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JOURNAL ARTICLE
Sophie Brunner-Ziegler, Bernd Jilma, Gabriele Grimm, Petra Jilma-Stohlawetz
BACKGROUND: In newborns, elevated nucleated red blood cell (NRBC) levels can be associated with enhanced erythropoietic stress and might be predictive for adverse outcome. Also, the presence of NRBC in peripheral blood might lead to erroneous enumeration results of white blood cells in automated hematology analyzers. We aimed to assess the comparability of the Sysmex XN 1000 to manual slide reviews and correlation of NRBC with inflammation markers. METHODS: Specimens of 3397 children under 1 year were compared by automated and microscopic NRBC enumeration...
April 15, 2024: Journal of Clinical Laboratory Analysis
#2
Bryce R Christensen, Chung-Ting J Kou, Lauren E Lee
We present a rare case of hemophagocytic lymphohistiocytosis (HLH) secondary to nasal-type extranodal natural killer/T-cell lymphoma (ENKL). Nasal-type ENKL is a rare subtype of non-Hodgkin's lymphoma usually associated with Epstein-Barr virus (EBV). The patient was a 19-year-old woman who presented with facial numbness, diminished hearing, and dysgeusia. She was febrile with palatal necrosis, loss of gag reflex, and cranial nerve palsies. Labs revealed neutropenia. Broad-spectrum antimicrobials, including amphotericin, were started...
March 2024: Curēus
#3
JOURNAL ARTICLE
Farooq A Wani, Ashokkumar Thirunavukkarasu, Hatim Alrashed, Abdalrhman S Alblwan, Yazeed M Alfuhigi, Mohammed Dilli, Layth Alruwaili
BACKGROUND: The prevalence of hypothyroidism is high in Saudi Arabia and the contributing factors are iodine deficiency and lack of balanced nutrition. This study aims to correlate the gender, age, and presence of co-morbidities with the laboratory findings and clinical presentation. METHODOLOGY: A cross-sectional study was done in the hospitals of the Al-Jouf region. The files of the patients diagnosed with hypothyroidism from the last two years were retrieved by non-probability consecutive sampling technique...
March 2024: Curēus
#4
Pilar Musalem, Cristian Pedreros-Rosales, Hans Müller-Ortiz, Carlos Gutierrez-Navarro, J Daniel Carpio
Complement-mediated thrombotic microangiopathy (CM-TMA) is a rare and life-threatening complication that can occur in kidney transplant recipients, with various potential triggers including immunosuppressive medications. The optimal management and duration of treatment with C5 inhibitors (C5i) for CM-TMA in this patient population remain areas of ongoing investigation. We present the case of a 38-year-old female with a history of IgA nephropathy who underwent preemptive living-related kidney transplantation and subsequently developed CM-TMA seven years post-transplant...
April 14, 2024: Nephron
#5
JOURNAL ARTICLE
Patrícia Oliveira Cunha Terra, Gil Cunha De Santis, Benedito de Pina Almeida Prado Júnior, Luciana Correa Oliveira
INTRODUCTION: Immune thrombotic thrombocytopenic purpura (iTTP) is characterized by acute systemic microvascular thrombosis and is associated with a high morbidity and mortality, especially in delayed diagnosis (later than 6-7 days from symptoms). iTTP data in Brazil is scarce, so we aimed to characterize the clinical presentation and identify predictors of death risk in patients with this disease in Brazil. METHODS: In this single-center retrospective study the patients who underwent therapeutic plasma exchange (TPE) for presumptive or confirmed iTTP were evaluated regarding the epidemiological, clinical, laboratorial characteristics and management...
December 30, 2023: Hematology, Transfusion and Cell Therapy
#6
JOURNAL ARTICLE
Maria A Kostromina, Elena A Tukhovskaya, Elvira R Shaykhutdinova, Yuliya A Palikova, Viktor A Palikov, Gulsara A Slashcheva, Alina M Ismailova, Irina N Kravchenko, Igor A Dyachenko, Evgeniy A Zayats, Yuliya A Abramchik, Arkady N Murashev, Roman S Esipov
The development of novel anticoagulants requires a comprehensive investigational approach that is capable of characterizing different aspects of antithrombotic activity. The necessary experiments include both in vitro assays and studies on animal models. The required in vivo approaches include the assessment of pharmacokinetic and pharmacodynamic profiles and studies of hemorrhagic and antithrombotic effects. Comparison of anticoagulants with different mechanisms of action and administration types requires unification of the experiment scheme and its adaptation to existing laboratory conditions...
April 3, 2024: International Journal of Molecular Sciences
#7
JOURNAL ARTICLE
Fang Liu, Wei Li, Ming-Gang Zhang, Zhen-Mei Song, Xiao-di Wang, Xiu-Hong Wang, Shi-Yu Du
BACKGROUND: Repeated episodes of jaundice and pruritus are common in a group of autosomal recessive liver diseases known as benign recurrent intrahepatic cholestasis. Benign recurrent intrahepatic cholestasis (BRIC) is divided into two types, type 1 and type 2, and is caused by mutations in the ATP8B1 and ABCB11 genes. Here, we report a rare case of BRIC type 2 mutation. CASE PRESENTATION: A 45-year-old Chinese man had three frequent episodes of jaundice marked by extensive excoriation and severe pruritis, although he had no prior history of jaundice...
April 12, 2024: Alternative Therapies in Health and Medicine
#8
JOURNAL ARTICLE
Dustin J Strasburg, Rosalie M Sterner, Sildane Va, Eapen K Jacob, Margaret A DiGuardo
BACKGROUND: Standard flow cytometry protocols for CD34+ cell enumeration designed for fresh samples are not appropriate for cryopreserved products. Special protocols have been developed to remove the cryoprotectant by quickly washing a freshly thawed sample. Exposing cells to a large volume of hypotonic solution and subsequent washing process was hypothesized to cause lab-induced cell death. Moreover, standard gating strategies must be altered to avoid reporting falsely high viabilities...
April 12, 2024: Transfusion
#9
Amiya Ranjan Nayak, Pratyusha Gudapati, Ganesh Kumar Viswanathan, Jasmita Dass, Mukul Aggarwal
No abstract text is available yet for this article.
April 11, 2024: International Journal of Laboratory Hematology
#10
JOURNAL ARTICLE
L Y Wang, Q L Hu, M Chen, C Yang, B Han
Objective: To evaluate the efficacy and safety of eculizumab in the treatment of paroxysmal nocturnal hemoglobinuria (PNH) in China. Methods: Data from PNH patients who received at least 3 months of full-dose eculizumab and were followed for at least 3 months between December 2022 and July 2023 were retrospectively collected. We evaluated changes in clinical and laboratory parameters after 1, 2, 3, and 6 months of eculizumab treatment. The rates of breakthrough hemolysis (BTH), extravascular hemolysis (EVH), and the occurrence of adverse reactions were also monitored...
February 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
#11
JOURNAL ARTICLE
S H Yi, W J Xiong, X X Cao, C Y Sun, J Du, H H Wang, L Wang, T Niu, Z X Jiang, Y Q Wei, H Xue, H L Chu, L G Qiu, J Li
Objective: To conduct a nationwide physician survey to better understand clinicians' disease awareness, treatment patterns, and experience of Waldenström macroglobulinemia (WM) in China. Methods: This cross-sectional study was conducted from February 2022 to July 2022 by recruiting clinicians with WM treatment experience from hematology, hematology-oncology, and oncology departments throughout China. Quantitative surveys were designed based on the qualitative interviews. Results: The study included 415 clinicians from 219 hospitals spread across thirty-three cities and twenty-two provinces...
February 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
#12
JOURNAL ARTICLE
Hui Sheng, Xin He, Zhiqiang Chen, Kewei Huang, Jingjing Yang, Xiaoli Wei, Minjie Mao
BACKGROUND: Primary pulmonary lymphoepithelioma-like carcinoma (PPLELC) is a rare yet aggressive malignancy. This study aims to investigate a deep learning model based on hematological indices, referred to as haematological indices-based signature (HIBS), and propose multivariable predictive models for accurate prognosis prediction and assessment of therapeutic response to immunotherapy in PPLELC. METHODS: This retrospective study included 117 patients with PPLELC who received immunotherapy and were randomly divided into a training (n=82) and a validation (n=35) cohort...
March 29, 2024: Translational Lung Cancer Research
#13
JOURNAL ARTICLE
Fan Huang, Chuan Ming, Yuqian Jiang, Chenli Li, Cheng Tan
INTRODUCTION: To identify the differentially expressed genes of acute myeloid leukaemia (AML) and construct and verify a survival prognosis model combined with patient survival information. METHODS: The TARGET database was searched to identify differentially expressed peripheral blood genes in children with AML and healthy children. A gene set functional analysis and pathway analysis were performed using gene ontology and the KEGG pathway. A prognostic model for children with AML was constructed using univariate Cox, LASSO Cox regression and multivariate Cox regression analyses...
April 10, 2024: International Journal of Laboratory Hematology
#14
JOURNAL ARTICLE
Romy T Meier, Leendert Porcelijn, Suzanne Hofstede-van Egmond, Yvonne M C Henskens, Jonathan M Coutinho, Marieke J H A Kruip, An K Stroobants, Jaap J Zwaginga, Johanna G van der Bom, C Ellen van der Schoot, Masja de Haas, Rick Kapur
BACKGROUND AND OBJECTIVES: Vaccine-induced thrombotic thrombocytopenia (VITT) is a rare adverse effect characterized by thrombocytopenia and thrombosis occurring after COVID-19 vaccination. VITT pathophysiology is not fully unravelled but shows similarities to heparin-induced thrombocytopenia (HIT). HIT is characterized by the presence of antibodies against platelet factor 4 (PF4)/heparin complex, which can activate platelets in an FcγRIIa-dependent manner, whereas IgG-antibodies directed against PF4 play an important role in VITT...
April 10, 2024: Vox Sanguinis
#15
JOURNAL ARTICLE
Milanka Milosavić, Marko Lilić, Zorana Andrić
BACKROUND AND OBJECTIVES: Blood transfusion therapy is vital for many patient groups. They can cause many complications, and the development of anti-red blood cell (RBC) antibodies is of significant importance. Molecules of class II human leucocyte antigens (HLA) are one of the several factors that influence antibody development in patients. MATERIALS AND METHODS: In this study, we investigated 108 patients who developed antibodies against different erythrocyte antigens and 115 patients on multiple transfusion therapies who did not develop anti-RBC antibodies...
April 10, 2024: Vox Sanguinis
#16
JOURNAL ARTICLE
Johannes Lübke, Alicia Schmid, Deborah Christen, Hanneke N G Oude Elberink, Lambert F R Span, Marek Niedoszytko, Aleksandra Górska, Magdalena Lange, Karoline V Gleixner, Emir Hadzijusufovic, Alex Stefan, Irena Angelova-Fischer, Roberta Zanotti, Massimiliano Bonifacio, Patrizia Bonadonna, Khalid Shoumariyeh, Nikolas von Bubnoff, Sabine Müller, Cecelia Perkins, Chiara Elena, Luca Malcovati, Hans G Hagglund, Mattias Mattsson, Roberta Parente, Judit Varkonyi, Anna Belloni Fortina, Francesca Caroppo, Knut Brockow, Alexander Zink, Christine Breynaert, Toon Ieven, Akif Selim Yavuz, Michael Doubek, Vito Sabato, Tanja Schug, Karin Hartmann, Massimo Triggiani, Jason Gotlib, Olivier Hermine, Michel Arock, Hanneke C Kluin-Nelemans, Jens Peter Panse, Wolfgang R Sperr, Peter Valent, Andreas Reiter, Juliana Schwaab
Certain laboratory abnormalities correlate with subvariants of systemic mastocytosis (SM) and are often prognostically relevant. To assess the diagnostic and prognostic value of individual serum chemistry parameters in SM, 2607 patients enrolled within the European Competence Network on Mastocytosis (ECNM) and 575 patients enrolled within the German Registry on Eosinophils and Mast Cells (GREM) were analyzed. For screening and diagnosis of SM, tryptase was identified as the most specific serum parameter. For differentiation between indolent and advanced SM (AdvSM), the following serum parameters were most relevant: tryptase, alkaline phosphatase (AP), ß2-microglobulin, lactate dehydrogenase (LDH), albumin, vitamin B12, and C-reactive protein (P<0...
April 9, 2024: Blood Advances
#17
JOURNAL ARTICLE
Carl Dernell, John Astle, Abraham Bogachkov, Shelly Reimer, Anubha Wadhwa, Shadie S Majidi, Bethany Canales, Julie M Jorns
OBJECTIVES: To evaluate the utilization of hematopathology resources within our enterprise on axillary lymph node core biopsy (AxLNCB) specimens, particularly those obtained in the context of breast cancer screening. METHODS: The utilization of hematopathology resources was determined for all AxLNCB specimens over a 30-month period from across our enterprise, and chart review was performed for select patient demographics and radiographic features. The AxLNCB cases with benign histology were reviewed for subtyping of histologic patterns...
April 9, 2024: American Journal of Clinical Pathology
#18
JOURNAL ARTICLE
Abigail L Rich, Phillip Lin, Eric R Gamazon, Sandra S Zinkel
Cell death mediated by genetically defined signaling pathways influences the health and dynamics of all tissues, however the tissue specificity of cell death pathways and the relationships between these pathways and human disease are not well understood. We analyzed the expression profiles of an array of 44 cell death genes involved in apoptosis, necroptosis, and pyroptosis cell death pathways across 49 human tissues from GTEx, to elucidate the landscape of cell death gene expression across human tissues, and the relationship between tissue-specific genetically determined expression and the human phenome...
April 8, 2024: Cell Death & Disease
#19
JOURNAL ARTICLE
Lihuan Guan, Camilla S L Tuttle, Fedor Galkin, Alex Zhavoronkov, Andrea B Maier
BACKGROUND: Accelerated biological ageing is a major underlying mechanism of frailty development. This study aimed to investigate if the biological age measured by a blood biochemistry-based ageing clock is associated with frailty in geriatric rehabilitation inpatients. METHODS: Within the REStORing health of acutely unwell adulTs (RESORT) cohort, patients' biological age was measured by an ageing clock based on completed data of 30 routine blood test variables measured at rehabilitation admission...
April 6, 2024: Experimental Gerontology
#20
JOURNAL ARTICLE
Andrada S Chiron, Lucy Locher, Aurélie Sarthou, Aude Gleizes, Roman Krzysiek, Pascale Chretien, Salima Hacein-Bey-Abina
OBJECTIVES: Given that method validation is mandatory for compliance with the International Organization for Standardization (ISO) 15,189 standard requirements, we evaluated the analytical performance of the AQUIOS CL system (Beckman Coulter) and compared it with two bead-based flow cytometry (FCM) protocols (BD FACSCAntoTM- II and Beckman Coulter DxFLEX). There are no comparative literature data on standardized protocols for counting lymphocyte subsets on the new-generation cytometer DxFLEX...
April 8, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
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