keyword
MENU ▼
Read by QxMD icon Read
search

prostate cancer, breast cancer

keyword
https://www.readbyqxmd.com/read/28109841/disruption-of-aromatase-homeostasis-as-the-cause-of-a-multiplicity-of-ailments-a-comprehensive-review
#1
REVIEW
Seema Patel
Human health is beset with a legion of ailments, which is exacerbated by the lifestyle errors. Out of the numerous enzymes in human body, aromatase, a cytochromes P450 enzyme is particularly very critical. Occurring at the crossroads of multiple signalling pathways, its homeostasis is vital. Unfortunately, medications, hormone therapy, chemical additives in food, and endocrine-disrupting personal care products are oscillating the aromatase concentration beyond the permissible level. As this enzyme converts androgens (C19) into estrogens (C18), its agitation has different outcomes in different genders and age groups...
January 18, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28109633/the-american-college-of-radiology-and-the-american-brachytherapy-society-practice-parameter-for-the-performance-of-low-dose-rate-brachytherapy
#2
Akila N Viswanathan, Beth A Erickson, Geoffrey S Ibbott, William Small, Patricia J Eifel
Brachytherapy is the use of radionuclides to treat malignancies or benign conditions by means of a radiation source placed close to or into the tumor or treatment site. This practice parameter refers only to the use of radionuclide brachytherapy. Brachytherapy alone or combined with external beam therapy plays an important role in the management and treatment of patients with cancer. Low-dose-rate (LDR) brachytherapy has traditionally been used for treating prostate, head and neck, breast, cervical, and endometrial cancers as well as obstructive bile duct, esophageal, or bronchial lesions...
January 2017: Brachytherapy
https://www.readbyqxmd.com/read/28108330/pleiotropic-responses-to-methionine-restriction
#3
Gene Ables, Jay Johnson
Methionine restriction (MR) extends lifespan across different species. The main responses of rodent models to MR are well-documented in adipose tissue (AT) and liver, which have reduced mass and improved insulin sensitivity, respectively. Recently, molecular mechanisms that improve healthspan have been identified in both organs during MR. In fat, MR induced a futile lipid cycle concomitant with beige AT accumulation, producing elevated energy expenditure. In liver, MR upregulated fibroblast growth factor 21 and improved glucose metabolism in aged mice and in response to a high-fat diet...
January 17, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28108012/-cancer-screening-in-france-10%C3%A2-years-of-analysis-of-behaviours-by-the-edifice-surveys
#4
REVIEW
François Eisinger, Xavier Pivot, Laurent Greillier, Sébastien Couraud, Alexis B Cortot, Chantal Touboul, Christine Lhomel, Jean-Yves Blay, Jean-François Morère, Jérôme Viguier
Accessibility to cancer screening in France has been facilitated by the implementation of organised programs (breast cancer and colorectal cancer) and by national recommendations (cervical cancer). Personal motivation may also trigger participation in prostate cancer screening. This paper proposes an overview of attitudes toward cancer screening among the general population over a period of more than 10 years and the perception of this behaviour by general practitioners. It is noteworthy that although certain cancer screening programmes, such as for breast cancer, are widely established throughout the population, uptake of others, such as for colorectal or prostate cancer, is contingent on sociological factors and vulnerability...
January 17, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28107352/coping-well-with-advanced-cancer-a-serial-qualitative-interview-study-with-patients-and-family-carers
#5
Catherine Walshe, Diane Roberts, Lynda Appleton, Lynn Calman, Paul Large, Mari Lloyd-Williams, Gunn Grande
OBJECTIVES: To understand successful strategies used by people to cope well when living with advanced cancer; to explore how professionals can support effective coping strategies; to understand how to support development of effective coping strategies for patients and family carers. DESIGN: Qualitative serial (4-12 week intervals) interview study with people with advanced cancer and their informal carers followed by focus groups. The iterative design had a novel focus on positive coping strategies...
2017: PloS One
https://www.readbyqxmd.com/read/28107334/distress-during-radiation-therapy-assessment-among-patients-with-breast-or-prostate-cancer%C3%A2
#6
Stephen J Stapleton, Teresa D Valerio, Kim Astroth, Shermian Woodhouse
BACKGROUND: Distress is regarded as the sixth vital sign in cancer care, but few studies describe distress in patients undergoing radiation therapy. 
. OBJECTIVES: The purpose of this study was to assess distress levels among patients with breast or prostate cancer undergoing radiation therapy and investigate which problems contribute to patients' distress levels. 
. METHODS: A retrospective medical record review was conducted for 217 patients with breast or prostate cancer at a midwestern community cancer center...
February 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28106907/subsequent-malignancies-among-long-term-survivors-of-hodgkin-lymphoma-and-non-hodgkin-lymphoma-a-pooled-analysis-of-german-cancer-registry-data-1990-2012
#7
Nadia Baras, Stefan Dahm, Jörg Haberland, Martin Janz, Katharina Emrich, Klaus Kraywinkel, Abdulgabar Salama
The increased risk of subsequent primary malignancies (SPM) in survivors of adult-onset Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) remains a challenging clinical problem worldwide. The German cancer registry database, pooled from 14 federal states, was used to calculate the standardized incidence ratio (SIR) and excess absolute risk (EAR) of SPM in 128 587 patients registered with first primary HL/NHL between 1990 and 2012. Conversely, SIRs were also calculated for a subsequent HL/NHL following other first cancers...
January 20, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28106301/uxt-is-a-lox-pp-interacting-protein-that-modulates-estrogen-receptor-alpha-activity-in-breast-cancer-cells
#8
Nuria Sánchez-Morgan, Kathrin H Kirsch, Philip C Trackman, Gail E Sonenshein
The lysyl oxidase proenzyme propeptide region (LOX-PP) is a tumor suppressor protein whose mechanism of action is not completely understood. Here, the Ubiquitously eXpressed Transcript (UXT) was identified in a yeast two-hybrid assay with LOX-PP as bait and confirmed as a novel LOX-PP associating protein. UXT, a prefoldin-like protein, is ubiquitous in human and mouse. Since UXT modulates androgen receptor transcriptional activity in prostate cancer, we studied its role in breast cancer. Breast tumors and derived cell lines overexpressed UXT...
January 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28106283/therapeutic-potential-of-curcumin-in-treatment-of-pancreatic-cancer-current-status-and-future-perspectives
#9
Mina Hosseini, Seyed Mahdi Hassanian, Elham Mohamamdazade, Soodabeh ShahidSales, Mina Maftouh, Hasan Fayazbakhsh, Majid Khazaei, Amir Avan
Pancreatic cancer is among the leading cause of deaths due to cancer with extremely poor prognosis. Gemcitabine is being used in the treatment of patient with pancreatic ductal adenocarcinoma (PDAC), although, the response rate is bellow 12%. A recent phase III trial revealed that FOLFIRINOX could be an option for the treatment of metastatic PDAC patients, although it is associated with increased toxicity. Therefore, identification of novel agents that either improves gemcitabine activity, within novel combinatorial approaches, or with a better efficacy than gemcitabine is warranted...
January 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28105922/differential-expression-of-alternatively-spliced-transcripts-related-to-energy-metabolism-in-colorectal-cancer
#10
Anastasiya Vladimirovna Snezhkina, George Sergeevich Krasnov, Andrew Rostislavovich Zaretsky, Alex Zhavoronkov, Kirill Mikhailovich Nyushko, Alexey Alexandrovich Moskalev, Irina Yurievna Karpova, Anastasiya Isaevna Afremova, Anastasiya Valerievna Lipatova, Dmitriy Vladimitovich Kochetkov, Maria Sergeena Fedorova, Nadezhda Nikolaevna Volchenko, Asiya Fayazovna Sadritdinova, Nataliya Vladimirovna Melnikova, Dmitry Vladimirovich Sidorov, Anatoly Yurievich Popov, Dmitry Valerievich Kalinin, Andrey Dmitrievich Kaprin, Boris Yakovlevich Alekseev, Alexey Alexandrovich Dmitriev, Anna Viktorovna Kudryavtseva
BACKGROUND: Colorectal cancer (CRC) is one of the most common malignant tumors worldwide. CRC molecular pathogenesis is heterogeneous and may be followed by mutations in oncogenes and tumor suppressor genes, chromosomal and microsatellite instability, alternative splicing alterations, hypermethylation of CpG islands, oxidative stress, impairment of different signaling pathways and energy metabolism. In the present work, we have studied the alterations of alternative splicing patterns of genes related to energy metabolism in CRC...
December 28, 2016: BMC Genomics
https://www.readbyqxmd.com/read/28105172/her2-gene-amplification-in-patients-with-prostate-cancer-evaluating-a-cish-based-method
#11
Nazanin Sharifi, Arash Salmaninejad, Samira Ferdosi, Abolfazl Nesaei Bajestani, Malihe Khaleghiyan, Mehrdad Asghari Estiar, Mansour Jamali, Mohammad Reza Nowroozi, Abbas Shakoori
Prostate cancer (PCa) is one of the most widespread malignancies in the world. The role of the human epidermal growth factor receptor 2 (HER2) in the pathogenesis and progression of human PCa remains poorly understood. In contradiction with breast cancer, studies on HER2 overexpression and gene amplification in PCa have produced varying results, although the HER2 oncogene has been implicated in the biology of numerous tumor types, and serves as a prognostic marker and therapeutic target in breast cancer. Technical challenges are considered the main reasons for data discrepancies...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28104597/preferences-about-information-and-decision-making-among-older-patients-with-and-without-cancer
#12
Elena Paillaud, Florence Canoui-Poitrine, Gwenaelle Varnier, Narges Anfasi-Ebadi, Ester Guery, Olivier Saint-Jean, Mathilde Gisselbrecht, Thomas Aparicio, Sylvie Bastuji-Garin, Marie Laurent, Philippe Caillet
BACKGROUND: information of older patients with cancer is crucial to ensure optimal care. OBJECTIVES: to compare older patients with and without cancer regarding their preferences about medical information, decision-making and surrogate designation. DESIGN: an intention-to-act questionnaire was completed by patients ≥70 y enroled in the ELderly CAncer PAtients cohort between January and June 2013 and by patients in the same age group enroled in a cross-sectional survey conducted in 2005 in acute geriatric wards...
January 18, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28104314/breast-prostate-and-thyroid-cancer-screening-tests-and-overdiagnosis
#13
Minsoo Jung
The purpose of this study was to examine overdiagnosis and overtreatment related to cancer screening and to review relevant reports and studies. A comprehensive search of peer-reviewed and gray literature was conducted for relevant studies published between January 2000 and December 2015 reporting breast, prostate, and thyroid cancer screening tests and overdiagnosis. This study revealed no dichotomy on where screening would lower risk or cause overdiagnosis and overtreatment. Many screening tests did both, that is, at population level, there were both benefit (decreased disease-specific mortality) and harm (overdiagnosis and overtreatment)...
December 20, 2016: Current Problems in Cancer
https://www.readbyqxmd.com/read/28104137/prostate-cancer-metastatic-to-the-renal-allograft-a-case-report
#14
A Alaini, P Singh, R Shah, E Fischer, K Ganta, T Barrett, K Servilla
Malignancy is a leading cause of morbidity and mortality in organ transplant recipients who receive immunosuppression. Cancers associated with viruses such as nonmelanotic skin cancer and Kaposi sarcoma occur in allograft recipients at rates that far exceed that in the general population. The increased risk and tumor type may depend not only on degree of immune system modulation but also on the type of organ transplanted. In kidney transplant recipients, the risk of cancers such as prostate and breast does not seem to be increased...
January 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28103940/methodological-choices-affect-cancer-incidence-rates-a-cohort-study
#15
Hannah L Brooke, Mats Talbäck, Maria Feychting, Rickard Ljung
BACKGROUND: Incidence rates are fundamental to epidemiology, but their magnitude and interpretation depend on methodological choices. We aimed to examine the extent to which the definition of the study population affects cancer incidence rates. METHODS: All primary cancer diagnoses in Sweden between 1958 and 2010 were identified from the national Cancer Register. Age-standardized and age-specific incidence rates of 29 cancer subtypes between 2000 and 2010 were calculated using four definitions of the study population: persons resident in Sweden 1) based on general population statistics; 2) with no previous subtype-specific cancer diagnosis; 3) with no previous cancer diagnosis except non-melanoma skin cancer; and 4) with no previous cancer diagnosis of any type...
January 19, 2017: Population Health Metrics
https://www.readbyqxmd.com/read/28098572/metastatic-organotropism-an-intrinsic-property-of-breast-cancer-molecular-subtypes
#16
Shi Wei, Gene P Siegal
It has long been known that some cancers have the propensity to metastasize to certain organs thus creating a nonrandom distribution of sites for distant relapse, a phenomenon known as "metastatic organotropism." Some of these examples include ovary primary to abdominal cavity, prostate primary to bone, and pancreas primary to liver. In contrast, other tumor types, such as mammary and renal cell carcinoma, can relapse in multiple organs although approximately half of advanced breast cancers metastasize to bone...
January 16, 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28096199/trends-in-radiation-therapy-among-cancer-survivors-in-the-united-states-2000-2030
#17
Alex K Bryant, Matthew Banegas, Maria E Martinez, Loren K Mell, James D Murphy
BACKGROUND: Although the number of cancer survivors has increased substantially over the past several decades, the composition of survivors treated with radiotherapy is not well defined. Radiotherapy carries unique long-term toxicity risks for cancer survivors. This study describes the current estimates and future projections of the epidemiology of five-year cancer survivors who receive radiation therapy. METHODS: We used cancer incidence and survival data from the Surveillance, Epidemiology, and End-Results (SEER) database linked to US Census data to estimate the number of five-year cancer survivors treated with radiation between 2000 and 2030...
January 17, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28093701/cancer-incidence-in-spain-2015
#18
J Galceran, A Ameijide, M Carulla, A Mateos, J R Quirós, D Rojas, A Alemán, A Torrella, M Chico, M Vicente, J M Díaz, N Larrañaga, R Marcos-Gragera, M J Sánchez, J Perucha, P Franch, C Navarro, E Ardanaz, J Bigorra, P Rodrigo, R Peris Bonet
PURPOSE: Periodic cancer incidence estimates of Spain from all existing population-based cancer registries at any given time are required. The objective of this study was to present the current situation of cancer incidence in Spain. METHODS: The Spanish Network of Cancer Registries (REDECAN) estimated the numbers of new cancer cases occurred in Spain in 2015 by applying the incidence-mortality ratios method. In the calculus, incidence data from population-based cancer registries and mortality data of all Spain were used...
January 16, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28089230/metastatic-fractures-of-long-limb-bones
#19
REVIEW
P Anract, D Biau, P Boudou-Rouquette
The diagnosis of pathological fracture should be considered routinely in patients with long limb-bone fractures. Investigations must be performed to establish the diagnosis of pathological fracture then to determine that the bone lesion is a metastasis. In over 85% of cases, the clinical evaluation combined with a detailed analysis of the radiographs is sufficient to determine that the fracture occurred at a tumour site. Aetiological investigations establish that the tumour is a metastasis. In some patients, the diagnosis of metastatic cancer antedates the fracture...
January 11, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28079518/angiotensin-receptor-blockers-and-the-risk-of-cancer-data-mining-of-a-spontaneous-reporting-database-and-a-claims-database%C3%A2
#20
Mai Fujimoto, Migiwa Kanou, Kouichi Hosomi, Mitsutaka Takada
OBJECTIVE: The aim of this study was to examine the associations between angiotensin receptor blockers (ARBs) and the risk of 10 major cancers by employing different pharmacoepidemiological assessments. MATERIALS AND METHODS: Data from the first quarter of 2004 through 2012 were downloaded from the US Food and Drug Administration Adverse Event Reporting System (FAERS). The reporting odds ratio (ROR) and information component (IC) were used to detect the signals...
January 12, 2017: International Journal of Clinical Pharmacology and Therapeutics
keyword
keyword
55211
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"