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https://www.readbyqxmd.com/read/29770166/free-radical-damage-in-ischemia-reperfusion-injury-an-obstacle-in-acute-ischemic-stroke-after-revascularization-therapy
#1
REVIEW
Ming-Shuo Sun, Hang Jin, Xin Sun, Shuo Huang, Fu-Liang Zhang, Zhen-Ni Guo, Yi Yang
Acute ischemic stroke is a common cause of morbidity and mortality worldwide. Thrombolysis with recombinant tissue plasminogen activator and endovascular thrombectomy are the main revascularization therapies for acute ischemic stroke. However, ischemia-reperfusion injury after revascularization therapy can result in worsening outcomes. Among all possible pathological mechanisms of ischemia-reperfusion injury, free radical damage (mainly oxidative/nitrosative stress injury) has been found to play a key role in the process...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29760792/the-emerging-role-of-circular-rnas-in-hepatocellular-carcinoma
#2
REVIEW
Li-Peng Qiu, Yi-Hang Wu, Xiao-Feng Yu, Qi Tang, Liang Chen, Ke-Ping Chen
Hepatocellular carcinoma (HCC) ranks the third leading cause of cancer death in the world and has a notably low survival rate. Circular RNAs (circRNAs) are newly classed non-coding RNA (ncRNA) members that are capable of regulating gene expression at transcription or post-transcription levels. Recent studies demonstrate that some circRNAs are differentially expressed in HCC, and the deregulation of these circRNAs is associated with the clinical pathological and prognostic significance. They also play essential roles in HCC progression, and contribute to cell proliferation, migration, invasion and metastasis by targeting different microRNAs (miRNAs) and protein-coding genes...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29749758/the-role-of-mir-92b-in-cholangiocarcinoma-patients
#3
Min-Hang Zhou, Hong-Wei Zhou, Mo Liu, Jun-Zhong Sun
PURPOSE: The role of microRNA (miRNA) in cholangiocarcinoma was not clear. The aim of this study was to find the potential diagnostic and prognostic miRNA in cholangiocarcinoma patients. METHODS: The miRNA expression profiles in cholangiocarcinoma patients from The Cancer Genome Atlas and Gene Expression Omnibus (GSE53870) were analyzed. The comparison of overall survival was performed using the Kaplan-Meier method. The targeted genes of prognostic miRNA were identified in miRanda, PicTar, or TargetScan, and their cell signaling pathways were analyzed by the Database for Annotation, Visualization and Integrated Discovery...
April 1, 2018: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29704853/postmortem-blood-alcohol-content-among-late-middle-aged-and-older-suicide-decedents-associations-with-suicide-precipitating-risk-factors-means-and-other-drug-toxicology
#4
Namkee G Choi, Diana M DiNitto, Atami O Sagna, C Nathan Marti
BACKGROUND: This study examined blood alcohol content (BAC) among suicide decedents aged 50+ and its associations with suicide precipitating/risk factors, means, and other drug toxicology. METHODS: The National Violent Death Reporting System, 2005-2015, provided data (N = 56,118 for all suicide decedents and N = 29,115 with alcohol test results). We used logistic regression models, with BAC > 0.0 (BAC positive) and BAC > = 0.08 (intoxication) as the dependent variables...
April 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29703993/cortical-inhibitory-markers-of-lifetime-suicidal-behavior-in-depressed-adolescents
#5
Charles P Lewis, Paul A Nakonezny, Caren J Blacker, Jennifer L Vande Voort, John D Port, Gregory A Worrell, Hang Joon Jo, Zafiris J Daskalakis, Paul E Croarkin
Although suicide is the second-leading cause of death in adolescents and young adults worldwide, little progress has been made in developing reliable biological markers of suicide risk and suicidal behavior. Converging evidence suggests that excitatory and inhibitory cortical processes mediated by the neurotransmitters glutamate and γ-aminobutyric acid (GABA) are dysregulated in suicidal individuals. This study utilized single- and paired-pulse transcranial magnetic stimulation (TMS) to assess excitatory and inhibitory cortical functioning in healthy control adolescents (n = 20), depressed adolescents without any history of suicidal behavior ("Depressed", n = 37), and depressed adolescents with lifetime history of suicidal behavior ("Depressed+SB", n = 17)...
March 14, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29698247/higher-heart-weight-in-new-zealand-m%C3%A4-ori-and-pacific-islanders
#6
Winston Philcox, Jack Garland, Faseeh Zaidi, Paul Morrow, Kilak Kesha, Simon Stables, Christopher X Wong, Amy Spark, Rexson Tse
Heart weight is dependent on sex, age, height, and weight. Although previous autopsy studies showed no differences in heart weight between different ethnic groups, none have examined the New Zealand population of Māori and Pacific Islanders (Polynesians). The presented study compared heart weights between 101 European and 85 Polynesian suicide hanging deaths from New Zealand. Univariate linear regression coefficients for age, male sex, height, body weight, body mass index, and Polynesian ethnicity were positive and significant (P < 0...
April 26, 2018: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/29687285/anti-cancer-effect-of-xao-tam-phan-paramignya-trimera-methanol-root-extract-on-human-breast-cancer-cell-line-mcf-7-in-3d-model
#7
Lam-Huyen Nguyen-Thi, Sinh Truong Nguyen, Thao Phuong Tran, Chinh-Nhan Phan-Lu, Trung The Van, Phuc Van Pham
BACKGROUND: Cancer is one of the leading causes of death in the world. A great deal of effort has been made to discover new agents for cancer treatment. Xao tam phan (Paramignya trimera) is a traditional medicine of Vietnam used in cancer treatment for a long time, yet there is not much scientific evidence proving its anticancer potency. The study aimed to evaluate the toxicity of Paramignya trimera extract (PTE) on multicellular tumor spheres (MCTS) of MCF-7 cells using hanging drop technique...
April 24, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29678905/phosphorylation-of-xiap-at-threonine-180-controls-its-activity-in-wnt-signaling
#8
Victoria H Ng, Brian I Hang, Leah M Sawyer, Leif R Neitzel, Emily E Crispi, Kristie L Rose, Tessa M Popay, Alison Zhong, Laura A Lee, William P Tansey, Stacey Huppert, Ethan Lee
X-linked Inhibitor of Apoptosis (XIAP) plays an important role in preventing apoptotic cell death. XIAP has been shown to participate in signaling pathways, including Wnt signaling. XIAP regulates Wnt signaling by promoting the monoubiquitination of the co-repressor Groucho/TLE, decreasing its affinity for TCF/Lef and allowing assembly of transcriptionally active β-catenin-TCF/Lef complexes. We now demonstrate that XIAP is phosphorylated by GSK3 at threonine 180 and that an alanine mutant (XIAPT180A ) exhibits decreased Wnt activity compared to wild-type XIAP in cultured human cells and in Xenopus embryos...
April 20, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29671352/huntington-s-disease-novel-therapeutic-perspectives-hanging-in-the-balance
#9
Ana Saavedra, Gerardo García-Díaz Barriga, Esther Pérez-Navarro, Jordi Alberch
Huntington's disease (HD), an autosomal dominant neurodegenerative disorder caused by an expansion of CAG repeats in the huntingtin gene, has long been characterized by the presence of motor symptoms due to the loss of striatal projection neurons. Cognitive dysfunction and neuropsychiatric symptoms are also present and they occur in the absence of cell death in most mouse models, pointing to neuronal dysfunction and abnormal synaptic plasticity as causative mechanisms. Areas covered: Here, we focus on those common mechanisms altered by the presence of mutant huntingtin affecting corticostriatal and hippocampal function as therapeutic targets that could prove beneficial to ameliorate both cognitive and motor function in HD...
April 19, 2018: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29667630/-the-principal-and-auxiliary-immunohistochemical-markers-of-intravital-mechanical-strangulation-asphyxia
#10
D V Bogomolov, V A Fetisov, O P Denisova, Yu V Zbrueva, G G Semenov
The objective of the present study was the evaluation of the auxiliary methods for the diagnostics of the intravital formation of the constriction marks; the secondary objective was to determine the pace at which the death and asphyxia occur. MATERIAL AND METHODS: The materials on which the study was based included 17 cases of mechanical strangulation asphyxia involving 13 men and 4 women at the age from 8 to 28 years. All cases of hanging were associated with different blood alcohol levels...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29658097/anesthetized-by-chloroform-before-hanging
#11
Amal Nishantha Vadysinghe, Murugaphillai Sivasubramanium
We present a unique case of suicidal hanging. The deceased was a 31-year-old male who was found hanging from a tree in a dense thicket, with his lower limbs in contact with the ground (partial suspension). There was an apparatus similar to a facial mask placed around his nose and mouth. A strong chemical smell was emanating from the apparatus, which was identified as chloroform (Formyl trichloride/CHCl3 ). A ligature with a soft cloth beneath it was around his neck. A ligature mark was present around the neck...
April 16, 2018: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29620623/suicidal-hanging-donors-for-lung-transplantation-is-this-chapter-still-closed-midterm-experience-from-a-single-center-in-united-kingdom
#12
Olga Ananiadou, Bastian Schmack, Bartlomiej Zych, Anton Sabashnikov, Diana Garcia-Saez, Prashant Mohite, Alexander Weymann, Ashham Mansur, Mohamed Zeriouh, Nandor Marczin, Fabio De Robertis, Andre Rüdiger Simon, Aron-Frederik Popov
In the context of limited donor pool in cardiothoracic transplantation, utilization of organs from high risk donors, such as suicidal hanging donors, while ensuring safety, is under consideration. We sought to evaluate the outcomes of lung transplantations (LTx) that use organs from this group.Between January 2011 and December 2015, 265 LTx were performed at our center. Twenty-two recipients received lungs from donors after suicidal hanging (group 1). The remaining 243 transplantations were used as a control (group 2)...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29619927/joinpoint-regression-analysis-of-suicides-in-denmark-during-1980-2015
#13
Susanne Mahmood Dyvesether, Merete Nordentoft, Julie Lyng Forman, Annette Erlangsen
INTRODUCTION: Major advances have been achieved in suicide prevention over the past decades. Effective suicide prevention requires vigilant monitoring of suicide trends. The aim of this study was to assess the change in the Danish suicide rate over time using joinpoint regression analysis and to examine the distribution of suicide methods in the 1980-2015 period. METHODS: Nationwide register data were obtained from the Central Research Register and the Danish Cause of Death Register...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619616/association-between-suicide-and-environmental-variables-in-the-north-of-spain-a-14-year-analysis
#14
Maite Santurtún, Arturo Sanchez-Lorenzo, Álvaro Del Real, María T Zarrabeitia, Ana Santurtún
Suicide is a serious public health problem around the world. Since the nineteenth century, the impact of socio-environmental factors on suicide has attracted much public attention, especially in the context of global climate change. We have performed a retrospective correlation study that analyzes the demographic pattern of suicide in Cantabria, a northern coastland region of Spain. Moreover, we have created a multivariable binomial regression model to study the relationship between suicide and environmental factors (atmospheric pollutants and meteorological variables) among January 1, 2000, and December 31, 2013 in the province...
April 4, 2018: Culture, Medicine and Psychiatry
https://www.readbyqxmd.com/read/29618817/fatal-swine-acute-diarrhoea-syndrome-caused-by-an-hku2-related-coronavirus-of-bat-origin
#15
Peng Zhou, Hang Fan, Tian Lan, Xing-Lou Yang, Wei-Feng Shi, Wei Zhang, Yan Zhu, Ya-Wei Zhang, Qing-Mei Xie, Shailendra Mani, Xiao-Shuang Zheng, Bei Li, Jin-Man Li, Hua Guo, Guang-Qian Pei, Xiao-Ping An, Jun-Wei Chen, Ling Zhou, Kai-Jie Mai, Zi-Xian Wu, Di Li, Danielle E Anderson, Li-Biao Zhang, Shi-Yue Li, Zhi-Qiang Mi, Tong-Tong He, Feng Cong, Peng-Ju Guo, Ren Huang, Yun Luo, Xiang-Ling Liu, Jing Chen, Yong Huang, Qiang Sun, Xiang-Li-Lan Zhang, Yuan-Yuan Wang, Shao-Zhen Xing, Yan-Shan Chen, Yuan Sun, Juan Li, Peter Daszak, Lin-Fa Wang, Zheng-Li Shi, Yi-Gang Tong, Jing-Yun Ma
Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health1 . Bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (SARS)2-10 . Here we provide virological, epidemiological, evolutionary and experimental evidence that a novel HKU2-related bat coronavirus, swine acute diarrhoea syndrome coronavirus (SADS-CoV), is the aetiological agent that was responsible for a large-scale outbreak of fatal disease in pigs in China that has caused the death of 24,693 piglets across four farms...
April 4, 2018: Nature
https://www.readbyqxmd.com/read/29615164/profile-of-asphyxial-deaths-in-faisalabad-a-10-year-study
#16
Mobin Inam Pal, Altaf Pervez Qasim, Mohammad Naeem, Humera Arshad, Ahmad Saeed
OBJECTIVE: To determine the frequency of violent asphyxial deaths in Faisalabad over a span of a decade; and assessing the age and gender vulnerability. STUDY DESIGN: Descriptive cross-sectional study. PLACE AND DURATION OF STUDY: Department of Forensic Medicine and Toxicology, Punjab Medical College, Faisalabad, from January 2007 to December 2016. METHODOLOGY: Cases identified as violent asphyxial deaths according to police inquests and findings of the medico-legal examiners were computed...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29601598/outer-membrane-vesicles-from-neisseria-gonorrhoeae-target-porb-to-mitochondria-and-induce-apoptosis
#17
Pankaj Deo, Seong H Chow, Iain D Hay, Oded Kleifeld, Adam Costin, Kirstin D Elgass, Jhih-Hang Jiang, Georg Ramm, Kipros Gabriel, Gordon Dougan, Trevor Lithgow, Eva Heinz, Thomas Naderer
Neisseria gonorrhoeae causes the sexually transmitted disease gonorrhoea by evading innate immunity. Colonizing the mucosa of the reproductive tract depends on the bacterial outer membrane porin, PorB, which is essential for ion and nutrient uptake. PorB is also targeted to host mitochondria and regulates apoptosis pathways to promote infections. How PorB traffics from the outer membrane of N. gonorrhoeae to mitochondria and whether it modulates innate immune cells, such as macrophages, remains unclear. Here, we show that N...
March 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29599099/predictive-value-of-acute-kidney-injury-for-major-adverse-cardiovascular-events-following-tricuspid-annuloplasty-a-comparison-of-three-consensus-criteria
#18
Mei-Zhen Wu, Yan Chen, Wing-Kok Au, Daniel Chan, Ko-Yung Sit, Kar-Lai Ho, Lai-Ming Ho, Yui-Ming Lam, Chu-Pak Lau, Tak-Mao Chan, Hung-Fat Tse, Kai-Hang Yiu
BACKGROUND: Tricuspid annuloplasty (TA) is increasingly being performed, but the clinical outcome is unsatisfactory. Acute kidney injury (AKI) is a common complication following cardiac surgery and predicts outcome. Nonetheless the occurrence rate and prognostic value of AKI after TA are unclear. METHODS: This study reviewed 339 consecutive patients (age 65±11 years; male 42%) who underwent TA. The incidence of AKI was defined according to risk/injury/failure/loss/end stage (RIFLE), acute kidney injury network (AKIN), and kidney disease improving global outcomes (KDIGO) criteria, respectively...
March 26, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29582254/2-4-dinitrophenol-attenuates-mitochondrial-dysfunction-and-improves-neurobehavioral-outcomes-postanoxia-in-neonatal-rats
#19
Puneet K Samaiya, Gopeshwar Narayan, Ashok Kumar, Sairam Krishnamurthy
Following anoxia, a rapid and marked mitochondrial-linked cell death occurs in the cerebral cortex of newborn rats which leads to insult advancement within a couple of days and causes lifelong neurobehavioral abnormalities. The present study investigated the role of 2,4 dinitrophenol (2,4 DNP) in three doses, i.e.,1, 2.5, and 5 mg/kg on anoxia-induced time-dependent mitochondrial dysfunction and associated neurobehavioral outcome using a well-established global model of anoxia. Briefly, rat pups of 30-h age (P2) were subjected to two episodes of anoxia (10 min each) at 24 h of the time interval in an enclosed chamber supplied with 100% N2 and immersed in a water bath (35-37 °C) to avoid hypothermia...
March 26, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29571045/the-benefits-and-pitfalls-of-post-mortem-computed-tomography-in-forensic-external-examination-a-retrospective-study-of-145-cases
#20
Thibault Willaume, Audrey Farrugia, Estelle-Marie Kieffer, Jeanne Charton, Annie Geraut, Laurent Berthelon, Guillaume Bierry, Jean-Sébastien Raul
OBJECTIVE: Nowadays, post-mortem computed tomography (PMCT) has become an integral part of Forensic practice. The purpose of the study was to determine PMCT impact on diagnosis of the cause of death within the context of the external examination of the body, when autopsy has, at first, not been requested. MATERIAL AND METHODS: We reviewed the records of 145 cases for which unenhanced PMCT was performed in addition to the external examination of the body from January 2014 to July 2015 at the Institute of Forensic medicine in Strasbourg (France)...
March 7, 2018: Forensic Science International
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