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endometriosis & infertility

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https://www.readbyqxmd.com/read/29786828/oral-contraceptives-for-pain-associated-with-endometriosis
#1
REVIEW
Julie Brown, Tineke J Crawford, Shree Datta, Andrew Prentice
BACKGROUND: Endometriosis is a common gynaecological condition which affects many women of reproductive age worldwide and is a major cause of pain and infertility. The combined oral contraceptive pill (COCP) is widely used to treat pain occurring as a result of endometriosis, although the evidence for its efficacy is limited. OBJECTIVES: To determine the effectiveness, safety and cost-effectiveness of oral contraceptive preparations in the treatment of painful symptoms ascribed to the diagnosis of laparoscopically proven endometriosis...
May 22, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29783992/a-review-of-the-risk-factors-genetics-and-treatment-of-endometriosis-in-chinese-women-a-comparative-update
#2
REVIEW
Yi Dai, Xiaoyan Li, Jinghua Shi, Jinhua Leng
Endometriosis is one of the major causes of economic burden and compromised quality of life in a very large percentage of Asian women. While it is perceived as a benign condition, recent research has shown that it may be a significant cause of infertility and metastatic cancer. It has also been associated with other diseases linked to the functioning of the immune system. Genetic as well as environmental factors are known to affect the manifestation and progression of endometriosis. This review aims to summarize recent research pertaining to the risk factors, diagnosis and treatment of endometriosis in Chinese women...
May 21, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29779580/animal-models-of-endometriosis-replicating-the-aetiology-and-symptoms-of-the-human-disorder
#3
REVIEW
Ioannis Simitsidellis, Douglas A Gibson, Philippa T K Saunders
Endometriosis is a chronic incurable disorder that affects 1 in 10 women of reproductive age: associated symptoms include chronic pain and infertility. The aetiology of endometriosis remains poorly understood but patients, clinicians and researchers are all in agreement that new non-surgical therapies are urgently needed to reduce the severity of symptoms. Preclinical testing of drugs requires the development and validation of models that recapitulate the key features of the disorder. In this review we describe the best-validated animal models (primate, rodent, xenograft) and their contributions to our understanding of the factors underpinning the development of symptoms...
June 2018: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29771400/inflammatory-cytokines-il-6-il-10-il-13-tnf-%C3%AE-and-peritoneal-fluid-flora-were-associated-with-infertility-in-patients-with-endometriosis
#4
X-M Wang, Z-Y Ma, N Song
OBJECTIVE: To investigate the correlations of inflammatory factors, interleukin-6 (IL-6), IL-10, IL-13 and tumor necrosis factor-α (TNF-α), and composition of bacterial flora in the peritoneal fluid with infertility in endometriosis patients. PATIENTS AND METHODS: A total of 55 patients diagnosed with endometriosis and infertility in the Gynecology Clinic of our hospital from June 2014 to July 2017 were selected as observation group, and another 30 non-endometriosis and non-infertility patients were enrolled as control group...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29769513/ovarian-endometrioid-adenocarcinoma-arising-in-endometriosis-a-case-report
#5
K Nahar, B Ferdous, N Akhter, P A Shamsunnahar, K Khatun, S A Begum, M A Aziz
Malignant transformation of ovarian endometriosis was first described in 1925 by Sampson; later on it has been described in extragonadal regions by few authors also. Ovarian endometrioid and clear cell carcinoma are highly associated with endometriosis. Here we present a case of malignant transformation of ovarian endometrioma into endometrioid adenocarcinoma and review the clinical and pathological features of these tumors. A 45-years old infertile woman diagnosed as a case of bilateral chocolate cyst with pelvic endometriosis underwent total hysterectomy with bilateral salpingo-oophorectomy...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29763921/peptidomic-analysis-of-endometrial-tissue-from-patients-with-ovarian-endometriosis
#6
Yunping Xue, Pengfei Xu, Sujuan Xu, Kai Xue, Lingling Xu, Jie Chen, Juan Xu, Xiaoyan Shi, Qian Li, Lin Gu
BACKGROUND/AIMS: Ovarian endometriosis (OvE) is ovarian cyst that is lined with endometrial tissue. They are found in 17-44% of women with endometriosis. Their clinical manifestations include pelvic pain, dysmenorrhea, dyspareunia, and infertility. Although the incidence of OvE has increased yearly, the exact pathogenesis of OvE is still unclear. We used peptidomics, an emerging branch of proteomics, to identify differentially expressed peptides in order to determine the possible roles of these peptides in the pathogenesis of OvE...
May 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29762665/mir-194-3p-represses-the-progesterone-receptor-and-decidualization-in-eutopic-endometrium-from-women-with-endometriosis
#7
Tianjiao Pei, Chang Liu, Tingting Liu, Li Xiao, Bin Luo, Jing Tan, Xueying Li, Guojun Zhou, Changling Duan, Wei Huang
Progesterone resistance in the eutopic endometrium (EuE) is suggested to be a critical factor for decreased endometrial receptivity and implantation failure in reproductive-aged women with endometriosis. Altered expression of miRNAs has been reported to play an important role in the pathophysiology of endometriosis-associated infertility. However, the underlying mechanisms of aberrant progesterone receptor (PR) and deficient decidualization regulated by miRNAs in endometriosis have not been thoroughly elucidated...
May 11, 2018: Endocrinology
https://www.readbyqxmd.com/read/29755032/effects-of-mature-cystic-teratoma-on-reproductive-health-and-malignant-transformation-a-retrospective-analysis-of-80-cases
#8
Sefa Kurt, Hüseyin Aytuğ Avşar, Ömer Erbil Doğan, Hasan Bahadır Saatli, Uğur Saygılı
OBJECTIVE: Examining the cases of mature cystic teratoma (MCT) that are diagnosed and treated in our clinic regarding their association with fertility; and detecting the rate of malignant degeneration and the types of malignancies. MATERIAL AND METHODS: Patients, operated due to adnexal mass between April 2012 and August 2017 and diagnosed with MCT, were retrospectively examined. Mean age of the 80 cases, which met the criteria, was 30.60±10.5. 9 were suffering from infertility, according to hospital records...
May 14, 2018: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29755027/endometriosis-a-concise-practical-guide-to-current-diagnosis-and-treatment
#9
İbrahim Alkatout, Ivo Meinhold-Heerlein, Jörg Keckstein, Liselotte Mettler
This book addresses the management of endometriosis from a holistic approach, including theoretical principles, conservative treatment of the condition, diagnostic and surgical procedures, as well as the outcome of research. Endometriosis and its treatment are complex issues. We believe that a combination of treatment modalities is needed in order to effectively address the pain, infertility and other difficulties associated with endometriosis. In addition to theory and scientific principles, minimally invasive surgical procedures for the treatment of endometriosis are described in a stepwise manner...
May 14, 2018: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29743986/the-role-of-oxidative-stress-and-membrane-transport-systems-during-endometriosis-a-fresh-look-at-a-busy-corner
#10
REVIEW
Salvatore Giovanni Vitale, Stella Capriglione, Isabel Peterlunger, Valentina Lucia La Rosa, Amerigo Vitagliano, Marco Noventa, Gaetano Valenti, Fabrizio Sapia, Roberto Angioli, Salvatore Lopez, Giuseppe Sarpietro, Diego Rossetti, Gabriella Zito
Endometriosis is a condition characterized by the presence of endometrial tissue outside the uterine cavity, leading to a chronic inflammatory reaction. It is one of the most widespread gynecological diseases with a 10-15% prevalence in the general female population, rising up to 30-45% in patients with infertility. Although it was first described in 1860, its etiology and pathogenesis are still unclear. It is now accepted that inflammation plays a central role in the development and progression of endometriosis...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29741687/bowel-surgery-as-a-fertility-enhancing-procedure-in-patients-with-colorectal-endometriosis-methodological-pathogenic-and-ethical-issues
#11
Paolo Vercellini, Paola Viganò, Maria Pina Frattaruolo, Alessandra Borghi, Edgardo Somigliana
Bowel surgery for colorectal endometriosis is being promoted to infertile women without severe sub-occlusive symptoms, with the objective of improving the likelihood of conception. Contrary to rectal shaving, bowel surgery involving full-thickness disk excision and segmental resection entails opening of the intestinal lumen thus increasing the risk of postoperative infectious complications. About 1 in 10 patients undergoing colorectal resection for intestinal endometriosis will experience severe sequelae, including anastomotic dehiscence, rectovaginal fistula formation, and bladder and bowel denervation...
May 7, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29737300/effect-of-laparoscopy-combined-with-mifepristone-in-the-treatment-of-endometriosis-and-drug-reaction-analysis
#12
Jing Li, Huilin Yang, Jie Song
Endometriosis is a common benign disease of Gynecology, which often causes symptoms of dysmenorrhea, pelvic pain and infertility. In this paper, we analyzed the effect of laparoscopy combined with mifepristone in the treatment of endometriosis. By observing the clinical efficacy and side effects of small dose mifepristone, we explored the feasibility of small dose mifepristone in the treatment of recurrent endometriosis. The results showed that the clinical symptoms of small dose mifepristone group and danazol group were improved to varying degrees...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29736151/transcription-regulatory-factor-expression-in-t-helper-cell-differentiation-pathway-in-eutopic-endometrial-tissue-samples-of-women-with-endometriosis-associated-with-infertility
#13
Halyna D Koval, Valentyna V Chopyak, Oleksandr M Kamyshnyi, Maciej K Kurpisz
Endometriosis is a disease of epidemiological gravity of unknown primary reason. A complex of constitutional factors including the immune system has been considered as its background. The aim of the study was to identify Th1 and Th2 cells as well as the T-regulatory subset in the endometrium of women with endometriosis associated with infertility upon transcription factors expression. Expression of T-bet, GATA3, and Foxp3 genes was examined using a method of polymerase chain reaction (PCR) in the eutopic endometrial samples of 20 women with endometriosis associated with infertility and 20 women with infertility of tubal origin...
2018: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29735467/effect-of-laparoscopy-combined-with-mifepristone-in-the-treatment-of-endometriosis-and-drug-reaction-analysis
#14
Jing Li, Huilin Yang, Jie Song
Endometriosis is a common benign disease of Gynecology, which often causes symptoms of dysmenorrhea, pelvic pain and infertility. In this paper, we analyzed the effect of laparoscopy combined with mifepristone in the treatment of endometriosis. By observing the clinical efficacy and side effects of small dose mifepristone, we explored the feasibility of small dose mifepristone in the treatment of recurrent endometriosis. The results showed that the clinical symptoms of small dose mifepristone group and danazol group were improved to varying degrees...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29712562/endometrium-metabolomic-profiling-reveals-potential-biomarkers-for-diagnosis-of-endometriosis-at-minimal-mild-stages
#15
Jingjie Li, Lihuan Guan, Huizhen Zhang, Yue Gao, Jiahong Sun, Xiao Gong, Dongshun Li, Pan Chen, Xiaoyan Liang, Min Huang, Huichang Bi
BACKGROUND: The sensitivity and specificity of non-invasive diagnostic methods for endometriosis, especially at early stages, are not optimal. The clinical diagnostic indicator cancer antigen 125 (CA125) performs poorly in the diagnosis of minimal endometriosis, with a sensitivity of 24%. Therefore, it is urgent to explore novel diagnostic biomarkers. We evaluated the metabolomic profile variation of the eutopic endometrium between minimal-mild endometriosis patients and healthy women by ultra-high-performance liquid chromatography coupled with electrospray ionization high-resolution mass spectrometry (UHPLC-ESI-HRMS)...
April 30, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29709485/endometriosis-surgery-and-preservation-of-fertility-what-surgeons-should-know
#16
H Roman
Colorectal surgeons often participate in the multidisciplinary management of young females with endometriosis. Complications of endometriosis as well as its management often result in infertility since they can involve all pelvic organs including the procreative organs: uterus, ovaries and fallopian tubes. Complete excision of all endometriotic lesions should not be performed at the expense of irreversible destruction of the procreative organs; definitive infertility should not be the price to pay in order to obtain an improvement of the painful symptoms caused by endometriosis...
April 27, 2018: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29703252/investigation-of-the-slc22a23-gene-in-laryngeal-squamous-cell-carcinoma
#17
Seda Ekizoglu, Didem Seven, Turgut Ulutin, Jalal Guliyev, Nur Buyru
BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) is the second most common cancer of the head and neck. In order to identify differentially expressed genes which may have a role in LSCC carcinogenesis, we performed GeneFishing Assay. One of the differentially expressed genes was the SLC22A23 (solute carrier family 22, member 23) gene. SLC22A23 belongs to a family of organic ion transporters that are responsible for the absorption or excretion of many drugs, xenobiotics and endogenous compounds in a variety of tissues...
April 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29701376/what-about-having-a-hydropneumothorax-every-month
#18
Sara Lopes, João Maciel, Pedro Cabral Bastos, Paulo Pinho
INTRODUCTION: Endometriosis is a pathological, benign, inflammatory condition characterized by the presence of endometrial glands and stroma outside the uterine cavity, typically in the pelvis. In rare conditions, this estrogen-dependent disease may be extrapelvic, presenting with a variety of symptoms, including Thoracic Endometriosis. METHODS: A 37 year-old woman presented with her third right hydropneumothorax in three months. Her medical history included infertility, an ovarian mass (in study), biliary diskinesia and protein C deficiency...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29694619/functional-magnetic-resonance-imaging-for-clinical-evaluation-of-uterine-contractility
#19
Vinicius Adami Vayego Fornazari, Stela Adami Vayego, Denis Szejnfeld, Jacob Szejnfeld, Suzan Menasce Goldman
Uterine contractility out of the gestational phase, during the menstrual cycle and the habitual functional variations of the organ, this is one of the responsible mechanisms for reproduction and fertility, due to its direct action in the mechanisms conducting the spermatozoa to the ovule and in the decidual implantation. Pathologies such as uterine leiomyoma, endometriosis, adenomyosis, polycystic ovarian syndrome, as well as the use of intrauterine devices and oral contraceptives, may alter a functionality of uterine contractility...
2018: Einstein
https://www.readbyqxmd.com/read/29681721/progesterone-hypersensitivity-a-challenge-for-luteal-support
#20
Astha Gupta, Deepak Goenka, Mohan L Goenka
Progesterone hypersensitivity is a rare phenomenon which can occur after both endogenous and exogenous exposures. We present a case of hypersensitivity to various forms and routes of exogenous progesterone. A 27-year-old female presented with primary infertility. Investigations revealed Grade 1 endometriosis and polycystic ovary syndrome. Three cycles of intrauterine insemination were attempted which were unsuccessful and in vitro fertilization was proceeded. Six blastocysts of Grade A were formed and cryopreserved...
January 2018: Journal of Human Reproductive Sciences
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