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peliosis hepatis

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https://www.readbyqxmd.com/read/28721347/peliosis-hepatis-complicating-pregnancy-a-rare-entity
#1
Muhammad Osama Butt, Nasir Hassan Luck, Syed Mujahid Hassan, Zaigham Abbas, Muhammed Mubarak
Peliosis hepatis (PH) is a rare, benign condition of the liver characterized by the presence of blood-filled lacunar spaces in the parenchyma. It usually has a chronic presentation and is a rare cause of portal hypertension reported in adult patients. Its etiology is diverse and ranges from infectious agents to tumors to toxic substances and anabolic steroids; however, the cause remains unclear in 25-50% of patients. Similarly, the symptomatology and imaging findings are diverse. Biopsy is the definitive test to diagnose the condition...
June 2017: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/28430541/a-comprehensive-approach-to-hepatic-vascular-disease
#2
Khaled M Elsayes, Akram M Shaaban, Sarah M Rothan, Sanaz Javadi, Beatrice L Madrazo, Rosa P Castillo, Victor J Casillas, Christine O Menias
The liver has a complex vascular supply, which involves the inflow of oxygenated blood through the hepatic artery (systemic circulation) and deoxygenated blood through the portal vein (portal circulation), as well as the outflow of deoxygenated blood through the hepatic veins to the inferior vena cava. A spectrum of vascular variants can involve the liver. Some of these variants may result in areas of enhancement that can mimic more serious pathologic conditions. In this article, the authors discuss a spectrum of variants and pathologic conditions that may involve the liver vasculature...
May 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28379599/hepatotoxicity-associated-with-illicit-use-of-anabolic-androgenic-steroids-in-doping
#3
R Solimini, M C Rotolo, L Mastrobattista, C Mortali, A Minutillo, S Pichini, R Pacifici, I Palmi
Anabolic Androgenic Steroids (AAS) abuse and misuse is nowadays a harmful habit involving both professional or recreational athletes, as well as general population. AAS are also frequently present in over-the-counter dietary supplements without being declared in the list of ingredients, leaving consumers unaware of the risks of adverse effects. Indeed, health risks of AAS consumption in pharmaceutical preparations or dietary complements seem still underestimated and under-reported. The variety of complications due to AAS misuse involves cardiovascular, central nervous, musculoskeletal and genitourinary systems of both males and females; psychiatric and behavioral effects, damages to metabolic system, skin and mainly liver...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28353584/peliosis-hepatis-2-case-reports-of-a-rare-liver-disorder-and-its-differential-diagnosis
#4
Yi-Ning Dai, Ze-Ze Ren, Wen-Yuan Song, Hai-Jun Huang, Dan-Hong Yang, Ming-Shan Wang, Yi-Cheng Huang, Mei-Juan Chen, Jia-Jie Zhang, Yong-Xi Tong, Hong-Ying Pan
RATIONALE: Peliosis hepatis (PH) is a rare tumor-like liver lesion composed of multiple blood-filled cavities within the liver parenchyma. It is hard to differentiate PH from other liver lesions by imaging, such as carcinoma, metastases, or abscess. PATIENT CONCERNS: Here, we reported 2 cases that presented with liver lesions under ultrasound and computed tomography (CT) scanning, without any history of liver diseases or drug usage traced back. DIAGNOSES: Liver biopsy and laparoscopy were processed, and the lesions were eventually diagnosed as PH by histopathology, which microscopically presented with multiple sinusoidal dilatations with blood-filled cystic spaces...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28180205/contrast-enhanced-ultrasound-of-a-rare-case-of-peliosis-hepatis
#5
Alexander Loizides, Bernhard Glodny, Heinz Zoller, Bettina Gudrun Zelger, Daniel Junker, Benjamin Henninger, Daniel Putzer, Hannes Gruber
Peliosis hepatis is a rare benign disorder of the liver, histologically characterized by blood-filled cystic cavities of various sizes and irregular shapes, communicating with the hepatic sinusoids. Only a few cases of peliosis hepatis have been described using contrast enhanced ultrasound showing admittedly various dynamic enhancement patterns. We present a case of peliosis hepatis with a typical target-sign enhancement depicted by means of contrast enhanced ultrasound.
January 31, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/27783341/peliosis-hepatis-mimicking-malignant-hypervascular-tumors
#6
Tomoyuki Iwata, Kensuke Adachi, Manabu Takahashi
BACKGROUND: Peliosis hepatis is an uncommon vascular condition characterized by multiple, randomly distributed, blood-filled, and cyst-like cavities throughout the liver. The unique clinical nature consisting of an asymptomatic, benign, and incidental finding sometimes conceals itself even until autopsy. However, the exact pathomechanism remains as yet unproven. METHOD: We encountered the patient with multiple hypervascular masses in the whole liver and investigated the clinicopathological features underlying this condition...
October 25, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27599419/danazol-induced-peliosis-hepatis-accompanied-by-disseminated-intravascular-coagulation-in-a-patient-with-myelodysplastic-syndrome-transformed-from-aplastic-anemia
#7
REVIEW
Yasuhiro Tsukamoto, Junichi Kiyasu, Hayato Utsunomiya, Yasuhiro Nakashima, Ilseung Choi, Youko Suehiro, Yoshifusa Aratake, Yasunobu Abe
Peliosis hepatis (PH) is a condition involving benign tumors pathologically characterized by multiple blood-filled cavities, mostly affecting the liver and spleen. Androgenic-steroids are widely used in patients with bone marrow failure syndromes (e.g.: aplastic anemia) and these patients are at increased risk of developing PH. Although patients with PH are generally asymptomatic, PH can progress to liver failure and even fatal spontaneous intraabdominal hemorrhage. Therefore, early diagnosis is critical in order to prevent life-threatening complications of PH...
August 2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/27375211/the-centenary-of-the-discovery-of-trench-fever-an-emerging-infectious-disease-of-world-war-1
#8
REVIEW
Gregory M Anstead
In 1915, a British medical officer on the Western Front reported on a soldier with relapsing fever, headache, dizziness, lumbago, and shin pain. Within months, additional cases were described, mostly in frontline troops, and the new disease was called trench fever. More than 1 million troops were infected with trench fever during World War 1, with each affected soldier unfit for duty for more than 60 days. Diagnosis was challenging, because there were no pathognomonic signs and symptoms and the causative organism could not be cultured...
August 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27372877/anabolic-androgenic-steroid-induced-hepatotoxicity
#9
Peter Bond, William Llewellyn, Peter Van Mol
Anabolic androgenic steroids (AAS) have been abused for decades by both professional and amateur athletes in order to improve physical performance or muscle mass. AAS abuse can cause adverse effects, among which are hepatotoxic effects. These effects include cholestatic icterus and possibly peliosis hepatis and hepatocellular carcinoma or adenoma. In particular, 17α-alkylated AAS appear to be hepatotoxic, whereas nonalkylated AAS appear not to be. The 17α-alkyl substitution retards hepatic metabolism of the AAS rendering it orally bioavailable...
August 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27074964/resolution-of-spontaneous-hemoabdomen-secondary-to-peliosis-hepatis-following-surgery-and-azithromycin-treatment-in-a-bartonella-species-infected-dog
#10
Steven T Berkowitz, Kristi M Gannon, Carol A Carberry, Yonaira Cortes
OBJECTIVE: To describe a case of hemoperitonium in a dog with Bartonellosis and peliosis hepatis (PH) lesions that resolved following antimicrobial therapy. CASE SUMMARY: A 3-year-11-month-old 22.5 kg female spayed mixed breed dog presented for progressive lethargy and vomiting. An abdominal ultrasonographic examination revealed moderate ascites, which when sampled was nonclotting hemorrhagic fluid. An exploratory laparotomy revealed a large volume of nonclotted blood in the dog's abdomen and blood-filled vesicular lesions dispersed diffusely along multiple lobes of the liver...
November 2016: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/27073565/oxaliplatin-induced-sinusoidal-obstruction-syndrome-mimicking-metastatic-colon-cancer-in-the-liver
#11
Jung-Hye Choi, Young-Woong Won, Hyun Sung Kim, Young-Ha Oh, Sanghyeok Lim, Han-Joon Kim
Oxaliplatin is an effective chemotherapeutic agent for the treatment of colorectal cancer; however, it may cause liver injury, particularly sinusoidal obstruction syndrome (SOS). Although SOS does not usually present with focal lesions on radiological images, the present study describes the case of a 22-year-old woman with oxaliplatin-induced SOS mimicking metastatic colon cancer in the liver. An abdominal computed tomography revealed a novel 1 cm, low-density lesion in segment 1 of the liver following the administration of the fourth round of oxaliplatin-based adjuvant chemotherapy for stage III colon cancer...
April 2016: Oncology Letters
https://www.readbyqxmd.com/read/26770930/focal-type-of-peliosis-hepatis
#12
Gil-Sun Hong, Kyoung Won Kim, Jihyun An, Ju Hyun Shim, Jihun Kim, Eun Sil Yu
No abstract text is available yet for this article.
December 2015: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/26770928/peliosis-hepatis-presenting-with-massive-hepatomegaly-in-a-patient-with-idiopathic-thrombocytopenic-purpura
#13
Sun Bean Kim, Do Kyung Kim, Sun Jeong Byun, Ji Hye Park, Jin Young Choi, Young Nyun Park, Do Young Kim
Peliosis hepatis is a rare condition that can cause hepatic hemorrhage, rupture, and ultimately liver failure. Several authors have reported that peliosis hepatis develops in association with chronic wasting disease or prolonged use of anabolic steroids or oral contraceptives. In this report we describe a case in which discontinuation of steroid therapy improved the condition of a patient with peliosis hepatis. Our patient was a 64-year-old woman with a history of long-term steroid treatment for idiopathic thrombocytopenic purpura ...
December 2015: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/26675327/peliosis-hepatis-personal-experience-and-literature-review
#14
REVIEW
Daniele Crocetti, Andrea Palmieri, Giuseppe Pedullà, Vittorio Pasta, Valerio D'Orazi, Gian Luca Grazi
Peliosis hepatis (PH) is a disease characterized by multiple and small, blood-filled cysts within the parenchymatous organs. PH is a very rare disease, more common in adults, and when it affects the liver, it comes to the surgeon's attention only in an extremely urgent situation after the lesion's rupture with the resulting hemoperitoneum. This report describes the case of a 29-year-old woman affected by recurring abdominal pain. Computed tomography scans showed a hepatic lesion formed by multiple hypodense areas, which showed an early acquisition of the contrast during the arterial phase...
December 14, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26362063/peliosis-hepatis-disseminated-rapidly-throughout-the-liver-in-a-patient-with-prostate-cancer-a-case-report
#15
Hisashi Hidaka, Makoto Ohbu, Takahide Nakazawa, Takaaki Matsumoto, Akitaka Shibuya, Wasaburo Koizumi
INTRODUCTION: In the World Health Organization histological classification of the liver tumor, peliosis hepatis is defined as a tumor-like lesion. The entity is characterized by the appearance of multiple cyst-like, blood-filled spaces within the liver parenchyma. CASE PRESENTATION: A 77-year-old Japanese man with prostate cancer was referred to our department because he was diagnosed as having two hepatic tumors. The tumors were confirmed to be peliosis hepatis by repeated needle biopsies and because of their atypical images by enhanced computed tomography and enhanced magnetic resonance imaging...
September 12, 2015: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/26316825/spontaneous-rupture-of-multifocal-hepatocellular-carcinoma-case-report
#16
Özkan Özen, Alptekin Tosun, Çiğdem Akgül
Hemoperitoneum due to nontraumatic liver rupture is rare. The most common cause of nontraumatic rupture of the liver is hepatocellular carcinoma (HCC). The other causes of nontraumatic liver ruptures are peliosis hepatis, polyarteritis nodosa, systemic lupus erythematosus, preeclampsia, metastatic carcinoma, and other primary liver tumors. In this report, we present the computed tomography findings of spontaneous liver rupture in a 52-year-old male patient due to multifocal HCC, with the diagnosis proven by surgical specimen...
2015: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/26252245/spontaneous-hepatic-haemorrhage-a-review-of-pathogenesis-aetiology-and-treatment
#17
REVIEW
Sanket Srinivasa, Wai G Lee, Ali Aldameh, Jonathan B Koea
BACKGROUND: A spontaneous hepatic haemorrhage (SHH) is a rare condition that presents acutely to both hepatobiliary and general surgeons. Management of the condition is challenging because of the emergent presentation requiring immediate intervention, the presence of underlying chronic liver disease and the multiple potential underlying aetiological conditions. METHODS: A literature search on a spontaneous hepatic haemorrhage was instituted on Medline (1966-2014), Cochrane Register of Controlled Trials, EMBASE (1947-2014), PubMed, Web of Science and Google Scholar...
October 2015: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/26219941/generalised-peliosis-hepatis-mimicking-metastases-after-long-term-use-of-oral-contraceptives
#18
A M M Kootte, A M Siegel, M Koorenhof
Peliosis hepatis (PH) is a rare vascular condition of the liver characterised by the presence of cystic blood-filled cavities distributed randomly throughout the liver parenchyma. PH should be considered in the differential diagnosis of women with a long history of use of oral contraceptives with suspected hypervascular lesions diagnosed by imaging, but with an unknown primary tumour. Because of the extensive use of oral contraceptives in the general female population worldwide, PH should be added to the differential diagnosis of suspected hypervascular liver lesions...
January 2015: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/26019044/spontaneous-hepatic-rupture-during-pregnancy-in-a-patient-with-peliosis-hepatis
#19
Stefania Cimbanassi, Paolo Aseni, Anna Mariani, Fabrizio Sammartano, Edgardo Bonacina, Osvaldo Chiara
Spontaneous hepatic rupture (SHR) during pregnancy is a rare but well known complication and it usually occurs alongside eclampsia or HELLP syndrome. SHR in uncomplicated pregnancy is extremely rare and can be associated to different undiagnosed pathological conditions. We report the case of a nulliparous woman, 27 weeks pregnant, with a peliosis hepatis, previously unknown, who was admitted to our unit due to SHR and massive hemoperitoneum. The conception was obtained by embryo transfer after multiple attempts of hormone-supported cycles using estrogens and progesterone...
July 2015: Annals of Hepatology
https://www.readbyqxmd.com/read/25690669/heterozygous-p53-knockout-mouse-model-for-dehydropyrrolizidine-alkaloid-induced-carcinogenesis
#20
Ammon W Brown, Bryan L Stegelmeier, Steven M Colegate, Kip E Panter, Edward L Knoppel, Jeffery O Hall
Dehydropyrrolizidine alkaloids (DHPA) are a large, structurally diverse group of plant-derived protoxins that are potentially carcinogenic. With worldwide significance, these alkaloids can contaminate or be naturally present in the human food supply. To develop a small animal model that may be used to compare the carcinogenic potential of the various DHPAs, male heterozygous p53 knockout mice were administered a short-term treatment of riddelliine 5, 15 or 45 mg kg(-1) bodyweight day(-1) by oral gavage for 14 days, or dosed a long-term treatment of riddelliine 1 mg kg(-1) bodyweight day(-1) in pelleted feed for 12 months...
December 2015: Journal of Applied Toxicology: JAT
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