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Spinal cord injury

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https://www.readbyqxmd.com/read/29231595/-effects-of-electroacupuncture-on-activation-of-microglia-cells-in-spinal-cord-in-rats-with-neuropathic-pain
#1
Sisi Li, Pengpeng Gu, Wenzhan Tu, Xia Jiang, Wenci Chen, Qimiao Hu, Songhe Jiang
OBJECTIVE: To observe the effects of electroacupuncture (EA) on the activation of microglia cells in the L4 to L6 spinal cord in rats with neuropathic pain, so as to investigate whether EA could inhibit the activation of spinal microglial cells and regulate the expression of brain-derived neurotrophic factor (BDNF) to achieve the analgesic effect. METHODS: Forty male Sprague Dawley rats were randomly divided into a normal group, a sham-model group, a model group and an EA group, 10 rats in each one...
April 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231515/-reviews-on-acupuncture-for-cellular-signal-transduction-in-spinal-cord-injury
#2
REVIEW
Jisheng Liu, Hong Zhang, Guilan Huang, Ming Xu, Jian Zhang, Xiuting Yin
Investigating the influence of acupuncture on cellular signal transduction is an efficient pathway to reveal the action mechanism of acupuncture on spinal cord injury (SCI). In this study, the experiment research literature regarding acupuncture for SCI during past 10 years was reviewed and analyzed. As a result, it was found that acupuncture could regulate the expression of the first intercellular messenger as well as the second signal molecules including cyclic adenosine monophosphate, cyclic guanosine monophosphate, Ca2+, nitric oxide to intervene the apoptotic signaling pathway, Rho/Rock signaling pathway, Wnt signaling pathway, MAPK signaling pathway, Notch signaling pathway, etc...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29230638/application-of-the-sodium-hyaluronate-cntf-scaffolds-in-repairing-adult-rat-spinal-cord-injury-and-facilitating-neural-network-formation
#3
Yabin Xie, Wei Song, Wen Zhao, Yudan Gao, Junkui Shang, Peng Hao, Zhaoyang Yang, Hongmei Duan, Xiaoguang Li
The present study aimed to explore the potential of the sodium hyaluronate-CNTF (ciliary neurotrophic factor) scaffold in activating endogenous neurogenesis and facilitating neural network re-formation after the adult rat spinal cord injury (SCI). After completely cutting and removing a 5-mm adult rat T8 segment, a sodium hyaluronate-CNTF scaffold was implanted into the lesion area. Dil tracing and immunofluorescence staining were used to observe the proliferation, differentiation and integration of neural stem cells (NSCs) after SCI...
December 6, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/29230608/combinatorial-therapy-with-two-pro-coagulants-and-one-osmotic-agent-reduces-the-extent-of-the-lesion-in-the-acute-phase-of-spinal-cord-injury-in-the-rat
#4
Mathieu Boutonnet, Elisabeth Laemmel, Eric Vicaut, Jacques Duranteau, Marc Soubeyrand
BACKGROUND: Spinal cord injury (SCI) is a complex disease that leads to a motor, sensitive, and vegetative impairment. So far, single therapies are ineffective for treating SCI in humans and a multifactorial therapeutic approach may be required. The aim of this work was to assess the effect of a triple therapy (TT) associating two pro-coagulant therapies (tranexamic acid and fibrinogen) with an anti-edema therapy (hypertonic saline solution), on the extent of the lesion 24 h post-injury...
December 11, 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/29230560/non-functionalized-soft-alginate-hydrogel-promotes-locomotor-recovery-after-spinal-cord-injury-in-a-rat-hemimyelonectomy-model
#5
Kerim Hakan Sitoci-Ficici, Marina Matyash, Ortrud Uckermann, Roberta Galli, Elke Leipnitz, Robert Later, Chrysanthy Ikonomidou, Michael Gelinsky, Gabriele Schackert, Matthias Kirsch
BACKGROUND: Spinal cord injury (SCI) and the consecutive devastating neurological sequelae have an enormous individual and economic impact. Implantation of functionalized hydrogels is a promising approach, because they can serve as a matrix for the regenerating tissue, carry and release bioactive molecules and various cell types. We already demonstrated that non-functionalized soft alginate hydrogel supported axonal outgrowth and protected neurons against oxidative stress in vitro. Here, we investigated the effects of such soft alginate hydrogels on locomotor recovery in small and large spinal cord lesions...
December 11, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29230425/neuroprotective-potential-of-gentongping-in-rat-model-of-cervical-spondylotic-radiculopathy-targeting-ppar-%C3%AE-pathway
#6
Wen Sun, Kang Zheng, Bin Liu, Danping Fan, Hui Luo, Xiaoyuan Qu, Li Li, Xiaojuan He, Jianfeng Yi, Cheng Lu
Cervical spondylotic radiculopathy (CSR) is the most general form of spinal degenerative disease and is characterized by pain and numbness of the neck and arm. Gentongping (GTP) granule, as a classical Chinese patent medicine, has been widely used in curing CSR, whereas the underlying mechanism remains unclear. Therefore, the aim of this study is to explore the pharmacological mechanisms of GTP on CSR. The rat model of CSR was induced by spinal cord injury (SCI). Our results showed that GTP could significantly alleviate spontaneous pain as well as ameliorate gait...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29230100/dl-3-n-butylphthalide-prevents-the-disruption-of-blood-spinal-cord-barrier-via-inhibiting-endoplasmic-reticulum-stress-following-spinal-cord-injury
#7
Binbin Zheng, Yulong Zhou, Hongyu Zhang, Guangyong Yang, Zhenghua Hong, Dandan Han, Qingqing Wang, Zili He, Yanlong Liu, Fenzan Wu, Xie Zhang, Songlin Tong, Huazi Xu, Jian Xiao
After spinal cord injury (SCI), the destruction of blood-spinal cord barrier (BSCB) is shown to accelerate gathering of noxious blood-derived components in the nervous system, leading to secondary neurodegenerative damages. SCI activates endoplasmic reticulum stress (ER stress), which is considered to evoke secondary damages of neurons and glia. Recent evidence indicates that Dl-3-n-butylphthalide (NBP) has the neuroprotective effect in ischaemic brain injury, but whether it has protective effects on SCI or not is largely unclear...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29229841/predicting-glycosaminoglycan-surface-protein-interactions-and-implications-for-studying-axonal-growth
#8
Adam R Griffith, Claude J Rogers, Gregory M Miller, Ravinder Abrol, Linda C Hsieh-Wilson, William A Goddard
Cell-surface carbohydrates play important roles in numerous biological processes through their interactions with various protein-binding partners. These interactions are made possible by the vast structural diversity of carbohydrates and the diverse array of carbohydrate presentations on the cell surface. Among the most complex and important carbohydrates are glycosaminoglycans (GAGs), which display varied stereochemistry, chain lengths, and patterns of sulfation. GAG-protein interactions participate in neuronal development, angiogenesis, spinal cord injury, viral invasion, and immune response...
December 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29228863/parallel-evaluation-of-two-potassium-channel-blockers-in-restoring-conduction-in-mechanical-spinal-cord-injury-in-rat
#9
Jessica Page, Jonghyuck Park, Zhe Chen, Peng Cao, Riyi Shi
Myelin damage is a hallmark of spinal cord injury (SCI) and potassium channel blocker (PCB) is proven effective to restore axonal conduction and regain neurological function. Aiming to improve this therapy beyond the FDA-approved 4-AP, we have developed multiple new PCBs, with 4-AP-3-MeOH being the most potent and effective. The current study evaluated two PCBs, 4-AP-3-MeOH and 4-AP, in parallel in both ex vivo and in vivo rat mechanical SCI models. Specifically, 4-AP-3-MeOH induced significantly greater augmentation of axonal conduction than 4-AP in both acute and chronic injury...
December 11, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29228691/berberine-attenuated-pro-inflammatory-factors-and-protect-against-neuronal-damage-via-triggering-oligodendrocyte-autophagy-in-spinal-cord-injury
#10
Hongyu Wang, Chang Liu, Xifan Mei, Yang Cao, Zhanpeng Guo, Yajiang Yuan, Ziming Zhao, Changwei Song, Yue Guo, Zhaoliang Shen
Berberine exerts neuroprotective effect in neuroinflammation and neurodegeneration disease. However, berberine effect in acute spinal cord injury is yet to be elucidated. Herein, we investigated the neuroprotective effect of berberine in spinal cord injury (SCI). Sprague-Dawley rats were subjected to SCI by an intraperitoneal injection of berberine post-injury. The neurobehavioral recovery, cytokines of pro-inflammatory factors (TNF-α and IL-1β), autophagy-related proteins (LC3B, ATG16L, ATG7), and apoptosis-related protein cleaved caspase-3 were determined...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228020/transplantation-of-canine-olfactory-ensheathing-cells-producing-chondroitinase-abc-promotes-chondroitin-sulphate-proteoglycan-digestion-and-axonal-sprouting-following-spinal-cord-injury
#11
Darren Carwardine, Jonathan Prager, Jacob Neeves, Elizabeth M Muir, James Uney, Nicolas Granger, Liang-Fong Wong
Olfactory ensheathing cell (OEC) transplantation is a promising strategy for treating spinal cord injury (SCI), as has been demonstrated in experimental SCI models and naturally occurring SCI in dogs. However, the presence of chondroitin sulphate proteoglycans within the extracellular matrix of the glial scar can inhibit efficient axonal repair and limit the therapeutic potential of OECs. Here we have used lentiviral vectors to genetically modify canine OECs to continuously deliver mammalian chondroitinase ABC at the lesion site in order to degrade the inhibitory chondroitin sulphate proteoglycans in a rodent model of spinal cord injury...
2017: PloS One
https://www.readbyqxmd.com/read/29227787/major-destructive-asymptomatic-lumbar-charcot-lesion-treated-with-three-column-resection-and-short-segment-reconstruction-case-report-treatment-strategy-and-review-of-literature
#12
Kestutis Valancius, Gaurav Garg, Madalina Duicu, Ebbe Stender Hansen, Cody Bunger
Charcot's spine is a long-term complication of spinal cord injury. The lesion is often localized at the caudal end of long fusion constructs and distal to the level of paraplegia. However, cases are rare and the literature relevant to the management of Charcot's arthropathy is limited. This paper reviews the clinical features, diagnosis, and surgical management of post-traumatic spinal neuroarthropathy in the current literature. We present a rare case of adjacent level Charcot's lesion of the lumbar spine in a paraplegic patient, primarily treated for traumatic spinal cord lesion 39 years before current surgery...
2017: SICOT-J
https://www.readbyqxmd.com/read/29227141/cervical-porcupine-quill-foreign-body-involving-the-spinal-cord-of-a-dog-a-description-of-various-imaging-modality-findings
#13
Christelle Le Roux, Frans J Venter, Robert M Kirberger
Although porcupine quill injuries are common in dogs, the detailed appearance of the quill on diagnostic ultrasound, computed tomography, and magnetic resonance imaging has not been sufficiently described. A 4-year-old, intact, female Jack Russel terrier presented with severe neck pain and ataxia after an altercation with a porcupine 2 weeks earlier. Radiology, diagnostic ultrasound, computed tomography and magnetic resonance imaging were all utilised to identify a quill imbedded in the cervical vertebral canal and cervical musculature and were compared to each other...
December 8, 2017: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/29226660/bone-and-joint-diseases-in-present-and-future
#14
Yasuharu Nakashima, Ken Okazak, Koichiet Nakayama, Seiji Okada, Hideki Mizu-uchi
With the increase of elderly population, orthopaedic surgeons need to deal with the diseases related to aging, such as joint disorders and fragility fractures. The number of total joint replacements, for example, is two times more than it was 10 years ago. With these backgrounds, the Japanese Orthopaedic Association (JOA) has proposed the concept of locomotive syndrome; conditions under which the elderly have been receiving care services due to problems of the locomotive organs. To prevent geriatric or disuse syndrome, JOA is currently providing the care‒prevention programs such as the loco-check and loco-training...
January 2017: Fukuoka Igaku Zasshi, Hukuoka Acta Medica
https://www.readbyqxmd.com/read/29226126/prevalence-of-autonomic-dysreflexia-in-patients-with-spinal-cord-injury-above-t6
#15
Eun Sun Lee, Min Cheol Joo
Objective: To investigate the prevalence of autonomic dysreflexia (AD) using ambulatory blood pressure monitoring (ABPM) and the autonomic dysfunction following spinal cord injury (ADFSCI) questionnaire in patients with spinal cord injury (SCI) above T6. Methods: Twenty-eight patients diagnosed with SCI above T6 were enrolled. ABPM and ADFSCI were utilized to assess AD. Using ABPM, systolic blood pressure (SBP), diastolic blood pressure, and heart rate (HR) were measured at 30-minute intervals...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29225468/therapy-of-an-incomplete-spinal-cord-injury-by-intrathecal-injection-of-epo-and-subcutaneous-injection-of-epo-vitamin-c-and-g-csf
#16
Augustinus Bader, Martin Reinhardt, Achim Beuthe, Klaus Röhl, Shibashish Giri
Spinal cord injury is a rare disease with an incidence about 40 cases per million population in the USA. The most common reasons are traffic accidents, falls, violence and sports. A 53-year-old male patient presented with an incomplete tetraparesis as a result of a spinal cord injury after the accident. It was not possible to treat him with steroids because he was out of the therapeutic time period of 8 hours when he presented to the hospital. The main problem of spinal cord injuries is the secondary injury caused by inflammation and swelling of the spinal cord...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29225161/self-efficacy-and-pressure-ulcer-prevention-after-spinal-cord-injury-results-from-a-nationwide-community-survey-in-switzerland-swisci
#17
Kerstin Hug, Caroline Stumm, Isabelle Debecker, Carolina Saskia Fellinghauer, Claudio Peter, Magret Hund-Georgiadis
BACKGROUND: Pressure ulcers (PUs) are a common and severe health condition in persons with spinal cord injury (SCI). Skin-care strategies for PU prevention are usually provided during first rehabilitation. However, individuals with SCI often do not perform these strategies continuously, especially after discharge. The influence of psychological factors such as general self-efficacy (GSE) on the performance of PU prevention behavior has not yet been sufficiently explored. OBJECTIVE: To investigate if persons with higher levels of GSE are more likely to perform skin-care strategies for PU prevention regularly...
December 7, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29225159/histopathology-of-periarticular-non-hereditary-heterotopic-ossification
#18
REVIEW
Kristin L Foley, Nader Hebela, Mary Ann Keenan, Robert J Pignolo
In the mature adult skeleton, new bone formation is normally restricted to regeneration of osseous tissue at sites of fracture. However, heterotopic ossification, or the formation of bone outside the normal skeleton, can occur within muscle, adipose, or fibrous connective tissue. Periarticular non-hereditary heterotopic ossification (NHHO) may occur after musculoskeletal trauma, following CNS injury, with certain arthropathies, or following injury or surgery that is often sustained in the context of age-related pathology...
December 7, 2017: Bone
https://www.readbyqxmd.com/read/29224922/neurons-and-satellite-glial-cells-in-adult-rat-lumbar-dorsal-root-ganglia-express-connexin-36
#19
E Martha Pérez Armendariz, Monica Norcini, Beatriz Hernández-Tellez, Andrés Castell-Rodríguez, Cristina Coronel-Cruz, Raquel Guerrero Alquicira, Alexandra Sideris, Esperanza Recio-Pinto
Previous studies have shown that following peripheral nerve injury there was a downregulation of the gap junction protein connexin 36 (Cx36) in the spinal cord; however, it is not known whether Cx36 protein is expressed in the dorsal root ganglia (DRGs), nor if its levels are altered following peripheral nerve injuries. Here we address these aspects in the adult rat lumbar DRG. Cx36 mRNA was detected using qRT-PCR, and Cx36 protein was identified in DRG sections using immunohistochemistry (IHC) and immunofluorescence (IF)...
December 7, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/29224279/-overexpression-of-trpv1-after-periphery-nerve-injury-attenuates-nerve-regeneration-in-rats
#20
J Bai, Y Zhang, Y F Wang, J Lan, X Q Li
Objective: To observe the effect of the expressive or functional blockage of TRPV1 on nerve regeneration after sciatic trans-section injury. Methods: AMG-517, a kind of TRPV1 inhibitor, was injected into the surrounding area of the ipsilateral lumbar dorsal root ganglia while unilateral sciatic nerve was transected. A total of 24 healthy male Sprague-Dawley rats were divided into 4 groups: control group, injury only group, injury+ AMG-517 150 μg/kg group, injury+ AMG-517 300 μg/kg group. The injury only group was injected the same volume of medium...
December 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
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