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https://www.readbyqxmd.com/read/27927951/effects-of-the-selective-%C3%AE-5-gabaar-antagonist-s44819-on-excitability-in-the-human-brain-a-tms-emg-and-tms-eeg-phase-i-study
#1
Ghazaleh Darmani, Carl M Zipser, Gabriele M Böhmer, Karine Deschet, Florian Müller-Dahlhaus, Paolo Belardinelli, Matthias Schwab, Ulf Ziemann
: Alpha-5 gamma-aminobutyric acid type A receptors (α5-GABAARs) are located extrasynaptically, regulate neuronal excitability through tonic inhibition, and are fundamentally important for processes such as plasticity and learning. For example, pharmacological blockade of α5-GABAAR in mice with ischemic stroke improved recovery of function by normalizing exaggerated perilesional α5-GABAAR-dependent tonic inhibition. S44819 is a novel competitive selective antagonist of the α5-GABAAR at the GABA-binding site...
December 7, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27912170/influence-of-attention-alternation-on-movement-related-cortical-potentials-in-healthy-individuals-and-stroke-patients
#2
Susan Aliakbaryhosseinabadi, Vladimir Kostic, Aleksandra Pavlovic, Sasa Radovanovic, Ernest Nlandu Kamavuako, Ning Jiang, Laura Petrini, Kim Dremstrup, Dario Farina, Natalie Mrachacz-Kersting
OBJECTIVE: In this study, we analyzed the influence of artificially imposed attention variations using the auditory oddball paradigm on the cortical activity associated to motor preparation/execution. METHODS: EEG signals from Cz and its surrounding channels were recorded during three sets of ankle dorsiflexion movements. Each set was interspersed with either a complex or a simple auditory oddball task for healthy participants and a complex auditory oddball task for stroke patients...
November 10, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27910806/epilepsia-partialis-continua-aetiology-semiology-and-prognosis-in-a-spanish-adult-cohort
#3
Helena Bejr-Kasem, Jacint Sala-Padró, Manuel Toledo, Estevo Santamarina, Silvana Sarria, Montserrat Gonzalez-Cuevas, María Sueiras-Gil, Manolo Quintana, Xavier Salas-Puig
To describe the semiological features in patients suffering with Epilepsia Partialis Continua (EPC), also referred as Kozhevnikov syndrome and their relationship with aetiology, duration, and prognosis, as well as recurrence during follow-up. We analysed consecutive EPC patients diagnosed and followed in our centre over a seven-and-a half year period. We collected demographic and clinical data, along with neuroimaging and EEG recordings. All patients were followed for more than six months. Patients were categorised with single body area or multiple body area involvement according to the body parts affected...
December 2, 2016: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/27882256/eeg-triggered-functional-electrical-stimulation-therapy-for-restoring-upper-limb-function-in-chronic-stroke-with-severe-hemiplegia
#4
Cesar Marquez-Chin, Aaron Marquis, Milos R Popovic
We report the therapeutic effects of integrating brain-computer interfacing technology and functional electrical stimulation therapy to restore upper limb reaching movements in a 64-year-old man with severe left hemiplegia following a hemorrhagic stroke he sustained six years prior to this study. He completed 40 90-minute sessions of functional electrical stimulation therapy using a custom-made neuroprosthesis that facilitated 5 different reaching movements. During each session, the participant attempted to reach with his paralyzed arm repeatedly...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27867700/mental-stress-assessment-using-simultaneous-measurement-of-eeg-and-fnirs
#5
Fares Al-Shargie, Masashi Kiguchi, Nasreen Badruddin, Sarat C Dass, Ahmad Fadzil Mohammad Hani, Tong Boon Tang
Previous studies reported mental stress as one of the major contributing factors leading to various diseases such as heart attack, depression and stroke. An accurate stress assessment method may thus be of importance to clinical intervention and disease prevention. We propose a joint independent component analysis (jICA) based approach to fuse simultaneous measurement of electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) on the prefrontal cortex (PFC) as a means of stress assessment...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27844464/the-safety-and-effectiveness-of-intravenous-lacosamide-for-refractory-status-epilepticus-in-the-critically-ill
#6
C R Newey, N M Le, C Ahrens, P Sahota, S Hantus
BACKGROUND: Status epilepticus (SE) often does not respond to initial treatment. A second-line agent with a less established safety and efficacy profile is then required. This study examined the safety of intravenous (IV) lacosamide (LCM) in a critically ill population and obtained an estimate of effectiveness in patients with refractory SE on continuous video EEG monitoring (cEEG). METHODS: Retrospective review of critically ill patients in SE on cEEG treated with IV LCM from June 2009 to April 2011...
November 14, 2016: Neurocritical Care
https://www.readbyqxmd.com/read/27818001/simultaneous-eeg-fnirs-reveals-how-age-and-feedback-affect-motor-imagery-signatures
#7
Catharina Zich, Stefan Debener, Ann-Kathrin Thoene, Ling-Chia Chen, Cornelia Kranczioch
Stroke frequently results in motor impairment. Motor imagery (MI), the mental practice of movements, has been suggested as a promising complement to other therapeutic approaches facilitating motor rehabilitation. Of particular potential is the combination of MI with neurofeedback (NF). However, MI NF protocols have been largely optimized only in younger healthy adults, although strokes occur more frequently in older adults. The present study examined the influence of age on the neural correlates of MI supported by electroencephalogram (EEG)-based NF and on the neural correlates of motor execution...
October 15, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27814760/clinical-predictors-of-seizure-recurrence-after-the-first-post-ischemic-stroke-seizure
#8
Hyeon Jin Kim, Kee Duk Park, Kyoung-Gyu Choi, Hyang Woon Lee
BACKGROUND: The number of patients suffering post-stroke seizure after ischemic stroke (PSSi) is quite considerable, especially because ischemic stroke is more prevalent than hemorrhage in the general population. This study aimed to determine the predicting factors for seizure recurrence in ischemic stroke survivors and develop a clinical scoring system for the prediction of risks for seizure recurrence after the first PSSi. METHODS: We reviewed 3792 ischemic stroke patients from the Ewha Stroke Registry...
November 5, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27809371/abnormal-neurodevelopmental-outcomes-are-very-likely-in-cases-of-bilateral-neonatal-arterial-ischaemic-stroke
#9
Ju Hyun Jin, Jeong Eun Shin, Soonmin Lee, Ho Sun Eun, Min Soo Park, Kook In Park, Ran Namgung
AIM: Neonatal arterial ischaemic stroke (AIS) is an important cause of severe neurological disability. This study aimed to analyse the clinical manifestations and outcomes of AIS patients. METHODS: We enrolled neonates with AIS admitted to Severance Children's Hospital and Gangnam Severance Hospital between 2008 and 2015. AIS was confirmed using magnetic resonance imaging (MRI). We retrospectively reviewed the clinical manifestations, MRI findings, electroencephalography (EEG) findings and neurodevelopmental outcomes...
November 3, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27808125/decoding-of-top-down-cognitive-processing-for-ssvep-controlled-bmi
#10
Byoung-Kyong Min, Sven Dähne, Min-Hee Ahn, Yung-Kyun Noh, Klaus-Robert Müller
We present a fast and accurate non-invasive brain-machine interface (BMI) based on demodulating steady-state visual evoked potentials (SSVEPs) in electroencephalography (EEG). Our study reports an SSVEP-BMI that, for the first time, decodes primarily based on top-down and not bottom-up visual information processing. The experimental setup presents a grid-shaped flickering line array that the participants observe while intentionally attending to a subset of flickering lines representing the shape of a letter...
November 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27754798/motor-cortex-plasticity-in-children-with-spastic-cerebral-palsy-a-systematic-review
#11
Natália de Almeida Carvalho Duarte, Luanda André Collange Grecco, Nelci Zanon, Manuela Galli, Felipe Fregni, Claudia Santos Oliveira
A review of the literature was performed to answer the following questions: Does motor cortex excitability correlate with motor function? Do motor cortex excitability and cortex activation change after a rehabilitation program that results in improvements in motor outcomes? Can the 10-20 electroencephalography (EEG) system be used to locate the primary motor cortex when employing transcranial direct current stimulation? Is there a bihemispheric imbalance in individuals with cerebral palsy similar to what is observed in stroke survivors? the authors found there is an adaptation in the geometry of motor areas and the cortical representation of movement is variable following a brain lesion...
October 18, 2016: Journal of Motor Behavior
https://www.readbyqxmd.com/read/27706094/3d-printed-dry-eeg-electrodes
#12
Sammy Krachunov, Alexander J Casson
Electroencephalography (EEG) is a procedure that records brain activity in a non-invasive manner. The cost and size of EEG devices has decreased in recent years, facilitating a growing interest in wearable EEG that can be used out-of-the-lab for a wide range of applications, from epilepsy diagnosis, to stroke rehabilitation, to Brain-Computer Interfaces (BCI). A major obstacle for these emerging applications is the wet electrodes, which are used as part of the EEG setup. These electrodes are attached to the human scalp using a conductive gel, which can be uncomfortable to the subject, causes skin irritation, and some gels have poor long-term stability...
October 2, 2016: Sensors
https://www.readbyqxmd.com/read/27696001/perioperative-stroke-after-carotid-endarterectomy-etiology-and-implications
#13
Nicolas K Khattar, Robert M Friedlander, Rabih A Chaer, Efthymios D Avgerinos, Eric S Kretz, Jeffrey R Balzer, Donald J Crammond, Miguel H Habeych, Parthasarathy D Thirumala
BACKGROUND: Carotid endarterectomy (CEA) is the procedure of choice for reducing the risk of stroke in both symptomatic and asymptomatic carotid artery stenoses. Stroke is associated with significant morbidity and mortality peri-operatively (2-3 %). Our primary aim is to evaluate the etiology of these strokes after CEA and their impact on morbidity by comparing the length of stay in the hospital. METHODS: A total of 584 patients with documented neurological status evaluations who underwent CEAs were included in the study...
September 30, 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27677025/a-closed-loop-bci-system-for-rehabilitation-of-the-hemiplegic-upper-limb-a-performance-study-of-the-systems-ability-to-detect-intention-of-movement
#14
Juliette Hurtier, Leh Van Dokkum, Sami Dalhoumi, Aodhan Coffey, Stéphane Perrey, Claire Jourdan, Gérard Dray, Tomas Ward, Jerôme Froger, Isabelle Laffont
OBJECTIVE: Rehabilitation of the upper-limb by means of a brain computer interface (BCI) is based on detecting an "intention to act" in the brain and transforming this intention into actual movement by using a motorized orthesis. The visual and proprioceptive feedback that results from the systems' generated movement following the subjects' captured intention, is thought to close the sensori-motor loop. Closing the loop is a key feature of BCI-systems that is thought to induce cerebral plasticity and thereby facilitating rehabilitation...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27672628/optimized-seizure-detection-algorithm-a-fast-approach-for-onset-of-epileptic-in-eeg-signals-using-gt-discriminant-analysis-and-k-nn-classifier
#15
Kh Rezaee, E Azizi, J Haddadnia
BACKGROUND: Epilepsy is a severe disorder of the central nervous system that predisposes the person to recurrent seizures. Fifty million people worldwide suffer from epilepsy; after Alzheimer's and stroke, it is the third widespread nervous disorder. OBJECTIVE: In this paper, an algorithm to detect the onset of epileptic seizures based on the analysis of brain electrical signals (EEG) has been proposed. 844 hours of EEG were recorded form 23 pediatric patients consecutively with 163 occurrences of seizures...
June 2016: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/27636359/a-comparison-of-independent-event-related-desynchronization-responses-in-motor-related-brain-areas-to-movement-execution-movement-imagery-and-movement-observation
#16
Jeng-Ren Duann, Jin-Chern Chiou
Electroencephalographic (EEG) event-related desynchronization (ERD) induced by movement imagery or by observing biological movements performed by someone else has recently been used extensively for brain-computer interface-based applications, such as applications used in stroke rehabilitation training and motor skill learning. However, the ERD responses induced by the movement imagery and observation might not be as reliable as the ERD responses induced by movement execution. Given that studies on the reliability of the EEG ERD responses induced by these activities are still lacking, here we conducted an EEG experiment with movement imagery, movement observation, and movement execution, performed multiple times each in a pseudorandomized order in the same experimental runs...
2016: PloS One
https://www.readbyqxmd.com/read/27635604/-predictors-of-epilepsy-in-children-after-ischemic-stroke
#17
O A L'vova, L V Shal'kevich, A N Dron', M Yu Lukashchuk, E A Orlova, V V Gusev, E V Suleimanova, A V Sulimov, A I Kudlach
AIM: To determine clinical/instrumental predictors of symptomatic epilepsy after ischemic stroke in children. MATERIAL AND METHODS: One hundred and thirty-six patients, aged 0-15 years, with the diagnosis of ischemic stroke (ICD-10 I63.0-I63.9) were examined. The duration of the study was 18 months - 12 years. Patients were stratified into post-stroke (n=22) and control (n=114) groups, the latter included patients without epilepsy regardless of the presence of convulsive seizures in the acute stage of stroke...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27631161/beyond-aphasia-altered-eeg-connectivity-in-broca-s-patients-during-working-memory-task
#18
Veronika Rutar Gorišek, Vlasta Zupanc Isoski, Aleš Belič, Christina Manouilidou, Blaž Koritnik, Jure Bon, Nuška Pečarič Meglič, Matej Vrabec, Janez Žibert, Grega Repovš, Janez Zidar
Broca's region and adjacent cortex presumably take part in working memory (WM) processes. Electrophysiologically, these processes are reflected in synchronized oscillations. We present the first study exploring the effects of a stroke causing Broca's aphasia on these processes and specifically on synchronized functional WM networks. We used high-density EEG and coherence analysis to map WM networks in ten Broca's patients and ten healthy controls during verbal WM task. Our results demonstrate that a stroke resulting in Broca's aphasia also alters two distinct WM networks...
September 12, 2016: Brain and Language
https://www.readbyqxmd.com/read/27625600/neurophysiologic-correlates-of-post-stroke-mood-and-emotional-control
#19
Deniz Doruk, Marcel Simis, Marta Imamura, André R Brunoni, Leon Morales-Quezada, Renato Anghinah, Felipe Fregni, Linamara R Battistella
OBJECTIVE: Emotional disturbance is a common complication of stroke significantly affecting functional recovery and quality of life. Identifying relevant neurophysiologic markers associated with post-stroke emotional disturbance may lead to a better understanding of this disabling condition, guiding the diagnosis, development of new interventions and the assessments of treatment response. METHODS: Thirty-five subjects with chronic stroke were enrolled in this study...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27590975/interfacing-brain-with-computer-to-improve-communication-and-rehabilitation-after-brain-damage
#20
A Riccio, F Pichiorri, F Schettini, J Toppi, M Risetti, R Formisano, M Molinari, L Astolfi, F Cincotti, D Mattia
Communication and control of the external environment can be provided via brain-computer interfaces (BCIs) to replace a lost function in persons with severe diseases and little or no chance of recovery of motor abilities (ie, amyotrophic lateral sclerosis, brainstem stroke). BCIs allow to intentionally modulate brain activity, to train specific brain functions, and to control prosthetic devices, and thus, this technology can also improve the outcome of rehabilitation programs in persons who have suffered from a central nervous system injury (ie, stroke leading to motor or cognitive impairment)...
2016: Progress in Brain Research
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