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https://www.readbyqxmd.com/read/29452837/dramatically-polarized-opinion-on-the-role-of-brachytherapy-boost-in-management-of-high-risk-prostate-cancer-a-survey-of-north-american-genitourinary-expert-radiation-oncologists
#1
Shearwood McClelland, Kiri A Sandler, Catherine Degnin, Yiyi Chen, Timur Mitin
INTRODUCTION: Three randomized clinical trials have established brachytherapy (BT) boost in combination with external beam radiation therapy (EBRT) and androgen deprivation therapy (ADT) as superior to definitive EBRT and ADT alone in terms of biochemical control (but not overall survival) at the expense of increased toxicity in men with high-risk (HR) prostate cancer (PCa). The current view regarding these 2 treatment algorithms among North American genitourinary (GU) experts is not known...
February 2, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29447724/no-127-the-evaluation-of-stress-incontinence-prior-to-primary-surgery
#2
Scott A Farrell
OBJECTIVE: To provide clinical guidelines for the evaluation of women with stress urinary incontinence prior to primary anti-incontinence surgery. OPTIONS: The modalities of evaluation range from basic pelvic examination through to the use of adjuncts including ultrasound and urodynamic testing. OUTCOMES: These guidelines provide a comprehensive approach to the preoperative evaluation of urinary incontinence to ensure that excessive evaluation is avoided without sacrificing diagnostic accuracy...
February 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29444208/death-on-demand-an-analysis-of-physician-administered-euthanasia-in-the-netherlands
#3
Robert Preston
Background: Physician-administered euthanasia (PAE) was legalized, along with physician-assisted suicide (PAS), in The Netherlands in 2001. Sources of data: Annual reports of the Dutch Regional Euthanasia Review Committees, the committees' 2015 published Code of Practice and research studies. Areas of agreement: There is a general openness about the practice of PAE/PAS in The Netherlands and an avoidance of misleading euphemisms. The 2001 law also includes arrangements for post-event review of PAE/PAS decisions...
February 12, 2018: British Medical Bulletin
https://www.readbyqxmd.com/read/29441607/an-international-urogynecological-association-iuga-international-continence-society-ics-joint-report-on-the-terminology-for-the-assessment-of-sexual-health-of-women-with-pelvic-floor-dysfunction
#4
Rebecca G Rogers, Rachel N Pauls, Ranee Thakar, Melanie Morin, Annette Kuhn, Eckhard Petri, Brigitte Fatton, Kristene Whitmore, Sheryl Kinsberg, Joseph Lee
AIMS: The terminology in current use for sexual function and dysfunction in women with pelvic floor disorders lacks uniformity, which leads to uncertainty, confusion, and unintended ambiguity. The terminology for the sexual health of women with pelvic floor dysfunction needs to be collated in a clinically-based consensus report. METHODS: This report combines the input of members of the Standardization and Terminology Committees of two International Organizations, the International Urogynecological Association (IUGA), and the International Continence Society (ICS), assisted at intervals by many external referees...
February 14, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29441511/-cardiology-telemedicine-solutions-opinion-of-the-committee-of-informatics-and-telemedicine-of-polish-society-of-cardiology-section-of-non-invasive-electrocardiology-and-telemedicine-of-polish-society-of-cardiology-and-clinical-sciences-committee-of-the
#5
Ryszard Piotrowicz, Paweł Krzesiński, Paweł Balsam, Maciej Kempa, Renata Główczyńska, Marcin Grabowski, Łukasz Kołtowski, Ewa Lewicka, Michał Peller, Ewa Piotrowicz, Jakub Podolec, Adam Stańczyk, Justyna Zajdel, Grzegorz Opolski
For several years, we have observed the dynamic development of technologies that allow patients to access medical care from the comfort of their homes, without direct contact with the doctor. Innovative solutions based on telemedicine improve care coordination and communication among clinicians, patients, and their families, as well as increases patients' security and gives them greater independence, thus eliminating health care inequalities. The rapidly growth of telemedicine and the adoption of new technologies in clinical practice is also observed in Poland...
February 14, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29439085/idea-intervention-to-prevent-depressive-symptoms-and-promote-well-being-in-early-stage-dementia-protocol-for-a-randomised-controlled-feasibility-study
#6
Remco Tuijt, Gill Livingston, Rebecca L Gould, Rebecca Jones, Elisabet Sole Verdaguer, Vasiliki Orgeta
OBJECTIVE: Depressive symptoms are common among people with dementia, impacting quality of life and cognitive and functional decline. Currently, little is known about the acceptability and feasibility of psychological interventions for people with mild dementia, with recent reviews identifying the need for further evidence. Developing and evaluating psychological interventions to prevent and treat these symptoms is, therefore, an important clinical and research priority. This protocol describes a study testing the acceptability and feasibility of a manual-based behavioural activation (BA) intervention for preventing and treating depressive symptoms in people with mild dementia...
February 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29435801/cosmin-guideline-for-systematic-reviews-of-patient-reported-outcome-measures
#7
C A C Prinsen, L B Mokkink, L M Bouter, J Alonso, D L Patrick, H C W de Vet, C B Terwee
PURPOSE: Systematic reviews of patient-reported outcome measures (PROMs) differ from reviews of interventions and diagnostic test accuracy studies and are complex. In fact, conducting a review of one or more PROMs comprises of multiple reviews (i.e., one review for each measurement property of each PROM). In the absence of guidance specifically designed for reviews on measurement properties, our aim was to develop a guideline for conducting systematic reviews of PROMs. METHODS: Based on literature reviews and expert opinions, and in concordance with existing guidelines, the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) steering committee developed a guideline for systematic reviews of PROMs...
February 12, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29432322/acute-compartment-syndrome-an-expert-survey-of-orthopedic-trauma-association-ota-members
#8
Cory Collinge, Basem Attum, Paul Tornetta, William Obremskey, Jaimo Ahn, Gudrun Mirick, Andrew Schmidt, Clay Spitler, Chad Coles, Peter Krause
OBJECTIVES: The goal of this study was to describe current opinions of orthopedic trauma experts regarding acute compartment syndrome (ACS). DESIGN: Web-based survey SETTING:: N/A PARTICIPANTS:: Active Orthopedic Trauma Association (OTA) members METHODS:: A 25 item web-based questionnaire was advertised to active members of the OTA. Using a cross-sectional survey study design, we evaluated the perceived importance of ACS, as well as preferences in diagnosis and treatment...
January 24, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29428486/intra-articular-knee-implantation-of-autologous-bone-marrow-derived-mesenchymal-stromal-cells-in-rheumatoid-arthritis-patients-with-knee-involvement-results-of-a-randomized-triple-blind-placebo-controlled-phase-1-2-clinical-trial
#9
Soraya Shadmanfar, Narges Labibzadeh, Mohsen Emadedin, Neda Jaroughi, Vajiheh Azimian, Soura Mardpour, Fatemeh Abbasi Kakroodi, Tina Bolurieh, Seyyedeh Esmat Hosseini, Mohammad Chehrazi, Maryam Niknejadi, Hossein Baharvand, Farhad Gharibdoost, Nasser Aghdami
BACKGROUND: In this study, we intend to assess the safety and tolerability of intra-articular knee implantation of autologous bone marrow-derived mesenchymal stromal cells (MSCs) in patients with rheumatoid arthritis (RA) and to determine the preliminary clinical efficacy data in this population. The trial registration numbers are as follows: Royan Institute Ethics Committee: AC/91/1133; NCT01873625. METHODS: This single-center, randomized, triple-blind, placebo-controlled phase 1/2 clinical trial randomized RA patients with knee involvement to receive either an intra-articular knee implantation of 40 million autologous bone marrow-derived MSCs per joint or normal saline (placebo)...
February 7, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29427733/extraesophageal-symptoms-and-diseases-attributed-to-gerd-where-is-the-pendulum-swinging-now
#10
Michael F Vaezi, David Katzka, Frank Zerbib
BACKGROUND AND AIMS: The purpose of this review is to outline the recent developments in the field of extraesophageal reflux disease and provide clinically relevant recommendations. METHODS: The recommendations outlined in this review are based on expert opinion and on relevant publications from PubMed and EMbase. The Clinical Practice Updates Committee of the American Gastroenterological Association proposes the following recommendations: 1. The role of a gastroenterologist in patients referred for evaluation of suspected extra esophageal symptom is to assess for gastroesophageal etiologies that could contribute to the presenting symptoms...
February 7, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29413742/current-evidence-regarding-the-diagnostic-methods-for-pediatric-lumbar-spondylolisthesis-a-report-from-the-scoliosis-research-society-evidence-based-medicine-committee
#11
Han Jo Kim, Charles H Crawford, Charles Ledonio, Shay Bess, A Noelle Larson, Marilyn Gates, Matthew Oetgen, James O Sanders, Douglas Burton
STUDY DESIGN: Structured literature review. OBJECTIVES: The Scoliosis Research Society (SRS) requested an assessment of the current state of peer-reviewed evidence regarding pediatric lumbar spondylolisthesis with the goal of identifying what is known and what gaps remain in further understanding the diagnostic methods for pediatric spondylolisthesis. SUMMARY OF BACKGROUND DATA: Spondylolisthesis in the lumbar spine is common among children and adolescents and no formal synthesis of the published literature regarding diagnostic methods has been previously performed...
March 2018: Spine Deformity
https://www.readbyqxmd.com/read/29381232/categorization-of-fetal-external-findings-in-developmental-toxicology-studies-by-the-terminology-committee-of-the-japanese-teratology-society
#12
REVIEW
Yuko Izumi, Yojiro Ooshima, Kazuhiro Chihara, Michio Fujiwara, Yoshihiro Katsumata, Kohei Shiota
Categorization of fetal external findings in common laboratory animals, intended to make the agreement at Berlin Workshop in 2014 more practical, was proposed by the Terminology Committee of the Japanese Teratology Society (JTS) at the Workshop in the 55th JTS Annual Meeting in 2015. In the Workshop, 73 external findings, which had been categorized as "Gray zone" anomalies but not as "Malformation" or "Variation" in the 2014 Berlin Workshop, were discussed and classified as "Malformation", "Non-structural abnormality", "Variation", and "Not applicable...
January 30, 2018: Congenital Anomalies
https://www.readbyqxmd.com/read/29380676/the-current-role-of-glycopeptides-in-the-treatment-of-methicillin-resistant-staphylococcus-aureus-mrsa-infections-in-not-neutropenic-adults-the-viewpoint-of-a-group-of-italian-experts
#13
Ercole Concia, Claudio Viscoli, Valerio Del Bono, Maddalena Giannella, Matteo Bassetti, Giuseppe Francesco De Rosa, Emanuele Durante Mangoni, Silvano Esposito, Massimo Giusti, Paolo Grossi, Francesco Menichetti, Federico Pea, Nicola Petrosillo, Mario Tumbarello, Stefania Stefani, Mario Venditti, Pierluigi Viale
Staphylococcus aureus is still an important problem in clinical and therapeutic area, worldwide. In Italy, in recent years, methicillin resistance remained stable, yet considerably high, the percentage of strains of MRSA being around 40%. It was deemed interesting and timely to carry out a consensus conference using the RAND/UCLA method to collect the opinion of a group of experts in infectious diseases on the role of glycopeptides in the management of MRSA infections within several clinical scenarios and namely in pneumonia, bacteremia and endocarditis, joint replacement infections, skin and soft tissue infections, diabetic foot, abdominal infections and central nervous system infections...
January 30, 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29370048/acog-committee-opinion-no-730-fatigue-and-patient-safety
#14
(no author information available yet)
Fatigue and sleep deprivation may affect a health care provider's skills and communication style, and also may affect clinical outcomes. The National Sleep Foundation recommends 7-9 hours of sleep per night for an adult. However, there are no current guidelines limiting the volume of deliveries and procedures performed by a single individual or on the length of time he or she may be on call. Medical literature has shown that even a single night of missed sleep measurably affects cognitive performance. When adults do not sleep at least 5 hours per night, language and numeric skills, retention of information, short-term memory, and concentration all decrease on standardized testing...
February 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29370046/acog-committee-opinion-no-730-summary-fatigue-and-patient-safety
#15
(no author information available yet)
Fatigue and sleep deprivation may affect a health care provider's skills and communication style, and also may affect clinical outcomes. The National Sleep Foundation recommends 7-9 hours of sleep per night for an adult. However, there are no current guidelines limiting the volume of deliveries and procedures performed by a single individual or on the length of time he or she may be on call. Medical literature has shown that even a single night of missed sleep measurably affects cognitive performance. When adults do not sleep at least 5 hours per night, language and numeric skills, retention of information, short-term memory, and concentration all decrease on standardized testing...
February 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29370038/committee-opinion-no-485-prevention-of-early-onset-group-b-streptococcal-disease-in-newborns-correction
#16
(no author information available yet)
No abstract text is available yet for this article.
February 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29353505/expanded-access-to-investigational-drugs-balancing-patient-safety-with-potential-therapeutic-benefits
#17
Elena Fountzilas, Rabih Said, Apostolia M Tsimberidou
Expanded access is the use of an investigational product by patients with serious medical conditions without participation in a clinical trial. It is a complicated process involving the collaboration of many parties and pharmaceutical companies. Ongoing efforts focus on accelerating expanded access procedures in the best interest of patients with cancer. Areas covered: We review the regulatory and ethical challenges encountered in efforts to optimize expanded access. Expert opinion: In the era of personalized medicine, patients may benefit from novel therapeutic agents that demonstrate encouraging results in early studies...
January 22, 2018: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29341979/wilson-s-disease-in-children-a-position-paper-by-the-hepatology-committee-of-the-european-society-for-paediatric-gastroenterology-hepatology-and-nutrition
#18
Piotr Socha, Wojciech Janczyk, Anil Dhawan, Ulrich Baumann, Lorenzo D'Antiga, Stuart Tanner, Raffaele Iorio, Pietro Vajro, Roderick Houwen, Björn Fischler, Antal Dezsofi, Nedim Hadzic, Loreto Hierro, Jörg Jahnel, Valérie McLin, Valerio Nobili, Francoise Smets, Henkjan J Verkade, Dominique Debray
BACKGROUND: Clinical presentations of Wilson's disease (WD) in childhood ranges from asymptomatic liver disease to cirrhosis or acute liver failure, whereas neurological and psychiatric symptoms are rare. The basic diagnostic approach includes serum ceruloplasmin and 24-hour urinary copper excretion. Final diagnosis of WD can be established using a diagnostic scoring system based on symptoms, biochemical tests assessing copper metabolism, and molecular analysis of mutations in the ATP7B gene...
February 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29333061/critical-appraisal-of-rome-iv-criteria-hypersensitive-esophagus-does-belong-to-gastroesophageal-reflux-disease-spectrum
#19
REVIEW
Leonardo Frazzoni, Marzio Frazzoni, Nicola de Bortoli, Salvatore Tolone, Irene Martinucci, Lorenzo Fuccio, Vincenzo Savarino, Edoardo Savarino
The Rome IV Committee introduced a major change in the classification of functional gastrointestinal disorders, proposing a more restrictive definition of gastroesophageal reflux disease (GERD). It was suggested that hypersensitive esophagus (HE) may sit more firmly within the functional realm. It was suggested that GERD diagnosis should be based upon abnormal acid exposure time (AET) only, implying no advantage of impedance-pH over pH monitoring. Symptom association probability (SAP), symptom index (SI) and heartburn relief with proton pump inhibitor (PPI) therapy were regarded as unreliable, whereas a lack of response to PPI was considered as evidence of functional heartburn...
January 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29324733/antibiotics-dispensed-to-privately-insured-pregnant-women-with-urinary-tract-infections-united-states-2014
#20
Elizabeth C Ailes, April D Summers, Emmy L Tran, Suzanne M Gilboa, Kathryn E Arnold, Dana Meaney-Delman, Jennita Reefhuis
Urinary tract infections (UTIs) occur in about 8% of pregnant women, and untreated UTIs can have serious consequences, including pyelonephritis, preterm labor, low birth weight, and sepsis (1). Pregnant women are typically screened for UTIs during early pregnancy, and those with bacteriuria are treated with antibiotics (1,2). Antibiotic stewardship is critical to improving patient safety and to combating antibiotic resistance. Because of the potential risk for birth defects, including anencephaly, heart defects, and orofacial clefts, associated with use of sulfonamides and nitrofurantoin during pregnancy (3), a 2011 committee opinion from the American College of Obstetricians and Gynecologists (ACOG) recommended that sulfonamides and nitrofurantoin may be prescribed in the first trimester of pregnancy only when other antimicrobial therapies are deemed clinically inappropriate (4)...
January 12, 2018: MMWR. Morbidity and Mortality Weekly Report
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