keyword
MENU ▼
Read by QxMD icon Read
search

Caloric restriction

keyword
https://www.readbyqxmd.com/read/29665986/prevention-and-treatment-of-type-2-diabetes-a-pathophysiological-based-approach
#1
REVIEW
Dorit Samocha-Bonet, Sophie Debs, Jerry R Greenfield
Prediabetes affects approximately 40% of American adults. Randomized trials report that a proportion of individuals with prediabetes develop diabetes despite caloric restriction, physical activity, and/or when treated with metformin, the first-line medication for patients with type 2 diabetes mellitus (T2DM). Currently, there are no valid predictors of the effectiveness of these measures in determining who will and who will not progress to the T2DM state. Few studies have examined the clinical and phenotypic predictors of better and worse glycemic response to lifestyle interventions and metformin in prediabetes and diabetes...
April 14, 2018: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29662634/caloric-restriction-delays-yeast-chronological-aging-by-remodeling-carbohydrate-and-lipid-metabolism-altering-peroxisomal-and-mitochondrial-functionalities-and-postponing-the-onsets-of-apoptotic-and-liponecrotic-modes-of-regulated-cell-death
#2
Anthony Arlia-Ciommo, Anna Leonov, Adam Beach, Vincent R Richard, Simon D Bourque, Michelle T Burstein, Pavlo Kyryakov, Alejandra Gomez-Perez, Olivia Koupaki, Rachel Feldman, Vladimir I Titorenko
A dietary regimen of caloric restriction delays aging in evolutionarily distant eukaryotes, including the budding yeast Saccharomyces cerevisiae . Here, we assessed how caloric restriction influences morphological, biochemical and cell biological properties of chronologically aging yeast advancing through different stages of the aging process. Our findings revealed that this low-calorie diet slows yeast chronological aging by mechanisms that coordinate the spatiotemporal dynamics of various cellular processes before entry into a non-proliferative state and after such entry...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29652545/strategies-for-optimal-cardiovascular-aging
#3
Douglas R Seals, Vienna E Brunt, Matthew J Rossman
This review summarizes the opening keynote presentation overview of the American Physiological Society conference on Cardiovascular Aging: New Frontiers and Old Friends held in Westminster, CO, in August 2017. Age is the primary risk factor for cardiovascular diseases (CVD). Without effective intervention, increased numbers of older adults in the future will translate to greater prevalence of CVD and related disorders. Advancing age increases the risk of CVD partly via direct effects on the heart and through increases in blood pressure; however, much of the risk is mediated by arterial dysfunction, including large elastic artery stiffening and both macro- and micro-vascular endothelial dysfunction...
April 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29651021/sustained-caloric-restriction-in-health
#4
Ivone Leong
No abstract text is available yet for this article.
April 12, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29626394/microbiome-and-health-ramifications-of-intelligent-deception
#5
George B Stefano, Rachel Fine, Richard M Kream
Ten thousand years ago, the foundation for agricultural development and animal domestication was laid. Neolithic founder crops were carbohydrate-laden cereal grasses that facilitated transformation of hunter-gather societies into ancient civilizations with realistic capabilities for population expansion. In the last 3-4 decades, however, debilitating medical consequences of a progressively narrowed high caloric diet incorporating processed carbohydrates, animal protein, saturated fat and cholesterol, are translated into a global epidemic of obesity linked to metabolic and endocrine disorders, which, in part, emerged from the enhancement of our longevity...
April 7, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29618011/effects-of-diazoxide-mediated-insulin-suppression-on-glucose-and-lipid-metabolism-in-non-diabetic-obese-men
#6
Sandra Loves, Lenneke van Groningen, Margreet Filius, Marja Mekking, Tom Brandon, Cees J Tack, Ad Hermus, Hans de Boer
Introduction: It has been suggested that stimulation of lipolysis by Diazoxide (DZX)-mediated insulin suppression may be useful as a treatment of obesity. However, the optimal dose to promote lipolysis without causing hyperglycemia is currently unknown. Aim: To assess the effects of DZX in non-diabetic obese men on lipid and glucose metabolism. Methods: Double-blind, placebo-controlled, 6-month trial in men with a BMI of 30 - 37.5 kg/m2 treated with a combination of caloric restriction, a standardized exercise program, and DZX or placebo dose escalation...
March 29, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29616249/anti-aging-potential-of-tree-nuts-with-a-focus-on-the-phytochemical-composition-molecular-mechanisms-and-thermal-stability-of-major-bioactive-compounds
#7
REVIEW
Marius Emil Rusu, Ana-Maria Gheldiu, Andrei Mocan, Laurian Vlase, Daniela-Saveta Popa
Tree nuts, complete functional foods, contain macro- and micronutrients of high biological value. These bioactive compounds have a synergistic effect in preventing and delaying many age-related pathologies (e.g. cardiovascular diseases, stroke, type 2 diabetes mellitus, certain types of cancer, and several neurodegenerative diseases). Tree nuts are low in carbohydrates, but they abound in healthy fatty acids, in optimal proportion for a good plasma lipid profile, and are a good source of proteins, rich in proteinogenic amino acids...
April 4, 2018: Food & Function
https://www.readbyqxmd.com/read/29605816/regulation-of-kynurenine-metabolism-by-a-ketogenic-diet
#8
Svenja Heischmann, Lindsey B Gano, Kevin Quinn, Li-Ping Liang, Jacek Klepacki, Uwe Christians, Nichole Reisdorph, Manisha Patel
Ketogenic diets (KDs) are increasingly utilized as treatments for epilepsy, other neurological diseases, and cancer. Despite their long history in suppressing seizures, the distinct molecular mechanisms of action of KDs are still largely unknown. The goal of this study was to identify key metabolites and pathways altered in hippocampus and plasma of rats fed a KD vs. control diet either ad libitum or calorically restricted to 90% of the recommended intake. This was accomplished using a combination of targeted methods and untargeted mass spectrometry-based metabolomics analyses...
March 31, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29597027/natural-products-with-anti-aging-potential-affected-targets-and-molecular-mechanisms
#9
REVIEW
Cristina-Sorina Cătană, Nikolay Mehterov, Atanas G Atanasov, Ioana Berindan-Neagoe
In recent years, there has been a great deal of attention toward the molecular machinery relevant to age-related progression controlled through the external intervention of polyphenols- an epigenetic-modulating diet. Natural products modulate cellular longevity through histone post-translational modification and can also induce the upregulation of autophagy, thus reducing the level of acetyl coenzyme A (AcCoA). In addition, the effect of caloric restriction (CR) on cancer-related chronic inflammation is of great significance in aging...
March 26, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29596307/resistance-training-prevents-muscle-loss-induced-by-caloric-restriction-in-obese-elderly-individuals-a-systematic-review-and-meta-analysis
#10
REVIEW
Amanda V Sardeli, Tiemy R Komatsu, Marcelo A Mori, Arthur F Gáspari, Mara Patrícia T Chacon-Mikahil
It remains unclear as to what extent resistance training (RT) can attenuate muscle loss during caloric restriction (CR) interventions in humans. The objective here is to address if RT could attenuate muscle loss induced by CR in obese elderly individuals, through summarized effects of previous studies. Databases MEDLINE, Embase and Web of Science were used to perform a systematic search between July and August 2017. Were included in the review randomized clinical trials (RCT) comparing the effects of CR with (CRRT) or without RT on lean body mass (LBM), fat body mass (FBM), and total body mass (BM), measured by dual-energy X-ray absorptiometry, on obese elderly individuals...
March 29, 2018: Nutrients
https://www.readbyqxmd.com/read/29595117/non-alcoholic-fatty-pancreas-disease-nafpd-a-silent-spectator-or-the-fifth-component-of-metabolic-syndrome-a-literature-review
#11
Bhupinder Romana, Harleen Chela, Francis Dailey, Fatiha Nassir, Veysel Tahan
Fat accumulation in the pancreas has remained a relatively unknown disease since it was initially described in 1933. However, it has gained increasing attention in the past two decades with the emergence of the obesity epidemic. Pancreatic steatosis is a general term used for fat accumulation in the pancreas. It is further classified into fatty replacement, fatty infiltration, lipomatous pseudo-hypertrophy, non-alcoholic fatty pancreas disease (NAFPD) and non-alcoholic fatty steatopancreatitis (NASP). NAFPD is defined as obesity-associated accumulation of fat in the pancreas without significant alcohol consumption...
March 27, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29593595/how-does-food-taste-in-anorexia-and-bulimia-nervosa-a-protocol-for-a-quasi-experimental-cross-sectional-design-to-investigate-taste-aversion-or-increased-hedonic-valence-of-food-in-eating-disorders
#12
David Garcia-Burgos, Sabine Maglieri, Claus Vögele, Simone Munsch
Background: Despite on-going efforts to better understand dysregulated eating, the olfactory-gustatory deficits and food preferences in eating disorders (ED), and the mechanisms underlying the perception of and responses to food properties in anorexia nervosa (AN) and bulimia nervosa (BN) remain largely unknown; both during the course of the illness and compared to healthy populations. It is, therefore, necessary to systematically investigate the gustatory perception and hedonics of taste in patients with AN and BN...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29593493/low-fat-diet-with-caloric-restriction-reduces-white-matter-microglia-activation-during-aging
#13
Zhuoran Yin, Divya D Raj, Wandert Schaafsma, Roel A van der Heijden, Susanne M Kooistra, Aaffien C Reijne, Xiaoming Zhang, Jill Moser, Nieske Brouwer, Peter Heeringa, Chun-Xia Yi, Gertjan van Dijk, Jon D Laman, Erik W G M Boddeke, Bart J L Eggen
Rodent models of both aging and obesity are characterized by inflammation in specific brain regions, notably the corpus callosum, fornix, and hypothalamus. Microglia, the resident macrophages of the central nervous system, are important for brain development, neural support, and homeostasis. However, the effects of diet and lifestyle on microglia during aging are only partly understood. Here, we report alterations in microglia phenotype and functions in different brain regions of mice on a high-fat diet (HFD) or low-fat diet (LFD) during aging and in response to voluntary running wheel exercise...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29589340/influence-of-nutritional-status-on-the-absorption-of-polyphyllin-i-an-anticancer-candidate-from-paris-polyphylla-in-rats
#14
Feng-Ling Yu, Wei-Liang Gong, Fang-Jiang Xu, Jun-Wen Wu, Shailendra Shakya, He Zhu
BACKGROUND AND OBJECTIVES: Protein-calorie malnutrition (PCM) is one of the most suffered complications in cancer patients. Polyphyllin I (PPI), a saponin isolated from rhizome of Paris polyphylla, is a potential candidate in cancer therapy. In this study, the influence of nutritional status on the absorption of PPI in rats was explored after oral administration. METHODS: PCM rats, namely mal-nourished (MN) rats, were induced from well-nourished (WN) rats by caloric restriction protocol...
March 28, 2018: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29587670/to-fast-or-not-to-fast-before-chemotherapy-that-is-the-question
#15
Riccardo Caccialanza, Emanuele Cereda, Francesco De Lorenzo, Gabriella Farina, Paolo Pedrazzoli
Fasting in disease prevention and treatment has recently become a popular topic, particularly in the context of oncology. Unfortunately, the growing attention paid by the media has created a background of speculations and ambiguous messages. The attitude towards the role of fasting in cancer patients should be very cautious, as the risk of malnutrition/sarcopenia and disinformation may be associated with this approach. Whether the results obtained by fasting in the cellular and animal models can be transferred to cancer patients is still to be ascertained...
March 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29577206/stress-response-to-physical-exercise-in-rats-with-alimentary-obesity
#16
N A Pal'chikova, O I Kuzminova, V G Selyatitskaya
Stress response to physical exercise was studied in rats with alimentary obesity with and without caloric diet restriction. Daily excretion of corticosterone, progesterone, and testosterone, weights of internal organs, and serum levels of glucose, free fatty acids, triglycerides, corticosterone, and testosterone were estimated. Stress response to moderate exercise in rats with alimentary obesity was associated with predominance of anabolic influence of testosterone over the catabolic effects of corticosterone, which promoted the increase in the weight of reproductive organs...
March 26, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29576535/metabolic-slowing-and-reduced-oxidative-damage-with-sustained-caloric-restriction-support-the-rate-of-living-and-oxidative-damage-theories-of-aging
#17
Leanne M Redman, Steven R Smith, Jeffrey H Burton, Corby K Martin, Dora Il'yasova, Eric Ravussin
Calorie restriction (CR) is a dietary intervention with potential benefits for healthspan improvement and lifespan extension. In 53 (34 CR and 19 control) non-obese adults, we tested the hypothesis that energy expenditure (EE) and its endocrine mediators are reduced with a CR diet over 2 years. Approximately 15% CR was achieved over 2 years, resulting in an average 8.7 kg weight loss, whereas controls gained 1.8 kg. In the CR group, EE measured over 24 hr or during sleep was approximately 80-120 kcal/day lower than expected on the basis of weight loss, indicating sustained metabolic adaptation over 2 years...
March 12, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29576121/anti-nociceptive-effects-of-caloric-restriction-on-neuropathic-pain-in-rats-involves-silent-information-regulator-1
#18
Y Liu, Y Ni, W Zhang, Y E Sun, M Jiang, W J Gu, Z L Ma, X P Gu
BACKGROUND: Caloric restriction (CR) increases both average and maximum lifespan, retards physiological signs of ageing, and delays the onset of several diseases and may mediate neuropathic pain. Neuropathic pain seriously affects the quality of life of patients. In this study, we investigated whether CR exerts anti-nociceptive effects on neuropathic pain, and probed its potential mechanisms. METHODS: Adult rats were divided into two dietary groups: an ad libitum (AL)-fed group and a CR group, which was provided with 60% of the food intake of AL rats for 6 weeks...
April 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29575469/the-effects-of-graded-caloric-restriction-xii-comparison-of-mouse-to-human-impact-on-cellular-senescence-in-the-colon
#19
Luigi Fontana, Sharon E Mitchell, Boshi Wang, Valeria Tosti, Thijmen van Vliet, Nicola Veronese, Beatrice Bertozzi, Dayna S Early, Parcival Maissan, John R Speakman, Marco Demaria
Calorie restriction (CR) is an effective strategy to delay the onset and progression of aging phenotypes in a variety of organisms. Several molecular players are involved in the anti-aging effects of CR, but mechanisms of regulation are poorly understood. Cellular senescence-a cellular state of irreversible growth arrest-is considered a basic mechanism of aging. Senescent cells accumulate with age and promote a number of age-related pathologies. Whether environmental conditions such as diet affect the accumulation of cellular senescence with age is still unclear...
March 25, 2018: Aging Cell
https://www.readbyqxmd.com/read/29556949/more-sugar-no-thank-you-the-elusive-nature-of-low-carbohydrate-diets
#20
REVIEW
Dario Giugliano, Maria Ida Maiorino, Giuseppe Bellastella, Katherine Esposito
In the past decades, dietary guidelines focused on reducing saturated fat as the primary strategy for cardiovascular disease prevention, neglecting the many other potential effects of diet on health, in particular the harmful effects of sugar. A greater intake of soft drinks (sugar-sweetened beverages), for example, is associated with a 44% increased prevalence of metabolic syndrome, a higher risk of obesity, and a 26% increased risk of developing diabetes mellitus. Carbohydrates comprise around 55% of the typical western diet, ranging from 200 to 350 g/day in relation to a person's overall caloric intake...
March 19, 2018: Endocrine
keyword
keyword
55315
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"