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https://www.readbyqxmd.com/read/28527042/parenting-stress-among-parents-of-children-with-congenital-diaphragmatic-hernia
#1
Elin Öst, Margret Nisell, Björn Frenckner, Carmen Mesas Burgos, Maria Öjmyr-Joelsson
PURPOSE: The aim of this study was to examine parental stress among parents of children with congenital diaphragmatic hernia (CDH). METHODS: Between 2005 and 2009, a total of 51 children with CDH were treated at Astrid Lindgren Children's Hospital. The survival rate at discharge was 86% and long-term survival rate 80%. One parent each of the long-term survivors (41 children) was included in the present study, and 34 parents (83%) agreed to participate. Participants received the Swedish Parenthood Stress Questionnaire (SPSQ)...
May 19, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28496499/psychiatric-comorbidities-and-environmental-triggers-in-patients-with-chronic-daily-headache-a-lifestyle-study
#2
Fakhrudin Faizi, Abbas Tavallaee, Aboulfazl Rahimi, Masoud Saghafinia
Objective: Patients with chronic daily headache (CDH) suffer from several significant psychiatric comorbidities and have unhealthy lifestyle. We aimed at studying psychiatric comorbidities, environmental triggers, lifestyle factors, and intensity of CDH in patients referred by the department of neurology from 2011 to 2014. Method: Through medical and psychiatric interviews and using 0 to 10 visual analogue scale (VAS), we assessed patients with CDH, using a checklist, to elicit psychiatric comorbidities, intensity of CDH, environmental factors, and lifestyle derangement...
January 2017: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/28493419/support-for-alcohol-policies-from-drinkers-in-the-city-of-tshwane-south-africa-data-from-the-international-alcohol-control-study
#3
Charles D H Parry, Pamela Trangenstein, Carl Lombard, David H Jernigan, Neo K Morojele
INTRODUCTION AND AIMS: South Africa is considering a range of alcohol policy reforms. This study aims to determine the magnitude of public support for 13 alcohol policies in the Tshwane Metropolitan Municipality and whether this varies by demographic factors and heavy drinking status. DESIGN AND METHODS: Data are from the South African arm of the International Alcohol Control study, a household survey of adult drinkers using a multistage stratified cluster random sampling design...
May 10, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28489671/closer-look-at-the-nutritional-outcomes-of-patients-after-primary-repair-of-congenital-diaphragmatic-hernia
#4
Lan T Vu, Carrie McFarland, Barbara Bratton, Hanmin Lee
OBJECTIVES: We hypothesize that the patients after primary repair of congenital diaphragmatic hernia (CDH) can have poor nutritional outcomes and plan to identify risk factors to further stratify these patients. METHODS: Retrospective cohort of patients who had primary repair of CDH between 2000 and 2014 and had follow-up at our institution. Z-scores (weight for age and weight for length) were calculated using the WHO and CDC growth standards. RESULTS: For the 67 patients in the cohort, the median age at the time of repair was 3 days (IQR 2-5) and at the time of discharge was 20...
May 9, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28481127/fetal-cardiac-impairment-in-nitrofen-induced-congenital-diaphragmatic-hernia-postmortem-microcomputed-tomography-imaging-study
#5
Gloria Pelizzo, Valeria Calcaterra, Claudio Lombardi, Rossana Bussani, Vanessa Zambelli, Annalisa De Silvestri, Ana Custrin, Manuel Belgrano, Floriana Zennaro
INTRODUCTION: We assessed the post-mortem micro-CT utility to evaluate fetal cardiac impairment in nitrofen-induced congenital diaphragmatic hernia (CDH). METHODS: At 9.5d postconception (dpc), pregnant rats were exposed to nitrofen. At +18 and +21dpc, fetuses were harvested by cesarean section. Postmortem micro-CT and autopsy were performed. Fetuses were assigned to three experimental groups: Control group (C), Nitrofen group (N, exposition to nitrofen without CDH), CDH group...
May 8, 2017: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/28475336/on-the-performance-of-td-dft-for-excited-states-of-open-shell-transition-metal-compounds
#6
Bingbing Suo, Kaiyuan Shen, Zhendong Li, Wenjian Liu
Time-dependent density functional theory (TD-DFT) has been very successful in accessing low-lying excited states of closed-shell systems. However, it is much less so for excited states of open-shell systems: unrestricted Kohn-Sham based TD-DFT (U-TD-DFT) often produces physically meaningless excited states due to heavy spin contaminations, whereas restricted Kohn-Sham based TD-DFT often misses those states of lower energies. A much better variant is the explicitly spin-adapted TD-DFT (X-TD-DFT) [J. Chem. Phys...
May 5, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28473726/non-autotrophic-methanogens-dominate-in-anaerobic-digesters
#7
Atsushi Kouzuma, Maho Tsutsumi, Shun'ichi Ishii, Yoshiyuki Ueno, Takashi Abe, Kazuya Watanabe
Anaerobic digesters are man-made habitats for fermentative and methanogenic microbes, and are characterized by extremely high concentrations of organics. However, little is known about how microbes adapt to such habitats. In the present study, we report phylogenetic, metagenomic, and metatranscriptomic analyses of microbiomes in thermophilic packed-bed digesters fed acetate as the major substrate, and we have shown that acetoclastic and hydrogenotrophic methanogens that utilize acetate as a carbon source dominate there...
May 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28453882/the-validity-of-the-observed-to-expected-lung-to-head-ratio-in-congenital-diaphragmatic-hernia-in-an-era-of-standardized-neonatal-treatment-a-multicenter-study
#8
Kitty G Snoek, Nina C J Peters, Joost van Rosmalen, Arno F J van Heijst, Alex J Eggink, Esther Sikkel, René M Wijnen, Hanneke IJsselstijn, Titia E Cohen-Overbeek, Dick Tibboel
OBJECTIVE: To assess the predictive value of observed-to-expected lung-to-head ratio (O/E LHR) for survival and chronic lung disease (CLD) in survivors of left-sided congenital diaphragmatic hernia (CDH) in an era of standardized neonatal treatment, and to evaluate the predictive value of the O/E LHR trajectory for survival. METHODS: This retrospective cohort study was performed in two high-volume CDH centers in the Netherlands in prenatally detected, isolated left-sided CDH patients born between 2008-2014...
April 28, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28453870/clinically-relevant-discordances-identified-after-tertiary-reassessment-of-fetuses-with-isolated-congenital-diaphragmatic-hernia
#9
Elisa Done, Leonardo Gucciardo, Tim Van Mieghem, Koen Devriendt, Karel Allegaert, Paul Brady, Roland Devlieger, Luc De Catte, Liesbeth Lewi, Jan Deprest
OBJECTIVE: Fetoscopic Endoluminal Tracheal Occlusion (FETO) may improve outcome of severe isolated Congenital Diaphragmatic Hernia (iCDH). We aimed to identify any discrepancy between initial assessment at the referring hospital and the evaluation at the fetal surgery center, and to document parental decisions following counseling for fetal surgery. DESIGN: Single centre retrospective study on patients with presumed iCDH either referred for assessment and counseling or referred for fetal surgery...
April 28, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28444651/-mri-based-ratio-of-fetal-lung-to-body-volume-as-new-prognostic-marker-for-chronic-lung-disease-in-patients-with-congenital-diaphragmatic-hernia
#10
Melissa M Winkler, Meike Weis, Claudia Henzler, Christel Weiß, Sven Kehl, Stefan O Schoenberg, Wolfgang Neff, Thomas Schaible
Background Our aim was to evaluate the prognostic value of magnetic resonance imaging (MRI)-based ratio of fetal lung volume (FLV) to fetal body volume (FBV) as a marker for development of chronic lung disease (CLD) in fetuses with congenital diaphragmatic hernia (CDH). Patients and Methods FLV and FBV were measured and the individual FLV/FBV ratio was calculated in 132 fetuses. Diagnosis of CLD was established following prespecified criteria and graded into mild/moderate/severe if present. Logistic regression analysis was used to calculate the probability of postnatal development of CLD in dependence of the FLV/FBV ratio...
March 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28435022/maternal-separation-induces-hippocampal-changes-in-cadherin-1-cdh-1-mrna-and-recognition-memory-impairment-in-adolescent-mice
#11
Lucas Araújo de Azeredo, Luis Eduardo Wearick-Silva, Thiago Wendt Viola, Saulo Gantes Tractenberg, Anderson Centeno-Silva, Rodrigo Orso, Nadja Schröder, Timothy William Bredy, Rodrigo Grassi-Oliveira
In rodents, disruption of mother-infant attachment induced by maternal separation (MS) is associated with recognition memory impairment and long-term neurobiological consequences. Particularly stress-induced modifications have been associated to disruption of cadherin (CDH) adhesion function, which plays an important role in remodeling of neuronal connection and synaptic plasticity. This study investigated the sex-dependent effect of MS on recognition memory and mRNA levels of classical type I and type II CDH and the related β -catenin (β -Cat) in the hippocampus and prefrontal cortex of late adolescent mice...
April 20, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28429928/a-dual-enzyme-hydrogen-peroxide-generation-machinery-in-hydrogels-supports-antimicrobial-wound-treatment
#12
Daniela Huber, Gregor Tegl, Anna Mensah, Bianca Beer, Martina Baumann, Nicole Borth, Christoph Sygmund, Roland Ludwig, Georg M Guebitz
The aging population and accompanying diseases like diabetes resulted in an increased occurrence of chronic wounds. Topical wound treatment with antimicrobial agents to inhibit bacterial invasion and promote wound healing is often associated with difficulties. Here, we investigated the potential of succinyl chitosan (SC)-carboxymethyl cellulose (CMC) hydrogels which constantly release clinically relevant levels of hydrogen peroxide (H2O2). CMC hydrogel matrix was in situ converted by limited hydrolysis by a cellulase into substrates accepted by cellobiose dehydrogenase (CDH) for continuous production of H2O2 (30 μM over 24 h)...
April 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28422868/meta-analysis-of-possible-role-of-cadherin-gene-methylation-in-evolution-and-prognosis-of-hepatocellular-carcinoma-with-a-prisma-guideline
#13
Chunxiao Zhu, Xuefeng Feng, Guoliang Ye, Tao Huang
BACKGROUND: Cadherins (CDHs) have been reported to be associated with cancer. However, the clinical significance of CDH gene methylation in hepatocellular carcinoma (HCC) remains unclear. METHODS: Based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement criteria, available studies were identified from online electronic database. The overall odds ratio (OR) and the corresponding 95% confidence interval (95% CI) were calculated and analyzed...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28410786/the-use-of-ecmo-for-gastroschisis-and-omphalocele-two-decades-of-experience
#14
Joanne E Baerg, Arul Thirumoorthi, Andrew O Hopper, Edward P Tagge
PURPOSE: The aim was to review the respiratory failure causes and outcomes of infants with omphalocele or gastroschisis receiving ECMO and reported to the Extracorporeal Life Support Organization (ELSO). METHODS: Gastroschisis and omphalocele infants supported with ECMO and reported to the ELSO Registry between 1992 and 2015 were retrospectively reviewed. Clinical variables, diagnosis of respiratory failure (pulmonary hypertension (PHN), congenital heart defects (CHD), congenital diaphragmatic hernia (CDH), and sepsis), and outcomes were recorded...
March 16, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28398654/survival-disparities-associated-with-congenital-diaphragmatic-hernia
#15
Cynthia F Hinton, Csaba Siffel, Adolfo Correa, Stuart K Shapira
BACKGROUND: We assessed sociodemographic and clinical factors that are associated with survival among infants with congenital diaphragmatic hernia (CDH). METHODS: Using data from the Metropolitan Atlanta Congenital Defects Program, we ascertained 150 infants born with CDH between 1979 and 2003 and followed via linkage with state vital records and the National Death Index. Kaplan-Meier survival probabilities and adjusted hazard ratios (HRs) were calculated for socioeconomic and clinical characteristics...
April 10, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28389079/safety-and-tolerability-of-subcutaneous-treprostinil-in-newborns-with-congenital-diaphragmatic-hernia-and-life-threatening-pulmonary-hypertension
#16
E Carpentier, S Mur, E Aubry, L Pognon, T Rakza, F Flamein, D Sharma, P Tourneux, L Storme
BACKGROUND: Prolonged pulmonary hypertension (PH) is highly predictive for pulmonary morbidity and death in infants with congenital diaphragmatic hernia (CDH). OBJECTIVES: To report the effects and tolerability of subcutaneous treprostinil in newborns with severe CDH and late life-threatening PH. METHODS: We recorded clinical and echocardiography data before and after starting subcutaneous treprostinil, on patients with severe CDH and late PH, refractory to inhaled nitric oxide and oral sildenafil...
March 28, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28385427/percent-predicted-lung-volume-changes-on-fetal-magnetic-resonance-imaging-throughout-gestation-in-congenital-diaphragmatic-hernia
#17
Hester F Shieh, Carol E Barnewolt, Jay M Wilson, David Zurakowski, Susan A Connolly, Judy A Estroff, Jill Zalieckas, C Jason Smithers, Terry L Buchmiller
PURPOSE: Percent predicted lung volume (PPLV)<15% on fetal MRI predicts high-risk CDH. Potential changes in PPLV throughout gestation and impact on risk stratification are unknown. We reviewed CDH patients with serial fetal MRIs to follow PPLV and determine correlation with postnatal outcomes. METHODS: CDH patients with serial fetal MRIs from 2005 to 2015 were included. We recorded prenatal MRI gestational age (GA) and PPLV, postnatal ECMO use, and survival. Data were analyzed by logistic regression and Fisher's exact test...
March 16, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28374686/-the-optimization-of-management-of-chronic-daily-headache-patients
#18
V A Golovacheva, V A Parfenov, G R Tabeeva, V V Osipova, A B Smulevich, A V Andryushchenko, A A Golovacheva
AIM: To optimize the management of chronic daily headache (CDH) using cognitive-behavioral therapy (CBT). MATERIAL AND METHODS: The study included 90 patients (76 women and 14 men), aged from 23 to 78 years (mean age 46.71±11.99) with primary forms of CDH. The patients were followed-up by the neurologist during 12 months, psychological characteristics were studied together with the psychiatrist. Patients received combined treatment, including optimized pharmacotherapy, educational program, relaxation training, CBT and exercise therapy...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28370263/fetal-left-sided-cardiac-structural-dimensions-in-left-sided-congenital-diaphragmatic-hernia-association-with-severity-and-impact-on-postnatal-outcomes
#19
Joshua A Kailin, Gurpreet S Dhillon, Shiraz A Maskatia, Darrell L Cass, Alireza A Shamshirsaz, Amy R Mehollin-Ray, Christopher I Cassady, Nancy A Ayres, Yunfei Wang, Michael A Belfort, Oluyinka O Olutoye, Rodrigo Ruano
OBJECTIVES: Fetuses with congenital diaphragmatic hernia (CDH) demonstrate varying degrees of left heart hypoplasia. Our study assesses the relationship between fetal left-sided cardiac structural dimensions, lung size, percentage liver herniation, lung-to-head ratio, postnatal left-sided cardiac structural dimensions, and postnatal outcomes. METHODS: We performed a retrospective cohort study of fetuses with left-sided CDH who had prenatal echocardiographic, ultrasound, and magnetic resonance imaging examinations at our institution between January 2007 and March 2015...
March 31, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28363469/down-regulation-of-n-deacetylase-n-sulfotransferase-1-signaling-in-the-developing-diaphragmatic-vasculature-of-nitrofen-induced-congenital-diaphragmatic-hernia
#20
Toshiaki Takahashi, Florian Friedmacher, Julia Zimmer, Prem Puri
BACKGROUND: Congenital diaphragmatic hernia (CDH) has been attributed to various developmental abnormalities of the underlying tissue components. N-deacetylase-N-sulfotransferase-1 (Ndst1) is a strongly expressed biosynthetic enzyme in endothelial cells, which has recently been identified as an important factor during diaphragmatic vascularization. Loss of endothelial Ndst1 has been demonstrated to cause angiogenic defects in the developing diaphragm and disrupt normal diaphragmatic development...
March 18, 2017: Journal of Pediatric Surgery
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