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https://www.readbyqxmd.com/read/28640987/independent-effects-of-apolipoprotein-e-and-cerebrovascular-burden-on-later-life-depression-the-wisconsin-longitudinal-study
#1
Rosanna G Scott, Daniel L Paulson
OBJECTIVE: Studies evaluating the effect of apolipoprotein E (APOE) on vascular depression are sparse, employ heterogeneous methods, and yield inconsistent results. One possibility is that APOE is a moderator of another predictor such as cerebrovascular burden. This longitudinal study examines the relationships between APOE, cerebrovascular burden, and depressive symptomatology in a large cohort sample from midlife to later life. METHODS: Data include 3,203 participants across 18 years (1993-2011) from the Wisconsin Longitudinal Study (baseline mean age = 53 years)...
June 20, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28632874/screening-for-obesity-in-children-and-adolescents-us-preventive-services-task-force-recommendation-statement
#2
David C Grossman, Kirsten Bibbins-Domingo, Susan J Curry, Michael J Barry, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, Maureen G Phipps, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Based on year 2000 Centers for Disease Control and Prevention growth charts, approximately 17% of children and adolescents aged 2 to 19 years in the United States have obesity, and almost 32% of children and adolescents are overweight or have obesity. Obesity in children and adolescents is associated with morbidity such as mental health and psychological issues, asthma, obstructive sleep apnea, orthopedic problems, and adverse cardiovascular and metabolic outcomes (eg, high blood pressure, abnormal lipid levels, and insulin resistance)...
June 20, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28631075/measurement-and-evaluation-of-fetal-fat-layer-in-the-prediction-of-fetal-macrosomia-in-pregnancies-complicated-by-gestational-diabetes
#3
Mohamed Elessawy, Christina Harders, Helmut Kleinwechter, Norbert Demandt, Ghada Abu Sheasha, Nicolai Maass, Ulrich Pecks, Christel Eckmann-Scholz
OBJECTIVES: To explore the predictive power of measuring the abdominal fetal fat layer (FFL) as a soft tissue marker at 31, 34, and 37 weeks' gestation to improve the detection of fetal macrosomia in pregnant women with GDM, in addition to the biometric values with close monitoring of maternal blood sugar level and BMI changes. METHODS: We conducted a prospective observational study at the Department of Obstetrics, University Hospitals, Campus Kiel, Germany, in collaboration with diabetic clinic staff...
June 19, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28626866/activation-of-catalase-by-pioglitazone-multiple-spectroscopic-methods-combined-with-molecular-docking-studies
#4
Reza Yekta, Gholamreza Dehghan, Samaneh Rashtbari, Nader Sheibani, Ali Akbar Moosavi-Movahedi
Pioglitazone is an important prescription antidiabetic drug with positive roles in controlling high blood sugar in patients with type 2 diabetes. In the present study, we investigated the effects of pioglitazone on the structure and function of bovine liver catalase (BLC) using different spectroscopic and theoretical methods. UV-Vis absorption, fluorescence spectroscopy, synchronous fluorescence, and circular dichroism studies revealed conformational changes in the BLC structure and heme group in the presence of different concentrations of pioglitazone...
June 19, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28626746/frequency-of-cutaneous-fungal-infections-and-azole-resistance-of-the-isolates-in-patients-with-diabetes-mellitus
#5
Omid Raiesi, Mansour Siavash, Faezeh Mohammadi, Javaher Chabavizadeh, Behzad Mahaki, Mehrnoush Maherolnaghsh, Parvin Dehghan
BACKGROUND: Diabetic patients are more susceptible to cutaneous fungal infections. The higher blood sugar levels cause increasing the cutaneous fungal infections in these patients. The main objective of this study was to find the frequency of fungal infections among cutaneous lesions of diabetic patients and to investigate azole antifungal agent susceptibility of the isolates. MATERIALS AND METHODS: In this study, type 1diabetes (n = 78) and type 2 diabetes (n = 44) comprised 47 cases (38...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28622482/antidiabetic-properties-of-an-apple-kale-extract-in-vitro-in-situ-and-in-mice-fed-a-western-type-diet
#6
Anke Schloesser, Tuba Esatbeyoglu, Gerhard Schultheiß, Henning Vollert, Kai Lüersen, Alexandra Fischer, Gerald Rimbach
Type 2 diabetes mellitus (T2DM) is a common and increasingly prevalent metabolic disorder, and effective preventive strategies against this disease are needed. The aim of the present study was to evaluate the potential antidiabetic properties of a dietary apple/kale extract (AKE), which was rich in phlorizin and flavonoids, in laboratory mice. Mice were fed a control diet, a Western-type high-sugar, high-fat diet (WTD), or a WTD plus AKE for 10 weeks. Body weight, food and energy intake, body composition, and blood glucose level were recorded in addition to the postprandial rise in blood glucose concentration after a single administration of glucose (oral glucose tolerance test, OGTT)...
June 16, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28618839/sphingosine-kinase-and-sphingosine-1-phosphate-in-liver-pathobiology
#7
Timothy Rohrbach, Michael Maceyka, Sarah Spiegel
Over 20 years ago, sphingosine-1-phosphate (S1P) was discovered to be a bioactive signaling molecule. Subsequent studies later identified two related kinases, sphingosine kinase 1 and 2, which are responsible for the phosphorylation of sphingosine to S1P. Many stimuli increase sphingosine kinase activity and S1P production and secretion. Outside the cell, S1P can bind to and activate five S1P-specific G protein-coupled receptors (S1PR1-5) to regulate many important cellular and physiological processes in an autocrine or paracrine manner...
June 15, 2017: Critical Reviews in Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28617536/effects-of-mulberry-leaf-polysaccharide-on-oxidative-stress-in-pancreatic-%C3%AE-cells-of-type-2-diabetic-rats
#8
C-G Liu, Y-P Ma, X-J Zhang
OBJECTIVE: To explore and discuss the effects and mechanisms of mulberry leaf polysaccharide (MLP) on oxidative stress in pancreatic β-cells of type 2 diabetic rats. MATERIALS AND METHODS: The model of diabetic rats was established by inducing the Sprague-Dawley (SD) rats with high-sugar and high-fat diet for 6 weeks and then giving them streptozotocin (STZ) by single intraperitoneal injection. The mulberry leaf polysaccharide was administered via gavage daily for 8 weeks, and the tissue morphology was observed through electron microscopy...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28616051/omega-3-supplementation-effects-on-polycystic-ovary-syndrome-symptoms-and-metabolic-syndrome
#9
Behnaz Khani, Farahnaz Mardanian, Sajadeh Jafari Fesharaki
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder with unknown etiology and with different complications. The aim of this study was to evaluate the effect of omega-3 supplementation on PCOS symptoms and metabolic syndrome. MATERIALS AND METHODS: This double-blind clinical trial was performed in 2015 in Alzahra and Shahid Beheshti Hospitals, Isfahan, Iran, on 88 patients with PCOS. Intervention group took omega-3 supplements with dose of 2 g/day for 6 months (two capsules), but control group received two olive oil capsules...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28615764/evaluation-of-antioxidant-status-high-sensitivity-c-reactive-protein-and-insulin-resistance-in-male-chronic-opiate-users-without-comorbidities
#10
Purvi Purohit, Naresh Nebhinani, Praveen Sharma
BACKGROUND: There is a paucity of data on frequency of metabolic syndrome (MS), insulin resistance (IR), and oxidative stress in Indian opiate users without comorbidities. OBJECTIVES: To determine the influence of opiate use on frequency of MS, homeostasis model assessment for IR (HOMA-IR), high-sensitivity C-reactive protein (hs-CRP), and oxidative stress in opiate-dependent male patients without comorbidities. METHODS: Participants (n = 120) were grouped as controls (Group I), pure opiate dependents (Group II), opiate + tobacco dependents (Group III), and tobacco dependents (Group IV) with a minimum of 1-year dependence participated in the study...
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28612831/abdominal-obesity-and-type-2-diabetes-in-asian-indians-dietary-strategies-including-edible-oils-cooking-practices-and-sugar-intake
#11
REVIEW
S Gulati, A Misra
Obesity and type 2 diabetes are increasing in rural and urban regions of South Asia including India. Pattern of fat deposition in abdomen, ectopic fat deposition (liver, pancreas) and also low lean mass are contributory to early-onset insulin resistance, dysmetabolic state and diabetes in Asian Indians. These metabolic perturbations are further exacerbated by changing lifestyle, diet urbanization, and mechanization. Important dietary imbalances include increasing use of oils containing high amount of trans fatty acids and saturated fats (partially hydrogenated vegetable oil, palmolein oil) use of deep frying method and reheating of oils for cooking, high intake of saturated fats, sugar and refined carbohydrates, low intake of protein, fiber and increasing intake of processed foods...
June 14, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28611323/evaluation-of-gingival-blood-as-a-minimally-invasive-screening-tool-for-diabetes-mellitus-among-40-59-year-old-adults-in-dental-clinics-a-cross-sectional-study
#12
Indumathi K Partheeban, Preetha Chaly, Indra Priyadarshni, Mohammed Junaid, J E Nijesh, S Vaishnavi
OBJECTIVE: To evaluate a quick, safe, and minimally invasive method to screen for diabetes using gingival blood with the help of self-monitoring glucometer during periodontal examination. MATERIALS AND METHODS: A hospital-based, cross-sectional comparative study was conducted among 40-59-year-old diabetic and nondiabetic population who had come for their master health examination to a private tertiary care hospital (Global Hospital and Health City) in Chennai. Among them, those who fulfilled the inclusion criteria were selected for the study...
March 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28610738/blood-pressure-and-blood-sugar-assessment-by-recent-dental-school-graduates
#13
Michael N Hatton, Heather Orom, Patrick L Anders
OBJECTIVE: Recent dental school graduates' willingness to assess blood pressure and blood sugar in practice is positively influenced by having a workplace policy fostering these assessments. Negative influences toward these assessments include practice culture issues and time management concerns. The aim of this study was to determine whether 2010-2014 graduates of the School of Dental Medicine at Buffalo, NY (UB-SDM) continue to assess blood pressure and capillary blood sugar after graduation...
July 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28607565/the-prevalence-of-hypertension-and-its-relationship-with-demographic-factors-biochemical-and-anthropometric-indicators-a-population-based-study
#14
Mohammad Khajedaluee, Tahereh Hassannia, Abdolrahim Rezaee, Maryam Ziadi, Maliheh Dadgarmoghaddam
BACKGROUND: Hypertension (HTN) is an important public health challenge worldwide. The prevalence of HTN varies across countries. It is necessary to obtain valid information about the prevalence of chronic condition like HTN and its predictors in different societies. Hence, this study was conducted to assess the prevalence of HTN and associated factors in Mashhad, Iran, 2015. METHODS: This cross-sectional study was performed on 2974 adults residing in Mashhad in 2015...
November 2016: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/28607101/positive-and-negative-control-pathways-by-blood-components-for-intermedilysin-production-in-streptococcus-intermedius
#15
Toshifumi Tomoyasu, Takahiro Yamasaki, Shinya Chiba, Shingo Kusaka, Atsushi Tabata, Robert A Whiley, Hideaki Nagamune
Streptococcus intermedius is an opportunistic bacterial pathogen secreting a human-specific cytolysin called intermedilysin (ILY) as a major pathogenic factor. This bacterium can degrade glycans into monosaccharides using two glycosidases, multisubstrate glycosidase A (MsgA) and neuraminidase (NanA). Here, we detected a strong hemolytic activity mediated by ILY when Sintermedius PC574 was cultured in fetal bovine serum (FBS) as compared to the standard culture medium. FBS-cultured cells also showed higher MsgA and NanA activity although overproduction of ILY in FBS was undetectable in mutants nanA-null and msgA-null...
June 12, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28606937/effects-of-starvation-on-the-carbohydrate-metabolism-in-harmonia-axyridis-pallas
#16
Zuo-Kun Shi, Su Wang, Shi-Gui Wang, Lu Zhang, Yan-Xia Xu, Xiao-Jun Guo, Fan Zhang, Bin Tang
Trehalose plays an important role in energy storage, metabolism, and protection from extreme environmental conditions in insects. Trehalose is the main 'blood' sugar in insects, and it can be rapidly used as an energy source in times of need. To elucidate the mechanisms of the starvation response, we observed the effects of starvation on trehalose and glycogen, trehalase activity, and the relative gene expression of genes in the trehalose and glycogen metabolic pathways in the invasive beetle Harmonia axyridis Our results show that trehalose levels and the activities of two types of trehalases decreased significantly in the first 8 h of starvation, while the relative expression of HaTreh1-1 increased...
June 12, 2017: Biology Open
https://www.readbyqxmd.com/read/28599245/anti-inflammatory-and-ameliorative-effects-of-gallic-acid-on-fluoxetine-induced-oxidative-stress-and-liver-damage-in-rats
#17
Omid Karimi-Khouzani, Esfandiar Heidarian, Sayed Asadollah Amini
BACKGROUND: Fluoxetine-induced liver damage is a cause of chronic liver disease. In the present study the hepatoprotective effects of gallic acid against fluoxetine-induced liver damage were examined. METHODS: Forty-eight male rats were divided into six groups as follow: group 1, the control group; group 2, rats receiving fluoxetine (24mg/kg bw daily, po) without treatment; group 3, rats receiving 24mg/kg bw fluoxetine, treated with 50mg/kg bw silymarin and groups 4, 5, and 6 in which gallic acid (50, 100, and 200mg/kg bw, po, respectively) was prescribed after the consumption of fluoxetine...
March 23, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28598724/prevalence-awareness-and-factors-associated-with-hypertension-in-north-west-tanzania
#18
Neema R Mosha, Michael Mahande, Adinan Juma, Innocent Mboya, Rob Peck, Mark Urassa, Denna Michael, Jim Todd
BACKGROUND: Hypertension is a public health problem, and yet few people are aware of it and even fewer access effective treatment. With the ongoing demographic transition in many parts of Sub-Saharan Africa, people are changing from rural, manual work to urban lifestyles, hence the risk of hypertension increases. OBJECTIVE: This study aimed at determining the prevalence, awareness and risk factors associated with hypertension in North West Tanzania. DESIGN: A community-based cross-sectional study was conducted among adults in Magu District in 2013...
2017: Global Health Action
https://www.readbyqxmd.com/read/28598260/comparison-of-the-acceptance-of-telemonitoring-for-glucose-management-between-south-korea-and-china
#19
Mi Jung Rho, Hun-Sung Kim, Chenglin Sun, Guixia Wang, Kun-Ho Yoon, In Young Choi
BACKGROUND: Telemonitoring is used for glucose management and support in many countries. A better understanding of the differences in telemonitoring acceptance based on regional characteristics is needed. Therefore, we compared the acceptance of telemonitoring for glucose management among patients in South Korea and China. MATERIALS AND METHODS: This study used data from Korean (n = 81) and Chinese (n = 92) subjects with type 2 diabetes. We used two independent sample t-tests to compare patients' perceptions of telemonitoring and multiple regression analysis to determine the factors that affected their behavioral intentions to use telemonitoring...
June 9, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28598046/correlation-and-comparison-of-epicardial-adipose-tissue-with-sagittal-abdominal-diameter-and-other-anthropometric-and-biochemical-variables-of-metabolic-syndrome
#20
Meenaxi Sharda, Harish Nigam, S R Meena, Anil Soni, Anuraj Singh, Nitasha Sharma
OBJECTIVE: 1) To determine relation of epicardial adipose tissue (EAT) thickness with sagittal abdominal diameter (SAD) and other anthropometric measurements in metabolic syndrome (MetS). 2) To determine relation of epicardial adipose tissue with biochemical variables of metabolic syndrome. METHODS: Cases were recruited from the patients attending OPD in New Medical College Hospital, Govt. Medical College, Kota, Rajasthan, India between March 2015 to February 2016...
May 2017: Journal of the Association of Physicians of India
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