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https://www.readbyqxmd.com/read/28078247/effects-of-biebersteinia-multifida-hydro-ethanol-extract-on-proliferation-and-apoptosis-of-human-prostate-cancer-and-human-embryonic-kidney-cells
#1
Alireza Golshan, Samira Hassanzadeh, Maryam Mojdekanloo, Zahra Tayarani-Najaran
OBJECTIVE: Biebersteinia (Geraniaceae) has a history of use in traditional medicine in some countries including Iran. In the present study, cytotoxic and apoptogenic properties of hydro-ethanol extract of B. multifidi was investigated on human prostate cancer cell lines (PC3 and DU 145) and human embryonic kidney 293 (HEK293) cells. MATERIALS AND METHODS: Cells were cultured in RPMI-1640 medium supplemented with 10% FBS at 37ºC in a humidified atmosphere of 95% air and 5% CO2...
November 2016: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28072853/terrestrial-macrofungal-diversity-from-the-tropical-dry-evergreen-biome-of-southern-india-and-its-potential-role-in-aerobiology
#2
Hema Priyamvada, M Akila, Raj Kamal Singh, R Ravikrishna, R S Verma, Ligy Philip, R R Marathe, L K Sahu, K P Sudheer, S S Gunthe
Macrofungi have long been investigated for various scientific purposes including their food and medicinal characteristics. Their role in aerobiology as a fraction of the primary biological aerosol particles (PBAPs), however, has been poorly studied. In this study, we present a source of macrofungi with two different but interdependent objectives: (i) to characterize the macrofungi from a tropical dry evergreen biome in southern India using advanced molecular techniques to enrich the database from this region, and (ii) to assess whether identified species of macrofungi are a potential source of atmospheric PBAPs...
2017: PloS One
https://www.readbyqxmd.com/read/28071986/evaluation-of-a-two-year-routine-application-of-molecular-testing-of-thyroid-fine-needle-aspirations-fna-using-a-7-gene-panel-in-a-primary-referral-setting-in-germany
#3
Markus Eszlinger, Katharina Böhme, Maha Ullmann, Fabian Görke, Udo Siebolts, Anna Neumann, Christiane Franzius, Sabine Adam, Thomas Molwitz, Christian Landvogt, Bassam Amro, Anja Hach, Berit Feldmann, Dieter Graf, Antje Wefer, Rainer Niemann, Catharina Bullmann, Günther Klaushenke, Reinhard Santen, Gregor Tönshoff, Velimir Ivancevic, Andreas Kögler, Eberhard Bell, Bernd Lorenz, Gerald Kluge, Christoph Hartenstein, Ilka Ruschenburg, Ralf Paschke
BACKGROUND: Major differences with respect to the diagnostic performance of a "ruling in" approach in the pre-surgical diagnosis of indeterminate thyroid fine needle aspirations (FNAs) have been reported. Therefore, the aim of this prospective multicenter study was to investigate the specific diagnostic impact of mutation testing using a 7-gene-panel in a routine primary referral setting analyzing FNAs from endocrinology and nuclear medicine practices in Germany. METHODS: RNA and DNA was extracted from 564 routine air-dried FNA smears obtained from 64 physicians and cytologically graded by one experienced cytopathologist...
January 10, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28061918/clinical-experience-and-learning-style-of-flight-nurse-and-aeromedical-evacuation-technician-students
#4
Marla J De Jong, Susan F Dukes, Karey M Dufour, Darcy L Mortimer
BACKGROUND: The clinical experience and preferred learning style of U.S. Air Force flight nurses and aeromedical evacuation technicians are unknown. METHODS: Using a cross-sectional survey design, we gathered data regarding the clinical experience, level of comfort providing clinical care, and preferred learning style of 77 active duty (AD), Air Force Reserve (AFR), and Air National Guard (ANG) nurses enrolled in the U.S. Air Force School of Aerospace Medicine Flight Nurse course, and 121 AD, AFR, and ANG medical technicians enrolled in the Aeromedical Evacuation Technician course...
January 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28053516/psychometric-properties-of-the-anxiety-inventory-for-respiratory-disease-in-patients-with-copd-in-china
#5
Xiao-Yan Dong, Lan Wang, Yan-Xia Tao, Xiu-Li Suo, Yue-Chuan Li, Fang Liu, Yue Zhao, Qing Zhang
BACKGROUND: Anxiety is a common comorbidity in patients with COPD in China, and it can significantly decrease patients' quality of life. Almost all anxiety measurements contain somatic items that can overlap with symptoms of COPD and side effects of medicines, which can lead to bias in measuring anxiety in patients with COPD. Therefore, a brief and disease-specific non-somatic anxiety measurement scale, the Anxiety Inventory for Respiratory Disease (AIR), which has been developed and validated in its English version, is needed for patients with COPD in China...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28051764/the-use-of-fibrin-sealant-during-non-emergency-surgery-a-systematic-review-of-evidence-of-benefits-and-harms
#6
Steven J Edwards, Fay Crawford, Michelle Helena van Velthoven, Andrea Berardi, George Osei-Assibey, Mariana Bacelar, Fatima Salih, Victoria Wakefield
BACKGROUND: Fibrin sealants are used in different types of surgery to prevent the accumulation of post-operative fluid (seroma) or blood (haematoma) or to arrest haemorrhage (bleeding). However, there is uncertainty around the benefits and harms of fibrin sealant use. OBJECTIVES: To systematically review the evidence on the benefits and harms of fibrin sealants in non-emergency surgery in adults. DATA SOURCES: Electronic databases [MEDLINE, EMBASE and The Cochrane Library (including the Cochrane Database of Systematic Reviews, the Database of Abstracts of Reviews of Effects, the Health Technology Assessment database and the Cochrane Central Register of Controlled Trials)] were searched from inception to May 2015...
December 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28039501/comparison-of-dexamethasone-dimenhydrinate-and-dexamethasone-ondansetron-in-prevention-of-nausea-and-vomiting-in-postoperative-patients
#7
Nurcan Kizilcik, Sevgi Bilgen, Ferdi Menda, Hatice Türe, Bilgehan Aydın, Elif Cigdem Kaspar, Ozge Koner
INTRODUCTION: Postoperative Nausea and Vomiting is one of the most common problems after implementation of general anesthesia. The incidence can reach 80% in high-risk patients, depending on the type of surgery. In our study, we aimed to compare dexamethasone-dimenhydrinate and dexamethasone-ondansetron combinations in prevention of nausea and vomiting in postoperative patients. METHOD: Sixty 18-65-year-olds ASAI-II females who underwent rhinoplasty were included in the study...
December 30, 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28035474/technical-note-early-post-mortem-changes-of-human-bone-in-taphonomy-with-%C3%AE-ct
#8
Erwan Le Garff, Vadim Mesli, Yann Delannoy, Thomas Colard, Xavier Demondion, Anne Becart, Valéry Hedouin
Post-mortem interval (PMI) estimation is an important issue in forensic medicine, particularly for criminal purposes and legal limitation periods. The goal of the present study is to examine the evolution of the trabecular cranial vault bone after 4 weeks of conservation in a controlled environment with micro-tomography (μCT) analyses.Four bone samples were extracted from a fresh human cranial vault (a donation to science according to the French law) and conserved in an air-controlled environment. The samples were weighed and μCT scanned at a 10-μm resolution every week after death for a month...
December 29, 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28032142/overlooking-relevant-confounders-in-the-assessment-of-pesticides-and-human-health-a-reply-to-mostafalou-and-abdollahi
#9
EDITORIAL
Keith Fluegge
Mostafalou and Abdollahi (Arch Toxicol, 2016. doi: 10.1007/s00204-016-1849-x ) have recently conducted a review exploring human exposure to pesticides and systematically highlighting known toxic mechanisms from these exposures. Their review is extensive and appraises the literature on pesticide toxicity in a number of domains, including neurotoxicity and developmental toxicity. However, as important as it may be to understand the toxicological potential of these chemicals in humans and other species, the role of these chemicals as proxies for other environmental exposures should not be excluded...
December 28, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27986496/medical-diagnostics-for-indoor-mold-exposure
#10
REVIEW
Julia Hurraß, Birger Heinzow, Ute Aurbach, Karl-Christian Bergmann, Albrecht Bufe, Walter Buzina, Oliver A Cornely, Steffen Engelhart, Guido Fischer, Thomas Gabrio, Werner Heinz, Caroline E W Herr, Jörg Kleine-Tebbe, Ludger Klimek, Martin Köberle, Herbert Lichtnecker, Thomas Lob-Corzilius, Rolf Merget, Norbert Mülleneisen, Dennis Nowak, Uta Rabe, Monika Raulf, Hans Peter Seidl, Jens-Oliver Steiß, Regine Szewszyk, Peter Thomas, Kerttu Valtanen, Gerhard A Wiesmüller
In April 2016, the German Society of Hygiene, Environmental Medicine and Preventative Medicine (Gesellschaft für Hygiene, Umweltmedizin und Präventivmedizin (GHUP)) together with other scientific medical societies, German and Austrian medical societies, physician unions and experts has provided an AWMF (Association of the Scientific Medical Societies) guideline 'Medical diagnostics for indoor mold exposure'. This guideline shall help physicians to advise and treat patients exposed indoors to mold. Indoor mold growth is a potential health risk, even without a quantitative and/or causal association between the occurrence of individual mold species and health effects...
December 5, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27915048/protective-effects-of-green-tea-and-its-main-constituents-against-natural-and-chemical-toxins-a-comprehensive-review
#11
REVIEW
Maryam Rameshrad, Bibi Marjan Razavi, Hossein Hosseinzadeh
Toxins are natural or chemical poisonous substances with severe side effects on health. Humans are generally exposed by widespread toxic contaminations via air, soil, water, food, fruits and vegetables. Determining a critical antidote agent with extensive effects on different toxins is an ultimate goal for all toxicologists. Traditional medicine is currently perceived as a safe and natural approach against toxins. In this regard, we focused on the protective effects of green tea (Camellia sinensis) and its main components such as catechin, epicatechin, epicatechin gallate, gallocatechin, epigallocatechin and epigallocatechin gallate as a principal source of antioxidants against both natural and chemical toxins...
December 1, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27882031/diagnostic-value-and-disease-evaluation-significance-of-abdominal-ultrasound-inspection-for-neonatal-necrotizing-enterocolitis
#12
Li Wang, Yinghui Li, Jian Liu
OBJECTIVE: To summarize abdominal plain X-rays and ultrasound characteristics of 144 cases of Neonatal Necrotizing Enterocolitis (NEC) and to analyze diagnostic value and disease evaluation significance of abdominal ultrasound inspection for NEC. METHODS: Clinical data of 144 NEC patients were retrospectively analyzed from February 2014 to December 2015. The patients were divided into suspected NEC group (N=74) and confirmed NEC group (N=70) according to amended Bell-NEC classification and diagnostic criteria...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27878968/proprotein-convertase-inhibition-promotes-ciliated-cell-differentiation-a-potential-mechanism-for-the-inhibition-of-notch1-signalling-by-decanoyl-rvkr-chloromethylketone
#13
Sang-Nam Lee, In-Suk Choi, Hyun Jun Kim, Eun Jin Yang, Hyun Jin Min, Joo-Heon Yoon
Chronic repetitive rounds of injury and repair in the airway lead to airway remodelling, including ciliated cell loss and mucous cell hyperplasia. Airway remodelling is mediated by many growth and differentiation factors including Notch1, which are proteolytically processed by proprotein convertases (PCs). The present study evaluated a novel approach for controlling basal cell-type determination based on the inhibition of PCs. It was found that decanoyl-RVKR-chloromethylketone (CMK), a PC inhibitor, promotes ciliated cell differentiation and has no effect on the ciliary beat frequency in air-liquid interface (ALI) cultures of human nasal epithelial cells (HNECs)...
November 22, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27863612/complementary-and-alternative-medicine-use-in-children-with-cystic-fibrosis
#14
Sandra Giangioppo, Odion Kalaci, Arun Radhakrishnan, Erin Fleischer, Jennifer Itterman, Brian Lyttle, April Price, Dhenuka Radhakrishnan
PURPOSE: To estimate the overall prevalence of complementary and alternative medicine use among children with cystic fibrosis, determine specific modalities used, predictors of use and subjective helpfulness or harm from individual modalities. RESULTS: Of 53 children attending the cystic fibrosis clinic in London, Ontario (100% recruitment), 79% had used complementary and alternative medicine. The most commonly used modalities were air purifiers, humidifiers, probiotics, and omega-3 fatty acids...
November 2016: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/27854196/determination-of-flavonoids-polyphenols-and-antioxidant-activity-of-tephrosia-purpurea-a-seasonal-study
#15
Madan Mohan Pandey, Sayyada Khatoon, Subha Rastogi, Ajay Kumar Singh Rawat
OBJECTIVE: Tephrosia purpurea (Linn·) Pers. is widely used in traditional medicine to treat liver disorders, febrile attacks, enlargement and obstruction of liver, spleen, and kidney. In the present study, investigations were carried out to determine the seasonal impact on the content of flavonoid glycosides and on antioxidant activities so as to identify the optimal time of harvesting. METHODS: The plant materials were collected in different seasons during 2013-2014...
November 2016: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27833680/blog-and-podcast-watch-neurologic-emergencies
#16
Andrew Grock, Nikita Joshi, Anand Swaminathan, Salim Rezaie, Chris Gaafary, Michelle Lin
INTRODUCTION: The WestJEM Blog and Podcast Watch presents high quality open-access educational blogs and podcasts in emergency medicine (EM) based on the ongoing ALiEM Approved Instructional Resources (AIR) and AIR-Professional series. Both series critically appraise resources using an objective scoring rubric. This installment of the Blog and Podcast Watch highlights the topic of neurologic emergencies from the AIR series. METHODS: The AIR series is a continuously building curriculum that follows the Council of Emergency Medicine Residency Director's (CORD) annual testing schedule...
November 2016: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27817868/occurrence-of-phthalate-esters-in-over-the-counter-medicines-from-china-and-its-implications-for-human-exposure
#17
Lu-Lu Jia, Xiang-Ying Lou, Ying Guo, Kelvin Sze-Yin Leung, Eddy Y Zeng
Food, air, personal care products and indoor dust have been recognized as the main routes of exposure to phthalates in Chinese population, but other sources may have been overlooked, e.g., medicines. To fill the knowledge gap, phthalate esters were measured in 96 over-the-counter medicines made in China, including selected 71 Chinese patented medicines and 25 western medicines. It was found that none of the medicines was free of phthalates. The mean concentrations of individual phthalates ranged from 0.001μg/g (dicyclohexyl phthalate) to 5...
November 3, 2016: Environment International
https://www.readbyqxmd.com/read/27815629/pulmonary-artery-perforation-and-coronary-air-embolism-two-fatal-outcomes-in-percutaneous-left-atrial-appendage-occlusion
#18
J Zwirner, R Bayer, C Hädrich, A Bollmann, N Klein, J Dreßler, B Ondruschka
Percutaneous left atrial appendage (LAA) closure is a routinely performed method to reduce the risk of stroke in patients suffering from atrial fibrillation, when an oral anticoagulation is no longer indicated due to relevant bleeding complications. Currently, the Amplatzer Amulet and the Watchman system are two equally used systems. While there is an acute success rate of more than 95 per cent for this intervention, several minor and major complications such as pericardial effusions, air embolism, vascular lesions in proximity to the heart or even death can occur...
January 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27811481/dose-and-time-dependent-cellular-effects-of-cold-atmospheric-pressure-plasma-evaluated-in-3d-skin-models
#19
Cornelia Wiegand, Sarah Fink, Oliver Beier, Kerstin Horn, Andreas Pfuch, Arnd Schimanski, Bernd Grünler, Uta-Christina Hipler, Peter Elsner
BACKGROUND: Application of cold atmospheric pressure plasmas (CAPs) in or on the human body was termed 'plasma medicine'. So far, plasmas were utilized for sterilization of implants, other heat-sensitive products, or employed for chemical surface modifications. By now, CAPs are further used effectively for wound treatment. The present study analyses the effect of a plasma jet with air or nitrogen as process gas, previously evaluated for antimicrobial efficacy, on human cells using a 3D skin model...
2016: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/27807020/miliary-tuberculosis-in-an-immunocompetent-male-with-a-fatal-outcome
#20
Louise Dunphy, Elizabeth Keating, T Parke
A man aged 33 years, born in Nepal, but resident in the UK for 7 years presented to the emergency department with a 4-day history of general malaise, fever (temperature 38.6°C) and a non-productive cough. His medical history was unremarkable and no high-risk behaviour was identified. Clinical examination confirmed decreased air entry bilaterally with bibasal crackles. He was tachycardic, with a heart rate of 120 bpm. Further investigation with a 12-lead ECG confirmed supraventricular tachycardia (SVT) which was terminated with vagal manoeuvres...
November 2, 2016: BMJ Case Reports
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