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https://www.readbyqxmd.com/read/28528120/objective-evaluation-of-corneal-and-lens-clarity-in-children-with-type-1-diabetes-mellitus
#1
Kemal Tekin, Merve Inanc, Erdal Kurnaz, Elvan Bayramoglu, Emre Aydemir, Mustafa Koc, Zehra Aycan
PURPOSE: To investigate whether abnormal glucose metabolism and duration of diabetes mellitus (DM) affected the corneal and lens clarity in children with well-controlled Type 1 DM and to compare the results obtained with those in healthy children. DESIGN: Cross-sectional prospective study. METHODS: This multicenter study enrolled 56 patients with DM and 51 control subjects. The duration of DM and the glycosylated hemoglobin (HbA1c) levels of the patients in the DM group were recorded...
May 17, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28527910/radiative-decay-engineering-8-coupled-emission-microscopy-for-lens-free-high-throughput-fluorescence-detection
#2
Liangfu Zhu, Ramachandram Badugu, Douguo Zhang, Ruxue Wang, Emiliano Descrovi, Joseph R Lakowicz
Fluorescence spectroscopy and imaging are now used throughout the biosciences. Fluorescence microscopes, spectrofluorometers, microwell plate readers and microarray imagers all use multiple optical components to collect, redirect and focus the emission onto single point or array imaging detectors. For almost all biological samples, except those with regular nanoscale features, emission occurs in all directions. With the exception of complex microscope objectives with large collection angles (NA ≤ 0.5), all these instruments collect only a small fraction of the total emission...
May 17, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28527593/a-structural-and-functional-study-of-gln147-deamidation-in-%C3%AE-a-crystallin-a-major-site-of-modification-in-human-cataract
#3
Nicholas J Ray, Damien Hall, John A Carver
Deamidation of Glu147 in human αA-crystallin is common in aged cataractous lenses (Hains and Truscott, Invest. Ophthalmol. Vis. Sci. 2010, 51, 3107). Accordingly, this modification may have a causative effect in cataract. αA-crystallin is a small heat-shock molecular chaperone protein that prevents aggregation of proteins and is the principal defence against crystallin protein unfolding and aggregation in the ageing lens. Deamidated Q147E αA-crystallin was structurally characterised using a variety of spectroscopic and biophysical methods, including NMR, circular dichroism and fluorescence spectroscopy and dynamic light scattering...
May 17, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28527374/talking-about-sunbed-tanning-social-representations-and-identity-work
#4
Jennifer Taylor, Michael Murray, Alexandra Lamont
RATIONALE: Despite the publicised health risks associated with its usage, sunbed tanning remains popular in many Western countries. Previous research indicates that knowledge of the harmful effects does not necessarily lead to a reduction in sunbed use. OBJECTIVE: The aim of this study was to develop a more extensive social psychological understanding of sunbed use, in the United Kingdom, by exploring the social representations of sunbed tanning held by both those who use and who have never used sunbeds...
May 9, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28526552/anisometropia-at-age-5-years-after-unilateral-intraocular-lens-implantation-during-infancy-in-the-infant-aphakia-treatment-study-iats
#5
David Weakley, George Cotsonis, M Edward Wilson, David A Plager, Edward G Buckley, Scott R Lambert
PURPOSE: To report the prevalence of anisometropia at age 5 years after unilateral intraocular lens (IOL) implantation in infants. DESIGN: Prospective randomized clinical trial METHODS: Fifty-seven infants in the Infant Aphakia Treatment Study (IATS) with a unilateral cataract were randomized to IOL implantation with an initial targeted postoperative refractive error of either +8D (infants 28 to <48 days of age) or +6D (infants 48-210 days of age). Anisometropia was calculated at age 5 years...
May 16, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28525682/secondary-sulcus-fixed-foldable-iol-implantation-with-25-g-infusion-in-patients-with-previous-ppv-after-open-globe-injury
#6
Tiangeng He, Caiyun You, Song Chen, Xiangda Meng, Yuanyuan Liu, Hua Yan
PURPOSE: To evaluate the safety and efficacy of secondary sulcus-fixed foldable intraocular lens (IOL) implantation through a clear corneal incision with 25-G infusion in patients with previous pars plana vitrectomy (PPV) after open-globe injury, and to analyze postoperative outcomes and prognostic factors of treatment. METHODS: Clinical data of 89 eyes of 89 patients with open-globe injury who underwent secondary sulcus-fixed foldable IOL implantation through a clear corneal incision with 25-G infusion after vitrectomy in our hospital between January 2008 and June 2015 were retrospectively analyzed...
May 16, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28525556/transcriptome-of-the-gsh-depleted-lens-reveals-changes-in-detoxification-and-emt-signaling-genes-transport-systems-and-lipid-homeostasis
#7
Jeremy A Whitson, Xiang Zhang, Mario Medvedovic, Jenny Chen, Zongbo Wei, Vincent M Monnier, Xingjun Fan
Purpose: To understand the effects of glutathione (GSH)-deficiency on genetic processes that regulate lens homeostasis and prevent cataractogenesis. Methods: The transcriptome of lens epithelia and fiber cells was obtained from C57BL/6 LEGSKO (lens GSH-synthesis knockout) and buthionine sulfoximine (BSO)-treated LEGSKO mice and compared to C57BL/6 wild-type mice using RNA-Seq. Transcriptomic data were confirmed by qPCR and Western blot/ELISA on a subset of genes...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28525427/health-in-all-policies-with-a-forensic-nursing-lens-a-tool-for-finding-solutions-to-complex-issues
#8
Alison M Colbert, Lorie S Goshin
No abstract text is available yet for this article.
April 2017: Journal of Forensic Nursing
https://www.readbyqxmd.com/read/28524882/plasmonic-computing-of-spatial-differentiation
#9
Tengfeng Zhu, Yihan Zhou, Yijie Lou, Hui Ye, Min Qiu, Zhichao Ruan, Shanhui Fan
Optical analog computing offers high-throughput low-power-consumption operation for specialized computational tasks. Traditionally, optical analog computing in the spatial domain uses a bulky system of lenses and filters. Recent developments in metamaterials enable the miniaturization of such computing elements down to a subwavelength scale. However, the required metamaterial consists of a complex array of meta-atoms, and direct demonstration of image processing is challenging. Here, we show that the interference effects associated with surface plasmon excitations at a single metal-dielectric interface can perform spatial differentiation...
May 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28524555/considering-gender-and-student-leadership-through-the-lens-of-intersectionality
#10
Daniel Tillapaugh, Donald Mitchell, Krista M Soria
This chapter explores the concept of intersectionality and its applicability to student leadership development as well as recommendations on how intersectionality can provide transformative learning for students of all gender identities.
June 2017: New Directions for Student Leadership
https://www.readbyqxmd.com/read/28524462/editorial-perspective-neurodiversity-a-revolutionary-concept-for-autism-and-psychiatry
#11
EDITORIAL
Simon Baron-Cohen
Should we continue to refer to autism as a 'disease' or 'disorder', or is the framework of 'neurodiversity' a more humane and accurate lens through which to view people with autism? Evidence at the genetic, neural, behavioural and cognitive levels reveals people with autism show both differences, and signs of disability, but not disorder. Disability requires societal support, acceptance of difference and diversity, and societal "reasonable adjustment", whilst disorder is usually taken to require cure or treatment...
June 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28524241/fabrication-techniques-enabling-ultrathin-nanostructured-membranes-for-separations
#12
REVIEW
Marcela Mireles Ramirez, Thomas R Gaborski
The fabrication of nanostructured materials is an area of continuous improvement and innovative techniques that fulfill the demand of many fields of research and development. The continuously decreasing size of the smallest patternable feature has expanded the catalog of methods enabling the fabrication of nanostructured materials. Several of these nanofabrication techniques have sprouted from applications requiring nanoporous membranes such as molecular separations, cell culture, and plasmonics. This review summarizes methods that successfully produce through-pores in ultrathin films exhibiting an approximate pore size to thickness ratio of one, which has been shown to be beneficial due to high permeability and improved separation potential...
May 19, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28524149/-morphological-features-of-clinical-manifestations-of-particular-congenital-lens-and-vitreous-anomalies
#13
S I Kharlap, A R Salikhova, K S Avetisov, S Е Avetisov
The review covers general clinical features of particular congenital anomalies of the human eye associated with its abnormal embryonic development. Principal literature sources on evaluation of congenital changes in the vitreous body and identification of its 'underdevelopment' in certain types of congenital cataracts have been studied. The said changes were analyzed with account to general pathology of the human body as well as local morphological manifestations. Covered is the time period from the end of the XIX century to the present...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28524144/-new-approaches-to-the-treatment-of-keratoconjunctivitis-sicca
#14
T N Safonova, O V Gladkova, I A Novikov, V I Boev, A A Fedorov
A new method has been developed for the treatment of severe forms of keratoconjunctivitis sicca (KCS) that involves the use of an original cyclosporine A (CyA) saturated soft contact lens (SCL) together with preservative-free artificial tears therapy. AIM: to evaluate the effectiveness of the newly developed treatment for KCS based on the use of medical SCL saturated with 0.05% CyA. MATERIAL AND METHODS: The patients (43 men, 60 eyes) with severe KCS were divided into 2 groups...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28524133/-wavefront-aberrations-and-accommodation-in-myopes-and-hyperopes
#15
V V Neroev, E P Tarutta, S G Arutyunyan, A T Khandzhyan, N V Khodzhabekyan
AIM: to comparatively investigate accommodation, pseudoaccommodation, and higher-order aberrations in children and young adults with myopia and hyperopia. MATERIAL AND METHODS: A total of 39 myopic (the mean error of (-)5.2±1.5 diopters) and 53 hyperopic (the mean error of (+)3.1±1.15 diopters) eyes of 46 patients aged 5-20 years (11.6±0.6 years on average) were enrolled. Examination included evaluation of the objective accommodative response, relative accommodation reserves, pseudoaccommodation volume (calculated as the difference between the (+)3...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28523526/iris-fixated-phakic-intraocular-lens-implantation-in-an-adult-with-retinopathy-of-prematurity-1-year-follow-up
#16
Young Shin Kim, Jin Kwon Chung, Sung Jin Lee
PURPOSE: To report a case of iris-fixated phakic intraocular lens (pIOL) implantation in a patient with an extremely steep cornea, shallow anterior chamber, and small corneal diameter caused by retinopathy of prematurity (ROP) and scleral encircling. METHODS: Case report. RESULTS: Iris-fixated pIOLs were implanted in a 19-year-old patient with refraction of -18.5 -0.75 × 180 in the right eye and -15.5 -1.25 × 180 in the left eye. The keratometric values were 53...
May 18, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28522844/high-performance-pvc-gel-for-adaptive-micro-lenses-with-variable-focal-length
#17
Jin Woo Bae, Eun-Jae Shin, Jaeu Jeong, Dong-Soo Choi, Jong Eun Lee, Byeong Uk Nam, Liwei Lin, Sang-Youn Kim
This paper presents a bio-inspired adaptive micro-lens with electrically tunable focus made of non-ionic high-molecular-weight polyvinyl chloride (PVC) gel. The optical device mimics the design of the crystalline lens and ciliary muscle of the human eye. It consists of a plano-convex PVC gel micro-lens on Indium Tin Oxide (ITO) glass, confined with an annular electrode operating as an artificial ciliary muscle. Upon electrical activation, the electroactive adhesive force of the PVC gel is exerted on the annular anode electrode, which reduces the sagittal height of the plano-convex PVC gel lens, resulting in focal length variation of the micro-lens...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28522252/optical-quality-of-rotationally-symmetrical-contact-lenses-derived-from-their-power-profiles
#18
Antonio J Del Águila-Carrasco, Daniel Monsálvez-Romín, Eleni Papadatou
PURPOSE: To present a methodology for evaluating the optical quality of rotationally symmetrical contact lenses (CLs) from a single power profile. METHODS: Simulated rotationally symmetrical power profiles corresponding to different CLs designs (monofocal, two-zone center-near bifocal, and four-zone center-distance bifocal) were used to calculate the wavefront error profile by means of numerical integration. Then, each lens wavefront error profile was spun around the center to obtain the lens wavefront error surface...
May 15, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28521706/fibrinous-anterior-uveitis-and-recurrent-epithelial-erosion-following-topical-tetracaine-abuse
#19
Olga E Makri, Panagiotis Plotas, Foteini Tsapardoni, Ilias Georgalas, Constantinos D Georgakopoulos
A 54-year-old man presented complaining of severe pain and blurred vision in his left eye. Slit-lamp biomicroscopy revealed a large epithelial defect with an underlying prominent ring infiltrate and severe anterior uveitis with fibrinous exudates and hypopyon. Patient admitted abuse of topical tetracaine, which was discontinued and topical treatment with a non-steroidal anti-inflammatory agent, an antibiotic, a cycloplegic agent were instituted while a therapeutic contact lens was applied. Response to treatment was favorable with a rapid resolution of anterior uveitis within days while the epithelial defect fully healed within a month...
May 18, 2017: Current Drug Safety
https://www.readbyqxmd.com/read/28521451/dosimetric-comparison-of-intensity-modulated-radiation-therapy-and-volumetric-modulated-arc-therapy-plans-for-the-treatment-of-glioma-using-flattening-filter-free-and-flattening-filter-modes
#20
Dandan Xu, Fei Jia, Guowen Li, Hongfei Li
In the present study, the dose verification between 6X and 6X flattening filter-free (FFF) in intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) was compared, and the advantages and disadvantages of different radiotherapy plans were evaluated. All four plans achieved comparable heterogeneity and conformity indices. For frontal tumor, VMAT demonstrated more improved sparing of the brainstem compared with the IMRT (P=0.045); while in the model of FFF, the Dmax of eye lens was significantly reduced by 16-21% (P<0...
May 2017: Oncology Letters
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