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https://www.readbyqxmd.com/read/28806009/regional-infant-and-child-mortality-review-committee-2015-final-report
#1
Ann L Wilson, Jim Sideras, Brad Randall
The Regional Infant and Child Mortality Review Committee serves 10 counties in southeastern South Dakota and aims to use its reviews to prevent future loss of life during childhood. In 2015, the committee reviewed 24 deaths (compared to 32 cases in 2013 and 25 cases in 2014). Consistent with observations made in previous years, in 2015 all infants (n=7) who died during sleep did so with risks present in the sleep environment. Progress in decreasing these infant deaths in the region is not being observed, and in fact, may even be deteriorating...
October 2016: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28805934/fragility-of-epidermis-acne-and-post-procedure-lesional-skin
#2
G Fabbrocini, A B Rossi, M-D Thouvenin, C Peraud, V Mengeaud, A Bacquey, M Saint Aroman
'Fragile skin', or skin with lower resistance to aggressors, can be broadly classified into four causal categories: constitutional (age-dependent or associated with specific vulnerable locations on the body, e.g. eyelids), pathological (related to disease), circumstantial (related to environmental or internal factors, e.g. stress) and iatrogenic (caused by medical interventions or treatments). In this supplement, we focus on the fourth category, the iatrogenic origin of fragile skin and the role that dermo-cosmetics can have in restoring the natural protective function of the skin following treatments for skin diseases and medical interventions...
September 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28805717/the-fragility-index-in-a-cohort-of-pediatric-randomized-controlled-trials
#3
Travis J Matics, Nadia Khan, Priti Jani, Jason M Kane
Data suggest inadequacy of common statistical techniques for reporting outcomes in clinical trials. The Fragility Index can measure how many events the statistical significance hinges on, and may facilitate better interpretation of trial results. This study aimed to assess the Fragility Index in pediatric randomized controlled trials (RCTs) with statistically significant findings published in high-quality medical journals. A Fragility Index was calculated on included trials with dichotomous positive outcomes...
August 14, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28803135/effects-of-aging-on-basement-membrane-of-the-soleus-muscle-during-recovery-following-disuse-atrophy-in-rats
#4
Yuji Kanazawa, Keisuke Ikegami, Mitsugu Sujino, Satoshi Koinuma, Mamoru Nagano, Yuki Oi, Tomoya Onishi, Shinichi Sugiyo, Isao Takeda, Hiroshi Kaji, Yasufumi Shigeyoshi
Aging is known to lead to the impaired recovery of muscle after disuse as well as the increased susceptibility of the muscle to damage. Here, we show that, in the older rats, reloading after disuse atrophy, causes the damage of the muscle fibers and the basement membrane (BM) that structurally support the muscle fibers. Male Wistar rats of 3-(young) and 20-(older) months of age were subjected to hindlimb-unloading for 2weeks followed by reloading for a week. In the older rats, the soleus muscles showed necrosis and central nuclei fiber indicating the regeneration of muscle fibers...
August 9, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28803083/the-impact-of-combined-use-of-opioids-antipsychotics-and-anxiolytics-on-survival-in-the-hospice-setting
#5
Marin Golčić, Renata Dobrila-Dintinjana, Goran Golčić, Aleksandar Čubranić
CONTEXT: Opioids and sedatives are the cornerstone of symptom management in the end-of-life patients, but undertreatment is a common problem. Although several studies explored the individual effect of opioids, anxiolytics and antipsychotics on survival, not much is known regarding their combined use. As these drugs share similar and potentially fatal side effects, primarily respiratory depression which occurs more often during night-hours, it is crucial to explore whether their interaction poses a danger for fragile hospice patients...
August 9, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28802395/changes-in-pediatric-tracheostomy-tubes-exposed-to-home-dishwashing
#6
David E Smolar, Brian Ho, Steven M Kent, C Anthony Hughes, Donald Mettenburg, Fredrick A Rueggeberg, Michael W Groves
OBJECTIVE: Determine the effects of household dishwashing on Tracheostomy Tube safety. INTRODUCTION: Tracheostomy tubes accumulate biofilms, which may limit their lifespan. Frequent cleaning of the tubes is a method for biofilm prevention. Cleaning practices vary widely. Some families prefer dishwashing of tubes, but its effects are currently unknown. We hypothesize that dishwashing has no significant effect on the physical properties of tracheostomy tubes and can be recommended as a safe way to clean tracheostomy tubes...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28802096/comparison-of-cleaning-methods-for-delicate-insect-specimens-for-scanning-electron-microscopy
#7
Katharina Schneeberg, René Bauernfeind, Hans Pohl
The objective of the present study was to compare cleaning methods for delicate insect specimens for investigations with scanning electron microscopy (SEM). As typical specimens we used aquatic larvae of mosquitoes, springtails, larvae of mayflies and caterpillars because they are very fragile and large parts of their body consist of soft tissue. Additionally their cuticle is very often covered with dirt, soil particles or other materials. Cleaning with ultrasonic sound, as the most common cleaning method used for SEM, will destroy fragile insects...
August 12, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28801583/effect-of-x-ray-irradiation-on-hepatocarcinoma-cells-and-erythrocytes-in-salvaged-blood
#8
Feng-Jiang Zhang, Jin-Ting Yang, Li-Hui Tang, Wen-Na Wang, Kai Sun, Yue Ming, Kanhar Ghulam Muhammad, Yin-Fei Zheng, Min Yan
The broad clinical acceptance of intraoperative blood salvage and its applications in cancer surgery remain controversial. Until now, a method that can safely eliminate cancer cells while preserving erythrocytes does not exist. Here, we investigated whether X-ray generated from linear accelerator irradiation at a certain dose can kill hepatocarcinoma cells while preserving erythrocytes. HepG2, SK-Hep1 or Huh7 cells were mixed into the aliquots of erythrocytes obtained from healthy volunteers. After the mixed cells were exposed to 30 Gy and 50 Gy X-rays irradiation, the viability, clonogenicity, DNA synthesis and tumorigenicity of the tumor cells were determined by the MTT assay, plate colony formation, 5-ethynyl-2'-deoxyuridine incorporation, and subcutaneous xenograft implantation into immunocompromised mice...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801319/pet10p-is-a-yeast-perilipin-that-stabilizes-lipid-droplets-and-promotes-their-assembly
#9
Qiang Gao, Derk D Binns, Lisa N Kinch, Nick V Grishin, Natalie Ortiz, Xiao Chen, Joel M Goodman
Pet10p is a yeast lipid droplet protein of unknown function. We show that it binds specifically to and is stabilized by droplets containing triacylglycerol (TG). Droplets isolated from cells with a PET10 deletion strongly aggregate, appear fragile, and fuse in vivo when cells are cultured in oleic acid. Pet10p binds early to nascent droplets, and their rate of appearance is decreased in pet10Δ Moreover, Pet10p functionally interacts with the endoplasmic reticulum droplet assembly factors seipin and Fit2 to maintain proper droplet morphology...
August 11, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28800970/guidelines-of-the-brazilian-society-of-rheumatology-for-the-diagnosis-and-treatment-of-osteoporosis-in-men
#10
REVIEW
Marco Antônio R Loures, Cristiano Augusto F Zerbini, Jaime S Danowski, Rosa Maria R Pereira, Caio Moreira, Ana Patrícia de Paula, Charlles Heldan M Castro, Vera Lucia Szenjenfeld, Laura Maria C Mendonça, Sebastião C Radominiski, Mailze C Bezerra, Ricardo Simões, Wanderley M Bernardo
Osteoporosis, a metabolic disease characterized by low bone mass, deterioration of the bone tissue microarchitecture and increased susceptibility to fractures, is commonly regarded as a women's health problem. This point of view is based on the fact that compared with men, women have lower bone mineral density and longer lifespans and lose bone mass faster, especially after menopause, due to a marked decrease in serum estrogen levels. However, in the last 20 years, osteoporosis in men has become recognized as a public health problem due to the occurrence of an increasingly higher number of fragility fractures...
August 8, 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28800512/metabotropic-glutamate-receptors-as-emerging-research-targets-in-bipolar-disorder
#11
REVIEW
Caren J Blacker, Charles P Lewis, Mark A Frye, Marin Veldic
Glutamatergic dysregulation is implicated in the neuropathology of bipolar disorder (BD). There is increasing interest in investigating the role of metabotropic glutamate receptors (mGluRs) in BD and as a target for treatment intervention. Bipolar mGluR studies (published January 1992-April 2016) were identified via PubMed, Embase, Web of Science, and Scopus. Full-text screening, data extraction, and quality appraisal were conducted in duplicate, with strict inclusion and exclusion criteria. The initial literature search for mGluRs in BD, including non-bipolar mood disorders and primary psychotic disorders, identified 1544 articles...
July 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28799463/rebuilding-research-capacity-in-fragile-states-the-case-of-a-somali-swedish-global-health-initiative
#12
Abdirisak Ahmed Dalmar, Abdullahi Sheik Hussein, Said Ahmed Walhad, Abdirashid Omer Ibrahim, Abshir Ali Abdi, Mohamed Khalid Ali, Derie Ismail Ereg, Khadra Ali Egal, Abdulkadir Mohamed Shirwa, Mohamed Hussain Aden, Marian Warsame Yusuf, Yakoub Aden Abdi, Lennart Freij, Annika Johansson, Khalif Bile Mohamud, Yusuf Abdulkadir, Maria Emmelin, Jaran Eriksen, Kerstin Erlandsson, Lars L Gustafsson, Anneli Ivarsson, Marie Klingberg-Allvin, John Kinsman, Carina Källestål, Mats Målqvist, Fatumo Osman, Lars-Åke Persson, Klas-Göran Sahlén, Stig Wall
This paper presents an initiative to revive the previous Somali-Swedish Research Cooperation, which started in 1981 and was cut short by the civil war in Somalia. A programme focusing on research capacity building in the health sector is currently underway through the work of an alliance of three partner groups: six new Somali universities, five Swedish universities, and Somali diaspora professionals. Somali ownership is key to the sustainability of the programme, as is close collaboration with Somali health ministries...
2017: Global Health Action
https://www.readbyqxmd.com/read/28799380/a-force-level-theory-of-the-rheology-of-entangled-rod-and-chain-polymer-liquids-i-tube-deformation-microscopic-yielding-and-the-nonlinear-elastic-limit
#13
Kenneth S Schweizer, Daniel M Sussman
We employ a first-principles-based, force-level approach to construct the anharmonic tube confinement field for entangled fluids of rigid needles, and also for chains described at the primitive-path (PP) level in two limiting situations where chain stretch is assumed to either be completely equilibrated or unrelaxed. The influence of shear and extensional deformation and polymer orientation is determined in a nonlinear elastic limit where dissipative relaxation processes are intentionally neglected. For needles and PP-level chains, a self-consistent analysis of transverse polymer harmonic dynamical fluctuations predicts that deformation-induced orientation leads to tube weakening or widening...
December 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28799316/mirror-aneurysm-with-right-frontal-ich-in-a-patient-with-osteogenesis-imperfecta
#14
Vijay Sardana, Sumit Kamble, Sunil K Sharma, Dilip Maheshwari, Bharat Bhushan
Osteogenesis imperfecta (OI) is a heterogeneous group of inherited disorders that occur owing to the abnormalities in type 1 collagen, and is characterized by increased bone fragility and other extraskeletal manifestations. OI may be associated with vascular complications such as aortic and cervical artery dissection, carotid cavernous fistula, and coronary artery aneurysms but unlike other connective tissue diseases, the cerebrovascular system is less frequently involved. We report rare case of 50 year female patient who was diagnosed with OI following right frontal haemorrhage secondary to a ruptured middle cerebral artery mirror aneurysm...
August 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28798680/striatal-network-models-of-huntington-s-disease-dysfunction-phenotypes
#15
Pengsheng Zheng, James Kozloski
We present a network model of striatum, which generates "winnerless" dynamics typical for a network of sparse, unidirectionally connected inhibitory units. We observe that these dynamics, while interesting and a good match to normal striatal electrophysiological recordings, are fragile. Specifically, we find that randomly initialized networks often show dynamics more resembling "winner-take-all," and relate this "unhealthy" model activity to dysfunctional physiological and anatomical phenotypes in the striatum of Huntington's disease animal models...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28797939/informal-assistance-to-urban-families-and-the-risk-of-household-food-insecurity
#16
Christian King
RATIONALE: Food insecurity is a persistent social problem affecting one out of eight households in the United States. While evidence shows that public assistance programs (formal assistance) are effective in reducing food insecurity, there is more limited evidence documenting how informal support, through social capital, affects food insecurity. OBJECTIVE: To examine the role of informal support (through instrumental social support, social cohesion, social control, and social participation) on food insecurity transitions using longitudinal data of a sample of disadvantaged urban mothers from the Fragile Families and Child Wellbeing Study...
August 2, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28797733/propagation-of-respiratory-viruses-in-human-airway-epithelia-reveals-persistent-virus-specific-signatures
#17
Manel Essaidi-Laziosi, Francisco Brito, Sacha Benaoudia, Léna Royston, Valeria Cagno, Mélanie Fernandes-Rocha, Isabelle Piuz, Evgeny Zdobnov, Song Huang, Samuel Constant, Marc-Olivier Boldi, Laurent Kaiser, Caroline Tapparel
BACKGROUND: Leading etiologies of acute illnesses, respiratory viruses typically cause self-limited diseases, though severe complications can occur in fragile patients. Rhinoviruses, respiratory enteroviruses, influenza virus, respiratory syncytial viruses and coronaviruses are highly prevalent respiratory pathogens, but due to the lack of reliable animal models, their differential pathogenesis remains poorly characterized. OBJECTIVE: To compare infections by respiratory viruses isolated from clinical specimens using reconstituted human airway epithelia...
August 7, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28797175/role-of-lipids-and-intraplaque-hypoxia-in-the-formation-of-neovascularization-in-atherosclerosis
#18
Dimitry A Chistiakov, Alexandra A Melnichenko, Veronika A Myasoedova, Andrey V Grechko, Alexander N Orekhov
According to the current paradigm, chronic vascular inflammation plays a central role in the pathogenesis of atherosclerosis. The plaque progression is typically completed with rupture and subsequent acute cardiovascular complications. Previously, the role of adventitial vasa vasorum in atherogenesis was underestimated. However, investigators then revealed that vasa vasorum neovascularization can be observed when no clinical manifestation of atherosclerosis is present. Vasa vasorum is involved in various proatherogenic processes such as intimal accumulation of inflammatory leukocytes, intimal thickening, necrotic core formation, intraplaque hemorrhage, lesion repture, and atherothrombosis...
August 11, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28796826/health-behaviors-and-union-dissolution-among-parents-of-young-children-differences-by-marital-status
#19
Jess M Meyer, Christine Percheski
Previous research finds that marriage is associated with better health and lower mortality, and one of the mechanisms underlying this association is health-related selection out of marriage. Using longitudinal survey data from 2,348 couples from the Fragile Families and Child Wellbeing Study, we examine whether certain health behaviors-smoking and binge drinking-are associated with risk of union dissolution among couples with young children. We use discrete time hazard models to test whether associations between health behaviors and union dissolution differ between married and cohabiting parents...
2017: PloS One
https://www.readbyqxmd.com/read/28796695/the-management-of-osteoporosis-after-fragility-fracture-the-orthopaedic-perspective
#20
Jonathan Morris, Alexa J Karkenny, Jose B Toro
No abstract text is available yet for this article.
August 8, 2017: JBJS Reviews
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