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fever and antipyretics in children

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https://www.readbyqxmd.com/read/27872357/antipyretic-efficacy-and-safety-of-ibuprofen-versus-acetaminophen-suspension-in-febrile-children-results-of-2-randomized-double-blind-single-dose-studies
#1
Shyamalie Jayawardena, David Kellstein
Two blinded single-dose studies randomized children 6 months to 11 years old with fever to receive ibuprofen (IBU) pediatric suspension 7.5 mg/kg or acetaminophen (APAP) suspension 10 to 15 mg/kg. The primary efficacy parameter was time-weighted sum of temperature differences (TWSTD) from baseline through 8 hours for each study. Secondary end points included TWSTD from baseline through 6 hours, time to onset and duration of temperature control, and proportion with temperature control. Studies were pooled for post hoc analyses of efficacy and adverse event end points...
November 20, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27825318/prevalence-of-malaria-typhoid-toxoplasmosis-and-rubella-among-febrile-children-in-cameroon
#2
Olivia A Achonduh-Atijegbe, Kenji O Mfuh, Aristid H E Mbange, Jean P Chedjou, Diane W Taylor, Vivek R Nerurkar, Wilfred F Mbacham, Rose Leke
BACKGROUND: The current roll-out of rapid diagnostic tests (RDTs) in many endemic countries has resulted in the reporting of fewer cases of malaria-attributed illnesses. However, lack of knowledge of the prevalence of other febrile illnesses and affordable diagnostic tests means that febrile patients are not managed optimally. This study assessed the prevalence of commonly treatable or preventable febrile illnesses in children between 6 months and 15 years using rapid diagnostic tests at the point-of-care...
November 8, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27810155/2016-update-of-the-italian-pediatric-society-guidelines-for-management-of-fever-in-children
#3
Elena Chiappini, Elisabetta Venturini, Giulia Remaschi, Nicola Principi, Riccardo Longhi, Pier-Angelo Tovo, Paolo Becherucci, Francesca Bonsignori, Susanna Esposito, Filippo Festini, Luisa Galli, Bice Lucchesi, Alessandro Mugelli, Gian Luigi Marseglia, Maurizio de Martino
OBJECTIVE: To review new scientific evidence to update the Italian guidelines for managing fever in children as drafted by the panel of the Italian Pediatric Society. STUDY DESIGN: Relevant publications in English and Italian were identified through search of MEDLINE and the Cochrane Database of Systematic Reviews from May 2012 to November 2015. RESULTS: Previous recommendations are substantially reaffirmed. Antipyretics should be administered with the purpose to control the child's discomfort...
October 31, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27798399/parental-approach-to-the-prevention-and-management-of-fever-and-pain-following-childhood-immunizations-a-survey-study
#4
Ezzeldin Saleh, Geeta K Swamy, M Anthony Moody, Emmanuel B Walter
Antipyretic analgesics are commonly used to prevent and treat adverse events following immunizations. Current practice discourages routine use due to possible blunting of vaccine immune responses. We surveyed 150 parents/caregivers of recently vaccinated 6- and 15-month-old children to determine the prevalence of and beliefs regarding antipyretic analgesics use around vaccinations. 11% used them prophylactically, before vaccination. Use in the first 48 hours after vaccination was 64%, primarily to prevent and/or treat fever and pain...
October 23, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27781110/why-fever-phobia-is-still-common
#5
Suzan Gunduz, Esma Usak, Tulin Koksal, Metin Canbal
BACKGROUND: Fever is a reliable sign of illness, but it also evokes fear and anxiety. It is not the fever itself but the fear of possible complications and accompanying symptoms that is important for pediatricians and parents. OBJECTIVES: We aimed to investigate maternal understanding of fever, its potential consequences, and impacts on the treatment of children. PATIENTS AND METHODS: A questionnaire was use to explore the attitudes, knowledge, and practices of mothers of 861 children brought to four medical centers in different regions of Turkey in 2012, with fever being the chief complaint...
August 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27733747/national-modulators-of-symptomatic-fever-management-in-children-comparative-analysis-of-survey-data
#6
Sebastiano A Lava, Maristella Santi, Gregorio P Milani, Mario G Bianchetti, Giacomo D Simonetti
BACKGROUND: In symptomatic fever management of children, cultural differences have been detected. We aimed at investigating the presence of national modulators of symptomatic fever management. METHODS: We analyzed the data collected in the context of the Swiss national survey on symptomatic fever management in children and of an adapted version of that survey performed in Lombardy (Northern Italy). RESULTS: Ibuprofen (p<0.001) and an alternation regimen with 2 drugs (p<0...
October 12, 2016: Minerva Pediatrica
https://www.readbyqxmd.com/read/27642433/-asymptomatic-parasitemia-in-under-five-school-age-children-and-households-self-medication-lubumbashi-democratic-republic-of-congo
#7
Sompwe Eric Mukomena, Cilundika Mulenga Philipe, Mashinda Kulimba Désiré, Lutumba Tshindele Pascal, Mapatano Mala Ali, Luboya Numbi Oscar
INTRODUCTION: Long neglected, asymptomatic malaria is currently recognized as a potential threat and obstacle to malaria control. In DR Congo, the prevalence of this parasite is poorly documented. This study aims to determine the prevalence of asymptomatic parasitaemia in children less than 5 years of age as well as in those aged over five years for what concerns ongoing mass control interventions (LLINs). METHODS: This is a cross-sectional study conducted among school age children, children less than 5 years of age living in the household of Lubumbashi...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27458064/ibuprofen-in-paediatrics-pharmacology-prescribing-and-controversies
#8
Camilla Moriarty, Will Carroll
Ibuprofen, a propionic acid derivative, is a non-steroidal anti-inflammatory drug. The oral formulation is widely used in paediatric practice and after paracetamol it is one of the most common drugs prescribed for children in hospital. The treatment of fever with antipyretics such as ibuprofen is controversial as fever is the normal response of the body to infection and unless the child becomes distressed or symptomatic, fever alone should not be routinely treated. Combined treatment with paracetamol and ibuprofen is commonly undertaken but almost certainly is not helpful...
December 2016: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/27401677/parental-knowledge-attitudes-and-beliefs-regarding-fever-in-children-an-interview-study
#9
Maria Kelly, Laura J Sahm, Frances Shiely, Ronan O'Sullivan, Aoife McGillicuddy, Suzanne McCarthy
BACKGROUND: Fever is one of the most common childhood symptoms. It causes significant worry and concern for parents. Every year there are numerous cases of over- and under-dosing with antipyretics. Caregivers seek reassurance from a variety of sources including healthcare practitioners. The aim of this study was to describe parental knowledge, attitudes and beliefs regarding management of childhood fever in children aged 5 years and under. METHOD: Semi-structured interviews were conducted with 23 parents at six ante-natal clinics in the south west of Ireland during March and April 2015...
July 11, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27315082/drivers-for-inappropriate-fever-management-in-children-a-systematic-review
#10
M Kelly, S McCarthy, R O'Sullivan, F Shiely, P Larkin, M Brenner, L J Sahm
Background Fever is one of the most common childhood symptoms and accounts for numerous consultations with healthcare practitioners. It causes much anxiety amongst parents as many struggle with managing a feverish child and find it difficult to assess fever severity. Over- and under-dosing of antipyretics has been reported. Aim of the review The aim of this review was to synthesise qualitative and quantitative evidence on the knowledge, attitudes and beliefs of parents regarding fever and febrile illness in children...
August 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27164121/pediatric-epidemic-of-salmonella-enterica-serovar-typhimurium-in-the-area-of-l-aquila-italy-four-years-after-a-catastrophic-earthquake
#11
Giovanni Nigro, Gabriella Bottone, Daniela Maiorani, Fabiana Trombatore, Silvana Falasca, Gianfranco Bruno
BACKGROUND: A Salmonella enterica epidemic occurred in children of the area of L'Aquila (Central Italy, Abruzzo region) between June 2013 and October 2014, four years after the catastrophic earthquake of 6 April 2009. METHODS: Clinical and laboratory data were collected from hospitalized and ambulatory children. Routine investigations for Salmonella infection were carried out on numerous alimentary matrices of animal origin and sampling sources for drinking water of the L'Aquila district, including pickup points of the two main aqueducts...
2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27118212/pharmacokinetic-properties-of-intramuscular-versus-oral-syrup-paracetamol-in-plasmodium-falciparum-malaria
#12
Thanaporn Wattanakul, Pramote Teerapong, Katherine Plewes, Paul N Newton, Wirongrong Chierakul, Kamolrat Silamut, Kesinee Chotivanich, Ronnatrai Ruengweerayut, Nicholas J White, Arjen M Dondorp, Joel Tarning
BACKGROUND: Fever is an inherent symptom of malaria in both adults and children. Paracetamol (acetaminophen) is the recommended antipyretic as it is inexpensive, widely available and has a good safety profile, but patients may not be able to take the oral drug reliably. A comparison between the pharmacokinetics of oral syrup and intramuscular paracetamol given to patients with acute falciparum malaria and high body temperature was performed. METHODS: A randomized, open-label, two-treatment, crossover, pharmacokinetic study of paracetamol dosed orally and intramuscularly was conducted...
2016: Malaria Journal
https://www.readbyqxmd.com/read/26920747/acetaminophen-administration-in-pediatric-age-an-observational-prospective-cross-sectional-study
#13
Riccardo Lubrano, Sara Paoli, Marco Bonci, Luigi Di Ruzza, Corrado Cecchetti, Raffaele Falsaperla, Piero Pavone, Nassim Matin, Giovanna Vitaliti, Isotta Gentile
BACKGROUND: Parents often do not consider fever as an important physiological response and mechanism of defense against infections that leads to inappropriate use of antipyretics and potentially dangerous side effects. This study is designed to evaluate the appropriateness of antipyretics dosages generally administered to children with fever, and to identify factors that may influence dosage accuracy. RESULTS: In this cross-sectional study we analyzed the clinical records of 1397 children aged >1 month and < 16 years, requiring a primary care (ambulatory) outpatient visit due to fever...
February 26, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/26899521/appendicitis-in-the-infant-population-a-case-report-and-review-of-a-four-month-old-with-appendicitis
#14
Lisa C Goldberg, Jessica Prior, Dale Woolridge
BACKGROUND: Appendicitis is uncommon in children <6 months old, with few observational studies reporting cases of children younger than 5 years old with the diagnosis. The classic periumbilical pain that migrates to the right lower quadrant, followed by the onset of fever and vomiting, is present in approximately 40% of pediatric patients under 12 years of age with appendicitis. CASE REPORT: A 4-month-old girl presented to the Emergency Department (ED) with acute onset of grunting, pallor, fussiness, emesis, and diarrhea...
May 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26889398/rectal-diclofenac-versus-rectal-paracetamol-comparison-of-antipyretic-effectiveness-in-children
#15
Mohammad Reza Sharif, Mostafa Haji Rezaei, Marzieh Aalinezhad, Golbahareh Sarami, Masoud Rangraz
BACKGROUND: Fever is the most common complaint in pediatric medicine and its treatment is recommended in some situations. Paracetamol is the most common antipyretic drug, which has serious side effects such as toxicity along with its positive effects. Diclofenac is one of the strongest non-steroidal anti-inflammatory (NSAID) drugs, which has received little attention as an antipyretic drug. OBJECTIVES: This study was designed to compare the antipyretic effectiveness of the rectal form of Paracetamol and Diclofenac...
January 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/26539405/pilot-study-of-the-use-of-yin-qiao-san-in-children-with-conventional-antipyretic-hypersensitivity
#16
Woei Kang Liew, Wenyin Loh, Wen Chin Chiang, Anne Goh, Oh Moh Chay, Mona Iancovici Kidon
BACKGROUND: Children with a diagnosis of cross-reactive hypersensitivity to both paracetamol and nonsteroidal anti-inflammatory drugs are limited in their choice of antipyretics. OBJECTIVE: The aim of this pilot study is to evaluate the feasibility of using a Chinese proprietary medicine, Yin Qiao San (YQS), for fever relief. METHODS: A single centre, open label, prospective clinical trial exploring the tolerability and feasibility of using YQS for fever relief in children who are unable to use conventional antipyretic medications...
October 2015: Asia Pacific Allergy
https://www.readbyqxmd.com/read/26514056/managing-the-child-with-a-fever
#17
REVIEW
Rosie Hague
Most illnesses associated with fever are self-limiting and children recover with no specific treatment. However, fever can also be the presenting feature of serious illness, which may be life threatening if not diagnosed and treated appropriately. It is important to establish whether the temperature has been measured and, if so, how. The height of the temperature should be recorded, and always enquire what device has been used, as a reading from a forehead thermometer may not be accurate. While many families will use a thermometer the impression of the child being hot to touch without formal measurement should still be taken seriously...
July 2015: Practitioner
https://www.readbyqxmd.com/read/26482129/fever-phobia-a-comparison-survey-between-caregivers-in-the-inpatient-ward-and-caregivers-at-the-outpatient-department-in-a-children-s-hospital-in-china
#18
COMPARATIVE STUDY
Lili Dong, Jiahui Jin, Yili Lu, Lili Jiang, Xiaoou Shan
BACKGROUND: Fever in children is one of the most common clinical symptoms and a chief complaint and a main reason that caregivers took the children to the outpatient service or admitted to hospital. Studies have found that the majority of parents surveyed at a hospital pediatric clinic held unrealistic and unwarranted concerns about fevers, first termed as 'fever phobia' by Schmitt in 1980. In the present study, we explore whether 'fever phobia' exists in Chinese caregivers and investigate whether such phobia is alleviated when admitted to hospital after propaganda of fever related knowledge by doctors and nurses...
2015: BMC Pediatrics
https://www.readbyqxmd.com/read/26387247/management-of-acute-childhood-fevers
#19
Polly Teuten, Siba Prosad Paul, Paul Anthony Heaton
Feverish illnesses commonly affect children and are the second most frequent reason for a child to be admitted to hospital. Most cases are viral in origin, usually with a good prognosis. Fever can be caused by severe and rapidly progressive illness which needs urgent referral to hospital for potentially life-saving treatment, and community practitioners must be able to identify such cases showing 'red flag'features. The fear of serious disease among parents and carers may result in 'fever phobia' leading to minor illnesses being managed inappropriately...
July 2015: Journal of Family Health
https://www.readbyqxmd.com/read/25962244/-the-effect-of-fever-on-blood-oxygen-saturation-in-children
#20
Dikla Zigdon Lahav, Elie Picard, Francis Mimouni, Leon Joseph, Shmuel Goldberg
INTRODUCTION: Blood temperature is inversely correlated with oxygen-hemoglobin affinity as demonstrated by in-vitro oxyhemoglobin dissociation curve (ODC) experimentation. OBJECTIVE: To evaluate the real-life effect of fever on blood oxygen saturation (SO2) in children. METHODS: Children treated in the Pediatric Emergency Department at the "Shaare Zedek" Medical Center with a body temperature > 38.50C were included in the study. Children suffering from active lung disease were excluded...
March 2015: Harefuah
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