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https://www.readbyqxmd.com/read/28340277/immunomodulatory-and-neuroprotective-effect-of-cryopreserved-allogeneic-mesenchymal-stem-cells-on-spinal-cord-injury-in-rats
#1
I R Rosado, P H Carvalho, E G L Alves, T M Tagushi, J L Carvalho, J F Silva, M S L Lavor, K M Oliveira, R Serakides, A M Goes, E G Melo
This study aimed to evaluate the immunomodulatory and neuroprotective effects of allogeneic and cryopreserved mesenchymal stem cells (MSCs) on spinal cord injury. A total of 120 rats were distributed into the following groups: negative control (NC) - without injury, positive control (PC) - with injury without treatment, and group treated with MSC (GMSC) - with injury and treated. Motor function was evaluated by the BBB test at 24, 48, and 72 h and at 8 and 21 postoperative days. Spinal cords were evaluated by histopathology and immunohistochemistry to determine the expression of CD68, NeuN, and GFAP...
March 22, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28339522/influence-of-postbiotic-rg14-and-inulin-combination-on-cecal-microbiota-organic-acid-concentration-and-cytokine-expression-in-broiler-chickens
#2
K Y Kareem, T C Loh, H L Foo, S A Asmara, H Akit
This study examined the effects of different combinations of inulin and postbiotics RG14 on growth performance, cecal microbiota, volatile fatty acids (VFA), and ileal cytokine expression in broiler chickens. Two-hundred-and sixteen, one-day-old chicks were allocated into 6 treatment groups, namely, a basal diet (negative control, NC), basal diet + neomycin and oxytetracycline (positive control, PC), T1 = basal diet + 0.15% postbiotic RG14 + 1.0% inulin, T2 = basal diet + 0.3% postbiotic RG14 + 1.0% inulin, T3 = basal diet + 0...
October 6, 2016: Poultry Science
https://www.readbyqxmd.com/read/28339305/development-of-anxiety-depression-and-health-related-quality-of-life-in-oncology-patients-without-initial-symptoms-according-to-the-hospital-anxiety-and-depression-scale-a-comparative-study
#3
Annika Thalén-Lindström, Bengt Glimelius, Birgitta Johansson
BACKGROUND: Depression and anxiety are associated with decreased health-related quality of life (HRQoL). The knowledge about the development of anxiety, depression and HRQoL in cancer patients without depression or anxiety, that is initially scoring as non-cases (cutoff <8) according to the Hospital Anxiety and Depression Scale (HADS), is sparse. The objectives were: (1) to evaluate changes in anxiety, depression and HRQoL over 6 months in two independent cohorts of oncology patients initially scoring as non-cases by the HADS, (2) to compare stable non-case patients with the general population regarding HRQoL and (3) to explore the outcomes using >4 rather than >7 as cutoff on any of HADS subscales...
March 24, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28335495/brain-derived-neurotrophic-factor-loaded-ps80-pbca-nanocarrier-for-in-vitro-neural-differentiation-of-mouse-induced-pluripotent-stem-cells
#4
Chiu-Yen Chung, Martin Hsiu-Chu Lin, I-Neng Lee, Tsong-Hai Lee, Ming-Hsueh Lee, Jen-Tsung Yang
Brain derived neurotrophic factor (BDNF) can induce neural differentiation in stem cells and has the potential for repair of the nervous system. In this study, a polysorbate 80-coated polybutylcyanoacrylate nanocarrier (PS80 PBCA NC) was constructed to deliver plasmid DNAs (pDNAs) containing BDNF gene attached to a hypoxia-responsive element (HRE-cmvBDNF). The hypoxia-sensing mechanism of BDNF expression and inductiveness of the nano-formulation on mouse induced pluripotent stem cells (iPSCs) to differentiate into neurons following hypoxia was tested in vitro with immunofluorescent staining and Western blotting...
March 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28335210/application-of-l-aspartic-acid-capped-zns-mn-colloidal-nanocrystals-as-a-photosensor-for-the-detection-of-copper-ii-ions-in-aqueous-solution
#5
Jungho Heo, Cheong-Soo Hwang
Water-dispersible ZnS:Mn nanocrystals (NCs) were synthesized by capping the surface with polar L-aspartic acid (Asp) molecules. The obtained ZnS:Mn-Asp NC product was optically and physically characterized using the corresponding spectroscopic methods. The ultra violet-visible (UV-VIS) absorption spectrum and photoluminescence (PL) emission spectrum of the NCs showed broad peaks at 320 and 590 nm, respectively. The average particle size measured from the obtained high resolution-transmission electron microscopy (HR-TEM) image was 5...
April 27, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335091/assessment-of-genetic-diversity-and-phylogenetic-relationships-of-korean-native-chicken-breeds-using-microsatellite-markers
#6
Joo Hee Seo, Jun-Heon Lee, Hong Sik Kong
In this study, the genetic diversity and phylogenetic relationships of 445 Korean native chickens from five different breeds(Korean Native Chicken (NC), Leghorn (LH), Cornish (CS), Rhode Island Red (RIR), and Hanhyup(HH) commercial line) were studied by performing genotyping using 20 microsatellite (MS) markers. Among the 20 MS markers selected for the genotyping, the number of alleles ranged from 5 (ADL0268) to 20 (MCW0127). The observed heterozygosity (Hobs) ranged from 0.349 (GCT0016) to 0.683 (MCW0145)...
March 21, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28334456/a-systematic-review-of-combined-student-and-parent-based-programs-to-prevent-alcohol-and-other-drug-use-among-adolescents
#7
REVIEW
Nicola C Newton, Katrina E Champion, Tim Slade, Cath Chapman, Lexine Stapinski, Ina Koning, Zoe Tonks, Maree Teesson
ISSUES: Alcohol and other drug use among adolescents is a serious concern, and effective prevention is critical. Research indicates that expanding school-based prevention programs to include parenting components could increase prevention outcomes. This paper aims to identify and describe existing combined student- and parent-based programs for the prevention of alcohol and other drug use to evaluate the efficacy of existing programs. APPROACH: The PsycINFO, Medline, Central Register of Controlled trials and Cochrane databases were searched in April 2015 and additional articles were obtained from reference lists...
March 23, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28334316/insecticide-resistance-of-several-field-collected-german-cockroach-dictyoptera-blattellidae-strains
#8
Xiaoyan Wu, Arthur G Appel
German cockroaches, Blattella germanica (L.), remain one of the most difficult indoor insect species to control because of its ability to develop resistance to insecticides. The toxicity and resistance levels of five technical-grade insecticides (permethrin, chlorpyrifos, propoxur, imidacloprid, and fipronil) were determined for adult males of seven strains of the German cockroach, a laboratory-reared susceptible strain (S) and six field-collected strains (B, D, E, G, H, and I). Using topical application methods, fipronil was the most toxic insecticide to all seven strains...
March 8, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28333946/structural-and-functional-connectional-fingerprints-in-mild-cognitive-impairment-and-alzheimer-s-disease-patients
#9
Seong-Jin Son, Jonghoon Kim, Hyunjin Park
Regional volume atrophy and functional degeneration are key imaging hallmarks of Alzheimer's disease (AD) in structural and functional magnetic resonance imaging (MRI), respectively. We jointly explored regional volume atrophy and functional connectivity to better characterize neuroimaging data of AD and mild cognitive impairment (MCI). All data were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. We compared regional volume atrophy and functional connectivity in 10 subcortical regions using structural MRI and resting-state functional MRI (rs-fMRI)...
2017: PloS One
https://www.readbyqxmd.com/read/28333841/audit-of-ca125-follow-up-after-first-line-therapy-for-ovarian-cancer
#10
Daniel Krell, Fran Said Battistino, Sarah Benafif, Lochani Ganegoda, Marcia Hall, Gordon J S Rustin
AIMS: The Medical Research Council OVO5/EORTC 55955 trial showed that patients in remission after first-line therapy for ovarian cancer did not benefit from routine measurement of CA125 during follow-up. Since the presentation of these results, we have counseled patients about the options for follow-up and provided them with an information leaflet about the trial results and the symptoms that should prompt an early appointment and CA125 measurement. We present an audit of practice after the presentation of those results...
March 23, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28333763/inflammatory-status-and-lung-function-predict-mortality-in-lung-cancer-screening-participants
#11
Ugo Pastorino, Daniele Morelli, Alfonso Marchianò, Stefano Sestini, Paola Suatoni, Francesca Taverna, Mattia Boeri, Gabriella Sozzi, Anna Cantarutti, Giovanni Corrao
Low-dose computed tomography (LDCT) screening trials have based their risk selection algorithm on age and tobacco exposure, but never on pulmonary risk-related biomarkers. In the present study, the baseline inflammatory status, measured by C-reactive protein (CRP) level, and lung function, measured by forced expiratory volume in 1 s (FEV1), were tested as independent predictors of all-cause mortality in LDCT-screening participants. Between 2000 and 2010, 4413 volunteers were enrolled in two LDCT-screening trials, with evaluable baseline CRP and FEV1 values: 2037 were included in the discovery set and 2376 were included in the validation set...
March 23, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28333760/antibiotic-associated-apoptotic-enterocolitis-in-the-absence-of-a-defined-pathogen-the-role-of-intestinal-microbiota-depletion
#12
Philipp Wurm, Walter Spindelboeck, Robert Krause, Johannes Plank, Gottfried Fuchs, Mina Bashir, Wolfgang Petritsch, Bettina Halwachs, Cord Langner, Christoph Högenauer, Gregor Gorkiewicz
OBJECTIVE: Antibiotic therapy is a major risk factor for the development of diarrhea and colitis with varying severity. Often the origin of antibiotic-associated gastrointestinal deterioration remains elusive and no specific infectious agents could be discerned. PATIENTS: We represent three cases of intractable high-volume diarrhea associated with combined antibiotic and steroid therapy in critically ill patients not fitting into established disease entities. Cases presented with severe apoptotic enterocolitis resembling acute intestinal graft-versus-host-disease...
March 22, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28333715/noninvasive-imaging-of-stored-red-blood-cell-transfusion-aggravating-sepsis-induced-liver-injury-associated-with-increased-activation-of-m1-polarized-kupffer-cells
#13
Tao Wu, Lei Wang, Jie An, Chao Y Wu, Yue Wang, Lu Qian, Jun Zhou, Yu L Zhang, Qian Q Zhou, Xiao H Wang, Hua F Wang, Qiu X Fu, Lin S Zhan
Liver injury has a critical effect on the severity and outcome of sepsis. The impact of stored RBCs on the pathogenesis of sepsis-associated hepatic injury is not well understood. Therefore, to investigate the effects of stored-RBC transfusion on sepsis-induced liver damage as well as the associated mechanism, we constructed a sepsis mouse model enabling non-invasive imaging of bacterial infection caused by Pseudomonas aeruginosa, a common gram-negative respiratory pathogen. We showed that transfusions with stored RBCs enhanced sepsis-induced liver injury in vivo, and liver injury exacerbated the severity of sepsis and decreased survival in P...
March 22, 2017: Shock
https://www.readbyqxmd.com/read/28333074/assessment-of-the-anti-hyperglycaemic-anti-inflammatory-and-antioxidant-activities-of-the-methanol-extract-of-moringa-oleifera-in-diabetes-induced-nephrotoxic-male-wistar-rats
#14
Elizabeth I Omodanisi, Yapo G Aboua, Oluwafemi O Oguntibeju
Diabetes mellitus is an endocrine disease of multiple aetiologies in insulin secretion. A deficiency in insulin results in hyperglycemia with metabolic disturbances of biomolecules. Moringa oleifera (MO) is endemic in the tropics with a variety of ethnomedicinal importance. The leaf of this plant has been reported to possess antioxidant and medicinal properties that may be helpful in the treatment and management of diabetes and its associated complications. Diabetes was induced intraperitoneally in rats by a single dose of streptozotocin (55 mg/kg) and treated with methanolic extract of Moringa oleifera (250 mg/kg b...
March 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28332856/association-between-serum-gamma-glutamyl-transferase-and-serum-uric-acid-levels-in-chinese-females-a-cross-sectional-study
#15
Zhao Ya, Liu Fei, Zeng Yue, Liu Dan, Lin Neng-Bo, Luo Yi, Miao Ying, Wan Qin
OBJECTIVE: To investigate the association between serum gamma-glutamyl transferase (GGT) levels and serum uric acid levels in middle-aged and elderly Chinese females. METHODS: A cross-sectional population survey was performed in Luzhou, China (2014). Questionnaires, physical examinations and biochemical tests were conducted. Finally, we included 2486 females who were > 40 years old as participants. Multiple linear regression analysis was used to estimate the association of serum acid levels and other variables...
March 23, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28330709/microorganisms-present-on-peripheral-intravenous-needleless-connectors-in-the-clinical-environment
#16
Karen Slater, Marie Cooke, Michael Whitby, Fiona Fullerton, Joel Douglas, Jennine Hay, Claire Rickard
The aim of this study was to quantify culturable microorganisms on needleless connectors (NCs) attached to peripheral intravenous catheters in hospitalized adult medical patients. Half (50%) of 40 NCs were contaminated with microorganisms commonly found on the skin or mouth. Staphylococcus capitis and Staphylococcus epidermidis were most commonly isolated. Emergency department insertion and higher patient dependency were statistically associated with positive NC microorganism growth. These results reaffirm the need for NC decontamination prior to access...
March 20, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28328654/outcomes-for-children-receiving-noninvasive-ventilation-as-the-first-line-mode-of-mechanical-ventilation-at-intensive-care-admission-a-propensity-score-matched-cohort-study
#17
Jenny V Morris, Padmanabhan Ramnarayan, Roger C Parslow, Sarah J Fleming
OBJECTIVES: To compare outcomes of children receiving noninvasive ventilation with those receiving invasive ventilation as first-line mode of mechanical ventilation following unplanned intensive care admission. DESIGN: Propensity score-matched cohort study analyzing data prospectively collected by the Pediatric Intensive Care Audit Network over 8 years (2007-2014). SETTING: Thirty-one PICUs in the United Kingdom and Ireland; twenty-one of whom submitted Pediatric Critical Care Minimum Dataset data for the entire study period...
March 21, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28328646/sensory-characterization-of-odors-in-used-disposable-absorbent-incontinence-products
#18
Heléne Widén, Susanne Alenljung, Ulla Forsgren-Brusk, Gunnar Hall
PURPOSE: The objectives of this study were to characterize the odors of used incontinence products by descriptive analysis and to define attributes to be used in the analysis. A further objective was to investigate to what extent the odor profiles of used incontinence products differed from each other and, if possible, to group these profiles into classes. SUBJECTS AND SETTING: Used incontinence products were collected from 14 residents with urinary incontinence living in geriatric nursing homes in the Gothenburg area, Sweden...
March 21, 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28328645/relationship-of-wound-ostomy-and-continence-certified-nurses-and-healthcare-acquired-conditions-in-acute-care-hospitals
#19
Diane K Boyle, Sandra Bergquist-Beringer, Emily Cramer
PURPOSE: The purpose of this study was to describe the (a) number and types of employed WOC certified nurses in acute care hospitals, (b) rates of hospital-acquired pressure injury (HAPI) and catheter-associated urinary tract infection (CAUTI), and (c) effectiveness of WOC certified nurses with respect to lowering HAPI and CAUTI occurrences. DESIGN: Retrospective analysis of data from National Database of Nursing Quality Indicators. SUBJECTS AND SETTINGS: The sample comprised 928 National Database of Nursing Quality Indicators (NDNQI) hospitals that participated in the 2012 NDNQI RN Survey (source of specialty certification data) and collected HAPI, CAUTI, and nurse staffing data during the years 2012 to 2013...
March 22, 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28328644/identification-of-key-odorants-in-used-disposable-absorbent-incontinence-products
#20
Gunnar Hall, Susanne Alenljung, Ulla Forsgren-Brusk
PURPOSE: The purpose of this study was to identify key odorants in used disposable absorbent incontinence products. DESIGN: Descriptive in vitro study SUBJECTS AND SETTING:: Samples of used incontinence products were collected from 8 residents with urinary incontinence living in geriatric nursing homes in the Gothenburg area of Sweden. Products were chosen from a larger set of products that had previously been characterized by descriptive odor analysis. METHODS: Pieces of the used incontinence products were cut from the wet area, placed in glass bottles, and kept frozen until dynamic headspace sampling of volatile compounds was completed...
March 22, 2017: Journal of Wound, Ostomy, and Continence Nursing
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