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https://www.readbyqxmd.com/read/29226729/formulation-of-sitagliptin-loaded-oral-polymeric-nano-scaffold-process-parameters-evaluation-and-enhanced-anti-diabetic-performance
#1
Mohammed Asadullah Jahangir, Ruqaiyah Khan, Syed Sarim Imam
PURPOSE: The aim of the study to formulate and statistically optimize sitagliptin-loaded eudragit nanoparticles (SIT-NPs) and evaluate the in-vitro pharmaceutical quality and in-vivo anti-diabetic assessment. METHOD: SIT-NPs were prepared by using combination method of solvent evaporation and nano-precipitation techniques. The influence of different independent variables as eudragit RL100 concentration (%), tween 80 concentration (%) and sonication time (min) were evaluated on dependent variables like particle size (nm), drug loading (%) and in-vitro drug release (%)...
December 9, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29226712/-risk-stratification-before-thoracic-surgery-perioperative-pulmonary-rehabilitation
#2
Attila Vágvölgyi, Zsolt Rozgonyi, Pál Vadász, János Tamás Varga
INTRODUCTION: Besides the oncology and operative surgical technics, functional aspects influence the operability of lung cancer. Preoperative risk stratification, evaluation of postoperative complications needs to be considered. AIM: To review international literature and experiences of our institute. METHOD: We focused the literature of risk stratification of thoracic surgery. Lung function, lung mechanics, chest kinematics, exercise physiology were considered...
December 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29226480/successful-pancreas-transplantation-alone-is-associated-with-excellent-self-identified-health-score-and-glucose-control-a-retrospective-study-from-a-high-volume-center-in-the-united-states
#3
Joseph R Scalea, Lauren Pettinato, Blythe Fiscella, Amanda Bartosic, Allison Piedmonte, Jastine Paran, Niket Todi, Eric J Siskind, Stephen T Bartlett
BACKGROUND: The benefits of pancreas transplantation are often difficult to measure. Here, we sought to determine the difference in quality of life for diabetic patients with and without a functional pancreas transplant alone (PTA). METHODS: PTA cases from 1993-2015 were considered. An IRB-approved survey inclusive of 15 questions spanning 4 domains was employed. Chi-square, Fischer's exact, and the T-test were used where appropriate. RESULTS: 137 PTAs were performed during the study period...
December 11, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29225896/incidence-of-diabetes-mellitus-and-factors-associated-with-its-development-in-hiv-positive-patients-over-the-age-of-50
#4
Faizal Samad, Marianne Harris, Cathy M Puskas, Monica Ye, Jason Chia, Sarah Chacko, Gregory P Bondy, Viviane D Lima, Julio Sg Montaner, Silvia A Guillemi
Objective: We sought to determine the incidence and factors associated with development of diabetes mellitus (DM) in older HIV-infected individuals. Research design and methods: We analyzed data from people living with HIV (PLWH) ≥50 years of age enrolled in a large urban HIV outpatient clinic in Vancouver, British Columbia. Patients were categorized as having DM if they had random blood sugar ≥11.1 mmol/L, fasting blood sugar ≥7 mmol/L, HbA1C ≥6.5%, antidiabetic medication use during the follow-up period, or medical chart review confirming diagnosis of DM...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29225114/fructose-induced-inflammation-and-increased-cortisol-a-new-mechanism-for-how-sugar-induces-visceral-adiposity
#5
REVIEW
James J DiNicolantonio, Varshil Mehta, Neema Onkaramurthy, James H O'Keefe
Traditionally, the leading hypothesis regarding the development of obesity involves caloric imbalance, whereby the amount of calories consumed exceeds the amount of calories burned which causes obesity. Another hypothesis for why we get fat has surfaced in the last decade which is the idea that the overconsumption of added sugars and refined carbohydrates induce insulin resistance and high insulin levels causing obesity. While insulin is a fat-storing hormone, this hypothesis does not explain visceral adiposity, or why certain people are found to have fat stored in and around their organs...
December 7, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29224633/over-the-counter-medicines-and-diabetes-care
#6
Jeff Taylor
OBJECTIVES: People with diabetes turn to over-the-counter (OTC) medicines for many ailments. The focus of this brief review is the impact common OTC medicines might have on this group of patients. METHODS: Three types of OTC medicines were selected as most deserving of attention: 3 herbal agents, nonsteroidal anti-inflammatory drugs (NSAIDs) and cough/cold products. Existing literature was used to determine precautions that might be in order. RESULTS: Herbal/natural agents with the potential to impact blood sugar have been identified in various reports...
December 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29221543/community-health-workers-in-diabetes-prevention-and-management-in-developing-countries
#7
REVIEW
Halimatou Alaofè, Ibitola Asaolu, Jennifer Ehiri, Hayley Moretz, Chisom Asuzu, Mobolanle Balogun, Olayinka Abosede, John Ehiri
BACKGROUND: There is limited evidence regarding the effect of community health worker (CHW) interventions for prevention and management of the burgeoning epidemic of noncommunicable diseases (NCDs) in low- and middle-income countries (LMICs). The objective of this review was to critically appraise evidence regarding the effectiveness of CHW interventions for prevention and management of type 2 diabetes mellitus (T2DM) in LMICs. METHODS: To identify studies that reported the effect of CHW interventions for prevention and management of T2DM in LMICs, Medline/PubMed, EMBASE, Web of Science (Science and Social Science Citation Indices), EBSCO (PsycINFO and CINAHL), POPLINE, the Cochrane Metabolic and Endocrine Disorders Group's Specialized Register, the Cochrane Central Register of Controlled Trials, the Grey literature (Google, Google Scholar), and reference lists of identified articles were searched from inception to May 31, 2017...
May 2017: Annals of Global Health
https://www.readbyqxmd.com/read/29219130/effects-of-health-education-tool-on-select-epidemiological-factors-associated-with-adult-obese-urban-slum-women
#8
Deepika Pradeep Vora, Pallavi S Shelke
BACKGROUND: National Family Health Survey-3 (2005-2006) India, found that 14.8% of Ever-Married Adults (age 15-49 years) had Body Mass Index (BMI) in the ranges of overweight and obese; compared to 10.6% in the National Family Health Survey-2. These figures highlighted the fact that India already faces a dual burden of chronic malnutrition, i.e., obesity, besides undernutrition. Higher BMI, especially, increased abdominal fat is an important determinant of the development of diabetes...
October 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/29218127/the-effect-of-group-discussion-based-education-on-self-management-of-adults-with-type-2-diabetes-mellitus-compared-with-usual-care-a-randomized-control-trial
#9
Hosein Habibzadeh, Akbar Sofiani, Leyla Alilu, Mark Gillespie
Objectives: We sought to determine the effect of group discussion-based education on the self-management capability of patients with type 2 diabetes in Iran. Methods: This randomized control trial was conducted on 90 patients with type 2 diabetes. Participants were allocated randomly into one of two groups; intervention and control. The intervention group received the group discussion-based education while the control group received routine care only. The Lin's self-management questionnaire was completed at baseline and three months post-intervention...
November 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29218064/non-diabetic-hyperglycemia-and-some-of-its-correlates-in-icu-hospitalized-patients-receiving-enteral-nutrition
#10
Mohammad Amin Valizadeh Hasanloei, Zahra Vahdat Shariatpanahi, Davoud Vahabzadeh, Zakaria Vahabzadeh, Leila Nasiri, Ali Shargh
Introduction: Hyperglycemia is a common occurrence in critically ill patients, and its prevalence in patients receiving nutritional support is much higher than in other patients. The non-diabetic form is associated with more undesirable outcomes. This study was performed to determine the prevalence of non-diabetic hyperglycemia and its correlates in patients receiving enteral nutrition. Material and Methods: This cross-sectional study was performed between March and December 2015...
September 2017: Mædica
https://www.readbyqxmd.com/read/29217920/correlation-between-serum-lipid-profile-with-anthropometric-and-clinical-variables-in-patients-with-type-2-diabetes-mellitus
#11
Belete Biadgo, Solomon Mekonnen Abebe, Habtamu Wondifraw Baynes, Mohammed Yesuf, Aynadis Alemu, Molla Abebe
Background: The problem of dyslipidemia is high in patients with diabetes mellitus. There is ample evidence that abnormalities in lipid metabolism are important risk factors for increased incidence of diabetes associated complications. The most important risk indicators for these complications are lipid profile abnormalities. Therefore, the aim of this study was to assess the correlation between serum lipid profile with anthropometric and clinical variables among type 2 diabetes mellitus patients...
May 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29216950/-effect-of-early-enteral-nutrition-standardized-treatment-on-blood-glucose-and-prognosis-in-acute-respiratory-distress-syndrome-patients-with-mechanical-ventilation
#12
Chunmiao Zhong, Chaohui Ji, Zhuquan Dai, Kai Fu, Xiaohong Wen, Huibin Pan
OBJECTIVE: To study the effect of early entreat nutrition (EN) standardized treatment on optimization of blood glucose control and prognosis in acute respiratory distress syndrome (ARDS) patients with mechanical ventilation (MV). METHODS: Forty-two patients with MV of ARDS admitted to Huzhou First Municipal People's Hospital from April 2015 to March 2017 were enrolled. April 1st, 2016 was taken as the time node, the patients treated from April 1st, 2015 to March 31st, 2016 were assigned in the control group (n = 20), while the patients treated from April 1st, 2016 to March 31st, 2017 were included in the experimental group (n = 22)...
December 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29215581/stress-induced-hyperglycemia-in-diabetes-a-cross-sectional-analysis-to-explore-the-definition-based-on-the-trauma-registry-data
#13
Cheng-Shyuan Rau, Shao-Chun Wu, Yi-Chun Chen, Peng-Chen Chien, Hsiao-Yun Hsieh, Pao-Jen Kuo, Ching-Hua Hsieh
Background: The diagnosis of diabetic hyperglycemia (DH) does not preclude a diabetes patient from having a stress-induced hyperglycemic response. This study aimed to define the optimal level of elevated glucose concentration for determining the occurrence of stress-induced hyperglycemia (SIH) in patients with diabetes. Methods: This retrospective study reviewed the data of all hospitalized trauma patients, in a Level I trauma center, from 1 January 2009 to 31 December 2016. Only adult patients aged ≥20 years, with available data on serum glucose and glycated hemoglobin A1c (HbA1c) levels upon admission, were included in the study...
December 7, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29215310/apolipoprotein-e4-mediates-insulin-resistance-associated-cerebrovascular-dysfunction-and-the-post-prandial-response
#14
Lance A Johnson, Eileen Ruth Torres, Sydney Weber Boutros, Esha Patel, Tunde Akinyeke, Nabil J Alkayed, Jacob Raber
Metabolic dysfunction, commonly a result of diets high in saturated fats and sugar, is associated with impaired cognitive function and an increased risk of age-related cognitive decline (ACD) and Alzheimer's disease (AD). Compared to the E3 isoform of apolipoprotein (apoE), the E4 isoform is a major genetic risk factor for ACD, AD, and for developing cognitive impairments following various environmental challenges, including dietary challenges such as a high-fat diet (HFD). Both insulin resistance (IR) and E4 are associated with metabolic and vascular impairments...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29214183/direct-and-indirect-effects-of-serum-uric-acid-on-blood-sugar-levels-in-patients-with-prediabetes-a-mediation-analysis
#15
Thunyarat Anothaisintawee, Dumrongrat Lertrattananon, Sangsulee Thamakaison, Sirimon Reutrakul, Boonsong Ongphiphadhanakul, Ammarin Thakkinstian
Purpose: To estimate both direct and indirect effects (through obesity) of serum uric acid (SUA) on blood sugar in prediabetes patients. Methods: Prediabetes patients who came to the outpatient clinic of the Department of Family Medicine, Ramathibodi Hospital, were included in this cross-sectional study. Mediation analysis was applied to determine direct and indirect effects of SUA on glycemic parameters (fasting plasma glucose (FPG) and HbA1c) through waist circumference (WC)...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29212760/large-scale-molecular-dynamics-simulation-of-coupled-dynamics-of-flow-and-glycocalyx-towards-understanding-atomic-events-on-an-endothelial-cell-surface
#16
Xi Zhuo Jiang, Haipeng Gong, Kai Hong Luo, Yiannis Ventikos
The glycocalyx has a prominent role in orchestrating multiple biological processes occurring at the plasma membrane. In this paper, an all-atom flow/glycocalyx system is constructed with the bulk flow velocity in the physiologically relevant ranges for the first time. The system is simulated by molecular dynamics using 5.8 million atoms. Flow dynamics and statistics in the presence of the glycocalyx are presented and discussed. Complex dynamic behaviours of the glycocalyx, particularly the sugar chains, are observed in response to blood flow...
December 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29210863/prevalence-awareness-treatment-and-control-of-hypertension-among-rural-and-urban-dwellers-of-the-far-north-region-of-cameroon
#17
Daniel Lemogoum, Philippe Van de Borne, Claude Elysée Bika Lele, Albertino Damasceno, William Ngatchou, Pierre Amta, Marc Leeman, Nicolas Preumont, Jean-Paul Degaute, Felicité Kamdem, Michel P Hermans, Philippe Donnen, Pascal Bovet
OBJECTIVE: To assess the prevalence and determinants of high blood pressure (BP) and awareness, treatment, and control rates in the Far North Region of Cameroon, where these variables have not been explored so far. METHODS: In total, 889 individuals (41.5% women) aged at least 18 years participated in a cross-sectional survey conducted in Maroua (urban area) and Tokombere (rural area) from November 2014 to May 2015, using a multistage cluster sampling frame. Anthropometric variables, BP, and fasting capillary glucose were assessed in all participants...
January 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29209937/sugar-based-collagen-membrane-cross-linking-increases-barrier-capacity-of-membranes
#18
Po-Ju Chia-Lai, Anna Orlowska, Sarah Al-Maawi, Andre Dias, Yunxin Zhang, Xuejiu Wang, Niklas Zender, Robert Sader, C James Kirkpatrick, Shahram Ghanaati
OBJECTIVES: This study examines the permeability and barrier capacity of a sugar cross-linked resorbable collagen membrane ex vivo and in vivo. MATERIALS AND METHODS: In an ex vivo study, injectable platelet-rich fibrin (i-PRF), a peripheral blood-derived human leukocyte-and-platelet-rich plasma was used to analyze membrane permeability. in vivo subcutaneous implantation in Wistar rats (n = 4 per time point and group) was used to investigate the barrier capacity of the membrane...
December 6, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29207752/study-of-left-ventricular-mass-and-its-determinants-on-echocardiography
#19
Namrata Guleri, Susheela Rana, Randhir S Chauhan, Prakash Chand Negi, Yogesh Diwan, Deepa Diwan
Introduction: Increased Left Ventricular Mass (LVM) is an independent risk factor for cardiovascular morbidity and mortality. Aim: This study was done to find the prevalence and determinants of LVM in the Northern Indian population. Materials and Methods: A prospective cross-sectional observational study was carried out in a tertiary care centre in Himachal Pradesh, India and the study population included all consecutive patients fulfilling the inclusion criteria attending cardiology OPD on seeking medical attention with various symptoms for dyslipidaemia, hypertension but not on medication over a period of one year...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207741/prevalence-of-chronic-morbidity-and-sociodemographic-profile-of-police-personnel-a-study-from-gujarat
#20
Kishankumar Maheshkumar Bhatia, Niraj Pandit
Introduction: The police personnel are special group of population that work for minimum 12 hours a day. They are at risk of various types of chronic morbidities. Aim: To determine the sociodemographic, chronic morbidity and health profile of police personnel of Vadodara district. Materials and Methods: It was a cross-sectional study conducted on the police force of Vadodara district, Gujarat, India. The present study was the outcome of health checkup camp for police personnel...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
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