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Yituo Wang, Yuyang Zhu, Pinhong Chen, Feng Yan, Shanshan Chen, Gongjie Li, Xiangjun Hu, Lubin Wang, Zheng Yang
The amygdala, a subcortical structure responsible for fear and vigilance, is central to the stress circuitry. Aberrant amygdala connectivity with the cortical and subcortical regions is found in patients with stress-related disorders, and in healthy subjects following acute stress exposure. However, the extent to which the stress-induced alteration of amygdala functional connectivity correlates with risk-related personality measures remains unclear. Using resting-state functional magnetic resonance imaging, we evaluated the effect of acute stress, induced by aversive movies accompanied by a mild electric shock, on the functional connectivity of the basolateral amygdala (BLA) and centromedial amygdala (CMA) in 35 healthy men, and assessed the association between changes in amygdala functional connectivity and individual differences in neuroticism...
March 16, 2018: Behavioural Brain Research
Miao Wang, Yuxi Yang, Jian Xu, Wen Bai, Xueli Ren, Huijian Wu
BACKGROUND: The expression of circular RNA (circRNA) may affect tumor progression. However, there have been no systemic meta-analysis for cancer diagnosis by using circRNAs in clinical till now. Herein, we aimed to collect and examined all the evidence on the potential role of circRNA as novel biomarker in human cancers. METHODS: A comprehensive search strategy was used to search relevant literatures in the databases of PubMed, Embase, and the Web of Science from 2015 to August 2017...
March 20, 2018: BMC Cancer
Helen M Milojevich, Mary E Haskett
Parents are perhaps the most direct and profound influences on children's development of emotional competence. For example, how and what emotions parents express in the family has implications for children's ability to understand and regulate their emotions. What is less well understood is what potential environmental or contextual factors impact parents' emotional expressiveness, particularly in high-risk samples prone to atypical emotional expressiveness (e.g., deficits in the production and recognition of emotional expressions)...
January 2018: Journal of Child and Family Studies
Min Soo Choo, Jun Hyun Han, Jong Keun Kim, Tae Young Shin, Won Ki Lee, Sang Kon Lee, Seong Ho Lee
PURPOSE: We compared the outcomes of SWL to treat distal ureter stones with regard to the conventional prone and supine positions using the transgluteal approach through the greater sciatic foramen. METHODS: A prospective, randomized, single-blind, and multicenter study was conducted between October 2014 and July 2015. The inclusion criteria were radio-opaque distal ureter stones with a maximum diameter of 0.5-2 cm as measured on a CT scan. The included 160 patients were randomly assigned to two groups: the prone group (n = 80; treated in the conventional prone position) and the transgluteal group (n = 80; treated in the supine position using a transgluteal approach)...
March 16, 2018: World Journal of Urology
Shu-Hsien Chu, Keshab K Parhi, Christophe Lenglet
A joint structural-functional brain network model is presented, which enables the discovery of function-specific brain circuits, and recovers structural connections that are under-estimated by diffusion MRI (dMRI). Incorporating information from functional MRI (fMRI) into diffusion MRI to estimate brain circuits is a challenging task. Usually, seed regions for tractography are selected from fMRI activation maps to extract the white matter pathways of interest. The proposed method jointly analyzes whole brain dMRI and fMRI data, allowing the estimation of complete function-specific structural networks instead of interactively investigating the connectivity of individual cortical/sub-cortical areas...
March 16, 2018: Scientific Reports
Leslie K Allison, Tim Kiemel, John J Jeka
BACKGROUND AND PURPOSE: Multisensory reweighting (MSR) deficits in older adults contribute to fall risk. Sensory-challenge balance exercises may have value for addressing the MSR deficits in fall-prone older adults. The purpose of this study was to examine the effect of sensory-challenge balance exercises on MSR and clinical balance measures in fall-prone older adults. METHODS: We used a quasi-experimental, repeated-measures, within-subjects design. Older adults with a history of falls underwent an 8-week baseline (control) period...
April 2018: Journal of Neurologic Physical Therapy: JNPT
Dong-Eun Lee, Sang-Min Seo, Hee-Soon Woo, Sung-Yun Won
[Purpose] This study set out to substantiate the importance of the right sitting posture by measuring the sitting pressure. It also described the influence of an imbalanced sitting posture on the body. [Subjects and Methods] The subjects included 30 healthy adults. A pressure mapping system was used to measure the sitting pressure in the right, one side prone, chin propped, and slumped sitting positions. [Results] The WDI (XAP ) showed a statistically significant difference between the 3 incorrect postures (one side prone, chin propped, and slumped sitting) and the right sitting posture...
February 2018: Journal of Physical Therapy Science
Marco M Manni, Marion L Tiberti, Sophie Pagnotta, Hélène Barelli, Romain Gautier, Bruno Antonny
Phospholipid membranes form cellular barriers but need to be flexible enough to divide by fission. Phospholipids generally contain a saturated fatty acid (FA) at position sn1 whereas the sn2 -FA is saturated, monounsaturated or polyunsaturated. Our understanding of the impact of phospholipid unsaturation on membrane flexibility and fission is fragmentary. Here, we provide a comprehensive view of the effects of the FA profile of phospholipids on membrane vesiculation by dynamin and endophilin. Coupled to simulations, this analysis indicates that: (i) phospholipids with two polyunsaturated FAs make membranes prone to vesiculation but highly permeable; (ii) asymmetric sn1 -saturated- sn2 -polyunsaturated phospholipids provide a tradeoff between efficient membrane vesiculation and low membrane permeability; (iii) When incorporated into phospholipids, docosahexaenoic acid (DHA; omega-3) makes membranes more deformable than arachidonic acid (omega-6)...
March 15, 2018: ELife
Zhiguo Wang, Hai-Bo Fan, Wan-Wei Yang, Xiao-Dong Mao, Shu-Hang Xu, Xiao-Ping Ma, Gui-Ping Wan, Xiao-Ming Yao, Keyang Chen
AIMS/INTRODUCTION: To explore the relationship between plasma iron levels and gestational diabetes mellitus, as well as its impact on macrosomia. MATERIALS AND METHODS: We retrospectively compared ferritin level and other Characteristics between GDM gravidas and no-GDM gravidas. The correlation between the levels of plasma ferritin and glucose, Haemoglobin was explored. Meanwhile, we assessed the risk factors of macrosomia outcome. Furthermore, we explored the relationship between ferritin level and the incidence of macrosomia outcome...
March 14, 2018: Journal of Diabetes Investigation
Georges Hattab, Veit Wiesmann, Anke Becker, Tamara Munzner, Tim W Nattkemper
Time-lapse imaging of cell colonies in microfluidic chambers provides time series of bioimages, i.e., biomovies. They show the behavior of cells over time under controlled conditions. One of the main remaining bottlenecks in this area of research is the analysis of experimental data and the extraction of cell growth characteristics, such as lineage information. The extraction of the cell line by human observers is time-consuming and error-prone. Previously proposed methods often fail because of their reliance on the accurate detection of a single cell, which is not possible for high density, high diversity of cell shapes and numbers, and high-resolution images with high noise...
2018: Frontiers in Bioengineering and Biotechnology
Carol Cremin, Sarah Howard, Lyly Le, Aly Karsan, David F Schaeffer, Daniel Renouf, Kasmintan A Schrader
Background: Approximately 5% to 10% of pancreatic ductal adenocarcinoma (PDAC) has a hereditary basis. In most of these defined hereditary cancer syndromes, PDAC is not the predominant cancer type. Traditional criteria for publicly funded genetic testing typically require the presence of a set combination of the predominant syndrome-associated cancer types in the family history.We report the identification of a CDKN2A pathogenic variant in a PDAC-prone family without the cutaneous features of multiple moles or melanoma that are characteristic of the Familial Atypical Multiple Mole Melanoma (FAMMM) Syndrome identified in a universal testing algorithm for inherited mutations in pancreatic cancer patients...
2018: Hereditary Cancer in Clinical Practice
Thomas M Houslay, Maddalena Vierbuchen, Andrew J Grimmer, Andrew J Young, Alastair J Wilson
Within populations, individuals can vary in stress response, a multivariate phenomenon comprising neuroendocrine, physiological and behavioural traits.Verbal models of individual stress "coping style" have proposed that the behavioural component of this variation can be described as a single axis, with each individual's coping style being consistent across time and stress contexts.Focusing on this behavioural component of stress response and combining repeated measures of multiple traits with a novel multivariate modelling framework, we test for the existence of coping style variation and assess its stability across contexts in the Trinidadian guppy ( Poecilia reticulata )...
February 2018: Functional Ecology
Shigeru Kinoshita, Noriko Koizumi, Morio Ueno, Naoki Okumura, Kojiro Imai, Hiroshi Tanaka, Yuji Yamamoto, Takahiro Nakamura, Tsutomu Inatomi, John Bush, Munetoyo Toda, Michio Hagiya, Isao Yokota, Satoshi Teramukai, Chie Sotozono, Junji Hamuro
BACKGROUND: Corneal endothelial cell (CEC) disorders, such as Fuchs's endothelial corneal dystrophy, induce abnormal corneal hydration and result in corneal haziness and vision loss known as bullous keratopathy. We investigated whether injection of cultured human CECs supplemented with a rho-associated protein kinase (ROCK) inhibitor into the anterior chamber could increase CEC density. METHODS: We performed an uncontrolled, single-group study involving 11 persons who had received a diagnosis of bullous keratopathy and had no detectable CECs...
March 15, 2018: New England Journal of Medicine
Italo A Cavini, Claudia E Munte, Markus Beck Erlach, Thomas van Groen, Inga Kadish, Tao Zhang, Tamar Ziehm, Luitgard Nagel-Steger, Janine Kutzsche, Werner Kremer, Dieter Willbold, Hans Robert Kalbitzer
Pressure can shift the polymer-monomer equilibrium of Aβ, increasing pressure first leads to a release of Aβ-monomers, surprisingly at pressures higher than 180 MPa repolymerization is induced. By high pressure NMR spectroscopy, differences of partial molar volumes ΔV0 and compressibility factors Δβ' of polymerization were determined at different temperatures. The d-enantiomeric peptides RD2 and RD2D3 bind to monomeric Aβ with affinities substantially higher than those determined for fibril formation...
March 14, 2018: Chemical Communications: Chem Comm
Silvester Liposek, Natasa Zenic, Jose M Saavedra, Damir Sekulic, Jelena Rodek, Miha Marinsek, Dorica Sajber
Although coaching is considered an important determinant of athletes' potential doping behavior (PDB), there is an evident lack of studies that have examined coaching-strategy-and-training-methodology (CS&TM) in relation to PDB. This study was aimed to identify the specific associations that may exist between CS&TM -factors and other factors, and PDB in high-level swimming. The sample comprised 94 swimmers (35 females; 19.7 ± 2.3 years of age) and consisted of swimmers older than 18 years who participated in the 2017 National Championship...
March 2018: Journal of Sports Science & Medicine
W H Hou, P Wei, J L Xie, Y Y Zheng, Y L Zhang, X G Zhou
Objective: To investigate clinicopathological features and prognosis of tonsillar mantle cell lymphoma(TMCL). Methods: Clinical data of 25 patients with TMCL at Beijing Friendship Hospital, Capital Medical University from 2002 to 2016 were included. All the cases were reviewed microscopically. Various immunohistochemical stains were performed using the MaxVision two-step method. IgH/CCND1 gene fusion was detected by fluorescent in situ hybridization(FISH). Additionally, randomly selected 40 cases of non-tonsil MCL of the same period were compared...
March 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Michele Romoli, Paolo Eusebi, Sabrina Siliquini, Chiara Bedetti, Paolo Calabresi, Cinzia Costa
INTRODUCTION: Adverse events (AEs) of antiepileptic drugs (AEDs) affect patient compliance and dropout. No questionnaire measuring AEs of AEDs is available for Italian-speaking people with epilepsy. Moreover, no questionnaire has been shown to predict patient dropout. OBJECTIVE: The aim of this study was to provide a validated Italian version of the Liverpool Adverse Events Profile (iLAEP) and to define iLAEP reliability in AE monitoring and dropout risk prediction...
March 9, 2018: Epilepsy & Behavior: E&B
Mehdi Moini
In the past few years, there has been a significant effort by the forensic science community to develop new scientific techniques for the analysis of forensic evidence. Forensic chemists have been spearheaded to develop information-rich confirmatory technologies and techniques and apply them to a broad array of forensic challenges. The purpose of these confirmatory techniques is to provide alternatives to presumptive techniques that rely on data such as color changes, pattern matching, or retention time alone, which are prone to more false positives...
March 12, 2018: Electrophoresis
Ewa Juresic, Gary P Liney, Robba Rai, Joseph Descalar, Mark Lee, Karen Wong, Daniel Moses, Jacqueline Veera, Lois Holloway
INTRODUCTION: A magnetic resonance (MR) scanner for radiotherapy treatment simulation was commissioned in our department in June 2013. Practical set up and MR image quality trade-offs using a variety of patient positions and immobilisation devices routinely used in the treatment planning of rectal cancer patients were considered. The study also aimed to investigate the MR compatibility of the device materials with a focus on temperature changes during routine clinical examinations. METHODS: Ten volunteers were scanned: (1) Prone on a Civco Contoura Bellyboard (BBB), (2) Prone on a Civco MR Series Bellyboard (WBB), (3) Prone with no bellyboard and (4) Supine...
March 2018: Journal of Medical Radiation Sciences
Mahdieh Khodaei, Doug Hill, Rui Zheng, Lawrence H Le, Edmond H M Lou
PURPOSE: This study aimed to determine the intra- and inter-rater reliabilities of spinal flexibility measurements using ultrasound imaging on non-surgical candidates with adolescent idiopathic scoliosis (AIS). METHODS: Twenty-eight consecutive consented AIS subjects (25 F; 3 M) were recruited; 24 subjects' data were used for analysis. This study explored curve magnitude differences between standing, prone and voluntary maximum side-bending postures to assess the reliability of spinal flexibility (SF)...
March 9, 2018: European Spine Journal
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