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https://www.readbyqxmd.com/read/28329346/posttreatment-reactions-after-single-dose-diethylcarbamazine-or-ivermectin-in-subjects-with-loa-loa-infection
#1
Jesica A Herrick, Fanny Legrand, Raceline Gounoue, Godwin Nchinda, Céline Montavon, Jean Bopda, Steve Mbickmen Tchana, Bienvenu Etogo Ondigui, Konrad Nguluwe, Michael P Fay, Michelle Makiya, Simon Metenou, Thomas B Nutman, Joseph Kamgno, Amy D Klion
Background.: Severe adverse reactions have been observed in individuals with Loa loa infection treated with either diethylcarbamazine (DEC), the drug of choice for loiasis, or ivermectin (IVM), which is used in mass drug administration programs for control of onchocerciasis and lymphatic filariasis in Africa. In this study, posttreatment clinical and immunologic reactions were compared following single-dose therapy with DEC or IVM to assess whether these reactions have the same underlying pathophysiology...
March 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28322757/impaired-clinical-utility-of-sequential-patient-gem-blood-gas-measurements-associated-with-calibration-schedule
#2
George S Cembrowski, Qian Xu, Adam R Cembrowski, Junyi Mei, Hossein Sadrzadeh
BACKGROUND: Within- and/or between-instrument variation may falsely indicate patient trends or obscure real trends. We employ a methodology that transforms sequential intra-patient results into estimates of biologic and analytic variation. We previously derived realistic biologic variation (sb) of blood gas (BG) and hematology analytes. We extend this methodology to derive the imprecision of two GEM 4000 BG analyzers. METHODS: A laboratory data repository provided arterial BG, electrolyte and metabolite results generated by two GEM 4000s on ICU patients in 2012-2013...
March 18, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28322434/two-cases-of-alopecia-areata-treated-with-ruxolitinib-a%C3%A2-discussion-of-ideal-dosing-and-laboratory-monitoring
#3
Amy Vandiver, Nicholas Girardi, Jihad Alhariri, Luis A Garza
BACKGROUND: Alopecia areata is a relatively common condition affecting patients seen in community dermatology clinics. A 2014 study implicated the JAK1/JAK2 inhibitor, ruxolitinib in short-term treatment of alopecia, however little information exists about the long-term use in otherwise healthy individuals in the community setting. METHODS: A patient with chronic alopecia areata and a patient with acute onset alopecia universalis were treated with oral ruxolitinib for over a year...
March 21, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28318212/multiple-myeloma-diagnosis-and-treatment
#4
COMPARATIVE STUDY
Thomas C Michels, Keith E Petersen
Multiple myeloma accounts for 1.6% of all cancer cases and approximately 10% of hematologic malignancies in the United States. In 2015, an estimated 28,850 new cases of multiple myeloma were diagnosed in the United States, and the disease caused more than 11,000 deaths. Patients older than 65 years account for 85% of those diagnosed with multiple myeloma, and there is a twofold increased incidence in blacks compared with whites. Patients may present with bone pain or with symptoms that are often nonspecific, such as nausea, vomiting, malaise, weakness, recurrent infections, and weight loss...
March 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28304251/using-hematology-data-from-malaria-vaccine-research-trials-in-humans-and-rhesus-macaques-macaca-mulatta-to-guide-volume-limits-for-blood-withdrawal
#5
Sara R Hegge, Bradley W Hickey, Shannon M Mcgrath, V Ann Stewart
Guidelines on safe volume limits for blood collection from research participants in both humans and laboratory animals vary widely between institutions. The main adverse event that may be encountered in large blood volume withdrawal is iron-deficiency anemia. Monitoring various parameters in a standard blood panel may help to prevent this outcome. To this end, we analyzed the Hgb and MCV values from 43 humans and 46 macaques in malaria vaccine research trials. Although the percentage of blood volume removed was greater for macaques than humans, macaques demonstrated an overall increase of MCV over time, indicating the ability to respond appropriately to frequent volume withdrawals...
December 1, 2016: Comparative Medicine
https://www.readbyqxmd.com/read/28301316/a-new-approach-to-define-acceptance-limits-for-hematology-in-external-quality-assessment-schemes
#6
Mohamed Rida Soumali, Marjan Van Blerk, Abdelhadi Akharif, Stéphanie Albarède, Dagmar Kesseler, Gabriela Gutierrez, Barbara de la Salle, Inger Plum, Anne Guyard, Ana Paula Favia, Wim Coucke
BACKGROUND: A study performed in 2007 comparing the evaluation procedures used in European external quality assessment schemes (EQAS) for hemoglobin and leukocyte concentrations showed that acceptance criteria vary widely. For this reason, the Hematology working group from the European Organisation for External Quality Assurance Providers in Laboratory Medicine (EQALM) decided to perform a statistical study with the aim of establishing appropriate acceptance limits (AL) allowing harmonization between the evaluation procedures of European EQAS organizers...
March 16, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28300712/flow-liver-flow-a-retrospective-analysis-of-the-interplay-of-liver-disease-and-coagulopathy-in-chronic-subdural-hematoma
#7
John Paul George Kolcun, Joanna Elizabeth Gernsback, Angela Mae Richardson, Jonathan Russell Jagid
BACKGROUND: Chronic subdural hematoma (cSDH) is a common neurosurgical ailment, particularly in the elderly. A recent study uncovered an association between liver disease and recurrence in cSDH patients. Here, we explore that relationship to identify recurrence predictors in at-risk patients. OBJECTIVE: We hypothesized that the association between liver disease and recurrence was due to coagulopathy secondary to liver disease. METHODS: We retrospectively reviewed all cSDH patients treated with burr-hole drainage by two surgeons between 2007-2015...
March 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28300447/sweet-syndrome
#8
Jose Ricardo Casarin Costa, Anangelica Rodrigues Virgens, Luisa de Oliveira Mestre, Natasha Favoretto Dias, Luciana Paula Samorano, Neusa Yuriko Sakai Valente, Cyro Festa Neto
BACKGROUND: Sweet syndrome (SS) is an infrequent skin disease characterised by sudden onset of fever, leukocytosis, neutrophilia, and tender erythematous plaques infiltrated by neutrophils. Multiple conditions have been associated with this syndrome. OBJECTIVES: The aim of this study was to evaluate the clinical, epidemiological, laboratory, and histopathological findings and associations of patients with SS. METHODS: We conducted a retrospective study of 83 patients with SS followed between January 1, 2006, and January 31, 2015...
February 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28299211/epistaxis-as-a-common-presenting-symptom-of-glanzmann-s-thrombasthenia-a-rare-qualitative-platelet-disorder-illustrative-case-examples
#9
Michael Recht, Meera Chitlur, Derek Lam, Syana Sarnaik, Madhvi Rajpurkar, David L Cooper, Sriya Gunawardena
Children often present to emergency departments (EDs) with uncontrollable nose bleeding. Although usually due to benign etiologies, epistaxis may be the presenting symptom of an inherited bleeding disorder. Whereas most bleeding disorders are detected through standard hematologic assessments, diagnosing rare platelet function disorders may be challenging. Here we present two case reports and review diagnostic and management challenges of platelet function disorders with a focus on Glanzmann's thrombasthenia (GT)...
2017: Case Reports in Emergency Medicine
https://www.readbyqxmd.com/read/28297629/genomics-of-myeloproliferative-neoplasms
#10
Katerina Zoi, Nicholas C P Cross
Myeloproliferative neoplasms (MPNs) are a group of related clonal hematologic disorders characterized by excess accumulation of one or more myeloid cell lineages and a tendency to transform to acute myeloid leukemia. Deregulated JAK2 signaling has emerged as the central phenotypic driver of BCR -ABL1-negative MPNs and a unifying therapeutic target. In addition, MPNs show unexpected layers of genetic complexity, with multiple abnormalities associated with disease progression, interactions between inherited factors and phenotype driver mutations, and effects related to the order in which mutations are acquired...
March 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28296991/clinicopathologic-immunohistochemical-and-molecular-features-of-histiocytoid-sweet-syndrome
#11
Victoria Alegría-Landa, Socorro María Rodríguez-Pinilla, Angel Santos-Briz, José Luis Rodríguez-Peralto, Victor Alegre, Lorenzo Cerroni, Heinz Kutzner, Luis Requena
Importance: Histiocytoid Sweet syndrome is a rare histopathologic variant of Sweet syndrome. The nature of the histiocytoid infiltrate has generated considerable controversy in the literature. Objective: The main goal of this study was to conduct a comprehensive overview of the immunohistochemical phenotype of the infiltrate in histiocytoid Sweet syndrome. We also analyze whether this variant of Sweet syndrome is more frequently associated with hematologic malignancies than classic Sweet syndrome...
March 15, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28288851/clinically-distinct-presentations-of-copper-deficiency-myeloneuropathy-and-cytopenias-in-a-patient-using-excessive-zinc-containing-denture-adhesive
#12
Sahara J Cathcart, Alina G Sofronescu
OBJECTIVES: While copper deficiency has long been known to cause cytopenias, copper deficiency myeloneuropathy is a more recently described entity. Here, we present the case of two clinically distinct presentations of acquired copper deficiency syndromes secondary to excessive use of zinc-containing denture adhesive over five years: myeloneuropathy and severe macrocytic anemia and neutropenia. METHODS: Extensive laboratory testing and histologic evaluation of the liver and bone marrow, were necessary to rule out other disease processes and establish the diagnosis of copper deficiency...
March 10, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28286631/hemoglobin-willamette-%C3%AE-51pro-%C3%A2-arg-case-report-and-literature-review
#13
Orivaldo Alves Barbosa, Matheus Martins de Sousa Dias, Saymon Medeiros Távora, Gentil Claudino de Galiza Neto, Jacqueline Holanda de Souza, Herivaldo Ferreira da Silva
We report a case of hemoglobin (Hb) Willamette (β51 Pro → Arg) in the Hematology Department of a tertiary hospital in Fortaleza, Northeast of Brazil. A literature review of the cases described in health sciences databases using as a descriptor Hb Willamette was performed, revealing 12 reported cases, of which only one presented with anemia. Herein, we describe a case of a female 29 years old, with hemoglobinopathy Willamette presenting clinically with anemia, having the lowest hemoglobin rate of the published cases...
February 23, 2017: Hematology Reports
https://www.readbyqxmd.com/read/28285590/molecular-detection-of-hepatozoon-spp-and-cytauxzoon-sp-in-domestic-and-stray-cats-from-madrid-spain
#14
David Díaz-Regañón, Alejandra Villaescusa, Tania Ayllón, Fernando Rodríguez-Franco, Gad Baneth, Lydia Calleja-Bueno, Mercedes García-Sancho, Beatriz Agulla, Ángel Sainz
BACKGROUND: Different species of apicomplexan protozoans of the genera Hepatozoon and Cytauxzoon can infect domestic cats, but their epidemiology and clinical relevance are not fully understood. The aim of this study was to assess the molecular prevalence of Hepatozoon spp. and Cytauxzoon spp. and to identify associated risk factors and clinical and laboratory abnormalities in a population of cats from Madrid, Spain. METHODS: Six hundred and forty-four client-owned and stray cats from Madrid, Spain, were included in this study...
March 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28283960/neurological-and-neurosurgical-emergencies-in-patients-with-hematological-disorders
#15
REVIEW
Martha L Cruz, Shama Farooq, Fernando D Testai
PURPOSE OF REVIEW: Hematologic diseases are blood disorders which can affect different organs, including the central and peripheral nervous systems. Some of them are associated with increased risk of permanent disability and death. This review highlights a selected group of primary and acquired hematologic disorders that can present as neurologic or neurosurgical emergencies. RECENT FINDINGS: There is an increasing recognition of the broad neurologic presentations of hematologic disorders...
March 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28279156/premature-atherosclerosis-in-children-with-beta-thalassemia-major-new-diagnostic-marker
#16
Laila M Sherief, Osama Dawood, Adel Ali, Hanan S Sherbiny, Naglaa M Kamal, Mohamed Elshanshory, Osama Abd Alazez, Mohamed Abd Alhady, Mohamed Nour, Wesam A Mokhtar
BACKGROUND: Early vascular alteration, atherosclerosis and coronary artery disease have emerged as important cardiovascular complications among beta-thalassemia major (B-TM) patients. The aims of the current study were to assess the prevalence of premature atherosclerosis among our B-TM patients, and to investigate the diagnostic value of serum Osteoprotegerin assay as an early biomarker for atherosclerosis. METHODS: This cross-sectional study was conducted at Hematology unit - Pediatric Department, Zagazig University Children Hospital- Egypt in the period from March 2014 to March 2015...
March 9, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28274252/elevated-serum-autoantibodies-against-co-inhibitory-pd-1-facilitate-t-cell-proliferation-and-correlate-with-disease-activity-in-new-onset-systemic-lupus-erythematosus-patients
#17
Hui Shi, Junna Ye, Jialin Teng, Yufeng Yin, Qiongyi Hu, Xinyao Wu, Honglei Liu, Xiaobing Cheng, Yutong Su, Mengru Liu, Juanfang Gu, Ting Lu, HaoJie Chen, Hui Zheng, Yue Sun, Chengde Yang
BACKGROUND: Programmed cell death protein 1 (PD-1) plays an important role in immune response regulation as a co-inhibitory signal during T cell activation. However, there is little known about the serum autoantibody profile of PD-1 in systemic lupus erythematosus (SLE), a disease characterized by the breakdown of immune tolerance to self-antigens and an excessive production of autoantibodies. Thus, we aim to investigate the serum levels and function of anti-PD-1 in patients with new-onset SLE...
March 9, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28273010/post-babesiosis-warm-autoimmune-hemolytic-anemia
#18
Ann E Woolley, Mary W Montgomery, William J Savage, Maureen O Achebe, Kathleen Dunford, Sarah Villeda, James H Maguire, Francisco M Marty
Background Babesiosis, a tickborne zoonotic disease caused by intraerythrocytic protozoa of the genus babesia, is characterized by nonimmune hemolytic anemia that resolves with antimicrobial treatment and clearance of parasitemia. The development of warm-antibody autoimmune hemolytic anemia (also known as warm autoimmune hemolytic anemia [WAHA]) in patients with babesiosis has not previously been well described. Methods After the observation of sporadic cases of WAHA that occurred after treatment of patients for babesiosis, we conducted a retrospective cohort study of all the patients with babesiosis who were cared for at our center from January 2009 through June 2016...
March 9, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28270346/molecular-and-hematologic-relapses-in-adult-patients-with-acute-promyelocytic-leukemia-a-cohort-study
#19
Ilana de França Azevedo, Michelline Gomes Magalhães, Fernanda Ribeiro Souto, Washington Batista das Neves, Fárida Coeli de Barros Correia Melo, Eduardo Magalhães Rego, Raul Antônio Morais Melo
OBJECTIVE: To evaluate factors predictive for relapse in a cohort of adult patients with acute promyelocytic leukemia monitored by molecular methods during consolidation and during at least one month of maintenance therapy. METHODS: The charts and laboratory data of 65 adult patients with acute promyelocytic leukemia treated according to the International Consortium on Acute Promyelocytic Leukemia 2006 protocol were reviewed. The identification of the promyelocytic leukemia-retinoic acid receptor-alpha gene rearrangement at diagnosis, post-induction, post-consolidation and during maintenance treatment was performed by qualitative and quantitative reverse transcription polymerase chain reaction...
January 2017: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/28270345/clinical-and-laboratory-profile-of-patients-with-sickle-cell-anemia
#20
Phelipe Gabriel Dos Santos Sant'Ana, Ariane Moreira Araujo, Cynthia Teixeira Pimenta, Mário Lúcio Pacheco Ker Bezerra, Sílvio Pereira Borges Junior, Viviana Martins Neto, Janaina Sousa Dias, Aline de Freitas Lopes, Danyelle Romana Alves Rios, Melina de Barros Pinheiro
OBJECTIVE: This study aimed to describe and analyze clinical and laboratory characteristics of patients with sickle cell anemia treated at the Hemominas Foundation, in Divinópolis, Brazil. Furthermore, this study aimed to compare the clinical and laboratory outcomes of the group of patients treated with hydroxyurea with those patients that were not treated with hydroxyurea. METHODS: Clinical and laboratorial data were obtained by analyzing medical records of patients with sickle cell anemia...
January 2017: Revista Brasileira de Hematologia e Hemoterapia
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