Simon Bomken, Amir Enshaei, Edward C Schwalbe, Aneta Mikulasova, Yunfeng Dai, Masood Zaka, Kent Tm Fung, Matthew Bashton, Huezin Lim, Lisa Jones, Nefeli Karataraki, Emily Winterman, Cody Ashby, Andishe Attarbaschi, Yves Bertrand, Jutta Bradtke, Barbara Buldini, G.A. Amos Burke, Giovanni Cazzaniga, Gudrun Gohring, Hesta A De Groot-Kruseman, Claudia Haferlach, Luca Lo Nigro, Mayur Parihar, Adriana Plesa, Emma Seaford, Edwin Sonneveld, Sabine Strehl, Vincent Hj Van der Velden, Vikki Rand, Stephen P Hunger, Christine J Harrison, Chris M Bacon, Frederik W Van Delft, Mignon L Loh, John Moppett, Josef Vormoor, Brian A Walker, Anthony V Moorman, Lisa J Russell
Rarely, immunophenotypically immature B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) carries an immunoglobulin-MYC rearrangement (IG-MYC-r). This can result in diagnostic confusion with Burkitt lymphoma/leukaemia and use of unproven individualised treatment schedules. Here we contrast the molecular characteristics of these conditions and investigate historic clinical outcome data. We identified 90 cases registered on a national BCP-ALL clinical trial/registry. Where present, diagnostic material underwent cytogenetic, exome, methylome and transcriptome analysis...
April 28, 2022: Haematologica