Eline J Arends, Soufian Meziyerh, Dirk Jan A R Moes, Sylvia W A Kamerling, Sandra van der Kooy, Natacha S Ogando, Eric J Snijder, Martijn van Hemert, Leo G Visser, Mariet C W Feltkamp, Eric C J Claas, Ton J Rabelink, Cees van Kooten, Aiko P J de Vries, Y K Onno Teng
INTRODUCTION: Immunocompromised kidney patients are at increased risk of prolonged SARS-CoV-2 infection and related complications. Preclinical evidence demonstrates a more potent inhibitory effect of voclosporin on SARS-CoV-2 replication than tacrolimus in vitro . We investigated the potential antiviral effects of voclosporin on SARS-CoV-2 in immunocompromised patients. METHODS: First, we conducted a prospective, randomized, open-label, proof-of-concept study in 20 kidney transplant recipients (KTRs) on tacrolimus-based immunosuppression who contracted mild to moderate SARS-CoV-2 infection...
December 2023: KI Reports