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endometriosis & infertility

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https://www.readbyqxmd.com/read/28292651/human-exposure-to-endocrine-disrupting-chemicals-effects-on-the-male-and-female-reproductive-systems
#1
REVIEW
Stavros Sifakis, Vasilis P Androutsopoulos, Aristeidis M Tsatsakis, Demetrios A Spandidos
Endocrine disrupting chemicals (EDCs) comprise a group of chemical compounds that have been examined extensively due to the potential harmful effects in the health of human populations. During the past decades, particular focus has been given to the harmful effects of EDCs to the reproductive system. The estimation of human exposure to EDCs can be broadly categorized into occupational and environmental exposure, and has been a major challenge due to the structural diversity of the chemicals that are derived by many different sources at doses below the limit of detection used by conventional methodologies...
March 6, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28288431/non-art-pregnancy-predictive-factors-in-infertile-patients-with-peritoneal-superficial-endometriosis
#2
J Boujenah, I Cedrin-Durnerin, C Herbemont, C Sifer, C Poncelet
OBJECTIVE: To study the predictive factors for non-ART pregnancy in infertile women after laparoscopic diagnosis and surgery for isolated superficial peritoneal endometriosis (SUP). STUDY DESIGN: Retrospective observational study from January-2004 to December-2015 in a tertiary care university hospital and Assisted Reproductive Technology (ART) centre. Infertile women with laparoscopic surgery for SUP (with histologic diagnosis) were included. The surgical treatment was followed by spontaneous fertility or post-operative ovarian stimulation (pOS) using superovulation (gonadotrophins)±Intra Uterine Insemination (IUI)...
March 7, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28286987/endometriosis-after-menopause-physiopathology-and-management-of-an-uncommon-condition
#3
I Streuli, H Gaitzsch, J-M Wenger, P Petignat
Endometriosis is a hormone-dependent inflammatory disease that is usually characterized by infertility and pain symptoms. This disease mainly occurs during the reproductive years and is rarely diagnosed after menopause. We discuss the physiopathology of this condition after menopause as well as treatment options and the risk of malignant transformation. Occurrence or progression of postmenopausal endometriosis lesions could be related to extra-ovarian production of estrogen by endometriosis lesions and adipose tissue, which becomes the major estrogen-producing tissue after menopause...
April 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28283302/perfluoroalkyl-substances-and-endometriosis-related-infertility-in-chinese-women
#4
Bin Wang, Rongrong Zhang, Fan Jin, Hangying Lou, Yuchan Mao, Wenting Zhu, Wei Zhou, Ping Zhang, Jun Zhang
Endometriosis is one of the main causes for female infertility. Previous studies suggested that perfluoroalkyl substances (PFASs), a group of ubiquitous environmental chemicals with properties of endocrine disruption and reproductive toxicity, were risk factors for endometriosis but there lacks direct evidence on the possible role of PFASs in endometriosis-related infertility. To fill this gap, we examined the association between PFASs and endometriosis-related infertility among Chinese reproductive-age women in a case-control study, which comprised 157 surgically confirmed endometriosis cases and 178 controls seeking infertility treatment because of male reproductive dysfunction in 2014 and 2015...
March 7, 2017: Environment International
https://www.readbyqxmd.com/read/28282410/biomathematical-pattern-of-emg-signal-propagation-in-smooth-muscle-of-the-non-pregnant-porcine-uterus
#5
Malgorzata Domino, Bartosz Pawlinski, Zdzislaw Gajewski
Uterine contractions are generated by myometrial smooth muscle cells (SMCs) that comprise most of the myometrial layer of the uterine wall. Aberrant uterine motility (i.e., hypo- or hyper-contractility or asynchronous contractions) has been implicated in the pathogenesis of infertility due to the failure of implantation, endometriosis and abnormal estrous cycles. The mechanism whereby the non-pregnant uterus initiates spontaneous contractions remains poorly understood. The aim of the present study was to employ linear synchronization measures for analyzing the pattern of EMG signal propagation (direction and speed) in smooth muscles of the non-pregnant porcine uterus in vivo using telemetry recording system...
2017: PloS One
https://www.readbyqxmd.com/read/28277116/regulation-of-endometrial-cell-proliferation-by-estrogen-induced-bdnf-signaling-pathway
#6
Fangzheng Dong, Qiyao Zhang, Wei Kong, Jun Chen, Junlan Ma, Li Wang, Yanian Wang, Yan Liu, Yan Li, Ji Wen
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin growth factors family. Recent studies indicated that the level of BDNF in follicular fluid is a marker for oocyte quality and infertility. Here, we intend to further investigate the function of BDNF and its signaling pathway in the regulation of endometrial cells proliferation. We found that BDNF is a critical growth factor in endometrial cells. Activation of signal transducer and activator of transcription 3 signaling pathway is required for BNDF-regulated endometrial cell proliferation...
March 2, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28266237/frozen-embryo-transfer-cycles-in-women-with-deep-endometriosis
#7
George Queiroz Vaz, Alessandra Viviane Evangelista, Maria Cecilia Almeida Cardoso, Paulo Gallo, Maria Cecilia Erthal, Marco Aurelio Pinho Oliveira
OBJECTIVE: To compare the transfer pregnancy rates with frozen embryos from patients with deep endometriosis and non-endometriosis patients. METHODS: We conducted a retrospective cohort study of review of medical records of 181 women aged 18-40 years, undergoing transfer of frozen embryos into a fertility center. The data collected was from January 2007 to December 2013. RESULTS: Regarding the patients with endometriosis, there was no statistical difference in proportion to compare polycystic ovarian syndrome, male factor, tubal factor and unexplained infertility...
March 7, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28251627/clinicians-perceptions-of-women-s-experiences-of-endometriosis-and-of-psychosocial-care-for-endometriosis
#8
Kate Young, Jane Fisher, Maggie Kirkman
BACKGROUND: Endometriosis is a complex, chronic condition with known psychological and social implications for women. Little is known about clinicians' perceptions of the psychosocial aspects of endometriosis and associated care. AIM: To describe clinicians' perceptions of women's experiences of living with endometriosis and of the provision of psychosocial care for endometriosis. MATERIALS AND METHODS: A qualitative approach was taken using semi-structured interviews with eight gynaecologists and four general practitioners who provide care to women with endometriosis in Victoria, conducted by telephone and in person from June to December 2014...
February 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28238309/-deep-infiltrative-endometriosis-without-digestive-involvement-what-is-the-impact-of-surgery-on-in-vitro-fertilization-outcomes-a-retrospective-study
#9
L Mounsambote, J Cohen, S Bendifallah, E Mathieu d'Argent, L Selleret, N Chabbert-Buffet, M Ballester, J M Antoine, E Daraï
OBJECTIVES: To evaluate the impact of complete removal of endometriosis in case of deep infiltrative endometriosis without digestive involvement, on in vitro fertilization outcomes. METHODS: Retrospective monocentric study. We included infertile women with deep infiltrative endometriosis without colorectal involvement that underwent IVF. Women were divided in two groups, following their history: "surgery" when they underwent complete endometriosis resection before IVF and "without surgery" when they underwent IVF without endometriosis removal...
January 2017: Gynecol Obstet Fertil Senol
https://www.readbyqxmd.com/read/28218307/effects-of-u0126-and-mk2206-on-cell-growth-and-re-growth-of-endometriotic-stromal-cells-grown-on-substrates-of-varying-stiffness
#10
Sachiko Matsuzaki, Jean-Luc Pouly, Michel Canis
Endometriosis is a common gynecological disorder responsible for infertility and pelvic pain. A complete cure for patients with endometriosis awaits new targets and strategies. Here we show that U0126 (a MEK inhibitor) and MK2206 (an AKT inhibitor) synergistically inhibit cell growth of deep endometriotic stromal cells (DES) grown on polyacrylamide gel substrates (PGS) of varying stiffness (2 or 30 kilopascal [kPa]) or plastic in vitro. No significant differences in cell proliferation were observed among DES, endometrial stromal cells of patients with endometriosis (EES) from the proliferative phase (P), EES-S (secretory phase) and EES-M (menstrual phase) compared to cells grown on a substrate of the same stiffness at both higher (U0126 [30 μM] and MK2206 [9 μM]) and lower (U0126 [15 μM] and MK2206 [4...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28216457/endometriosis-in-hydatid-cysts-of-morgagni-a-retrospective-cohort-study-of-another-atypical-manifestation-of-endometriosis
#11
Shweta Gupta, Jeffrey A Gavard, Elena Kraus, Patrick Yeung
OBJECTIVE: To report on the presence and rate of endometriosis in hydatid cysts of Morgagni found at the time of excision surgery for endometriosis, and to describe any association of endometriosis in hydatid cysts of Morgagni to preoperative or operative factors. DESIGN: Retrospective cohort study DESIGN: Classification: Canadian Task Force Classification Level II-2 evidence SETTING: Center for Endometriosis at Saint Louis University, a tertiary referral center for endometriosis PATIENTS: Women who underwent optimal excision surgery for suspected endometriosis due to chronic pelvic pain and/or infertility and who also had hydatid cysts of Morgagni removed at the time of surgery, when found...
February 16, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28212593/micrornas-and-endometriosis-distinguishing-drivers-from-passengers-in-disease-pathogenesis
#12
Warren B Nothnick
Endometriosis is a disease common in women of reproductive age, characterized by pelvic pain and infertility. Despite its prevalence, the factors and mechanisms which contribute to the development and survival of ectopic lesions remain uncertain. MicroRNAs (miRNAs) are small RNA molecules that regulate posttranscriptional gene regulation which have been proposed to contribute to the pathogenesis of many diseases including that of endometriosis. This review summarizes the results of initial studies describing differentially expressed miRNAs between endometriotic lesion tissue and eutopic endometrium...
March 2017: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/28186620/an-update-on-the-diagnosis-surgical-management-and-fertility-outcomes-for-women-with-endometrioma
#13
REVIEW
Ryan Cranney, George Condous, Shannon Reid
Endometriosis is estimated to affect up to 50% of infertile women, and severity of endometriosis stage appears to correlate with reduced fertility. Ovarian endometriomas are found in up to 44% of women with endometriosis, and are significantly associated with the presence of pelvic deep infiltrating endometriosis, ovarian adhesions, and pouch of Douglas obliteration. Through the use of MEDLINE and PubMed databases, we conducted a literature review of all available research related to the diagnosis, surgical management and fertility outcomes for women with endometrioma...
February 10, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28174513/cervical-mucus-proteome-in-endometriosis
#14
Giuseppe Grande, Federica Vincenzoni, Domenico Milardi, Giuseppina Pompa, Domenico Ricciardi, Erika Fruscella, Francesca Mancini, Alfredo Pontecorvi, Massimo Castagnola, Riccardo Marana
BACKGROUND: Endometriosis is a chronic gynecological inflammatory disease characterized by the presence of functional endometrial glands and stroma outside of the uterine cavity. It affects 7-10% of women of reproductive age and up to 50% of women with infertility. The current gold standard for the diagnosis combines laparoscopic evaluation and biopsy of the visualized lesions. However, laparoscopy requires general anesthesia and developed surgical skills and it has a high procedural cost...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28173742/ultrastructural-evaluation-of-eutopic-endometrium-of-infertile-women-with-and-without-endometriosis-during-the-window-of-implantation
#15
Michele G Da Broi, Carlos V Rocha, Filomena M Carvalho, Wellington P Martins, Rui A Ferriani, Paula A Navarro
Endometriosis is frequently associated with infertility and it is believed that the impairment of endometrial receptivity may be one of the mechanisms involved in this condition. Pinopodes are endometrial cycle-dependent structures that seem to participate in embryo implantation, and alterations in their presence and/or morphology during the window of implantation could affect the endometrial receptivity and be involved in the disease-related infertility. However, the data on pinopodes in these women are scarce and inconclusive...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28160506/evaluation-of-the-effect-of-indomethacin-and-piroxicam-administration-before-embryo-transfer-on-pregnancy-rate
#16
Serkan Kumbasar, Özer Gül, Aytek Şık
AIM: The aim of this study was to evaluate the effect of non-steroidal anti-inflammatory drug (NSAID) administration before embryo transfer (ET) on pregnancy rates in women undergoing in vitro fertilization/intracytoplasmic sperm injection ET. METHODS: Our study included 255 patients diagnosed with primary or secondary infertility caused by a male or tubal-related factor, endometriosis or unexplained factors. The patients were divided randomly into three groups...
March 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28131909/differential-gene-expression-by-1-25-oh-2d3-in-an-endometriosis-stromal-cell-line
#17
Sue Ann Ingles, Liang Wu, Benjamin T Liu, Yibu Chen, Chun-Yeh Wang, Claire Templeman, Doerthe Brueggmann
Endometriosis is a common female reproductive disease characterized by invasion of endometrial cells into other organs, frequently causing pelvic pain and infertility. Alterations of the vitamin D system have been linked to endometriosis incidence and severity. To shed light on the potential mechanism for these associations, we examined the effects of 1,25(OH)2D3 on gene expression in endometriosis cells. Stromal cell lines derived from endometriosis tissue were treated with 1,25(OH)2D3, and RNA-seq was used to identify genes differentially expressed between treated and untreated cells...
January 28, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28120470/hepatitis-b-virus-infection-status-and-infertility-causes-in-couples-seeking-fertility-treatment-indicator-of-impaired-immune-response
#18
Terence T Lao, Jennifer S M Mak, Tin-Chiu Li
PROBLEM: The relationship between hepatitis B (HBV) infection in infertile couples seeking in vitro fertilization (IVF) treatment and infertility causes is unknown. METHODS OF STUDY: A total of 831 infertile couples attending our unit seeking IVF during January to December 2015 were recruited. RESULTS: HBV infection was found in 6.3% and 7.3% of female and male partners, respectively, and infection in one or both partners was associated with less primary infertility (44...
January 25, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28118836/the-impact-of-endometriosis-on-the-outcome-of-assisted-reproductive-technology
#19
Mireia González-Comadran, Juan Enrique Schwarze, Fernando Zegers-Hochschild, Maria do Carmo B Souza, Ramon Carreras, Miguel Ángel Checa
BACKGROUND: Endometriosis has been described to impair fertility through various mechanisms. However, studies evaluating the reproductive outcomes of women undergoing assisted reproductive technologies show controversial results. The aim of this study is to assess whether the reproductive outcome is impaired among women with endometriosis-associated infertility undergoing IVF. METHODS: A retrospective cohort study was performed, including women undergoing IVF reported by the Red Latinoamericana de Reproduccion Asistida (Redlara) registry, between January 2010 and December 2012...
January 24, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28114727/nonsteroidal-anti-inflammatory-drugs-for-pain-in-women-with-endometriosis
#20
REVIEW
Julie Brown, Tineke J Crawford, Claire Allen, Sally Hopewell, Andrew Prentice
BACKGROUND: Endometriosis is a common gynaecological condition that affects women and can lead to painful symptoms and infertility. It greatly affects women's quality of life, impacting their careers, everyday activities, sexual and nonsexual relationships and fertility. Nonsteroidal anti-inflammatory drugs (NSAIDs) are most commonly used as first-line treatment for women with pain associated with endometriosis. OBJECTIVES: To assess effects of NSAIDs used for management of pain in women with endometriosis compared with placebo, other NSAIDs, other pain management drugs or no treatment...
January 23, 2017: Cochrane Database of Systematic Reviews
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