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https://www.readbyqxmd.com/read/29131699/genotype-specific-minimal-residual-disease-interpretation-improves-stratification-in-pediatric-acute-lymphoblastic-leukemia
#1
David O'Connor, Amir Enshaei, Jack Bartram, Jeremy Hancock, Christine J Harrison, Rachael Hough, Sujith Samarasinghe, Claire Schwab, Ajay Vora, Rachel Wade, John Moppett, Anthony V Moorman, Nick Goulden
Purpose Minimal residual disease (MRD) and genetic abnormalities are important risk factors for outcome in acute lymphoblastic leukemia. Current risk algorithms dichotomize MRD data and do not assimilate genetics when assigning MRD risk, which reduces predictive accuracy. The aim of our study was to exploit the full power of MRD by examining it as a continuous variable and to integrate it with genetics. Patients and Methods We used a population-based cohort of 3,113 patients who were treated in UKALL2003, with a median follow-up of 7 years...
November 13, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29028912/evidence-based-medicine-the-clue-is-in-the-name
#2
I K Moppett, R M Pearse
No abstract text is available yet for this article.
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28854560/the-princes-of-serendip
#3
I K Moppett, S R Moonesinghe, M P Grocott
No abstract text is available yet for this article.
August 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28796652/acyanotic-hypoxia-in-a-febrile-child
#4
Fiona Murphy, Julian Blackham, John Moppett, Mark Lyttle
Glucose-6-phosphate dehydrogenase deficiency affects approximately 400 million people worldwide and is an X-linked disorder most commonly found in individuals of African, Asian, Mediterranean, and Middle Eastern descent. It can present with acute hemolysis in response to certain drugs, infections, or fava beans, and affected individuals may not be aware that they have glucose-6-phosphate dehydrogenase deficiency. This case illustrates the importance of those working in the acute and urgent care sector having an awareness of the condition and the value of a full set of vital signs in an unwell child...
August 7, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28743315/tight-intra-operative-blood-pressure-control-versus-standard-care-for-patients-undergoing-hip-fracture-repair-hip-fracture-intervention-study-for-prevention-of-hypotension-hip-hop-trial-study-protocol-for-a-randomised-controlled-trial
#5
Iain Keith Moppett, Stuart White, Richard Griffiths, Donal Buggy
BACKGROUND: Hypotension during anaesthesia for hip fracture surgery is common. Recent data suggest that there is an association between the lowest intra-operative blood pressure and mortality, even when adjusted for co-morbidities. This is consistent with data derived from the wider surgical population, where magnitude and duration of hypotension are associated with mortality and peri-operative complications. However, there are no trial to data to support more aggressive blood pressure control...
July 25, 2017: Trials
https://www.readbyqxmd.com/read/28660828/predictors-of-direct-home-discharge-following-fractured-neck-of-femur
#6
O Salar, P N Baker, D P Forward, B J Ollivere, N Weerasuriya, I K Moppett, C G Moran
INTRODUCTION Direct home discharge (DHD) following hip fracture surgery represents a challenging proposition. The aim of this study was to identify factors influencing the discharge destination (home vs alternative location) for patients admitted from their own home with a fractured neck of femur. METHODS A retrospective cohort study of prospectively collected major trauma centre data was performed, identifying 10,044 consecutive hip fracture admissions between 2000 and 2012. RESULTS Two-thirds of the patients (n=6,742, 67%) were admitted from their own home...
July 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28622302/evaluation-of-coagulopathy-before-and-during-induction-chemotherapy-for-acute-lymphoblastic-leukaemia-including-assessment-of-global-clotting-tests
#7
K Burley, J Salem, T Phillips, C Reilly-Stitt, D I Marks, O Tunstall, J Moppett, A Mumford, C A Bradbury
No abstract text is available yet for this article.
June 16, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28585391/understanding-mortality-rates-after-hip-fracture-repair-using-asa-physical-status-in-the-national-hip-fracture-database
#8
A Johansen, C Tsang, C Boulton, R Wakeman, I Moppett
Hip fracture is the most common reason for older patients to need emergency anaesthesia and surgery. Up to one-third of patients die in the year after hip fracture, but this view of outcome may encourage therapeutic nihilism in peri-operative decisions and discussions. We used a multicentre national dataset to examine relative and absolute mortality rates for patients presenting with hip fracture, stratified by ASA physical status. We analysed ASA physical status, dates of surgery, death and hospital discharge for 59,369 out of 64,864 patients in the 2015 National Hip Fracture Database; 3914 (6...
August 2017: Anaesthesia
https://www.readbyqxmd.com/read/28403394/national-audits-in-the-uk-fancy-acronyms-or-real-patient-benefit
#9
I K Moppett, S R Moonesinghe, M P Grocott
No abstract text is available yet for this article.
April 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28167748/does-achieving-the-best-practice-tariff-improve-outcomes-in-hip-fracture-patients-an-observational-cohort-study
#10
B Oakley, J Nightingale, C G Moran, I K Moppett
OBJECTIVES: To determine if the introduction of the best practice tariff (BPT) has improved survival of the elderly hip fracture population, or if achieving BPT results in improved survival for an individual. SETTING: A single university-affiliated teaching hospital. PARTICIPANTS: 2541 patients aged over 60 admitted with a neck of femur fracture between 2008 and 2010 and from 2012 to 2014 were included, to create two cohorts of patients, before and after the introduction of BPT...
February 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28088181/acute-and-chronic-kidney-disease-in-elderly-patients-with-hip-fracture-prevalence-risk-factors-and-outcome-with-development-and-validation-of-a-risk-prediction-model-for-acute-kidney-injury
#11
Christine J Porter, Iain K Moppett, Irene Juurlink, Jessica Nightingale, Christopher G Moran, Mark A J Devonald
BACKGROUND: Hip fracture is a common injury in older people with a high rate of postoperative morbidity and mortality. This patient group is also at high risk of acute kidney injury (AKI) and chronic kidney disease (CKD), but little is known of the impact of kidney disease on outcome following hip fracture. METHODS: An observational cohort of consecutive patients with hip fracture in a large UK secondary care hospital. Predictive modelling of outcomes using development and validation datasets...
January 14, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28045622/use-of-minimal-residual-disease-assessment-to-redefine-induction-failure-in-pediatric-acute-lymphoblastic-leukemia
#12
David O'Connor, Anthony V Moorman, Rachel Wade, Jeremy Hancock, Ronald M R Tan, Jack Bartram, John Moppett, Claire Schwab, Katharine Patrick, Christine J Harrison, Rachael Hough, Nick Goulden, Ajay Vora, Sujith Samarasinghe
Purpose Our aim was to determine the role of end-of-induction (EOI) minimal residual disease (MRD) assessment in the identification and stratification of induction failure in patients with pediatric acute lymphoblastic leukemia (ALL) and to identify genetic abnormalities that drive disease in these patients. Patients and Methods Analysis included 3,113 patients who were treated in the Medical Research Council UKALL2003 multicenter randomized trial (NCT00222612) between 2003 and 2011. MRD was measured by using standardized real-time quantitative PCR...
February 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27764235/investigating-cd99-expression-in-leukemia-propagating-cells-in-childhood-t-cell-acute-lymphoblastic-leukemia
#13
Charlotte V Cox, Paraskevi Diamanti, John P Moppett, Allison Blair
A significant number of children with T-lineage acute lymphoblastic leukemia (T-ALL) fail to respond to therapy and experience early relapse. CD99 has been shown to be overexpressed on T-ALL cells and is considered to be a reliable detector of the disease. However, the relevance of CD99 overexpression in ALL has not been investigated in a functional context. The aim of this study was to investigate the functional capacity of CD99+ cells in childhood ALL and determine the suitability of CD99 as a therapeutic target...
2016: PloS One
https://www.readbyqxmd.com/read/27501337/standardising-anaesthesia-for-hip-fracture-surgery
#14
EDITORIAL
S M White, R Griffiths, I K Moppett
No abstract text is available yet for this article.
December 2016: Anaesthesia
https://www.readbyqxmd.com/read/27183494/accurate-sample-assignment-in-a-multiplexed-ultrasensitive-high-throughput-sequencing-assay-for-minimal-residual-disease
#15
Jack Bartram, Edward Mountjoy, Tony Brooks, Jeremy Hancock, Helen Williamson, Gary Wright, John Moppett, Nick Goulden, Mike Hubank
High-throughput sequencing (HTS) (next-generation sequencing) of the rearranged Ig and T-cell receptor genes promises to be less expensive and more sensitive than current methods of monitoring minimal residual disease (MRD) in patients with acute lymphoblastic leukemia. However, the adoption of new approaches by clinical laboratories requires careful evaluation of all potential sources of error and the development of strategies to ensure the highest accuracy. Timely and efficient clinical use of HTS platforms will depend on combining multiple samples (multiplexing) in each sequencing run...
July 2016: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/26948476/the-effect-of-prone-positioning-with-surgical-bolsters-on-liver-blood-flow-in-healthy-volunteers
#16
M Chikhani, D L Evans, A W Blatcher, A P Jackson, I N Guha, G P Aithal, I K Moppett
This study sought to identify changes in hepatic flood flow and cardiac output during prone positioning on surgical bolsters in awake volunteers, and was prompted by a local incident of significant hepatic dysfunction following surgery in the prone position. Cardiac output was determined using the non-invasive Peñáz technique, and plasma disappearance rate of indocyanine green (ICG-PDR) was measured as a surrogate maker for hepatic blood flow along with serum hepatic enzyme assays. Measurements were made after one hour in supine, prone and returned supine positions...
May 2016: Anaesthesia
https://www.readbyqxmd.com/read/26940757/prediction-of-30-day-mortality-after-hip-fracture-surgery-by-the-nottingham-hip-fracture-score-and-the-surgical-outcome-risk-tool
#17
MULTICENTER STUDY
T C Marufu, S M White, R Griffiths, S R Moonesinghe, I K Moppett
The care of the elderly with hip fractures and their outcomes might be improved with resources targeted by the accurate calculation of risks of mortality and morbidity. We used a multicentre national dataset to evaluate and recalibrate the Nottingham Hip Fracture Score and Surgical Outcome Risk Tool. We split 9,017 hip fracture cases from the Anaesthesia Sprint Audit of Practice into derivation and validation data sets and used logistic regression to derive new model co-efficients for death at 30 postoperative days...
May 2016: Anaesthesia
https://www.readbyqxmd.com/read/26933157/quality-of-quality-accounts-transparency-of-public-reporting-of-never-events-in-england-a-semi-quantitative-and-qualitative-review
#18
REVIEW
Nazurah Nn Abdul Wahid, Sarah H Moppett, Iain K Moppett
OBJECTIVES: To describe the quality of reporting and investigation into surgical Never Events in public reports. DESIGN: Semi-quantitative and qualitative review of published Quality Accounts for three years (2011/2-2013/14). Data on Never Events were compared with previously collated Never Events rates. Quality of reported investigations was assessed using the London Protocol. SETTING: English National Health Service. PARTICIPANTS: All English acute hospital trusts...
May 2016: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/26875796/the-risk-of-surgical-never-events
#19
EDITORIAL
Iain K Moppett, Sarah H Moppett
No abstract text is available yet for this article.
February 2016: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/26872634/ebf1-pdgfrb-fusion-in-pediatric-b-cell-precursor-acute-lymphoblastic-leukemia-bcp-all-genetic-profile-and-clinical-implications
#20
Claire Schwab, Sarra L Ryan, Lucy Chilton, Alannah Elliott, James Murray, Stacey Richardson, Christopher Wragg, John Moppett, Michelle Cummins, Oliver Tunstall, Catriona A Parker, Vaskar Saha, Nicholas Goulden, Ajay Vora, Anthony V Moorman, Christine J Harrison
The EBF1-PDGFRB gene fusion accounts for <1% of B-cell precursor acute lymphoblastic leukemia (ALL) cases and occurs within the Philadelphia-like ALL subtype. We report 15 EBF1-PDGFRB-positive patients from childhood ALL treatment trials (ALL 97/99, UKALL 2003, UKALL 2011) in the United Kingdom. The fusion arose from interstitial deletion of 5q33 (n = 11), balanced rearrangement (n = 2), or complex rearrangement (n = 2). There was a predominance of females (n = 11), median age of 12 years, and median white blood cell count of 48...
May 5, 2016: Blood
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