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https://www.readbyqxmd.com/read/29044013/-acute-aortic-regurgitation-due-to-infective-endocarditis
#1
Claudia M Cortés, José H Casabé, Roberto R Favaloro, Héctor Raffaelli, Eduardo Dulbecco, José Abud, Fabián Salmo, Melina Riesco, Milagros Seijo, Eduardo Guevara
Acute aortic regurgitation (AAR) due to infective endocarditis (IE) is a serious disease and usually requires surgical treatment. Our study aims to compare the clinical, echocardiographic, and microbiological characteristics as well as in-hospital outcome of patients with AAR according to the severity of heart failure (HF) and to evaluate predictors of in-hospital mortality in a tertiary centre. In a prospective analysis, we compared patients with NYHA functional class I-II HF (G1) vs. functional class III-IV HF (G2)...
2017: Medicina
https://www.readbyqxmd.com/read/29042916/the-proposal-of-paediatric-virology-and-its-perspectives-an-interview-with-professor-of-paediatrics-maria-theodoridou
#2
Ioannis N Mammas, Demetrios A Spandidos
Professor Maria Theodoridou, Emeritus Professor of Paediatrics at the University of Athens, is one of the few paediatricians in Greece, who have experienced almost all the infectious diseases of the second half of the 20th century and their severe consequences, prior to the widespread adoption of immunisations. A milestone during her career was the establishment of a specialised National Reference Unit for the care of paediatric patients with acquired immune deficiency syndrome (AIDS) at the 'Aghia Sophia' Children's Hospital in Athens, Greece...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042067/malignant-external-otitis-the-shifting-treatment-paradigm
#3
Daniel A Carlton, Enrique E Perez, Eric E Smouha
IMPORTANCE: Malignant external otitis (MEO) is an aggressive infection occurring in immunocompromised hosts. Increasing antimicrobial resistance is making the disease more difficult to treat. OBJECTIVE: Determine if there has been a shift in the microbiology and outcomes of MEO. DESIGN: A retrospective case series at a tertiary care institution. SETTING: Inpatient and outpatient tertiary care hospital. PARTICIPANTS: 12 cases of recent MEO were reviewed...
May 25, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29035701/does-sofa-predict-outcomes-better-than-sirs-in-brazilian-icu-patients-with-suspected-infection-a-retrospective-cohort-study
#4
Regis Goulart Rosa, Rafael Barberena Moraes, Thiago Costa Lisboa, Daniel Pretto Schunemann, Cassiano Teixeira
We compared the discriminatory capacity of the sequential organ failure assessment (SOFA) versus the systemic inflammatory response syndrome (SIRS) score for predicting ICU mortality, need for and length of mechanical ventilation (MV), ICU stay, and hospitalization in patients with suspected infection admitted to a mixed Brazilian ICU. We performed a retrospective analysis of a longitudinal ICU database from a tertiary hospital in Southern Brazil. Patients were categorized according to whether they met the criteria for sepsis according to SOFA (variation ≥2 points over the baseline clinical condition) and SIRS (SIRS score ≥2 points)...
October 13, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29033719/epidemiology-and-characteristics-of-nosocomial-infections-in-critically-ill-patients-in-a-tertiary-care-intensive-care-unit-of-northern-india
#5
Anirban Hom Choudhuri, Mitali Chakravarty, Rajeev Uppal
BACKGROUND AND AIMS: The prevalence of nosocomial infection is higher in the Intensive Care Unit (ICU) than other areas of the hospital. The present observational study was undertaken to describe the epidemiology and characteristics of nosocomial infections acquired in a tertiary care ICU and the impact of the various risk factors in their causation. MATERIALS AND METHODS: A retrospective study was conducted on the prospectively collected data of 153 consecutive patients admitted in a tertiary care ICU between July 2014 and December 2015...
October 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29033270/a-survey-of-contact-lens-related-complications-in-a-tertiary-hospital-in-china
#6
Weiwei Li, Xuguang Sun, Zhiqun Wang, Yang Zhang
PURPOSE: To describe the type of complications related to contact lens (CL) wear in a tertiary hospital in XX, China. METHODS: A retrospective study of 141 patients who complained discomfort after wearing contact lens on an outpatient basis of XX Hospital were conducted from the January 2012 to December 2015. The data included patients' demographics, lens type, history, slit-lamp examination, reports of corneal scrapings, culture, and examination of in vivo confocal microscopy...
October 12, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29033034/antimicrobial-resistance-among-children-in-sub-saharan-africa
#7
REVIEW
Phoebe C M Williams, David Isaacs, James A Berkley
Antimicrobial resistance is an important threat to international health. Therapeutic guidelines for empirical treatment of common life-threatening infections depend on available information regarding microbial aetiology and antimicrobial susceptibility, but sub-Saharan Africa lacks diagnostic capacity and antimicrobial resistance surveillance. We systematically reviewed studies of antimicrobial resistance among children in sub-Saharan Africa since 2005. 18 of 1075 articles reviewed met inclusion criteria, providing data from 67 451 invasive bacterial isolates from inconsistently defined populations in predominantly urban tertiary settings...
October 9, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29032055/microbiological-characterization-of-klebsiella-pneumoniae-isolates-causing-bloodstream-infection-from-five-tertiary-hospitals-in-beijing-china
#8
Yanning Ma, Chunmei Bao, Jie Liu, Xiuhong Hao, Jingui Cao, Liyan Ye, Jiyong Yang
BACKGROUND: Klebsiella pneumoniae exhibits prevalence in China. Little is known about the microbiological characterization of clinical K. pneumoniae isolates causing bloodstream infections (BSIs). METHODS: BSI-causing K. pneumoniae (BSIKpn) isolates were collected from five tertiary-care hospitals in Beijing, China. Their genetic relatedness was analyzed by pulsed-field gel electrophoresis (PFGE), antimicrobial susceptibility was determined by agar dilution method, and sequence type (ST) was evaluated by multilocus sequence typing (MLST)...
October 11, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29031864/bloodstream-infections-following-different-types-of-surgery-in-a-finnish-tertiary-care-hospital-2009-2014
#9
Kirsi Skogberg, Keiju S K Kontula, Asko Järvinen, Outi Lyytikäinen
We evaluated the risk and outcome of bloodstream infections (BSIs) following surgery. BSIs were identified in Helsinki University Hospital during 2009-2014 as part of the national surveillance. Of 711 BSIs identified, 51% were secondary and 49% primary. The rate was highest after cardiovascular surgery (8.7/1000 procedures) and lowest after gynaecologic (1.0/1000). Surgical site infection was the most common source of secondary BSIs (34%) and 45% of primary BSIs were central line-associated. The 28-day case fatality ranged from 0% in gynaecology/obstetrics to 21% in cardiovascular surgery...
October 12, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29030859/outpatient-parenteral-antimicrobial-therapy-in-enterococcus-faecalis-infective-endocarditis
#10
M V Gil-Navarro, L E Lopez-Cortes, R Luque-Marquez, J Galvez-Acebal, A de Alarcon-Gonzalez
WHAT IS KNOWN AND OBJECTIVE: Enterococcus faecalis is the third most common causal agent of infective endocarditis. Currently, the treatment recommended is a combination of ampicillin (2 g/4 h) plus ceftriaxone (2 g/12 h), so patients must remain hospitalized for almost 6 weeks to receive the treatment. They are not generally included in outpatient parenteral antimicrobial therapy programs because 2 different electronic pumps are required to administer these 2 antibiotics. To enable the treatment of patients with E...
October 13, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29029367/genetic-diversity-of-plasmodium-falciparum-merozoite-surface-protein-1-block-2-glutamate-rich-protein-and-sexual-stage-antigen-pfs25-from-chandigarh-north-india
#11
Hargobinder Kaur, Rakesh Sehgal, Kapil Goyal, Nikita Makkar, Richa Yadav, Praveen K Bharti, Neeru Singh, Nilanju P Sarmah, Pradymna K Mohapatra, Jagadish Mahanta, Devendra Bansal, Ali A Sultan, Jagat R Kanwar
OBJECTIVE: To elucidate the genetic diversity of P. falciparum in residual transmission foci of northern India. METHODS: Clinically suspected malaria patients were screened for malaria infection by microscopy. 48 P. falciparum-infected patients were enrolled from two tertiary care hospitals in Chandigarh, India. Blood samples were collected from enrolled patients, genomic DNA extraction and nested PCR was performed for further species confirmation. Sanger sequencing was carried out using block 2 region of msp1, R2 region of glurp and pfs25 specific primers...
October 13, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29026536/implementation-of-central-line-associated-bloodstream-infection-prevention-bundles-in-a-surgical-intensive-care-unit-using-peer-tutoring
#12
Sang-Won Park, Suhui Ko, Hye-Sun An, Ji Hwan Bang, Woo-Young Chung
BACKGROUND: Central line-associated bloodstream infections (CLABSIs) can be prevented through well-coordinated, multifaceted programs. However, implementation of CLABSI prevention programs requires individualized strategies for different institutional situations, and the best strategy in resource-limited settings is uncertain. Peer tutoring may be an efficient and effective method that is applicable in such settings. METHODS: A prospective intervention was performed to reduce CLABSIs in a surgical intensive care unit (SICU) at a tertiary hospital...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29026473/hepatitis-c-genotypes-in-libya-correlation-with-patients-characteristics-level-of-viremia-and-degree-of-liver-fibrosis
#13
Abdel-Naser Elzuoki, Islam Elzouki, Sabah Albarassi, Mohamed Gammo, Abdalla Burwaiss
OBJECTIVES: Our study sought to determine the distribution of hepatitis C virus (HCV)-genotypes among patients attending two tertiary care hospitals in Benghazi and Tripoli, Libya, and correlate this with patient's characteristics, viral load, and degree of fibrosis. METHODS: We conducted a retrospective study of 286 HCV-RNA positive Libyan patients referred from different health care facilities in east and west Libya for specific HCV treatment. HCV genotyping was carried out by gene amplification...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29024067/evaluation-of-multiplex-real-time-pcr-for-identifying-dermatophytes-in-clinical-samples-a-multicentre-study
#14
Shany Sherman, Maya Goshen, Orit Treigerman, Keren Ben-Zion, Marie-Jeanne Carp, Noam Maisler, Inbal Binsky Ehrenreich, Aviva Kimchi, Sara Lifshitz, Gill Smollan, Batya Davidovici, Michael David, Emmilia Hodak, Rina Segal
BACKGROUND: The gold-standard method for dermatophyte identification involves direct microscopy and culture, which have inherent shortcomings. Only few molecular methods have been standardised for routine clinical work. OBJECTIVES: To develop and test a platform for identifying the most common dermatophytes in Israel using multiplex real-time polymerase chain reaction (RT-PCR). METHODS: Specific primers were designed for the multiplex system (LightCycler 480) according to known cultures and validated by reference isolates...
October 12, 2017: Mycoses
https://www.readbyqxmd.com/read/29022552/multiplex-pcr-for-identification-of-six-clinically-relevant-streptococci
#15
Rujirat Hatrongjit, Yukihiro Akeda, Shigeyuki Hamada, Marcelo Gottschalk, Anusak Kerdsin
PURPOSE: The aim of this study was to develop a multiplex PCR (mPCR) for simultaneous detection (single reaction) of six clinically relevant streptococcal species: Streptococcus pneumoniae, Streptococcus suis, Streptococcus gallolyticus subsp. gallolyticus, S. gallolyticus subsp. pasteurianus, Streptococcus intermedius and Streptococcus anginosus/constellatus. METHODS: mPCR with primers specific for S. pneumoniae (lytA), S. suis (recN), S. gallolyticus subsp. gallolyticus (tanB), S...
October 12, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29021723/bacterial-infections-in-burn-wound-patients-at-a-tertiary-teaching-hospital-in-accra-ghana
#16
O A Forson, E Ayanka, M Olu-Taiwo, P J Pappoe-Ashong, P J Ayeh-Kumi
Intact human skin surface is essential for protection against infection, preservation of body fluid homeostasis and thermoregulation. Burn injury compromises the skin barrier and enables bacterial infection, hence delaying burn wound healing. This study aimed to determine the microbial profile of burn wounds, and resistance patterns of microbes with respect to the source of the injured patient's wound. Fifty wound swab samples were collected from fifty burn patients at the Korle-Bu Teaching Hospital, Accra (KBTH)...
June 30, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/29020940/the-epidemiology-and-transmission-of-methicillin-resistant-staphylococcus-aureus-in-the-community-in-singapore-study-protocol-for-a-longitudinal-household-study
#17
Nivedita Shankar, Angela Li Ping Chow, Jolene Oon, Li Yang Hsu, Brenda Ang, Junxiong Pang, Paola Florez De Sessions, Balamurugan Periaswamy, Paul A Tambyah, Desmond B Teo, Clarence C Tam
BACKGROUND/AIM: Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common multidrug-resistant organisms in healthcare settings worldwide, but little is known about MRSA transmission outside of acute healthcare settings especially in Asia. We describe the methods for a prospective longitudinal study of MRSA prevalence and transmission. METHODS: MRSA-colonized individuals were identified from MRSA admission screening at two tertiary hospitals and recruited together with their household contacts...
October 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29020834/high-transverse-skin-incisions-may-reduce-wound-complications-in-obese-women-having-cesarean-sections-a-pilot-study
#18
Robert Walton, Kelsey Shnaekel, Songthip Ounpraseuth, Peter Napolitano, Everett Magann
OBJECTIVE: Women having cesarean section have a high risk of wound complications. Our objective was to determine whether high transverse skin incisions are associated with a reduced risk of cesarean wound complications in women with BMI greater than 40. METHODS: A retrospective cohort study was undertaken of parturients ages 18-45 with BMI greater than 40 having high transverse skin incisions from January 2010 to April 2015 at a tertiary maternity hospital. Temporally matched controls had low transverse skin incisions along with a BMI greater than 40...
October 11, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29020166/long-term-impact-of-an-educational-antimicrobial-stewardship-program-on-hospital-acquired-candidemia-and-multidrug-resistant-bloodstream-infections-a-quasi-experimental-study-of-interrupted-time-series-analysis
#19
José Molina, Germán Peñalva, María V Gil-Navarro, Julia Praena, José A Lepe, María A Pérez-Moreno, Carmen Ferrándiz, Teresa Aldabó, Manuela Aguilar, Peter Olbrich, Manuel E Jiménez-Mejías, María L Gascón, Rosario Amaya-Villar, Olaf Neth, María J Rodríguez-Hernández, Antonio Gutiérrez-Pizarraya, José Garnacho-Montero, Cristina Montero, Josefina Cano, Julián Palomino, Raquel Valencia, Rocío Álvarez, Elisa Cordero, Marta Herrero, José M Cisneros
Background: The global crisis of bacterial resistance urges the scientific community to implement intervention programs in healthcare facilities to promote an appropriate use of antibiotics. However, the clinical benefits or the impact on resistance of these interventions has not been definitively proven. Methods: We designed a quasi-experimental intervention study with an interrupted time-series analysis. A multidisciplinary team conducted a multifaceted educational intervention in our tertiary-care hospital over a five-year period...
August 7, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28990241/clinically-indicated-replacement-versus-routine-replacement-of-peripheral-venous-catheters-in-adults-a-nonblinded-cluster-randomized-trial-in-china
#20
Lichun Xu, Yan Hu, Xiaojin Huang, Jianguo Fu, Jinhui Zhang
AIM: The purpose of this study was to investigate the safety of clinically indicated peripheral intravenous catheters (PIVC) replacement intervals. BACKGROUND: Peripheral intravenous catheters are used internationally, including in China where PIVCs are routinely replaced every 72 to 96 hours. Despite some recent international evidence showing such routine replacement is unnecessary, developing countries such as China have no supporting data. METHOD: This cluster-randomized trial was conducted between December 2 and December 31, 2013, in 10 internal medicine wards and 10 surgery wards at a tertiary referral teaching hospital in Xiamen, China...
October 9, 2017: International Journal of Nursing Practice
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