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https://www.readbyqxmd.com/read/28334027/metformin-inhibits-gastric-cancer-cells-metastatic-traits-through-suppression-of-epithelial-mesenchymal-transition-in-a-glucose-independent-manner
#1
Shiva Valaee, Mohammad Mehdi Yaghoobi, Mehdi Shamsara
Epithelial-mesenchymal transition (EMT), which is mainly recognized by upregulation of mesenchymal markers and movement of cells, is a critical stage occurred during embryo development and spreading cancerous cells. Metformin is an antidiabetic drug used in treatment of type 2 diabetes. EMT inhibitory effect of metformin has been studied in several cancers; however, it remains unknown in gastric cancer. The aim of the present study was to investigate the metformin effects on inhibition of EMT-related genes as well as migration and invasion of AGS gastric cancer cell line...
2017: PloS One
https://www.readbyqxmd.com/read/28333551/effect-of-a-group-behavioural-management-program-on-emotional-regulation-of-food-choices-a-pilot-randomized-controlled-trial
#2
Danuta Southgate, Michelle Greiver, Greg Hubka, Kori Kostka, Rahim Moineddin, Marjan Moienedin, James Pencharz, Heather Bogetta, Claudia Mazariegos, Jo-Anne Guindon, Andrea Petroff
PURPOSE: In Ontario, group programs to increase mindfulness of food choices are provided in Family Health Teams (FHTs), but evaluation is limited. We targeted patients with chronic conditions that could benefit from intensified management and evaluated an existing program. METHODS: We included 3 FHTs. Patients were randomized to immediate participation in the intervention (n = 16) or to wait-list control (n = 14). Eligible participants were between 40 and 70 years old, living with diabetes and/or hypertension and had at least 2 of: elevated cholesterol (LDL >4 if hypertension or LDL >2 mmol/L if diabetes), blood sugar (A1c >7...
March 23, 2017: Canadian Journal of Dietetic Practice and Research
https://www.readbyqxmd.com/read/28333388/central-regulation-of-glucose-homeostasis
#3
Alexander Tups, Jonas Benzler, Domenico Sergi, Sharon R Ladyman, Lynda M Williams
The ability of the brain to directly control glucose levels in the blood independently of its effects on food intake and body weight has been known ever since 1854 when Claude Bernard, a French physiologist, discovered that lesioning the floor of the fourth ventricle in rabbits led to a rise of sugar in the blood. Despite this outstanding discovery at that time, it took more than 140 years before progress started to be made in identifying the underlying mechanisms of brain-mediated control of glucose homeostasis...
March 16, 2017: Comprehensive Physiology
https://www.readbyqxmd.com/read/28332908/the-association-between-triglyceride-high-density-lipoprotein-cholesterol-ratio-and-benign-prostate-hyperplasia-in-non-diabetic-patients-a-cross-sectional-study
#4
Huseyin Besiroglu, Murat Dursun, Alper Otunctemur, Emin Ozbek
OBJECTIVES: To assess the association between triglyceride (TG)/high density lipoprotein (HDL) ratio and benign prostate hyperplasia/lower urinary tract symptoms (BPH/LUTS). METHODS: Four hundred patients who were admitted to the Urology Clinic between January and December 2014 with complaints of BPH/LUTS were enrolled in this cross-sectional study. Patients were divided into two groups according to their International Prostate Symptom Score and prostate volume (PV)...
March 23, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28330724/treatment-effects-and-mechanisms-of-yujin-powder-on-rat-model-of-large-intestine-dampness-heat-syndrome
#5
Wanling Yao, Chaoxue Yang, Yanqiao Wen, Wangdong Zhang, Xiaosong Zhang, Qi Ma, Peng Ji, Yongli Hua, Yanming Wei
ETHNOPHARMACOLOGICAL RELEVANCE: Yujin Powder (YJP), an old prescription, is one of the most classical prescription for treating the large intestine dampness-heat syndrome (LIDHS). However, its potential modern pharmacological mechanisms remain unclear. AIM OF THE STUDY: The present study was designed to explore the essence of LIDHS and treatment mechanisms of the YJP on the LIDHS. METHODS: The rat model of LIDHS was established by such complex factors as high-sugar and high-fat diet, improper diet, high temperature and humidity environment (HTHE), drinking and intraperitoneal injection of Escherichia coli...
March 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28330678/acute-macular-edema-and-peripapillary-soft-exudate-after-pancreas-transplantation-with-accelerated-progression-of-diabetic-retinopathy
#6
Fang-Yi Tsai, Ling-Ing Lau, An-Fei Li, Shih-Jen Chen, Shin-E Wang, Fenq-Lih Lee, Catherine Jiu-Lin Liu, Yi-Ming Shyr
BACKGROUND: The effect of pancreas transplantation on diabetic retinopathy remains inconclusive. Herein, we report six patients with type 1 diabetes mellitus (DM) who underwent pancreas transplantation and developed acute macular edema and peripapillary soft exudate with rapid progression to proliferative diabetic retinopathy. METHODS: In this retrospective observational study, diabetic patients who underwent pancreas transplantation in a single medical center and developed symptomatic acute macular edema and peripapillary soft exudate within 3 months after the operation were enrolled...
March 18, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28328988/molecular-mechanisms-of-thermal-resistance-of-the-insect-trypanosomatid-crithidia-thermophila
#7
Aygul Ishemgulova, Anzhelika Butenko, Lucie Kortišová, Carolina Boucinha, Anastasiia Grybchuk-Ieremenko, Karina A Morelli, Martina Tesařová, Natalya Kraeva, Danyil Grybchuk, Tomáš Pánek, Pavel Flegontov, Julius Lukeš, Jan Votýpka, Márcio Galvão Pavan, Fred R Opperdoes, Viktoria Spodareva, Claudia M d'Avila-Levy, Alexei Yu Kostygov, Vyacheslav Yurchenko
In the present work, we investigated molecular mechanisms governing thermal resistance of a monoxenous trypanosomatid Crithidia luciliae thermophila, which we reclassified as a separate species C. thermophila. We analyzed morphology, growth kinetics, and transcriptomic profiles of flagellates cultivated at low (23°C) and elevated (34°C) temperature. When maintained at high temperature, they grew significantly faster, became shorter, with genes involved in sugar metabolism and mitochondrial stress protection significantly upregulated...
2017: PloS One
https://www.readbyqxmd.com/read/28326343/n-acetylglucosamine-suppresses-osteoclastogenesis-in-part-through-the-promotion-of-o-glcnacylation
#8
Tomoharu Takeuchi, Moyuko Nagasaka, Miyuki Shimizu, Mayumi Tamura, Yoichiro Arata
Osteoclasts are the only cells in an organism capable of resorbing bone. These cells differentiate from monocyte/macrophage lineage cells upon stimulation by receptor activator of NF-κB ligand (RANKL). On the other hand, osteoclastogenesis is reportedly suppressed by glucose via the downregulation of NF-κB activity through suppression of reactive oxygen species generation. To examine whether other sugars might also affect osteoclast development, we compared the effects of monomeric sugars (glucose, galactose, N-acetylglucosamine (GlcNAc), and N-acetylgalactosamine (GalNAc)) on the osteoclastogenesis of murine RAW264 cells...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28325823/video-conferences-preceded-by-uploading-of-measurements-as-add-on-to-standard-care-among-patients-with-type-2-diabetes-not-responding-to-standard-regimens-a-randomized-controlled-trial
#9
Caroline Raun Hansen, Hans Perrild, Birgitte Gade Koefoed, Mette Zander
OBJECTIVE: To examine whether video consultations preceded by measurements of blood glucose, weight and blood pressure as add-on to standard care could contribute to achieving and maintaining good diabetes control among patients with poorly regulated type 2 diabetes (T2D). DESIGN: Randomized controlled trial. METHODS: 165 patients with T2D were randomized 1:1 to telemedicine intervention as add-on to clinic based care or control (clinic based care)...
March 21, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28323393/evaluation-of-antidiabetic-activity-of-biologically-synthesized-silver-nanoparticles-agnps-using-pouteria-sapota-on-stz-induced-diabetic-rats
#10
Sathya Prabhu, Shanmugam Vinodhini, Chakravarthy Elenchezhiyan, Devi Rajeswari
BACKGROUND: Medicinal plants and green synthesis of silver nanoparticles (AgNPs) have proven to be potent source effective agents in the treatment of diabetes mellitus. The present study is focused on the green synthesis of AgNPs from aqueous leaf extract of Pouteria sapota (P. sapota) in order to evaluate the in-vitro and in-vivo anti-diabetic property of aqueous extracts and their synthesized AgNPs. METHODS: AgNPs were biologically synthesized under ambient conditions from an aqueous leaf extract of P...
March 21, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28321313/correlation-study-of-adenosine-deaminase-and-its-isoenzymes-in-type-2-diabetes-mellitus
#11
Lokendra Bahadur Sapkota, Sangita Thapa, Nuwadatta Subedi
OBJECTIVE: Adenosine deaminase (ADA) plays an important role in cell-mediated immunity and modulation of insulin activity. Its clinical and diagnostic significance in Nepalese type 2 diabetes is not yet characterized. So, this study's objective was to determine the isoenzymatic activities of ADA (ADA1, ADA2, and total ADA) and show its correlation with demographic, anthropometric, and biochemical characteristics of type 2 Nepalese subjects with diabetes. RESEARCH DESIGN AND METHODS: This is a hospital-based cross-sectional study including 80 type 2 diabetes mellitus (DM) patients and same number of age-matched and sex-matched healthy controls...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28321030/pancreas-volume-reduction-and-metabolic-effects-in-japanese-patients-with-severe-obesity-following-laparoscopic-sleeve-gastrectomy
#12
Akira Umemura, Akira Sasaki, Hiroyuki Nitta, Shigeaki Baba, Taro Ando, Takashi Kajiwara, Yasushi Ishigaki
This study aimed to assess the relationship between the metabolic effect after laparoscopic sleeve gastrectomy (LSG) in morbidly obese Japanese patients, with or without type 2 diabetes mellitus (T2DM), and improved pancreatic steatosis (PS). The study enrolled 27 morbidly obese Japanese patients who were undergoing LSG. Their clinical and metabolic effects were evaluated at baseline and six months after LSG. Pancreas volume (PV), pancreatic attenuation (PA), and splenic attenuation (SA) were measured using a 64-row computed tomography (CT)...
March 17, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28320601/coronary-atherosclerosis-in-indigenous-south-american-tsimane-a-cross-sectional-cohort-study
#13
Hillard Kaplan, Randall C Thompson, Benjamin C Trumble, L Samuel Wann, Adel H Allam, Bret Beheim, Bruno Frohlich, M Linda Sutherland, James D Sutherland, Jonathan Stieglitz, Daniel Eid Rodriguez, David E Michalik, Chris J Rowan, Guido P Lombardi, Ram Bedi, Angela R Garcia, James K Min, Jagat Narula, Caleb E Finch, Michael Gurven, Gregory S Thomas
BACKGROUND: Conventional coronary artery disease risk factors might potentially explain at least 90% of the attributable risk of coronary artery disease. To better understand the association between the pre-industrial lifestyle and low prevalence of coronary artery disease risk factors, we examined the Tsimane, a Bolivian population living a subsistence lifestyle of hunting, gathering, fishing, and farming with few cardiovascular risk factors, but high infectious inflammatory burden. METHODS: We did a cross-sectional cohort study including all individuals who self-identified as Tsimane and who were aged 40 years or older...
March 16, 2017: Lancet
https://www.readbyqxmd.com/read/28317764/cucurbitane-glycosides-from-the-fruit-of-siraitia-grosvenori-and-their-effects-on-glucose-uptake-in-human-hepg2-cells-in-vitro
#14
Fu Li, Fumei Yang, Xin Liu, Lun Wang, Bin Chen, Lianhong Li, Mingkui Wang
The mogrosides in the fruit of Siraitia grosvenori can serve as a sugar substitute for diabetics due to their sweetness, low calorie and positive effects on blood glucose level control. The present study was to purify the mogrosides from the fruit of S. grosvenori and evaluate their enhancement of glucose uptake rate in HepG2 cells in vitro. As a result, eighteen mogrosides were isolated, including six new ones and a known but new naturally occurring compound. The chemical structures of the new compounds were identified by 1D, 2D-NMR and HR-ESI-MS techniques, together with chemical methods...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28304103/utilization-of-potato-peels-and-sugar-beet-pulp-with-and-without-enzyme-supplementation-in-broiler-chicken-diets-effects-on-performance-serum-biochemical-indices-and-carcass-traits
#15
H M Abdel-Hafeez, E S E Saleh, S S Tawfeek, I M I Youssef, A S A Abdel-Daim
This study was conducted to investigate the effects of including potato peels (PP) and sugar beet pulp (SBP), as unconventional feeds, with and without enzyme in broiler diets from 1 to 42 days of age by observing the growth performance, blood parameters and carcass characteristics. A total of 150, 1-day old, chicks were randomly assigned into five groups, each with 30 chicks. Birds in group 1 were fed on the control diet. Chicks in groups 2 and 3 were offered diets containing PP and SBP at the rate of 15% and 7...
March 17, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28303994/association-of-il-6-c-174g-rs-1800795-single-nucleotide-polymorphism-with-type-2-diabetes-mellitus-in-pakistani-population
#16
Amina Nadeem, Sadaf Mumtaz, Abdul Khaliq Naveed, Qaiser Mansoor, Muhammad Aslam, Arif Siddiqui, Muhammad Ismail
OBJECTIVE: To determine the association of interleukin-6 C-174G single nucleotide polymorphism with type 2 diabetes mellitus and metabolic parameters. METHODS: This case-control study was conducted from June 2012 to December 2013 at the Military Hospital Rawalpindi, the Centre for Research in Experimental and Applied Medicine, Army Medical College, Rawalpindi, and the Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan. Two cohorts of subjects were genotyped for the single nucleotide polymorphism...
March 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28301961/current-management-of-necrotising-otitis-externa-in-the-uk-survey-of-221-uk-otolaryngologists
#17
Gaurav Chawdhary, Miran Pankhania, Susan Douglas, Ian Bottrill
INTRODUCTION: Necrotising otitis externa (NOE) is a rare infection causing skull base osteomyelitis. The evidence regarding NOE consists mostly of case series. Hence, there is a limited evidence base to guide decision-making. This survey aims to report the experience of 221 otolaryngologists in this condition. MATERIALS AND METHODS: Internet survey administered to the membership of the British Association of Otorhinolaryngology - Head and Neck Surgery (ENT UK). RESULTS: Respondents' detailed replies on diagnosis, treatment and follow up are presented...
March 16, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28300590/heparin-depolymerization-by-immobilized-heparinase-a-review
#18
REVIEW
Indu Bhushan, Alhumaidi Alabbas, Jyothi C Sistla, Rashmi Saraswat, Umesh R Desai, Ram B Gupta
Heparin is a member of the glycosaminoglycan (GAG) family composed of glucosamine and uronic acid units containing O-sulfo, N-acetyl and N-sulfo groups, which are alternating in the chain and linked by 1→4 manner. It is a naturally occurring anticoagulant that prevents the formation of clots and their growth within blood. Certain low molecular weight heparins (LMWHs) are considered as better therapeutic agents than natural heparin because of the reduced side effects and smaller risk of bleeding. LMWHs can be produced from heparin by chemical or enzymatic depolymerizations...
March 11, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28291486/a-randomized-controlled-trial-of-nurse-coaching-vs-herbal-supplementation-for-weight-reduction-in-soldiers
#19
Mary S McCarthy, Evelyn B Elshaw, Barbara M Szekely, Curtis Hobbs
The number of overweight and obese service members has tripled since the beginning of Overseas Contingency Operations.1 Overwhelming evidence suggesting links between obesity and increased risk for conditions such as musculoskeletal injuries, type II diabetes, and cardiovascular disease,2 poses a threat to the strength and performance of our current and future fighting force. OBJECTIVE: The purpose of the study was to test nurse health coaching (NHC) and/or herbal supplementation for weight reduction in Soldiers during a 12-week intervention...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28286827/doing-pre-operative-investigations-in-emergency-department-a-clinical-audit
#20
Muhammad Salman Rafiq, Maria Rafiq, Muhammad Imran Rafiq, Seema Gul Salman, Sania Hafeez
INTRODUCTION: Pre-operative investigations for emergency surgical patients differ between centers. Following established guidelines can reduce unnecessary investigation, cost of treatment and hospital stay. The present audit was carried out to evaluate the condition of doing pre-operative investigations for three common surgical emergencies compared to National Institute for Health and Care Excellence (NICE) guidelines and local criteria. METHODS: A retrospective clinical audit of acute-appendicitis, abscess and hernia patients admitted to the emergency department was carried out over a one-year period from July 2014 to July 2015...
2017: Emergency (Tehran, Iran)
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