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https://www.readbyqxmd.com/read/28100120/hybrid-stage-i-procedure-as-initial-palliation-for-neonate-with-hypoplastic-left-heart-syndrome-and-right-congenital-diaphragmatic-hernia
#1
Draginja Cvetkovic, Joseph Giamelli, Michael Lyew, Markus Erb, Suvro Sett, Youmna DiStefano
During the past decade, a hybrid procedure has emerged and dramatically evolved as an alternative stage I palliation to the conventional Norwood procedure in neonates with hypoplastic left heart syndrome (HLHS). The hybrid approach avoids the need for cardiopulmonary bypass (CPB) utilizing stenting of the arterial duct and bilateral pulmonary artery banding. Cerebral and coronary perfusion pressure is maintained, and the pulmonary vasculature is protected from higher systemic pressure. Elimination of risks associated with CPB gains vital time to stabilize the patient and correct coexisting noncardiac anomalies and allows growth in preparation for the later stages of the Fontan pathway...
January 1, 2017: Seminars in Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28095996/antenatal-predictors-of-outcome-in-prenatally-diagnosed-congenital-diaphragmatic-hernia-cdh
#2
REVIEW
Titilayo Oluyomi-Obi, Verena Kuret, Pramod Puligandla, Abhay Lodha, Helen Lee-Robertson, Kovid Lee, David Somerset, Joann Johnson, Greg Ryan
BACKGROUND: Pulmonary hypoplasia is the main cause of mortality in isolated congenital diaphragmatic hernia (CDH) and its prediction is paramount when counseling parents. We sought to identify antenatal parameters that predicted neonatal mortality in CDH. METHOD: Search was conducted in MEDLINE, EMBASE, Cochrane Database of Systematic reviews, PubMed, Scopus, and Web of Science on the ability of lung-to-head ratio (LHR), observed-to-expected LHR (o/e LHR), total fetal lung volume (TFLV), o/e TFLV, percentage predicted lung volume (PPLV) and degree of liver herniation to predict neonatal morbidity and mortality in fetuses with CDH...
December 21, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28078737/3d-assessment-of-the-umbilical-vein-deviation-angle-uvda-for-the-prediction-of-liver-herniation-in-left-congenital-diaphragmatic-hernia
#3
Nicola Volpe, Eleonora Mazzone, Brunella Muto, Alice Suprani, Tiziana Fanelli, Christine Tita Kaihura, Andrea Dall'Asta, Giuseppe Pedrazzi, Carmine Del Rossi, Enrico Maria Silini, Cinzia Magnani, Paolo Volpe, Tullio Ghi, Tiziana Frusca
OBJECTIVES: To introduce a new sonographic marker of intrathoracic liver herniation in fetuses with left congenital diaphragmatic hernia (CDH) METHODS: In a consecutive series of fetuses with isolated CDH an ultrasound volume of the fetal abdomen was acquired. On this the offline calculation of the angle formed by the midline of the abdomen (joining the center of the vertebral body to the abdominal insertion of the umbilical cord) and a second line joining the center of the vertebral body to the intra-abdominal convexity of the umbilical vein was carried out (Umbilical Vein Deviation Angle or UVDA)...
January 12, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28062914/determination-of-kinetics-and-heat-of-hydrolysis-for-non-homogenous-substrate-by-isothermal-calorimetry
#4
D Tafoukt, A Soric, J-C Sigoillot, J-H Ferrasse
The competitiveness of the second-generation bioethanol by biotechnological process requires an effective and quantitative control of biochemical reactions. In this study, the potential of isothermal calorimetry technique to measure heat and kinetics of a non-homogeneous substrate enzymatic hydrolysis is intended. Using this technique, optimum temperature of the enzymes used for lignocellulosic molecules hydrolysis was determined. Thus, the amount of substrate-to-enzyme ratio was highlighted as an important parameter of the hydrolysis yield...
January 6, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28055024/prenatally-diagnosed-congenital-diaphragmatic-hernia-optimal-mode-of-delivery
#5
C M Burgos, B Frenckner, M Luco, M T Harting, P A Lally, K P Lally
OBJECTIVE: To evaluate if the delivery mode of infants with prenatally diagnosed congenital diaphragmatic hernia (CDH) affects the outcome. STUDY DESIGN: Data from the CDH Study Group database of infants with prenatal diagnosis between 2001-2015 were divided into four delivery mode groups: vaginal spontaneous, vaginal induced, elective caesarean section, and emergent caesarean section. Outcomes were analyzed in relation to the time of day of delivery and the gestational age at birth...
January 5, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28051921/tube-thoracostomy-at-the-time-of-congenital-diaphragmatic-hernia-repair-reassessing-the-risks-and-benefits
#6
Avraham Schlager, Kelly Arps, Ragavan Siddharthan, Matthew S Clifton
PURPOSE: Postoperative pneumothorax and effusion remain a concern following congenital diaphragmatic hernia (CDH) repair. Despite a recent trend away from intraoperative thoracostomy, few studies have actually compared outcomes with and without a chest tube. Rationale commonly cited for the more minimalistic approach include the presumed low likelihood of postoperative complications, potential risk of patch infection, and prolonged intubation. We evaluate these theories, as well as the implications of intraoperative chest tube (IOCT) placement...
January 4, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28051089/cadherin-26-is-an-alpha-integrin-binding-epithelial-receptor-regulated-during-allergic-inflammation
#7
J M Caldwell, M H Collins, K A Kemme, J D Sherrill, T Wen, M Rochman, E M Stucke, L Amin, H Tai, P E Putnam, M J Jiménez-Dalmaroni, M R Wormald, A Porollo, J P Abonia, M E Rothenberg
Cadherins (CDH) mediate diverse processes critical in inflammation, including cell adhesion, migration, and differentiation. Herein, we report that the uncharacterized cadherin 26 (CDH26) is highly expressed by epithelial cells in human allergic gastrointestinal tissue. In vitro, CDH26 promotes calcium-dependent cellular adhesion of cells lacking endogenous CDHs by a mechanism involving homotypic binding and interaction with catenin family members (alpha, beta, and p120), as assessed by biochemical assays. Additionally, CDH26 enhances cellular adhesion to recombinant integrin α4β7 in vitro; conversely, recombinant CDH26 binds αE and α4 integrins in biochemical and cellular functional assays, respectively...
January 4, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28043315/right-sided-congenital-diaphragmatic-hernia-and-myelomeningocele-a-rare-association
#8
Syed Rehan Ali, Shakeel Ahmed
Congenital diaphragmatic hernia (CDH) is a rare birth defect with a prevalence of < 0.5 per 1,000 live births. Majority of these defects are left-sided as most studies suggest that frequency of right-sided CDH was 10% of the total. The association of CDH with myelomeningocele (MMC) is extremely rare; as in Sweed's study of 116 consecutive cases of CDH, the incidence of associated MMC with CDH was stated as 4.3%. There has been one previous case report of leftsided CDH, MMC and hydrocephalus prenatally diagnosed; but to the best of authors' knowledge, this is the first reported case of the above constellation with a right-sided CDH diagnosed prenatally...
December 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28029369/management-and-outcomes-of-scoliosis-in-children-with-congenital-diaphragmatic-hernia
#9
Ryan M Antiel, John S Riley, Patrick J Cahill, Robert M Campbell, Lindsay Waqar, Lisa M Herkert, Natalie E Rintoul, William H Peranteau, Alan W Flake, N Scott Adzick, Holly L Hedrick
PURPOSE: The purpose of this study was to evaluate the management and outcomes of CDH patients with scoliosis. METHODS: From January 1996 to August 2015, 26 of 380 (7%) CDH patients were diagnosed with scoliosis. Six (23%) were prenatally diagnosed by ultrasound, and 9 (35%) were diagnosed postnatally. The remaining 11 (42%) developed scoliosis after discharge. Mean follow-up was 6.6years. RESULTS: Among the 15 patients with congenital scoliosis, there were 2 (13%) perinatal deaths...
September 15, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28018801/thoracoscopic-approach-for-congenital-diaphragmatic-hernia-a-useful-tool-in-diagnosis-and-treatment-of-unexpected-associated-lung-lesion
#10
Mario Lima, Michela Maffi, Tommaso Gargano, Giovanni Ruggeri, Michele Libri, Francesca Destro
We report the case of a neonate affected by prenatally diagnosed congenital diaphragmatic hernia (CDH), treated by thoracoscopy. During the procedure, we detected an associated extralobar pulmonary sequestration (EPS), which was preoperatively undiagnosed, and we removed it. EPS has been shown to be associated with CDH in up to 15 to 40% of cases. A possible explanation hypothesized is that pulmonary sequestration, which develops at 4 to 5 weeks of gestation, can disturb the fusion of the diaphragm and closure of the pleuroperitoneal canal...
December 2016: European Journal of Pediatric Surgery Reports
https://www.readbyqxmd.com/read/27986977/risk-factors-for-postoperative-mortality-in-congenital-diaphragmatic-hernia-a-single-centre-observational-study
#11
Darya Kadir, Helene Engstrand Lilja
BACKGROUND: The management of congenital diaphragmatic hernia (CDH) is a major challenge. The mortality is dependent on associated malformations, the severity of pulmonary hypoplasia, pulmonary hypertension and iatrogenic lung injury associated with aggressive mechanical ventilation. The aims of the study were to investigate the mortality over time in a single paediatric surgical centre, to compare the results with recent reports and to define the risk factors for mortality. METHODS: The medical records of infants with CDH from two time periods: 1995-2005 and 2006-2016 were reviewed...
December 16, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27977015/the-relationship-between-three-signs-of-fetal-magnetic-resonance-imaging-and-severity-of-congenital-diaphragmatic-hernia
#12
T Hattori, M Hayakawa, M Ito, Y Sato, K Tamakoshi, Y Kanamori, H Okuyama, N Inamura, S Takahashi, Y Fujino, T Taguchi, N Usui
OBJECTIVE: To seek a simple approach for prenatally classifying congenital diaphragmatic hernia (CDH) severity using fetal magnetic resonance imaging (MRI) markers. STUDY DESIGN: A retrospective, multicenter study using questionnaires to investigate fetal MRI findings. We included fetuses prenatally diagnosed with isolated left-sided CDH and delivered after 36 weeks of gestation. We focused on three fetal MRI morphological signs: incomplete pulmonary baseline (IPB), liver up (LU) and retrocardiac stomach (RCS)...
December 15, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27951457/radiologic-assessment-of-fetal-tracheal-balloon-occlusion
#13
Eric J Jordan, Vickie A Feldstein, Willieford Moses, Andrew S Phelps
Fetal endoscopic tracheal occlusion (FETO) is a novel technique to treat cases of isolated severe congenital diaphragmatic hernia (CDH). Although there are benefits of MRI over ultrasound in assessing lung volumes, it is unknown whether there are benefits of MRI for localizing the tracheal balloon. This is a retrospective study reviewing the imaging characteristics of FETO in patients who underwent both MRI and ultrasound exams done to localize tracheal balloons.
December 1, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27940787/congenital-diaphragmatic-hernia-defect-size-and-infant-morbidity-at-discharge
#14
Luke R Putnam, Matthew T Harting, Kuojen Tsao, Francesco Morini, Bradley A Yoder, Matías Luco, Pamela A Lally, Kevin P Lally
BACKGROUND AND OBJECTIVE: Survival for infants with congenital diaphragmatic hernia (CDH) has gradually improved, yet substantial burden of disease remains. Although larger CDH defect sizes increase mortality, the association between defect size and morbidity has not been reported. Our objective was to evaluate the association of defect size with pulmonary, neurologic, and gastrointestinal morbidity at the time of hospital discharge. METHODS: An international, prospective cohort study was performed...
November 2016: Pediatrics
https://www.readbyqxmd.com/read/27940779/neuropsychological-follow-up-after-neonatal-ecmo
#15
Raisa M Schiller, Marlous J Madderom, Jolanda J C M Reuser, Katerina Steiner, Saskia J Gischler, Dick Tibboel, Arno F J van Heijst, Hanneke IJsselstijn
OBJECTIVE: To assess the longitudinal development of intelligence and its relation to school performance in a nationwide cohort of neonatal extracorporeal membrane oxygenation (ECMO) survivors and evaluate predictors of outcome at 8 years of age. METHODS: Repeated measurements assessed intelligence of neonatal ECMO survivors at 2, 5, and 8 years (n = 178) with the use of validated, standardized instruments. Selective attention (n = 148) and type of education were evaluated in the 8-year-olds...
November 2016: Pediatrics
https://www.readbyqxmd.com/read/27934411/cadmium-compounds-with-an-n3c-atrane-motif-evidence-for-the-generation-of-a-cadmium-hydride-species
#16
Neena Chakrabarti, Serge Ruccolo, Gerard Parkin
Tris(2-pyridylthio)methane ([Tptm]H) has been employed to synthesize a series of cadmium carbatrane compounds that feature an [N3C] coordination environment. Specifically, [Tptm]H reacts with Cd[N(SiMe3)2]2 to afford [Tptm]CdN(SiMe3)2, which thereby provides access to other derivatives. For example, [Tptm]CdN(SiMe3)2 reacts with (i) CO2 to form {[Tptm]Cd(μ-NCO)}2 and (ii) Me3SiOH and Ph3SiOH to form {[κ(3)-Tptm]Cd(μ-OSiMe3)}2 and [Tptm]CdOSiPh3, respectively. The siloxide compound {[κ(3)-Tptm]Cd(μ-OSiMe3)}2 reacts with Me3SiX (X = Cl, Br, O2CMe) to give [Tptm]CdX, while the reaction with PhSiH3 in the presence of CO2 generates the formate complex, [Tptm]CdO2CH, thereby providing evidence for the generation of a proposed cadmium hydride intermediate, {[Tptm]CdH}...
December 5, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27926976/are-cytokines-useful-biomarkers-to-determine-disease-severity-in-neonates-with-congenital-diaphragmatic-hernia
#17
Thomas Schaible, Janine Reineke, Ludwig Gortner, Dominik Monz, Regine Schaffelder, Erol Tutdibi
Background This study investigates plasma cytokine levels in neonates with the more common left-sided congenital diaphragmatic hernia (CDH) and correlates them with severity of disease indicated by position of the liver. An intrathoracic part of liver is associated with higher need for extracorporeal membrane oxygenation (ECMO) and higher risk for chronic lung disease (CLD). Methods A total of 28 newborns with CDH were subdivided by their liver position in partially intrathoracic (n = 16) and only abdominal (n = 12) position...
December 7, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27920046/resuscitation-of-infants-with-congenital-diaphragmatic-hernia
#18
Anthony O'Rourke-Potocki, Kamal Ali, Vadivelam Murthy, Anthony Milner, Anne Greenough
OBJECTIVE: To determine whether the respiratory response to resuscitation in infants with congenital diaphragmatic hernia (CDH) as measured by a respiratory function monitor differed between those who did and did not survive. DESIGN: Observational study. SETTING: Tertiary perinatal centre. PATIENTS: Thirty-eight infants born at 34 weeks of gestation or greater and diagnosed antenatally with a CDH. INTERVENTIONS: Expiratory tidal volume (VTe), peak inflation pressure (PIP) and end-tidal carbon dioxide level (ETCO2) were simultaneously recorded during resuscitation using a respiratory function monitor...
December 5, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27912974/pulmonary-function-and-nutritional-morbidity-in-children-and-adolescents-with-congenital-diaphragmatic-hernia
#19
Beth Haliburton, Marialena Mouzaki, Monping Chiang, Vikki Scaini, Margaret Marcon, Wenming Duan, David Wilson, Priscilla Pl Chiu, Theo J Moraes
BACKGROUND: Malnutrition is common among congenital diaphragmatic hernia (CDH) survivors and may result from elevated respiratory effort. We evaluated body mass index (BMI), measured resting energy expenditure (mREE) and pulmonary function test (PFT) results in children and adolescents with CDH to determine if there is a correlation. METHODS: With ethics approval (REB# 1000035323), anthropometrics, indirect calorimetry (IC) results and PFTs were collected from patients 5-17years of age during CDH clinic visits between 2000 and 2016...
November 14, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27902503/bedside-placement-of-the-postpyloric-tube-in-infants
#20
Patricia Clifford, Elizabeth Ely, Lauren Heimall
BACKGROUND: Patients in the neonatal intensive care unit are a vulnerable population with specific nutritional requirements, which include increased protein and caloric needs for adequate growth. Some infants cannot tolerate gastric feeds and need to have postpyloric feeds to grow. Placement of a postpyloric tube can be done by gastric insufflation. Gastric insufflation is a technique where air is inserted into the stomach as a nasogastric tube is advanced through the pylorus to the duodenum...
November 29, 2016: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
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