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https://www.readbyqxmd.com/read/28931488/carboxylate-cross-linked-cyclodextrin-a-nanoporous-scaffold-for-enhancement-of-rosuvastatin-oral-bioavailability
#1
Mai Mahmoud Gabr, Sana Mohamed Mortada, Marwa Ahmed Sallam
Cyclodextrins play an important role in supramolecular chemistry acting as building blocks than can be cross-linked by various linker molecules forming nano-porous structures called nanosponges (NS). NS have the ability to enhance the stability, solubility and bioavailability of various actives. This work aimed at elaborating rosuvastatin (ROS) loaded NS to improve its oral bioavailability. Carboxylate-linked NS were synthesized by reacting β-CD with pyromellitic dianhydride (PDA) at different molar ratios under specific conditions...
September 17, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28911971/the-effects-of-house-dust-mite-sublingual-immunotherapy-slit-tablet-effects-on-immunological-biomarkers-and-nasal-allergen-challenge-symptoms
#2
Natasha C Gunawardana, Qing Zhao, Leonidas N Carayannopoulos, Kuenhi Tsai, Vladislav A Malkov, Diana Selverian, Graham Clarke, Tim Mant, Brent Butts, Kaare Lund, Trevor T Hansel, Hendrik Nolte
SQ HDM SLIT-tablet significantly increased serum HDM-specific IgG4 and IgE blocking factor, and significantly decreased early phase nasal symptoms after nasal allergen challenge. No significant effects on cytokines or gene expression in nasal mucosa were observed.
September 11, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28854590/double-blind-randomized-controlled-trial-of-letrozole-versus-clomiphene-citrate-in-subfertile-women-with-polycystic-ovarian-syndrome
#3
S A Amer, J Smith, A Mahran, P Fox, A Fakis
STUDY QUESTION: Would letrozole as a primary ovulation induction agent generate better pregnancy rates than clomiphene citrate (CC) in subfertile women with anovulatory polycystic ovarian syndrome (PCOS)? SUMMARY ANSWER: Participants receiving letrozole as a primary treatment achieved a significantly (P = 0.022) higher clinical pregnancy rate per patient (61.2%) compared to CC (43.0%). WHAT IS KNOWN ALREADY: According to a recent Cochrane systematic review (2014), letrozole appears to improve live-birth (LB) and pregnancy rates in anovulatory women with PCOS, compared to CC...
August 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28844318/tolerability-of-the-sq-tree-slit-tablet-in-adults
#4
Anne O Birk, Jens S Andersen, Hanne H Villesen, Maria A Steffensen, Moises A Calderon
PURPOSE: The tree pollen sublingual immunotherapy (SLIT)-tablet (ALK, Denmark) is being developed for the treatment of tree pollen induced allergic rhinitis with or without conjunctivitis. The objective of this Phase I trial was to investigate the tolerability and acceptable dose range of the SQ tree SLIT-tablet in adults with allergic rhinoconjunctivitis. METHODS: The trial was a randomized, double-blind, placebo-controlled, dose escalation Phase I trial that included 70 adults (aged 19-61 years) with birch pollen-induced rhinoconjunctivitis with or without mild to moderate asthma...
August 22, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28825533/analysis-of-closely-related-antioxidant-nutraceuticals-using-the-green-analytical-methodology-of-ann-and-smart-spectrophotometric-methods
#5
Mohamed A Korany, Azza A Gazy, Essam F Khamis, Marwa A A Ragab, Miranda F Kamal
Two new, simple, and specific green analytical methods are proposed: zero-crossing first-derivative and chemometric-based spectrophotometric artificial neural network (ANN). The proposed methods were used for the simultaneous estimation of two closely related antioxidant nutraceuticals, coenzyme Q10 (Q10) and vitamin E, in their mixtures and pharmaceutical preparations. The first method is based on the handling of spectrophotometric data with the first-derivative technique, in which both nutraceuticals were determined in ethanol, each at the zero crossing of the other...
January 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28814387/effects-of-nk1-receptors-on-gastric-motor-functions-and-satiation-in-healthy-humans-results-from-a-controlled-trial-with-the-nk1-antagonist-aprepitant
#6
Deepti Jacob, Irene A Busciglio, Duane D Burton, Houssam Halawi, Ibironke Oduyebo, Deborah Rhoten, Michael Ryks, W Scott Harmsen, Michael Camilleri
Aprepitant, an NK1 receptor antagonist, is approved for the treatment of chemotherapy-induced or postoperative emesis by blocking NK1 receptors in the brain stem vomiting center. Effects of NK1 receptors on gastric functions and postprandial symptoms in humans are unclear; a single, crossover study did not show a significant effect of aprepitant on gastrointestinal transit. Our aim was to compare, in a randomized, double-blind, placebo-controlled, parallel-group study (12 healthy volunteers per group), effects of aprepitant vs...
August 16, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28814094/the-role-of-pegaptanib-sodium-in-the-suppression-of-epidural-fibrosis-in-a-postlaminectomy-rat-model
#7
I Sertbas, A Yilmaz, T Yildirim, M Karatay, H Celik, M A Bayar
OBJECTIVE: Spinal epidural fibrosis is a clinical condition that develops after laminectomy and can compress the spine. Many agents have been tried for the treatment, but none has entered clinical use at present. Pegaptanib sodium is an antiangiogenetic drug that prevents the development of new vessels and thus adhesion by inhibiting the effect of VEGF. MATERIAL AND METHOD: 20 Wistar rats were used in this study. The rats were divided into 2 different groups as the control and pegaptanib sodium group...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28752803/designing-and-collecting-data-for-a-longitudinal-study-the-sleman-health-and-demographic-surveillance-system-hdss
#8
Fatwa S T Dewi, Ifta Choiriyyah, Citra Indriyani, Abdul Wahab, Lutfan Lazuardi, Agung Nugroho, Susetyowati Susetyowati, Rosalia K Harisaputra, Risalia Santi, Septi K Lestari, Nawi Ng, Mohammad Hakimi, Hari K Josef, Adi Utarini
BACKGROUND: This paper describes the methodological considerations of developing an urban Health and Demographic Surveillance System (HDSS), in the Sleman District of Yogyakarta, Indonesia. METHODS: 1) The Sleman District was selected because it is mostly an urban area. 2) The minimum sample size was calculated to measure infant mortality as the key variable and resulted in a sample of 4942 households. A two-stage cluster sampling procedure with probability proportionate to size was applied; first, 216 Censuses Blocks (CBs) were selected, and second, 25 households in each CB were selected...
July 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28719717/audiometry-results-and-teoae-and-dpoae-amplitudes-in-men-taking-a-phosphodiesterase-type-5-inhibitor-for-erectile-dysfunction
#9
Sertan Öntepeli, Nuray Bayar Muluk, Devrim Tuğlu, Timuçin Şipal
We conducted a prospective study of transient evoked otoacoustic emissions (TEOAEs) and distortion-product otoacoustic emissions (DPOAEs) in men who were taking an oral phosphodiesterase type 5 (PDE5) inhibitor for erectile dysfunction. Our study group was made up of 30 men (60 ears), aged 34 to 60 years (mean: 50.9). They were randomly divided into three groups; 10 men were given sildenafil (Viagra) at 50 mg twice a week, 10 were given tadalafil (Cialis) at 20 mg twice a week, and 10 were given vardenafil (Levitra) at 20 mg twice a week...
July 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28668627/vigabatrin-lacks-proarrhythmic-potential-results-from-a-thorough-qt-qtc-study-in-healthy-volunteers
#10
Dwain Tolbert, Susan Reid, Stuart Harris, Ihor Bekersky
PURPOSE: A thorough QT study was performed to assess the proarrhythmic potential of vigabatrin, an antiepileptic drug approved in the United States for the treatment of infantile spasms and refractory complex partial seizures. METHODS: In this Phase I, randomized, double-blind, placebo- and active-controlled (moxifloxacin), 4-sequence, crossover study conducted at a single center, healthy participants received 1 of 4 randomly assigned treatments: 3.0g vigabatrin solution (therapeutic dose) and 1 moxifloxacin placebo tablet; 6...
June 28, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28668289/foley-catheterisation-versus-oral-misoprostol-for-induction-of-labour-in-hypertensive-women-in-india-inform-a-multicentre-open-label-randomised-controlled-trial
#11
Shuchita Mundle, Hillary Bracken, Vaishali Khedikar, Jayashree Mulik, Brian Faragher, Thomas Easterling, Simon Leigh, Paul Granby, Alan Haycox, Mark A Turner, Zarko Alfirevic, Beverly Winikoff, Andrew D Weeks
BACKGROUND: Between 62 000 and 77 000 women die annually from pre-eclampsia and eclampsia. Prompt delivery, preferably by the vaginal route, is vital for good maternal and neonatal outcomes. Two low-cost interventions-low-dose oral misoprostol tablets and transcervical Foley catheterisation-are already used in low-resource settings. We aimed to compare the relative risks and benefits of these interventions. METHODS: We undertook this multicentre, open-label, randomised controlled trial in two public hospitals in Nagpur, India...
August 12, 2017: Lancet
https://www.readbyqxmd.com/read/28633774/treatment-of-chronic-plantar-fasciitis-with-noninvasive-interactive-neurostimulation-a-prospective-randomized-controlled-study
#12
Cristina Razzano, Stefano Carbone, Massimiliano Mangone, M Raffaella Iannotta, Alessandro Battaglia, Valter Santilli
The initial treatment of plantar fasciitis should be conservative, with most cases responding to standard physiotherapy, nonsteroidal anti-inflammatory drugs (NSAIDs), heel pads, and stretching. In cases of chronic refractory symptoms, more invasive treatment could be necessary. Noninvasive interactive neurostimulation (NIN) is a form of electric therapy that works by locating areas of lower skin impedance. The objective of the present prospective randomized controlled study was to evaluate whether the use of NIN for chronic plantar fasciitis could result in greater improvement in a foot functional score, lower levels of reported pain, reduced patient consumption of NSAIDs, and greater patient satisfaction compared with electric shockwave therapy in patients without a response to standard conservative treatment...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28578607/abiraterone-plus-prednisone-in-metastatic-castration-sensitive-prostate-cancer
#13
RANDOMIZED CONTROLLED TRIAL
Karim Fizazi, NamPhuong Tran, Luis Fein, Nobuaki Matsubara, Alfredo Rodriguez-Antolin, Boris Y Alekseev, Mustafa Özgüroğlu, Dingwei Ye, Susan Feyerabend, Andrew Protheroe, Peter De Porre, Thian Kheoh, Youn C Park, Mary B Todd, Kim N Chi
BACKGROUND: Abiraterone acetate, a drug that blocks endogenous androgen synthesis, plus prednisone is indicated for metastatic castration-resistant prostate cancer. We evaluated the clinical benefit of abiraterone acetate plus prednisone with androgen-deprivation therapy in patients with newly diagnosed, metastatic, castration-sensitive prostate cancer. METHODS: In this double-blind, placebo-controlled, phase 3 trial, we randomly assigned 1199 patients to receive either androgen-deprivation therapy plus abiraterone acetate (1000 mg daily, given once daily as four 250-mg tablets) plus prednisone (5 mg daily) (the abiraterone group) or androgen-deprivation therapy plus dual placebos (the placebo group)...
July 27, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28507935/phospholipid-complex-technique-for-superior-bioavailability-of-phytoconstituents
#14
REVIEW
Kattamanchi Gnananath, Kalakonda Sri Nataraj, Battu Ganga Rao
Phytoconstituents have been utilized as medicines for thousands of years, yet their application is limited owing to major hurdles like deficit lipid solubility, large molecular size and degradation in the gastric environment of gut. Recently, phospholipid-complex technique has unveiled in addressing these stumbling blocks either by enhancing the solubilizing capacity or its potentiating ability to pass through the biological membranes and it also protects the active herbal components from degradation. Hence, this phospholipid-complex-technique can enable researchers to deliver the phytoconstituents into systemic circulation by using certain conventional dosage forms like tablets and capsules...
April 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28507605/diclofenac-potassium-for-oral-solution-cambia-%C3%A2-in-the-acute-management-of-a-migraine-attack-clinical-evidence-and-practical-experience
#15
REVIEW
Shivang Joshi, Alan M Rapoport
Migraine headache affects about 12% of Western populations and is the third most common disease worldwide (sixth in terms of disability). In 1993, triptans were introduced in the United States as a new treatment for managing migraine attacks, but their use is limited by lack of response and safety concerns in some patients. Treatment options for patients with migraine who fail or cannot tolerate triptans include switching to another medication or adding an adjunctive medication. Desirable characteristics reported by patients for acute treatment of migraine attacks include complete pain relief, fast onset of action, and no pain recurrence...
April 2017: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/28464867/a-community-based-cluster-randomised-controlled-trial-to-evaluate-the-effectiveness-of-different-bundles-of-nutrition-specific-interventions-in-improving-mean-length-for-age-z-score-among-children-at-24%C3%A2-months-of-age-in-rural-bangladesh-study-protocol
#16
Sk Masum Billah, Tarana E Ferdous, Mohd Anisul Karim, Michael J Dibley, Shahreen Raihana, Md Moinuddin, Nuzhat Choudhury, Tahmeed Ahmed, D M Emdadul Hoque, Purnima Menon, Shams El Arifeen
BACKGROUND: Prevalence of stunting among under-five children in Bangladesh is 36%, varying with geographic and socio-economic characteristics. Previously, research groups statistically modelled the effect of 10 individual nutrition-specific interventions targeting the critical first 1000 days of life from conception, on lives saved and costs incurred in countries with the highest burden of stunted children. However, primary research on the combined effects of these interventions is limited...
May 2, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28463028/different-analgesics-prior-to-intrauterine-device-insertion-is-there-any-evidence-of-efficacy
#17
Nabih I Elkhouly, Mohammad Ahmed Maher
OBJECTIVES: The aims of this study were to compare three different interventions to reduce pain related to insertion of the intrauterine device (IUD), namely, lidocaine, misoprostol and a non-steroidal anti-inflammatory drug, against a placebo, and to assess the advantages of one drug over another, if any. METHODS: This was an open-label randomised placebo-controlled trial of 200 women assigned to receive one of the following medications prior to IUD insertion: 10 ml 1% lidocaine paracervical block, 400 μg oral misoprostol, oral naproxen or placebo tablets...
May 2, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28386442/polarimetry-of-pinctada-fucata-nacre-indicates-myostracal-layer-interrupts-nacre-structure
#18
Rebecca A Metzler, Joshua A Jones, Anthony J D'Addario, Enrique J Galvez
The inner layer of many bivalve and gastropod molluscs consists of iridescent nacre, a material that is structured like a brick wall with bricks consisting of crystalline aragonite and mortar of organic molecules. Myostracal layers formed during shell growth at the point of muscle attachment to the shell can be found interspersed within the nacre structure. Little has been done to examine the effect the myostracal layer has on subsequent nacre structure. Here we present data on the structure of the myostracal and nacre layers from a bivalve mollusc, Pinctada fucata...
February 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28352615/results-of-a-randomized-prospective-double-dummy-double-blind-trial-to-compare-efficacy-and-safety-of-a-herbal-combination-containing-tropaeoli-majoris-herba-and-armoraciae-rusticanae-radix-with-co-trimoxazole-in-patients-with-acute-and-uncomplicated-cystitis
#19
Rainer Stange, Berthold Schneider, Uwe Albrecht, Valentina Mueller, Joerg Schnitker, Andreas Michalsen
OBJECTIVES: To demonstrate non-inferiority of an herbal combination (horseradish root and nasturtium herb) to an antibiotic (co-trimoxazole) in acute uncomplicated cystitis. DESIGN: Randomized, prospective, double-blind, double-dummy, multicenter, phase III clinical study, using block randomization of 4 blocks (size 2). SETTING: Twenty-six centers in Germany, from May 2011 to June 2013. PARTICIPANTS: Adult patients (median age, 38...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28293188/evidence-for-narrow-transfer-after-short-term-cognitive-training-in-older-adults
#20
Dustin J Souders, Walter R Boot, Kenneth Blocker, Thomas Vitale, Nelson A Roque, Neil Charness
The degree to which "brain training" can improve general cognition, resulting in improved performance on tasks dissimilar from the trained tasks (transfer of training), is a controversial topic. Here, we tested the degree to which cognitive training, in the form of gamified training activities that have demonstrated some degree of success in the past, might result in broad transfer. Sixty older adults were randomly assigned to a gamified cognitive training intervention or to an active control condition that involved playing word and number puzzle games...
2017: Frontiers in Aging Neuroscience
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