keyword
https://read.qxmd.com/read/38500593/clinical-and-laboratory-parameters-associated-with-febrile-seizure-recurrence-within-the-first-24%C3%A2-h-a-ten-year-cohort-study
#1
JOURNAL ARTICLE
Massimo Luca Castellazzi, Adriano La Vecchia, Martina Scali, Carlo Agostoni, Giada Di Pietro, Gregorio Paolo Milani
INTRODUCTION: We assessed clinical and laboratory parameters associated with early recurrence of febrile seizure in patients presenting at the Emergency Department with a first episode. METHODS: Case series of patients admitted to the emergency department with the first episode of febrile seizure for ten consecutive years. Exclusion criteria were focal features and prolonged duration (>15 min). RESULTS: We included 693 patients, 284 (41%) female...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38454227/parents-knowledge-and-management-of-fever-parents-versus-fever
#2
JOURNAL ARTICLE
Taylan Çelik, Yusuf Güzel
OBJECTIVE: Parents' lack of knowledge about fever causes fear and incorrect practices. This study aims to investigate the fever knowledge level, concerns, and practices of parents of preschool children. MATERIALS AND METHODS: In this descriptive, cross-sectional study, conducted between July 2021 and July 2022, a survey was conducted among parents of children aged 6 months to 5 years who did not have a history of febrile seizure and/or chronic disease, either in themselves or their siblings...
March 2024: Turkish archives of pediatrics
https://read.qxmd.com/read/38197809/antipyretic-effects-of-xiangqin-jiere-granules-on-febrile-young-rats-revealed-by-combining-pharmacodynamics-metabolomics-network-pharmacology-molecular-biology-experiments-and-molecular-docking-strategies
#3
JOURNAL ARTICLE
Xiying He, Jieqiong Cui, Huayan Li, Yang Zhou, Xinchen Wu, Chunrong Jiang, Zhichang Xu, Ruirui Wang, Lei Xiong
Xiangqin Jiere granules (XQJRG) is a proprietary Chinese medicine treating children's colds and fevers, but its mechanism of action is unclear. The aim of this study was to explore the antipyretic mechanisms of XQJRG based on pharmacodynamics, non-targeted metabolomics, network pharmacology, molecular biology experiments, molecular docking, and molecular dynamics (MD) simulation. Firstly, the yeast-induced fever model was constructed in young rats to study antipyretic effect of XQJRG. Metabolomics and network pharmacology studies were performed to identify the key compounds, targets and pathways involved in the antipyretic of XQJRG...
January 10, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38077267/efficacy-of-oral-mefenamic-acid-versus-paracetamol-as-a-prophylactic-analgesic-for-needle-pain-in-children-receiving-vaccination-a-three-arm-parallel-triple-blind-placebo-controlled-map-vac-randomized-controlled-trial
#4
JOURNAL ARTICLE
Rachna Pasi, Thirunavukkarasu Arun Babu, Vinoth Kumar Kallidoss
BACKGROUND: Needle pain due to routine vaccination is an important factor contributing to low vaccine adherence and immunization coverage. Prophylactic oral analgesics can address this important issue of needle pain related to vaccination. Paracetamol and mefenamic acid are commonly used nonsteroidal anti-inflammatory drugs for pain relief, but there is little published literature on whether the same can be used for needle pain related to vaccination. OBJECTIVES: This study was planned to compare the efficacy of oral mefenamic acid and paracetamol over placebo as a prophylactic analgesic during vaccination and prophylactic antipyretic during the post-vaccination period...
2023: Therapeutic Advances in Vaccines and Immunotherapy
https://read.qxmd.com/read/38002578/ischemic-stroke-in-the-course-of-covid-19-in-a-16-year-old-boy
#5
Bartłomiej Syzdoł, Anna Maria Rzewuska, Wiktoria Sielwanowska, Monika Żybowska, Natalia Anna Wilczek, Magdalena Maria Woźniak
The SARS-CoV-2 virus that causes COVID-19 disease is still evolving and, despite the end of the acute phase of the pandemic, still poses a risk to public health. One of the very rare complications, occurring in less than 1% of children, is multisystem inflammatory syndrome in children (MISC). Due to the risk of thromboembolic complications as well as cardiac problems, MISC carries a number of life-threatening complications. We report a case of a 16-year-old boy who was hospitalized due to general weakness, fever, conjunctivitis, vomiting and diarrhoea...
November 7, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37986869/protocol-for-a-magnetic-resonance-imaging-mri-study-of-participants-in-the-fever-randomized-controlled-trial-does-fever-control-prevent-brain-injury-in-malaria
#6
Moses B Chilombe, Karl B Seydel, Colleen Hammond, Suzanna Mwanza, Archana A Patel, Frank Lungu, Somwe Wa Somwe, Sam Kampondeni, Michael J Potchen, Michael P McDermott, Gretchen L Birbeck
BACKGROUND: Despite eradication efforts, ∼135,000 African children sustained brain injuries as a result of central nervous system (CNS) malaria in 2021. Newer antimalarial medications rapidly clear peripheral parasitemia and improve survival, but mortality remains high with no associated decline in post-malaria neurologic injury. A randomized controlled trial of aggressive antipyretic therapy with acetaminophen and ibuprofen (Fever RCT) for malarial fevers being conducted in Malawi and Zambia began enrollment in 2019...
November 10, 2023: medRxiv
https://read.qxmd.com/read/37675390/determinants-of-caregiver-s-knowledge-and-practices-regarding-childhood-fever-management-in-a-developing-setting-a-multi-centre-cross-sectional-assessment
#7
JOURNAL ARTICLE
Ibrahim A Ogunyinka, Kazeem A Oshikoya, Kazeem B Yusuff, Yusuf Tahir, Mohammed Yahaya, Sulaiman B Adeniye, Innocent E Oforkansi
INTRODUCTION: Fever is both a sign of various diseases (chief of which are infectious in nature) and an adverse effect of certain interventions (e.g. vaccines, drugs) in the pediatric population. It elicits anxiety among caregivers and healthcare professionals alike resulting in non-evidence based practices, adverse medication administration events, waste of scarce resources and overutilization of health facilities. The determinants of these practices among caregivers in the domiciliary contexts have not been well characterized in developing settings...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/37589909/metamizole-induced-agranulocytosis-mia-a-mini-review
#8
REVIEW
Markos K Tomidis Chatzimanouil, Ines Goppelt, Yvonne Zeissig, Ulrich J Sachs, Martin W Laass
Metamizole is an analgesic, antipyretic, and spasmolytic drug in Germany only approved for the treatment of severe pain or high fever that does not respond to other measures. In recent years, an increased use has been described among both adults and children, often against the approved indication. The most important side effect of metamizole is the development of agranulocytosis (neutrophil count < 500/µL). Incidence of metamizole-induced agranulocytosis (MIA) ranges depending on the study from 0...
August 17, 2023: Molecular and Cellular Pediatrics
https://read.qxmd.com/read/37575900/clinical-characteristics-of-pediatric-inpatients-infected-with-the-sars-cov-2-omicron-variant-a-retrospective-observational-cohort-study
#9
JOURNAL ARTICLE
Xiang Gao, Debao Li, Xiuling Cheng, Xiaoxia Xin, Antonio F Corno, Alessandro Boscarelli, Xinping Du
BACKGROUND: The children infected with the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are at risk of progressing to severe disease. Clinical characteristics treatment measures and prognosis of these special age group of patients have not been completely understood which necessitate more researches. This study sought to analyze the clinical characteristics of children infected with the Omicron variant to provide evidences for the prevention, diagnosis and treatment of the Omicron variant infection in children...
July 31, 2023: Translational Pediatrics
https://read.qxmd.com/read/37485227/a-young-adult-with-multisystem-inflammatory-syndrome-following-weeks-of-initial-covid-19-respiratory-infection-with-no-prior-covid-19-vaccination-a-case-report
#10
Ans Ahmad, Mashal Maheshwari, Manas Gunani, Omer A Shaikh, Abdulqadir J Nashwan
Multisystem inflammatory syndrome (MIS) following COVID-19, a condition primarily diagnosed in children, has also been observed less frequently in adults. It usually presents with a multitude of symptoms, mimicking a shock-like state characterized by multiple organ failure. Diagnosis often involves ruling out other conditions and timely management to mitigate morbidity and mortality. In this case, a 39-year-old unvaccinated Caucasian male patient reported symptoms of fever, chills, night sweats, diarrhea, headache, nasal congestion, and facial pain...
June 2023: Curēus
https://read.qxmd.com/read/37474974/rdn-for-the-treatment-of-influenza-in-children-a-randomized-double-blinded-parallel-controlled-clinical-trial
#11
JOURNAL ARTICLE
Shuo Yang, Yan-Ming Xie, Lian-Xin Wang
BACKGROUND: The morbidity of influenza in children increased rapidly in decade. Reduning injection (RDN), a small but fine Chinese herbal formula, has antipyretic, antiviral, anti-inflammatory effects. We intend to evaluate the efficacy and safety of RDN for the influenza in children versus Oseltamivir, explore the possible antiviral mechanism of RDN and provide evidence-based medical evidence for rational clinical drug usage. METHOD: We design a randomized, double-blind, double-dummy, parallel control of positive drug, multi-centre clinical study...
July 20, 2023: BMC complementary medicine and therapies
https://read.qxmd.com/read/37436244/self-medication-in-children-aged-0-12-years-in-brazil-a-population-based-study
#12
JOURNAL ARTICLE
Emilia da Silva Pons, Tatiane da Silva Dal Pizzol, Daniela Riva Knauth, Sotero Serrate Mengue
OBJETIVE: Studies have shown that the practice of self-medicating children occurs worldwide and is independent of the country's economic level, medication policies, or access to health services. This study aimed to estimate and characterize the prevalence of self-medication in the Brazilian population of children aged up to 12 years. METHODS: We analyzed the data of 7528 children aged up to 12 years whose primary caregivers responded to the National Survey on Access, Use and Promotion of Rational Use of Medicines in Brazil (PNAUM), a cross-sectional population-based study conducted in 245 Brazilian municipalities...
2023: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://read.qxmd.com/read/37434807/gamma-globulin-combined-with-acyclovir-for-children-with-infectious-mononucleosis-and-their-effect-on-immune-function
#13
JOURNAL ARTICLE
Yuanyuan Li, Biquan Chen
BACKGROUND: Infectious mononucleosis (IM) is characterized by pharyngitis, cervical lymphadenopathy, fatigue and fever. IM is most commonly seen in primary Epstein-Barr virus (EBV) infection, with higher occurrence in children. OBJECTIVE: To explore the value of gamma globulin combined with acyclovir for IM children and their impact on immune function. METHODS: This prospective randomized controlled study recruited 111 children under 14 years old with IM from Anhui Provincial Children's Hospital during March 2019 and March 2022...
2023: American Journal of Translational Research
https://read.qxmd.com/read/37160780/management-of-children-with-febrile-seizures-a-greek-nationwide-survey
#14
JOURNAL ARTICLE
Ioannis Kopsidas, Foteini Eleni Dasoula, Eleni Kourkouni, Adamantia Krepi, Harry Α Mystakelis, Nikos Spyridis, George Vartzelis
UNLABELLED: The purpose of this study was to investigate knowledge, principles, and practices concerning the management of children with febrile seizures among pediatricians in Greece. A cross-sectional study was performed across Greece. Pediatricians completed an anonymous and voluntary 11-item questionnaire about their knowledge, attitudes, and practices with respect to the management of febrile seizures; the survey also collected demographic data. It was first administered in paper form in October 2017...
July 2023: European Journal of Pediatrics
https://read.qxmd.com/read/37055757/approach-to-fever-in-children-among-final-year-nursing-students-a-multicenter-survey
#15
JOURNAL ARTICLE
Gregorio P Milani, Antonio Corsello, Marta Fadda, Ilaria Falvo, Mario G Bianchetti, Diego Peroni, Elena Chiappini, Barbara Cantoni, Patrizio Sannino, Anne Destrebecq, Paola Marchisio
BACKGROUND: Unfounded concerns regarding fever are increasingly observed among nurses worldwide. However, no study has so far explored the preferred approach towards pediatric fever among nursing students. Therefore, we aimed to investigate the attitude towards pediatric fever among final-year nursing students. METHODS: Between February and June 2022, final-year nursing students of 5 Italian university hospitals were asked to answer an online survey on their approach to fever in children...
April 13, 2023: BMC Nursing
https://read.qxmd.com/read/36969272/discomfort-relief-after-paracetamol-administration-in-febrile-children-admitted-to-a-third-level-paediatric-emergency-department
#16
JOURNAL ARTICLE
Elena Chiappini, Matilde Bestetti, Stefano Masi, Teresa Paba, Elisabetta Venturini, Luisa Galli
BACKGROUND: international guidelines recommend treating fever in children not at a predefined body temperature limit but based on the presence of discomfort. However few studies evaluated discomfort relief after administration of antipyretics in children. METHODS: Between 1st January and 30th September 2021 a single-center prospective observational study was performed in febrile children consecutively admitted to a pediatric emergency department and treated with paracetamol orally...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/36867236/heart-rate-and-respiratory-rate-in-predicting-risk-of-serious-bacterial-infection-in-febrile-children-given-antipyretics-prospective-observational-study
#17
JOURNAL ARTICLE
Stefanie Wittmann, Rikke Jorgensen, Rianne Oostenbrink, Henriette Moll, Jethro Herberg, Mike Levin, Ian Maconochie, Ruud Nijman
Clinical algorithms used in the assessment of febrile children in the Paediatric Emergency Departments are commonly based on threshold values for vital signs, which in children with fever are often outside the normal range. Our aim was to assess the diagnostic value of heart and respiratory rate for serious bacterial infection (SBI) in children after temperature lowering following administration of antipyretics. A prospective cohort of children presenting with fever between June 2014 and March 2015 at the Paediatric Emergency Department of a large teaching hospital in London, UK, was performed...
March 3, 2023: European Journal of Pediatrics
https://read.qxmd.com/read/36777982/the-three-w-s-of-acetaminophen-in-children-who-why-and-which-administration-mode
#18
JOURNAL ARTICLE
Céline Thibault, Élaine Pelletier, Christina Nguyen, Evelyne D Trottier, Marie-Joëlle Doré-Bergeron, Kathryn DeKoven, Anne-Marie Roy, Nelson Piché, Jean-Francois Delisle, Caroline Morin, Julie Paquette, Niina Kleiber
Acetaminophen is one of the oldest medications commonly administered in children. Its efficacy in treating fever and pain is well accepted among clinicians. However, the available evidence supporting the use of acetaminophen's different modes of administration remains relatively scarce and poorly known. This short report summarizes the available evidence and provides a framework to guide clinicians regarding a rational use of acetaminophen in children.
2023: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/36739552/-modern-views-of-fever-management-about-the-feverfriendtm-program
#19
JOURNAL ARTICLE
Henrik Szőke, Ferenc Fekete, Tibor Kocsis, László Szijjártó, Zoltán Nyul, Ágnes Kiss, József Betlehem, Zsófia Verzár, János Hajdu Ráfis, Anikó Balogh
INTRODUCTION: A wealth of physiological, pathophysiological and clinical evidence of the beneficial effects of childhood fever exists already. Nevertheless, the public perception of fever has become persistently negative. Sociological research attributes this to a number of factors: unjustified fear, help-seeking behaviour, complex behavioural patterns of symptom avoidance and comfort-seeking. One of the keys to this change in attitudes, in the light of recent research, is linked to changes in the awareness and understanding of health among health professionals and lay people...
February 5, 2023: Orvosi Hetilap
https://read.qxmd.com/read/36494236/determining-the-fever-related-knowledge-and-practices-of-mothers-with-children-aged-1-5-years-presenting-to-a-child-emergency-service-with-fever-complaints-in-turkiye
#20
JOURNAL ARTICLE
Meryem Kayhanlar Gulcan, Nejla Canbulat Sahiner
PURPOSE: This study aimed to evaluate and determine the knowledge and practices of mothers with children aged between 1 and 5 years presenting to a pediatric emergency service with fever complaints regarding fever management. DESIGN AND METHODS: This study was descriptive and correlational study was conducted between March and May 2019 with mothers over the age of 18 who brought their children aged 1-5 years to the XX State Hospital Pediatric Emergency Department with fever complaints...
December 6, 2022: Journal of Pediatric Nursing
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