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https://www.readbyqxmd.com/read/29452623/currently-available-radiopharmaceuticals-for-imaging-infection-and-the-holy-grail
#1
REVIEW
Ebru Salmanoglu, Sung Kim, Mathew L Thakur
Infection is ubiquitous. However, its management is challenging for both the patients and the health-care providers. Scintigraphic imaging of infection dates back nearly half a century. The advances in our understanding of the pathophysiology of disease at cellular and molecular levels have paved the way to the development of a large number of radiopharmaceuticals for scintigraphic imaging of infection. These include radiolabeling of blood elements such as serum proteins, white blood cells (WBCs), and cytokines, to name a few...
March 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29450662/preconception-counseling-for-adolescents-and-young-adults-with-diabetes-a-literature-review-of-the-past-10-years
#2
REVIEW
Frances Peterson-Burch, Hiba Abujaradeh, Nicole Charache, Andrea Fischl, Denise Charron-Prochownik
PURPOSE OF REVIEW: Women with diabetes who have unplanned pregnancies and uncontrolled blood sugars are at a higher risk for maternal and fetal morbidities and mortalities. Preconception counseling (PC) has been shown to decrease the risks and improve health outcomes. From 2009 to 2017, the American Diabetes Association has recommended that preconception counseling be given at each clinic visit for all women with diabetes of childbearing age starting at puberty (prior to sexual debut)...
February 15, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29448285/-risk-factors-and-therapeutic-goals-for-primary-and-secondary-cardiovascular-prevention-significance-for-the-glaucoma-patient
#3
Claudia Hacke, Carl Erb, Burkhard Weisser
Hypertension, diabetes mellitus and dyslipidaemia are among the most important cardiovascular risk factors. In addition, there is an association with the development and progression of glaucoma. During the last years, there has been an intense discussion concerning optimal treatment goals for these risk factors. Recently, the American Heart Association has defined a blood pressure greater than 130/80 mmHg as hypertension and the European guidelines will follow this definition. These lower blood pressure limits increase the risk for a too strict blood pressure treatment with night values, which might be too low for glaucoma patients...
February 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29447929/a-complex-systems-approach-to-cancer-prevention
#4
P W Jupp
Cancer incidence continues to be a major health problem possibly because cancer is a complex system comprising many agents that interact in a non-linear manner resulting in many possible outcomes. The degree of complexity of a cancer system could be vast involving multiple endogenous and exogenous agents interacting with the over 10 trillion cells comprising the body. It is hypothesized that the practical management of this complexity may be a key to cancer prevention and possibly treatment. But the management and resolution of such an immensely complex system is difficult and may require a multidisciplinary approach including physics, biology, biochemistry and medical science...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29445344/invertebrate-trehalose-6-phosphate-synthase-gene-genetic-architecture-biochemistry-physiological-function-and-potential-applications
#5
REVIEW
Bin Tang, Su Wang, Shi-Gui Wang, Hui-Juan Wang, Jia-Yong Zhang, Shuai-Ying Cui
The non-reducing disaccharide trehalose is widely distributed among various organisms. It plays a crucial role as an instant source of energy, being the major blood sugar in insects. In addition, it helps countering abiotic stresses. Trehalose synthesis in insects and other invertebrates is thought to occur via the trehalose-6-phosphate synthase (TPS) and trehalose-6-phosphate phosphatase (TPP) pathways. In many insects, the TPP gene has not been identified, whereas multiple TPS genes that encode proteins harboring TPS/OtsA and TPP/OtsB conserved domains have been found and cloned in the same species...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29445091/thermal-stabilization-of-the-deglycating-enzyme-amadoriase-i-by-rational-design
#6
Federica Rigoldi, Stefano Donini, Francesca Giacomina, Federico Sorana, Alberto Redaelli, Tiziano Bandiera, Emilio Parisini, Alfonso Gautieri
Amadoriases are a class of FAD-dependent enzymes that are found in fungi, yeast and bacteria and that are able to hydrolyze glycated amino acids, cleaving the sugar moiety from the amino acidic portion. So far, engineered Amadoriases have mostly found practical application in the measurement of the concentration of glycated albumin in blood samples. However, these engineered forms of Amadoriases show relatively low absolute activity and stability levels, which affect their conditions of use. Therefore, enzyme stabilization is desirable prior to function-altering molecular engineering...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444663/gender-related-differences-in-cardiometabolic-risk-factors-and-lifestyle-behaviors-in-treatment-seeking-adolescents-with-severe-obesity
#7
Lisa Ha Barstad, Pétur B Júlíusson, Line Kristin Johnson, Jens Kristoffer Hertel, Samira Lekhal, Jøran Hjelmesæth
BACKGROUND: Obesity during adolescence is associated with cardiovascular mortality in adulthood. The adverse obesity-related cardiometabolic risk profile is already observed in adolescence. We aimed to examine possible gender differences in cardiometabolic risk factors and lifestyle behaviors among adolescents with severe obesity, hypothesizing that boys would have both a higher prevalence of the metabolic syndrome as well as less healthy lifestyle behaviors than girls. METHODS: Cross-sectional study of treatment-seeking adolescents with severe obesity who attended the Morbid Obesity Centre at Vestfold Hospital Trust and who were consecutively enrolled in the Vestfold Register of Obese Children between September 2009 and September 2015...
February 14, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29441322/effect-of-vitamin-e-and-omega-3-fatty-acids-in-type-2-diabetes-mellitus-patients
#8
Ashwitha Shruti Dass, Sarala Narayana, P N Venkatarathnamma
Diabetes mellitus (DM) and its complications have been implicated in hyperglycemia-induced oxidative stress. Antioxidants can improve glycemic control, lipid profile, and cognitive functions. We assessed the effect of Vitamin E and omega 3 fatty acids (OFA) on the above parameters. One hundred patients with type 2 DM receiving metformin 500 mg and glimepiride 1 mg were randomized to receive add-on therapy of Vitamin E 400 mg or OFA once daily for 12 weeks and the third group served as control. Fasting blood sugar (FBS), postprandial blood sugar (PPBS), glycated hemoglobin (HbA1c), body mass index (BMI), waist-hip ratio (WHR), lipid profile, and mini-mental state examination were done at baseline and 12 weeks...
January 2018: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29434857/correlation-between-tap-detection-and-common-digestive-tract-precancerous-lesions
#9
Changqing Sun, Fang Deng, Lingjun Meng, Guohua Chen
The aim of the present study was to investigate the clinical significance of abnormal sugar-chain glycoprotein tumor abnormal protein (TAP) in the screening of common digestive tract pre-cancer colon adenocarcinoma lesions. A total of 50 colitis patients, 50 colon polyp patients and 50 colon adenocarcinoma patients admitted to our hospital from March, 2012 to May, 2014 were included. Fresh blood from patient's fingertips was collected and condensation staining was used to detect TAP expression. Positive expressions of TAP in patients in the colitis, colon polyp and colon adenocarcinoma groups prior to treatment were 6,76 and 92%, respectively...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433574/association-between-diet-quality-dietary-patterns-and-cardiometabolic-health-in-australian-adults-a-cross-sectional-study
#10
Katherine M Livingstone, Sarah A McNaughton
BACKGROUND: Diet quality indices score dietary intakes against recommendations, whereas dietary patterns consider the pattern and combination of dietary intakes. Studies evaluating both methodologies in relation to cardiometabolic health in a nationally representative sample are limited. The aim of the present study was to investigate the relationship between diet quality, dietary patterns and markers of cardiometabolic health in Australian adults. METHODS: Dietary data, using two 24-h dietary recalls, were collected from adults in the cross-sectional Australian Health Survey 2011-2013 (n = 2121; 46...
February 12, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29431100/sheehan-s-syndrome-presenting-as-cardiac-tamponade
#11
Ankit Mittal, Animesh Ray, Ram Manohar Talupula, Rita Sood
A 50-year-old woman presented with progressive dyspnoea and oedema with rapid deterioration over the last few days. Clinical examination revealed hypotension with cold clammy skin, raised jugular venous pressure and muffled heart sounds and was diagnosed to have cardiac tamponade, later confirmed on two-dimensional echocardiography. However, patient had bradycardia, and the other striking examination findings were coarse facies with pallor, madarosis, absent axillary and pubic hair and breast atrophy. Her blood sugar level was also low...
February 3, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29430727/the-sda-and-cad-glycan-antigens-and-their-glycosyltransferase-%C3%AE-1-4galnact-ii-in-xenotransplantation
#12
REVIEW
Chengjiang Zhao, David K C Cooper, Yifan Dai, Hidetaka Hara, Zhiming Cai, Lisha Mou
Antibody-mediated rejection is a barrier to the clinical application of xenotransplantation, and xenoantigens play an important role in this process. Early research suggested that N-acetyl-D-galactosamine (GalNAc) could serve as a potential xenoantigen. GalNAc is the immunodominant glycan of the Sda antigen. Recently, knockout of β1,4-N-acetylgalactosaminyltransferase 2 (β1,4GalNAcT-II) from the pig results in a decrease in binding of human serum antibodies to pig cells. It is believed that this is the result of the elimination of the GalNAc on the Sda antigen, which is catalyzed by the enzyme, β1,4GalNAcT-II...
February 11, 2018: Xenotransplantation
https://www.readbyqxmd.com/read/29430681/effects-of-p-o-administered-xylitol-in-cats
#13
Á Jerzsele, Z Karancsi, E Pászti-Gere, Á Sterczer, A Bersényi, K Fodor, D Szabó, P Vajdovich
Xylitol is commonly used as sugar substitute in households. While it has numerous beneficial effects on human health, it is highly toxic to dogs. The goal of this study was to examine whether xylitol has similar deleterious effects, such as hypoglycaemia and acute hepatic failure, on cats. Our research included six healthy middle-aged cats. Xylitol was dissolved in deionized water and administered p.o. at three doses (100, 500 and 1,000 mg/kg body weight). These dosages have been considered toxic and can cause liver failure or even death in dogs...
February 11, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29430413/an-evaluation-of-the-impact-of-antidiabetic-medication-on-treatment-satisfaction-and-quality-of-life-in-patients-of-diabetes-mellitus
#14
Richa Chaturvedi, Chetna Desai, Prakruti Patel, Asha Shah, Ram K Dikshit
Aims: This study aims to measure the quality of life (QOL), treatment satisfaction, and tolerability of antidiabetic drugs in patients suffering from type 2 diabetes mellitus (DM). Methods: The prospective, observational study was conducted in consenting patients of type 2 DM attending the outpatient department of a tertiary care hospital in Western India. The QOL instrument for Indian diabetes (QOLID) patients questionnaire and the Diabetes Treatment Satisfaction Questionnaire were administered to all patients at baseline, 3 months, and 6 months of treatment...
January 2018: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/29427694/pregnancy-outcomes-in-women-with-an-early-diagnosis-of-gestational-diabetes-mellitus
#15
Maisa N Feghali, Kaleab Z Abebe, Diane M Comer, Steve Caritis, Janet M Catov, Christina M Scifres
AIM: To examine pregnancy outcomes in women with gestational diabetes mellitus (GDM) based on the timing of diagnosis. METHOD: We compared demographics, blood sugars and outcomes between women diagnosed before (n=167) or after 24 weeks' gestation (n=1202) in a single hospital between 2009 and 2012. Because early screening is risk-based we used propensity score modelling and conditional logistic regression to account for systematic differences. RESULTS: Women diagnosed with GDM before 24 weeks were more likely to be obese and they were less likely to have excess gestational weight gain (35 vs...
February 7, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29425646/immunomodulatory-hemolytic-and-cytotoxic-activity-potentials-of-triterpenoid-saponins-from-eight-cephalaria-species
#16
Nazli Boke Sarikahya, Ayse Nalbantsoy, Hilal Top, Ramazan Suleyman Gokturk, Huseyin Sumbul, Suheyla Kirmizigul
BACKGROUND: Saponins isolated from a number of plants possess a broad spectrum of biological and pharmacological activities by using in vitro and in vivo bioassays. The recent investigations and findings in biological activity studies of saponins have mostly focused on immunomodulatory, hemolytic and cytotoxic properties. HYPOTHESIS/PURPOSE: Considering the great potential of saponins as bioactive agents, we investigated the cytotoxic, hemolytic and immunomodulatory activities of nineteen triterpenoid saponins from the aerial parts of eight Cephalaria species from Turkey...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29425477/potential-cardioprotective-effects-of-sumac-capsule-in-patients-with-hyperlipidemia-a-triple-blind-randomized-placebo-controlled-crossover-trial
#17
Sedigheh Asgary, Leila Salehizadeh, Mahtab Keshvari, Marzieh Taheri, Nicholas D Spence, Maryam S Farvid, Mahmoud Rafieian-Kopaei, Nizal Sarrafzadegan
OBJECTIVE: Alternative medicine and herbal drugs have been taken into account for managing cardiovascular risk factors. Sumac (Rhus coriaria L.) is rich in biologically active ingredients known to improve cardiovascular health. We investigated the effect of sumac on systolic (SBP) and diastolic (DBP) blood pressure, flow-mediated dilation (FMD), body mass index (BMI), and serum concentrations of lipids and fasting blood sugar (FBS) in participants with hyperlipidemia in a triple-blind randomized placebo- controlled crossover trial...
February 9, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29425256/dihydromyricetin-improves-type-2-diabetes-induced-cognitive-impairment-via-suppressing-oxidative-stress-and-enhancing-brain-derived-neurotrophic-factor-mediated-neuroprotection-in-mice
#18
Hongyan Ling, Zemei Zhu, Jihua Yang, Jianqin He, Sisi Yang, Di Wu, Shuidong Feng, Duanfang Liao
Type 2 diabetes mellitus (T2DM) leads to cognitive impairment (CI), but there have been no effective pharmacotherapies or drugs for cognitive dysfunction in T2DM. Dihydromyricetin (DHM) is a natural flavonoid compound extracted from the leaves of Ampelopsis grossedentata and has various pharmacological effects including anti-oxidant and anti-diabetes. Thus, we investigated the effects of DHM on CI in T2DM mouse model and its possible mechanism. To induce T2DM, mice were fed with high-sugar and high-fat diet for 8 weeks, followed by a low dose streptozotocin (STZ) administration...
February 7, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29423387/the-effect-of-soluble-fiber-supplementation-on-metabolic-syndrome-profile-among-newly-diagnosed-type-2-diabetes-patients
#19
Ayman S Abutair, Ihab A Naser, Amin T Hamed
Diets with high fiber content improve most metabolic syndrome (MetS) profile in non-diabetic individuals, but there is scarce information about the role of fiber intake in patients with the MetS and diabetes. The objective of this study is to determine whether soluble fiber supplementation improve MetS profile for 8 weeks of intervention in newly diagnosed type 2 diabetes (T2D) adult patients. After one week of dietary stabilization phase, 36 newly diagnosed T2D patients were stratified to different strata according to sex, age, fasting blood sugar (FBS), and waist circumference (WC)...
January 2018: Clinical Nutrition Research
https://www.readbyqxmd.com/read/29422741/cardiopulmonary-and-metabolic-effects-of-yoga-in-healthy-volunteers
#20
T Satheesh Divya, M T Vijayalakshmi, K Mini, K Asish, M Pushpalatha, Varun Suresh
Background: Yoga the spiritual union of mind with the divine intelligence of the universe aims to liberate a human being from conflicts of body-mind duality. Beneficial cardiovascular and pulmonary effects of yoga are in par with aerobic exercise, even amounting to replace the exercise model. We conducted an interventional study in healthy volunteers, to analyze the impact of short-term yoga training on cardiovascular, pulmonary, autonomic function tests, lipid profile, and thyroid function tests...
September 2017: International Journal of Yoga
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