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Functional Defecits

Mohammad Haddadi, Samaneh Reiszadeh Jahromi, Upendra Nongthomba, T Shivanandappa, S R Ramesh
Oxidative stress is one of the major etiological factors implicated in pathogenesis of neurodegenerative diseases. Since neurons are more sensitive to oxidative damage there is an increasing interest in developing novel antioxidant therapies, especially herbal preparations due to their safety profile and high efficiency. In this regard, the neuroprotective potential of a novel antioxidant compound, 4-hydroxyisophthalic acid (4-HIPA) isolated from aqueous extract of Decalepis hamiltonii roots was examined using transgenic Drosophila model of taupathy expressing wild-type and mutant forms of 2N4R isoform of human microtubule associated protein tau (MAPT)...
November 2016: Neurochemistry International
Giovanni Taveggia, Alberto Borboni, Lorena Salvi, Chiara Mulé, Stefania Fogliaresi, Jorge H Villafañe, Roberto Casale
BACKGROUND: A prompt and effective physical and rehabilitation medicine approach is essential to obtain recovery of an impaired limb to prevent tendon shortening, spasticity and pain. Robot-assisted virtual reality intervention has been shown to be more effective than conventional interventions and achieved greater improvement in upper limb function. AIM: The aim of this study was to evaluate the effectiveness of robotic-assisted motion and activity in addition to PRM for the rehabilitation of the upper limb in post-stroke inpatients...
December 2016: European Journal of Physical and Rehabilitation Medicine
Chang Soon Choi, Minha Hong, Ki Chan Kim, Ji-Woon Kim, Sung Min Yang, Hana Seung, Mee Jung Ko, Dong-Hee Choi, Jueng Soo You, Chan Young Shin, Geon Ho Bahn
A substantial proportion of patients with autism spectrum disorder (ASD) display hyperactivity as a comorbid symptom. Exposure to valproic acid (VPA) during pregnancy produces ASD-like core behavioral phenotypes as well as hyperactivity in offspring both in human and experimental animals, which makes it a plausible model to study ASD-related neurobiological processes. In this study, we examined the effects of two of currently available attention defecit hyperactivity disorder (ADHD) medications, methylphenidate (MPH) and atomoxetine (ATX) targeting dopamine and norepinephrine transporters (DAT and NET), respectively, on hyperactive behavior of prenatally VPA-exposed rat offspring...
September 2014: Biomolecules & Therapeutics
P V Cherniavs'kyĭ, Z M Datsenko, L H Moiseieva, N V Kanivets', O P Kozulina, A M Boroda, O S Abakumova
It has been established that a deficit of essential fatty acids (EFA) in the animal organism induces specific modifications of composition of fatty acid (FA) of general phospholipids and plasmalogenic P1 in microsomal tissue membranes with various functions and affects the activity of phospholipase A2. It has been shown that arachidonic (AA), docosapentaenoic (DPA) and docosahexaenoic (DHA) acids in the composition of general phospholipids - phosphatidylcholine (PC), phosphatidylethanolamine (PEA) and plasmalogens PC and PEA react to EFA deficit in the organism...
September 2006: Ukraïnsʹkyĭ Biokhimichnyĭ Z︠h︡urnal
W D Snider, I Silos-Santiago
Neurotrophins are the most profound known regulators of survival in the developing peripheral nervous system. Within dorsal root ganglia, the signalling receptors for the different members of the neurotrophin family are distributed in distinct patterns suggesting regulation of different functional classes of sensory neurons. Abnormalities observed in neurotrophin receptor mutant mice have confirmed this idea. Both trkA (-/-) and trkC (-/-) mice have striking neurological defecits referrable to subpopulations of DRG neurons which have distinct axon projections in the periphery...
March 29, 1996: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
V S Paukov, N K Khitrov, V A Frolov, A I Svistukhin
It was experimentally established that the destruction of mitochondria due to a reduction of ATP production and to their compensatory hyperfunction under energy defecit is underlying some disorders in the myocardial metabolism caused by 2,4-DNP intoxication. Energy deficit results in K+ metabolism disorders and the related acetylcholine synthesis which predisopses the changes in the cardiac function and still further increases the myocardial requirements of energy. The bio-energy disorders develop in a vicious circle manner, and when the intoxication increases, it inevitably results in energy depletion and cardiac arrest...
November 1976: Kardiologiia
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