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https://www.readbyqxmd.com/read/29782145/stackable-lab-on-paper-device-with-all-in-one-au-electrode-for-high-efficiency-photoelectrochemical-cyto-sensing
#1
Hongmei Yang, Yan Zhang, Lina Zhang, Kang Cui, Shenguang Ge, Jiadong Huang, Jinghua Yu
Highly conductive, robust, and multifunctional integrated paper-supported electrodes are requisite to fulfill the promise of paper-based analytical application. Herein, an all-in-one Au electrode comprising of detection zone, waterproof electronic bridge, and signal output contactor was engineered via combining the double-sided growth method with the secondary wax-printing. Benefiting from the strongly omnidirectional conductivity and desirably mechanical robustness of the as-prepared electrode, a stackable lab-on-paper cyto-device integrated with high-efficiency photoelectrochemical strategy was developed for the MCF-7 cells assay...
May 21, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29781318/hypochlorite-modified-albumins-promote-cell-death-in-the-tubule-interstitium-in-rats-via-mitochondrial-damage-in-obstructive-nephropathy-and-the-protective-effects-of-antioxidant-peptides
#2
Zong-Rui Liu, Si-Qi Chen, Yao-Wei Zou, Xiao-Yu Wu, Hong-Ying Li, Xiao-Qiao Wang, Yue Shi, Hong-Xin Niu
A major feature of the injury sustained by the kidney during obstructive nephropathy is a profound induction of apoptosis in the tubular epithelium. In this study, we explored the central roles of mitochondria and the mechanism of the protective effect of the mitochondrial targeted peptides in tubular cell apoptosis and interstitial fibrosis during obstructive nephropathy. Unilateral ureter obstruction (UUO) was performed on rats, and the animals were randomly assigned to intravenous treatment with normal saline, rat serum albumin (RSA), or HOCl-rat serum albumin (HOCl-RSA) in the presence or absence of SS-31...
May 2018: Free Radical Research
https://www.readbyqxmd.com/read/29780405/quercetin-induced-lifespan-extension-in-podospora-anserina-requires-methylation-of-the-flavonoid-by-the-o-methyltransferase-pamth1
#3
Verena Warnsmann, Saskia Hainbuch, Heinz D Osiewacz
Quercetin is a flavonoid that is ubiquitously found in vegetables and fruits. Like other flavonoids, it is active in balancing cellular reactive oxygen species (ROS) levels and has a cyto-protective function. Previously, a link between ROS balancing, aging, and the activity of O -methyltransferases was reported in different organisms including the aging model Podospora anserina. Here we describe a role of the S -adenosylmethionine-dependent O -methyltransferase PaMTH1 in quercetin-induced lifespan extension...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29777449/potential-of-bacillus-subtilis-lipopeptides-in-anti-cancer-i-induction-of-apoptosis-and-paraptosis-and-inhibition-of-autophagy-in-k562-cells
#4
Haobin Zhao, Lu Yan, Xiaoguang Xu, Chunmei Jiang, Junling Shi, Yawen Zhang, Li Liu, Shuzhen Lei, Dongyan Shao, Qingsheng Huang
The lipopeptide iturin from Bacillus subtilis has been found to have a potential inhibitory effect on breast cancer, alveolar adenocarcinoma, renal carcinoma, and colon adenocarcinoma. In this study, the potential of B. subtilis lipopeptides (a mixture of iturin homologues, concentration of 42.75%) to inhibit chronic myelogenous leukemia was evaluated using K562 myelogenous leukemia cells. The results showed that the lipopeptides could completely inhibit the growth of K562 at 100 μM, with an IC50 value of 65...
May 9, 2018: AMB Express
https://www.readbyqxmd.com/read/29773172/seleno-l-methionine-and-l-ascorbic-acid-differentiate-the-biological-activity-of-doxorubicin-and-its-metal-complexes-as-a-new-anticancer-drugs-candidate
#5
Marzena Matejczyk, Grzegorz Świderski, Renata Świsłocka, Stanisław Józef Rosochacki, Włodzimierz Lewandowski
The most important problems of anti-cancer therapy include the toxicity of the drugs applied to healthy cells and the multi-drug cells resistance to chemotherapeutics. One of the most commonly used anticancer drugs is doxorubicin (DOX) used to treat certain leukemias and non-Hodgkin's lymphomas, as well as bladder, breast, stomach, lung, ovarian, thyroid, multiple myeloma and other cancers. Preliminary studies showed that metal complex with DOX improve its cytostatic activity with changes in their molecular structure and distribution of electrons, resulting in a substantial change of its biological activity (including antitumor activity)...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29761921/trans-cinnamic-aldehyde-inhibit-aggregatibacter-actinomycetemcomitans-induced-inflammation-thp-1-derived-macrophages-via-autophagy-activation
#6
Jin Chung, Sumi Kim, Hyun Ah Lee, Mi Hee Park, Seyeon Kim, Yu Ri Song, HeeSam Na
OBJECTIVES: Inflammation is an essential response against bacterial infection as a host defense mechanism, which can lead to tissue damage. Aggregatibacter actinomycetemcomitans (Aa) is major pathogen for aggressive periodontitis characterized by rapid destruction of periodontal tissue surrounding teeth. Trans-cinnamic aldehyde is a key bioactive compound of the cinnamon extracts, which has anti-inflammatory, antioxidant, antipyretic, antimicrobial, and anti-cancer properties. The objective of the present study was to investigate the anti-inflammatory effect of trans-cinnamic aldehyde against Aa infection in human THP-1 derived macrophages and on Aa-induced periodontitis in mice...
May 15, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29757601/fluorescence-detection-of-bone-microcracks-using-monophosphonated-carbon-dots
#7
Fatemeh Ostadhossein, Lily Benig, Indu Tripathi, Santosh K Misra, Dipanjan Pan
Phosphonated compounds, in particular, bis-analogs are widely applied in clinical settings for the treatment of severe bone turnovers and recently as imaging probes when conjugated with organic fluorophores. Herein, we introduce a bone seeking luminescent probe that shows high binding affinity towards bone minerals based on monophosphonated carbon dots (CDs). The spheroidal CDs tethered with PEG monophosphates are synthesized in a one pot hydrothermal method and are physico-chemically characterized where the retention of phosphonates is confirmed by 13P NMR and XPS...
May 14, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29756612/cancer-of-the-head-and-neck-a-set-of-indicators-based-on-register-and-administrative-data
#8
A Andreano, M Ansarin, D Alterio, R Bruschini, M G Valsecchi, A G Russo
Head and neck (H&N) tumours are a heterogeneous group of neoplasms with 5-year relative survival ranging from about 25% for the hypopharynx to 60% for the larynx in Europe. To improve survival rates, along with therapeutic improvements, it is important to standardise and optimise care received by patients with H&N tumours across different healthcare providers. To reach this goal, it is necessary to evaluate adherence to standards of received care at a population level. Published guidelines can serve as the basis to develop indicators, which can be computed from administrative health databases, measuring the adherence to specific recommendations at the individual level in unselected H&N cancer patients, identified from a population cancer register...
February 2018: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29746835/complement-c3-drives-autophagy-dependent-restriction-of-cyto-invasive-bacteria
#9
Matthew T Sorbara, Elisabeth G Foerster, Jessica Tsalikis, Mena Abdel-Nour, Joseph Mangiapane, Imogen Sirluck-Schroeder, Ivan Tattoli, Rob van Dalen, David E Isenman, John R Rohde, Stephen E Girardin, Dana J Philpott
In physiological settings, the complement protein C3 is deposited on all bacteria, including invasive pathogens. However, because experimental host-bacteria systems typically use decomplemented serum to avoid the lytic action of complement, the impact of C3 coating on epithelial cell responses to invasive bacteria remains unexplored. Here, we demonstrate that following invasion, intracellular C3-positive Listeria monocytogenes is targeted by autophagy through a direct C3/ATG16L1 interaction, resulting in autophagy-dependent bacterial growth restriction...
May 9, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29745729/anti-proliferate-and-apoptosis-triggering-potential-of-methotrexate-transferrin-conjugate-encapsulated-plga-nanoparticles-with-enhanced-cellular-uptake-by-high-affinity-folate-receptors
#10
Ankush Parmar, Atul Jain, Shivani Uppal, S K Mehta, Khuswinder Kaur, Bhupinder Singh, Rajat Sandhir, Shweta Sharma
The objective of the present study is to enhance the permeation of bioactive molecules across highly lipophilic insurmountable blood brain barrier (BBB) using folic acid (FA) functionalized poly(lactic-co-glycolic acid) (PLGA) nanoparticles (FA-PNPs) coated with non-ionic surfactant, Polysorbate 80 (P80 ). The developed Mtx-Tf loaded folic acid anchored PNPs formulation depicted particle size, zeta potential and entrapment efficiency of 109 ± 2.3 nm, -9.38 ± 0.9 mV and 71.0 ± 0.6%, respectively...
May 10, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29737627/papillary-carcinoma-in-thyroglossal-duct-cyst-diagnosis-by-fine-needle-aspiration-cytology-and-immunocytochemistry
#11
Dilip K Das, Smiley A George, Tareq Mohammad, Bency John, Sara S George, Abdulla I Behbehani
Carcinoma associated with thyroglossal duct cyst (TDC) is extremely rare and when it occurs it is invariably papillary carcinoma. A 36-year-old man presented with a midline swelling in the upper part of neck, which was a cystic lesion with multiple septae in ultrasonogram, indicating a thyroglossal duct cyst. The CT scan findings also corroborated the ultrasound report. Fine needle aspiration (FNA) smears showed hemosiderin laden cyst macrophages and occasional papillary cluster of neoplastic cells with central psammoma body and rare intranuclear cytoplasmic inclusions...
May 8, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29729391/in-vivo-quantitative-structural-imaging-of-the-human-midbrain-and-the-superior-colliculus-at-9-4t
#12
Joana R Loureiro, Marc Himmelbach, Thomas Ethofer, Rolf Pohmann, Pascal Martin, Jonas Bause, Klaus Scheffler, Wolfgang Grodd, Gisela E Hagberg
We explored anatomical details of the superior colliculus (SC) by in vivo magnetic resonance imaging (MRI) at 9.4T. The high signal-to-noise ratio allowed the acquisition of high resolution, multi-modal images with voxel sizes ranging between 176 × 132 × 600 μm and (800)3 μm. Quantitative mapping of the longitudinal relaxation rate R1, the effective transverse relaxation rate R2*, and the magnetic susceptibility QSM was performed in 14 healthy volunteers. The images were analyzed in native space as well as after normalization to a common brain space (MNI)...
May 2, 2018: NeuroImage
https://www.readbyqxmd.com/read/29707240/dual-function-of-peroxiredoxin-i-in-lipopolysaccharide-induced-osteoblast-apoptosis-via-reactive-oxygen-species-and-the-apoptosis-signal-regulating-kinase-1-signaling-pathway
#13
Hao Feng, Ziyu Li, Juan Du, Jing Sun, Wei Feng, Dongfang Li, Shanshan Liu, Wei Wang, Hongrui Liu, Norio Amizuka, Minqi Li
Lipopolysaccharide (LPS)-induced osteoblast apoptosis is a prominent factor to the defect in periodontal tissue repair in periodontal disease. LPS challenge contributes to the production of reactive oxygen species (ROS) in periodontitis, and peroxiredoxin 1 (Prx1) is an antioxidant protein that protect cells against oxidative damage from ROS. Without LPS stimulation, apoptotic rates were higher in both Prx1 knockout (Prx1KO ) and Prx1 overexpression (Prx1OE ) cells compared with wild type. After LPS stimulation, intracellular ROS in Prx1KO cells showed the highest level and Prx1OE cells showed the least...
2018: Cell Death Discovery
https://www.readbyqxmd.com/read/29702091/inhibition-of-malat1-sensitizes-liver-cancer-cells-to-5-flurouracil-by-regulating-apoptosis-through-ikk%C3%AE-nf-%C3%AE%C2%BAb-pathway
#14
Zhenguo Pan, De-Gang Ji, Lian-Yue Guan, Xiao Luo, Feng Ma, Bin Yang, Hong-Yu Liu
Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) is involved in tumor cell growth process. However, its role and molecular mechanism in liver cancer is still not fully understood. In this study, we found that MALAT1 was significantly expressed in liver cancer cell lines. And knockdown of MALAT1 suppressed proliferation, migration and invasion of HepG2 cells, accompanied with decrease of Rho-associated coiled-coil-forming protein kinase 1 (ROCK1), α-smooth muscle actin (α-SMA), N-cadherin, Vimentin and TWIST...
April 24, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29694495/in-vivo-assessment-of-cyto-genotoxic-antigenotoxic-and-antifungal-potential-of-costus-spiralis-jacq-roscoe-leaves-and-stems
#15
Wendel C DE Sousa, Andressa T S Paz, Jamira D Rocha, Edemilson C DA Conceição, Luciane M DE Almeida, Lee C Chen, Leonardo L Borges, Elisa F L C Bailão
Costus spiralis is a Brazilian native plant used in popular medicine, but the safety of this therapeutic use needs investigation. So, the aim of this study was to evaluate the cytogenotoxic and antigenotoxic effects of C. spiralis leaves or stems aqueous extracts on Allium cepa root cells. Moreover, a phytochemical screening and an antioxidant and antifungal activities evaluation were performed. C. spiralis aqueous extracts presented cytotoxicity, but no mutagenicity was observed. When the antigenotoxicity was evaluated, C...
April 23, 2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29693975/assessing-breast-cancer-risk-with-an-artificial-neural-network
#16
Mojtaba Sepandi, Maryam Taghdir, Abbas Rezaianzadeh, Salar Rahimikazerooni
Objectives: Radiologists face uncertainty in making decisions based on their judgment of breast cancer risk. Artificial intelligence and machine learning techniques have been widely applied in detection/recognition of cancer. This study aimed to establish a model to aid radiologists in breast cancer risk estimation. This incorporated imaging methods and fine needle aspiration biopsy (FNAB) for cyto-pathological diagnosis. Methods: An artificial neural network (ANN) technique was used on a retrospectively collected dataset including mammographic results, risk factors, and clinical findings to accurately predict the probability of breast cancer in individual patients...
April 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29693552/bio-resin-for-high-resolution-lithography-based-biofabrication-of-complex-cell-laden-constructs
#17
Khoon Lim, Riccardo Levato, Pedro F Costa, Miguel Castilho, Cesar R Alcala-Orozco, Kim M A van Dorenmalen, Ferry P W Melchels, Debby Gawlitta, Gary J Hooper, Jos Malda, Tim B F Woodfield
Lithography-based three-dimensional (3D) printing technologies allow high spatial resolution that exceeds that of typical extrusion-based bioprinting approaches, allowing to better mimic the complex architecture of biological tissues. Additionally, lithographic printing via digital light processing (DLP) enables fabrication of free-form lattice and patterned structures which cannot be easily produced with other 3D printing approaches. While significant progress has been dedicated to the development of cell-laden bioinks for extrusion-based bioprinting, less attention has been directed towards the development of cyto-compatible bioresins and their application in lithography-based biofabrication, limiting the advancement of this promising technology...
April 25, 2018: Biofabrication
https://www.readbyqxmd.com/read/29687202/attenuation-of-aluminum-chloride-induced-neuroinflammation-and-caspase-activation-through-the-akt-gsk-3%C3%AE-pathway-by-hesperidin-in-wistar-rats
#18
Arokiasamy Justin-Thenmozhi, Mathiyazahan Dhivya Bharathi, Ramaraj Kiruthika, Thamilarasan Manivasagam, Anupom Borah, Musthafa Mohamed Essa
Hesperidin, a flavanoglycone abundantly present in citrus fruits, is reported to have antioxidant, anti-inflammatory, and neuroprotective properties. Previous reports from our laboratory indicated the neuroprotective effect of hesperidin against aluminum chloride (AlCl3 )-induced memory loss, acetylcholine esterase hyperactivity, oxidative stress, and enhanced expression of amyloid β protein biosynthesis-related markers. However, their role on AlCl3 -induced inflammation, caspase activation, Tau pathology, altered Akt/GSK 3β signaling pathway, and Aβ clearance marker has not yet been fully elucidated...
April 23, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29680817/relationships-between-plasma-insulin-like-growth-factor-1-and-insulin-concentrations-in-multiparous-dairy-cows-with-cytological-endometritis
#19
Merle Valdmann, Jevgeni Kurykin, Tanel Kaart, Gret-Kristel Mällo, Andres Waldmann
Cytological endometritis (CYTO) is a uterine inflammation characterised by the percentage of polymorphonuclear neutrophils in endometrial cytology. This observational study evaluated the association of blood plasma insulin-like growth factor-1 (IGF-1) and insulin concentrations at -2 weeks prepartum, +1 week and +3 weeks postpartum with the development of CYTO in 119 multiparous Holstein cows. Overall CYTO prevalence was 30.3 per cent. Multivariable logistic regression model revealed the odds of developing CYTO were 3...
April 21, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29665745/heterogeneity-in-ppv-of-ras-mutations-in-cytologically-indeterminate-thyroid-nodules
#20
Fadi Nabhan, Kyle Porter, Mark Lupo, Gregory W Randolph, Kepal Narendra Patel, Richard T Kloos
BACKGROUND: RAS mutations are common in the available mutational analysis of cytologically indeterminate (Cyto-I) thyroid nodules. However, their reported positive predictive value (PPV) for cancer is widely variable. The reason for this variability is unknown and it causes clinical management uncertainty. We performed a systematic review evaluating the PPV for cancer in RAS mutation positive Cyto-I nodules and considered variables that might affect residual heterogeneity across the different studies...
April 18, 2018: Thyroid: Official Journal of the American Thyroid Association
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