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https://www.readbyqxmd.com/read/28938700/liver-cancers-with-stem-progenitor-cell-features-a-rare-chemotherapy-sensitive-malignancy
#1
Bruno Christian Köhler, Nina Waldburger, Kai Schlamp, Dirk Jäger, Karl Heinz Weiss, Henning Schulze-Bergkamen, Peter Schirmacher, Christoph Springfeld
Primary liver tumors are a heterogeneous group of malignancies. Besides classical hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), combined and intermediate forms of liver cancer exist and can express stem-cell markers like nuclear cell adhesion molecule (NCAM-1/CD56), c-kit (CD117) or epithelial cell adhesion molecule (EpCAM) together with high proliferative activity. Liver tumors with progenitor-cell features are associated with an unfavorable prognosis, but the phenotype has not resulted in therapeutic consequences so far...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938697/intensity-modulated-radiotherapy-for-hepatocellular-carcinoma-dosimetric-and-clinical-results
#2
REVIEW
Sun Hyun Bae, Won Il Jang, Hee Chul Park
Since the introduction of 3-dimensional conformal radiotherapy (3DCRT), new radiotherapy techniques have expanded the indication of radiotherapy for the treatment of hepatocellular carcinoma (HCC), from the hitherto palliative to a now curative-intent purpose. Intensity-modulated radiotherapy (IMRT), currently the most advanced radiotherapy technique, is considered an attractive option for the treatment of HCC, and is more widely applied because it can deliver a higher dose to the tumor than 3DCRT while sparing surrounding normal organs...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938688/drag-reducing-polymers-decrease-hepatic-injury-and-metastases-after-liver-ischemia-reperfusion
#3
Samer Tohme, Marina V Kameneva, Hamza O Yazdani, Vikas Sud, Julie Goswami, Patricia Loughran, Hai Huang, Richard L Simmons, Allan Tsung
INTRODUCTION: Surgery, a crucial therapeutic modality in the treatment of solid tumors, can induce sterile inflammatory processes which can result in metastatic progression. Liver ischemia and reperfusion (I/R) injury, an inevitable consequence of hepatic resection of metastases, has been shown to foster hepatic capture of circulating cancer cells and accelerate metastatic growth. Efforts to reduce these negative consequences have not been thoroughly investigated. Drag reducing polymers (DRPs) are blood-soluble macromolecules that can, in nanomolar concentrations, increase tissue perfusion, decrease vascular resistance and decrease near-wall microvascular concentration of neutrophils and platelets thereby possibly reducing the inflammatory microenvironment...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938667/lncrnas-as-prognostic-molecular-biomarkers-in-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#4
Chuqian Zheng, Xiuxia Liu, Leifeng Chen, Zheng Xu, Jianghua Shao
The latest studies have shown that long non-coding RNAs (lncRNAs) may be considered markers as their expression levels were abnormal in cancer and can be used as a molecular biomarker for the potential assessment of cancer prognosis. In this study, we aimed to assess the prognostic value of lncRNA as marker of patients with hepatocellular carcinoma. We performed a detailed search of the PubMed and Embase databases for articles on the prognostic value of various lncRNAs in HCC. We then carefully extracted the relevant data from the articles, and we used the meta-analysis method to analyze these results; heterogeneity and publication bias were also evaluated...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937487/focal-hepatic-glycogenosis-in-a-patient-with-uncontrolled-diabetes-mellitus-type-1
#5
Tetiana Glushko, Sergiy V Kushchayev, Dmitry Trifanov, Aliaksei Salei, Diego Morales, Gerard Berry, Justin Mackey, Oleg M Teytelboym
Hepatomegaly and elevated liver enzymes in patients with diabetes are commonly associated with fatty liver disease. However, physicians often forget about another intrinsic substance that can cause a similar clinical picture-glycogen. Liver stores approximately one third of the total body glycogen and is responsible for blood glucose homeostasis. Excessive hepatocellular glycogen accumulation occurs not only in congenital glycogen storage diseases, but also in acquired conditions associated with hyperglycemic-hyperinsulinemic states such as uncontrolled diabetes mellitus, high-dose corticosteroid use, and dumping syndrome...
September 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28936550/feasibility-and-outcomes-of-percutaneous-thermal-ablation-of-hepatocellular-carcinoma-in-a-transplanted-allograft
#6
Brian T Welch, J J Schmitz, A N Kurup, T D Atwell, M R Callstrom, G Frey, R Paz-Fumagalli, A Allen, K Watt, J Heimbach, G D Schmit
PURPOSE: To examine the safety, feasibility, and oncologic control following percutaneous image-guided thermal ablation of hepatocellular carcinoma (HCC) in a transplanted allograft. MATERIALS AND METHODS: Retrospective review was performed to identify patients who underwent liver transplantation for HCC and subsequently underwent percutaneous hepatic thermal ablation for recurrent HCC within the allograft between January 1st, 2000-September 1st, 2016. Eleven patients with hepatic allograft HCC underwent twelve percutaneous thermal ablation procedures to treat 16 lesions...
September 21, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28933169/-history-and-presence-of-hepatitis-b%C3%A2-and-c%C3%A2-therapy
#7
Petr Husa
Infection with hepatitis B virus (HBV) and hepatitis C virus (HCV) are the worlds major causes of chronic liver disease. Care of patients infected with HBV and HCV and/or over the last 20 years has significantly improved thanks to the better understanding of the pathophysiology of disease, improvement of diagnostic, therapeutic and preventive options. The goal of treatment of chronic hepatitis B is to extend the length of life and improve its quality through the barriers of the progression of chronic hepatitis to cirrhosis, decompensation cirrhosis and hepatocellular carcinoma (HCC)...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28932768/hepatic-adenomatosis-in-liver-cirrhosis
#8
Sonja Gordic, Swan N Thung, Sasan Roayaie, Mathilde Wagner, Bachir Taouli
Hepatocellular adenoma (HCA) is a benign liver tumor most frequently occurring in women using oral contraception. HCA develops in normal or nearly normal livers and is extremely rare in cirrhosis. The authors present magnetic resonance imaging and histopathologic findings in a 57-year-old man with liver cirrhosis and hepatic adenomatosis. As the differentiation between HCA and hepatocellular carcinoma (HCC) can be difficult with imaging, we would like to highlight the importance of ancillary findings such as the presence of iron on MRI, which can be observed in HCA...
2017: European Journal of Radiology Open
https://www.readbyqxmd.com/read/28932365/causal-role-of-infectious-agents-in-cancer-an-overview
#9
REVIEW
Jila Masrour-Roudsari, Soheil Ebrahimpour
Cancer is a complex group of diseases with multiple eventual causes. The underlying causes are not fully known. Thus, learning more about the known causes of cancer is an important issue. Moreover, among these factors, infection and its association to cancers is controversial. Although, it seems that the genome instability of the cells can initiate cancer development. The purpose of this review was to present the role of infection in the development of cancer. Infectious agents, such as hepatitis B (HBV) and C viruses (HCV), Epstein-Barr virus (EBV), human papillomavirus (HPV), human immunodeficiency virus type 1 (HIV-1), Helicobacter pylori (H...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28932315/experimental-hepatic-carcinogenesis-oxidative-stress-and-natural-antioxidants
#10
REVIEW
Velid Unsal, Ergül Belge-Kurutaş
Hepatocellular carcinoma is one of the most common cancers in the world, and it is influenced by agents such as DEN, 2-AAF, phenobarbital, alcohol, aflatoxin B1 metabolite or hepatitis viruses (B and C). Oxidative stress is becoming recognized as a key factor in the progression of hepatocarcinogenesis. Reactive oxygen species can play a leading role in initiation and promotion of hepatic carcinogenesis. The metabolites of DEN Diethylnitrosamine (DEN) mediate the binding of tumour promoters by covalently binding to the DNA with one or two oxidation-providing electrons...
August 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28932118/fabrication-optimization-and-characterization-of-umbelliferone-%C3%AE-d-galactopyranoside-loaded-plga-nanoparticles-in-treatment-of-hepatocellular-carcinoma-in-vitro-and-in-vivo-studies
#11
Vikas Kumar, Prakash Chandra Bhatt, Mahfoozur Rahman, Gaurav Kaithwas, Hani Choudhry, Fahad A Al-Abbasi, Firoz Anwar, Amita Verma
Umbelliferone β-D-galactopyranoside (UFG), isolated from plants, exhibits promising inhibitory action on numerous diseases. The present research was initiated to develop a suitable delivery system for UFG with an intention to enhance its therapeutic efficacy against diethyl nitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in Wistar rats. UFG-loaded polymeric nanoparticles prepared by sonication were scrutinized for average size, drug loading capacity, zeta potential, and drug release potency in animals...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28932078/long-non-coding-rnas-in-hepatocellular-carcinoma-potential-roles-and-clinical-implications
#12
REVIEW
Zhao-Shan Niu, Xiao-Jun Niu, Wen-Hong Wang
Long non-coding RNAs (lncRNAs) are a subgroup of non-coding RNA transcripts greater than 200 nucleotides in length with little or no protein-coding potential. Emerging evidence indicates that lncRNAs may play important regulatory roles in the pathogenesis and progression of human cancers, including hepatocellular carcinoma (HCC). Certain lncRNAs may be used as diagnostic or prognostic markers for HCC, a serious malignancy with increasing morbidity and high mortality rates worldwide. Therefore, elucidating the functional roles of lncRNAs in tumors can contribute to a better understanding of the molecular mechanisms of HCC and may help in developing novel therapeutic targets...
August 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28930552/microrna-181a-inhibits-autophagy-by-targeting-atg5-in-hepatocellular-carcinoma
#13
Jun Yang, Youzhao He, Niankuan Zhai, Sheng Ding, Jianping Li, Zhihai Peng
Available evidence suggests that autophagy may serve as a tumor suppressor in cases of chronic liver disease and liver cirrhosis and that autophagic deficiency may lead to hepatocellular carcinoma (HCC). Recent studies suggested that the development of several tumor types could be regulated by microRNA-181a. However, the role of miR-181a in the autophagy of HCC remains unclear. In this study, we aimed to investigate the role of miR-181a in the autophagy of HCC. We found that the mRNA expression of miR-181a is higher but the level of autophagy is lower in human HCC compared to normal liver tissue...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28929688/-apoptosis-of-hepatocellular-induced-by-active-ingredients-of-zanthoxyli-radix-by-raman-spectroscopy
#14
Xiao-Li Mao, Yu Qin, Xiang-Yi Chen, Xiao-Cong Kuang, Shu-Shi Huang, Hua-Gang Liu
The apoptosis of mono-hepatocellular induced by the active ingredients of the Zanthoxyli Radix was investigated using laser Raman spectroscopy. Hepatoma cells (BEL-7404) were treated with 10 mg•L⁻¹ nitidine chloride and 3 g•L⁻¹ the extracts of Zanthoxyli Radix, respectively, then were divided into two parts, one for fluorescence staining, the other for determination of Raman spectroscopy. The acquired spectra were then processed by background elimination, smoothing, and normalization. Fluorescence staining results showed that the nucleuses from untreated group were uniformly stained, while those from the group treated for 48 hours were densely stained and broken...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28929364/anthropomorphic-liver-phantom-with-flow-for-multimodal-image-guided-liver-therapy-research-and-training
#15
Anna Rethy, Jørn Ove Sæternes, Jostein Halgunset, Ronald Mårvik, Erlend F Hofstad, Juan A Sánchez-Margallo, Thomas Langø
PURPOSE: The objective of this study was to develop a multimodal, permanent liver phantom displaying functional vasculature and common pathologies, for teaching, training and equipment development in laparoscopic ultrasound and navigation. METHODS: Molten wax was injected simultaneously into the portal and hepatic veins of a human liver. Upon solidification of the wax, the surrounding liver tissue was dissolved, leaving a cast of the vessels. A connection was established between the two vascular trees by manually manipulating the wax...
September 19, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28928838/puerarin-increases-the-chemosensitivity-of-hepatocellular-carcinoma-cells
#16
Zhen Wu, Jing Wu, Ping Fang, Shifeng Kan
The present study investigated the effect of puerarin (Pu) on the sensitivity of HepG2 human hepatocellular carcinoma (HCC) cells to chemotherapeutic drugs to determine the possible mechanism. HepG2 cells were treated with different concentrations of Pu and cisplatin (CDDP), alone or in combination. MTT assay was used to determine the inhibitory effects of the different drugs on HepG2 cells. Cell morphology was observed by inverted microscopy. The expression of B-cell lymphoma 2 (Bcl-2) and Bax protein was measured by western blot analysis...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927121/the-role-of-jagged1-notch-pathway-mediated-angiogenesis-of-hepatocarcinoma-cells-in-vitro-and-the-effects-of-the-spleen-invigorating-and-blood-stasis-removing-recipe
#17
Juze Lin, Yongxin Lin, Le Su, Qiao Su, Wei Guo, Xuhui Huang, Changjun Wang, Lizhu Lin
The objective of this study was to observe the effect of Jagged1/Notch pathway-mediated angiogenesis on the in vitro proliferation of hepatocellular carcinoma cells, and the effect and possible mechanism of the spleen-invigorating and blood stasis-removing recipe. Spleen-invigorating and blood stasis-removing recipe serum from SPF grade nude mice was prepared, and the fingerprint of the drugs of the spleen-invigorating and blood stasis-removing recipe and drug serum were identified by HPLC. SMMC-7721 human hepatocellular carcinoma cells were divided into the normal control group, DAPT inhibitor control group, and drug serum group according to the different treatments...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28925496/study-on-the-relationship-between-the-rassf10-gene-and-the-biological-behavior-of-hepatocellular-carcinoma-cells
#18
J Xie, Y Chen, F Meng, T Shu, Y Liu, L Zhang, Z-X Zhang
OBJECTIVE: To investigate the relationship between Ras association domain family gene 10 (RASSF10 gene) and the biological behavior of hepatocellular carcinoma (HCC), including proliferation, invasion, and metastasis. MATERIALS AND METHODS: HCC cell lines were generated with stable overexpression or low expression of RASSF10 protein. A cell line transfected with an empty vector was treated as control. At 12, 24, 48, and 72 h, the cell proliferation was determined by MTT assay, the invasion ability was determined by Transwell chambers, and the scratch assay was used to assess the migration ability...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28925487/mir-370-functions-as-prognostic-marker-in-patients-with-hepatocellular-carcinoma
#19
X-P Pan, L-H Huang, X Wang
OBJECTIVE: Large body of evidence has shown that microRNAs (miRNAs) have the potential to serve as prognosis marker. This study is designed to investigate the expression of miR-370 in hepatocellular carcinoma (HCC) patients and to analyze its potential prognostic value. PATIENTS AND METHODS: Quantitative real-time quantitative PCR (qPCR) was performed to examine the miR-370 level in HCC tissue and matched normal tissue from 83 HCC patients. The correlation of miR-370 level in HCC tissue with the clinicopathological characteristics was analyzed...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28924964/mir-490-5p-inhibits-hepatocellular-carcinoma-cell-proliferation-migration-and-invasion-by-directly-regulating-robo1
#20
Weiqing Chen, Lijun Ye, Dengcheng Wen, Feihua Chen
Studies have investigated the effect of ROBO1. All the same, the relationship between miR-490-5p and ROBO1, and the underlying mechanism are still unclear. We aimed to study the effect of microRNA-490-5p (miR-490-5p) on hepatocellular carcinoma (HCC) cell proliferation, migration and invasion by directly regulating ROBO1. The expression of miR-490-5p and ROBO1 in HCC tissues and cells were tested by RT-qPCR, and the Hep3B cells were selected for subsequent experiments. We confirmed the relationship between miR-490-5p and ROBO1 by luciferase reporter system...
September 19, 2017: Pathology Oncology Research: POR
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