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endometriosis & infertility

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https://www.readbyqxmd.com/read/28089574/does-preoperative-antim%C3%A3-llerian-hormone-level-influence-postoperative-pregnancy-rate-in-women-undergoing-surgery-for-severe-endometriosis
#1
Emanuela Stochino-Loi, Basma Darwish, Oana Mircea, Salma Touleimat, Jenny-Claude Millochau, Carole Abo, Stefano Angioni, Horace Roman
OBJECTIVE: To compare postoperative pregnancy rates as they relate to presurgery antimüllerian hormone (AMH) level in patients with stage 3 and 4 endometriosis. DESIGN: Retrospective comparative study using data prospectively recorded in the North-West Inter-Regional Female Cohort for Patients with Endometriosis (CIRENDO) database. SETTING: University tertiary referral center. PATIENT(S): One hundred eighty patients with stage 3 and 4 endometriosis and pregnancy intention, managed from June 2010 to March 2015, were divided into two groups according to their preoperative AMH levels: group A (AMH ≥2 ng/mL) and group B (AMH <2 ng/mL)...
January 12, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28074436/intrafollicular-inflammatory-cytokines-but-not-steroid-hormone-concentrations-are-increased-in-naturally-matured-follicles-of-women-with-proven-endometriosis
#2
Gengxiang Wu, N A Bersinger, M D Mueller, M von Wolff
PURPOSE: The aim of this study was to assess whether the intrafollicular cytokine profile in naturally developed follicles is different in women with endometriosis, possibly explaining the lower reproductive outcome in endometriosis patients. METHODS: A matched case-control study was conducted at a university-based infertility and endometriosis centre. The study population included 17 patients with laparoscopically and histologically confirmed endometriosis (rAFS stages II-IV), each undergoing one natural cycle IVF (NC-IVF) treatment cycle between 2013 and 2015, and 17 age-matched NC-IVF women without diagnosed endometriosis (control group)...
January 10, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28063264/preimplantation-3d-ultrasound-current-uses-and-challenges
#3
Sushila Arya, Sanja Kupesic Plavsic
The preimplantation ultrasound (US) refers to targeted imaging of the uterus and adnexa prior to assisted reproductive techniques (ART) to optimize the infertility treatment outcomes. After a thorough evidence based literature review, we propose the use of transvaginal three-dimensional (3D) US during the early follicular phase. A systematic approach for 3D US examination consists of a detailed examination of the uterine shape, size and contour, evaluation of the endometrial thickness, volume, pattern and vascularity, and assessment of the junctional zone regularity, echogenicity and thickness...
January 7, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28049501/the-abnormal-expression-of-oxytocin-receptors-in-the-uterine-junctional-zone-in-women-with-endometriosis
#4
Miaomaio Huang, Xuqing Li, Peipei Guo, Zhaojuan Yu, Yuting Xu, Zhaolian Wei
BACKGROUND: The junctional zone (JZ), also called as the endometrial-myometrial junction, is related to peristaltic-like movements in the non-pregnant uterus. Hyperperistalsis and dysperistalsis of uterus constructions might underlie many important disorders such as dysmenorrhea, infertility, endometriosis, implantation failure. The major proteins for uterine contraction of the non-pregnant uterus may be Oxytocin (OT) and oxytocin receptor (OTR). The objective of this study was to inspect the expression of OTR in isthmic and mid-fundal parts of the uterine junctional zone at different stages of the follicular cycle in patients with and without endometriosis...
January 3, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28049216/cancer-implications-for-patients-with-endometriosis
#5
Mary Ann Wilbur, Ie-Ming Shih, James H Segars, Amanda N Fader
Endometriosis is defined as the presence of viable endometrial glands and stroma outside of the uterus. It is a common disease, occurring in 5 to 15% of all women. Endometriosis is associated with chronic pelvic pain and infertility and often requires surgical intervention for definitive treatment. Although it is a benign gynecologic condition, endometriosis shares pathophysiologic features with cancer. In recent years, both histologic and epidemiologic evidence has accumulated, suggesting that ovarian endometriosis may give rise to malignant ovarian tumors, primarily those that are epithelial in origin, known as endometriosis-associated ovarian carcinoma (EAOC) including ovarian clear cell carcinoma, endometrioid carcinoma, and the least common, seromucinous tumors...
January 3, 2017: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/28030942/the-role-of-vitamin-d-in-reproductive-dysfunction-in-women-a-systematic-review
#6
REVIEW
Patrycja Skowrońska, Ewa Pastuszek, Waldemar Kuczyński, Mariusz Jaszczoł, Paweł Kuć, Grzegorz Jakiel, Izabela Wocławek-Potocka, Krzysztof Łukaszuk
Vitamin D is essential for the proper functioning of the human body. There is also evidence of its strong association with fertility problems in women. This review aims to evaluate the relationship between vitamin D and diseases affecting women's fertility (polycystic ovarian syndrome (PCOS), uterine leiomyomas and endometriosis), and in vitro fertilization (IVF) outcome. A systematic review of the literature was conducted in Scopus and PubMed for relevant English language publications since 1989. Vitamin D influences the functioning of the reproductive system in women and has been associated with PCOS, uterine leiomyomas, endometriosis and in vitro fertilization (IVF) outcome...
23, 2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28030938/matrix-metalloproteinase-2-mmp-2-mmp-9-tissue-inhibitor-of-matrix-metalloproteinases-timp-1-and-transforming-growth-factor-%C3%AE-2-tgf-%C3%AE-2-expression-in-eutopic-endometrium-of-women-with-peritoneal-endometriosis
#7
Krzysztof Szymanowski, Mateusz Mikołajczyk, Przemysław Wirstlein, Anna Dera-Szymanowska
INTRODUCTION: The prevalence of endometriosis among reproductive age women is 7-17%; however, these figures reach 20-50% in patients suffering from infertility. Matrix metalloproteinases (MMPs) activity is thought to be particularly essential in the early phases of endometriosis development. Any changes in the equilibrium between MMPs activity and their tissue inhibitors (TIMPs) could be potentially harmful, promoting endometriosis development. The aim of this study was to investigate whether the MMP-2, MMP-9, TIMP-1 or TGF-B2 expression in eutopic endometrium from women with early endometriosis differ when compared with healthy subjects...
23, 2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28013318/tubal-telocytes-factor-infertility-reason
#8
Veronika Aleksandrovych, Marek Sajewicz, Jerzy A Walocha, Krzysztof Gil
Infertility is actually widespread pathological condition, which affected one in every four couples in developing countries. Approximately one third of all cases are connected with tubal factor infertility, o en accompanies by endometriosis, acute salpingitis, urogenital infections etc. The newly identified telocytes (TCs) have multiple potential bio-functions and might participate in the fertility problems. They influence on structural and functional integrity of oviduct tissue. Despite recent discovery, TCs involvement in the majority of physiological and pathological processes is still unclear and require significant increasing of deep observations and data analysis...
2016: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/28005934/obstetrical-complications-in-women-with-endometriosis-a-cohort-study-in-japan
#9
Takashi Harada, Fuminori Taniguchi, Kazunari Onishi, Youichi Kurozawa, Kunihiko Hayashi, Tasuku Harada
BACKGROUND: Endometriosis, which occurs in approximately 10% of women of reproductive age, is defined as the presence of endometrial tissue outside the uterus. Women with endometriosis are more likely to have difficulty conceiving and tend to receive infertility treatment, including assisted reproductive technology (ART) therapy. There has not yet been a prospective cohort study examining the effects of endometriosis on pregnancy outcome in pregnant Japanese women. METHODOLOGY: This was a prospective cohort study of the incidence of obstetrical complications in women with endometriosis using data of the Japan Environment & Children's Study (JECS)...
2016: PloS One
https://www.readbyqxmd.com/read/28004192/the-association-between-interleukin-10-il-10-592c-a-819t-c-1082g-a-promoter-polymorphisms-and-endometriosis
#10
Andrei Mihai Malutan, Cristina Drugan, Katharina Walch, Tudor Drugan, Razvan Ciortea, Dan Mihu
PURPOSE: Endometriosis has an incidence reaching up to 50% in infertile women. Cytokine-mediated immune responses seem to play an important role in endometriosis pathogenesis, but still the etiology and pathophysiology remain unclear. In the current study we tried to investigate whether there is a relationship between IL-10 genetic polymorphism, serum levels of IL-10 and the presence of advanced endometriosis. METHODS: The presence of IL-10 592C/A, 819T/C, 1082G/A promoter polymorphisms and IL-10 serum levels were investigated in advanced endometriosis patients compared to healthy controls...
December 21, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28003801/deep-infiltrating-endometriosis-affecting-the-urinary-tract-surgical-treatment-and-fertility-outcomes-in-2004-2013
#11
Liisu Saavalainen, Oskari Heikinheimo, Aila Tiitinen, Päivi Härkki
Urinary tract endometriosis (UTE) is a rare form of deep infiltrating endometriosis. We studied the operative treatment of UTE and evaluated postoperative recurrences and fertility outcomes. This is a retrospective cohort study of 53 women who underwent operative treatment for UTE in 2004-2013 at Helsinki University Hospital, and were followed-up until the end of 2014. The data were gathered from the hospital's electronic database. The main outcome measures were complications, reoperations, postoperative pregnancies, and deliveries...
2016: Gynecological Surgery
https://www.readbyqxmd.com/read/28002850/medical-management-of-endometriosis-in-patients-with-chronic-pelvic-pain
#12
Mohamed A Bedaiwy, Catherine Allaire, Paul Yong, Sukinah Alfaraj
Endometriosis is a common cause of pelvic pain in women of reproductive age. Traditional medical therapies are hormonal in nature, including estrogen-progestin contraceptives, progestins, and gonadotropin-releasing hormone (GnRH) agonists. Other hormonal options are androgens and aromatase inhibitors, with research also suggesting a possible role for GnRH antagonists and selective progesterone receptor modulators. Other than nonsteroidal anti-inflammatories, further work is required for nonhormonal therapies such as antiangiogenic and immune-modulating drugs...
December 21, 2016: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/27998009/endometriosis-associated-infertility-aspects-of-pathophysiological-mechanisms-and-treatment-options
#13
Tom Tanbo, Peter Fedorcsak
Endometriosis is a common condition in women of reproductive age. In addition to pain, endometriosis may also reduce fertility. The causes of infertility in women with endometriosis may range from anatomical distortions due to adhesions and fibrosis to endocrine abnormalities and immunological disturbances. In some cases, the various pathophysiological derangements seem to interact by mechanisms so far not fully understood. Whether surgery should be offered as a treatment option in endometriosis-associated infertility has become controversial, partly due to its modest or undocumented effect...
December 20, 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27979878/implications-of-telomeres-and-telomerase-in-endometrial-pathology
#14
REVIEW
D K Hapangama, A Kamal, G Saretzki
BACKGROUND: Eukaryotic chromosomal ends are linear and are protected by nucleoprotein complexes known as telomeres. The complex structural anatomy and the diverse functions of telomeres as well as the unique reverse transcriptase enzyme, telomerase that maintains telomeres are under intensive scientific scrutiny. Both are involved in many human diseases including cancer, but also in ageing and chronic disease such as diabetes. Their intricate involvement in many cellular processes and pathways is being dynamically deciphered in many organs including the endometrium...
December 15, 2016: Human Reproduction Update
https://www.readbyqxmd.com/read/27965399/selenium-binding-protein-1-autoantibodies-in-ovarian-disorders-and-ovarian-cancer
#15
Yi Yu-Rice, Seby L Edassery, Nicole Urban, Ingegerd Hellstrom, Karl Eric Hellstrom, Youping Deng, Yan Li, Judith Luborsky
Infertility is a risk factor for ovarian cancer (OvCa). The goal was to determine if antibodies to Selenium Binding Protein 1 (SBP1), an autoantibody we identified in patients with premature ovarian failure (POF), occurs in both infertility and OvCa patients, and thus could be associated with preneoplasia. Anti-SBP1 was measured by immunoassay against recombinant SBP1, in sera from OvCa (n=41), infertility (n=92) and control (n=87) patients. Infertility causes were POF, unexplained, irregular ovulation or endometriosis...
December 13, 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27951613/strategies-for-management-of-colorectal-endometriosis
#16
Mauricio Simões Abrão, Giuliano Moysés Borrelli, Roberto Clarizia, Rosanne Marie Kho, Marcello Ceccaroni
Endometriosis has clearly three distinct clinical presentations and deep endometriosis, especially compromising the rectosigmoid is probably the most concerning one for both patients and surgeons. Currently, with the available tools, it is mandatory to have a precise diagnostic of this type of disease prior to indication of treatment. Strategies to manage this form of endometriosis will take into account several involved aspects, such as age of the patient, reproductive desire or infertility, clinical symptoms, as well as the extension and localization of the disease...
December 12, 2016: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/27932897/effect-of-ovarian-endometrioma-on-uterine-and-ovarian-blood-flow-in-infertile-women
#17
Akmal El-Mazny, Ahmed Kamel, Wafaa Ramadan, Sherine Gad-Allah, Suzy Abdelaziz, Ahmed M Hussein
BACKGROUND: Angiogenesis has been found to be among the most important factors in the pathogenesis of endometriosis. The formation of new blood vessels is critical for the survival of newly implanted endometriotic foci. The use of 3-D power Doppler allows for the demonstration of the dynamic vascular changes that occur during the process of in vitro fertilization (IVF). We aimed to evaluate the effect of ovarian endometrioma on uterine and ovarian blood flow in infertile women. MATERIALS AND METHODS: In a case-control study at a university teaching hospital, 138 women with unilateral ovarian endometrioma scheduled for IVF were compared to 138 women with male-factor or unexplained infertility...
2016: International Journal of Women's Health
https://www.readbyqxmd.com/read/27932523/treatment-of-recurrent-ovarian-cysts-and-primary-infertility-by-iranian-traditional-medicine-a-case-report
#18
Mehdi Salehi, Mohammad Setayesh, Roshanak Mokaberinejad
Infertility is a medical and psychosocial problem with a high prevalence. There are different treatments for this problem in Iranian traditional medicine. A 28-year-old woman presented with the complaints of 4 emergency operations of the left ovarian cyst during 4 years and infertility. Diagnostic laparoscopy showed an ovarian cyst, adhesion, and endometriosis. Hysteroscopy was unremarkable. After 2 months of letrozole administration, the ovarian cyst ruptured again. Considering the failure of conventional treatments, Iranian traditional medicine products were administered to the patient...
December 8, 2016: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/27926972/management-of-endometriosis-in-the-infertile-patient
#19
Edgardo Somigliana, Paola Vigano, Laura Benaglia, Andrea Busnelli, Nicola Berlanda, Paolo Vercellini
The management of endometriosis-related infertility remains debated. However, in recent years, the role of in vitro fertilization (IVF) has progressively grown. Reasons to explain this change include (1) the improvement of the effectiveness and safety of IVF, (2) the raised awareness of the modest effectiveness of surgery, (3) the inherent risks of surgery including in particular the damage to the ovarian reserve when ovarian endometriomas have to be removed, (4) the ineffectiveness of intrauterine insemination and the possible risks of endometriosis progression associated with the use of this technique...
December 7, 2016: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/27926971/management-of-endometriomas
#20
Ludovico Muzii, Chiara Di Tucci, Mara Di Feliciantonio, Giulia Galati, Ludovica Verrelli, Violante Di Donato, Claudia Marchetti, Pierluigi Benedetti Panici
Ovarian endometriomas affect 17 to 44% of women with endometriosis, and are often associated with pelvic pain and infertility. Treatment options include expectant management, medical and/or surgical treatment, and in vitro fertilization and embryo transfer (IVF-ET). The choice of treatment depends mostly on the associated symptoms. In most cases, surgery is the preferred choice, since endometriomas do not respond to medical treatment, which may only treat associated pain. In case of infertility, IVF-ET may be a suitable alternative to surgery, particularly when there is no associated pain...
December 7, 2016: Seminars in Reproductive Medicine
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