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https://www.readbyqxmd.com/read/29161772/microarray-analysis-of-gene-expression-in-the-cyclooxygenase-cox-knockout-mice-a-connection-to-autism-spectrum-disorder
#1
Ravneet Rai-Bhogal, Eizaaz Ahmad, Hongyan Li, Dorota A Crawford
The cellular and molecular events that take place during brain development play an important role in governing function of the mature brain. Lipid signalling molecules such as prostaglandin E2 (PGE2 ) play an important role in healthy brain development. Abnormalities along the COX/PGE2 signalling pathway due to genetic or environmental causes have been linked to Autism Spectrum Disorders (ASDs). This study aims to evaluate the effect of altered COX/PGE2 signalling on development and function of the prenatal brain using male mice lacking cyclooxygenase-1 and -2 (COX-1(-/-) and COX-2(-/-) ) as potential model systems of ASD...
November 21, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29161771/tetramethylpyrazine-nitrone-activates-akt-creb-through-increasing-bdnf-expression-to-promote-post-ischemic-neuroregeneration-and-recovery-of-neurological-functions-in-rats
#2
Gaoxiao Zhang, Tao Zhang, Ning Li, Liangmiao Wu, Jianbo Gu, Cuimei Li, Chen Zhao, Wei Liu, Luchen Shan, Pei Yu, Xifei Yang, Yaohui Tang, Guo-Yuan Yang, Yuqiang Wang, Yewei Sun, Zaijun Zhang
BACKGROUND AND PURPOSE: Neuronal regeneration from endogenous precursors is an attractive strategy for the treatment of ischemic stroke; however, most stroke-generated new born neurons die over time. Therefore, a drug that is both neuroprotective and pro-neurogenic may be promising. In this study, we assessed the neurogenic and oligodendrogenic effects of tetramethylpyrazine nitrone (TBN), a neuroprotective drug candidate for stroke, in a rat model of ischemic stroke. EXPERIMENTAL APPROACH: Sprague Dawley (SD) rats were subjected to middle cerebral artery occlusion (MCAO)...
November 21, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29161765/mir-335-inhibited-cell-proliferation-of-lung-cancer-cells-by-target-tra2%C3%AE
#3
Jian Liu, Tingting Bian, Jia Feng, Li Qian, Jianguo Zhang, Daishan Jiang, Qing Zhang, Xiaoli Li, Yifei Liu, Jiahai Shi
Accumulating evidence has suggested that the dysregulation of miRNAs is an important factor in the pathogenesis of lung cancer. Here, we demonstrate that miR-335 expression is reduced in non-small cell lung cancer (NSCLC) tumors relative to non-cancerous adjacent tissues, whilst the expression of Tra2β is increased. In addition, clinical data revealed that the increased Tra2β and decreased miR-335 expression observed in NSCLC cells was associated with poor patient survival rates. In-vitro experimentation showed that the overexpression of miR-335 inhibited the growth, invasion and migration capabilities of A459 lung cancer cells, by targeting Tra2β...
November 21, 2017: Cancer Science
https://www.readbyqxmd.com/read/29161719/palmitic-acid-curcumin-ester-facilitates-protection-of-neuroblastoma-against-oligomeric-a%C3%AE-40-insult
#4
Zhangyang Qi, Meihao Wu, Yun Fu, Tengfei Huang, Tingting Wang, Yanjie Sun, Zhibo Feng, Changzheng Li
BACKGROUND/AIMS: The generation of reactive oxygen species (ROS) caused by amyloid-β (Aβ) is considered to be one of mechanisms underlying the development of Alzheimer's disease. Curcumin can attenuate Aβ-induced neurotoxicity through ROS scavenging, but the protective effect of intracellular curcumin on neurocyte membranes against extracellular Aβ may be compromised. To address this issue, we synthesized a palmitic acid curcumin ester (P-curcumin) which can be cultivated on the cell membrane and investigated the neuroprotective effect of P-curcumin and its interaction with Aβ...
November 20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29161708/association-between-childhood-obesity-and-neighbourhood-accessibility-to-fast-food-outlets-a-nationwide-6-year-follow-up-study-of-944-487-children
#5
Tsuyoshi Hamano, Xinjun Li, Jan Sundquist, Kristina Sundquist
OBJECTIVES: The aim of this 6-year follow-up study was to examine whether neighbourhood accessibility to fast-food outlets was associated with diagnosed childhood obesity, after adjustment for neighbourhood- and individual-level socio-demographic factors. METHODS: This 6-year follow-up study comprised 484,677 boys and 459,810 girls aged 0-14 years in Sweden. The follow-up period ran from January 1, 2005, until hospitalisation/out-patient treatment for obesity, death, emigration or the end of the study period on December 31, 2010...
November 22, 2017: Obesity Facts
https://www.readbyqxmd.com/read/29161705/maintained-folic-acid-supplementation-reduces-the-risk-of-mortality-in-continuous-ambulatory-peritoneal-dialysis-patients
#6
Rong Rong, Qian Zhou, Jianxiong Lin, Naya Huang, Wei Li, Yagui Qiu, Xueqing Yu, Haiping Mao
BACKGROUND: The association between folic acid (FA) supplementation and mortality in continuous ambulatory peritoneal dialysis (CAPD) patients is unclear. METHODS: FA exposure was calculated as a percentage of cumulative duration of drug usage to total follow-up duration (FA%). A total of 1,358 patients were classified by a cutoff value of FA%. The association of FA with mortality was evaluated using Cox proportional hazards models. RESULTS: The cutoff value of FA% for predicting mortality was <34% at a median follow-up of 40...
November 22, 2017: Blood Purification
https://www.readbyqxmd.com/read/29161702/favorable-effects-of-endoscopic-ligation-combined-with-drugs-on-rebleeding-and-mortality-in-cirrhotic-patients-a-network-meta-analysis
#7
Liang Shi, Xueping Zhang, Jianye Li, Xibo Bai
BACKGROUND: To assess the effects of combination therapies (endoscopic plus drug[s], drug combinations) on variceal/any-cause rebleeding and mortality among cirrhotic patients with one previous episode of variceal hemorrhage. SUMMARY: We searched PubMed, Embase, Cochrane Library, and Web of Science for eligible studies. We included 26 randomized controlled trials involving 2,536 adults using OR to measure the effects. Endoscopic variceal ligation (EVL) plus nadolol ranked first for reducing recurrent bleeds...
November 21, 2017: Digestive Diseases
https://www.readbyqxmd.com/read/29161696/the-protein-expression-level-of-a-heterogeneous-gene-inserted-in-lipi-1-of-the-listeria-ivanovii-genome-relies-on-its-insertion-orientation
#8
Sijing Liu, Mingjuan Jiang, Lin Su, Tian Tang, Xiang Zhang, Yongyu Li, Qikang Pu, Chenyan Ren, Chuan Wang
Due to its capability to multiply in either phagocytic or nonphagocytic cells, and to subsequently elicit a robust cellular immune response, Listeria ivanovii (LI) is thought to be feasible for developing bacteria-based live attenuated vaccines. We previously generated several recombinant LI strains expressing Mycobacterium tuberculosis antigens. Since the expression level of heterogeneous protein was sometimes very low, we attempted to elucidate the principle of heterogeneous protein expression in such recombinant LI strains...
November 22, 2017: Journal of Molecular Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29161695/a-randomized-controlled-trial-of-comparing-ultrasound-guided-transversus-abdominis-plane-block-with-local-anesthetic-infiltration-in-peritoneal-dialysis-catheter-implantation
#9
Qi Li, Xiaohong Tang, Tian Tao, Wenjuan Zhang, Wei Qin, Jie Zhang, Zi Li
BACKGROUND: The ultrasound-guided transversus abdominis plane (TAP) block has been demonstrated as a useful analgesia technique in lower-abdomen surgeries. We hypothesized that it could be the principal anesthesia technique for end-stage renal disease (ESRD) patients undergoing peritoneal dialysis (PD) catheter (PDC) implantation using the open dissection method. METHODS: This was a single-center, prospective, randomized, and double-blinded study. All eligible patients were randomized into 2 groups: the TAP block group (n = 20) and the local anesthetic infiltration (LAI) group (n = 20)...
November 22, 2017: Blood Purification
https://www.readbyqxmd.com/read/29161662/deiodination-of-iopamidol-by-zero-valent-iron-zvi-enhances-formation-of-iodinated-disinfection-by-products-during-chloramination
#10
Huiyu Dong, Zhimin Qiang, Junfeng Lian, Jin Li, Jianwei Yu, Jiuhui Qu
Iodinated X-ray contrast media (ICM) is considered as one of iodine sources for formation of toxic iodinated disinfection byproducts (I-DBPs) during disinfection. This study investigated transformation of a typical ICM, iopamidol (IPM) by zero valent iron (ZVI) and the effect of transformation on the formation of I-DBPs during chloramination. It was found that the presence of ZVI could deiodinate IPM into I(-) and the transformation of IPM exhibited a pseudo-first-order kinetics. Acidic circumstance, SO4(2-), Cl(-) and monochloramine could promote the transformation of IPM by ZVI, while SiO3(2-) inhibited the transformation of IPM...
November 14, 2017: Water Research
https://www.readbyqxmd.com/read/29161661/chlorogenic-acid-prevents-diabetic-nephropathy-by-inhibiting-oxidative-stress-and-inflammation-through-modulation-of-the-nrf2-ho-1-and-nf-%C3%A4-b-pathways
#11
Liping Bao, Jushuang Li, Dongqing Zha, Lian Zhang, Ping Gao, Tao Yao, Xiaoyan Wu
Oxidative and inflammatory damage have been suggested to play important roles in the pathogenesis of diabetic nephropathy (DN). Chlorogenic acid (CGA) is one of the most abundant polyphenols and has known immunoprotective, antioxidant and anti-inflammatory properties. In the present study, animal experiments were designed to examine the protective effects of CGA in DN, and cellular experiments were designed to explore the underlying mechanisms. CGA significantly attenuated diabetic renal damage based on histological pathology and molecular biological methods...
November 18, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29161646/antimicrobial-colloidal-hydrogels-assembled-by-graphene-oxide-and-thermo-sensitive-nanogels-for-cell-encapsulation
#12
Wenhua Cheng, Yunhua Chen, Lijing Teng, Bingheng Lu, Li Ren, Yingjun Wang
Hydrogels are promising 3D materials that have demonstrated increasing applications in the encapsulation and delivery of drugs and cells. Herein we report an injectable colloidal hydrogel that directly assembled by graphene oxide (GO) and thermo-sensitive nanogels (tNG). The pH dependent hydrogen bonding interactions between the carboxyl and oxethyl groups induce the reversible assembly of GO and nanogels. The hydrogel is mouldable and can be shaped into different macroscopic objects, and the mechanical strengths are tunable with pH and temperature adjustment...
November 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29161632/ambient-air-pollution-adipokines-and-glucose-homeostasis-the-framingham-heart-study
#13
Wenyuan Li, Kirsten S Dorans, Elissa H Wilker, Mary B Rice, Itai Kloog, Joel D Schwartz, Petros Koutrakis, Brent A Coull, Diane R Gold, James B Meigs, Caroline S Fox, Murray A Mittleman
OBJECTIVE: To examine associations of proximity to major roadways, sustained exposure to fine particulate matter (PM2.5), and acute exposure to ambient air pollutants with adipokines and measures of glucose homeostasis among participants living in the northeastern United States. METHODS: We included 5958 participants from the Framingham Offspring cohort examination cycle 7 (1998-2001) and 8 (2005-2008) and Third Generation cohort examination cycle 1 (2002-2005) and 2 (2008-2011), who did not have type 2 diabetes at the time of examination visit...
November 18, 2017: Environment International
https://www.readbyqxmd.com/read/29161627/nanoscaled-red-blood-cells-facilitate-breast-cancer-treatment-by-combining-photothermal-photodynamic-therapy-and-chemotherapy
#14
Guoyun Wan, Bowei Chen, Ling Li, Dan Wang, Shurui Shi, Tao Zhang, Yue Wang, Lianyun Zhang, Yinsong Wang
Red blood cells (RBCs)-based vesicles have been widely used for drug delivery due to their unique advantages. Intact RBCs contain a large amount of oxyhemoglobin (oxyHb), which can assist with photodynamic therapy (PDT). Indocyanine green (ICG), a photosensitizer both for photothermal therapy (PTT) and PDT, shows potent anticancer efficacy when combined with chemotherapeutic drug doxorubicin (DOX). In this study, we prepared nanoscaled RBCs (RAs) containing oxyHb and gas-generating agent ammonium bicarbonate (ABC) for co-loading and controlled release of ICG and DOX, thus hoping to achieve synergistic effects of PTT/PDT and chemotherapy against breast cancer...
November 14, 2017: Biomaterials
https://www.readbyqxmd.com/read/29161598/roles-and-potential-mechanisms-of-selenium-in-countering-thyrotoxicity-of-dehp
#15
Pei Zhang, Xie Guan, Min Yang, Li Zeng, Changjiang Liu
Di-(2-ethylhexyl) phthalate (DEHP) as a ubiquitous environmental contaminant could disturb thyroid hormone (TH) homeostasis. Selenium as an essential trace element has protective effects on thyroids. To verify roles of selenium in countering thyrotoxicity of DEHP and elucidate potential mechanisms, Sprague-Dawley rats and Nthy-ori 3-1 cells were treated with DEHP or/and selenomethionine (SeMet). Results showed that selenium supplementation elevated plasma free thyroxine (FT4) that was decreased by DEHP, and free triiodothyronine (FT3) and thyroid stimulating hormone (TSH) levels were also partially recovered...
November 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29161570/acclimation-of-acid-tolerant-methanogenic-propionate-utilizing-culture-and-microbial-community-dissecting
#16
Ying Li, Yongming Sun, Lianhua Li, Zhenhong Yuan
The acid-tolerant methanogenic propionate degradation culture was acclimated in a propionate-fed semi-continuous bioreactor by daily adjusting the digestate pH. The performance of propionate fermentation, the respond of microbial community structure to the acidic environment, and the microbial network for propionate degradation in the acid-tolerant culture was investigated. The results demonstrated that after long term of acclimation to low pH, the digester could produce methane from propionate at pH 4.8-5...
November 13, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29161569/denitrification-of-landfill-leachate-under-different-hydraulic-retention-time-in-a-two-stage-anoxic-oxic-combined-membrane-bioreactor-process-performances-and-bacterial-community
#17
Jianbo Liu, Panyue Zhang, Haibo Li, Yuan Tian, Siyu Wang, Yonghui Song, Guangming Zeng, Chen Sun, Zhiyong Tian
Two-stage anoxic/oxic combined membrane bioreactor (A/O-A/O-MBR) process was used to treat leachate generated from Shenyang Laohuchong landfill, and the effect of hydraulic retention time (HRT) was studied. A long HRT of 9 d and a short HRT of 5 d showed negative effect on the stability of process, resulting in a higher organic concentration of effluent than that with a HRT of 7 d, while the highest removal of chemical oxygen demand (COD), ammonia (NH4(+)-N) and total nitrogen (TN) were achieved with a HRT of 7 d, which was 82...
November 11, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29161534/omics-and-bioinformatics-time-for-new-data-analysis-approaches
#18
Chenyu Li, Wei Jiang, Yan Xu
No abstract text is available yet for this article.
November 21, 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29161513/insights-into-molecular-basis-of-acute-contact-toxicity-of-diverse-organic-chemical-in-honey-bee
#19
Xiao Li, Yuan Zhang, Hongna Chen, Huanhuan Li, Yong Zhao
The chemical pollutants, including pesticides and other industrial chemicals, have resulted in significant risks to the whole ecosystem. Therefore, the ecological risk assessment of chemicals is vital and necessary. Since honey bee (Apis mellifera) is probably among the most exposed species to the polluting chemicals, we focused on the in silico estimation of honey bee toxicity (HBT) of chemical and the analysis of the relevance of chemical HBT and several key physical-chemical properties and structural characteristics...
November 21, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29161512/trophodynamics-of-organic-pollutants-in-pelagic-and-benthic-food-webs-of-lake-dianchi-importance-of-ingested-sediment-as-uptake-route
#20
Senrong Fan, Beili Wang, Hang Liu, Shixiong Gao, Tong Li, Shuran Wang, Yong Liu, Xueqin Liu, Yi Wan
Habitat is of great importance in determining the trophic transfer of pollutants in freshwater ecosystems; however, the major factors influencing chemical trophodynamics in pelagic and benthic food webs remain unclear. This study investigated the levels of p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), polycyclic aromatic hydrocarbons (PAHs), and substituted PAHs (s-PAHs) in two plankton species, six invertebrate species, and ten fish species collected from Lake Dianchi in southern China. Relatively high concentrations of PAHs and s-PAHs were detected with total concentrations of 11...
November 21, 2017: Environmental Science & Technology
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