keyword
MENU ▼
Read by QxMD icon Read
search

Rfx

keyword
https://www.readbyqxmd.com/read/27933401/improvement-of-abnormal-vaginal-flora-in-ugandan-women-by-self-testing-and-short-use-of-intravaginal-antimicrobials
#1
G Donders, G Bellen, F Donders, J Pinget, I Vandevelde, T Michiels, J Byamughisa
The vaginal composition of African women is more often lactobacillus-deficient compared to that of women from other areas around the world. Lactobacillus-deficient microflora is a known risk factor for serious health problems, such as preterm birth, cervix cancer, and entrapment of human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs). The aim of this study was to assess the effect of local vaginal antibiotic or antiseptic treatment on abnormal vaginal flora (AVF), aerobic vaginitis (AV), and bacterial vaginosis (BV) among women in rural, semi-urban, and urban areas in Uganda, as compared to placebo...
December 8, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27451412/ciliary-dyslexia-candidate-genes-dyx1c1-and-dcdc2-are-regulated-by-regulatory-factor-x-rfx-transcription-factors-through-x-box-promoter-motifs
#2
Kristiina Tammimies, Andrea Bieder, Gilbert Lauter, Debora Sugiaman-Trapman, Rachel Torchet, Marie-Estelle Hokkanen, Jan Burghoorn, Eero Castrén, Juha Kere, Isabel Tapia-Páez, Peter Swoboda
DYX1C1, DCDC2, and KIAA0319 are three of the most replicated dyslexia candidate genes (DCGs). Recently, these DCGs were implicated in functions at the cilium. Here, we investigate the regulation of these DCGs by Regulatory Factor X transcription factors (RFX TFs), a gene family known for transcriptionally regulating ciliary genes. We identify conserved X-box motifs in the promoter regions of DYX1C1, DCDC2, and KIAA0319 and demonstrate their functionality, as well as the ability to recruit RFX TFs using reporter gene and electrophoretic mobility shift assays...
October 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27368343/validated-uplc-and-tlc-densitometry-stability-indicating-methods-for-the-determination-of-rafoxanide-in-the-presence-of-its-degradation-products
#3
Ahmed S Saad, Abdallah M Hamdy, Fathy M Salama, Mohamed Abdelkawy
Two sensitive and accurate stability-indicating chromatographic methods were developed and validated for the determination of rafoxanide (RFX). Degradation products were identified by mass spectrometry and IR spectroscopy. The first is ultra-performance liquid chromatography method where separation was performed using acetonitrile:0.005 M potassium dihydrogen orthophosphate (pH 3.5) in a ratio of 80:20 by volume as a mobile phase using a Hypersil GOLD™ C8 column 1.9 mm (50 × 2.1 mm), UV detection was adjusted at 220 nm and the flow rate was 0...
July 1, 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27203329/internal-transport-barrier-broadening-through-subdominant-mode-stabilization-in-reversed-field-pinch-plasmas
#4
R Lorenzini, F Auriemma, A Fassina, E Martines, D Terranova, F Sattin
The reversed field pinch (RFP) device RFX-mod features strong internal transport barriers when the plasma accesses states with a single dominant helicity. Such transport barriers enclose a hot helical region with high confinement whose amplitude may vary from a tiny one to an amplitude encompassing an appreciable fraction of the available volume. The transition from narrow to wide thermal structures has been ascribed so far to the transport reduction that occurs when the dominant mode separatrix, which is a preferred location for the onset of stochastic field lines, disappears...
May 6, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/26932051/steady-state-thermal-hydraulic-analyses-of-the-mitica-cooling-circuits
#5
M Zaupa, E Sartori, M Dalla Palma, F Fellin, D Marcuzzi, M Pavei, A Rizzolo
Megavolt ITER Injector Concept Advancement is the full scale prototype of the heating and current drive neutral beam injectors for ITER, to be built at Consorzio RFX (Padova). The engineering design of its components is challenging: the total heat loads they will be subjected to (expected between 2 and 19 MW), the high heat fluxes (up to 20 MW/m(2)), and the beam pulse duration up to 1 h, set demanding requirements for reliable active cooling circuits. In support of the design, the thermo-hydraulic behavior of each cooling circuit under steady state condition has been investigated by using one-dimensional models...
February 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/26932048/first-experiments-with-the-negative-ion-source-nio1
#6
M Cavenago, G Serianni, M De Muri, P Agostinetti, V Antoni, C Baltador, M Barbisan, L Baseggio, M Bigi, V Cervaro, F Degli Agostini, E Fagotti, T Kulevoy, N Ippolito, B Laterza, A Minarello, M Maniero, R Pasqualotto, S Petrenko, M Poggi, D Ravarotto, M Recchia, E Sartori, M Sattin, P Sonato, F Taccogna, V Variale, P Veltri, B Zaniol, L Zanotto, S Zucchetti
Neutral Beam Injectors (NBIs), which need to be strongly optimized in the perspective of DEMO reactor, request a thorough understanding of the negative ion source used and of the multi-beamlet optics. A relatively compact radio frequency (rf) ion source, named NIO1 (Negative Ion Optimization 1), with 9 beam apertures for a total H(-) current of 130 mA, 60 kV acceleration voltage, was installed at Consorzio RFX, including a high voltage deck and an X-ray shield, to provide a test bench for source optimizations for activities in support to the ITER NBI test facility...
February 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/26932047/first-hydrogen-operation-of-nio1-characterization-of-the-source-plasma-by-means-of-an-optical-emission-spectroscopy-diagnostic
#7
M Barbisan, C Baltador, B Zaniol, M Cavenago, U Fantz, R Pasqualotto, G Serianni, L Vialetto, D Wünderlich
NIO1 (Negative Ion Optimization 1) is a compact and flexible radio frequency H(-) ion source, developed by Consorzio RFX and INFN-LNL. The aim of the experimentation on NIO1 is the optimization of both the production of negative ions and their extraction and beam optics. In the initial phase of its commissioning, NIO1 was operated with nitrogen, but now the source is regularly operated also with hydrogen. To evaluate the source performances, an optical emission spectroscopy diagnostic was installed. The system includes a low resolution spectrometer in the spectral range of 300-850 nm and a high resolution (50 pm) one, to study, respectively, the atomic and the molecular emissions in the visible range...
February 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/26932033/ion-collector-design-for-an-energy-recovery-test-proposal-with-the-negative-ion-source-nio1
#8
V Variale, M Cavenago, P Agostinetti, P Sonato, L Zanotto
Commercial viability of thermonuclear fusion power plants depends also on minimizing the recirculation power used to operate the reactor. The neutral beam injector (NBI) remains one of the most important method for plasma heating and control. For the future fusion power plant project DEMO, a NBI wall plug efficiency at least of 0.45 is required, while efficiency of present NBI project is about 0.25. The D(-) beam from a negative ion source is partially neutralized by a gas cell, which leaves more than 40% of energy in residual beams (D(-) and D(+)), so that an ion beam energy recovery system can significantly contribute to optimize efficiency...
February 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/26880325/ciliary-transcription-factors-in-cancer-how-understanding-ciliogenesis-can-promote-the-detection-and-prognosis-of-cancer-types
#9
COMMENT
Peter Walentek
Cilia play a plethora of roles in normal development and homeostasis as well as in disease. Their involvement in cell signalling processes and ability to inhibit cell cycle progression make them especially interesting subjects of investigation in the context of tumour formation and malignancy. Several key transcription factors regulate the transcriptional programme in cilia formation and some of these, eg RFX factors and FOXJ1, are implicated in cancer formation. Furthermore, RFX factors and FOXJ1 are increasingly being explored for their potential as markers to diagnose, classify and predict the outcome of cancers in patients, including recent work published in this journal on aggressive ependymoma and choroid plexus tumours...
May 2016: Journal of Pathology
https://www.readbyqxmd.com/read/26871568/degradation-promoter-recruitment-and-transactivation-mediated-by-the-extreme-n-terminus-of-mhc-class-ii-transactivator-ciita-isoform-iii
#10
Yves B Beaulieu, Jorge A Leon Machado, Sylvain Ethier, Luc Gaudreau, Viktor Steimle
Multiple relationships between ubiquitin-proteasome mediated protein turnover and transcriptional activation have been well documented, but the underlying mechanisms are still poorly understood. One way to induce degradation is via ubiquitination of the N-terminal α-amino group of proteins. The major histocompatibility complex (MHC) class II transactivator CIITA is the master regulator of MHC class II gene expression and we found earlier that CIITA is a short-lived protein. Using stable and transient transfections of different CIITA constructs into HEK-293 and HeLa cell lines, we show here that the extreme N-terminal end of CIITA isoform III induces both rapid degradation and transactivation...
2016: PloS One
https://www.readbyqxmd.com/read/26853561/transcription-factor-rfx2-is-a-key-regulator-of-mouse-spermiogenesis
#11
Yujian Wu, Xiangjing Hu, Zhen Li, Min Wang, Sisi Li, Xiuxia Wang, Xiwen Lin, Shangying Liao, Zhuqiang Zhang, Xue Feng, Si Wang, Xiuhong Cui, Yanling Wang, Fei Gao, Rex A Hess, Chunsheng Han
The regulatory factor X (RFX) family of transcription factors is crucial for ciliogenesis throughout evolution. In mice, Rfx1-4 are highly expressed in the testis where flagellated sperm are produced, but the functions of these factors in spermatogenesis remain unknown. Here, we report the production and characterization of the Rfx2 knockout mice. The male knockout mice were sterile due to the arrest of spermatogenesis at an early round spermatid step. The Rfx2-null round spermatids detached from the seminiferous tubules, forming large multinucleated giant cells that underwent apoptosis...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26764484/antibiotic-and-antiinflammatory-therapy-transiently-reduces-inflammation-and-hypercoagulation-in-acutely-siv-infected-pigtailed-macaques
#12
Ivona Pandrea, Cuiling Xu, Jennifer L Stock, Daniel N Frank, Dongzhu Ma, Benjamin B Policicchio, Tianyu He, Jan Kristoff, Elaine Cornell, George S Haret-Richter, Anita Trichel, Ruy M Ribeiro, Russell Tracy, Cara Wilson, Alan L Landay, Cristian Apetrei
Increased chronic immune activation and inflammation are hallmarks of HIV/SIV infection and are highly correlated with progression to AIDS and development of non-AIDS comorbidities, such as hypercoagulability and cardiovascular disease. Intestinal dysfunction resulting in microbial translocation has been proposed as a lead cause of systemic immune activation and hypercoagulability in HIV/SIV infection. Our goal was to assess the biological and clinical impact of a therapeutic strategy designed to reduce microbial translocation through reduction of the microbial content of the intestine (Rifaximin-RFX) and of gut inflammation (Sulfasalazine-SFZ)...
January 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/26469318/rfx-transcription-factors-are-essential-for-hearing-in-mice
#13
COMPARATIVE STUDY
Ran Elkon, Beatrice Milon, Laura Morrison, Manan Shah, Sarath Vijayakumar, Manoj Racherla, Carmen C Leitch, Lorna Silipino, Shadan Hadi, Michèle Weiss-Gayet, Emmanuèle Barras, Christoph D Schmid, Aouatef Ait-Lounis, Ashley Barnes, Yang Song, David J Eisenman, Efrat Eliyahu, Gregory I Frolenkov, Scott E Strome, Bénédicte Durand, Norann A Zaghloul, Sherri M Jones, Walter Reith, Ronna Hertzano
Sensorineural hearing loss is a common and currently irreversible disorder, because mammalian hair cells (HCs) do not regenerate and current stem cell and gene delivery protocols result only in immature HC-like cells. Importantly, although the transcriptional regulators of embryonic HC development have been described, little is known about the postnatal regulators of maturating HCs. Here we apply a cell type-specific functional genomic analysis to the transcriptomes of auditory and vestibular sensory epithelia from early postnatal mice...
October 15, 2015: Nature Communications
https://www.readbyqxmd.com/read/26083275/the-carboxyl-terminal-region-is-not-essential-for-secreted-and-functional-levels-of-coagulation-factor-x
#14
A Branchini, M Baroni, F Burini, F Puzzo, F Nicolosi, R Mari, D Gemmati, F Bernardi, M Pinotti
BACKGROUND: The homologous coagulation factor X (FX), VII (FVII), IX (FIX) and protein C (PC) display striking differences in the carboxyl-terminus, with that of FX being the most extended. This region is essential for FVII, FIX and PC secretion. OBJECTIVES: To provide experimental evidence for the role of the FX carboxyl-terminus. METHODS: Recombinant FX (rFX) variants were expressed in multiple eukaryotic cell systems. Protein and activity levels were evaluated by ELISA, coagulant and amidolytic assays...
August 2015: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/26065027/qrfxfreeze-queryable-compressor-for-rfx
#15
Radha Senthilkumar, Gomathi Nandagopal, Daphne Ronald
The verbose nature of XML has been mulled over again and again and many compression techniques for XML data have been excogitated over the years. Some of the techniques incorporate support for querying the XML database in its compressed format while others have to be decompressed before they can be queried. XML compression in which querying is directly supported instantaneously with no compromise over time is forced to compromise over space. In this paper, we propose the compressor, QRFXFreeze, which not only reduces the space of storage but also supports efficient querying...
2015: TheScientificWorldJournal
https://www.readbyqxmd.com/read/25979195/identification-of-therapeutic-targets-for-childhood-severe-asthmatics-with-dna-microarray
#16
Y Wu, J-F Zhang, T Xu, L Xu, J Qiao, F Liu, H Shan, X Jiang
BACKGROUND: In this study, we aimed to discover potential gene targets for treating childhood asthmatics. METHODS: With the microarray data downloaded from Gene Expression Omnibus (GEO) database, we explored the common differentially expressed genes (DEGs) in children with severe asthma and mild asthma (SA vs. MA) or healthy controls (SA vs. HC). Then we performed hierarchical clustering, function and pathway enrichment analysis for the common DEGs. RESULTS: A total of 81 genes were identified to be differentially expressed in SA vs...
January 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/25909417/a-pilot-single-institution-predictive-model-to-guide-rib-fracture-management-in-elderly-patients
#17
Katherine W Gonzalez, Mira H Ghneim, Francis Kang, Daniel C Jupiter, Matthew L Davis, Justin L Regner
BACKGROUND: Rib fractures (RFx) remain the most prevalent injury in an elderly population that will increase from 40 to 81 million for the next 30 years. We sought to create an accurate cost-effective algorithm to triage elderly patients with RFx that accounted for both frailty and trauma burden. METHODS: Retrospective analysis evaluated 400 patients older than 55 years with RFx admitted to a level 1 trauma center from 2007 to 2012. Comorbidities included chronic obstructive pulmonary disease, congestive heart failure, tobacco use, obesity, and nutrition and functional status...
May 2015: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/25908789/a-new-transcription-factor-for-mitosis-in-schizosaccharomyces-pombe-the-rfx-transcription-factor-sak1-works-with-forkhead-factors-to-regulate-mitotic-expression
#18
Angad Garg, Bruce Futcher, Janet Leatherwood
Mitotic genes are one of the most strongly oscillating groups of genes in the eukaryotic cell cycle. Understanding the regulation of mitotic gene expression is a key issue in cell cycle control but is poorly understood in most organisms. Here, we find a new mitotic transcription factor, Sak1, in the fission yeast Schizosaccharomyces pombe. Sak1 belongs to the RFX family of transcription factors, which have not previously been connected to cell cycle control. Sak1 binds upstream of mitotic genes in close proximity to Fkh2, a forkhead transcription factor previously implicated in regulation of mitotic genes...
August 18, 2015: Nucleic Acids Research
https://www.readbyqxmd.com/read/25740990/kaposi-s-sarcoma-associated-herpesvirus-latency-associated-nuclear-antigen-inhibits-major-histocompatibility-complex-class-ii-expression-by-disrupting-enhanceosome-assembly-through-binding-with-the-regulatory-factor-x-complex
#19
Suhani Thakker, Pravinkumar Purushothaman, Namrata Gupta, Shanthan Challa, Qiliang Cai, Subhash C Verma
UNLABELLED: Major histocompatibility complex class II (MHC-II) molecules play a central role in adaptive antiviral immunity by presenting viral peptides to CD4(+) T cells. Due to their key role in adaptive immunity, many viruses, including Kaposi's sarcoma-associated herpesvirus (KSHV), have evolved multiple strategies to inhibit the MHC-II antigen presentation pathway. The expression of MHC-II, which is controlled mainly at the level of transcription, is strictly dependent upon the binding of the class II transactivator (CIITA) to the highly conserved promoters of all MHC-II genes...
May 2015: Journal of Virology
https://www.readbyqxmd.com/read/25669320/synthesis-and-evaluation-of-anticancer-activity-of-5-ylidene-4-aminothiazol-2-5h-one-derivatives
#20
Danylo Kaminskyy, Ivanna Subtel'na, Borys Zimenkovsky, Olexandr Karpenko, Andrzej Gzella, Roman Lesyk
The synthesis and antitumor activity screening of 4-aminothiazol-2(5H)-one derivatives were performed. The absence of possible 4-amino-imino tautomerism of thiazolidinones-2 has been confirmed based on the study of the molecule structures. The existence of the alone amino-form was confirmed. An anticancer activity screening was performed within the Developmental Therapeutics Program (National Cancer Institute/NIH, USA). Tested compounds possess low to moderate anticancer activity (average values - 60 cancer cell lines assay) with significant selective action on certain cancer cell lines (CCRF-CEM and RPMI-8226/leukemia, U251/CNS cancer, RFX 393/renal cancer, OVCAR/ovarian cancer etc...
2015: Medicinal Chemistry
keyword
keyword
55293
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"