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JOURNAL ARTICLE
Elina S Chelebieva, Ekaterina S Kladchenko, Igor V Mindukshev, Stepan Gambaryan, Alexandra Yu Andreyeva
Semi-anadromous animals experience salinity fluctuations during their life-span period. Alterations of environmental conditions induce stress response where catecholamines (CA) play a central role. Physiological stress and changes in external and internal osmolarity are frequently associated with increased production of reactive oxygen species (ROS). In this work, we studied the involvement of the cAMP/PKA pathway in mediating catecholamine-dependent effects on osmoregulatory responses, intracellular production of ROS, and mitochondrial membrane potential of the river lamprey (Lampetra fluviatilis, Linnaeus, 1758) red blood cells (RBCs)...
April 22, 2024: Fish Physiology and Biochemistry
#2
JOURNAL ARTICLE
Fan Wang, Hui Li, Kaijun Yi, Yan Wu, Qingtao Bian, Baoyan Guo, Xingguang Luo, Yimin Kang, Qi Wu, Qinghe Ma
RATIONALE: Patients with schizophrenia with second-generation antipsychotics (SGAs) treatment have shown an increased risk of bone fragility and susceptibility to fracture; however, it is still unclear whether this risk is derived from the effect of antipsychotics on balance of bone metabolism. OBJECTIVES: We investigated the changes of two bone turnover biomarkers (BTMs) concentrations in people with schizophrenia receiving SGAs: procollagen type I aminoterminal propeptide (PINP) and C-terminal telopeptide of type I collagen (CTX-1) as BTMs of osteogenesis and bone resorption, respectively, to explore how antipsychotics contribute to bone fragility...
April 22, 2024: Psychopharmacology
#3
JOURNAL ARTICLE
Kei Sakamoto, Osamu Miyazaki, Ayako Imai, Reiko Okamoto, Yoshiyuki Tsutsumi, Mikiko Miyasaka, Atsuhito Seki, Takako Yoshioka, Shunsuke Nosaka
Osteoid osteoma (OO) is a common, benign bone tumor. However, there are no case reports of OO associated with osteogenesis imperfecta (OI), or pathological fractures in OO. A 3-year-old girl with OI sustained a complete right tibial diaphyseal fracture. Bony fusion was completed after 4 months of conservative therapy; nevertheless, 18 months later spontaneous pain appeared at the fracture site, without any cause. Plain radiographs showed a newly apparent, rounded area of translucency 1 cm in diameter, just overlapping the previous fracture...
April 22, 2024: Skeletal Radiology
#4
JOURNAL ARTICLE
Yao He, Chang-Shun Sun, Yi-Ming Hou, En Hu, Xiang-Ran Hou, Zhi-Yuan Feng, Xu-da Zhang, Bao-Zhu Pan
Yanhe River Basin is located in the hilly gully area of the Loess Plateau with serious soil erosion. Strong human activities in the middle and lower reaches lead to fragile ecological environment. Soil erosion status varies among different geomorphic units within the watershed (loess liang hilly and gully region, loess mao hilly and gully region, and broken platform region). In this study, we surveyed the benthic community from the Yanhe River Basin in April (spring) and October (autumn) of 2021. To evaluate the water ecological health status of the watershed and investigate the effects of different geomorphic units on the benthic integrity of the benthos, we constructed the benthic-index of biotical integrity (B-IBI) based on the biological data...
March 18, 2024: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
#5
JOURNAL ARTICLE
Hao-Qin Yang, Hai-Bing Wang, He-Jun Zuo, Shuo Qiao, Si-Qi Li
Understanding land structure change and stability in the process of oasisization is particularly important for the desertification control in sandy land. Based on land use data of eight periods from 1980 to 2020, we extracted the spatial distribution information of oasis land in Mu Us Sandy Land, and analyzed the spatio-temporal variations of land transformation patterns and stability of oasis land with overlay analysis and grid analysis. The results showed that desertification in the Mu Us Sandy Land had reversed, with a significant process of oasis...
March 18, 2024: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
#6
JOURNAL ARTICLE
Michael J Turnbull, Iwen Grigsby, Karl Unertl, Kerry Sokol, Tera Nordby, Cedric Liu, Anna Bailey, Brian Spiewak, Graham Smith, Amy K McNulty
BACKGROUND: Medical tapes can lead to skin damage upon removal in susceptible patients with fragile skin and at higher risk of developing tissue injury. PURPOSE: We compared the effect of medical tapes with silicone-based versus acrylate-based adhesives on the back or volar forearm stratum corneum using analytical techniques to assess skin condition and potential damage post product removal on 88 healthy volunteers. METHODS: Two studies were conducted in separate facilities (Study 1: 3M In-house Clinical Facility, St...
March 2024: Curēus
#7
JOURNAL ARTICLE
Lamia Aldhbiban, Fai Alhoshan, Raghad Alomari, Shahad A Almatrafi, Yousef Alanazi, Samir Alsayegh, Haifa Y Alfaraidi, Ayman H Jawadi, Fahad N Aljuraibah
BACKGROUND: Children's bones are at high risk of fracture as they grow. The clinical characteristics of fractures in children differ from those in adults. Studying fractures in healthy children is critical for identifying cases of fragility fractures. The aim of this study was to assess the clinical characteristics of limb fractures as well as clinical indicators of fracture healing outcomes in healthy Saudi children seen in an emergency room. METHODS: A retrospective review of the treatment course of all pediatric fractures and related factors treated at King Abdullah Specialist Children's Hospital (KASCH) in Riyadh between 2016 and 2018 was conducted...
March 2024: Curēus
#8
Guiyuan He, Xi Wang, Beiqing Li, Lei Wang, Jing Zhang, Yang Shi, Wenxiu Zhu, Ming Shi
PURPOSE: Fragile sites are specific chromosomal regions showing gaps, poor staining, contractions, or even breaks in the chromosomes. These spontaneous and heritable fragile sites are prone to structural variations which can lead to adverse reproductive outcomes. This paper aims to present a specific case study of a female patient, with a mosaic karyotype involving chromosome 16q22 fragile site which is very rare in clinic and her experience of infertility. CASE PRESENTATION: A 37-year-old woman is diagnosed with ten-year primary infertility...
2024: International Journal of Women's Health
#9
Haeseong Lee, Bach Le, Parish Sedghizadeh
Dens evaginatus (DE) presents a clinical conundrum due to its fragility and propensity to cause pulpal and periapical complications. Clinicians should heed the presence of DE during clinical examinations and avoid unnecessary intervention.
April 2024: Clinical Case Reports
#10
Carson Whinnery, Ying Nie, Danilo S Boskovic, Salvador Soriano, Wolff M Kirsch
Cerebral amyloid angiopathy is characterized by a weakening of the small and medium sized cerebral arteries, as their smooth muscle cells are progressively replaced with acellular amyloid β, increasing vessel fragility and vulnerability to microhemorrhage. In this context, an aberrant overactivation of the complement system would further aggravate this process. The surface protein CD59 protects most cells from complement-induced cytotoxicity, but expression levels can fluctuate due to disease and vary between cell types...
April 1, 2024: Research Square
#11
Fabio Vescini, Giorgio Borretta, Iacopo Chiodini, Marco Boniardi, Marina Carotti, Elena Castellano, Cristiana Cipriani, Cristina Eller-Vainicher, Sandro Giannini, Maurizio Iacobone, Antonio Stefano Salcuni, Federica Saponaro, Stefano Spiezia, Annibale Versari, Guido Zavatta, Zuzana Mitrova, Rosella Saulle, Simona Vecchi, Debora Antonini, Michele Basile, Alexia Giovanazzi, Agostino Paoletta, Enrico Papini, Agnese Persichetti, Irene Samperi, Alessandro Scoppola, Roberto Novizio, Pietro Giorgio Calò, Filomena Cetani, Luisella Cianferotti, Sabrina Corbetta, Maria Luisa De Rimini, Alberto Falchetti, Giovanni Iannetti, Stefano Laureti, Celestino Pio Lombardi, Bruno Madeo, Claudio Marcocci, Sandro Mazzaferro, Vittorio Miele, Salvatore Minisola, Andrea Palermo, Jessica Pepe, Alfredo Scillitani, Laura Tonzar, Franco Grimaldi, Renato Cozzi, Roberto Attanasio
AIM: This guideline (GL) is aimed at providing a clinical practice reference for the management of sporadic primary hyperparathyroidism (PHPT) in adults. PHPT management in pregnancy was not considered. METHODS: This GL has been developed following the methods described in the Manual of the Italian National Guideline System. For each question, the panel appointed by Associazione Medici Endocrinology (AME) and Società Italiana dell'Osteoporosi, del Metabolismo Minerale e delle Malattie dello Scheletro (SIOMMMS) identified potentially relevant outcomes, which were then rated for their impact on therapeutic choices...
December 23, 2023: Endocrine, Metabolic & Immune Disorders Drug Targets
#12
JOURNAL ARTICLE
Dhairya A Lakhani, Amit K Agarwal, Erik H Middlebrooks
Fragile X tremor/ataxia syndrome (FXTAS) is an adult-onset neurodegenerative disorder characterized by premutation expansion of fragile X mental retardation 1 (FMR1) gene. It is a common single-gene cause of tremor, ataxia, and cognitive decline in adults. FXTAS affects the central, peripheral and autonomic nervous systems, leading to a range of neurological symptoms from dementia to dysautonomia. A characteristic imaging feature of FXTAS is symmetric T2 hyperintensity in the deep white matter of the cerebellar hemispheres and middle cerebral peduncle...
April 21, 2024: Neuroradiology Journal
#13
JOURNAL ARTICLE
Ana Isabel Hormigo-Sánchez, Marta Neira-Álvarez, Teresa Pareja-Sierra
Osteoporosis is a metabolic and systemic disease characterized by alterations at the level of bone tissue with loss of bone mineral density, changes in microarchitecture, mineralization and remodeling that determine greater bone fragility and risk of fracture. Falls in the elderly are a risk factor closely related to fragility fractures and numerous studies demonstrate this relationship. Vertebral fractures are a major cause of morbidity and mortality. The epidemiology differs from osteoporotic fractures at other skeletal sites, as only one-third are clinically recognized...
April 18, 2024: Revista Española de Cirugía Ortopédica y Traumatología
#14
JOURNAL ARTICLE
P Checa-Betegón, R Luque-Pérez, D Oñate Martínez-Olascoaga, J L Pérez-González, I Domínguez-Esteban
Osteoporosis, and the consequences derived from it, such as fragility fractures, constitute a growing public health problem. Suffering from a fracture of this nature is the main risk factor for suffering a new fracture. It is documented that vertebral compression fractures lead to significant morbidity and mortality, in the short and long term, as well as other complications, such as sagittal imbalance and hyperkyphosis of the segment. However, we have not found documentation that analyzes the medium and long-term consequences of these injuries, assessing the type of treatment used, and the economic impact they represent...
April 18, 2024: Revista Española de Cirugía Ortopédica y Traumatología
#15
REVIEW
Katiuska González-Arzola
The perception that the nucleoli are merely the organelles where ribosome biogenesis occurs is challenged. Only around 30 % of nucleolar proteins are solely involved in producing ribosomes. Instead, the nucleolus plays a critical role in controlling protein trafficking during stress and, according to its dynamic nature, undergoes continuous protein exchange with nucleoplasm under various cellular stressors. Hence, the concept of nucleolar stress has evolved as cellular insults that disrupt the structure and function of the nucleolus...
April 18, 2024: Biochimica et Biophysica Acta. Gene Regulatory Mechanisms
#16
JOURNAL ARTICLE
Carla Colombo, Daniele Ceruti, Massimiliano Succi, Simone De Leo, Matteo Trevisan, Claudia Moneta, Laura Fugazzola
BACKGROUND: Fatigue is a frequent adverse event during systemic treatments for advanced thyroid cancer, often leading to reduction, interruption or discontinuation. We were the first group to demonstrate a correlation between fatigue and primary adrenal insufficiency (PAI). AIM: To assess the entire adrenal function in patients on systemic treatments. METHODS: ACTH, cortisol and all the hormones produced by the adrenal gland were evaluated monthly in 36 patients (25 on lenvatinib, 6 on vandetanib, and 5 on selpercatinib)...
April 1, 2024: European Thyroid Journal
#17
JOURNAL ARTICLE
Sansin Tuzun, Ulku Akarirmak, Bilal Kulaksiz, Aslinur Keles, Dilara Okutan, Pinar Karsli, Sevgi Selin Kurtoglu, Eren Aygun, Deniz Palamar
UNLABELLED: Although FRAX is used for fracture risk evaluation, this tool does not include balance and fall risk. The association between the predictors of falls and high FRAX scores we found in this study suggests that risk indicators for falls may add substantial value to FRAX by improving fracture risk prediction. PURPOSE: This observational, descriptive, and cross-sectional study aimed to assess the fall risk predictors and explore their association with FRAX in Turkish patients with postmenopausal osteoporosis...
April 20, 2024: Archives of Osteoporosis
#18
JOURNAL ARTICLE
Vincenzo Levi, Mario Stanziano, Carmela Pinto, Federica Zibordi, Davide Fedeli, Valentina Caldiera, Roberto Cilia, Nico Golfrè Andreasi, Arianna Braccia, Carla Carozzi, Elisa Ciceri, Marina Grisoli, Marco Gemma, Vittoria Nazzi, Francesco DiMeco, Roberto Eleopra, Giovanna Zorzi
BACKGROUND: Invasive treatments like radiofrequency stereotactic lesioning or deep brain stimulation of the globus pallidus internus can resolve drug-resistant status dystonicus (SD). However, these open procedures are not always feasible in patients with SD. OBJECTIVE: The aim was to report the safety and efficacy of simultaneous asleep bilateral transcranial magnetic resonance-guided focused ultrasound (MRgFUS) pallidotomy for life-threatening SD. METHODS: We performed bilateral simultaneous MRgFUS pallidotomy under general anesthesia in 2 young patients with pantothenate kinase-associated neurodegeneration and GNAO1 encephalopathy...
April 19, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
#19
JOURNAL ARTICLE
Tara K Crawford, Brittany N Lafaver, Charlotte L Phillips
Osteogenesis imperfecta (OI) is a rare heritable connective tissue disorder of skeletal fragility with an incidence of roughly 1:15,000. Approximately 85% of the pathogenic variants responsible for OI are in the type I collagen genes, COL1A1 and COL1A2, with the remaining pathogenic OI variants spanning at least 20 additional genetic loci that often involve type I collagen post-translational modification, folding, and intracellular transport as well as matrix incorporation and mineralization. In addition to being the most abundant collagen in the body, type I collagen is an important structural and extracellular matrix signaling molecule in multiple organ systems and tissues...
April 19, 2024: Calcified Tissue International
#20
JOURNAL ARTICLE
Jian Gao, Yi Zhang, Yanbin Bi, Keke Du, Jixing Su, Shuangbao Zhang
Natural plant fiber-reinforced bio-based polymer composites are widely attracting attention because of their economical, readily available, low carbon, and biodegradable, and showing promise in gradually replacing petroleum-based composites. Nevertheless, the fragile interfacial bonding between fiber and substrate hinders the progression of low-cost and abundant sustainable high-performance biocomposites. In this paper, a novel high-performance sustainable biocomposite was built by introducing a high density strong hydrogen-bonded bridging interface based on tannic acid (TA) between bamboo fibers (BFs) and PBSA...
April 17, 2024: International Journal of Biological Macromolecules
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