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Spinal cord injury

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https://www.readbyqxmd.com/read/30247265/contribution-of-dorsal-root-ganglion-octamer-transcription-factor-1-to-neuropathic-pain-after-peripheral-nerve-injury
#1
Jingjing Yuan, Jing Wen, Shaogen Wu, Yuanyuan Mao, Kai Mo, Zhisong Li, Songxue Su, Hanwen Gu, Yanqiu Ai, Alex Bekker, Wei Zhang, Yuan-Xiang Tao
Neuropathic pain genesis is related to gene alterations in the dorsal root ganglion (DRG) following peripheral nerve injury. Transcription factors control gene expression. In this study, we investigated whether octamer transcription factor 1 (OCT1), a transcription factor, contributed to neuropathic pain caused by chronic constriction injury (CCI) of the sciatic nerve. CCI produced a time-dependent increase in the level of OCT1 protein in the ipsilateral L4/5 DRG, but not in the spinal cord. Blocking this increase through microinjection of OCT1 siRNA into the ipsilateral L4/5 DRG attenuated the initiation and maintenance of CCI-induced mechanical allodynia, heat hyperalgesia, and cold allodynia and improved morphine analgesia after CCI, without affecting basal responses to acute mechanical, heat, and cold stimuli as well as locomotor functions...
September 20, 2018: Pain
https://www.readbyqxmd.com/read/30247091/recovery-of-over-ground-walking-after-chronic-motor-complete-spinal-cord-injury
#2
Claudia A Angeli, Maxwell Boakye, Rebekah A Morton, Justin Vogt, Kristin Benton, Yangshen Chen, Christie K Ferreira, Susan J Harkema
Persons with motor complete spinal cord injury, signifying no voluntary movement or sphincter function below the level of injury but including retention of some sensation, do not recover independent walking. We tested intense locomotor treadmill training with weight support and simultaneous spinal cord epidural stimulation in four patients 2.5 to 3.3 years after traumatic spinal injury and after failure to improve with locomotor training alone. Two patients, one with damage to the mid-cervical region and one with damage to the high-thoracic region, achieved over-ground walking (not on a treadmill) after 278 sessions of epidural stimulation and gait training over a period of 85 weeks and 81 sessions over a period of 15 weeks, respectively, and all four achieved independent standing and trunk stability...
September 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/30245852/is-fitbit-charge-2-a-feasible-instrument-to-monitor-daily-physical-activity-and-handbike-training-in-persons-with-spinal-cord-injury-a-pilot-study
#3
M C Maijers, O Verschuren, J M Stolwijk-Swüste, C F van Koppenhagen, S de Groot, M W M Post
Study design: It is a longitudinal pilot study. Objectives: To investigate the feasibility of a low-cost and widely used fitness tracker with step count and heart rate data to monitor daily physical activity in wheelchair users with spinal cord injury (SCI). Setting: Dutch community. Methods: Six participants with SCI who were in training for a handbike event were recruited. They were asked to wear a Fitbit Charge 2® 24 h a day for at least 2 weeks and were questioned about the utility and user-friendliness of this device...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/30245851/ancillary-benefits-of-bladder-chemodenervation-for-sci-neurogenic-bladder
#4
Brandon M Haynes, Nathan C Osbun, Claire C Yang
Study design: Case series. Objective: Bladder chemodenervation is effective in treating neurogenic detrusor overactivity (NDO) in patients with neurogenic bladder due to spinal cord injury. Anecdotal reports also describe the improvement of non-bladder symptoms, specifically those related to autonomic dysreflexia (AD) and muscle spasticity. We conducted a study to further investigate this phenomenon. Setting: USA, Urban Tertiary Care Center...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/30245710/cortical-aav-cntf-gene-therapy-combined-with-intraspinal-mesenchymal-precursor-cell-transplantation-promotes-functional-and-morphological-outcomes-after-spinal-cord-injury-in-adult-rats
#5
Stuart I Hodgetts, Jun Han Yoon, Alysia Fogliani, Emmanuel A Akinpelu, Danii Baron-Heeris, Imke G J Houwers, Lachlan P G Wheeler, Bernadette T Majda, Sreya Santhakumar, Sarah J Lovett, Emma Duce, Margaret A Pollett, Tylie M Wiseman, Brooke Fehily, Alan R Harvey
Ciliary neurotrophic factor (CNTF) promotes survival and enhances long-distance regeneration of injured axons in parts of the adult CNS. Here we tested whether CNTF gene therapy targeting corticospinal neurons (CSN) in motor-related regions of the cerebral cortex promotes plasticity and regrowth of axons projecting into the female adult F344 rat spinal cord after moderate thoracic (T10) contusion injury (SCI). Cortical neurons were transduced with a bi cis tronic adeno-associated viral vector (AAV1) expressing a secretory form of CNTF coupled to mCHERRY (AAV-CNTFmCherry ) or with control AAV only (AAV-GFP) two weeks prior to SCI...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/30244639/early-surgical-decompression-improves-neurological-outcome-after-complete-traumatic-cervical-spinal-cord-injury-a-meta-analysis
#6
Paula Valerie Ter Wengel, Philip C de Witt Hamer, Jonah C Pauptit, Niels A Van der Gaag, F Cumhur Oner, William Peter Vandertop
In patients with traumatic spinal cord injury (tSCI) a distinction in surgical urgency is made on the basis of severity of initial neurological injury. The optimal timing of surgical decompression, as well as its impact on neurological recovery, is as of yet undetermined. This study addresses neurological improvement after early and late surgery for complete and incomplete cervical traumatic spinal cord injury. A systematic search retrieved 15 publications of observational studies reporting outcome measurements after surgery in 1...
September 22, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/30243665/astaxanthin-attenuates-neuroinflammation-contributed-to-the-neuropathic-pain-and-motor-dysfunction-following-compression-spinal-cord-injury
#7
Sajad Fakhri, Leila Dargahi, Fatemeh Abbaszadeh, Masoumeh Jorjani
Spinal cord injury (SCI) is a debilitating condition in which inflammatory responses in the secondary phase of injury leads to long lasting sensory-motor dysfunction. The medicinal therapy of SCI complications is still a clinical challenge. Understanding the molecular pathways underlying the progress of damage will help to find new therapeutic candidates. Astaxanthin (AST) is a ketocarotenoid which has shown anti-inflammatory effects in models of traumatic brain injury. In the present study, we examined its potential in the elimination of SCI damage through glutamatergic-phospo p38 mitogen-activated protein kinase (p-p38MAPK) signaling pathway...
September 19, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/30243599/fatty-infiltration-of-the-cervical-multifidus-musculature-and-their-clinical-correlates-in-spondylotic-myelopathy
#8
Michael Cloney, Andrew C Smith, Taylor Coffey, Monica Paliwal, Yasin Dhaher, Todd Parrish, James Elliott, Zachary A Smith
Cervical spondylotic myelopathy (CSM) is among the most common spinal cord disorders of the elderly. Muscle fat infiltration (MFI), a potential pathological sign of muscle adiposity, may contribute to or be associated with pain/disability/impairments in patients with CSM. We examined the relationship between MFI and CSM's clinical manifestations by enrolling nine CSM patients and five aged-matched controls to undergo MRI imaging of the cervical spine with MFI. A blinded investigator calculated MFI for each of the bilateral multifidii muscles from C3 to C7 on the MRI images...
September 19, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/30242310/epidural-spinal-cord-stimulation-training-and-sustained-recovery-of-cardiovascular-function-in-individuals-with-chronic-cervical-spinal-cord-injury
#9
Susan J Harkema, Bonnie Legg Ditterline, Siqi Wang, Sevda Aslan, Claudia A Angeli, Alexander Ovechkin, Glenn A Hirsch
No abstract text is available yet for this article.
September 17, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/30241980/early-outcomes-after-branched-and-fenestrated-endovascular-aortic-repair-in-octogenarians
#10
Vladimir Makaloski, Tilo Kölbel, Fiona Rohlffs, Christian A Behrendt, Yuk Law, Eike S Debus, Nikolaos Tsilimparis
AIM: To compare early outcome after complex endovascular aortic repair in octogenarians (age ≥ 80 years) versus non-octogenarians (age < 80 years) treated with fenestrated or branched stent grafts. METHODS: Single centre retrospective analysis from a prospectively collected database of all patients undergoing repair with fenestrated or branched stent grafts for para/suprarenal aortic aneurysm, type Ia endoleak after previous endovascular aortic repair, and thoraco-abdominal aortic aneurysm between January 2015 and December 2017...
September 18, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/30241940/decreased-expression-of-lats1-correlates-with-astrogliosis-after-spinal-cord-injury
#11
Yi Wang, Minhao Chen
Large tumor suppressor kinase 1 (LATS1) is a serine/threonine kinase of the AGC kinase family in mammals and involved in various biological processes, it is a key regulator of cell cycle progression. However, the role of LATS1 in central nervous system trauma is still unknown. In present study, we performed an acute spinal cord injury (SCI) model in adult rats and investigated the dynamic changes of LATS1 expression in the spinal cord. We found that LATS1 protein levels were significantly decreased at day 1 after injury...
September 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30239271/cervical-osteogenic-degeneration-in-japanese-professional-wrestlers-and-its-relationship-to-cervical-spine-injury
#12
Manabu Sasaki, Shunji Asamoto, Masao Umegaki, Katsumi Matsumoto
OBJECTIVE: This study aimed to investigate the characteristics of cervical degeneration in Japanese professional wrestlers and its relationship with the risk of cervical spine injury (CSI). METHODS: Since 2012, 27 Japanese male wrestlers belonging to a professional wrestling association have undergone periodical medical examinations of the cervical spine. If neurological symptoms were observed in the wrestlers, the resident trainers urged them to undergo a brief examination at the authors' institutions...
September 21, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/30238720/-the-role-of-glial-scar-on-axonal-regeneration-after-spinal-cord-injury
#13
Xing Li, Jiayin Li, Zhifeng Xiao, Jianwu Dai
The 'glial scar' has been widely studied in the regeneration of spinal cord injury (SCI). For decades, mainstream scientific concept considers glial scar as a 'physical barrier' to impede axonal regeneration after SCI. Moreover, some extracellular molecules produced by glial scar are also regarded as axonal growth inhibitors. With the development of technology and the progress of research, multiple lines of new evidence challenge the pre-existing traditional notions in SCI repair, including the role of glial scar...
August 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/30237606/cervical-spine-evaluation-in-pediatric-trauma-a-review-and-an-update-of-current-concepts
#14
Nirmal Raj Gopinathan, Vibhu Krishnan Viswanathan, Alvin H Crawford
The clinical presentation and diagnostic workup in pediatric cervical spine injuries (CSI) are different from adults owing to the unique anatomy and relative immaturity. The current article reviews the existing literature regarding the uniqueness of these injuries and discusses the current guidelines of radiological evaluation. A PubMed search was conducted using keywords "paediatric cervical spine injuries" or "paediatric cervical spine trauma." Six hundred and ninety two articles were available in total...
September 2018: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/30236409/veterinary-neurologic-rehabilitation-the-rationale-for-a-comprehensive-approach
#15
REVIEW
Lauren R Frank, Patrick F P Roynard
The increase in client willingness to pursue surgical procedures, the heightened perceived value of veterinary patients, and the desire to provide comprehensive medical care have driven the recent demand of using an integrative treatment approach in veterinary rehabilitation. Physical therapy following neurologic injury has been the standard of care in human medicine for decades, whereas similar rehabilitation techniques have only recently been adapted and utilized in veterinary medicine. Spinal cord injury is the most common neurologic disease currently addressed by veterinary rehabilitation specialists and will be the primary focus of this review; however, research in other neurologic conditions will also be discussed...
June 2018: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/30236045/diaphragm-muscle-function-following-mid-cervical-contusion-injury-in-rats
#16
Obaid U Khurram, Matthew J Fogarty, Sabhya Rana, Pangdra Vang, Gary C Sieck, Carlos B Mantilla
Mid-cervical spinal cord contusion injury results in tissue damage, disruption of spinal pathways, and motor neuron loss. Unilateral C4 contusion results in loss of 40-50% of phrenic motor neurons ipsilateral to the injury (~25% of the total phrenic motor neuron pool). Over time after unilateral C4 contusion injury, diaphragm muscle (DIAm) electromyogram (EMG) activity increases both contralateral and ipsilateral to the side of injury in rats, suggesting compensation due to increased activation of the surviving motor neurons...
September 20, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/30235970/predictors-of-response-to-4-aminopyridine-in-chronic-canine-spinal-cord-injury
#17
Melissa Lewis, Eric B Laber, Natasha Olby
4-Aminopyridine (4AP), a potassium channel antagonist, can improve hind limb motor function in dogs with chronic thoracolumbar spinal cord injury (SCI) but individual response is variable. We hypothesized that injury characteristics would differ between dogs that do and do not respond to 4AP. Our objective was to compare clinical, electrodiagnostic, gait and imaging variables between dogs that do and do not respond to 4AP to identify predictors of response. Thirty-four dogs with permanent deficits after acute thoracolumbar SCI were enrolled...
September 20, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/30234812/heterotopic-ossification-and-spinal-cord-injury
#18
Chrissa Sioka, Andreas Fotopoulos
No abstract text is available yet for this article.
September 17, 2018: Spine
https://www.readbyqxmd.com/read/30234810/epidemiological-state-predictors-of-early-mortality-and-predictive-models-for-traumatic-spinal-cord-injury-a-multicenter-nationwide-cohort-study
#19
Keita Shibahashi, Masahiro Nishida, Yoshihiro Okura, Yuichi Hamabe
STUDY DESIGN: Multi-center, retrospective cohort study. OBJECTIVE: To determine the epidemiology, identify predictors of early mortality, and develop predictive models for traumatic spinal cord injury (SCI). SUMMARY OF BACKGROUND DATA: Despite improved initial care and management strategies, traumatic SCI remains a devastating event. Knowledge of the epidemiological state and predictive factors for mortality is important for developing strategies and counseling; however, they have not been adequately investigated, and predictive modeling regarding outcomes remains an underused modality for patients with traumatic SCI...
September 17, 2018: Spine
https://www.readbyqxmd.com/read/30234068/downregulation-of-matrix-metalloproteinases-2-and-9-is-involved-in-the-protective-effect-of-trehalose-on-spinal-cord-injury
#20
Masoumeh Mirzaie, Mehrnaz Karimi, Hossein Fallah, Mohammad Khaksari, Mahdieh Nazari-Robati
Upregulation of matrix metalloproteinases (MMPs), in particular MMP-2 and MMP-9 contributes to secondary pathogenesis of spinal cord injury (SCI) via promoting inflammation. Recently, we have reported that trehalose suppresses inflammatory responses following SCI. Therefore, we investigated the effect of trehalose on MMP-2 and MMP-9 expression in SCI. A weight-drop contusion SCI was induced in male rats. Then, the animals received trehalose at three doses of 10 (T10), 100 (T100) and 1000 (T1000) mM intrathecally...
2018: International Journal of Molecular and Cellular Medicine
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