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https://www.readbyqxmd.com/read/28531171/no-relevant-association-of-kinematic-gait-parameters-with-health-related-quality-of-life-in-parkinson-s-disease
#1
Kristina Bettecken, Felix Bernhard, Jennifer Sartor, Markus A Hobert, Marc Hofmann, Till Gladow, Janet M T van Uem, Inga Liepelt-Scarfone, Walter Maetzler
BACKGROUND: Health-related Quality of Life (HrQoL) is probably the most important outcome parameter for the evaluation and management of chronic diseases. As this parameter is subjective and prone to bias, there is an urgent need to identify objective surrogate markers. Gait velocity has been shown to be associated with HrQoL in numerous chronic diseases, such as Parkinson's disease (PD). With the development and wide availability of simple-to-use wearable sensors and sophisticated gait algorithms, kinematic gait parameters may soon be implemented in clinical routine management...
2017: PloS One
https://www.readbyqxmd.com/read/28528509/invasive-lobular-carcinoma-with-extracellular-mucin-production-a-novel-pattern-of-lobular-carcinomas-of-the-breast-clinico-pathological-description-of-eight-cases
#2
Gábor Cserni, Giuseppe Floris, Nektarios Koufopoulos, Anikó Kovács, Afroditi Nonni, Peter Regitnig, Anders Stahls, Zsuzsanna Varga
Invasive lobular carcinoma of the breast is known to produce intracellular mucin and has been recognized in single-case reports to show extracellular mucin production, as well. This latter morphology is not only rare but must also be under- or misdiagnosed. The aim was to better characterize this entity. Cases of lobular cancers demonstrating extracellular mucin formation were identified in a multi-institutional effort and their clinical and morphologic features were assessed. Immunohistochemistry was used to characterize the E-cadherin-membrane complex, neuroendocrine differentiation, and to some extent, mucin formation...
May 20, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28526445/the-effectiveness-of-adhesives-on-the-retention-of-mandibular-free-end-saddle-partial-dentures-an-in-vitro-study
#3
Daniel Quiney, Wayne Nishio Ayre, Paul Milward
OBJECTIVES: Existing in vitro methods for testing denture adhesives do not fully replicate the complex oral geometries and environment; and in vivo methods are qualitative, prone to bias and not easily reproducible. The purpose of this study was to develop a novel, quantitative and more accurate model to test the effect of adhesives on the retentive force of mandibular free end saddle partial dentures. METHODS: An in vitro model was developed based on an anatomically accurate cast of a clinical case...
May 16, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28523926/quantitative-evaluation-of-insulin-resistance-markers-in-pakistani-patients-suffering-from-hcv-associated-type-2-diabetes-mellitus
#4
S N Sabir, S Manzoor, F Parvaiz, M Saalim, E Ghani
The current study was designed to determine the role of the host genes involved in the development of chronic hepatitis C-associated type 2 diabetes mellitus. This study was carried out in patients in four different stages of chronic hepatitis C virus (HCV) infection, including treatment-naïve HCV patients, HCV-positive patients with type 2 diabetes mellitus (T2DM), non-responders and responders. The mRNA expression level of host genes, such as glucose-6-phosphatase (G6Pase), tumor necrosis factor α (TNF-α) and different adipokines including adiponectin, leptin and resistin, was quantified and compared to healthy controls...
2017: Acta Virologica
https://www.readbyqxmd.com/read/28522875/serum-uric-acid-is-associated-with-erectile-dysfunction-a-population-based-cross-sectional-study-in-chinese-men
#5
Fengbin Gao, Boren Jiang, Zhen Cang, Ningjian Wang, Bing Han, Qin Li, Yi Chen, Yingchao Chen, Fangzhen Xia, Hualing Zhai, Chi Chen, Meng Lu, Ying Meng, Yingli Lu, Zhoujun Shen
The role that serum uric acid (UA) plays in the pathophysiological development of erectile dysfunction (ED) is controversial. We aimed to screen the factors related with ED, and to examine the association between serum UA and ED. Our data were derived from a cross-sectional Survey on Prevalence in East China for Metabolic Diseases and Risk Factors study in 2014-2015. Questionnaire of International Index of Erectile Dysfunction-5 was used for assessment of ED. Data were collected in three general communities respectively...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28521353/intraoperative-angiography-for-arteriovenous-malformation-resection-in-the-prone-and-lateral-positions-using-upper-extremity-arterial-access
#6
Erez Nossek, David J Chalif, Razvan Buciuc, Eric J Gandras, Erich G Anderer, Sal Insigna, Amir R Dehdashti, Avi Setton
BACKGROUND: Intraoperative angiography is routinely utilized for aneurysms and arteriovenous malformations (AVMs) to verify complete occlusion and resection. Surgery for spinal and posterior fossa neurovascular lesions is usually performed in prone position. Intraoperative angiography in the prone position is challenging and there is no standardized protocol for this procedure. OBJECTIVE: To describe our experience with intraoperative angiography in the prone and lateral positions, using upper extremity arterial access...
June 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28515978/variation-in-medial-and-lateral-gastrocnemius-muscle-activity-with-foot-position
#7
Michael Cibulka, April Wenthe, Zach Boyle, Dylan Callier, Adam Schwerdt, Deidra Jarman, Michael J Strube
BACKGROUND: The gastrocnemius has two heads, medial gastrocnemius (MG) and lateral gastrocnemius (LG); little is known how they contract with different foot positions. The MG is more frequently strained than the LG; and gastrocnemius activation pattern altered by foot position may play a role in injury. Leg exercises often use a toe-in versus toe-out foot position to isolate one gastrocnemius head over another. PURPOSE: The purpose of this study was to determine the electromyographic gastrocnemius muscle activity in the toe-out and toe-in foot positions during weight bearing and non-weight bearing activities...
April 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28515962/analyses-of-publicly-available-genomics-resources-define-fgf-2-expressing-bladder-carcinomas-as-emt-prone-proliferative-tumors-with-low-mutation-rates-and-high-expression-of-ctla-4-pd-1-and-pd-l1
#8
Elizabeth A McNiel, Philip N Tsichlis
FGF-2 is overexpressed in a subset of invasive bladder carcinomas and its overexpression correlates with poor prognosis. Analyses of publicly available databases addressing the molecular mechanisms that may be responsible for the poor prognosis of these tumors, revealed that FGF-2 expression correlates positively with the expression of EMT-promoting transcription factors and with changes in gene expression that are characteristic of EMT. The same analyses also revealed that FGF-2 correlates negatively with the expression, mutation and copy number variations of FGFR-3, all of which are associated with non-invasive bladder carcinomas...
2017: Signal Transduction and Targeted Therapy
https://www.readbyqxmd.com/read/28514804/-changes-in-the-use-of-health-insurance-services-before-and-after-a-father-child-measure
#9
Felix Barre, Jelena Epping
Introduction Since 2002 inpatient preventive and rehabilitative measures for fathers and their children (F-C-M) are available in the German health system (§§ 24 and 41 SGB V). So far there is no data on health disorders of the fathers in F-C-M. The aim of this study is to examine whether participants of F-C-M are more prone to health problems than fathers who are not participating in F-C-M and whether participation in F-C-M contributes to improved health. To do so, the change in the use of outpatient care services is examined and compared to the use of mentioned services by fathers who are not participating in an F-C-M...
May 17, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28510799/practical-surgical-techniques-for-lymphadenectomy-along-the-right-recurrent-laryngeal-nerve-during-thoracoscopic-esophagectomy-in-the-prone-position
#10
Taro Oshikiri, Tetsu Nakamura, Yukiko Miura, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Kimihiro Yamashita, Yoshiko Matsuda, Takeru Matsuda, Yasuo Sumi, Satoshi Suzuki, Yoshihiro Kakeji
BACKGROUND: In esophageal squamous cell cancer (SCC), lymphadenectomy along the right recurrent laryngeal nerve (RLN) is important for disease control. The metastatic rate was 33% and the 5-year overall survival rate of these patients was 33.3%,1 but the risk of RLN palsy increases.2 We reported a reliable new method ('Pincers Maneuver')3 for lymphadenectomy along the right RLN during thoracoscopic esophagectomy in the prone position (TEP), and hereby present our video, aimed at providing a complete and safe dissection...
May 16, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28509261/management-of-fracture-dorso-lumbar-spine-in-a-pregnant-female-by-surgery-in-prone-position
#11
Dhiraj Vithal Sonawane, Pradip S Nemade, Ajay Chandanwale, Eknath Pawar, Sanjay A Jagtap
Surgical management of thoraco-lumbar spine fracture in pregnancy has specific concerns during surgery like positioning, approach, and radiation exposure to fetus. We report a case of burst fracture of 12th thoracic vertebrae with paraplegia in a young female with 26 weeks of gestation. Surgery was performed in prone position on a Toronto frame. This report also discusses the management of thoraco-lumbar spine fracture in pregnancy with review of literature.
May 16, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28506958/enhancing-comparative-effectiveness-research-with-automated-pediatric-pneumonia-detection-in-a-multi-institutional-clinical-repository-a-phis-pilot-study
#12
Stephane Meystre, Ramkiran Gouripeddi, Joel Tieder, Jeffrey Simmons, Rajendu Srivastava, Samir Shah
BACKGROUND: Community-acquired pneumonia is a leading cause of pediatric morbidity. Administrative data are often used to conduct comparative effectiveness research (CER) with sufficient sample sizes to enhance detection of important outcomes. However, such studies are prone to misclassification errors because of the variable accuracy of discharge diagnosis codes. OBJECTIVE: The aim of this study was to develop an automated, scalable, and accurate method to determine the presence or absence of pneumonia in children using chest imaging reports...
May 15, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28506824/hypoxia-and-nicotine-effects-on-pituitary-adenylate-cyclase-activating-polypeptide-pacap-and-its-receptor-1-pac1-in-the-developing-piglet-brainstem
#13
J Huang, K A Waters, R Machaalani
Pituitary adenylate cyclase activating polypeptide (PACAP) and its cognate receptor 1 (PAC1), have been implicated in the pathophysiology of the Sudden Infant Death Syndrome (SIDS). Two main risk factors for SIDS are prone sleeping and cigarette smoke exposure. Using piglet models of these risk factors, intermittent hypercapnic hypoxia (IHH-mimicking rebreathing in prone position) and nicotine (main reinforcing element of cigarettes), this study aimed to determine their effects on PACAP and PAC1 protein expression in the medulla...
May 12, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28502024/the-relationship-between-religious-beliefs-and-quality-of-life-among-patients-with-multiple-sclerosis
#14
Fatemeh Vizehfar, Azita Jaberi
Patients with chronic diseases, such as multiple sclerosis (MS), are prone to emotional distresses and reduction in life quality more than others. This study aimed to assess the relationship between religious beliefs and quality of life among patients with MS. In this study, 145 MS patients completed 36-Item Short-Form Health Survey (SF-36) and the Duke University Religion Index (DUREL) questionnaires. The results indicated that unorganized religious activities were significantly associated with marital status and education level...
May 13, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28500585/systematic-review-and-meta-analysis-of-complications-and-mortality-of-veno-venous-extracorporeal-membrane-oxygenation-for-refractory-acute-respiratory-distress-syndrome
#15
REVIEW
Sergi Vaquer, Candelaria de Haro, Paula Peruga, Joan Carles Oliva, Antonio Artigas
Veno-venous extracorporeal membrane oxygenation (ECMO) for refractory acute respiratory distress syndrome (ARDS) is a rapidly expanding technique. We performed a systematic review and meta-analysis of the most recent literature to analyse complications and hospital mortality associated with this technique. Using the PRISMA guidelines for systematic reviews and meta-analysis, MEDLINE and EMBASE were systematically searched for studies reporting complications and hospital mortality of adult patients receiving veno-venous ECMO for severe and refractory ARDS...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28499865/implication-of-altered-autonomic-control-for-orthostatic-tolerance-in-sci
#16
REVIEW
Jill Maria Wecht, William A Bauman
Neural output from the sympathetic and parasympathetic branches of the autonomic nervous system (ANS) are integrated to appropriately control cardiovascular responses during routine activities of daily living including orthostatic positioning. Sympathetic control of the upper extremity vasculature and the heart arises from the thoracic cord between T1 and T5, whereas splanchnic bed and lower extremity vasculature receive sympathetic neural input from the lower cord between segments T5 and L2. Although the vasculature is not directly innervated by the parasympathetic nervous system, the SA node is innervated by post-ganglionic vagal nerve fibers via cranial nerve X...
May 3, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28497577/the-least-speciose-amongst-the-most-speciose-natural-history-correlates-of-mono-and-bispecific-genera-of-rodentia-and-soricomorpha
#17
Giovanni Amori, Alessandra Maria Bissattini, Spartaco Gippoliti, Leonardo Vignoli, Luigi Maiorano, Luca Luiselli
Mono-and bispecific genera are of special concern as they represent unique phylogenetic/evolutionary trajectories within larger clades. In addition, as phylogenetically older taxa are supposed to be exposed to higher rarity and extinction risk, mono- and bispecific genera may be intrinsically more prone to extinction risks than multispecies genera, although extinction risks also depend on the ecological and biological strategy of the species. Here, the distribution across biogeographical zones and the threatening levels of two speciose orders of mammals (mono- and bispecific genera of Rodentia and Soricomorpha) are investigated in order to highlight major patterns at the worldwide scale...
May 11, 2017: Integrative Zoology
https://www.readbyqxmd.com/read/28496194/zooplankton-community-profiling-in-a-eutrophic-freshwater-ecosystem-lake-tai-basin-by-dna-metabarcoding
#18
Jianghua Yang, Xiaowei Zhang, Yuwei Xie, Chao Song, Yong Zhang, Hongxia Yu, G Allen Burton
Communities of zooplankton, a critical portion of aquatic ecosystems, can be adversely affected by contamination resulting from human activities. Understanding the influence of environmental change on zooplankton communities under field-conditions is hindered by traditional labor-intensive approaches that are prone to taxonomic and enumeration mistakes. Here, metabarcoding of cytochrome c oxidase I (COI) region of mitochondrial DNA was used to characterize the genetic diversity of zooplankton. The species composition of zooplankton communities determined by metabarcoding was consistent with the results based on the traditional morphological approach...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28496141/a-randomized-comparison-of-the-prone-ventilation-endotracheal-tube-versus-the-traditional-endotracheal-tube-in-adult-patients-undergoing-prone-position-surgery
#19
Wangyuan Zou, Jiali Shao, Xia Liang, Lin Li, Zhenghua He, Qulian Guo
Endotracheal tube displacement or dislocation is a severe complication that can occur in patients who require prone position ventilation. We hypothesized the prone position tube (PPT) would reduce the incidence of displacement of an endotracheal tube in an adult prone operation compared to a traditional tube (TT). A total of 80 adult patients undergoing neurosurgery or spine surgery were recruited. Sixty patients with prone position ventilation were randomly divided into the traditional routine endotracheal tube group (Group TT, n = 30) and the prone position ventilation endotracheal tube group (Group PPT, n = 30)...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28494440/nuclear-architecture-of-mouse-spermatocytes-chromosome-topology-heterochromatin-and-nucleolus
#20
Soledad Berrios
The nuclear organization of spermatocytes in meiotic prophase I is primarily determined by the synaptic organization of the bivalents that are bound by their telomeres to the nuclear envelope and described as arc-shaped trajectories through the 3D nuclear space. However, over this basic meiotic organization, a spermatocyte nuclear architecture arises that is based on higher-ordered patterns of spatial associations among chromosomal domains from different bivalents that are conditioned by the individual characteristics of chromosomes and the opportunity for interactions between their domains...
May 12, 2017: Cytogenetic and Genome Research
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