of its nature and clinical entity. PURPOSE: Presentation of this case is highly educational as APD is the single clinical manifestation of a large cerebellopontine and internal auditory canal lesion. RESEARCH DESIGN: A case report. DATA COLLECTION AND ANALYSIS: The patient underwent a standard audiological evaluation with normal results...
January 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28050486/patch-test-as-a-diagnostic-tool-in-hand-eczema
#16
Natarajan Vigneshkarthik, Satyaki Ganguly, Sheela Kuruvila
INTRODUCTION: Allergic contact dermatitis is an important cause of hand eczema. Patch testing is the only investigation available to prove the diagnosis of allergic contact dermatitis. Exposures to allergens differ according to geographical, occupational, economic and social factors. Accordingly, patterns of allergic contact dermatitis differ in different parts of the world and different regions of the same country. AIM: To study the causes of allergic contact dermatitis in adult patients with hand eczema with the help of patch testing...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28045858/diagnosis-of-electrical-status-epilepticus-during-slow-wave-sleep-with-100-seconds-of-sleep
#17
Amanda B Weber, Dara V Albert, Han Yin, Timothy P Held, Anup D Patel
PURPOSE: Strategies for diagnosing electrical status epilepticus during slow-wave sleep (ESES) vary among interpreting neurologists. Our aim was to evaluate if the spike-wave index (SWI) for the first 100 seconds of sleep is reflective of the SWI when compared with a conventional method. METHODS: We reviewed EEGs from 2005 to 2011 that were considered diagnostic of ESES based on unspecified methods. The SWI for the first nonrapid eye movement sleep cycle (long method) was calculated by two neurophysiologists...
January 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28043385/development-of-a-rapid-antibody-test-for-point-of-care-diagnosis-of-animal-african-trypanosomosis
#18
Alain Boulangé, Davita Pillay, Cyrille Chevtzoff, Nicolas Biteau, Vanessa Comé de Graça, Leonie Rempeters, Dimitrios Theodoridis, Théo Baltz
Trypanosoma congolense and T. vivax are the main causative agents of animal African trypanosomosis (AAT), a disease which hinders livestock production throughout sub-Saharan Africa and in some parts of South America. Although two trypanocidal drugs are currently available, the level of treatment is low due to the difficulty in diagnosing the disease in the field. The major clinical signs of AAT such as anaemia, weight loss, and infertility, are common to several other endemic livestock diseases. Current diagnostic methods, based on the visualization of the parasite in the blood, or on the detection of its DNA or the antibodies it triggers in the host, are not suitable for direct use in the field as they require specialized equipment and personnel...
January 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28040685/using-knowledge-driven-genomic-interactions-for-multi-omics-data-analysis-metadimensional-models-for-predicting-clinical-outcomes-in-ovarian-carcinoma
#19
Dokyoon Kim, Ruowang Li, Anastasia Lucas, Shefali S Verma, Scott M Dudek, Marylyn D Ritchie
It is common that cancer patients have different molecular signatures even though they have similar clinical features, such as histology, due to the heterogeneity of tumors. To overcome this variability, we previously developed a new approach incorporating prior biological knowledge that identifies knowledge-driven genomic interactions associated with outcomes of interest. However, no systematic approach has been proposed to identify interaction models between pathways based on multi-omics data. Here we have proposed such a novel methodological framework, called metadimensional knowledge-driven genomic interactions (MKGIs)...
December 31, 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28039099/individual-patient-data-meta-analysis-of-controlled-attenuation-parameter-cap-technology-for-assessing-steatosis
#20
Thomas Karlas, David Petroff, Magali Sasso, Jian-Gao Fan, Yu-Qiang Mi, Victor de Lédinghen, Manoj Kumar, Monica Lupsor-Platon, Kwang-Hyub Han, Ana C Cardoso, Giovanna Ferraioli, Wah-Kheong Chan, Vincent Wai-Sun Wong, Robert P Myers, Kazuaki Chayama, Mireen Friedrich-Rust, Michel Beaugrand, Feng Shen, Jean-Baptiste Hiriart, Shiv K Sarin, Radu Badea, Kyu Sik Jung, Patrick Marcellin, Carlo Filice, Sanjiv Mahadeva, Grace Lai-Hung Wong, Pam Crotty, Keiichi Masaki, Joerg Bojunga, Pierre Bedossa, Volker Keim, Johannes Wiegand
BACKGROUND: The prevalence of fatty liver underscores the need for non-invasive characterization of steatosis, such as the ultrasound-based controlled attenuation parameter (CAP). Despite good diagnostic accuracy, clinical use of CAP is limited due to uncertainty regarding optimal cut-offs and the influence of covariates. We therefore conducted an individual patient data meta-analysis. METHODS: A review of the literature identified studies containing histology controlled CAP data (M probe, vibration controlled transient elastography with Fibroscan) for grading of steatosis (S0-S3)...
December 27, 2016: Journal of Hepatology
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