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https://www.readbyqxmd.com/read/28448971/pre-esrd-dementia-and-post-esrd-mortality-in-a-large-cohort-of-incident-dialysis-patients
#1
Miklos Z Molnar, Keiichi Sumida, Abduzhappar Gaipov, Praveen K Potukuchi, Tibor Fülöp, Kiran Joglekar, Jun Ling Lu, Elani Streja, Kamyar Kalantar-Zadeh, Csaba P Kovesdy
BACKGROUND: Conservative management may be a desirable option for elderly, fragile, or demented patients who reach end-stage renal disease (ESRD), yet some patients with dementia are placed on renal replacement therapy nonetheless. METHODS: From a nationwide cohort of 45,076 US veterans who transitioned to ESRD over 4 contemporary years (October 1, 2007 to September 30, 2011), we identified 1,336 (3.0%) patients with International Classification of Diseases, Ninth Revision, Clinical Modification code-based dementia diagnosis during the prelude (predialysis) period...
April 28, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28448866/function-of-microrna-143-in-different-signal-pathways-in-cancer-new-insights-into-cancer-therapy
#2
REVIEW
Leila Karimi, Behzad Mansoori, Dariush Shanebandi, Ali Mohammadi, Mahyar Aghapour, Behzad Baradaran
MicroRNAs (miRNAs) are small non-coding RNAs which participate in the post-transcriptional regulation of gene expression. They play important roles in cellular events such as growth and differentiation. Deregulation of miRNAs is frequently evident in human cancers where their aberrant expression is associated with uncontrolled proliferation, metastasis, impaired cell cycle and DNA damage response. The miRNAs are important in cancer as ∼50% of miRNA genes are located in cancer-associated regions such as fragile sites of genome...
April 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28447077/evidence-europe-2017-london-uk-february-22-23-2017
#3
A Kibble
As the political backdrop changes in both the U.S. and Europe, volatility in the pharma industry is beginning to be felt as the sector becomes sensitive to the uncertainty. U.S. President Trump has stated he will pursue an agenda against high U.S. drug prices and is expected to seek to repeal the Affordable Care Act, while in Europe, Brexit casts further unknowns in regulatory authorization procedures, trade and external reference pricing. With these factors in mind, Terrapin's Evidence Europe meeting provided for a very topical discussion on the use of evidence to define and communicate value in healthcare...
March 2017: Drugs of Today
https://www.readbyqxmd.com/read/28445142/potential-biomarkers-of-dna-replication-stress-in-cancer
#4
Liqun Ren, Long Chen, Wei Wu, Lorenza Garribba, Huanna Tian, Zihui Liu, Ivan Vogel, Chunhui Li, Ian D Hickson, Ying Liu
Oncogene activation is an established driver of tumorigenesis. An apparently inevitable consequence of oncogene activation is the generation of DNA replication stress (RS), a feature common to most cancer cells. RS, in turn, is a causal factor in the development of chromosome instability (CIN), a near universal feature of solid tumors. It is likely that CIN and RS are mutually reinforcing drivers that not only accelerate tumorigenesis, but also permit cancer cells to adapt to diverse and hostile environments...
April 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28444183/calcium-dysregulation-and-cdk5-atm-pathway-involved-in-a-mouse-model-of-fragile-x-associated-tremor-ataxia-syndrome
#5
Gaëlle Robin, José R López, Glenda M Espinal, Susan Hulsizer, Paul J Hagerman, Isaac N Pessah
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurological disorder that affects premutation carriers with 55-200 CGG-expansion repeats (preCGG) in FMR1, presenting with early alterations in neuronal network formation and function that precede neurodegeneration. Whether intranuclear inclusions containing DNA damage response (DDR) proteins, are causally linked to abnormal synaptic function, neuronal growth and survival are unknown. In a mouse that harbors a premutation CGG expansion (preCGG), cortical and hippocampal FMRP expression is moderately reduced from birth through adulthood, with greater FMRP reductions in the soma than in the neurite, despite several-fold elevation of Fmr1 mRNA levels...
April 21, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28444047/health-regionalization-in-amazonas-progress-and-challenges
#6
Luiza Garnelo, Amandia Braga Lima Sousa, Clayton de Oliveira da Silva
This paper analyses the health services regionalization process in the State of Amazonas through a case study covering the health sub-region Manaus Surroundings. This is a qualitative, descriptive and analytical research, which data were collected using interviews, documents and Internet reviews, oriented by the guiding concept of health regionalization. Study findings revealed a social setting dominated by asymmetry, verticality, competitiveness and fragile multilateral relations among municipalities, associated to a bureaucratic profile of local institutions operating in the region under study...
April 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28444041/primary-health-care-and-the-coordination-of-care-in-health-regions-managers-and-users-perspective
#7
Aylene Bousquat, Ligia Giovanella, Estela Márcia Saraiva Campos, Patty Fidelis de Almeida, Cleide Lavieri Martins, Paulo Henrique Dos Santos Mota, Maria Helena Magalhães de Mendonça, Maria Guadalupe Medina, Ana Luiza d'Ávila Viana, Márcia Cristina Rodrigues Fausto, Daniel Baffini de Paula
This paper aims to analyze the healthcare coordination by Primary Health Care (PHC), with the backdrop of building a Health Care Network (RAS) in a region in the state of São Paulo, Brazil. We conducted a case study with qualitative and quantitative approaches, proceeding to the triangulation of data between the perception of managers and experience of users. We drew analysis realms and variables from the three pillars of healthcare coordination - informational, clinical and administrative/organizational. Stroke was the tracer event chosen and therapeutic itineraries were conducted with users and questionnaires applied to the managers...
April 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28442996/structural-characteristics-of-simple-rna-repeats-associated-with-disease-and-their-deleterious-protein-interactions
#8
REVIEW
Adam Ciesiolka, Magdalena Jazurek, Karolina Drazkowska, Wlodzimierz J Krzyzosiak
Short Tandem Repeats (STRs) are frequent entities in many transcripts, however, in some cases, pathological events occur when a critical repeat length is reached. This phenomenon is observed in various neurological disorders, such as myotonic dystrophy type 1 (DM1), fragile X-associated tremor/ataxia syndrome, C9orf72-related amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD), and polyglutamine diseases, such as Huntington's disease (HD) and spinocerebellar ataxias (SCA). The pathological effects of these repeats are triggered by mutant RNA transcripts and/or encoded mutant proteins, which depend on the localization of the expanded repeats in non-coding or coding regions...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28442297/vertebral-and-femoral-bone-mineral-density-and-bone-strength-in-prostate-cancer-patients-assessed-in-phantomless-pet-ct-examinations
#9
Benedikt J Schwaiger, David L Kopperdahl, Lorenzo Nardo, Luca Facchetti, Alexandra S Gersing, Jan Neumann, Kwang J Lee, Tony M Keaveny, Thomas M Link
PURPOSE: Bone fracture risk assessed ancillary to positron emission tomography with computed tomography co-registration (PET/CT) could provide substantial clinical value to oncology patients with elevated fracture risk without introducing additional radiation dose. The purpose of our study was to investigate the feasibility of obtaining valid measurements of bone mineral density (BMD) and finite element analysis-derived bone strength of the hip and spine using PET/CT examinations of prostate cancer patients by comparing against values obtained using routine multidetector-row computed tomography (MDCT) scans-as validated in previous studies-as a reference standard...
April 22, 2017: Bone
https://www.readbyqxmd.com/read/28442243/abnormal-neural-precursor-cell-regulation-in-the-early-postnatal-fragile-x-mouse-hippocampus
#10
Mary Sourial, Laurie C Doering
The regulation of neural precursor cells (NPCs) is indispensable for a properly functioning brain. Abnormalities in NPC proliferation, differentiation, survival, or integration have been linked to various neurological diseases including Fragile X syndrome. Yet, no studies have examined NPCs from the early postnatal Fragile X mouse hippocampus despite the importance of this developmental time point, which marks the highest expression level of FMRP, the protein missing in Fragile X, in the rodent hippocampus and is when hippocampal NPCs have migrated to the dentate gyrus (DG) to give rise to lifelong neurogenesis...
April 22, 2017: Brain Research
https://www.readbyqxmd.com/read/28442028/revisiting-the-ability-of-australian-primary-healthcare-services-to-respond-to-health-inequity
#11
Toby Freeman, Fran Baum, Angela Lawless, Sara Javanparast, Gwyn Jolley, Ronald Labonté, Michael Bentley, John Boffa, David Sanders
Equity of access and reducing health inequities are key objectives of comprehensive primary health care. However, the supports required to target equity are fragile and vulnerable to changes in the fiscal and political environment. Six Australian primary healthcare services, five in South Australia and one in the Northern Territory, were followed over 5 years (2009-2013) of considerable change. Fifty-five interviews were conducted with service managers, staff, regional health executives and health department representatives in 2013 to examine how the changes had affected their practice regarding equity of access and responding to health inequity...
September 2016: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/28441561/neural-circuits-reduced-inhibition-in-fragile-x-syndrome
#12
Randall M Golovin, Kendal Broadie
The Drosophila Fragile X Syndrome model has long generated insights into this devastating neurological disease state. A recent study of olfactory neural circuitry shows that decreased lateral inhibition onto projection neurons relaying sensory input into higher brain centers causes impaired behavior.
April 24, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28441007/rough-structure-of-electrodeposition-as-a-template-for-an-ultra-robust-self-cleaning-surface
#13
Yongquan Qing, Chuanbo Hu, Chuanning Yang, Kai An, Fawei Tang, Junyan Tan, Changsheng Liu
Superhydrophobic surfaces with self-cleaning properties have developed, based on roughness on the micro/nanometer scales and low-energy surfaces. However, such surfaces are fragile and stop functioning when exposed to oil. Addressing these challenges, here we show an ultra-robust self-cleaning surface fabricated by a process of metal electrodeposition of a rough structure that is subsequently coated with a fluorinated metal-oxide nanoparticles. Scanning electron microscopy, Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy and X-ray diffraction were employed to characterize the surfaces...
April 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28440761/recommendations-on-the-effect-of-antidiabetic-drugs-in-bone
#14
Pedro Rozas-Moreno, Rebeca Reyes-García, Esteban Jódar-Gimeno, Mariela Varsavsky, Inés Luque-Fernández, María Cortés-Berdonces, Manuel Muñoz-Torres
OBJECTIVE: To provide recommendations on the effect of antidiabetic drugs on bone fragility to help select the most adequate antidiabetic treatment, especially in diabetic patients with high risk of fracture. PARTICIPANTS: Members of the Bone Metabolism Working Group of the Spanish Society of Endocrinology. METHODS: The GRADE system (Grading of Recommendations, Assessment, Development, and Evaluation) was used to establish both the strength of recommendations and the quality of evidence...
March 2017: Endocrinol Diabetes Nutr
https://www.readbyqxmd.com/read/28439265/bacterial-and-fungal-community-structures-in-loess-plateau-grasslands-with-different-grazing-intensities
#15
Huhe, Xianjiang Chen, Fujiang Hou, Yanpei Wu, Yunxiang Cheng
The Loess Plateau of China is one of the most fragile ecosystems worldwide; thus, human production activities need to be conducted very cautiously. In this study, MiSeq high-throughput sequencing was applied to assess the relationship between bacterial and fungal community structures and changes in vegetation and soil physical and chemical properties induced by grazing, in four grasslands with different levels of grazing intensity (0, 2.67, 5.33, and 8.67 sheep/ha) in the semiarid region of the Loess Plateau...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28439143/dynamics-of-urban-informal-labor-supply-in-the-united-states
#16
Samara R Gunter
OBJECTIVE: This study provides the first panel data estimates of informal work in the US and explores relationships between informal- and regular-sector participation among urban parents of young children. METHODS: I examine determinants of informal-sector participation in five waves of data from the Fragile Families and Child Wellbeing Study using probit, pooled Tobit, and fixed effects OLS models. RESULTS: Approximately 53 percent of urban fathers and 32 percent of urban mothers with young children pursue informal work over a nine-year period...
March 2017: Social Science Quarterly
https://www.readbyqxmd.com/read/28439053/-calcium-and-bone-metabolism-across-women-s-life-stages-bone-metabolism-of-women-in-primary-amenorrhea
#17
Tsuyoshi Higuchi
For development of the bone during adolescence, the increased estrogen plays an important role especially in young women as well as GH/IGF-Ⅰ system. Although primary amenorrhea can be caused by various pathological factors, almost of cases have a dysfunction of estrogen secretory systems. For Turner syndrome, which is well-known disease with primary amenorrhea,it is generally recommended that the estrogen therapy is started at adolescence and gradually increased up to adult dose level. Recently studies about the adequate dose of estrogen and the adequate age of adult dose in Turner syndrome revealed that intervention with adult dose of estrogen is required as soon as possible for gaining better bone mineral...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28437932/electrifying-catheters-with-light
#18
Martin Pekař, Jeannet van Rens, Martin B van der Mark
Smart minimally invasive devices face a connectivity challenge. An example is found in intracardiac echocardiography where the signal transmission and supply of power at the distal end require many thin and fragile wires in order to keep the catheter slim and flexible. We have built a fully functional bench-top prototype to demonstrate that electrical wires may be replaced by optical fibers. The prototype is immediately scalable to catheter dimensions. The absence of conductors will provide intrinsic galvanic isolation as well as radio frequency (RF) and magnetic resonance imaging (MRI) compatibility...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437277/the-fragile-balance-of-community-based-health-care-one-community-s-united-response-when-the-hiv-aids-primary-care-safety-net-failed
#19
Matthew Fifolt, D Scott Batey, James L Raper, Jane E Mobley, Lisa C McCormick
No abstract text is available yet for this article.
April 20, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28436599/metformin-as-targeted-treatment-in-fragile-x-syndrome
#20
Angel Belle C Dy, Flora Tassone, Marwa Eldeeb, María J Salcedo-Arellano, Nicole Tartaglia, Randi Hagerman
Individuals with Fragile X Syndrome (FXS) may be affected by several comorbid conditions, both behavioral and medical. Growth findings suggest that they are at an increased risk for obesity and overeating. The Prader-Willi phenotype (PWP) of FXS occurs in less than 10% of patients but it is associated with severe hyperphagia, lack of satiation and morbid obesity. Metformin is a drug used in individuals with high risk for diabetes type 2, obesity or impaired glucose tolerance. It has had a strong safety profile in children and adults with type 2 diabetes and obesity...
April 24, 2017: Clinical Genetics
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