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https://www.readbyqxmd.com/read/29772997/noncoding-rnas-ncrna-in-hepato-cancer-a-review
#1
Xiujuan Sun, Anshoo Malhotra
Hepatocellular carcinoma (HCC) has emerged as a prominent cancer in both developing and developed countries. Due to the increasing burden of HCC patients, massive resources are expended in their management. Furthermore, there is an urgent need to identify new molecular players that could be targeted to halt cancer development in the early phases. Noncoding RNAs (ncRNAs), which were previously thought to lack value, have the potential to play a pivotal role in the present era of personalized and translational research...
2018: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29768466/core-non-coding-rnas-of-piscirickettsia-salmonis
#2
Cristopher Segovia, Raul Arias-Carrasco, Alejandro J Yañez, Vinicius Maracaja-Coutinho, Javier Santander
Piscirickettsia salmonis, a fastidious Gram-negative intracellular facultative bacterium, is the causative agent o Piscirickettsiosis. P. salmonis has broad host range with a nearly worldwide distribution, causing significant mortality. The molecular regulatory mechanisms of P. salmonis pathogenesis are relatively unknown, mainly due to its difficult in vitro culture and genomic differences between genogroups. Bacterial non-coding RNAs (ncRNAs) are important post-transcriptional regulators of bacterial physiology and virulence that are predominantly transcribed from intergenic regions (trans-acting) or antisense strand of open reading frames (cis-acting)...
2018: PloS One
https://www.readbyqxmd.com/read/29760792/the-emerging-role-of-circular-rnas-in-hepatocellular-carcinoma
#3
REVIEW
Li-Peng Qiu, Yi-Hang Wu, Xiao-Feng Yu, Qi Tang, Liang Chen, Ke-Ping Chen
Hepatocellular carcinoma (HCC) ranks the third leading cause of cancer death in the world and has a notably low survival rate. Circular RNAs (circRNAs) are newly classed non-coding RNA (ncRNA) members that are capable of regulating gene expression at transcription or post-transcription levels. Recent studies demonstrate that some circRNAs are differentially expressed in HCC, and the deregulation of these circRNAs is associated with the clinical pathological and prognostic significance. They also play essential roles in HCC progression, and contribute to cell proliferation, migration, invasion and metastasis by targeting different microRNAs (miRNAs) and protein-coding genes...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29751065/a-3-utr-derived-non-coding-rna-ribs-increases-expression-of-cfa-and-promotes-biofilm-formation-of-salmonella-enterica-serovar-typhi
#4
Xin Zhao, Rui Liu, Hao Tang, George Osei-Adjei, Shungao Xu, Ying Zhang, Xinxiang Huang
Bacterial non-coding RNAs (ncRNAs) are widely studied and found to play important roles in regulating various cellular processes. Recently, many ncRNAs have been discovered to be transcribed or processed from 3' untranslated regions (3' UTRs). Here we reported a novel 3' UTR-derived ncRNA, RibS, which could influence biofilm formation of Salmonella enterica serovar Typhi (S. Typhi). RibS was confirmed to be a ∼700 nt processed product produced by RNase III-catalyzed cleavage from the 3' UTR of riboflavin synthase subunit alpha mRNA, RibE...
May 8, 2018: Research in Microbiology
https://www.readbyqxmd.com/read/29748184/dual-suppressive-effect-of-microrna-34a-on-the-foxm1-eef2-kinase-axis-regulates-triple-negative-breast-cancer-growth-and-invasion
#5
Recep Bayraktar, Cristina Ivan, Emine Bayraktar, Pinar Kanlikilicer, Nashwa Kabil, Nermin Kahraman, Hamada Ahmed Mokhlis, Didem Karakas, Cristian Rodriguez-Aguayo, Ahmet Arslan, Jianting Sheng, Stephen Tc Wong, Gabriel Lopez-Berestein, George A Calin, Bulent Ozpolat
Purpose - Recent studies indicated that dysregulation of non-coding RNAs (ncRNAs) such as microRNAs (miRNAs) is involved in pathogenesis of various human cancers. However, the molecular mechanisms underlying miR-34a are not fully understood in triple-negative breast cancer (TNBC). Experimental Design- We performed  in vitro  functional assays on TNBC cell lines to investigate the role of miR-34a in FOXM1/eEF2K signaling axis. TNBC tumor xenograft models were used for in vivo therapeutic delivery of miR-34a...
May 10, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29743276/non-coding-rna-in-cystic-fibrosis
#6
REVIEW
Arlene M A Glasgow, Chiara De Santi, Catherine M Greene
Non-coding RNAs (ncRNAs) are an abundant class of RNAs that include small ncRNAs, long non-coding RNAs (lncRNA) and pseudogenes. The human ncRNA atlas includes thousands of these specialised RNA molecules that are further subcategorised based on their size or function. Two of the more well-known and widely studied ncRNA species are microRNAs (miRNAs) and lncRNAs. These are regulatory RNAs and their altered expression has been implicated in the pathogenesis of a variety of human diseases. Failure to express a functional cystic fibrosis (CF) transmembrane receptor (CFTR) chloride ion channel in epithelial cells underpins CF...
May 9, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29738839/identification-of-micrornas-and-long-non-coding-rnas-involved-in-fatty-acid-biosynthesis-in-tree-peony-seeds
#7
Dan-Dan Yin, Shan-Shan Li, Qing-Yan Shu, Zhao-Yu Gu, Qian Wu, Cheng-Yong Feng, Wen-Zhong Xu, Liang-Sheng Wang
MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) act as important molecular regulators in a wide range of biological processes during plant development and seed formation, including oil production. Tree peony seeds contain >90% unsaturated fatty acids (UFAs) and high proportions of α-linolenic acid (ALA, > 40%). To dissect the non-coding RNAs (ncRNAs) pathway involved in fatty acids synthesis in tree peony seeds, we construct six small RNA libraries and six transcriptome libraries from developing seeds of two cultivars (J and S) containing different content of fatty acid compositions...
May 5, 2018: Gene
https://www.readbyqxmd.com/read/29732173/alterations-in-sperm-dna-methylation-non-coding-rna-expression-and-histone-retention-mediate-vinclozolin-induced-epigenetic-transgenerational-inheritance-of-disease
#8
Millissia Ben Maamar, Ingrid Sadler-Riggleman, Daniel Beck, Margaux McBirney, Eric Nilsson, Rachel Klukovich, Yeming Xie, Chong Tang, Wei Yan, Michael K Skinner
Epigenetic transgenerational inheritance of disease and phenotypic variation can be induced by several toxicants, such as vinclozolin. This phenomenon can involve DNA methylation, non-coding RNA (ncRNA) and histone retention, and/or modification in the germline (e.g. sperm). These different epigenetic marks are called epimutations and can transmit in part the transgenerational phenotypes. This study was designed to investigate the vinclozolin-induced concurrent alterations of a number of different epigenetic factors, including DNA methylation, ncRNA, and histone retention in rat sperm...
April 2018: Environmental Epigenetics
https://www.readbyqxmd.com/read/29722561/the-role-of-non-coding-rnas-in-regulating-epithelial-responses-in-copd
#9
Yifan Chen, Paul S Thomas, Rakesh K Kumar, Cristan Herbert
Chronic obstructive pulmonary disease (COPD), one of the leading causes of death in the world, is a chronic inflammatory disease of the airways usually caused by long-term exposure to inhaled irritants. Airway epithelial cells (AECs) play a key role in initializing COPD and driving the exacerbation of this disease through the release of various cytokines. This AEC-derived cytokine response is tightly regulated possibly through the regulatory effects of non-coding RNAs (ncRNAs). Although the importance of ncRNAs in pulmonary diseases has been increasingly realized, little is known about the role of ncRNA in the regulation of inflammatory responses in COPD...
May 3, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29709557/structural-insights-into-n-6-methyladenosine-m-6-a-modification-in-the-transcriptome
#10
REVIEW
Jinbo Huang, Ping Yin
More than 100 types of chemical modifications in RNA have been well documented. Recently, several modifications, such as N6 -methyladenosine (m6 A), have been detected in mRNA, opening the window into the realm of epitranscriptomics. The m6 A modification is the most abundant modification in mRNA and non-coding RNA (ncRNA). At the molecular level, m6 A affects almost all aspects of mRNA metabolism, including splicing, translation, and stability, as well as microRNA (miRNA) maturation, playing essential roles in a range of cellular processes...
April 27, 2018: Genomics, Proteomics & Bioinformatics
https://www.readbyqxmd.com/read/29706607/identifying-circrna-associated-cerna-networks-in-the-hippocampus-of-a%C3%AE-1-42-induced-alzheimer-s-disease-like-rats-using-microarray-analysis
#11
Zhe Wang, Panpan Xu, Biyue Chen, Zheyu Zhang, Chunhu Zhang, Qiong Zhan, Siqi Huang, Zi-An Xia, Weijun Peng
Alzheimer's disease (AD) is the most common form of dementia worldwide. Accumulating evidence indicates that non-coding RNAs are strongly implicated in AD-associated pathophysiology. However, the role of these ncRNAs remains largely unknown. In the present study, we used microarray analysis technology to characterize the expression patterns of circular RNAs (circRNAs), microRNAs (miRNAs), and mRNAs in hippocampal tissue from Aβ1-42 -induced AD model rats, to integrate interaction data and thus provide novel insights into the mechanisms underlying AD...
April 27, 2018: Aging
https://www.readbyqxmd.com/read/29698635/exosomal-mir-21a-5p-mediates-cardioprotection-by-mesenchymal-stem-cells
#12
Kristin M Luther, Lauren Haar, Myc McGuinness, Yang Wang, Tom Lynch, Anh Phan, Yang Song, Zilong Shen, George Gardner, Gina Kuffel, Xiaoping Ren, Michael J Zilliox, W Keith Jones
Though experimental, stem cell transplantation has the potential to improve the condition of the heart after myocardial infarction. It does so by reducing infarct size and inducing repair of heart muscle and its blood supply. Mesenchymal stem cells (MSC) have been found to be effective in pre-clinical animal models and clinical trials, but the mechanisms by which they induce cardioprotection and repair are still not fully understood. Small extracellular vesicles known as exosomes are now recognized to be key mediators of beneficial MSC paracrine effects, and the concept that they transfer miRNA to change gene expression in recipient cells is of current therapeutic interest...
April 23, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29697794/non-coding-rnas-in-endometriosis-a-narrative-review
#13
Kavita Panir, John E Schjenken, Sarah A Robertson, M Louise Hull
BACKGROUND: Endometriosis is a benign gynaecological disorder, which affects 10% of reproductive-aged women and is characterized by endometrial cells from the lining of the uterus being found outside the uterine cavity. However, the pathophysiological mechanisms causing the development of this heterogeneous disease remain enigmatic, and a lack of effective biomarkers necessitates surgical intervention for diagnosis. There is international recognition that accurate non-invasive diagnostic tests and more effective therapies are urgently needed...
April 25, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29692219/uncovering-novel-landscape-of-cardiovascular-diseases-and-therapeutic-targets-for-cardioprotection-via-long-noncoding-rna-mirna-mrna-axes
#14
Liang He, Yan Chen, Shuqing Hao, Jinqiao Qian
Protein coding sequences account for around 3% of the human genome, the rest are noncoding RNA (ncRNA) including long ncRNA (lncRNA) and miRNA. Accumulating evidence indicates that lncRNAs and miRNAs are candidate biomarkers for diagnosis, prognosis and therapy of cardiovascular diseases. The lncRNAs act as sponge-like effects on numerous miRNAs, subsequently regulating miRNAs and their targets, mRNA functions. The role of lncRNA-miRNA-mRNA axis in pathogenesis of cardiovascular diseases has been recently reported and highlighted...
April 25, 2018: Epigenomics
https://www.readbyqxmd.com/read/29691407/long-ncrna-a-rod-activates-its-target-gene-dkk1-at-its-release-from-chromatin
#15
Evgenia Ntini, Annita Louloupi, Julia Liz, Jose M Muino, Annalisa Marsico, Ulf Andersson Vang Ørom
Long ncRNAs are often enriched in the nucleus and at chromatin, but whether their dissociation from chromatin is important for their role in transcription regulation is unclear. Here, we group long ncRNAs using epigenetic marks, expression and strength of chromosomal interactions; we find that long ncRNAs transcribed from loci engaged in strong long-range chromosomal interactions are less abundant at chromatin, suggesting the release from chromatin as a crucial functional aspect of long ncRNAs in transcription regulation of their target genes...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29691221/small-ncrna-seq-results-of-human-tissues-variations-depending-on-sample-integrity
#16
Nicole Ludwig, Tobias Fehlmann, Valentina Galata, Andre Franke, Christina Backes, Eckart Meese, Andreas Keller
BACKGROUND: Although mature miRNAs are relatively stable in vivo, RNA degradation can have a substantial influence on small noncoding RNA (sncRNA) profiles. METHODS: Using different tissue storage conditions and RNA isolation procedures, we analyzed the integrity and quality of RNA isolates from human lung and heart tissues. We sequenced a total of 64 RNA samples and quantified the effect of RNA degradation, DNA contamination, and other confounding factors on the sncRNA-seq data...
April 24, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29688487/circulating-non-coding-rnas-in-biomarker-guided-cardiovascular-therapy-a-novel-tool-for-personalized-medicine
#17
David de Gonzalo-Calvo, Angela Vea, Christian Bär, Jan Fiedler, Liam S Couch, Carlos Brotons, Vicenta Llorente-Cortes, Thomas Thum
Current clinical guidelines emphasize the unmet need for technological innovations to guide physician decision-making and to transit from conventional care to personalized cardiovascular medicine. Biomarker-guided cardiovascular therapy represents an interesting approach to inform tailored treatment selection and monitor ongoing efficacy. However, results from previous publications cast some doubts about the clinical applicability of biomarkers to direct individualized treatment. In recent years, the non-coding human transcriptome has emerged as a new opportunity for the development of novel therapeutic strategies and biomarker discovery...
April 24, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29686135/7sl-rna-in-vertebrate-red-blood-cells
#18
Gaëlle J S Talhouarne, Joseph G Gall
We report that 7SL, the RNA component of the signal recognition particle (SRP), is an abundant ncRNA in mature red blood cells (RBCs) of human, mouse, and the frog Xenopus. 7SL RNA in RBCs is not associated with the canonical proteins of the SRP. Instead, it co-immunoprecipitates from a lysate of RBCs with a number of membrane-binding proteins. Human and mouse RBCs also contain a previously undescribed 68 nt RNA, sRN7SL, derived from the "S domain" of 7SL RNA. We discuss the possibility that 7SL RNA is selectively protected from nucleases by association with the RBC membrane...
April 23, 2018: RNA
https://www.readbyqxmd.com/read/29671405/ncrna-disease-association-prediction-based-on-sequence-information-and-tripartite-network
#19
Takuya Mori, Hayliang Ngouv, Morihiro Hayashida, Tatsuya Akutsu, Jose C Nacher
BACKGROUND: Current technology has demonstrated that mutation and deregulation of non-coding RNAs (ncRNAs) are associated with diverse human diseases and important biological processes. Therefore, developing a novel computational method for predicting potential ncRNA-disease associations could benefit pathologists in understanding the correlation between ncRNAs and disease diagnosis, treatment, and prevention. However, only a few studies have investigated these associations in pathogenesis...
April 11, 2018: BMC Systems Biology
https://www.readbyqxmd.com/read/29669292/parn-and-toe1-constitute-a-3-end-maturation-module-for-nuclear-non-coding-rnas
#20
Ahyeon Son, Jong-Eun Park, V Narry Kim
Poly(A)-specific ribonuclease (PARN) and target of EGR1 protein 1 (TOE1) are nuclear granule-associated deadenylases, whose mutations are linked to multiple human diseases. Here, we applied mTAIL-seq and RNA sequencing (RNA-seq) to systematically identify the substrates of PARN and TOE1 and elucidate their molecular functions. We found that PARN and TOE1 do not modulate the length of mRNA poly(A) tails. Rather, they promote the maturation of nuclear small non-coding RNAs (ncRNAs). PARN and TOE1 act redundantly on some ncRNAs, most prominently small Cajal body-specific RNAs (scaRNAs)...
April 17, 2018: Cell Reports
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