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Noise induced hearing loss

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https://www.readbyqxmd.com/read/29775022/-establishment-of-the-characterization-of-an-adult-digits-in-noise-test-based-on-internet
#1
B E Qi, T B Zhang, X X Fu, G P Li
Objective: The aim of this study is to explore the sensitivity and specificity of the internet-based digital noise threshold (DIN) test for detecting noise-induced hearing loss, expecting to provide a rapid and effective screening tool for clinical application. Method: This study enrolled 50 adult subjects, of which 34 were normal hearing (NH), 16 patients with sensorineural hearing loss (SNHL). Pure-tone audiometry, acoustic immittance and DIN test were tested respectively. Pearson's correlation coefficient was used to analyze the correlation between NH and SNHL...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29760588/in-vitro-gentamicin-exposure-alters-caveolae-protein-profile-in-cochlear-spiral-ligament-pericytes
#2
Elisa Ghelfi, Yohann Grondin, Emil J Millet, Adam Bartos, Magda Bortoni, Clara Oliveira Gomes Dos Santos, Humberto J Trevino-Villarreal, Rosalinda Sepulveda, Rick Rogers
Background: The aminoglycoside antibiotic gentamicin is an ototoxic drug and has been used experimentally to investigate cochlear damage induced by noise.We have investigated the changes in the protein profile associated with caveolae in gentamicin treated and untreated spiral ligament (SL) pericytes, specialized cells in the blood labyrinth barrier of the inner ear microvasculature. Pericytes from various microvascular beds express caveolae, protein and cholesterol rich microdomains, which can undergo endocytosis and transcytosis to transport small molecules in and out the cells...
2018: Proteome Science
https://www.readbyqxmd.com/read/29747961/the-protective-effect-of-adrenocorticotropic-hormone-treatment-against-noise-induced-hearing-loss
#3
Ahmet Mutlu, Fatma Ceyda Akin Ocal, Seyra Erbek, Levent Ozluoglu
OBJECTIVE: NIHL is a common problem, and steroids are the most effective treatment option. In this study, we aimed to evaluate the protective effects of the synthetic adrenocorticotropic hormone (ACTH) analogues, which induce endogenous steroid secretion, against noise-induced hearing loss (NIHL) and to compare their effectiveness with that of steroid treatment. METHODS: Twenty-four male Sprague-Dawley albino rats were divided into four subgroups as follows: group 1 (n=6) control, group 2 (n=6) saline, group 3 (n=6) dexamethasone (2mg/kg/day intramuscularly [IM]), group 4 (n=6) ACTH analogue (0,4mg/kg/day IM), respectively...
May 7, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29746905/chronic-lead-exposure-induces-cochlear-oxidative-stress-and-potentiates-noise-induced-hearing-loss
#4
Samson Jamesdaniel, Rita Rosati, Judy Westrick, Douglas M Ruden
Acquired hearing loss is caused by complex interactions of multiple environmental risk factors, such as elevated levels of lead and noise, which are prevalent in urban communities. This study delineates the mechanism underlying lead-induced auditory dysfunction and its potential interaction with noise exposure. Young-adult C57BL/6 mice were exposed to: 1) control conditions; 2) 2 mM lead acetate in drinking water for 28 days; 3) 90 dB broadband noise 2 h/day for two weeks; and 4) both lead and noise...
May 7, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29743779/hearing-threshold-status-and-risk-estimate-of-hearing-impairment-among-administrative-workforce
#5
Joydeep Majumder, Ramanlal C Patel, Sanjay Kotadiya, Priyanka Shah
Background: Administrative workers working in quieter environment workplace are considered unaffected by noise-induced hearing loss (NIHL). Aim: To create a baseline data of the administrative workers so as to monitor them with prospective years of exposure with the hypothesis that workers working in the administrative jobs may not be affected by NIHL. Settings and Design: The study was conducted among men and women administrative workers working in an office in Ahmedabad city, India...
January 2018: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29735658/osmotic-stabilization-prevents-cochlear-synaptopathy-after-blast-trauma
#6
Jinkyung Kim, Anping Xia, Nicolas Grillet, Brian E Applegate, John S Oghalai
Traumatic noise causes hearing loss by damaging sensory hair cells and their auditory synapses. There are no treatments. Here, we investigated mice exposed to a blast wave approximating a roadside bomb. In vivo cochlear imaging revealed an increase in the volume of endolymph, the fluid within scala media, termed endolymphatic hydrops. Endolymphatic hydrops, hair cell loss, and cochlear synaptopathy were initiated by trauma to the mechanosensitive hair cell stereocilia and were K+ -dependent. Increasing the osmolality of the adjacent perilymph treated endolymphatic hydrops and prevented synaptopathy, but did not prevent hair cell loss...
May 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29733894/cochlear-hair-cell-regeneration-an-emerging-opportunity-to-cure-noise-induced-sensorineural-hearing-loss
#7
REVIEW
Ibrahima Youm, Wei Li
In mammals, cochlear hair cells have a pivotal role in transducing mechanical energy into electrical signals. Cochlear hair cells are sensitive to acoustic trauma, drug insults, aging, and environmental or genetic influences that can cause permanent hearing loss. Currently, much research is focusing on noise-induced sensorineural hearing loss (SNHL). Noise-induced SNHL is primarily caused by damage to hair cells of the cochlear sensory epithelium. Here, we summarize progress in restoring the sensory epithelium after SNHL resulting from noise exposure...
May 4, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29716271/supra-aural-transducer-related-artifact-contributes-to-overestimation-of-noise-induced-hearing-loss
#8
Ishan S Bhatt
This study compared the effects of supra-aural and insert receivers on the prevalence of noise-induced hearing loss (NIHL) in young adults. NIHL prevalence was found to be substantially higher when hearing thresholds were obtained with supra-aural compared to insert receivers on the same subjects. Real-ear sound pressure levels at 4000, 6000, and 8000 Hz were the major predictors of notched-audiograms obtained with supra-aural headphones. Distortion-product otoacoustic emissions were not significantly different between ears with and without notched-audiograms obtained with supra-aural headphones...
April 2018: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29712550/sound-pressure-levels-generated-at-risk-volume-steps-of-portable-listening-devices-types-of-smartphone-and-genres-of-music
#9
Gibbeum Kim, Woojae Han
BACKGROUND: The present study estimated the sound pressure levels of various music genres at the volume steps that contemporary smartphones deliver, because these levels put the listener at potential risk for hearing loss. METHODS: Using six different smartphones (Galaxy S6, Galaxy Note 3, iPhone 5S, iPhone 6, LG G2, and LG G3), the sound pressure levels for three genres of K-pop music (dance-pop, hip-hop, and pop-ballad) and a Billboard pop chart of assorted genres were measured through an earbud for the first risk volume that was at the risk sign proposed by the smartphones, as well as consecutive higher volumes using a sound level meter and artificial mastoid...
May 1, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29710132/association-of-behavior-with-noise-induced-hearing-loss-among-attendees-of-an-outdoor-music-festival-a-secondary-analysis-of-a-randomized-clinical-trial
#10
Véronique J C Kraaijenga, J J C M van Munster, G A van Zanten
Importance: To date, factors associated with noise-induced hearing loss at music festivals have not yet been analyzed in a single comprehensive data set. In addition, little is known about the hearing loss-associated behavior of music festival attendees. Objectives: To assess which factors are associated with the occurrence of a temporary threshold shift (TTS) after music exposure and to investigate the behavior of music festival attendees. Design, Setting, and Participants: This prospective post hoc analysis gathered data from a randomized, single-blind clinical trial conducted on September 5, 2015, at an outdoor music festival in Amsterdam, the Netherlands...
April 19, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29703094/headphone-listening-habits-hearing-thresholds-and-listening-levels-in-swedish-adolescents-with-severe-to-profound-hl-and-adolescents-with-normal-hearing
#11
Stephen E Widén, Claes Möller, Kim Kähäri
OBJECTIVE: Research has minimally focussed on the music listening habits and preferred sound volumes among adolescents with severe to profound congenital HL. Listening to music played at loud sound volumes and for a long duration of time could imply risks of worsening the HL. Therefore, it is important to investigate the listening habits in adolescents with HL. The aim of the present study was to describe the use of personal music devices, subjective estimated sound levels, measured sound levels, listening habits, and hearing symptoms in adolescents with severe to profound hearing loss compared with adolescents with normal hearing...
April 27, 2018: International Journal of Audiology
https://www.readbyqxmd.com/read/29681993/noise-exposure-and-auditory-thresholds-of-military-musicians-a-follow-up-study
#12
Reinhard Müller, Joachim Schneider
Background: Military musicians are working in a noisy environment with high sound exposure levels above the international standards. Aim of the current study is to find out, whether they develop the expected hearing impairments. Adherence to the regulations for prevention in musicians is more difficult than in other occupational fields. Methods: In an interval of 13.3 years, 36 out of 58 male military musicians of a German army music corps were subjected twice to an audiometric audit...
2018: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/29677689/neural-and-behavioral-changes-after-the-use-of-hearing-aids
#13
Hanin Karawani, Kimberly A Jenkins, Samira Anderson
OBJECTIVE: Individuals with age-related hearing loss (ARHL) can restore some loss of the auditory function with the use of hearing aids (HAs). However, what remains unknown are the physiological mechanisms that underlie how the brain changes with exposure to amplified sounds though the use of HAs. We aimed to examine behavioral and physiological changes induced by HAs. METHODS: Thirty-five older-adults with moderate ARHL with no history of hearing aid use were fit with HAs tested in aided and unaided conditions, and divided into experimental and control groups...
April 7, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29676294/noise-exposure-and-hearing-loss-in-classical-orchestra-musicians-a-five-year-follow-up
#14
Alberto Behar, Marshall Chasin, Steve Mosher, Mohammad Abdoli-Eramaki, Frank A Russo
Introduction: This study is a follow-up to prior research from our group that attempts to relate noise exposure and hearing thresholds in active performing musicians of the National Ballet of Canada Orchestra. Materials and Methods: Exposures obtained in early 2010 were compared to exposures obtained in early 2017 (the present study). In addition, audiometric thresholds obtained in early 2012 were compared to thresholds obtained in early 2017 (the present study)...
March 2018: Noise & Health
https://www.readbyqxmd.com/read/29675997/hearing-vulnerability-after-noise-exposure-in-a-mouse-model-of-reactive-oxygen-species-overproduction
#15
Shigefumi Morioka, Hirofumi Sakaguchi, Taro Yamaguchi, Yuzuru Ninoyu, Hiroaki Mohri, Takashi Nakamura, Yasuo Hisa, Kiyokazu Ogita, Naoaki Saito, Takehiko Ueyama
Previous studies have convincingly argued that reactive oxygen species (ROS) contribute to the development of several major types of sensorineural hearing loss, such as noise-induced hearing loss (NIHL), drug-induced hearing loss, and age-related hearing loss. However, the underlying molecular mechanisms induced by ROS in these pathologies remain unclear. To resolve this issue, we established an in vivo model of ROS overproduction by generating a transgenic (TG) mouse line expressing the human NADPH oxidase 4 (NOX4, NOX4-TG mice), which is a constitutively active ROS-producing enzyme that does not require stimulation or an activator...
April 20, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29673641/a-novel-nanoparticle-delivery-system-for-targeted-therapy-of-noise-induced-hearing-loss
#16
Mohammad N Kayyali, Julian R A Wooltorton, Andrew J Ramsey, Mei Lin, Tiffany N Chao, Andrew Tsourkas, Bert W O'Malley, Daqing Li
Hearing loss is the most prevalent sensory disability worldwide and may be caused by age, drugs or exposure to excessive noise. We have previously developed a minimally-invasive nanohydrogel drug delivery system that successfully delivers nanoparticles into the inner ear. We have substantially extended this technique by functionalizing the nanoparticles and introducing a targeting peptide which recognizes prestin, a transmembrane electromotile protein uniquely expressed in outer hair cells (OHCs) of the inner ear...
April 16, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29668848/adult-onset-hearing-impairment-induces-layer-specific-cortical-reorganization-evidence-of-crossmodal-plasticity-and-central-gain-enhancement
#17
Ashley L Schormans, Marei Typlt, Brian L Allman
Adult-onset hearing impairment can lead to hyperactivity in the auditory pathway (i.e., central gain enhancement) as well as increased cortical responsiveness to nonauditory stimuli (i.e., crossmodal plasticity). However, it remained unclear to what extent hearing loss-induced hyperactivity is relayed beyond the auditory cortex, and thus, whether central gain enhancement competes or coexists with crossmodal plasticity throughout the distinct layers of the audiovisual cortex. To that end, we investigated the effects of partial hearing loss on laminar processing in the auditory, visual and audiovisual cortices of adult rats using extracellular electrophysiological recordings performed 2 weeks after loud noise exposure...
April 13, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29662441/characterization-of-hair-cell-like-cells-converted-from-supporting-cells-after-notch-inhibition-in-cultures-of-the-organ-of-corti-from-neonatal-gerbils
#18
Yi Li, Shuping Jia, Huizhan Liu, Tomoko Tateya, Weiwei Guo, Shiming Yang, Kirk W Beisel, David Z Z He
The senses of hearing and balance depend upon hair cells, the sensory receptors of the inner ear. Hair cells transduce mechanical stimuli into electrical activity. Loss of hair cells as a result of aging or exposure to noise and ototoxic drugs is the major cause of noncongenital hearing and balance deficits. In the ear of non-mammals, lost hair cells can spontaneously be replaced by production of new hair cells from conversion of supporting cells. Although supporting cells in adult mammals have lost that capability, neonatal supporting cells are able to convert to hair cells after inhibition of Notch signaling...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29649050/temporal-bone-histopathology-in-cockayne-syndrome
#19
Ophir Handzel, Joseph B Nadol
: Cockayne syndrome (CS) is a rare autosomal recessive syndrome resulting in defective DNA repair. Its features include cachectic dwarfism, hearing loss, skin hypersensitivity to sunlight, premature aging, and dementia. Presented is a right temporal bone of a patient who died at the age of 29 years. The clinical course was compatible with type 1 CS, the classical form. Homozygous missense variant in the ERCC6 gene (Excision Repair Cross-Complementation group 6) was found, compatible with CS complementation group B...
April 11, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29618634/mice-harbouring-an-oculodentodigital-dysplasia-linked-cx43-g60s-mutation-have-severe-hearing-loss
#20
Julia M Abitbol, John J Kelly, Kevin J Barr, Brian L Allman, Dale W Laird
Given the importance of connexin43 (Cx43) function in the central nervous system and sensory organ processing we proposed that it would also be crucial in auditory function. To that end, hearing was examined in two mouse models of oculodentodigital dysplasia that globally express GJA1 (Cx43) mutations resulting in mild or severe loss of Cx43 function. Although Cx43I130T/+ mutant mice with ∼50% Cx43 channel function did not have any hearing loss, Cx43G60S/+ mutant mice with ∼20% Cx43 channel function had severe hearing loss...
April 3, 2018: Journal of Cell Science
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