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https://www.readbyqxmd.com/read/28926405/elevated-ischemic-stroke-risk-among-women-living-with-hiv-infection
#1
Felicia C Chow, Susan Regan, Markella V Zanni, Sara E Looby, Cheryl D Bushnell, James B Meigs, Steven K Grinspoon, Steve K Feske, Virginia A Triant
OBJECTIVE: To determine if the greater risk of ischemic stroke observed in women living with HIV infection (WLWH) compared with HIV-uninfected women persists after accounting for both traditional and sex-specific stroke risk factors. METHODS: We performed an observational cohort study of WLWH (n = 1,214) and demographics-matched HIV-uninfected women (n = 12,041) seen between 1996 and 2011 at two tertiary care hospitals in Boston. We used Cox proportional hazards regression analyses to model time to ischemic stroke, adjusting first for demographics and traditional stroke risk factors and then for sex-specific stroke risk factors, including menopause and estrogen use...
September 18, 2017: AIDS
https://www.readbyqxmd.com/read/28924277/clinical-outcomes-of-prophylactic-platelet-transfusion-in-patients-with-dengue-a-retrospective-study-of-patients-at-a-tertiary-care-hospital-in-karachi
#2
Sher Muhammad Sethi, Ayesha Khalil, Muhammad Rashid Naseem Khan, Adeel Khatri, Asif Jan Muhammad, Ghulam Murtaza
OBJECTIVE: To determine the benefit of prophylactic platelet transfusion on clinical outcomes in patients with dengue fever. METHODS: The retrospective cohort study was conducted at Patel Hospital, Karachi, and comprised record of patients fulfilling World Health Organisation's diagnostic criteria for dengue between 2009 and 2015. We excluded patients with known auto-immune thrombocytopenia, isolated infection with a pathogen other than dengue virus, drug-induced thrombocytopenia and patients requiring therapeutic transfusion...
September 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28923373/outbreak-of-burkholderia-cepacia-bacteraemia-in-a-tertiary-care-centre-due-to-contaminated-ultrasound-probe-gel
#3
Rehab Abdelfattah, Suliman Aljumaah, Ahmed Alqahtani, Sahar Althawadi, Irene Barron, Saleh Almofada
BACKGROUND: Burkholderia cepacia is a significant opportunistic organism in hospitalized and immunocompromised patients, particularly in cystic fibrosis [1] AIMS: We describe the epidemiological investigation of an outbreak of B. cepacia bacteraemia. METHODS: The study examined 14 patients during their admission to three ICUs (Intensive Care Units) in a tertiary care hospital between January-June 2016. The outbreak involved 9 (57%) female and 6 (43%) male patients...
September 15, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28922488/isolation-of-rhodotorula-mucilaginosa-from-blood-cultures-in-a-tertiary-care-hospital
#4
Iker Falces-Romero, Emilio Cendejas-Bueno, María Pilar Romero-Gómez, Julio García-Rodríguez
BACKGROUND: Rhodotorula species have traditionally been considered as one of common non-virulent environmental inhabitant. They have emerged as an opportunistic pathogen, particularly in immunocompromised hosts and most infections have been associated with intravenous catheters in these patients. OBJECTIVE: We review the isolates in blood cultures of Rhodotorula mucilaginosa in our Hospital. We describe the demographic and clinical features of the cases and the antifungal susceptibility profiles of the isolates...
September 18, 2017: Mycoses
https://www.readbyqxmd.com/read/28921529/metastatic-spine-tumor-surgery-does-perioperative-blood-transfusion-influence-postoperative-complications
#5
Aye Sandar Zaw, Shashidhar B Kantharajanna, Karthikeyan Maharajan, Barry Tan, Amarasinghe A Saparamadu, Naresh Kumar
BACKGROUND: The question of independent association between allogeneic blood transfusion (ABT) and postoperative complications in cancer surgeries has been controversial and remains so. In metastatic spine tumor surgery (MSTS), previous studies investigated the influence of ABT on survival, but not on postoperative complications. We aimed to evaluate the influence of perioperative ABT on postoperative complications and infections in patients undergoing MSTS. STUDY DESIGN AND METHODS: This retrospective study included 247 patients who underwent MSTS at a single tertiary institution between 2005 and 2014...
September 16, 2017: Transfusion
https://www.readbyqxmd.com/read/28919606/current-trends-of-using-antimicrobials-and-their-sensitivity-pattern-in-infectious-cases-at-department-of-orthopedics-in-a-tertiary-care-hospital
#6
M M Sarker, S K Saha, S Saha, A N Naushad, S Ajmery, P Roy, M S Chowdhury, L Mukta
This cross-sectional descriptive study was carried out to analyse the current trends of using antimicrobials at orthopaedics department in different surgical procedures and observe the antimicrobial sensitivity pattern of infective organisms in postoperative wound infection cases at the department of Orthopaedics, Mymensingh Medical College Hospital with collaboration of department of Pharmacology and Therapeutics in Mymensingh Medical College, Mymensingh from January 2016 to December 2016. Among 253 orthopaedics surgical cases Penicillins, Cephalosporins, and Aminoglycoside group were commonly prescribed antimicrobials that had been use postoperatively in most of the Orthopaedics cases...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28919603/current-trends-of-using-antimicrobials-at-obstetrics-and-gynaecology-department-in-a-tertiary-care-hospital
#7
M M Islam, S K Saha, S Saha, U A Wahid, R R Gomes, K S Ahmed, A N Naushad, S E Suchi, C Saha, D Mondal
This cross-sectional descriptive study was done to analyse the current trends of using antimicrobials in various surgical procedures at Obstetrics and Gynaecology department in Mymensingh Medical College Hospital, Mymensingh from July 2014 to June 2015. Among 300 postoperative obstetrics and gynaecological surgery cases, samples were selected as non-random purposive selection method where pattern of using antimicrobials were analysed by SPSS method 20.1 versions. The incidence of antimicrobial resistance is on continued rise with a threat to return to the pre-antibiotic era...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28918832/streptococcus-anginosus-group-bacterial-infections
#8
Tasaduq Fazili, Scott Riddell, Deanna Kiska, Tim Endy, Luca Giurgea, Calden Sharngoe, Waleed Javaid
BACKGROUND: The Streptococcus anginosus group (SAG) causes a variety of infections in adults. To better understand the burden of SAG infections and their associated morbidity and mortality, we conducted a retrospective analysis of these infections in adults at a tertiary care center. METHODS: A retrospective review of all cultures positive for SAG in adults and a corresponding review of the patients' medical records were conducted at a tertiary care facility in central New York...
September 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28918667/poor-outcomes-among-elderly-patients-hospitalized-for-influenza-like-illness
#9
Mine Durusa Tanriover, Tülay Bagci Bosi, Lale Ozisik, Emre Bilgin, Özlem Güzel Tunçcan, Özge Özgen, Necla Tülek, Metin Özsoy, Hasan Tezer, Tugba Bedir Demirdağ, Ates Kara, Sevgen Tanir Basaranoglu, Kubra Aykac, Aslinur Ozkaya-Parlakay, Belgin Gulhan, Serhat Unal
BACKGROUND AND OBJECTIVE: Global Influenza Hospital Surveillance Network is a worldwide initiative that aims to document the burden of influenza infections among acute admissions and the vaccine effectiveness in particular countries. As a partner of this platform, we aimed to determine the frequency of influenza infections among acute admissions with influenza like illness and the outcomes of the enrolled patients during the 2015-2016 influenza season in selected hospitals in Turkey. PATIENTS AND METHODS: The investigators screened the hospital admission registries, chart review or available records, and screened all patients hospitalized in the previous 24-48 hours or overnight in the predefined wards or emergency room...
September 18, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28917998/clinical-characteristics-and-outcomes-in-polyarticular-septic-arthritis
#10
Sarah B Lieber, Mary Louise Fowler, Clara Zhu, Andrew Moore, Robert H Shmerling, Ziv Paz
OBJECTIVES: Septic polyarthritis is rarer than septic monoarthritis, but associated with higher mortality. Septic polyarthritis may be difficult to distinguish clinically from noninfectious inflammatory arthritis. We describe one of the largest samples of septic polyarthritis with the aim of distinguishing septic monoarthritis from polyarthritis. METHODS: We conducted a retrospective study of adults admitted to tertiary care with septic monoarthritis and polyarthritis...
September 13, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28917067/dengue-fever-clinical-features-of-567-consecutive-patients-admitted-to-a-tertiary-care-center-in-saudi-arabia
#11
Samar Badreddine, Fahmi Al-Dhaheri, Ammar Al-Dabbagh, Abdulrahman Al-Amoudi, Maged Al-Ammari, Nader Elatassi, Haytham Abbas, Rami Magliah, Abdulbasit Malibari, Hani Almoallim
To delineate the clinical features and outcomes of dengue infection and to guide clinician of early diagnosis and identification of risks factors for dengue hemorrhagic fever. Methods: This study is a retrospective cross-sectional. Clinical records of 567 patients with a confirmed diagnosis of dengue infection, admitted to a single hospital in Jeddah, Saudi Arabia, between January 2010 and  June 2014 were reviewed.  Results: Dengue infection was most common in adult males. Sixty-eight percent of infections were in Saudi nationals...
October 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28912038/proton-pump-inhibitor-use-is-associated-with-a-reduced-risk-of-infection-with-intestinal-protozoa
#12
Johnathan M Sheele
OBJECTIVE: Proton pump inhibitors (PPIs) can kill some human protozoan parasites in cell culture better than the drug metronidazole. Clinical data showing an antiprotozoal effect for PPIs are lacking. The objective of the study is to determine if PPI use is associated with a reduced risk of having intestinal parasites. METHODS: We obtained electronic medical record data for all persons who received a stool ova and parasite (O & P) examination at our tertiary care academic medical center in Cleveland, Ohio, between January 2000 and September 2014...
September 11, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28911852/molecular-epidemiology-and-the-resistance-and-virulence-properties-of-pseudomonas-aeruginosa-cross-colonization-clonal-isolates-in-the-non-outbreak-setting
#13
Pengwei Hu, Jiayi Chen, Yuhang Chen, Tao Zhou, Xin Xu, Xiaofang Pei
The molecular epidemiology of Pseudomonas aeruginosa cross-colonization isolates has received limited attention in the non-outbreak setting. Also the roles of P. aeruginosa resistance and virulence in cross-colonization need to be further studied. This study aims to launch a tracking investigation to determine the epidemiological relationship of P. aeruginosa clinical and environmental isolates, identify the cross-colonization routes, and characterize the resistance and virulence properties of clonal clusters and sporadic strains in the respiratory care wards of a tertiary care hospital...
September 11, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28910381/genetic-characterization-of-blandm-harboring-plasmids-in-carbapenem-resistant-escherichia-coli-from-myanmar
#14
Yo Sugawara, Yukihiro Akeda, Noriko Sakamoto, Dan Takeuchi, Daisuke Motooka, Shota Nakamura, Hideharu Hagiya, Norihisa Yamamoto, Isao Nishi, Hisao Yoshida, Kazuhisa Okada, Khwar Nyo Zin, Mya Mya Aye, Kazunori Tonomo, Shigeyuki Hamada
The bacterial enzyme New Delhi metallo-β-lactamase hydrolyzes almost all β-lactam antibiotics, including carbapenems, which are drugs of last resort for severe bacterial infections. The spread of carbapenem-resistant Enterobacteriaceae that carry the New Delhi metallo-β-lactamase gene, blaNDM, poses a serious threat to public health. In this study, we genetically characterized eight carbapenem-resistant Escherichia coli isolates from a tertiary care hospital in Yangon, Myanmar. The eight isolates belonged to five multilocus-sequence types and harbored multiple antimicrobial-resistance genes, resulting in resistance against nearly all of the antimicrobial agents tested, except colistin and fosfomycin...
2017: PloS One
https://www.readbyqxmd.com/read/28904920/antimicrobial-susceptibility-pattern-of-extended-spectrum-beta-lactamases-producing-organisms-isolated-in-a-tertiary-care-hospital-bangladesh
#15
Mohammad Jobayer, Zeenat Afroz, Sultana Shazeda Nahar, Ayesha Begum, Shahin Ara Begum, S M Shamsuzzaman
CONTEXT: Infection caused by extended-spectrum beta-lactamases (ESBL) producing organism is a major problem regarding antibiotic resistance. AIMS: The aim of this study was to find out the antibiogram of ESBL producing organisms isolated from various samples. SETTINGS AND DESIGN: This cross-sectional study was carried out in the Department of Microbiology of a Tertiary Care Hospital, Dhaka, Bangladesh from January to June 2014. SUBJECTS AND METHODS: One Hundred and seventy-nine ESBL producing Gram-negative organisms detected phenotypically by double-disc synergy test were enrolled in this study...
July 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28904915/microbiological-surveillance-of-operation-theatres-five-year-retrospective-analysis-from-a-tertiary-care-hospital-in-north-india
#16
Dipender Kaur Najotra, Aneeta Singh Malhotra, Poonam Slathia, Shivani Raina, Ashok Dhar
INTRODUCTION: Microbiological contamination of air and environment in the operation theaters (OTs) are major risk factor for surgical site and other hospital-associated infections. OBJECTIVES: The aim was to identify bacterial colonization of surfaces and equipment and to determine the microbial contamination of air in the OTs of a tertiary care hospital. MATERIALS AND METHODS: Five years (January 2010-December 2014) retrospective analysis of the data obtained from routine microbiological surveillance of the five OTs of the hospital was done...
July 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28904744/clinical-and-surgical-characteristics-of-infected-diabetic-foot-ulcers-in-a-tertiary-hospital-of-mexico
#17
Estrella Cervantes-García, Paz María Salazar-Schettino
Background: The objective of this study was to determine the clinical and surgical characteristics of diabetic foot ulcers in a tertiary level hospital in Mexico. Methods: We performed a longitudinal, descriptive study from July, 2012 to August, 2015 on a sample composed of 100 patients with type 2 diabetes mellitus and infected diabetic foot ulcers. We analyzed socio-demographic variables, comorbidities, characteristics of ulcers, and the applied treatment. Results: We found that the most affected areas were the forefoot (48%) and the plantar region (55%) of the foot...
2017: Diabetic Foot & Ankle
https://www.readbyqxmd.com/read/28904483/fecal-carriage-of-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-in-intensive-care-unit-patients
#18
Shalini Shenoy Mulki, Kavya Ramamurthy, Sevitha Bhat
BACKGROUND AND AIMS: Increasing and indiscriminate use of antibiotics has led the bacteria to develop resistance to most of the antibiotics. Beta-lactamase production is the mechanism of resistance to beta-lactams. Extended-spectrum beta-lactamases (ESBLs) have been found in the members of Enterobacteriaceae such as Escherichia coli and Klebsiella spp. which are the common health-care-associated pathogens. The aim was to study the rate of fecal carriage of ESBL-producing Enterobacteriaceae in patients admitted to the Intensive Care Unit (ICU) of tertiary care hospital and follow them subsequently for the development of infections...
August 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28904433/risk-factors-for-urinary-tract-infections-in-renal-allograft-recipients-experience-of-a-tertiary-care-center-in-hyderabad-south-india
#19
M V N L R Mohan, M Neeraja, S Sudhaharan, S B Raju, T Gangadhar, V Lakshmi
Renal transplantation is an effective and commonly performed procedure for end-stage renal disease. Urinary tract infections are a major cause of morbidity and mortality in renal transplant patients. As data on postrenal transplant urinary tract infections from the Indian subcontinent are limited, the present study was conducted to estimate the burden of urinary tract infections in this vulnerable group of patients. This was a prospective study on patients undergoing renal transplantation in 2014 at our tertiary hospital in South India with a follow-up of 2 years to evaluate the risk factors for urinary tract infections...
September 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28902923/molecular-microbiological-and-clinical-characterization-of-clostridium-difficile-isolates-from-tertiary-care-hospitals-in-colombia
#20
Clara Lina Salazar, Catalina Reyes, Santiago Atehortua, Patricia Sierra, Margarita María Correa, Daniel Paredes-Sabja, Emma Best, Warren N Fawley, Mark Wilcox, Ángel González
In Colombia, the epidemiology and circulating genotypes of Clostridium difficile have not yet been described. Therefore, we molecularly characterized clinical isolates of C.difficile from patients with suspicion of C.difficile infection (CDI) in three tertiary care hospitals. C.difficile was isolated from stool samples by culture, the presence of A/B toxins were detected by enzyme immunoassay, cytotoxicity was tested by cell culture and the antimicrobial susceptibility determined. After DNA extraction, tcdA, tcdB and binary toxin (CDTa/CDTb) genes were detected by PCR, and PCR-ribotyping performed...
2017: PloS One
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