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Cognitive Assessment System

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https://www.readbyqxmd.com/read/28729927/fatigue-and-cognition-pupillary-responses-to-problem-solving-in-early-multiple-sclerosis-patients
#1
Sigrid A de Rodez Benavent, Gro O Nygaard, Hanne F Harbo, Siren Tønnesen, Piotr Sowa, Nils I Landrø, Marte Wendel-Haga, Lars Etholm, Kristian B Nilsen, Liv Drolsum, Emilia Kerty, Elisabeth G Celius, Bruno Laeng
INTRODUCTION: In early multiple sclerosis (MS) patients, cognitive changes and fatigue are frequent and troublesome symptoms, probably related to both structural and functional brain changes. Whether there is a common cause of these symptoms in MS is unknown. In theory, an altered regulation of central neuropeptides can lead to changes in regulation of autonomic function, cognitive difficulties, and fatigue. Direct measurements of central neuropeptides are difficult to perform, but measurements of the eye pupil can be used as a reliable proxy of function...
July 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28729220/cognitive-enhancement-and-antipsychotic-like-activity-following-repeated-dosing-with-the-selective-m4-pam-vu0467154
#2
Robert W Gould, Michael D Grannan, Barak W Gunter, Jacob Ball, Michael Bubser, Thomas M Bridges, Jurgen Wess, Michael W Wood, Nicholas J Brandon, Mark E Duggan, Colleen M Niswender, Craig W Lindsley, P Jeffrey Conn, Carrie K Jones
Although selective activation of the M1 muscarinic acetylcholine receptor (mAChR) subtype has been shown to improve cognitive function in animal models of neuropsychiatric disorders, recent evidence suggests that enhancing M4 mAChR function can also improve memory performance. Positive allosteric modulators (PAMs) targeting the M4 mAChR subtype have shown therapeutic potential for the treatment of multiple symptoms observed in schizophrenia, including positive and cognitive symptoms when assessed in acute preclinical dosing paradigms...
July 17, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28727640/no-seasonal-changes-in-cognitive-functioning-among-high-school-football-athletes-implementation-of-a-novel-electrophysiological-measure-and-standard-clinical-measures
#3
Steven P Broglio, Richelle Williams, Ashley Rettmann, Brandon Moore, James T Eckner, Sean Meehan
OBJECTIVE: To evaluate neuroelectric and cognitive function relative to a season of football participation. Cognitive and neuroelectric function declines are hypothesized to be present in football athletes. DESIGN: Observational. SETTING: Athletic fields and research laboratory. PATIENTS (OR PARTICIPANTS): Seventy-seven high school athletes (15.9 + 0.9 years, 178.6 + 7.2 cm, 74.4 + 14.7 kg, and 0.8 + 0.8 self-reported concussions) participating in football (n = 46) and noncontact sports (n = 31)...
July 14, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28725201/nature-and-specificity-of-gestural-disorder-in-children-with-developmental-coordination-disorder-a-multiple-case-study
#4
Orianne Costini, Arnaud Roy, Chrystelle Remigereau, Sylvane Faure, Catherine Fossoud, Didier Le Gall
Aim: Praxis assessment in children with developmental coordination disorder (DCD) is usually based on tests of adult apraxia, by comparing across types of gestures and input modalities. However, the cognitive models of adult praxis processing are rarely used in a comprehensive and critical interpretation. These models generally involve two systems: a conceptual system and a production system. Heterogeneity of deficits is consistently reported in DCD, involving other cognitive skills such as executive or visual-perceptual and visuospatial functions...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28720898/balance-training-improves-memory-and-spatial-cognition-in-healthy-adults
#5
Ann-Kathrin Rogge, Brigitte Röder, Astrid Zech, Volker Nagel, Karsten Hollander, Klaus-Michael Braumann, Kirsten Hötting
Physical exercise has been shown to improve cognitive functions. However, it is still unknown which type of exercise affects cognition. In the present study, we tested the hypothesis that a demanding balance training program improves memory and spatial cognition. Forty healthy participants aged 19-65 years were randomly assigned to either a balance or relaxation training intervention. Each group exercised twice a week for a total of 12 weeks. Pre- and posttests assessed balance performance, cardiorespiratory fitness, memory, spatial cognition, and executive functions...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720484/long-term-enzyme-replacement-therapy-improves-neurocognitive-functioning-and-hippocampal-synaptic-plasticity-in-immune-tolerant-alpha-mannosidosis-mice
#6
Stijn Stroobants, Markus Damme, Ann Van der Jeugd, Ben Vermaercke, Claes Andersson, Jens Fogh, Paul Saftig, Judith Blanz, Rudi D'Hooge
Alpha-mannosidosis is a glycoproteinosis caused by deficiency of lysosomal acid alpha-mannosidase (LAMAN), which markedly affects neurons of the central nervous system (CNS), and causes pathognomonic intellectual dysfunction in the clinical condition. Cognitive improvement consequently remains a major therapeutic objective in research on this devastating genetic error. Immune-tolerant LAMAN knockout mice were developed to evaluate the effects of enzyme replacement therapy (ERT) by prolonged administration of recombinant human enzyme...
July 15, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28719854/clinically-silent-alzheimer-s-and-vascular-pathologies-influence-brain-networks-supporting-executive-function-in-healthy-older-adults
#7
Brian T Gold, Christopher A Brown, Jonathan G Hakun, Leslie M Shaw, John Q Trojanowski, Charles D Smith
Aging is associated with declines in executive function. We examined how executive functional brain systems are influenced by clinically silent Alzheimer's disease (AD) pathology and cerebral white-matter hyperintensities (WMHs). Twenty-nine younger adults and 34 cognitively normal older adults completed a working memory paradigm while functional magnetic resonance imaging was performed. Older adults further underwent lumbar cerebrospinal fluid draw for the assessment of AD pathology and FLAIR imaging for the assessment of WMHs...
June 24, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28717229/investigation-of-autistic-traits-through-strategic-decision-making-in-games-with-adaptive-agents
#8
Alexis B Craig, Emily Grossman, Jeffrey L Krichmar
Autism Spectrum Disorders are characterized by difficulties in communicating and cooperating with other people. Impairment in Theory of Mind (ToM), the ability to infer what another person is thinking, may contribute to these social deficits. The present study assesses the relationship between autistic traits and decision-making in a socioeconomic game environment that measures ToM and cooperation. We quantified participant strategy during game play with computer agents that simulated aspects of ToM or fixed strategy agents with static behaviors or heuristics...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28715141/walnut-consumption-increases-activation-of-the-insula-to-highly-desirable-food-cues-a-randomized-double-blind-placebo-controlled-cross-over-fmri-study
#9
Olivia M Farr, Dario Tuccinardi, Jagriti Upadhyay, Sabrina M Oussaada, Christos S Mantzoros
AIMS: The use of walnuts is recommended for obesity and type 2 diabetes, although the mechanisms through which walnuts may improve appetite and/or glycemic control remain largely unknown. MATERIALS AND METHODS: To determine whether short-term walnut consumption could alter the neural control of appetite using functional magnetic resonance imaging, we performed a randomized, placebo-controlled, double-blind, cross-over trial of 10 patients who received, while living in the controlled environment of a clinical research center, either walnuts or placebo (using a validated smoothie delivery system) for 5 days each, separated by a wash-out period of one month...
July 17, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28715105/a-simulation-based-approach-to-measuring-team-situational-awareness-in-emergency-medicine-a-multicenter-observational-study
#10
Elizabeth D Rosenman, Aurora J Dixon, Jessica M Webb, Sarah Brolliar, Simon J Golden, Kerin A Jones, Sachita Shah, James A Grand, Steve W J Kozlowski, Georgia T Chao, Rosemarie Fernandez
OBJECTIVES: Team situational awareness (TSA) is critical for effective teamwork and supports dynamic decision-making in unpredictable, time-pressured situations. Simulation provides a platform for developing and assessing TSA; but these efforts are limited by suboptimal measurement approaches. The objective of this study was to develop and evaluate a novel approach to TSA measurement in interprofessional emergency medicine teams. METHODS: We performed a multicenter, prospective, simulation-based observational study to evaluate an approach to TSA measurement...
July 17, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28711424/conversion-and-reversion-rates-in-japanese-older-people-with-mild-cognitive-impairment
#11
Hiroyuki Shimada, Hyuma Makizako, Takehiko Doi, SungChul Lee, Sangyoon Lee
OBJECTIVES: Approximately 25% of individuals who are diagnosed with amnestic mild cognitive impairment (aMCI) revert to normal cognition (NC) rather than progressing to Alzheimer disease (AD). However, the prevalence of progression and reversion among older people in Asia remains unclear. DESIGN: A prospective cohort study. SETTING: A community in Japan. PARTICIPANTS: A total of 4153 individuals without dementia aged ≥65 years were classified as having NC, aMCI single domain (aMCIs), non-aMCI single domain (naMCIs), aMCI multiple domain (aMCIm), non-aMCI multiple domain (naMCIm), or global cognitive impairment (GCI)...
July 12, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28710800/dissociation-of-spatial-memory-systems-in-williams-syndrome
#12
Mathilde Bostelmann, Emilie Fragnière, Floriana Costanzo, Silvia Di Vara, Deny Menghini, Stefano Vicari, Pierre Lavenex, Pamela Banta Lavenex
Williams syndrome (WS), a genetic deletion syndrome, is characterized by severe visuospatial deficits affecting performance on both tabletop spatial tasks and on tasks which assess orientation and navigation. Nevertheless, previous studies of WS spatial capacities have ignored the fact that two different spatial memory systems are believed to contribute parallel spatial representations supporting navigation. The place learning system depends on the hippocampal formation and creates flexible relational representations of the environment, also known as cognitive maps...
July 15, 2017: Hippocampus
https://www.readbyqxmd.com/read/28708697/simultaneous-physical-and-mental-effort-alters-visual-function
#13
Jesús Vera, Raimundo Jiménez, José Antonio García, David Cárdenas
PURPOSE: Perceptual processing is sensitive to physiological changes. Thus, the homeostatic disturbances during and after exercise may alter the visual function. Here, we investigated the effect of simultaneous physical effort and two levels of cognitive demand on skills related to the visuoperceptual and motor processing. METHODS: Eighteen male regular exercisers performed 60 minutes of simultaneous physical exercise (cycling at 60 ± 5% of reserve heart rate) and cognitive effort (mental workload)...
July 14, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28708033/neuropsychological-profile-and-social-cognition-in-congenital-central-hypoventilation-syndrome-cchs-correlation-with-neuroimaging-in-a-clinical-case
#14
Borja Esteso Orduña, Raquel Seijas Gómez, Elena García Esparza, Emily M Briceño, Javier Melero Llorente, María de la Concepción Fournier Del Castillo
INTRODUCTION: Congenital central hypoventilation syndrome (CCHS) is a rare genetic disorder due to paired-like homeobox gene (PHOX2B) mutations. CCHS patients suffer from dysregulation of the autonomic nervous system characterized by the absence of or extremely reduced response to hypercapnia and hypoxia, with neuropsychological deficits. The aim of this exploratory study is to describe the longitudinal neuropsychological profile and its correlations with magnetic resonance imaging (MRI) of a child with CCHS with a PHOX2B mutation...
July 14, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28708004/psychological-trait-resilience-within-ecological-systems-theory-the-resilient-systems-scales
#15
John Maltby, Liz Day, Heather D Flowe, Panos Vostanis, Sally Chivers
This project describes the development of the Resilient Systems Scales, created to address conceptual and methodological ambiguities in assessing the ecological systems model of resilience. Across a number of samples (total N = 986), our findings suggest that the Resilient Systems Scales show equivalence to a previously reported assessment (Maltby, Day, & Hall, 2015 ) in demonstrating the same factor structure, adequate intercorrelation between the 2 measures of resilience, and equivalent associations with personality and well-being...
July 14, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28707953/neural-correlates-of-visual-memory-in-patients-with-diffuse-axonal-injury
#16
Juliane Lauer, Laura Moreno-López, Anne Manktelow, Ellen L Carroll, Joanne G Outtrim, Jonathan P Coles, Virginia F Newcombe, Barbara J Sahakian, David K Menon, Emmanuel A Stamatakis
PRIMARY OBJECTIVE: To investigate the neural substrates of visual memory in a sample of patients with traumatic brain injury (TBI). We hypothesized that patients with decreased grey and white matter volume in frontal and parietal cortices as well as medial temporal and occipital lobes would perform poorly on the tests of visual memory analysed. METHODS AND PROCEDURES: 39 patients and 53 controls were assessed on tests of visual memory and learning from the Cambridge Neuropsychological Test Automated Battery (CANTAB)...
July 14, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28707495/individualizing-the-selection-of-long-acting-bronchodilator-therapy-for-patients-with-copd-considerations-in-primary-care
#17
Brian W Carlin, Sandra K Schuldheisz, Imre Noth, Gerard J Criner
Chronic obstructive pulmonary disease (COPD) is a common condition encountered in primary care settings. COPD remains the third leading cause of death in the United States and carries a significant burden to both patients and the healthcare system. COPD is a chronic, progressive, irreversible lung disease associated with high morbidity and mortality. Proper assessment and diagnosis requires spirometry which is currently underutilized in primary care. Management is focused on adequate symptom control, improving quality of breathing and quality of life, and preventing exacerbations and hospitalizations...
July 14, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28707048/psychometric-evaluation-of-an-item-bank-for-computerized-adaptive-testing-of-the-eortc-qlq-c30-cognitive-functioning-dimension-in-cancer-patients
#18
Linda Dirven, Mogens Groenvold, Martin J B Taphoorn, Thierry Conroy, Krzysztof A Tomaszewski, Teresa Young, Morten Aa Petersen
BACKGROUND: The European Organisation of Research and Treatment of Cancer (EORTC) Quality of Life Group is developing computerized adaptive testing (CAT) versions of all EORTC Quality of Life Questionnaire (QLQ-C30) scales with the aim to enhance measurement precision. Here we present the results on the field-testing and psychometric evaluation of the item bank for cognitive functioning (CF). METHODS: In previous phases (I-III), 44 candidate items were developed measuring CF in cancer patients...
July 13, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28706740/action-video-game-experience-related-to-altered-large-scale-white-matter-networks
#19
Diankun Gong, Weiyi Ma, Jinnan Gong, Hui He, Li Dong, Dan Zhang, Jianfu Li, Cheng Luo, Dezhong Yao
With action video games (AVGs) becoming increasingly popular worldwide, the cognitive benefits of AVG experience have attracted continuous research attention over the past two decades. Research has repeatedly shown that AVG experience can causally enhance cognitive ability and is related to neural plasticity in gray matter and functional networks in the brain. However, the relation between AVG experience and the plasticity of white matter (WM) network still remains unclear. WM network modulates the distribution of action potentials, coordinating the communication between brain regions and acting as the framework of neural networks...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28706727/pd_manager-an-mhealth-platform-for-parkinson-s-disease-patient-management
#20
Kostas M Tsiouris, Dimitrios Gatsios, George Rigas, Dragana Miljkovic, Barbara Koroušić Seljak, Marko Bohanec, Maria T Arredondo, Angelo Antonini, Spyros Konitsiotis, Dimitrios D Koutsouris, Dimitrios I Fotiadis
PD_Manager is a mobile health platform designed to cover most of the aspects regarding the management of Parkinson's disease (PD) in a holistic approach. Patients are unobtrusively monitored using commercial wrist and insole sensors paired with a smartphone, to automatically estimate the severity of most of the PD motor symptoms. Besides motor symptoms monitoring, the patient's mobile application also provides various non-motor self-evaluation tests for assessing cognition, mood and nutrition to motivate them in becoming more active in managing their disease...
June 2017: Healthcare Technology Letters
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