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JOURNAL ARTICLE
Nanda Yuli Rahmawati, Fadhil Ahsan, Budi Santoso, Alfin Firasy Mufid, Ashon Sa'adi, Sri Ratna Dwiningsih, Arif Tunjungseto, M Y Ardianta Widyanugraha
OBJECTIVES: Myeloid cell-derived factors contribute to the immunopathology of endometriosis. Soluble CD14 (sCD14), CD163 (sCD163), and MIF serves as in vivo markers of myeloid function. However, these soluble molecules are largely unexplored in women with endometriosis-related infertility cases. We investigated three soluble markers, namely sCD14, sCD163, and MIF, in cases of infertility associated with endometriosis and correlated its level to the stage of endometriosis. DESIGN: Eighty-seven women newly diagnosed with endometriosis or other benign gynecologic control cases linked to infertility were prospectively recruited and underwent diagnostic laparoscopy...
April 3, 2024: Gynecologic and Obstetric Investigation
#22
JOURNAL ARTICLE
Aleksandra Zyguła, Anna Sankiewicz, Agata Sakowicz, Ewa Dobrzyńska, Agnieszka Dakowicz, Grzegorz Mańka, Mariusz Kiecka, Robert Spaczynski, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Młodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Szczupak, Tomasz Kluza, Marek Kluza, Piotr Pierzyński, Cezary Wojtyla, Michal Lipa, Damian Warzecha, Miroslaw Wielgos, Krzysztof Cendrowski, Ewa Gorodkiewicz, Piotr Laudanski
BACKGROUND: The aim of this study was to analyze the concentration of leptin in peritoneal fluid and plasma and to assess their role as potential biomarkers in the diagnosis of endometriosis. MATERIALS & METHODS: Leptin adjusted for BMI (leptin/BMI ratio) was measured using surface plasmon resonance imaging (SPRI) biosensors. Patients with suspected endometriosis were included in the study. Plasma was collected from 70 cases, and peritoneal fluid from 67 cases...
2024: Frontiers in Endocrinology
#23
JOURNAL ARTICLE
Ning Huang, Lixue Chen, Zhiqiang Yan, Hongbin Chi, Jie Qiao
BACKGROUND: Cumulative live birth rate (CLBR) is considered as the most important endpoint for assessing the probability of having a baby in a complete in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment cycle. Many previous studies have focused on the association between thyroid autoimmunity (TAI) and live birth rate after first embryo transfer cycle, however, evidence on whether the presence of TAI affects the CLBR is lacking. The purpose of this study is to investigate the impact of TAI on the CLBR in a complete IVF/ICSI cycle...
April 2, 2024: BMC Pregnancy and Childbirth
#24
JOURNAL ARTICLE
Fabia Pigatti Silva, Daniela Angerame Yela, Melissa de Barros Meneguetti, Flavia Torelli, Luciano Gibran, Cristina Laguna Benetti-Pinto
PURPOSE: To evaluate the quality of life, sexual function, anxiety, and depression of women with endometriosis according to pain symptoms and infertility. METHODS: This cross-sectional multicenter study included 229 women with endometriosis followed up at a tertiary hospital in Campinas, a tertiary hospital in São Paulo, and a reproductive medicine clinic in Campinas from 2018 to 2021. The women were divided into four groups according to the presence of pain symptoms and infertility...
April 2, 2024: Archives of Gynecology and Obstetrics
#25
JOURNAL ARTICLE
Yanlin Su, Wencai Tian, Li Cheng, Ling Yin, Xiaoxia He, Xin Wei
INTRODUCTION: Endometriosis (EMs), manifested by pain and infertility, is a chronic inflammatory disease. The precise pathophysiology of this disease remains uncertain. Insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1) and polypyrimidine tract-binding protein 1 (PTBP1) have both been found to regulate proliferation, apoptosis, and invasion. This study aimed to investigate the effects of IGF2BP1/PTBP1 in treating EMs. MATERIALS AND METHODS: qRT-PCR and western blotting were employed to quantify IGF2BP1 and PTBP1 expression in six patients with EMs (mean age 33...
April 2, 2024: Folia Histochemica et Cytobiologica
#26
Samvida S Venkatesh, Laura B L Wittemans, Duncan S Palmer, Nikolas A Baya, Teresa Ferreira, Barney Hill, Frederik Heymann Lassen, Melody J Parker, Saskia Reibe, Ahmed Elhakeem, Karina Banasik, Mie T Bruun, Christian Erikstrup, Bitten A Jensen, Anders Juul, Christina Mikkelsen, Henriette S Nielsen, Sisse R Ostrowski, Ole B Pedersen, Palle D Rohde, Erik Sorensen, Henrik Ullum, David Westergaard, Asgeir Haraldsson, Hilma Holm, Ingileif Jonsdottir, Isleifur Olafsson, Thora Steingrimsdottir, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Jessica Figueredo, Minna K Karjalainen, Anu Pasanen, Benjamin M Jacobs, Nikki Hubers, Margaret Lippincott, Abigail Fraser, Deborah A Lawlor, Nicholas J Timpson, Mette Nyegaard, Kari Stefansson, Reedik Magi, Hannele Laivuori, David A van Heel, Dorret I Boomsma, Ravikumar Balasubramanian, Stephanie B Seminara, Yee-Ming Chan, Triin Laisk, Cecilia M Lindgren
Genome-wide association studies (GWASs) may help inform treatments for infertility, whose causes remain unknown in many cases. Here we present GWAS meta-analyses across six cohorts for male and female infertility in up to 41,200 cases and 687,005 controls. We identified 21 genetic risk loci for infertility ( P ≤5E-08), of which 12 have not been reported for any reproductive condition. We found positive genetic correlations between endometriosis and all-cause female infertility ( r g =0.585, P =8.98E-14), and between polycystic ovary syndrome and anovulatory infertility ( r g =0...
March 20, 2024: medRxiv
#27
JOURNAL ARTICLE
Ling Wang, Chenhan Zhao, Qin Zhang
In last twenty years, the cesarean section rate has been rising in China, leading to an increased prevalence of cesarean scar defect (CSD) and secondary infertility. CSD decreases receptivity of endometrium, induces adenomyosis and endometriosis, disrupts uterine micro-environment, causes difficulty of embryo transplant operation and further pregnancy complications. For women undergoing assisted reproductive technology (ART), CSD significantly reduces embryo implantation rate, clinical pregnancy rate and live birth rate...
March 30, 2024: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
#28
JOURNAL ARTICLE
Shana Guo, Qizhen Chen, Jiaqi Liang, Huanmei Wu, Li Li, Yanqiu Wang
Endometriosis (EMT) -related infertility has been a challenge for clinical research. Many studies have confirmed that abnormal alterations in the immune microenvironment and glycolysis are instrumental in causing EMT-related infertility. Recently, our research team identified several key glycolysis-immune-related genes in the endometrial cells of EMT patients. This study aimed to further investigate the expression patterns of pyruvate dehydrogenase kinase 3 (PDK3), glypican-3 (GPC3), and alcohol dehydrogenase 6 (ADH6), which are related to glycolysis and immunity, in the follicular microenvironment of infertile patients with EMT using enzyme-linked immunosorbent assay (ELISA) and quantitative real-time polymerase chain reaction (qRT-PCR) assays...
April 1, 2024: Reproductive Sciences
#29
REVIEW
Ayurvedic Herbal Medicines: A Literature Review of Their Applications in Female Reproductive Health.
Srihita Patibandla, Joshua J Gallagher, Laasya Patibandla, Ali Z Ansari, Shayaan Qazi, Samuel F Brown
Ayurveda, an ancient holistic and personalized healing system originating from the Indian subcontinent, has been gaining increasing attention as a complementary and alternative medical practice for treating various health conditions, including those related to women's reproductive well-being. This comprehensive literature review examines a wide array of experimental and clinical studies exploring the diverse facets of Ayurvedic interventions in addressing issues such as menstrual irregularities, polycystic ovary syndrome (PCOS), infertility, and menopausal symptoms...
February 2024: Curēus
#30
REVIEW
Alireza Omidvar-Mehrabadi, Fateme Ebrahimi, Mehdi Shahbazi, Mousa Mohammadnia-Afrouzi
Numerous factors (including immunological, congenital, hormonal, and morphological disorders) can lead to infertility. In this regard, 3 specific diseases associated with infertility are discussed in this review study (i.e., polycystic ovary syndrome [PCOS], endometriosis [EMS], and unexplained infertility [UI]). PCOS is a common endocrine disorder characterized by chronic low-grade inflammation, and EMS is a benign disease characterized by the presence of ectopic endometrial tissue. UI refers to couples who are unable to conceive for no known reason...
June 2024: Cytokine
#31
JOURNAL ARTICLE
Aynur Azizova, Turkmen Turan Ciftci, Murat Gultekin, Emre Unal, Okan Akhan, Gurkan Bozdag, Devrim Akinci
PURPOSE: To provide technical guidance on applying catheter-directed and needle-directed ethanol sclerotherapy for endometriomas and present the results of these sclerotherapy methods. MATERIALS AND METHODS: From January 2015 to March 2021, the results of the patients with symptomatic ovarian endometriomas who underwent needle-directed or catheter-directed sclerotherapy were evaluated, retrospectively. The decision to apply which sclerotherapy technique was made during the procedure for each patient considering the following factors: cyst size, cyst location, cyst viscosity, and tissue rigidity...
March 29, 2024: Cardiovascular and Interventional Radiology
#32
JOURNAL ARTICLE
X Zheng, X Yu, X Xie, G Lyu, J Niu, X Li, H Chen, A Watrelot, J Guan
BACKGROUND: Subtle distal fallopian tube abnormalities are a group of diseases characterised by small variations in tubal anatomy. The clinical significance of these abnormalities need to be studied. OBJECTIVES: The purpose of this multicentre prospective observational study was to investigate whether subtle distal fallopian tube abnormalities are related to infertility and endometriosis. MATERIALS AND METHODS: The investigation was carried out in five medical centres in China and France from February to July 2021 and included reproductive-age patients who underwent gynaecological laparoscopy...
March 2024: Facts, Views & Vision in ObGyn
#33
JOURNAL ARTICLE
Haiying Huang, Yanshan Lin, Huayang Ye
BACKGROUND: While endometriosis is commonly perceived as a benign gynecological condition, its aggressive biological behavior underscores the critical importance of effective postoperative management. Our research is driven by the ultimate goal of improving postoperative recovery, reducing recurrence rates, and enhancing the overall well-being and fertility of individuals affected by endometriosis. To achieve these objectives, this study conducts a systematic assessment of the therapeutic efficacy of traditional Chinese medicine (TCM) in the context of endometriosis through a comprehensive meta-analysis...
March 29, 2024: Alternative Therapies in Health and Medicine
#34
JOURNAL ARTICLE
Tao Wang, Mei Ji, Jing Sun
BACKGROUND: Endometriosis is one of the most common benign gynecological diseases and is characterized by chronic pain and infertility. Endoplasmic reticulum (ER) stress is a cellular adaptive response that plays a pivotal role in many cellular processes, including malignant transformation. However, whether ER stress is involved in endometriosis remains largely unknown. Here, we aimed to explore the potential role of ER stress in endometriosis, as well as its diagnostic value. METHODS: We retrieved data from the Gene Expression Omnibus (GEO) database...
2024: PeerJ
#35
REVIEW
Ferdinando Antonio Gulino, Sara Occhipinti, Carla Ettore, Giosuè Giordano Incognito, Emanuele Russo, Francesco Giuseppe Cannone, Giuseppe Ettore
Robert's uterus is a rare Müllerian duct anomaly (MDA) characterized by complete asymmetric septum dividing uterine cavity into two non-communicating parts. This study offers insights into diagnosing and management of this condition in a young patient, and a systematic literature review. The review included 19 studies from 2013 to 2023. 11.4% of women reported a history of miscarriage and 5.7% primary infertility. Dysmenorrhea was the most frequent symptom (54.3%), and 14.3% of patients had a coexisting endometriosis...
March 28, 2024: Journal of Clinical Ultrasound: JCU
#36
JOURNAL ARTICLE
Reza Nafisi Moghadam, Fatemeh Tamizi, Seid Kazem Razavi Ratki, Amin Nafisi Moghadam, Atiyeh Javaheri, Nasim Namiranian
BACKGROUND: Endometriosis is a multifocal gynecologic disorder during the fertility period in women. Magnetic resonance imaging (MRI) is an important diagnostic modality for this disease and can either be used alone or along with transvaginal ultrasonography. OBJECTIVE: This study aims to compare the accuracy of pelvis MRI in pelvic deep endometriosis with laparoscopic findings in women referred to Shahid Sadoughi hospital in one year. MATERIALS AND METHODS: This cross-sectional study was conducted on 40 women suspicious of endometriosis who referred to Shahid Sadoughi hospital, Yazd, Iran from November 2020-2021...
January 2024: International Journal of Reproductive Biomedicine (Yazd, Iran)
#37
REVIEW
Shaoliang Yang, Haiyan Wang, Dajin Li, Mingqing Li
Endometriosis is a common estrogen-dependent condition that impacts 8-10% of women in their reproductive age, resulting in notable pain, morbidity, and infertility. Despite extensive research endeavors, the precise cause of endometriosis remains elusive, and the mechanisms contributing to its associated infertility are still not well comprehended. Natural killer (NK) cells, vital innate immune cells crucial for successful pregnancy, have been investigated for their potential involvement in the pathogenesis of endometriosis...
March 16, 2024: International Journal of Molecular Sciences
#38
JOURNAL ARTICLE
Stefano Di Michele, Silvia Bramante, Stefano Angioni, Michela Bernassola, Tommaso De Vita, Daniela Anna Iaccarino, Luca Giannoni, Maurizio Rosati
Background : The validation of laser usage during laparoscopic procedures, notably by Camran Nezhat in the late 1980s, has been significant. Lasers offer precision and depth control in tissue vaporization without bleeding. Surgical intervention remains central in managing endometriosis-associated pain and infertility, especially for patients unresponsive to hormonal therapy. Methods : This retrospective cohort study included 200 patients with superficial peritoneal endometriosis (SPE) who underwent laparoscopic laser vaporization...
March 17, 2024: Journal of Clinical Medicine
#39
JOURNAL ARTICLE
Angelika Bogusz, Magdalena Górnicka
Endometriosis is a chronic gynecological disease characterized by ectopic endometrial tissue outside the uterus that can cause chronic pain, dysmenorrhea, fatigue, and infertility. The aim of this study was to assess diet quality and nutritional knowledge of women with endometriosis. A questionnaire was used to collect data on lifestyle, dietary habits and nutritional knowledge from 90 women. More than 80% of women with endometriosis (82.2%) confirmed that diet and lifestyle are related to the progression of endometriosis...
March 17, 2024: Healthcare (Basel, Switzerland)
#40
REVIEW
Julie Fiscus, Éloïse Fraison, Lucie Renault, Bruno Salle, Baptiste Panthu, Elsa Labrune
Metabolomics offers new methods to identify biomarkers for oocyte and embryo quality, and for a better understanding of the physiopathology of infertility. This review investigated the latest findings regarding metabolome-derived biomarkers in follicular fluid of women with the most common types of infertility, and the potential impact on reproductive medicine outcomes. PubMed was searched for publications on metabolomics and human follicular fluid, and key biomarkers, kinetics and relationships with infertility diseases were identified...
December 5, 2023: Reproductive Biomedicine Online
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