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https://www.readbyqxmd.com/read/28108956/post-implantation-fate-of-adipogenic-induced-mesenchymal-stem-cells-on-type-i-collagen-scaffold-in-a-rat-model
#1
Balu Venugopal, Francis B Fernandez, V S Harikrishnan, Annie John
Regenerative medicine via its application in soft tissue reconstruction through novel methods in adipose tissue engineering (ATE) has gained remarkable attention and investment despite simultaneous reports on clinical incidence of graft resorption and impaired vascularization. The underlying malaise here once identified may play a critical role in optimizing implant function. Our work attempts to determine the fate of donor cells and the implant in recipient micro environment using adipose-derived mesenchymal stem cells (ASCs) on a type I collagen sponge, an established scaffold for ATE...
February 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28104397/pink1-alleviates-myocardial-hypoxia-reoxygenation-injury-by-ameliorating-mitochondrial-dysfunction
#2
Yang Li, Liangxian Qiu, Xiping Liu, Zhiwen Hou, Bo Yu
PTEN inducible kinase-1 (PINK1) mutant induces mitochondrial dysfunction of cells, resulting in an inherited form of Parkinson's disease. However its exact role in the cardiomyocytes is unclear. The present study examined the function of PINK1 in hypoxia-reoxygenation (H/R) induced H9c2 cell damage and its potential mechanism. The H/R model in H9c2 cells was established by 6 h of hypoxia and 12 h of reoxygenation. The CCK8 and LDH assay indicated that the cell viability was obviously reduced after H/R. The expression of PINK1 was decreased in H/R-induced H9c2 cells compared with control group...
January 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28101901/cyto-genotoxicity-and-oxidative-stress-in-common-carp-cyprinus-carpio-exposed-to-a-mixture-of-ibuprofen-and-diclofenac
#3
Hariz Islas-Flores, Leobardo Manuel Gómez-Oliván, Marcela Galar-Martínez, Esmeralda Michelle Sánchez-Ocampo, Nely SanJuan-Reyes, Mariana Ortíz-Reynoso, Octavio Dublán-García
Thirty million people worldwide consume each day nonsteroidal anti-inflammatory drugs (NSAIDs), a heterogeneous group of pharmaceuticals used for its analgesic, antipyretic, and anti-inflammatory properties. Recent studies report high NSAID concentrations in wastewater treatment plant effluents, in surface, ground, and drinking water, and in sediments. NSAIDs are also known to induce toxicity on aquatic organisms. However, toxicity in natural ecosystems is not usually the result of exposure to a single substance but to a mixture of toxic agents, yet only a few studies have evaluated the toxicity of mixtures...
January 19, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28094181/the-oxidative-induction-of-dna-lesions-in-cancer-cells-by-5-thio-d-glucose-and-6-thio-d-fructopyranose-and-their-genotoxic-effects-part-3
#4
Anna Czubatka-Bienkowska, Anna Macieja, Joanna Sarnik, Zbigniew J Witczak, Tomasz Poplawski
Thio-sugars have been described as potent inhibitors of cancer cell growth but the detailed mechanism of action remains unknown. Herein we investigated the mechanism of their anticancer action in the HeLa cell line. We investigated two thio-sugars: 5-thio-d-glucose (FCP1) and 6-thio-β-d-fructopyranose (FCP2). We have observed that FCP1 as well as FCP2 clearly induced oxidative DNA lesions in cancer cells and increased the level of cellular ROS. A spin trap and antioxidants have decreased the level of DNA lesions induced by FCPs...
January 7, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28089930/scaffolds-containing-chitosan-gelatin-and-graphene-oxide-for-bone-tissue-regeneration-in-vitro-and-in-vivo
#5
S Saravanan, Anjali C, M Vairamani, T P Sastry, K S Subramanian, N Selvamurugan
Critical-sized bone defects are augmented with cell free and cell loaded constructs to bridge bone defects. Improving the properties of three-dimensional scaffolds with multiple polymers and others is of growing interest in recent decades. Chitosan (CS), a natural biopolymer has limitations for its use in bone regeneration, and its properties can be enhanced with other materials. In the present study, the composite scaffolds containing CS, gelatin (Gn) and graphene oxide (GO) were fabricated through freeze-drying...
January 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28078873/fine-needle-aspiration-cytology-of-650-thyroid-nodules-operated-for-multinodular-goiter-a-cyto-histological-correlation-based-on-the-new-italian-cytological-classification-siapec-2014
#6
F Tartaglia, A Giuliani, L Tromba, S Carbotta, M Karpathiotakis, G Tortorelli, F Pelle, R Merola, C Donello, G Carbotta, L De Anna, G Conzo, S Sorrenti, S Ulisse
The new Italian cytological classification (SIAPEC 2014) of thyroid nodules, in line with those of Bethesda and BTA-RCPath, replaces the previous TIR3 class with two new classes (TIR3A and TIR3B), which correspond to different risks of malignancy and clinical actions required. The present study was conducted to evaluate the diagnostic accuracy of the new SIAPEC classification as opposed to its previous version (SIAPEC 2007). Preoperative cytology was compared with the final histology obtained from 650 consecutive patients who underwent total thyroidectomy for multinodular goiter...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28069498/poly-glycerol-sebacate-poly-%C3%AE%C2%B5-caprolactone-blend-nanofibrous-scaffold-as-intrinsic-bio-and-immunocompatible-system-for-corneal-repair
#7
Sahar Salehi, Marta Czugala, Piotr Stafiej, Mohammadhossein Fathi, Thomas Bahners, Jochen S Gutmann, Bernhard B Singer, Thomas A Fuchsluger
: A major challenge in corneal tissue engineering and lamellar corneal transplantation is to develop synthetic scaffolds able to simulate the optical and mechanical properties of the native cornea. As a carrier, the graft scaffolds should provide the basis for anchorage, repair and regeneration. Although quite a number of scaffolds have been engineered to date, they have not been able to simultaneously recapitulate chemical, mechanical, and structural properties of the corneal extracellular matrix (ECM)...
January 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28067847/the-impact-of-growth-hormone-therapy-on-the-apoptosis-assessment-in-cd34-hematopoietic-cells-from-children-with-growth-hormone-deficiency
#8
Miłosz Piotr Kawa, Iwona Stecewicz, Katarzyna Piecyk, Edyta Paczkowska, Dorota Rogińska, Anna Sobuś, Karolina Łuczkowska, Ewa Pius-Sadowska, Elżbieta Gawrych, Elżbieta Petriczko, Mieczysław Walczak, Bogusław Machaliński
Growth hormone (GH) modulates hematopoietic cell homeostasis and is associated with apoptosis control, but with limited mechanistic insights. Aim of the study was to determine whether GH therapeutic supplementation (GH-TS) could affect apoptosis of CD34+ cells enriched in hematopoietic progenitor cells of GH deficient (GHD) children. CD34+ cells from peripheral blood of 40 GHD children were collected before and in 3rd and 6th month of GH-TS and compared to 60 controls adjusted for bone age, sex, and pubertal development...
January 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28067177/recent-advances-in-application-of-poly-epsilon-caprolactone-and-its-derivative-copolymers-for-controlled-release-of-anti-tumor-drugs
#9
Zhiqiang Sun, Ranglong Duan, Dejun Xing, Xuan Pang, Zhiying Li, Xuesi Chen
Poly-epsilon-caprolactone (PCL) and its derivative copolymers have been extensively studied as drug carriers in pharmaceutical and medical fields, especially for controlled release of anti-tumor drugs. Due to their excellent biocompatibility and biodegradability, PCL based drug delivery systems lead to major advantages including uniform drug distribution, long term of degradation and drug release process, non-toxic in nature and cyto-compatible with body tissues. Approved by US Food and Drug Administration (FDA), PCL provides a promising platform for design and fabrication of anti-tumor drug delivery systems with controllable drug release behaviors...
January 9, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28057697/zonula-occludens-1-nf-%C3%AE%C2%BAb-cxcl8-a-new-regulatory-axis-for-tumor-angiogenesis
#10
Julien Lesage, Meggy Suarez-Carmona, Deborah Neyrinck-Leglantier, Simon Grelet, Silvia Blacher, Walter Hunziker, Philippe Birembaut, Agnes Noël, Béatrice Nawrocki-Raby, Christine Gilles, Myriam Polette
Zonula occludens-1 (ZO-1) is a submembrane scaffolding protein that may display proinvasive functions when it relocates from tight junctions into the cyto-nuclear compartment. This article examines the functional involvement of ZO-1 in CXCL8/IL-8 chemokine expression in lung and breast tumor cells. ZO-1 small interfering RNA and cDNA transfection experiments emphasized regulation of CXCL8/IL-8 expression via a cyto-nuclear pool of ZO-1. Luciferase reporter assays highlighted a 173-bp region of CXCL8/IL-8 promoter that responded to ZO-1...
January 5, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28054588/evaluation-of-10-nitro-oleic-acid-bio-elimination-in-rats-and-humans
#11
Sonia R Salvatore, Dario A Vitturi, Marco Fazzari, Diane K Jorkasky, Francisco J Schopfer
Nitrated fatty acids are endogenously present in human and animal tissues, as well as in plant-derived oils. In particular, 10-nitro oleic acid (10-NO2-OA) potently induces Nrf2-dependent antioxidant gene expression and inhibits TLR4/NF-κB signaling, thus promoting an overall cyto-protective and anti-inflammatory response. 10-NO2-OA has been extensively tested in animal models and is currently undergoing clinical evaluation in humans. Bio-elimination pathways for 10-NO2-OA were evaluated in rats (30 mg/kg·day) and in humans (0...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28042043/first-plastid-phylogenomic-study-reveals-potential-cyto-nuclear-discordance-in-the-evolutionary-history-of-ficus-l-moraceae
#12
Sam Bruun-Lund, Wendy L Clement, Finn Kjellberg, Nina Rønsted
Standard Sanger chloroplast markers provide limited information to resolve species level relationships within plants, in particular within large genera. Figs (Ficus L., Moraceae) compose one of the 50 largest genera of angiosperms with ∼750 species occurring in the tropics and subtropics worldwide. Figs, in addition to being a keystone food resource in rainforests, are well-known for the mutualistic interactions with their pollinating wasps. It is regarded as a model system for understanding co-evolution dating back more than 75million years...
December 29, 2016: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28024694/the-diagnostic-performance-of-routinely-acquired-and-reported-computed-tomography-imaging-in-patients-presenting-with-suspected-pleural-malignancy
#13
Selina Tsim, David B Stobo, Laura Alexander, Caroline Kelly, Kevin G Blyth
OBJECTIVES: Contrast-enhanced computed tomography (CT) provides essential cross-sectional imaging data in patients with suspected pleural malignancy (PM). The performance of CT in routine practice may be lower than in previously reported research. We assessed this relative to 'real-life' factors including use of early arterial-phase contrast enhancement (by CT pulmonary angiography (CTPA)) and non-specialist radiology reporting. MATERIALS AND METHODS: Routinely acquired and reported CT scans in patients recruited to the DIAPHRAGM study (a prospective, multi-centre observational study of mesothelioma biomarkers) between January 2014 and April 2016 were retrospectively reviewed...
January 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28013367/actin-polymerization-plays-a-significant-role-in-asbestos-induced-inflammasome-activation-in-mesothelial-cells-in-vitro
#14
Maximilian MacPherson, Catherine Westbom, Helen Kogan, Arti Shukla
Asbestos exposure leads to malignant mesothelioma (MM), a deadly neoplasm of mesothelial cells of various locations. Although there is no doubt about the role of asbestos in MM tumorigenesis, mechanisms are still not well explored. Recently, our group demonstrated that asbestos causes inflammasome priming and activation in mesothelial cells, which in part is dependent on oxidative stress. Our current study sheds light on yet another mechanism of inflammasome activation by asbestos. Here we show the role of actin polymerization in asbestos-induced activation of the nod-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome...
December 24, 2016: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28007891/general-amino-acid-control-and-14-3-3-proteins-bmh1-2-are-required-for-nitrogen-catabolite-repression-sensitive-regulation-of-gln3-and-gat1-localization
#15
Jennifer J Tate, David Buford, Rajendra Rai, Terrance G Cooper
Nitrogen Catabolite Repression (NCR), the ability of Saccharomyces cerevisiae to utilize good nitrogen sources in preference to poor ones, derives from nitrogen-responsive regulation of the GATA family transcrip-tion activators Gln3 and Gat1. In nitrogen replete conditions the GATA factors are cytoplasmic and NCR-sensitive transcription minimal. When only poor nitrogen sources are available, Gln3 is nuclear dramatically in-creasing GATA factor-mediated transcription. This regulation was originally attributed to mTorC1-mediated control of Gln3...
December 22, 2016: Genetics
https://www.readbyqxmd.com/read/28000658/evaluation-of-left-ventricular-ejection-fractions-in-breast-cancer-patients-undergoing-long-term-trastuzumab-treatment
#16
Yong Sun, Tao Li, Yuanpeng Zhang, Qiwen Zhang
BACKGROUND The aim of this study was to assess the long-term clinical tolerance and cardiac safety during trastuzumab treatment for patients diagnosed as having breast cancer with human epidermal growth factor receptor 2 (HER2) overexpression. MATERIAL AND METHODS A total 105 female cases diagnosed as having breast cancer with high expression of Her2, were treated with trastuzumab (T). All of them underwent electrocardiography monitoring in the process of T treatment. Left ventricular ejection fractions (LVEFs) were estimated using echocardiography before the T treatment and every 3 months...
December 21, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27999781/fine-needle-aspiration-of-skin-metastasis-in-ovarian-cancer-report-of-two-cases-and-review-of-the-literature
#17
Charalampos Charalampidis, Sofia Lampaki, Paul Zarogoulidis, George Lazaridis, Sofia Mpaka, Christoforos Kosmidis, Kosmas Tsakiridis, Ioannis Kioumis, Pavlos Pavlidis, Ilias Karapantzos, Chrysa Karapantzou, Wolfgang Hohenforst-Schmidt, Konstantinos Zarogoulidis
Ovarian cancer is known to be the first cause of death of gynecological malignancy in Europe and United States. Skin metastases consist of an unusual event during the course of ovarian carcinoma and occur in 2-3.5% of the patients. We report two interested cases of patient with skin metastases, due to ovarian carcinoma, diagnosed by fine-needle aspiration (FNA). The clinical information, cytologic findings and immunocytochemical profile are described and further discussed, according to the relevant bibliographic data...
November 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27994511/autophagy-activation-protects-shock-wave-induced-renal-tubular-epithelial-cell-apoptosis-may-through-modulation-of-akt-gsk-3%C3%AE-pathway
#18
Qingzhi Long, Xiang Li, Hui He, Dalin He
PURPOSE: Extracorporeal shock wave lithotripsy (ESWL) is well documented to exert destructive effect to renal cells and its mechanism is not clear. Autophagy is one of cell basic response for stressful conditions and it is important to determine cell's fate. The aim of this study is to elucidate the role of autophagy in the process of shock wave-induced renal cells injury. METHODS: NRK-52E cell, a rat renal tubular epithelial cell, was exposed to shock wave at the voltage of 14KV...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27959869/cyto-and-genotoxic-profile-of-groundwater-used-as-drinking-water-supply-before-and-after-disinfection
#19
C Pellacani, F Cassoni, C Bocchi, A Martino, G Pinto, F Fontana, M Furlini, A Buschini
The assessment of the toxicological properties of raw groundwater may be useful to predict the type and quality of tap water. Contaminants in groundwater are known to be able to affect the disinfection process, resulting in the formation of substances that are cytotoxic and/or genotoxic. Though the European directive (98/83/EC, which establishes maximum levels for contaminants in raw water (RW)) provides threshold levels for acute exposure to toxic compounds, the law does not take into account chronic exposure at low doses of pollutants present in complex mixture...
December 2016: Journal of Water and Health
https://www.readbyqxmd.com/read/27943465/constructing-implantable-srtio3-yb-ho-nanofibers-for-nir-triggered-and-optic-monitored-chemotherapy
#20
Yike Fu, Chao Fang, Zhaohui Ren, Gang Xu, Xiang Li, Gaorong Han
Light-responsive and photoluminescent (PL) drug delivery platforms have sparked fascinating advancement in personalized tumor chemotherapy due to its unique characteristics in biological imaging and manipulated release kinetics. Herein, an implantable Yb3+ and Ho3+ co-doped strontium titanate (SrTiO3:Yb,Ho, STO) nanofibers were synthesized and decorated with polyacrylic acid (PAA) molecules at the surface. The preliminary in-vitro assay confirmed that this implantable fibrous mesh presented sound cyto-compatibility...
December 12, 2016: Chemistry: a European Journal
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