Alexa Torrens, Pritam Roy, Lin Lin, Cindy Vu, Dakota Grimes, Victoria C Inshishian, Johanna S Montesinos, Faizy Ahmed, Stephen V Mahler, Marylin A Huestis, Aditi Das, Daniele Piomelli
Introduction: Studies in rodent models have shown that adolescent exposure to Δ9 -THC, the psychotropic constituent of cannabis, produces long-lasting alterations in brain function and behavior. However, our understanding of how age and sex might influence the distribution and metabolism of THC in laboratory rodents is still incomplete. In the present report, we provide a comparative analysis of the pharmacokinetic (PK) properties of THC in adolescent and adult rats of both sexes, and outline several dissimilarities across these groups...
March 28, 2022: Cannabis and Cannabinoid Research