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https://www.readbyqxmd.com/read/27764235/investigating-cd99-expression-in-leukemia-propagating-cells-in-childhood-t-cell-acute-lymphoblastic-leukemia
#1
Charlotte V Cox, Paraskevi Diamanti, John P Moppett, Allison Blair
A significant number of children with T-lineage acute lymphoblastic leukemia (T-ALL) fail to respond to therapy and experience early relapse. CD99 has been shown to be overexpressed on T-ALL cells and is considered to be a reliable detector of the disease. However, the relevance of CD99 overexpression in ALL has not been investigated in a functional context. The aim of this study was to investigate the functional capacity of CD99+ cells in childhood ALL and determine the suitability of CD99 as a therapeutic target...
2016: PloS One
https://www.readbyqxmd.com/read/27501337/standardising-anaesthesia-for-hip-fracture-surgery
#2
EDITORIAL
S M White, R Griffiths, I K Moppett
No abstract text is available yet for this article.
December 2016: Anaesthesia
https://www.readbyqxmd.com/read/27183494/accurate-sample-assignment-in-a-multiplexed-ultrasensitive-high-throughput-sequencing-assay-for-minimal-residual-disease
#3
Jack Bartram, Edward Mountjoy, Tony Brooks, Jeremy Hancock, Helen Williamson, Gary Wright, John Moppett, Nick Goulden, Mike Hubank
High-throughput sequencing (HTS) (next-generation sequencing) of the rearranged Ig and T-cell receptor genes promises to be less expensive and more sensitive than current methods of monitoring minimal residual disease (MRD) in patients with acute lymphoblastic leukemia. However, the adoption of new approaches by clinical laboratories requires careful evaluation of all potential sources of error and the development of strategies to ensure the highest accuracy. Timely and efficient clinical use of HTS platforms will depend on combining multiple samples (multiplexing) in each sequencing run...
July 2016: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/26948476/the-effect-of-prone-positioning-with-surgical-bolsters-on-liver-blood-flow-in-healthy-volunteers
#4
M Chikhani, D L Evans, A W Blatcher, A P Jackson, I N Guha, G P Aithal, I K Moppett
This study sought to identify changes in hepatic flood flow and cardiac output during prone positioning on surgical bolsters in awake volunteers, and was prompted by a local incident of significant hepatic dysfunction following surgery in the prone position. Cardiac output was determined using the non-invasive Peñáz technique, and plasma disappearance rate of indocyanine green (ICG-PDR) was measured as a surrogate maker for hepatic blood flow along with serum hepatic enzyme assays. Measurements were made after one hour in supine, prone and returned supine positions...
May 2016: Anaesthesia
https://www.readbyqxmd.com/read/26940757/prediction-of-30-day-mortality-after-hip-fracture-surgery-by-the-nottingham-hip-fracture-score-and-the-surgical-outcome-risk-tool
#5
MULTICENTER STUDY
T C Marufu, S M White, R Griffiths, S R Moonesinghe, I K Moppett
The care of the elderly with hip fractures and their outcomes might be improved with resources targeted by the accurate calculation of risks of mortality and morbidity. We used a multicentre national dataset to evaluate and recalibrate the Nottingham Hip Fracture Score and Surgical Outcome Risk Tool. We split 9,017 hip fracture cases from the Anaesthesia Sprint Audit of Practice into derivation and validation data sets and used logistic regression to derive new model co-efficients for death at 30 postoperative days...
May 2016: Anaesthesia
https://www.readbyqxmd.com/read/26933157/quality-of-quality-accounts-transparency-of-public-reporting-of-never-events-in-england-a-semi-quantitative-and-qualitative-review
#6
Nazurah Nn Abdul Wahid, Sarah H Moppett, Iain K Moppett
OBJECTIVES: To describe the quality of reporting and investigation into surgical Never Events in public reports. DESIGN: Semi-quantitative and qualitative review of published Quality Accounts for three years (2011/2-2013/14). Data on Never Events were compared with previously collated Never Events rates. Quality of reported investigations was assessed using the London Protocol. SETTING: English National Health Service. PARTICIPANTS: All English acute hospital trusts...
May 2016: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/26875796/the-risk-of-surgical-never-events
#7
EDITORIAL
Iain K Moppett, Sarah H Moppett
No abstract text is available yet for this article.
February 2016: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/26872634/ebf1-pdgfrb-fusion-in-pediatric-b-cell-precursor-acute-lymphoblastic-leukemia-bcp-all-genetic-profile-and-clinical-implications
#8
Claire Schwab, Sarra L Ryan, Lucy Chilton, Alannah Elliott, James Murray, Stacey Richardson, Christopher Wragg, John Moppett, Michelle Cummins, Oliver Tunstall, Catriona A Parker, Vaskar Saha, Nicholas Goulden, Ajay Vora, Anthony V Moorman, Christine J Harrison
The EBF1-PDGFRB gene fusion accounts for <1% of B-cell precursor acute lymphoblastic leukemia (ALL) cases and occurs within the Philadelphia-like ALL subtype. We report 15 EBF1-PDGFRB-positive patients from childhood ALL treatment trials (ALL 97/99, UKALL 2003, UKALL 2011) in the United Kingdom. The fusion arose from interstitial deletion of 5q33 (n = 11), balanced rearrangement (n = 2), or complex rearrangement (n = 2). There was a predominance of females (n = 11), median age of 12 years, and median white blood cell count of 48...
May 5, 2016: Blood
https://www.readbyqxmd.com/read/26865705/excellent-outcome-of-minimal-residual-disease-defined-low-risk-patients-is-sustained-with-more-than-10-years-follow-up-results-of-uk-paediatric-acute-lymphoblastic-leukaemia-trials-1997-2003
#9
Jack Bartram, Rachel Wade, Ajay Vora, Jeremy Hancock, Chris Mitchell, Sally Kinsey, Colin Steward, John Moppett, Nick Goulden
BACKGROUND: Minimal residual disease (MRD) is defined as the presence of sub-microscopic levels of leukaemia. Measurement of MRD from bone marrow at the end of induction chemotherapy (day 28) for childhood acute lymphoblastic leukaemia (ALL) can highlight a large group of patients (>40%) with an excellent (>90%) short-term event-free survival (EFS). However, follow-up in recent published trials is relatively short, raising concerns about using this result to infer the safety of further therapy reduction in the future...
May 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/26597516/surgical-caseload-and-the-risk-of-surgical-never-events-in-england
#10
I K Moppett, S H Moppett
Never Events are medical errors that are believed to be preventable with appropriate measures. We surveyed all English acute NHS trusts to determine the number of surgical Never Events and surgical caseload for 2011-2014. There were 742 surgically related Never Events in three years, with no change in the number annually. The risk of a surgical Never Event was 1 in 16 423 operations (95% CI 1 in 15 283 to 1 in 17 648) or 1 Never Event per 12.9 operating theatres per year (95% CI 1 in 12.1 to 1 in 13.9). The risk of severe harm due to a Never Event was approximately 1 in 238 939 operations...
January 2016: Anaesthesia
https://www.readbyqxmd.com/read/26553425/risk-scoring-models-for-predicting-peri-operative-morbidity-and-mortality-in-people-with-fragility-hip-fractures-qualitative-systematic-review
#11
REVIEW
Takawira C Marufu, Alexa Mannings, Iain K Moppett
RATIONALE: Accurate peri-operative risk prediction is an essential element of clinical practice. Various risk stratification tools for assessing patients' risk of mortality or morbidity have been developed and applied in clinical practice over the years. This review aims to outline essential characteristics (predictive accuracy, objectivity, clinical utility) of currently available risk scoring tools for hip fracture patients. METHODS: We searched eight databases; AMED, CINHAL, Clinical Trials...
December 2015: Injury
https://www.readbyqxmd.com/read/26199406/are-you-missing-leukaemia
#12
EDITORIAL
Ethan S Sen, John P Moppett, A V Ramanan
No abstract text is available yet for this article.
September 2015: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/25818054/is-early-hip-fracture-surgery-safe-for-patients-on-clopidogrel-systematic-review-meta-analysis-and-meta-regression
#13
REVIEW
B Doleman, I K Moppett
INTRODUCTION: Hip fracture is a common presentation in the elderly population, many of whom will be taking the antiplatelet clopidogrel, which has the potential to increase perioperative bleeding. The aim of this systematic review and meta-analysis was to answer the questions: (1) is early hip fracture surgery for patients on clopidogrel associated with worse postoperative outcomes compared to patients not on clopidogrel? (2) is early versus delayed surgery for these patients associated with worse postoperative outcomes? METHODS: A systematic search was conducted of MEDLINE, EMBASE, Cinahl and AMED databases...
2015: Injury
https://www.readbyqxmd.com/read/25764405/a-systematic-review-of-pre-operative-anaemia-and-blood-transfusion-in-patients-with-fractured-hips
#14
REVIEW
L J Potter, B Doleman, I K Moppett
We systematically reviewed the observational associations of anaemia with outcomes and the effects of interventions to increase haemoglobin concentrations following hip fracture in older people. Anaemia on hospital admission was associated with increased mortality, relative risk 1.64 (95% CI 1.47-1.82), p < 0.0001. After adjustment for co-morbidities, the association of anaemia with increased mortality remained in four of eight observational studies. There was no association of postoperative transfusion with mortality after adjusting for covariates...
April 2015: Anaesthesia
https://www.readbyqxmd.com/read/25758401/cognitive-aids-in-medicine-assessment-tool-cmat-preliminary-validation-of-a-novel-tool-for-the-assessment-of-emergency-cognitive-aids
#15
D Evans, R McCahon, M Barley, A Norris, A Khajuria, I Moppett
Applying human factors principles to the design of clinical emergency guidelines is important. The UK Civil Aviation Authority uses a Checklist Assessment Tool for evaluating the content and usability of emergency drills before introduction into service on aircraft. We hypothesised that this model could be used to develop a generic medical tool. A three-stage modified Delphi process was used to adapt the above tool for use in designing medical emergency guidelines. The resulting Cognitive aids in Medicine Assessment Tool was then used to score and rank seven published difficult airway guidelines; the scores were used to assess its validity and reliability...
August 2015: Anaesthesia
https://www.readbyqxmd.com/read/25648939/investigating-the-impact-of-clinical-anaesthetic-practice-on-bacterial-contamination-of-intravenous-fluids-and-drugs
#16
N Mahida, K Levi, A Kearns, S Snape, I Moppett
Syringes (N = 426), ventilator machine swabs (N = 202) and intravenous (IV) fluid administration sets (N = 47) from 101 surgical cases were evaluated for bacterial contamination. Cultures from the external surface of syringe tips and syringe contents were positive in 46% and 15% of cases, respectively. The same bacterial species was cultured from both ventilator and syringe in 13% of cases, and was also detected in the IV fluid administration set in two cases. A significant association was found between emergency cases and contaminated syringes (odds ratio 4...
May 2015: Journal of Hospital Infection
https://www.readbyqxmd.com/read/25581412/correlation-between-microsatellite-discrepancy-scores-and-transplant-outcome-after-haemopoietic-sct-for-pediatric-all
#17
J Harvey, A Green, S J Groves, J Cornish, J Moppett, M Cummins, L Keen, S Culliford, A Poles, W Hulme, Y Li, C G Steward
Microsatellite analyses show that self-reported ethnicity often correlates poorly with true genetic ancestry. As unknown ancestral differences could potentially have an impact on transplant outcome, we developed an average allele length discrepancy (AALD) score to assess allele length discrepancy between donor/recipient (D/R) using microsatellites analysed routinely in post-transplant chimeric assessment. This was then compared with outcome in a homogeneously treated cohort of pediatric patients undergoing high-resolution sibling or matched unrelated donor transplantation for acute lymphoblastic leukemia (ALL)...
March 2015: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/25500941/dynamic-preload-markers-to-predict-fluid-responsiveness-during-and-after-major-gastrointestinal-surgery-an-observational-substudy-of-the-optimise-trial
#18
RANDOMIZED CONTROLLED TRIAL
N MacDonald, T Ahmad, O Mohr, J Kirk-Bayley, I Moppett, C J Hinds, R M Pearse
BACKGROUND: Stroke volume variation (SVV) and pulse pressure variation (PPV), termed dynamic markers of preload responsiveness, may predict the response to i.v. fluid in critically ill patients. However, the predictive accuracy of these variables during gastrointestinal surgery remains uncertain. METHODS: Observational study of patients aged ≥50 yr undergoing major gastrointestinal surgery, enrolled in the OPTIMISE trial. Patients received six 250 ml fluid challenges with i...
April 2015: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/25500940/lidco-based-fluid-management-in-patients-undergoing-hip-fracture-surgery-under-spinal-anaesthesia-a-randomized-trial-and-systematic-review
#19
RANDOMIZED CONTROLLED TRIAL
I K Moppett, M Rowlands, A Mannings, C G Moran, M D Wiles
BACKGROUND: Hip fracture is a condition with high mortality and morbidity in elderly frail patients. Intraoperative fluid optimization may be associated with benefit in this population. We investigated whether intraoperative fluid management using pulse-contour analysis cardiac monitoring, compared with standard care in patients undergoing spinal anaesthesia, would provide benefits in terms of reduced time until medically fit for discharge and postoperative complications. METHODS: Patients undergoing surgical repair of fractured neck of femur, aged >60 yr, receiving spinal anaesthesia were enrolled in this single-centre, blinded, randomized, parallel group trial...
March 2015: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/25472724/pre-operative-nutrition-in-neck-of-femur-trial-point-carbohydrate-loading-in-patients-with-fragility-hip-fracture-study-protocol-for-a-randomised-controlled-trial
#20
RANDOMIZED CONTROLLED TRIAL
Iain K Moppett, Paul L Greenhaff, Ben J Ollivere, Theophillus Joachim, Dileep N Lobo, Martin Rowlands
BACKGROUND: Trauma such as hip fracture initiates a neurohumoral stress response that changes the balance between anabolism and catabolism resulting in muscle breakdown and reduced mobilisation. Various studies have demonstrated a reduction in catabolism with pre-operative carbohydrate loading but only in an elective setting. METHODS/DESIGN: This is a two-centre, randomised double-blinded trial in the United Kingdom. Sample size will be 30 patients (approximately 15 from each centre)...
December 4, 2014: Trials
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