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https://www.readbyqxmd.com/read/29665394/maca-polysaccharides-extraction-optimization-structural-features-and-anti-fatigue-activities
#1
Yujuan Li, Yizhou Xin, Fangxue Xu, Mengmeng Zheng, Xiaozhi Xi, Xiaowei Cui, Hui Cao, Hong Guo, Chunchao Han
The maca polysaccharides optimal extraction conditions were obtained by using response surface methodology (RSM) method and the anti-fatigue activity of maca polysaccharides (MCP) was explored. The maca polysaccharides extract yield of RSM could reach 9.97 mg/g by using the model predicts, and the total sugar and protein purity were 61.00% and 4.46% with the further isolation process, respectively. And the monosaccharide compositions obtained by gas chromatograph (GC) were composed of rhamnose (rha), glucose (glc), galactose (gal) with the ratio of 2...
April 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29665363/isoquercetin-ameliorates-hyperglycemia-and-regulates-key-enzymes-of-glucose-metabolism-via-insulin-signaling-pathway-in-streptozotocin-induced-diabetic-rats
#2
Muthukumaran Jayachandran, Tongze Zhang, Kumar Ganesan, Baojun Xu, Stephen Sum Man Chung
Among the foremost common flavonoids within the human diet, quercetin glycosides possess neuroprotective, cardioprotective, anti-oxidative, chemopreventive, and anti-allergic properties. Isoquercetin is one such promising candidate with anti-diabetic potential. However, complete studies of its molecular action on insulin signaling pathway and carbohydrate metabolizing enzymes remain unclear. Hence, we have designed this study to accumulate the experimental evidence in support of anti-diabetic effects of isoquercetin...
April 14, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29661175/adherence-to-the-qatar-dietary-guidelines-a-cross-sectional-study-of-the-gaps-determinants-and-association-with-cardiometabolic-risk-amongst-adults
#3
Mohammed Al Thani, Al Anoud Al Thani, Walaa Al-Chetachi, Badria Al Malki, Shamseldin A H Khalifa, Ahmad Haj Bakri, Nahla Hwalla, Farah Naja, Lara Nasreddine
BACKGROUND: The Qatar Dietary Guidelines (QDGs) were developed as part of the national strategy to prevent chronic diseases. This study aims at characterizing gaps between the QDGs and usual dietary and lifestyle patterns in Qatar, identifying demographic and socioeconomic determinants of adherence to the QDGs and investigating the association between adherence and cardiometabolic risk. METHODS: This study is based on the Qatar National STEPwise cross-sectional survey which was conducted on a nationally representative sample of Qatari adults, aged 18 to 64 years (n = 1109)...
April 16, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29659965/a-healthy-asian-a-posteriori-dietary-pattern-correlates-with-a-priori-dietary-patterns-and-is-associated-with-cardiovascular-disease-risk-factors-in-a-multiethnic-asian-population
#4
Clare Whitton, Salome A Rebello, Jeannette Lee, E Shyong Tai, Rob M van Dam
Background: Healthful dietary patterns are associated with cardiovascular disease risk factors in Western populations. However, a consistent healthful dietary pattern across major Asian ethnic groups has yet to be identified. Objective: We aimed to identify a posteriori dietary patterns for Chinese, Malay, and Indian ethnic groups in an urban Asian setting, compare these with a priori dietary patterns, and ascertain associations with cardiovascular disease risk factors including hypertension, obesity, and abnormal blood lipid concentrations...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29659691/perspective-cardiovascular-responses-to-sugar-sweetened-beverages-in-humans-a-narrative-review-with-potential-hemodynamic-mechanisms
#5
Cathriona R Monnard, Erik Konrad Grasser
Cardiovascular diseases are still the primary cause of mortality worldwide, with high blood pressure and type 2 diabetes as major promoters. Over the past 3 decades, almost in parallel with the rise in cardiovascular disease incidence, the consumption of sugar-sweetened beverages (SSBs) has increased. In this context, SSBs are potential contributors to weight gain and increase the risk for elevations in blood pressure, type 2 diabetes, coronary heart disease, and stroke. Nevertheless, the mechanisms underlying the cardiovascular and metabolic responses to SSBs, in particular on blood pressure, are poorly understood...
March 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29659536/glucose-sensor-using-u-shaped-optical-fiber-probe-with-gold-nanoparticles-and-glucose-oxidase
#6
Kuan-Chieh Chen, Yu-Le Li, Chao-Wei Wu, Chia-Chin Chiang
In this study, we proposed a U-shaped optical fiber probe fabricated using a flame heating method. The probe was packaged in glass tube to reduce human factors during experimental testing of the probe as a glucose sensor. The U-shaped fiber probe was found to have high sensitivity in detecting the very small molecule. When the sensor was dipped in solutions with different refractive indexes, its wavelength or transmission loss changed. We used electrostatic self-assembly to bond gold nanoparticles and glucose oxidase (GOD) onto the sensor’s surface...
April 16, 2018: Sensors
https://www.readbyqxmd.com/read/29655779/postprandial-glucose-and-insulin-response-to-a-high-fiber-muffin-top-containing-resistant-starch-type-4-in-healthy-adults-a-double-blind-randomized-controlled-trial
#7
Maria L Stewart, J Paul Zimmer
OBJECTIVES: VERSAFIBE™ 2470 resistant starch (RS) is an RS type 4 that is derived from high-amylose maize starch,70% total dietary fiber (TDF; AOAC method 2009.01). This was a randomized, double-blind, crossover study to evaluate the postprandial blood glucose and insulin responses of healthy adults (n = 28) after the consumption of a muffin top made with VERSAFIBE™ 2470 RS (11.6 g TDF fiber muffin top) or a control muffin top (0.9 g TDF). METHODS: The muffin tops were matched for weight, total carbohydrate, sugars, protein, and fat...
February 13, 2018: Nutrition
https://www.readbyqxmd.com/read/29652278/effects-of-glargine-insulin-on-glycemic-control-in-patients-with-diabetes-mellitus-type-ii-undergoing-off-pump-coronary-artery-bypass-graft
#8
Hemang Gandhi, Alpesh Sarvaia, Amber Malhotra, Himanshu Acharya, Komal Shah, Jeevraj Rajavat
Background: The prevalence of diabetes mellitus in patients requiring coronary artery bypass grafting (CABG) is noticeably high (20%-30%). These patients have inferior perioperative outcome, reduced long-term survival, and high risk of recurrent episodes of angina. To improve perioperative outcome surgical unit defined satisfactory glycemic control is desired during this period. Hence, the aim of our study is to compare the efficacy of glargine insulin combination with continuous human insulin infusion for perioperative glycemic control in patients with diabetes undergoing CABG...
April 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29651388/the-effect-of-oral-propranolol-versus-oral-corticosteroids-in-management-of-pediatric-hemangiomas
#9
Adil Ali, Umme Aiman, Mohd Azam Haseen, Mohd Altaf Mir, Imran Ghani, Ragya Bharadwaj, Mohd Yaseen
BACKGROUND: Hemangiomas are the most common benign tumors of infancy. This study evaluated the efficacy of oral propranolol comparing to oral steroids in management of pediatric hemangiomas. METHODS: In North India from January 2012 to January 2015, sixty children <6 years old with superficial hemangiomas were divided into 2 groups; oral propranolol vs. oral prednisolone. All participants were assessed for electrocardiogram, heart rate, blood pressure and sugar and initial therapy was started using 1 mg/kg and in absence of adverse effects, 2 mg/kg was administered after 2 weeks...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29651145/multicomponent-reactions-provide-key-molecules-for-secret-communication
#10
Andreas C Boukis, Kevin Reiter, Maximiliane Frölich, Dennis Hofheinz, Michael A R Meier
A convenient and inherently more secure communication channel for encoding messages via specifically designed molecular keys is introduced by combining advanced encryption standard cryptography with molecular steganography. The necessary molecular keys require large structural diversity, thus suggesting the application of multicomponent reactions. Herein, the Ugi four-component reaction of perfluorinated acids is utilized to establish an exemplary database consisting of 130 commercially available components...
April 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29628663/distribution-of-laboratory-parameters-in-trauma-population
#11
Prashant Bhandarkar, Ranabir Pal, Ashok Munivenkatappa, Nobhojit Roy, Vineet Kumar, Amit Agrawal
Background: Biochemical laboratory investigations help plan optimum management and communication in short- as well as long-term outcome to trauma victims. Objective: To assess the status of real-time values of biochemical laboratory investigations of different trauma patients and their association with overall mortality. Materials and Methods: Data based on prospective, observational registry of "Towards Improved Trauma Care Outcomes" (TITCO) from four Indian city hospitals...
January 2018: Journal of Emergencies, Trauma, and Shock
https://www.readbyqxmd.com/read/29627992/beneficial-effect-of-the-sglt2-inhibitor-empagliflozin-on-glucose-homeostasis-and-cardiovascular-parameters-in-the-cohen-rosenthal-diabetic-hypertensive-crdh-rat
#12
Firas Younis, Jonathan Leor, Zaid Abassi, Natalie Landa, Lea Rath, Kenneth Hollander, Nili Naftali-Shani, Talma Rosenthal
The effectiveness of empagliflozin (EMPA), a sodium glucose cotransporter type 2 inhibitor, on the kidney, pancreas, and heart was investigated in the Cohen Rosenthal diabetic hypertensive rat model (CRDH rat). Six-week-old CRDH male rats were fed a sugar diet (SD) and treated with the compound EMPA (group Drug/SD) or respective comparator with vehicle (group Veh/SD). A control group was fed a regular diet without treatment (group Veh/P). Preventive treatment with EMPA was measured during 4 months of follow-up...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29624857/impact-of-wedelolactone-in-the-anti-glycation-and-anti-diabetic-activity-in-experimental-diabetic-animals
#13
Uzma Shahab, Mohammad Faisal, Abdulrahman A Alatar, Saheem Ahmad
The glycation reaction is the addition of free carbonyl group of reducing sugar to the free amino groups of proteins, lipoproteins and nucleic acids which results in the formation of an Amadori product which may ultimately lead to the generation of advanced glycation products (AGEs). The impact of AGEs on proteins consequently generates free radicals, "a key player" for the pathogenesis of diabetes mellitus. Gel electrophoresis was carried out to see the visual changes taking place as a result of the glycation reaction...
April 6, 2018: IUBMB Life
https://www.readbyqxmd.com/read/29622188/inhibitory-activity-of-minor-phlorotannins-from-ecklonia-cava-on-%C3%AE-glucosidase
#14
Sae Rom Park, Jang Hoon Kim, Hae Dong Jang, Seo Young Yang, Young Ho Kim
α-Glucosidase is an enzyme that plays a key role in raising blood sugar level and is considered a good target for developing drugs to treat type 2 diabetes. This study was performed to evaluate the inhibition of the catalytic reaction of α-glucosidase by minor phlorotannin derivatives (1-5) from Ecklonia cava. These derivatives demonstrated inhibitory activity, with IC50 values ranging from 2.3 ± 0.1 to 59.8 ± 0.8 μM. Among the phlorotannins identified, compounds 2 and 3-5 were revealed to be non-competitive and competitive inhibitors, respectively...
August 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29622058/association-of-health-literacy-with-type-2-diabetes-mellitus-self-management-and-clinical-outcomes-within-the-primary-care-setting-of-iran
#15
Marzieh Niknami, Ali Mirbalouchzehi, Iraj Zareban, Elahibakhsh Kalkalinia, Gasem Rikhtgarha, Hassan Hosseinzadeh
This study explores the potential association of health literacy with type 2 diabetes mellitus (T2DM) self-management and clinical outcomes in the primary care setting of Iran. A total of 347 T2DM patients, mostly female (52.4%), 50 years old or younger (63.1%), unemployed (53.6%) and rural residents (55.6%) participated in this study. Most of the respondents had type 2 diabetes mellitus (T2DM) for 2-5 years (63.1%) and did not receive any T2DM education (52.2%). Approximately 19.0% were hospitalised due to uncontrolled T2DM...
April 6, 2018: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/29619625/effects-of-plasma-glycosyltransferase-on-the-abo-h-blood-group-antigens-of-human-von-willebrand-factor
#16
Taiki Kano, Kazunao Kondo, Jiharu Hamako, Fumio Matsushita, Kazuya Sakai, Taei Matsui
Von Willebrand factor (VWF) is one of the plasma protein carrying ABO(H) blood group antigens, but the combining process of these antigens is not clear. In the present study, we examined whether plasma glycosyltransferase affects the blood group antigens on VWF. VWF expressing H-antigen (H-VWF) from blood group O and bovine serum albumin conjugated with H-antigen (H-BSA) were incubated with recombinant α1-3-N-acetylgalactosaminyltransferase (rA-transferase) and A-plasma with or without an additional UDP-GalNAc...
April 4, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29618887/comparison-of-ropivacaine-0-75-and-lignocaine-2-with-1-200-000-adrenaline-in-dental-extractions-single-blind-clinical-trial
#17
Vishal Bansal, Deval Kumar, Apoorva Mowar, Avi Bansal
Introduction: The aim of this study was to evaluate the efficacy, safety and clinical acceptability of the local anaesthetic agent ropivacaine 0.75 % in comparison with lignocaine 2 % with adrenaline 1:200,000 in minor oral surgical procedures. Methods: Forty-seven patients, who required bilateral extractions in a single arch, were included in this study. One hundred and sixty-six extractions were performed and all the patients were administered nerve blocks/infiltration...
June 2018: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/29617350/co-ingestion-of-rice-bran-soymilk-or-plain-soymilk-with-white-bread-effects-on-the-glycemic-and-insulinemic-response
#18
Stefan Gerardus Camps, Joseph Lim, Atsushi Ishikado, Yumi Inaba, Makoto Suwa, Motonobu Matsumoto, Christiani Jeyakumar Henry
The regular consumption of soy products is associated with inverse incidence of type 2 diabetes, and there has been an increasing interest in the glycemia reducing potential of rice bran and its components. In this study, we investigated whether consuming soymilk with the addition of rice bran (fiber) can reduce the glycemic response of a carbohydrate meal. Seventeen healthy Asian men (BMI: 18.5-29 kg/m²) participated in this randomized crossover trial. On four occasions, they consumed white bread (two times) and white bread with two different soymilks differing in protein and rice bran content...
April 4, 2018: Nutrients
https://www.readbyqxmd.com/read/29615832/prevalence-and-risk-factors-of-diabetic-retinopathy-among-an-elderly-population-with-diabetes-in-nepal-the-bhaktapur-retina-study
#19
Raba Thapa, Shankha N Twyana, Govinda Paudyal, Shankar Khanal, Ruth van Nispen, Stevie Tan, Suman S Thapa, Ghmb van Rens
Aim: Diabetic retinopathy (DR) is an emerging cause of blindness in developing countries. This study aimed to explore the prevalence and risk factors of DR in an elderly population in Nepal. Subjects and methods: This is a population-based, cross-sectional study. A total of 1860 subjects at the age 60 years and above participated (response rate 88.6%). A detailed history was obtained, presenting and best-corrected visual acuity were measured, and anterior segment and posterior segment examinations were carried out...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29615674/acute-metabolic-actions-of-the-major-polyphenols-in-chamomile-an-in-vitro-mechanistic-study-on-their-potential-to-attenuate-postprandial-hyperglycaemia
#20
Jose A Villa-Rodriguez, Asimina Kerimi, Laszlo Abranko, Sarka Tumova, Lauren Ford, Richard S Blackburn, Christopher Rayner, Gary Williamson
Transient hyperglycaemia is a risk factor for type 2 diabetes and endothelial dysfunction, especially in subjects with impaired glucose tolerance. Nutritional interventions and strategies for controlling postprandial overshoot of blood sugars are considered key in preventing progress to the disease state. We have identified apigenin-7-O-glucoside, apigenin, and (Z) and (E)-2-hydroxy-4-methoxycinnamic acid glucosides as the active (poly)phenols in Chamomile (Matricaria recutita) able to modulate carbohydrate digestion and absorption in vitro as assessed by inhibition of α-amylase and maltase activities...
April 3, 2018: Scientific Reports
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