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https://www.readbyqxmd.com/read/28727640/no-seasonal-changes-in-cognitive-functioning-among-high-school-football-athletes-implementation-of-a-novel-electrophysiological-measure-and-standard-clinical-measures
#1
Steven P Broglio, Richelle Williams, Ashley Rettmann, Brandon Moore, James T Eckner, Sean Meehan
OBJECTIVE: To evaluate neuroelectric and cognitive function relative to a season of football participation. Cognitive and neuroelectric function declines are hypothesized to be present in football athletes. DESIGN: Observational. SETTING: Athletic fields and research laboratory. PATIENTS (OR PARTICIPANTS): Seventy-seven high school athletes (15.9 + 0.9 years, 178.6 + 7.2 cm, 74.4 + 14.7 kg, and 0.8 + 0.8 self-reported concussions) participating in football (n = 46) and noncontact sports (n = 31)...
July 14, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28726733/interaction-of-mitochondria-with-the-endoplasmic-reticulum-and-plasma-membrane-in-calcium-homeostasis-lipid-trafficking-and-mitochondrial-structure
#2
REVIEW
Jędrzej Szymański, Justyna Janikiewicz, Bernadeta Michalska, Paulina Patalas-Krawczyk, Mariasole Perrone, Wiesław Ziółkowski, Jerzy Duszyński, Paolo Pinton, Agnieszka Dobrzyń, Mariusz R Więckowski
Studying organelles in isolation has been proven to be indispensable for deciphering the underlying mechanisms of molecular cell biology. However, observing organelles in intact cells with the use of microscopic techniques reveals a new set of different junctions and contact sites between them that contribute to the control and regulation of various cellular processes, such as calcium and lipid exchange or structural reorganization of the mitochondrial network. In recent years, many studies focused their attention on the structure and function of contacts between mitochondria and other organelles...
July 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28725482/systems-biology-driving-drug-development-from-design-to-the-clinical-testing-of-the-anti-erbb3-antibody-seribantumab-mm-121
#3
REVIEW
Birgit Schoeberl, Art Kudla, Kristina Masson, Ashish Kalra, Michael Curley, Gregory Finn, Emily Pace, Brian Harms, Jaeyeon Kim, Jeff Kearns, Aaron Fulgham, Olga Burenkova, Viara Grantcharova, Defne Yarar, Violette Paragas, Jonathan Fitzgerald, Marisa Wainszelbaum, Kip West, Sara Mathews, Rachel Nering, Bambang Adiwijaya, Gabriela Garcia, Bill Kubasek, Victor Moyo, Akos Czibere, Ulrik B Nielsen, Gavin MacBeath
The ErbB family of receptor tyrosine kinases comprises four members: epidermal growth factor receptor (EGFR/ErbB1), human EGFR 2 (HER2/ErbB2), ErbB3/HER3, and ErbB4/HER4. The first two members of this family, EGFR and HER2, have been implicated in tumorigenesis and cancer progression for several decades, and numerous drugs have now been approved that target these two proteins. Less attention, however, has been paid to the role of this family in mediating cancer cell survival and drug tolerance. To better understand the complex signal transduction network triggered by the ErbB receptor family, we built a computational model that quantitatively captures the dynamics of ErbB signaling...
2017: NPJ Systems Biology and Applications
https://www.readbyqxmd.com/read/28723994/structural-cooperation-the-fiocruz-experience
#4
José Roberto Ferreira, Luiz Eduardo Fonseca
This article examines the structural approach to health cooperation, focusing on its meaning as a method for promoting institutional policies to improve management models. We draw attention to the differences between this approach and the traditional disease-based approach, showing that the structural approach is centered on health systems, reinforces global governance, and embodies the Sustainable Development Goals (SDG), thus taking on a multi-sectoral dimension. This approach leverages the maximum potential of international cooperation by establishing structuring networks and promoting relations between partner countries through their national health institutions, schools of public health, and technical staff...
July 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28723985/rural-women-and-violence-situation-access-and-accessibility-limits-to-the-healthcare-network
#5
Marta Cocco da Costa, Ethel Bastos da Silva, Joannie Dos Santos Fachinelli Soares, Luana Cristina Borth, Fernanda Honnef
Objective: To analyze the access and accessibility to the healthcare network of women dwelling in rural contexts undergoing violence situation, as seen from the professionals' speeches. Method: A qualitative, exploratory, descriptive study with professionals from the healthcare network services about coping with violence in four municipalities in the northern region of Rio Grande do Sul. The information derived from interviews, which have been analyzed by thematic modality...
July 13, 2017: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/28723311/visual-perceptual-learning-and-models
#6
Barbara Dosher, Zhong-Lin Lu
Visual perceptual learning through practice or training can significantly improve performance on visual tasks. Originally seen as a manifestation of plasticity in the primary visual cortex, perceptual learning is more readily understood as improvements in the function of brain networks that integrate processes, including sensory representations, decision, attention, and reward, and balance plasticity with system stability. This review considers the primary phenomena of perceptual learning, theories of perceptual learning, and perceptual learning's effect on signal and noise in visual processing and decision...
July 19, 2017: Annual Review of Vision Science
https://www.readbyqxmd.com/read/28719228/successful-use-of-noninvasive-ventilation-in-chronic-obstructive-pulmonary-disease-how-do-high-performing-hospitals-do-it
#7
Kimberly A Fisher, Kathleen M Mazor, Sarah Goff, Mihaela S Stefan, Penelope S Pekow, Lauren A Williams, Vida Rastegar, Michael B Rothberg, Nicholas S Hill, Peter K Lindenauer
RATIONALE: Noninvasive ventilation (NIV) is a cornerstone of treatment for patients with severe exacerbations of chronic obstructive pulmonary disease (COPD) where it has been shown to reduce the need for intubation, hospital length of stay, and mortality. Despite high quality evidence and strong recommendations in clinical guidelines, use of NIV varies widely across hospitals. OBJECTIVE: To identify approaches used by hospitals which have been successful in implementing NIV to treat patients with severe exacerbations of COPD...
July 18, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28718324/physical-health-and-drug-safety-in-individuals-with-schizophrenia
#8
Tamara Pringsheim, Martina Kelly, Doug Urness, Michael Teehan, Zahinoor Ismail, David Gardner
BACKGROUND: While antipsychotic medications are the mainstay of therapy for individuals with schizophrenia and psychotic disorders, their use is associated with adverse effects on physical health that require the attention and care of prescribers. METHODS: We used the ADAPTE process to adapt existing guideline recommendations from the National Institute for Health and Care Excellence (NICE) and Scottish Intercollegiate Guidelines Network (SIGN) guidelines on the dosing of antipsychotics and antipsychotic polypharmacy, screening for adverse effects of antipsychotics, and management of metabolic and extrapyramidal side effects to the Canadian context...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28718290/enhanced-long-term-and-thermal-stability-of-polymer-solar-cells-in-air-at-high-humidity-with-the-formation-of-unusual-quantum-dot-networks
#9
Long Tan, Fan Yang, Mee Rahn Kim, Pandeng Li, Deepak Thrithamarassery Gangadharan, Joelle Margot, Ricardo Izquierdo, Mohamed Chaker, Dongling Ma
Due to the practical applications of polymer solar cells (PSCs), their stability recently has received increasing attention. Herein, a new strategy was developed to largely enhance the long-term and thermal stability of PSCs in air with a relatively high humidity of 50-60% without any encapsulation. In this strategy, semiconductor PbS/CdS core/shell quantum dots (QDs) were incorporated into the photoactive blend of poly(3-hexylthiophene) (P3HT) and phenyl-C61-butyric acid methyl ester (PCBM). By replacing the initial ligands of oleic acid with halide ligands on the surface of PbS/CdS QDs via solution-phase-ligand-exchange, we were able to form unusual, continuous QD networks in the film of P3HT:PCBM, which effectively stabilized the photoactive layer...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28718088/how-well-do-network-models-predict-observations-on-the-importance-of-predictability-in-network-models
#10
Jonas M B Haslbeck, Lourens J Waldorp
Network models are an increasingly popular way to abstract complex psychological phenomena. While studying the structure of network models has led to many important insights, little attention has been paid to how well they predict observations. This is despite the fact that predictability is crucial for judging the practical relevance of edges: for instance in clinical practice, predictability of a symptom indicates whether an intervention on that symptom through the symptom network is promising. We close this methodological gap by introducing nodewise predictability, which quantifies how well a given node can be predicted by all other nodes it is connected to in the network...
July 17, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28716967/contextual-and-developmental-differences-in-the-neural-architecture-of-cognitive-control
#11
Raluca Petrican, Cheryl L Grady
Since both development and context impact functional brain architecture, the neural connectivity signature of a cognitive or affective predisposition may similarly vary across different ages and circumstances. To test this hypothesis, we investigated the effects of age and cognitive versus social-affective context on the stable and time-varying neural architecture of inhibition, the putative core cognitive control component, in a subsample (N= 359 [22-36 yrs], 174 men) of the Human Connectome Project. Among younger individuals, a neural signature of superior inhibition emerged in both stable and dynamic connectivity analyses...
July 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28715889/a-robust-and-elastic-polymer-membrane-with-tunable-properties-for-gas-separation
#12
Peng-Fei Cao, Bingrui Li, Tao Hong, Kunyue Xing, Dmitry Nikolaevich Voylov, Shiwang Cheng, Panchao Yin, Alexander M Kisliuk, Shannon M Mahurin, Alexei P Sokolov, Tomonori Saito
Polymer membranes with the capability to process a massive volume of gas are especially attractive for practical applications of gas separation. Although much effort has been devoted to develop novel polymer membranes with increased selectivity, the overall gas-separation performance and lifetime of membrane are still negatively affected by the weak mechanical performance, low plasticization resistance and poor physical aging tolerance. Recently, elastic polymer membranes with tunable mechanical properties have been attracting significant attention due to their tremendous potential applications...
July 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28715777/regular-cannabis-and-alcohol-use-is-associated-with-resting-state-time-course-power-spectra-in-incarcerated-adolescents
#13
Sandra Thijssen, Barnaly Rashid, Shruti Gopal, Prashanth Nyalakanti, Vince D Calhoun, Kent A Kiehl
Cannabis and alcohol are believed to have widespread effects on the brain. Although adolescents are at increased risk for substance use, the adolescent brain may also be particularly vulnerable to the effects of drug exposure due to its rapid maturation. Here, we examined the association between cannabis and alcohol use duration and resting-state functional connectivity in a large sample of male juvenile delinquents. The present sample was drawn from the Southwest Advanced Neuroimaging Cohort, Youth sample, and from a youth detention facility in Wisconsin...
July 8, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28714891/structural-and-functional-neuroimaging-of-visual-hallucinations-in-lewy-body-disease-a-systematic-literature-review
#14
REVIEW
Stefania Pezzoli, Annachiara Cagnin, Oliver Bandmann, Annalena Venneri
Patients with Lewy body disease (LBD) frequently experience visual hallucinations (VH), well-formed images perceived without the presence of real stimuli. The structural and functional brain mechanisms underlying VH in LBD are still unclear. The present review summarises the current literature on the neural correlates of VH in LBD, namely Parkinson's disease (PD), and dementia with Lewy bodies (DLB). Following a systematic literature search, 56 neuroimaging studies of VH in PD and DLB were critically reviewed and evaluated for quality assessment...
July 15, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28714584/oscillations-during-observations-dynamic-oscillatory-networks-serving-visuospatial-attention
#15
Alex I Wiesman, Elizabeth Heinrichs-Graham, Amy L Proskovec, Timothy J McDermott, Tony W Wilson
The dynamic allocation of neural resources to discrete features within a visual scene enables us to react quickly and accurately to salient environmental circumstances. A network of bilateral cortical regions is known to subserve such visuospatial attention functions; however the oscillatory and functional connectivity dynamics of information coding within this network are not fully understood. Particularly, the coding of information within prototypical attention-network hubs and the subsecond functional connections formed between these hubs have not been adequately characterized...
July 17, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28714563/the-effect-of-prefrontal-transcranial-direct-current-stimulation-on-attention-network-function-in-healthy-volunteers
#16
Joanna Astrid Miler, Daniel Meron, David S Baldwin, Matthew Garner
OBJECTIVES: The effect of acute transcranial direct current stimulation (tDCS) on cortical attention networks remains unclear. We examined the effect of 20 min of 2 mA dorsolateral prefrontal cortex tDCS (bipolar balanced montage) on the efficiency of alerting, orienting and executive attention networks measured by the attention network test. MATERIALS AND METHODS: A between-subjects stratified randomized design compared active tDCS vs. sham tDCS on attention network function in healthy young adults...
July 17, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28714428/are-newly-added-and-lost-confidants-in-later-life-related-to-subsequent-mental-health
#17
Ella Schwartz, Howard Litwin
BACKGROUND: This study examined internal changes in the personal social networks of older people and the relationship between these changes and mental health over time. It focused on two key aspects: emotional closeness and contact frequency with lost and newly added confidants. METHODS: The study was based on data from the fourth (2011) and sixth (2015) waves of the Survey of Health, Ageing and Retirement in Europe (SHARE). The study sample consisted of respondents aged 65 years and older who participated in both waves (n = 14,101)...
July 17, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28713500/the-social-network-among-the-elderly-and-its-relationship-with-quality-of-life
#18
Fatemeh Bahramnezhad, Raheleh Chalik, Farideh Bastani, Masoumeh Taherpour, Elham Navab
INTRODUCTION: Attention to the needs of the elderly is a social necessity, and it seems that evaluating the social network and quality of life of the elderly can be useful in a better understanding of their needs. This study was performed to determine the relationship between the social network and the quality of life of the elderly in the city of Bojnoord in Iran. METHODS: In this cross-sectional study, 201 elderly people aged 60 years or more were selected by continuous and consecutive sampling method in Bojnoord, Iran in 2014...
May 2017: Electronic Physician
https://www.readbyqxmd.com/read/28713309/associations-among-different-internet-access-time-gender-and-cyberbullying-behaviors-in-taiwan-s-adolescents
#19
Cheng-Min Chao, Tai-Kuei Yu
With the increasing convenience of social networking sites and their interconnectedness with human interaction, verbal and image bullying have turned digital, making cyberbullying a new form of bullying attracting the attention of researchers, social workers, and schools. This study focuses on the status quo of attitude toward cyberbullying and cyberbullying behavior, explores associations of attitude toward behavior on cyberbullying behavior in gender and different internet access times. In a cross-sectional survey, adolescents were surveyed through self-report questionnaires, 13,864 respondents were received among 150 high schools in Taiwan...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28713255/the-impact-of-aerobic-exercise-on-fronto-parietal-network-connectivity-and-its-relation-to-mobility-an-exploratory-analysis-of-a-6-month-randomized-controlled-trial
#20
Chun L Hsu, John R Best, Shirley Wang, Michelle W Voss, Robin G Y Hsiung, Michelle Munkacsy, Winnie Cheung, Todd C Handy, Teresa Liu-Ambrose
Impaired mobility is a major concern for older adults and has significant consequences. While the widely accepted belief is that improved physical function underlies the effectiveness of targeted exercise training in improving mobility and reducing falls, recent evidence suggests cognitive and neural benefits gained through exercise may also play an important role in promoting mobility. However, the underlying neural mechanisms of this relationship are currently unclear. Thus, we hypothesize that 6 months of progressive aerobic exercise training would alter frontoparietal network (FPN) connectivity during a motor task among older adults with mild subcortical ischemic vascular cognitive impairment (SIVCI)-and exercise-induced changes in FPN connectivity would correlate with changes in mobility...
2017: Frontiers in Human Neuroscience
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