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https://www.readbyqxmd.com/read/29895269/identity-challenges-and-burden-of-normality-after-dbs-for-severe-ocd-a-narrative-case-study
#1
Peter Bosanac, Bridget Elizabeth Hamilton, James Lucak, David Castle
BACKGROUND: Deep Brain Stimulation (DBS) is an emerging and potentially powerful biological treatment for severe Obsessive-Compulsive Disorder (OCD), but the wider impact of the intervention and the sometimes dramatic reduction in symptoms need greater attention in research and practice. The aim of this case study is to explore the subjective experience of preparing for and undergoing DBS as a treatment for severe and treatment-refractory OCD and the experience of the impact of the treatment...
June 13, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29872110/cervical-spinal-cord-compression-in-infants-with-achondroplasia-should-neuroimaging-be-routine
#2
Victoria R Sanders, Stephen H Sheldon, Joel Charrow
PURPOSE: To examine results of magnetic resonance imaging (MRI), polysomnograms (PSG), and patient outcomes in patients with achondroplasia in light of recent screening recommendations for infants with achondroplasia. METHODS: We reviewed medical records of 49 patients with achondroplasia followed at our institution between September 1997 and January 2017, including physical exams, MRIs, PSGs (when available), and surgical histories. Appropriate PSG data were available for 39 of these patients...
June 5, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29798687/thrombotic-storm-in-a-4-year-old-boy-with-a-thrombus-in-the-right-atrium
#3
Jing-Yao Ma, Xin Zhang, Xiao-Feng Li, Le-Jian He, Ning Ma, Yun-Yun Wei, Run-Hui Wu, Fang-Yun Wang
Thrombotic storm (TS) is a rare disease, especially with thrombus in the heart of pediatric patient. We present a case of a 4-year-old boy, who was diagnosed with TS during his first hospitalization due to lower extremity deep venous thrombosis, pulmonary embolism, and thrombosis of the inferior vena cava, cerebral, left internal jugular, portal, renal, and iliac veins. He was eventually prescribed with rivaroxaban to control thrombosis after 30 days of successive use of low-molecular-weight heparin, unfractionated heparin, and warfarin, which were demonstrating little effect on preventing thrombosis, and the patient was intolerant to argatroban...
January 2018: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29785456/methylene-blue-fluorescence-of-the-ureter-during-colorectal-surgery
#4
Thomas G Barnes, Roel Hompes, Jacqueline Birks, Neil J Mortensen, Oliver Jones, Ian Lindsey, Richard Guy, Bruce George, Chris Cunningham, Trevor M Yeung
BACKGROUND: Iatrogenic ureteric injury is a serious complication of colorectal surgery. Incidence is estimated to be between 0.3 and 1.5%. Of all ureteric injuries, 9% occur during colorectal procedures. Ureteric stents are utilised as a method to reduce the risk of injury; however, these are not without risk and do not guarantee prevention of injury. Fluorescence is a safe and effective alternative for intraoperative ureteric localisation. This proof of principle study aims to assess the use of methylene blue to fluoresce the ureter during colorectal surgery...
May 21, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29725670/crucial-breakthrough-of-second-near-infrared-biological-window-fluorophores-design-and-synthesis-toward-multimodal-imaging-and-theranostics
#5
Shuqing He, Jun Song, Junle Qu, Zhen Cheng
The development of fluorophores and molecular probes for the second near-infrared biological window (NIR-II, 1000-1700 nm) represents an important, newly emerging and dynamic field in molecular imaging, chemical biology and materials chemistry. Because of reduced scattering, minimal absorption and negligible autofluorescence, NIR-II imaging provides high resolution, a high signal-to-noise ratio, and deep tissue penetration capability. Among various state-of-the-art bioimaging modalities, one of the greatest challenges in developing novel probes is to achieve both high resolution and sensitivity...
May 4, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29700599/pilot-study-on-probe-based-confocal-laser-endomicroscopy-for-colorectal-neoplasms-an-initial-experience-in-japan
#6
Seiichiro Abe, Yutaka Saito, Yasuhiro Oono, Yusaku Tanaka, Taku Sakamoto, Masayoshi Yamada, Takeshi Nakajima, Takahisa Matsuda, Hiroaki Ikematsu, Tomonori Yano, Shigeki Sekine, Motohiro Kojima, Hidetsugu Yamagishi, Hiroyuki Kato
BACKGROUND: The aim of this pilot study is to investigate the diagnostic yield of probe-based confocal laser endomicroscopy (pCLE) in the evaluation of depth of invasion in colorectal lesions. METHODS: Patients with colorectal lesions eligible for either endoscopic treatment or surgery were enrolled in the study. Tumor's depth of invasion was classified as mucosal or slight submucosal (M-SM1) and deep submucosal invasion or deeper (SM2 or deeper). White light endoscopy (WLE), magnifying narrow band imaging (M-NBI), and magnifying chromoendoscopy (M-CE) were used to assess colorectal lesions, and pCLE was used to identify tumor's features related to SM2 or deeper...
April 26, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29691335/novel-insights-into-staphylococcus-aureus-deep-bone-infections-the-involvement-of-osteocytes
#7
Dongqing Yang, Asiri R Wijenayaka, Lucian B Solomon, Stephen M Pederson, David M Findlay, Stephen P Kidd, Gerald J Atkins
Periprosthetic joint infection (PJI) is a potentially devastating complication of orthopedic joint replacement surgery. PJI with associated osteomyelitis is particularly problematic and difficult to cure. Whether viable osteocytes, the predominant cell type in mineralized bone tissue, have a role in these infections is not clear, although their involvement might contribute to the difficulty in detecting and clearing PJI. Here, using Staphylococcus aureus , the most common pathogen in PJI, we demonstrate intracellular infection of human-osteocyte-like cells in vitro and S...
April 24, 2018: MBio
https://www.readbyqxmd.com/read/29581022/neuro-endoscopic-cylinder-surgery-and-5-aminolevulinic-acid-5-ala-photodynamic-diagnosis-of-deep-seated-intracranial-lesions
#8
Jungsu Choo, Kazuhito Takeuchi, Yuichi Nagata, Fumiharu Ohka, Yugo Kishida, Tadashi Watanabe, Yusuke Satoh, Tetsuya Nagatani, Kyozo Kato, Toshihiko Wakabayashi, Atsushi Natsume
BACKGROUND: Microscopic detection of intracranial brain tumors with 5-aminolevulinic acid (5-ALA) has proven extremely useful, and reports the use of 5-ALA have recently increased. However, few reports have described 5-ALA photodynamic diagnosis (PDD) using a neuro-endoscope. We performed neuro-endoscopic 5-ALA PDD for various brain lesions and present a procedure using only a neuro-endoscope. METHODS: We describe the diagnosis of 20 intracranial brain lesion cases with a 5-ALA-guided fluorescence endoscope...
March 23, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29501118/interdisciplinary-treatment-for-a-compensated-class-ii-partially-edentulous-malocclusion-orthodontic-creation-of-a-posterior-implant-site
#9
Grace Chiu, Chris Chang, W Eugene Roberts
A 36-year-old woman with good periodontal health sought treatment for a compensated Class II partially edentulous malocclusion associated with a steep mandibular plane (SN-MP, 45°), 9 missing teeth, a 3-mm midline discrepancy, and compromised posterior occlusal function. She had multiple carious lesions, a failing fixed prostheses in the mandibular right quadrant replacing the right first molar, and a severely atrophic edentulous ridge in the area around the mandibular left first and second molars. After restoration of the caries, the mandibular left third molar served as anchorage to correct the mandibular arch crowding...
March 2018: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/29484862/-scarpa-fascia-and-abdominal-wall-deep-adipose-compartment-preservation-in-abdominoplasty-current-clinical-and-anatomical-review
#10
REVIEW
Lior Har-Shai, Yehiel Hayun, Eric Barel, Dean D Ad-El
During the last two decades, in parallel to the increased prevalence of bariatric procedures, there has been a marked increase in the prevalence of abdominoplasty surgery in the United States, and in accordance an increase in the scientific and clinical research related to all aspects of this technique. The most common complication of abdominoplasty is the formation of post-operative seroma. Various theories have been raised regarding the pathophysiology of seroma formation, and numerous methods for seroma prevention have been employed and tested...
February 2018: Harefuah
https://www.readbyqxmd.com/read/29484267/pocd-in-patients-receiving-total-knee-replacement-under-deep-vs-light-anesthesia-a-randomized-controlled-trial
#11
Ruixue Hou, Hong Wang, Lianhua Chen, Yimin Qiu, Shitong Li
Objectives: Clinical observation, as well as randomized controlled trials, indicated an increasing rate of postoperative cognitive dysfunction (POCD) with increasing depth of general anesthesia. However, the findings are subject to bias due to varying degree of analgesia. In this trial, we compared the rate of POCD between patients receiving light versus high anesthesia while holding analgesia comparable using nerve block. Methods: Elderly patients (≧60 years) receiving elective total knee replacement were randomized to receive the surgery under general anesthesia at BIS 40-50 (LOBIS group) or BIS 55-65 (HIBIS group)...
February 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29399612/validity-of-conventional-endoscopy-using-non-extension-sign-for-optical-diagnosis-of-colorectal-deep-submucosal-invasive-cancer
#12
Takashi Hisabe, Sumio Tsuda, Toshio Hoashi, Hiroshi Ishihara, Kazutomo Yamasaki, Tatsuhisa Yasaka, Fumihito Hirai, Toshiyuki Matsui, Kenshi Yao, Hiroshi Tanabe, Akinori Iwashita
Background and study aims:  The non-extension sign relates to a localized increase in thickness and rigidity due to deep submucosal invasive (SM-d: depth of 1000 μm or more) cancer. The present study aimed to evaluate the efficacy of the non-extension sign in assessing the optical diagnosis of colorectal SM-d cancer. Patients and methods:  We retrospectively analyzed 309 patients with 315 early colorectal cancers that had been endoscopically or surgically resected...
February 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29378941/in-vivo-wireless-photonic-photodynamic-therapy
#13
Akshaya Bansal, Fengyuan Yang, Tian Xi, Yong Zhang, John S Ho
An emerging class of targeted therapy relies on light as a spatially and temporally precise stimulus. Photodynamic therapy (PDT) is a clinical example in which optical illumination selectively activates light-sensitive drugs, termed photosensitizers, destroying malignant cells without the side effects associated with systemic treatments such as chemotherapy. Effective clinical application of PDT and other light-based therapies, however, is hindered by challenges in light delivery across biological tissue, which is optically opaque...
February 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29368069/effect-of-low-level-laser-therapy-on-the-healing-process-of-donor-site-in-patients-with-grade-3-burn-ulcer-after-skin-graft-surgery-a-randomized-clinical-trial
#14
Reza Vaghardoost, Mahnoush Momeni, Nooshafarin Kazemikhoo, Soheila Mokmeli, Mostafa Dahmardehei, Fereshteh Ansari, Mohammad Ali Nilforoushzadeh, Parisa Sabr Joo, Sara Mey Abadi, Soheila Naderi Gharagheshlagh, Saeed Sassani
Skin graft is a standard therapeutic technique in patients with deep ulcers, but managing donor site after grafting is very important. Although several modern dressings are available to enhance the comfort of donor site, using techniques that accelerate wound healing may enhance patient satisfaction. Low-level laser therapy (LLLT) has been used in several medical fields, including healing of diabetic, surgical, and pressure ulcers, but there is not any report of using this method for healing of donor site in burn patients...
January 24, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29303876/optical-coherence-tomography-angiography-description-of-ocular-decompression-retinopathy-after-deep-sclerectomy-in-traumatic-glaucoma
#15
Lauriane Salinas, Ankita Chaudhary, Kaweh Mansouri
PURPOSE: The purpose of this article is to present a case of ocular decompression retinopathy (ODR) occurring after uncomplicated deep sclerectomy with Mitomycin C using optical coherence tomography angiography (OCTA). PATIENT AND METHOD: This is a single case report. RESULTS: A 55-year-old man with traumatic glaucoma in the right eye complained of blurred vision. Visual acuity was 20/25 and intraocular pressure (IOP) was 50 mm Hg. Deep sclerectomy with Mitomycin C was performed...
March 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29298873/multicentre-prospective-evaluation-of-real-time-optical-diagnosis-of-t1-colorectal-cancer-in-large-non-pedunculated-colorectal-polyps-using-narrow-band-imaging-the-optical-study
#16
Yara Backes, Matthijs P Schwartz, Frank Ter Borg, Frank H J Wolfhagen, John N Groen, Wouter H de Vos Tot Nederveen Cappel, Jeroen van Bergeijk, Joost M J Geesing, Bernhard W M Spanier, Paul Didden, Frank P Vleggaar, Miangela M Lacle, Sjoerd G Elias, Leon M G Moons
OBJECTIVE: This study evaluated the preresection accuracy of optical diagnosis of T1 colorectal cancer (CRC) in large non-pedunculated colorectal polyps (LNPCPs). DESIGN: In this multicentre prospective study, endoscopists predicted the histology during colonoscopy in consecutive patients with LNPCPs using a standardised procedure for optical assessment. The presence of morphological features assessed with white light, and vascular and surface pattern with narrow-band imaging (NBI) were recorded, together with the optical diagnosis, the confidence level of prediction and the recommended treatment...
January 3, 2018: Gut
https://www.readbyqxmd.com/read/29158852/curative-metatarsal-bone-surgery-combined-with-intralesional-administration-of-recombinant-human-epidermal-growth-factor-in-diabetic-neuropathic-ulceration-of-the-forefoot-a-prospective-open-uncontrolled-nonrandomized-observational-study
#17
Aristides L Garcia Herrera, Ridel de Jesús Febles Sanabria, Liliana de Los Ángeles Acosta Cabadilla, Miriam Moliner Cartaya
Background: Curative surgery is performed for a foot with ulcers and loss of protective sensation to heal the wound and prevent amputation. Evidence supports that patients with diabetes have decreased concentrations of growth factors in their tissues, notably epidermal growth factor (EGF). Injecting EGF deep into the bottom of the wound and its contours encourages a more effective response in terms of granulation tissue growth and wound closure. Objective: To assess the effectiveness and safety of curative metatarsal bone surgery combined with intralesional administration of human recombitant EGF in neuropathic diabetic forefoot ulceration...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29141056/in-vivo-histological-analysis-of-a-fractional-co2-laser-system-intended-for-treatment-of-soft-tissue
#18
Elisabeth Hurliman, Brian Zelickson, Jeffrey Kenkel
<p>BACKGROUND: Fractional ablative lasers have been shown to be safe and effective for improving wrinkles, scars, skin texture, and dyspigmentation. However, the exact effects of this technology in vivo on epidermal and dermal skin constituents have not been delineated. This study evaluated the in vivo histological effects over time of treatment with a fractional ablative CO2 system, using different treatment parameters. MATERIALS AND METHODS: Healthy adult volunteers were enrolled in this multicenter clinical study...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29118500/iridoplasty-of-fixed-dilated-pupil-urrets-zavalia-syndrome-after-deep-anterior-lamellar-keratoplasty
#19
Efthalia Ntora, Nikolaos Ziakas
A 38-year-old woman with advanced keratoconus initially developed Urrets-Zavalia Syndrome (UZS) in the left eye after deep anterior lamellar keratoplasty. During the uneventful surgery, a 7-mm-wide pupil unresponsive to light was noticed. On the first postoperative day, intraocular pressure (IOP) was elevated up to 45 mmHg with shallow anterior chamber (AC). A peripheral iridotomy in 2 o'clock position was conducted and a fixed combination of brinzolamide 1% and timolol 0.5% was administered topically. In the subsequent postoperative period, IOP was successfully reduced, but the patient reported severe photophobia, glare, and decreased vision...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28899891/effect-of-anesthesia-de-pth-on-p-ostoperative-clinical-ou-t-come-in-patients-with-supratentorial-tumor-depth-study-protocol-for-a-randomized-controlled-trial
#20
Qianyu Cui, Yuming Peng, Xiaoyuan Liu, Bo Jia, Jia Dong, Ruquan Han
INTRODUCTION: Recent studies have shown that deep anaesthesia is associated with poor outcomes. However, no randomised controlled trials have been conducted to test the causality in patients undergoing brain tumour resection. METHODS AND ANALYSIS: DEPTH is a multicenter, randomised, parallel-group, blind trial. The depth of general anaesthesia will be monitored using the bispectral index (BIS). Patients elected for supratentorial tumour resection will be randomly allocated to the deep or the light anaesthesia group in which the target BIS value is 35 or 50, respectively...
September 11, 2017: BMJ Open
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