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https://www.readbyqxmd.com/read/29161773/silodosin-for-the-treatment-of-lower-urinary-tract-symptoms-in-men-with-benign-prostatic-hyperplasia
#1
REVIEW
Jae Hung Jung, Jiye Kim, Roderick MacDonald, Balaji Reddy, Myung Ha Kim, Philipp Dahm
BACKGROUND: A variety of alpha-blockers are used for treating lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH). Silodosin is a novel, more selective alpha-blocker, which is specific to the lower urinary tract and may have fewer side effects than other alpha-blockers. OBJECTIVES: To assess the effects of silodosin for the treatment of LUTS in men with BPH. SEARCH METHODS: We performed a comprehensive search using multiple databases (Cochrane Library, MEDLINE, EMBASE, Scopus, Google Scholar, and Web of Science), trials registries, other sources of grey literature, and conference proceedings with no restrictions on the language of publication or publication status up until 13 June 2017...
November 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29161684/higher-versus-lower-continuous-renal-replacement-therapy-intensity-in-critically-ill-patients-with-liver-dysfunction
#2
Zachary O'Brien, Alan Cass, Louise Cole, Simon Finfer, Martin Gallagher, Colin McArthur, Shay McGuiness, John Myburgh, Rinaldo Bellomo, Johan Mårtensson
AIMS: To study the association between higher versus lower continuous renal replacement therapy (CRRT) intensity and mortality in critically ill patients with combined acute kidney injury and liver dysfunction. METHODS: Post-hoc analysis of patients with liver dysfunction (Sequential Organ Failure Assessment liver score ≥2 or diagnosis of liver failure/transplant) included in the Randomized Evaluation of Normal versus Augmented Level renal replacement therapy (RENAL) trial...
November 22, 2017: Blood Purification
https://www.readbyqxmd.com/read/29161549/ultrasound-guided-versus-conventional-injection-for-caudal-block-in-children-a-prospective-randomized-clinical-study
#3
Ali Ahiskalioglu, Ahmet Murat Yayik, Elif Oral Ahiskalioglu, Mursel Ekinci, Birzat Emre Gölboyu, Erkan Cem Celik, Haci Ahmet Alici, Akgun Oral, Saban Oguz Demirdogen
STUDY OBJECTIVE: The aim of this study was to compare the efficacies of ultrasound guided sacral hiatus injection and conventional sacral canal injection performed for caudal block in children. DESIGN: Randomized controlled clinical trial. SETTING: Operating rooms of university hospital of Erzurum, Turkey. PATIENTS: One hundred-thirty four children, American Society of Anesthesiologists I-II, between the ages of 5 and 12, scheduled for elective phimosis and circumcision surgery...
November 18, 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29161523/does-acute-propranolol-treatment-prevent-posttraumatic-stress-disorder-anxiety-and-depression-in-children-with-burns
#4
Laura Rosenberg, Marta Rosenberg, Sherri Sharp, Christopher R Thomas, Helen F Humphries, Charles E Holzer, David N Herndon, Walter J Meyer
OBJECTIVE: This study examined whether acute propranolol treatment prevented posttraumatic stress disorder (PTSD), anxiety, and depression in children hospitalized in the pediatric intensive care unit for large burns. We hypothesized that the prevalence of PTSD, anxiety, and depression would be significantly less in the propranolol than nonpropranolol groups. METHODS: Children who had previously participated in a randomized controlled clinical trial of acute propranolol and nonpropranolol controls were invited to participate in long-term follow-up interviews...
November 21, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29161458/proton-pump-inhibitors-for-functional-dyspepsia
#5
REVIEW
Maria Ines Pinto-Sanchez, Yuhong Yuan, Ahmed Hassan, Premysl Bercik, Paul Moayyedi
BACKGROUND: Functional dyspepsia (FD or non-ulcer dyspepsia) is defined as continuous or frequently recurring epigastric pain or discomfort for which no organic cause can be found. Acid suppressive therapy, including proton pump inhibitors (PPIs), has been proposed as a therapeutic option in FD, but its efficacy remains controversial. While PPIs are generally considered safe and well tolerated, they have been associated with adverse events, especially in the long term. For this reason, decisions on whether to initiate or continue PPI therapy should be made based on an appropriate clinical indication...
November 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29161424/clinical-impact-of-implantable-cardioverter-defibrillator-in-primary-prevention-of-total-mortality-in-non-ischaemic-cardiomyopathy-results-from-a-meta-analysis-of-prospective-randomized-clinical-trials
#6
Jorge Romero, Juan Carlos Díaz, Michael Grushko, Renato Quispe, David Briceno, Ricardo Avendano, Anjani Golive, Ileana Pina, Andrea Natale, Mario J Garcia, Ulrich P Jorde, Luigi Di Biase
Aim: Primary prophylactic implantable cardioverter defibrillators (ICDs) have demonstrated a clear all-cause mortality benefit in patients with ischaemic cardiomyopathy, with less compelling evidence supporting its use in patients with non-ischaemic cardiomyopathy (NICM). We performed a meta-analysis of randomized controlled trials (RCTs) evaluating the role of ICD for reduction in total mortality in NICM patients. Methods and results: An electronic search on PubMed, the Cochrane Library, and EMBASE databases was performed to identify the RCTs evaluating the role of prophylactic ICD placement in NICM patients...
November 17, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29161417/bolus-weekly-vitamin-d3-supplementation-impacts-gut-and-airway-microbiota-in-adults-with-cystic-fibrosis-a-double-blind-randomized-placebo-controlled-clinical-trial
#7
Mansi Kanhere, Jiabei He, Benoit Chassaing, Thomas R Ziegler, Jessica A Alvarez, Elizabeth A Ivie, Li Hao, John Hanfelt, Andrew T Gewirtz, Vin Tangpricha
Background: Disruption of gut microbiota may exacerbate severity of cystic fibrosis (CF). Vitamin D deficiency is a common co-morbidity in patients with CF that may influence composition of the gut microbiota. Objectives: Compare microbiota of vitamin D sufficient and insufficient CF patients, and assess impact of a weekly high-dose vitamin D3 bolus regimen on gut and airway microbiome in adults with CF and vitamin D insufficiency (25(OH)D <30 ng/mL). Design: Forty-one subjects with CF were classified into two groups - vitamin D insufficient (n=23) and vitamin D sufficient (n=18)...
November 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29161385/are-we-close-to-the-ideal-intravenous-fluid
#8
N MacDonald, R M Pearse
The approach to i.v. fluid therapy for hypovolaemia may significantly influence outcomes for patients who experience a systemic inflammatory response after sepsis, trauma, or major surgery. Currently, there is no single i.v. fluid agent that meets all the criteria for the ideal treatment for hypovolaemia. The physician must choose the best available agent(s) for each patient, and then decide when and how much to administer. Findings from large randomized trials suggest that some colloid-based fluids, particularly starch-based colloids, may be harmful in some situations, but it is unclear whether they should be withdrawn from use completely...
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29161371/long-term-remineralizing-effect-of-mi-paste-plus-on-regression-of-early-caries-after-orthodontic-fixed-appliance-treatment-a-12-month-follow-up-randomized-controlled-trial
#9
Moniek W Beerens, Jacob M Ten Cate, Mark J Buijs, Monique H van der Veen
Background: Casein-phosphopeptide-amorphous-calcium-fluoride-phosphate (CPP-ACFP) can remineralize subsurface lesions. It is the active ingredient of MI-Paste-Plus® (MPP). The long-term remineralization efficacy is unknown. Objective: To evaluate the long-term effect of MPP versus a placebo paste on remineralization of enamel after fixed orthodontic treatment over a 12-month period. Design: This trial was designed as a prospective, double-blinded, placebo-controlled RCT...
November 17, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29161260/hiv-self-testing-among-female-sex-workers-in-zambia-a-cluster-randomized-controlled-trial
#10
Michael M Chanda, Katrina F Ortblad, Magdalene Mwale, Steven Chongo, Catherine Kanchele, Nyambe Kamungoma, Andrew Fullem, Caitlin Dunn, Leah G Barresi, Guy Harling, Till Bärnighausen, Catherine E Oldenburg
BACKGROUND: HIV self-testing (HIVST) may play a role in addressing gaps in HIV testing coverage and as an entry point for HIV prevention services. We conducted a cluster randomized trial of 2 HIVST distribution mechanisms compared to the standard of care among female sex workers (FSWs) in Zambia. METHODS AND FINDINGS: Trained peer educators in Kapiri Mposhi, Chirundu, and Livingstone, Zambia, each recruited 6 FSW participants. Peer educator-FSW groups were randomized to 1 of 3 arms: (1) delivery (direct distribution of an oral HIVST from the peer educator), (2) coupon (a coupon for collection of an oral HIVST from a health clinic/pharmacy), or (3) standard-of-care HIV testing...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29161138/autologous-matrix-induced-chondrogenesis-a-systematic-review-of-the-clinical-evidence
#11
Liang Gao, Patrick Orth, Magali Cucchiarini, Henning Madry
BACKGROUND: The addition of a type I/III collagen membrane in cartilage defects treated with microfracture has been advocated for cartilage repair, termed "autologous matrix-induced chondrogenesis" (AMIC). PURPOSE: To examine the current clinical evidence regarding AMIC for focal chondral defects. STUDY DESIGN: Systematic review. METHODS: A systematic review was performed by searching PubMed, ScienceDirect, and Cochrane Library databases...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29160598/a-randomized-8-week-double-blind-placebo-controlled-trial-of-vortioxetine-in-japanese-adults-with-major-depressive-disorder-followed-by-a-52-week-open-label-extension-trial
#12
Takeshi Inoue, Akira Nishimura, Kiyofumi Sasai, Tadayuki Kitagawa
AIM: Safety and efficacy of vortioxetine (5-20 mg/day) in Japanese patients with major depressive disorder were evaluated in two phase 3 studies consisting of a short-term, 8-week, placebo-controlled, double-blind study followed by a long-term, 52-week, open-label extension study. METHODS: The primary endpoint of the short-term study was change from baseline in Montgomery-Åsberg Depression Rating Scale (MADRS) total score at week 8. The primary objective of the extension study was vortioxetine's long-term safety; efficacy endpoints included change in MADRS total score, clinical global impression scale-severity (CGI-S) score from the long-term study baseline, and clinical global impression scale-improvement (CGI-I) score over 52 weeks...
November 21, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29160486/influence-of-therapeutic-play-on-the-anxiety-of-hospitalized-school-age-children-clinical-trial
#13
Sabrina Gisele Tobias da Silva, Maiara Aurichio Santos, Claudia Maria de Freitas Floriano, Elaine Buchhorn Cintra Damião, Fernanda Vieira de Campos, Lisabelle Mariano Rossato
OBJECTIVE: To evaluate the effects of Dramatic Therapeutic Play (DTP) technique on the degree of anxiety in hospitalized school-age children. METHOD: Randomized clinical trial performed in two hospitals ofSão Paulo, between May and October 2015. The intervention consisted of the application of DTP and the outcome was evaluated through the Child Drawing: Hospital (CD: H) instrument. The Wilcoxon-Mann Whitney, Corrected t, Fisher's exact and Chi-square tests were used in the analysis...
November 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29160424/effect-of-prophylactic-non-invasive-mechanical-ventilation-on-functional-capacity-after-heart-valve-replacement-a-clinical-trial
#14
Amaro Afrânio de Araújo-Filho, Manoel Luiz de Cerqueira-Neto, Lucas de Assis Pereira Cacau, Géssica Uruga Oliveira, Telma Cristina Fontes Cerqueira, Valter Joviniano de Santana-Filho
OBJECTIVE: During cardiac surgery, several factors contribute to the development of postoperative pulmonary complications. Non-invasive ventilation is a promising therapeutic tool for improving the functionality of this type of patient. The aim of this study is to evaluate the functional capacity and length of stay of patients in a nosocomial intensive care unit who underwent prophylactic non-invasive ventilation after heart valve replacement. METHOD: The study was a controlled clinical trial, comprising 50 individuals of both sexes who were allocated by randomization into two groups with 25 patients in each group: the control group and experimental group...
October 2017: Clinics
https://www.readbyqxmd.com/read/29160391/agnps-the-new-allies-against-s-mutans-biofilm-a-pilot-clinical-trial-and-microbiological-assay
#15
Priscila L L Freire, Allan J R Albuquerque, Fabio C Sampaio, André Galembeck, Miguel A P Flores, Thayza C M Stamford, Aronita Rosenblatt
The purpose of this study was to evaluate the antimicrobial properties of a new formulation containing silver nanoparticles, named Nano Silver Fluoride (NSF), to inhibit Streptococcus mutans biofilm formation on children's dental enamel. The variations in dental biofilm pH and in the Simplified-Oral-Hygiene-Index (OHI-S) also were evaluated after the treatment with NSF. This was a randomized, double-blind, crossover and prospective pilot clinical trial study in which 12 schoolchildren, aged between 7-8 years, had their dental enamel treated with two solutions: S1 - Nano Silver Fluoride and S2 - negative control (saline solution), in different experimental moments...
July 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29160101/postoperative-analgesia-using-peripheral-anesthetic-block-of-the-foot-and-ankle
#16
Kelly Cristina Stéfani, Gabriel Ferraz Ferreira, Miguel Viana Pereira Filho
BACKGROUND: Anesthetic block of the peripheral nerves in the foot and ankle is generally used as anesthesia. The increased use of anesthetic blocks has made this technique an increasingly safe method, and its use has been expanded to postoperative analgesia in foot and ankle surgeries. The objective of this study was to evaluate the analgesia time and pain intensity, using objective scores, after peripheral nerve block in foot and ankle surgeries. METHODS: Patients who underwent surgery by the foot and ankle group of our institution from March 2016 to January 2017 were invited to participate in this prospective, randomized, and blinded study after signing an informed consent form...
November 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/29159993/low-fodmaps-diet-vs-general-dietary-advice-improves-clinical-response-in-patients-with-diarrhea-predominant-irritable-bowel-syndrome-a-randomized-controlled-trial
#17
Mohammad Javad Zahedi, Vahideh Behrouz, Maryam Azimi
BACKGROUND AND AIMS: Recent evidence indicates that new approach of the diet with low Fermentable Oligo-Di-Mono-saccharides and polyols (FODMAPs) may has an effective role in management of the patients with irritable bowel syndrome (IBS). We compared the results of low FODMAP diet vs. current dietary treatment, general dietary advices (GDA), on the clinical response in patients with diarrhea subtype of IBS (IBS-D). METHODS: In this randomized, controlled, single-blind trial, we included 110 patients with IBS-D in 2 intervention groups...
November 20, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29159815/effectiveness-of-interventions-for-breast-cancer-screening-in-african-american-women-a-meta-analysis
#18
Valire Carr Copeland, Yoo Jung Kim, Shaun M Eack
OBJECTIVE: The purpose of this study was to report the results of a meta-analysis conducted on the effects of clinical trials in breast cancer screening for African American women between 1997 and 2017. DATA SOURCES: Articles published in English and in the United States, between January 1997 and March 2017, were eligible for inclusion if they (1) conducted psychosocial, behavioral, or educational interventions designed to increase screening mammography rates in predominantly African American women of all ages; (2) utilized a randomized, controlled trial (RCT) design; and (3) reported quantitative screening rates following the intervention...
November 21, 2017: Health Services Research
https://www.readbyqxmd.com/read/29159776/non-pharmacological-interventions-in-patients-with-spinal-cord-compression-a-systematic-review
#19
REVIEW
María Paniagua-Collado, Omar Cauli
Spinal cord compression is a complex and challenging condition that greatly affects the quality of life. Non-pharmacological techniques have only been studied to a very lesser extent; although they are evidence to be beneficial. We performed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) analysis of the scientific literature in several databases (Medline, Cochrane, Scopus, Cuiden, Pubmed, Lilacs and Embase); using the following keywords: spinal cord compression, spine compression, mobilization, positioning, brace and bracing...
November 20, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29159692/germacrone-and-sesquiterpene-enriched-extracts-from%C3%A2-curcuma-aeruginosa-roxb-increase-skin-penetration-of-minoxidil-a-hair-growth-promoter
#20
Jukkarin Srivilai, Neti Waranuch, Anothai Tangsumranjit, Nantaka Khorana, Kornkanok Ingkaninan
Minoxidil is approved for topical treatment of androgenic alopecia but hampered by poor cutaneous absorption. Recently, the randomized control trial showed that hair loss treatment of minoxidil was improved by co-application of the anti-androgen, Curcuma aeruginosa Roxb. extract. Here, we aimed to show that the apparent synergism arises from improved cutaneous penetration of minoxidil by bioactive compound, germacrone or C. aeruginosa (as an n-hexane extract, or essential oil). The partition coefficient of germacrone was determined by HPLC...
November 20, 2017: Drug Delivery and Translational Research
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